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PUBLICACIONES

 

 

spacerTrabajos Publicados por Isabel Varela Nieto
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  1. Domínguez-Ruiz, M.; Murillo-Cuesta, S.; Contreras, J.; Cantero, M.; Garrido, G.; Martín-Bernardo, B.; Gómez-Rosas, E.; Fernández, A.; Del Castillo, F.J.; Montoliu, L.; Varela-Nieto, I.; Del Castillo, I. "A murine model for the del(GJB6-D13S1830) deletion recapitulating the phenotype of human DFNB1 hearing impairment: generation and functional and histopathological study.". BMC Genomics. 25(1): 359. (2024). (PMID: 38605287).
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  2. Lassaletta, L.; Calvino, M.; Díaz, M.; Morales-Puebla, J.M.; Sánchez-Cuadrado, I.; Varela-Nieto, I.; Gavilán, J. "Intraoperative assessment of cochlear nerve functionality in various vestibular schwannoma scenarios: Lessons learned.". Hear Res. 446(): 108997. (2024). (PMID: 38564963).
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  3. Lassaletta, L.; Acle Cervera, L.; Altuna, X.; Amilibia Cabeza, E.; Arístegui Ruiz, M.; Batuecas Caletrio, Á.; Benítez Del Rosario, J.; Cabanillas Farpón, R.; Costales Marcos, M.; Escada, P.; Espinosa-Sánchez, J.M.; García Leal, R.; Gavilán, J.; Gómez Martínez, J.; González-Aguado, R.; Martinez-Glez, V.; Guerra Jiménez, G.; Harguindey Antolí-Candela, A.; Hernández García, B.J.; Orús Dotú, C.; Polo López, R.; Manrique, M.; Martín Sanz, E.; Martínez Álvarez, R.; Martínez, H.; Martínez-Martínez, M.; Rey-Martinez, J.; Ropero Romero, F.; Santa Cruz Ruiz, S.; Vallejo, L.Á.; Soto Varela, A.; Varela-Nieto, I.; Morales Puebla, J.M. "Clinical practice guideline on the management of vestibular schwannoma.". Acta Otorrinolaringol Esp (Engl Ed). (): . (2024). (PMID: 38346489).
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  4. de Lope, C.; García-Lucena, R.; Magariños, M.; León, Y.; Casa-Rodríguez, N.; Contreras, N.; Escudero-Iriarte, C.; Varela-Nieto, I.; Maire, P.; Palmero, I. "Dysfunction of programmed embryo senescence is linked to genetic developmental defects.". Development. (): . (2023). (PMID: 37017267).
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  5. García-Mato, Á.; Cervantes, B.; Rodríguez-de la Rosa, L.; Varela-Nieto, I. "IGF-1 Controls Metabolic Homeostasis and Survival in HEI-OC1 Auditory Cells through AKT and mTOR Signaling.". Antioxidants (Basel). 12(2): . (2023). (PMID: 36829792).
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  6. Alsina, B.; Heller, S.; Varela-Nieto, I. "Editorial: Inner ear biology: Development, physiopathology, repair and recovery.". Front Cell Dev Biol. 10(): 1049463. (2022). (PMID: 36313579).
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  7. Landegger, L.D.; Fujita, T.; Jan, T.A.; Varela-Nieto, I. "Editorial: Otologic Trauma, Pathology, and Therapy.". Front Cell Neurosci. 16(): 900074. (2022). (PMID: 35496907).
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  8. Palmero, I.; Gorgoulis, V.; Varela-Nieto, I. "Editorial: The Role of Cellular Senescence in Health and Disease.". Front Cell Neurosci. 16(): 882417. (2022). (PMID: 35431814).
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  9. García-Mato, Á.; Cervantes, B.; Murillo-Cuesta, S.; Rodríguez-de la Rosa, L.; Varela-Nieto, I. "Insulin-like Growth Factor 1 Signaling in Mammalian Hearing.". Genes (Basel). 12(10): . (2021). (PMID: 34680948).
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  10. Varela-Nieto, I.; Murillo-Cuesta, S.; Rodríguez-de la Rosa, L.; Oset-Gasque, M.J.; Marco-Contelles, J. "Use of Radical Oxygen Species Scavenger Nitrones to Treat Oxidative Stress-Mediated Hearing Loss: State of the Art and Challenges.". Front Cell Neurosci. 15(): 711269. (2021). (PMID: 34539349).
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  11. Bermúdez-Muñoz, J.M.; Celaya, A.M.; García-Mato, Á.; Muñoz-Espín, D.; Rodríguez-de la Rosa, L.; Serrano, M.; Varela-Nieto, I. "Dual-Specificity Phosphatase 1 (DUSP1) Has a Central Role in Redox Homeostasis and Inflammation in the Mouse Cochlea.". Antioxidants (Basel). 10(9): . (2021). (PMID: 34572983).
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  12. Celaya, A.M.; Rodríguez-de la Rosa, L.; Bermúdez-Muñoz, J.M.; Zubeldia, J.M.; Romá-Mateo, C.; Avendaño, C.; Pallardó, F.V.; Varela-Nieto, I. "IGF-1 Haploinsufficiency Causes Age-Related Chronic Cochlear Inflammation and Increases Noise-Induced Hearing Loss.". Cells. 10(7): . (2021). (PMID: 34359856).
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  13. León, Y.; Magariños, M.; Varela-Nieto, I. "Ceramide Kinase Inhibition Blocks IGF-1-Mediated Survival of Otic Neurosensory Progenitors by Impairing AKT Phosphorylation.". Front Cell Dev Biol. 9(): 678760. (2021). (PMID: 34179008).
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  14. Murillo-Cuesta, S.; Celaya, A.M.; Cervantes, B.; Bermúdez-Muñoz, J.M.; Rodríguez-de la Rosa, L.; Contreras, J.; Sánchez-Pérez, I.; Varela-Nieto, I. "Therapeutic efficiency of the APAF-1 antagonist LPT99 in a rat model of cisplatin-induced hearing loss.". Clin Transl Med. 11(4): e363. (2021). (PMID: 33931965).
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  15. Perin, P.; Marino, F.; Varela-Nieto, I.; Szczepek, A.J. "Editorial: Neuroimmunology of the Inner Ear.". Front Neurol. 12(): 635359. (2021). (PMID: 33633679).
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  16. Klionsky, D.J.; [ .., ].; Bartolome, A.; [ .., ].; Cuadrado, A.; [ .., ].; Escalante, R.; [ .., ].; García-Sanz, P.; [ .., ].; Lastres-Becker, I.; [ .., ].; León, Y.; [ .., ].; Martin-Sanz, P.; [ .., ].; Pajares, M.; [ .., ].; Rojo, A.I.; [ .., ].; Valverde, A.M.; [ .., ].; Varela-Nieto, I.; [ .., ].; Villalobo, A.; [ .., ].; Vincent, O.; [ .., ].; Tong, C.K. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).". Autophagy. (): 1-382. (2021). (PMID: 33634751).
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  17. Bermúdez-Muñoz, J.M.; Celaya, A.M.; Hijazo-Pechero, S.; Wang, J.; Serrano, M.; Varela-Nieto, I. "G6PD overexpression protects from oxidative stress and age-related hearing loss.". Aging Cell. (): e13275. (2020). (PMID: 33222382).
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  18. Murillo-Cuesta, S.; Artuch, R.; Asensio, F.; de la Villa, P.; Dierssen, M.; Enríquez, J.A.; Fillat, C.; Fourcade, S.; Ibáñez, B.; Montoliu, L.; Oliver, E.; Pujol, A.; Salido, E.; Vallejo, M.; Varela-Nieto, I. "The Value of Mouse Models of Rare Diseases: A Spanish Experience.". Front Genet. 11(): 583932. (2020). (PMID: 33173540).
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  19. Varela-Nieto, I.; Murillo-Cuesta, S.; Calvino, M.; Cediel, R.; Lassaletta, L. "Drug development for noise-induced hearing loss.". Expert Opin Drug Discov. (): 1-15. (2020). (PMID: 32838572).
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  20. Magariños, M.; Barajas-Azpeleta, R.; Varela-Nieto, I.; R Aburto, M. "Otic Neurogenesis Is Regulated by TGFβ in a Senescence-Independent Manner.". Frontiers in cellular neuroscience. 14(): 217. (2020). (PMID: 32973450).
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  21. Lassaletta, L.; Calvino, M.; Morales-Puebla, J.M.; Lapunzina, P.; Rodriguez-de la Rosa, L.; Varela-Nieto, I.; Martinez-Glez, V. "Biomarkers in Vestibular Schwannoma-Associated Hearing Loss.". Front Neurol. 10(): 978. (2019). (PMID: 31620068).
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  22. Cervantes, B.; Arana, L.; Murillo-Cuesta, S.; Bruno, M.; Alkorta, I.; Varela-Nieto, I. "Solid Lipid Nanoparticles Loaded with Glucocorticoids Protect Auditory Cells from Cisplatin-Induced Ototoxicity.". J Clin Med. 8(9): . (2019). (PMID: 31540035).
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  23. Partearroyo, T.; Murillo-Cuesta, S.; Vallecillo, N.; Bermúdez-Muñoz, J.M.; Rodríguez-de la Rosa, L.; Mandruzzato, G.; Celaya, A.M.; Zeisel, S.H.; Pajares, M.A.; Varela-Moreiras, G.; Varela-Nieto, I. "Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia.". FASEB J.. 33(5): 5942-5956. (2019). (PMID: 30753104).
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  24. Celaya, A.M.; Sánchez-Pérez, I.; Bermúdez-Muñoz, J.M.; Rodríguez-de la Rosa, L.; Pintado-Berninches, L.; Perona, R.; Murillo-Cuesta, S.; Varela-Nieto, I. "Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss.". Elife. 8(): . (2019). (PMID: 30938680).
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  25. Gibaja, A.; Aburto, M.R.; Pulido, S.; Collado, M.; Hurle, J.M.; Varela-Nieto, I.; Magariños, M. "TGFβ2-induced senescence during early inner ear development.". Scientific reports. 9(1): 5912. (2019). (PMID: 30976015).
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  26. Fuentes-Santamaría, V.; Alvarado, J.C.; Rodríguez-de la Rosa, L.; Juiz, J.M.; Varela-Nieto, I. "Neuroglial Involvement in Abnormal Glutamate Transport in the Cochlear Nuclei of the Igf1-/- Mouse.". Front Cell Neurosci. 13(): 67. (2019). (PMID: 30881288).
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  27. Varela-Nieto, I.; Palmero, I.; Magariños, M. "Complementary and distinct roles of autophagy, apoptosis and senescence during early inner ear development.". Hear. Res.. (): . (2019). (PMID: 30711386).
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  28. Varela-Nieto, I.; Chowen, J.A.; García-Segura, L.M. "Editorial: Hormones and Neural Aging: Lessons From Experimental Models.". Front Aging Neurosci. 10(): 374. (2018). (PMID: 30498442).
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  29. Schosserer, M.; Banks, G.; Dogan, S.; Dungel, P.; Fernandes, A.; Presen, D.M.; Matheu, A.; Osuchowski, M.; Potter, P.; Sanfeliu, C.; Tuna, B.G.; Varela-Nieto, I.; Bellantuono, I. "Modelling physical resilience in ageing mice.". Mech. Ageing Dev.. (): . (2018). (PMID: 30290161).
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  30. Cano, A.; Dargent, G.; Carriazo, A.; López-Samaniego, L.; Apostolo, J.; Campos, E.; Holland, C.; Varela-Nieto, I.; Luz Sánchez-Sánchez, M.; Illario, M.; Iaccarino, G.; Roller, R.E.; Goossens, E.; Vollenbroek-Hutten, M.; Pais, S.; Schena, F.; Musian, D.; Alvino, S.; Maggio, M.; Liotta, G.; Ussai, S.; Orfila, F.; O'Caoimh, R.; Paul, C.; Pazzi, S.; Romano, V.; Obbia, P. "Tackling frailty and functional decline: Background of the action group A3 of the European innovation partnership for active and healthy ageing.". Maturitas. 115(): 69-73. (2018). (PMID: 30049350).
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  31. Wesdorp, M.; Murillo-Cuesta, S.; Peters, T.; Celaya, A.M.; Oonk, A.; Schraders, M.; Oostrik, J.; Gomez-Rosas, E.; Beynon, A.J.; Hartel, B.P.; Okkersen, K.; Koenen, H.J.P.M.; Weeda, J.; Lelieveld, S.; Voermans, N.C.; Joosten, I.; Hoyng, C.B.; Lichtner, P.; Kunst, H.P.M.; Feenstra, I.; de Bruijn, S.E.; , .; Admiraal, R.J.C.; Yntema, H.G.; van Wijk, E.; Del Castillo, I.; Serra, P.; Varela-Nieto, I.; Pennings, R.J.E.; Kremer, H. "MPZL2, Encoding the Epithelial Junctional Protein Myelin Protein Zero-like 2, Is Essential for Hearing in Man and Mouse.". Am. J. Hum. Genet.. 103(1): 74-88. (2018). (PMID: 29961571).
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  32. Espino Guarch, M.; Font-Llitjós, M.; Murillo-Cuesta, S.; Errasti-Murugarren, E.; Celaya, A.M.; Girotto, G.; Vuckovic, D.; Mezzavilla, M.; Vilches, C.; Bodoy, S.; Sahún, I.; González, L.; Prat, E.; Zorzano, A.; Dierssen, M.; Varela-Nieto, I.; Gasparini, P.; Palacín, M.; Nunes, V. "Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss.". Elife. 7(): . (2018). (PMID: 29355479).
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  33. García-Alcántara, F.; Murillo-Cuesta, S.; Pulido, S.; Bermúdez-Muñoz, J.M.; Martínez-Vega, R.; Milo, M.; Varela-Nieto, I.; Rivera, T. "The expression of oxidative stress response genes is modulated by a combination of resveratrol and N-acetylcysteine to ameliorate ototoxicity in the rat cochlea.". Hear. Res.. 358(): 10-21. (2017). (PMID: 29304389).
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  34. Rodríguez-de la Rosa, L.; Lassaletta, L.; Calvino, M.; Murillo-Cuesta, S.; Varela-Nieto, I. "The Role of Insulin-Like Growth Factor 1 in the Progression of Age-Related Hearing Loss.". Front Aging Neurosci. 9(): 411. (2017). (PMID: 29311900).
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  35. Lassaletta, L.; Polak, M.; Huesers, J.; Díaz-Gómez, M.; Calvino, M.; Varela-Nieto, I.; Gavilán, J. "Usefulness of Electrical Auditory Brainstem Responses to Assess the Functionality of the Cochlear Nerve Using an Intracochlear Test Electrode.". Otol. Neurotol.. 38(10): e413-e420. (2017). (PMID: 29076926).
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  36. Magariños, M.; Pulido, S.; Aburto, M.R.; de Iriarte Rodríguez, R.; Varela-Nieto, I. "Autophagy in the Vertebrate Inner Ear.". Front Cell Dev Biol. 5(): 56. (2017). (PMID: 28603711).
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  37. Partearroyo, T.; Vallecillo, N.; Pajares, M.A.; Varela-Moreiras, G.; Varela-Nieto, I. "Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss.". Front Mol Neurosci. 10(): 107. (2017). (PMID: 28487633).
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  38. Murillo-Cuesta, S.; Vallecillo, N.; Cediel, R.; Celaya, A.M.; Lassaletta, L.; Varela-Nieto, I.; Contreras, J. "A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection.". J Vis Exp. (121): . (2017). (PMID: 28362376).
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  39. Klionsky, D.J.; [ .., ].; Bartolomé, A.; [ .., ].; Escalante, R.; [ .., ].; Magariños, M.; [ .., ].; Martín-Sanz, P.; [ .., ].; Sanchez-Prieto, R.; [ .., ].; Valverde, A.M.; [ .., ].; Varela-Nieto, I.; [ .., ].; Zughaier, S.M. "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).". Autophagy. 12(1): 1-222. (2016). (PMID: 26799652).
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  40. Arroba, A.I.; Rodríguez-de la Rosa, L.; Murillo-Cuesta, S.; Vaquero-Villanueva, L.; Hurlé, J.M.; Varela-Nieto, I.; Valverde, Á.M. "Autophagy resolves early retinal inflammation in Igf1-deficient mice.". Dis Model Mech. 9(9): 965-974. (2016). (PMID: 27483352).
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  41. Martínez-Vega, R.; Murillo-Cuesta, S.; Partearroyo, T.; Varela-Moreiras, G.; Varela-Nieto, I.; Pajares, M.A. "Long-Term Dietary Folate Deficiency Accelerates Progressive Hearing Loss on CBA/Ca Mice.". Front Aging Neurosci. 8(): 209. (2016). (PMID: 27630560).
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  42. von Zglinicki, T.; Nieto, I.V.; Brites, D.; Karagianni, N.; Ortolano, S.; Georgopoulos, S.; Cardoso, A.L.; Novella, S.; Lepperdinger, G.; Trendelenburg, A.U.; van Os, R. "Frailty in mouse ageing: A conceptual approach.". Mech. Ageing Dev.. (): . (2016). (PMID: 27443148).
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  43. Fuentes-Santamaría, V.; Alvarado, J.C.; Rodríguez-de la Rosa, L.; Murillo-Cuesta, S.; Contreras, J.; Juiz, J.M.; Varela-Nieto, I. "Erratum to: IGF-1 deficiency causes atrophic changes associated with upregulation of VGluT1 and downregulation of MEF2 transcription factors in the mouse cochlear nuclei.". Brain Struct Funct. 221(2): 1205. (2016). (PMID: 25416135).
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  44. Fuentes-Santamaría, V.; Alvarado, J.C.; Rodríguez-de la Rosa, L.; Murillo-Cuesta, S.; Contreras, J.; Juiz, J.M.; Varela-Nieto, I. "IGF-1 deficiency causes atrophic changes associated with upregulation of VGluT1 and downregulation of MEF2 transcription factors in the mouse cochlear nuclei.". Brain Struct Funct. 221(2): 709-734. (2016). (PMID: 25378055).
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  45. Buniello, A.; Ingham, N.J.; Lewis, M.A.; Huma, A.C.; Martinez-Vega, R.; Varela-Nieto, I.; Vizcay-Barrena, G.; Fleck, R.A.; Houston, O.; Bardhan, T.; Johnson, S.L.; White, J.K.; Yuan, H.; Marcotti, W.; Steel, K.P. "Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing.". EMBO Mol Med. 8(3): 191-207. (2016). (PMID: 26881968).
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  46. de Iriarte Rodríguez, R.; Pulido, S.; Rodríguez-de la Rosa, L.; Magariños, M.; Varela-Nieto, I. "Age-regulated function of autophagy in the mouse inner ear.". Hear. Res.. 330(Pt A): 39-50. (2015). (PMID: 26235979).
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  47. Martínez-Vega, R.; Partearroyo, T.; Vallecillo, N.; Varela-Moreiras, G.; Pajares, M.A.; Varela-Nieto, I. "Long-term omega-3 fatty acid supplementation prevents expression changes in cochlear homocysteine metabolism and ameliorates progressive hearing loss in C57BL/6J mice.". J. Nutr. Biochem.. 26(12): 1424-1433. (2015). (PMID: 26321228).
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  48. García-Díaz, B.; Riquelme, R.; Varela-Nieto, I.; Jiménez, A.J.; de Diego, I.; Gómez-Conde, A.I.; Matas-Rico, E.; Aguirre, J.Á.; Chun, J.; Pedraza, C.; Santín, L.J.; Fernández, O.; Rodríguez de Fonseca, F.; Estivill-Torrús, G. "Loss of lysophosphatidic acid receptor LPA1 alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex.". Brain Struct Funct. 220(6): 3701-3720. (2015). (PMID: 25226845).
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  49. de Iriarte Rodríguez, R.; Magariños, M.; Pfeiffer, V.; Rapp, U.R.; Varela-Nieto, I. "C-Raf deficiency leads to hearing loss and increased noise susceptibility.". Cell. Mol. Life Sci.. 72(20): 3983-3998. (2015). (PMID: 25975225).
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  50. Apostolo, J.; Holland, C.; O'Connell, M.D.; Feeney, J.; Tabares-Seisdedos, R.; Tadros, G.; Campos, E.; Santos, N.; Robertson, D.A.; Marcucci, M.; Varela-Nieto, I.; Crespo-Facorro, B.; Vieta, E.; Navarro-Pardo, E.; Selva-Vera, G.; Balanzá-Martínez, V.; Cano, A. "Mild cognitive decline. A position statement of the Cognitive Decline Group of the European Innovation Partnership for Active and Healthy Ageing (EIPAHA).". Maturitas. (): . (2015). (PMID: 26520249).
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  51. Bouillon, R.; Slordahl, S.; Nogueria, M.M.; Steinhausen, K.; Varela-Nieto, I.; Pacini, G.; Röllinghoff, M.; Syka, J. "Public investment in biomedical research in Europe.". Lancet. 386(10001): 1335. (2015). (PMID: 26460768).
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  52. Rodríguez-de la Rosa, L.; Sánchez-Calderón, H.; Contreras, J.; Murillo-Cuesta, S.; Falagan, S.; Avendaño, C.; Dopazo, J.; Varela-Nieto, I.; Milo, M. "Comparative gene expression study of the vestibular organ of the Igf1 deficient mouse using whole-transcript arrays.". Hear. Res.. (): . (2015). (PMID: 26341476).
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  53. Magariños, M.; Milo, M.; Varela-Nieto, I. "Editorial: Aging, neurogenesis and neuroinflammation in hearing loss and protection.". Front Aging Neurosci. 7(): 138. (2015). (PMID: 26236234).
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  54. Sanz, L.; Murillo-Cuesta, S.; Cobo, P.; Cediel, R.; Contreras, J.; Rivera, T.; Varela-Nieto, I.; Avendaño, C. "Corrigendum to: Swept-sine noise-induced damage as a hearing loss model for preclinical assays.". Front Aging Neurosci. 7(): 79. (2015). (PMID: 26029100).
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  55. Murillo-Cuesta, S.; Rodríguez-de la Rosa, L.; Contreras, J.; Celaya, A.M.; Camarero, G.; Rivera, T.; Varela-Nieto, I. "Corrigendum: Transforming growth factor β1 inhibition protects from noise-induced hearing loss.". Front Aging Neurosci. 7(): 72. (2015). (PMID: 26005416).
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  56. López, I.P.; Rodriguez-de la Rosa, L.; Pais, R.S.; Piñeiro-Hermida, S.; Torrens, R.; Contreras, J.; Varela-Nieto, I.; Pichel, J.G. "Differential organ phenotypes after postnatal Igf1r gene conditional deletion induced by tamoxifen in UBC-CreERT2; Igf1r (fl/fl) double transgenic mice.". Transgenic Res.. 24(2): 279-294. (2015). (PMID: 25238791).
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  57. Murillo-Cuesta, S.; Rodríguez-de la Rosa, L.; Contreras, J.; Celaya, A.M.; Camarero, G.; Rivera, T.; Varela-Nieto, I. "Transforming growth factor β1 inhibition protects from noise-induced hearing loss.". Front Aging Neurosci. 7(): 32. (2015). (PMID: 25852546).
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  58. Martínez-Vega, R.; Garrido, F.; Partearroyo, T.; Cediel, R.; Zeisel, S.H.; Martínez-Álvarez, C.; Varela-Moreiras, G.; Varela-Nieto, I.; Pajares, M.A. "Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism.". FASEB J.. 29(2): 418-432. (2015). (PMID: 25384423).
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  59. Sanz, L.; Murillo-Cuesta, S.; Cobo, P.; Cediel-Algovia, R.; Contreras, J.; Rivera, T.; Varela-Nieto, I.; Avendaño, C. "Swept-sine noise-induced damage as a hearing loss model for preclinical assays.". Front Aging Neurosci. 7(): 7. (2015). (PMID: 25762930).
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  60. Malgrange, B.; Varela-Nieto, I.; de Medina, P.; Paillasse, M.R. "Targeting cholesterol homeostasis to fight hearing loss: a new perspective.". Front Aging Neurosci. 7(): 3. (2015). (PMID: 25688206).
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  61. Rodríguez-de la Rosa, L.; López-Herradón, A.; Portal-Núñez, S.; Murillo-Cuesta, S.; Lozano, D.; Cediel, R.; Varela-Nieto, I.; Esbrit, P. "Treatment with N- and C-terminal peptides of parathyroid hormone-related protein partly compensate the skeletal abnormalities in IGF-I deficient mice.". PLoS ONE. 9(2): e87536. (2014). (PMID: 24503961).
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  62. Muñoz-Espín, D.; Cañamero, M.; Maraver, A.; Gómez-López, G.; Contreras, J.; Murillo-Cuesta, S.; Rodríguez-Baeza, A.; Varela-Nieto, I.; Ruberte, J.; Collado, M.; Serrano, M. "Programmed cell senescence during mammalian embryonic development.". Cell. 155(5): 1104-1118. (2013). (PMID: 24238962).
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  63. Varela-Nieto, I.; Murillo-Cuesta, S.; Rodríguez-de la Rosa, L.; Lassatetta, L.; Contreras, J. "IGF-I deficiency and hearing loss: molecular clues and clinical implications.". Pediatr Endocrinol Rev. 10(4): 460-472. (2013). (PMID: 23957197).
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  64. Magariños, M.; Contreras, J.; Aburto, M.R.; Varela-Nieto, I. "Early development of the vertebrate inner ear.". Anat Rec (Hoboken). 295(11): 1775-1790. (2012). (PMID: 23044927).
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  65. Aburto, M.R.; Sánchez-Calderón, H.; Hurlé, J.M.; Varela-Nieto, I.; Magariños, M. "Early otic development depends on autophagy for apoptotic cell clearance and neural differentiation.". Cell Death Dis. 3(): e394. (2012). (PMID: 23034329).
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  66. Aburto, M.R.; Hurlé, J.M.; Varela-Nieto, I.; Magariños, M. "Autophagy during vertebrate development.". Cells. 1(3): 428-448. (2012). (PMID: 24710484).
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  67. Rodriguez-de la Rosa, L.; Fernandez-Sanchez, L.; Germain, F.; Murillo-Cuesta, S.; Varela-Nieto, I.; de la Villa, P.; Cuenca, N. "Age-related functional and structural retinal modifications in the Igf1-/- null mouse.". Neurobiol. Dis.. 46(2): 476-485. (2012). (PMID: 22402333).
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  68. Rivera, T.; Sanz, L.; Camarero, G.; Varela-Nieto, I. "Drug delivery to the inner ear: strategies and their therapeutic implications for sensorineural hearing loss.". Curr Drug Deliv. 9(3): 231-242. (2012). (PMID: 22283653).
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  69. Murillo-Cuesta, S.; Camarero, G.; González-Rodríguez, A.; De La Rosa, L.R.; Burks, D.J.; Avendaño, C.; Valverde, A.M.; Varela-Nieto, I. "Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function.". Mol. Med.. 18(): 260-269. (2012). (PMID: 22160220).
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  70. Aburto, M.R.; Magariños, M.; Leon, Y.; Varela-Nieto, I.; Sanchez-Calderon, H. "AKT signaling mediates IGF-I survival actions on otic neural progenitors.". PLoS ONE. 7(1): e30790. (2012). (PMID: 22292041).
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  71. Murillo-Cuesta, S.; Rodríguez-de la Rosa, L.; Cediel, R.; Lassaletta, L.; Varela-Nieto, I. "The role of insulin-like growth factor-I in the physiopathology of hearing.". Front Mol Neurosci. 4(): 11. (2011). (PMID: 21845174).
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  72. Magariños, M.; Aburto, M.R.; Sánchez-Calderón, H.; Muñoz-Agudo, C.; Rapp, U.R.; Varela-Nieto, I. "RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development.". PLoS ONE. 5(12): e14435. (2010). (PMID: 21203386).
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  73. Riquelme, R.; Cediel, R.; Contreras, J.; la Rosa Lourdes, R.D.; Murillo-Cuesta, S.; Hernandez-Sanchez, C.; Zubeldia, J.M.; Cerdan, S.; Varela-Nieto, I. "A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice.". Front Neuroanat. 4(): 27. (2010). (PMID: 20661454).
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  74. Hovatta, O.; Stojkovic, M.; Nogueira, M.; Varela-Nieto, I. "European scientific, ethical, and legal issues on human stem cell research and regenerative medicine.". Stem Cells. 28(6): 1005-1007. (2010). (PMID: 20533567).
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  75. Murillo-Cuesta, S.; Contreras, J.; Cediel, R.; Varela-Nieto, I. "Comparison of different aminoglycoside antibiotic treatments to refine ototoxicity studies in adult mice.". Lab. Anim.. 44(2): 124-131. (2010). (PMID: 19858169).
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  76. Murillo-Cuesta, S.; Contreras, J.; Zurita, E.; Cediel, R.; Cantero, M.; Varela-Nieto, I.; Montoliu, L. "Melanin precursors prevent premature age-related and noise-induced hearing loss in albino mice.". Pigment Cell Melanoma Res. 23(1): 72-83. (2010). (PMID: 19843244).
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  77. Sanchez-Calderon, H.; Rodriguez-de la Rosa, L.; Milo, M.; Pichel, J.G.; Holley, M.; Varela-Nieto, I. "RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors.". PLoS ONE. 5(1): e8699. (2010). (PMID: 20111592).
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  78. Santin, L.J.; Bilbao, A.; Pedraza, C.; Matas-Rico, E.; López-Barroso, D.; Castilla-Ortega, E.; Sánchez-López, J.; Riquelme, R.; Varela-Nieto, I.; de la Villa, P.; Suardíaz, M.; Chun, J.; De Fonseca, F.R.; Estivill-Torrús, G. "Behavioral phenotype of maLPA1-null mice: increased anxiety-like behavior and spatial memory deficits.". Genes Brain Behav.. 8(8): 772-784. (2009). (PMID: 19689455).
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  79. Murillo-Cuesta, S.; García-Alcántara, F.; Vacas, E.; Sistiaga, J.A.; Camarero, G.; Varela-Nieto, I.; Rivera, T. "Direct drug application to the round window: a comparative study of ototoxicity in rats.". Otolaryngol Head Neck Surg. 141(5): 584-590. (2009). (PMID: 19861195).
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  80. Fernández-Medarde, A.; Barhoum, R.; Riquelme, R.; Porteros, A.; Núñez, A.; de Luis, A.; de Las Rivas, J.; de la Villa, P.; Varela-Nieto, I.; Santos, E. "RasGRF1 disruption causes retinal photoreception defects and associated transcriptomic alterations.". J. Neurochem.. 110(2): 641-652. (2009). (PMID: 19457086).
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  81. Bell, D.; Streit, A.; Gorospe, I.; Varela-Nieto, I.; Alsina, B.; Giraldez, F. "Spatial and temporal segregation of auditory and vestibular neurons in the otic placode.". Dev. Biol.. 322(1): 109-120. (2008). (PMID: 18674529).
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  82. Rodríguez-de la Rosa, L.; Contreras-Rodríguez, J.; Cediel-Algovia, R.; León, Y.; Sánchez-Calderón, H.; Murillo-Cuesta, S.; Riquelme-Galiana, R.; de Diego-Sastre, J.I.; Prim-Espada, M.P.; Varela-Nieto, I.; , . "[Neurotrophic action of insulin-like growth factor-I in the inner ear].". Rev Neurol. 45(4): 245-250. (2008). (PMID: 17668408).
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  83. Sanchez-Calderon, H.; Milo, M.; Leon, Y.; Varela-Nieto, I. "A network of growth and transcription factors controls neuronal differentation and survival in the developing ear.". Int. J. Dev. Biol.. 51(6-7): 557-570. (2007). (PMID: 17891717).
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  84. Varela-Nieto, I.; Hartl, M.; Gorospe, I.; León, Y. "Anti-apoptotic actions of insulin-like growth factors: lessons from development and implications in neoplastic cell transformation.". Curr. Pharm. Des.. 13(7): 687-703. (2007). (PMID: 17346184).
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  85. Conejero, L.; Higaki, Y.; Baeza, M.L.; Fernández, M.; Varela-Nieto, I.; Zubeldia, J.M. "Pollen-induced airway inflammation, hyper-responsiveness and apoptosis in a murine model of allergy.". Clin. Exp. Allergy. 37(3): 331-338. (2007). (PMID: 17359383).
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  86. Cediel, R.; Riquelme, R.; Contreras, J.; Díaz, A.; Varela-Nieto, I. "Sensorineural hearing loss in insulin-like growth factor I-null mice: a new model of human deafness.". Eur J Neurosci. 23(2): 587-590. (2006). (PMID: 16420467).
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  87. Diaz-Casares, A.; Leon, Y.; de la Rosa, E.J.; Varela-Nieto, I. "Regulation of vertebrate sensory organ development: a scenario for growth hormone and insulin-like growth factors action.". Adv. Exp. Med. Biol.. 567(): 221-242. (2005). (PMID: 16370141).
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  88. Jones, D.R.; Pañeda, C.; Villar, A.V.; Alonso, A.; Goñi, F.M.; Bütikofer, P.; Brodbeck, U.; Shepherd, P.R.; Varela-Nieto, I. "Phosphorylation of glycosyl-phosphatidylinositol by phosphatidylinositol 3-kinase changes its properties as a substrate for phospholipases.". FEBS Lett.. 579(1): 59-65. (2005). (PMID: 15620691).
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  89. Varela-Nieto, I.; Morales-Garcia, J.A.; Vigil, P.; Diaz-Casares, A.; Gorospe, I.; Sánchez-Galiano, S.; Cañon, S.; Camarero, G.; Contreras, J.; Cediel, R.; Leon, Y. "Trophic effects of insulin-like growth factor-I (IGF-I) in the inner ear.". Hear. Res.. 196(1-2): 19-25. (2004). (PMID: 15464297).
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  90. Marí, M.; Colell, A.; Morales, A.; Pañeda, C.; Varela-Nieto, I.; García-Ruiz, C.; Fernández-Checa, J.C. "Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis.". J. Clin. Invest.. 113(6): 895-904. (2004). (PMID: 15067322).
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  91. Alsina, B.; Giraldez, F.; Varela-Nieto, I. "Growth factors and early development of otic neurons: interactions between intrinsic and extrinsic signals.". Curr. Top. Dev. Biol.. 57(): 177-206. (2003). (PMID: 14674481).
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  92. Camarero, G.; Leon, Y.; Gorospe, I.; De Pablo, F.; Alsina, B.; Giraldez, F.; Varela-Nieto, I. "Insulin-like growth factor 1 is required for survival of transit-amplifying neuroblasts and differentiation of otic neurons.". Dev. Biol.. 262(2): 242-253. (2003). (PMID: 14550788).
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  93. Varela-Nieto, I.; de la Rosa, E.J.; Valenciano, A.I.; León, Y. "Cell death in the nervous system: lessons from insulin and insulin-like growth factors.". Mol. Neurobiol.. 28(1): 23-50. (2003). (PMID: 14514984).
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  94. Frago, L.M.; Cañón, S.; de la Rosa, E.J.; León, Y.; Varela-Nieto, I. "Programmed cell death in the developing inner ear is balanced by nerve growth factor and insulin-like growth factor I.". J. Cell. Sci.. 116(Pt 3): 475-486. (2003). (PMID: 12508109).
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  95. Balboa, M.A.; Varela-Nieto, I.; Killermann Lucas, K.; Dennis, E.A. "Expression and function of phospholipase A(2) in brain.". FEBS Lett.. 531(1): 12-17. (2002). (PMID: 12401195).
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  96. Camarero, G.; Villar, M.A.; Contreras, J.; Fernández-Moreno, C.; Pichel, J.G.; Avendaño, C.; Varela-Nieto, I. "Cochlear abnormalities in insulin-like growth factor-1 mouse mutants.". Hear. Res.. 170(1-2): 2-11. (2002). (PMID: 12208536).
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  97. Pañeda, C.; Gorospe, I.; Herrera, B.; Nakamura, T.; Fabregat, I.; Varela-Nieto, I. "Liver cell proliferation requires methionine adenosyltransferase 2A mRNA up-regulation.". Hepatology. 35(6): 1381-1391. (2002). (PMID: 12029623).
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  98. Colombaioni, L.; Frago, L.M.; Varela-Nieto, I.; Pesi, R.; Garcia-Gil, M. "Serum deprivation increases ceramide levels and induces apoptosis in undifferentiated HN9.10e cells.". Neurochem. Int.. 40(4): 327-336. (2002). (PMID: 11792463).
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  99. Camarero, G.; Avendano, C.; Fernandez-Moreno, C.; Villar, A.; Contreras, J.; de Pablo, F.; Pichel, J.G.; Varela-Nieto, I. "Delayed inner ear maturation and neuronal loss in postnatal Igf-1-deficient mice.". J. Neurosci.. 21(19): 7630-7641. (2001). (PMID: 11567053).
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  100. Pañeda, C.; Villar, A.V.; Alonso, A.; Goñi, F.M.; Varela, F.; Brodbeck, U.; León, Y.; Varela-Nieto, I.; Jones, D.R. "Purification and characterization of insulin-mimetic inositol phosphoglycan-like molecules from grass pea (Lathyrus sativus) seeds.". Mol. Med.. 7(7): 454-460. (2001). (PMID: 11683370).
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  101. Frago, L.M.; Pañeda, C.; Fabregat, I.; Varela-Nieto, I. "Short-chain ceramide regulates hepatic methionine adenosyltransferase expression.". J. Hepatol.. 34(2): 192-201. (2001). (PMID: 11281546).
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  102. Pimentel, B.; Sanz, C.; Varela-Nieto, I.; Rapp, U.R.; De Pablo, F.; de La Rosa, E.J. "c-Raf regulates cell survival and retinal ganglion cell morphogenesis during neurogenesis.". J. Neurosci.. 20(9): 3254-3262. (2000). (PMID: 10777790).
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  103. Frago, L.M.; Camerero, G.; Cañón, S.; Pañeda, C.; Sanz, C.; Leon, Y.; Giraldez, F.; Varela-Nieto, I. "Role of diffusible and transcription factors in inner ear development: implications in regeneration.". Histol. Histopathol.. 15(2): 657-666. (2000). (PMID: 10809387).
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  104. Sanz, C.; León, Y.; Cañón, S.; Alvarez, L.; Giraldez, F.; Varela-Nieto, I. "Pattern of expression of the jun family of transcription factors during the early development of the inner ear: implications in apoptosis.". J. Cell. Sci.. 112 ( Pt 22)(): 3967-3974. (1999). (PMID: 10547357).
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  105. Jones, D.R.; Varela-Nieto, I. "Diabetes and the role of inositol-containing lipids in insulin signaling.". Mol. Med.. 5(8): 505-514. (1999). (PMID: 10501653).
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  106. Villar, A.V.; Alonso, A.; Pañeda, C.; Varela-Nieto, I.; Brodbeck, U.; Goñi, F.M. "Towards the in vitro reconstitution of caveolae. Asymmetric incorporation of glycosylphosphatidylinositol (GPI) and gangliosides into liposomal membranes.". FEBS Lett.. 457(1): 71-74. (1999). (PMID: 10486566).
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  107. Varela-Nieto, I.; Silos-Santiago, I. "Introduction to structural and functional studies on nerve growth factor.". Microsc. Res. Tech.. 45(4-5): 206. (1999). (PMID: 10383111).
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  108. León, Y.; Sanz, C.; Frago, L.M.; Camarero, G.; Cañón, S.; Varela-Nieto, I.; Giráldez, F. "Involvement of insulin-like growth factor-I in inner ear organogenesis and regeneration.". Horm. Metab. Res.. 31(2-3): 126-132. (1999). (PMID: 10226792).
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  109. Sanz, C.; León, Y.; Troppmair, J.; Rapp, U.R.; Varela-Nieto, I. "Strict regulation of c-Raf kinase levels is required for early organogenesis of the vertebrate inner ear.". Oncogene. 18(2): 429-437. (1999). (PMID: 9927199).
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  110. Petitfrere, E.; Sartelet, H.; Vivien, D.; Varela-Nieto, I.; Elbtaouri, H.; Martiny, L.; Haye, B. "Glycosyl phosphatidylinositol (GPI)/inositolphosphate glycan (IPG): an intracellular signalling system involved in the control of thyroid cell proliferation.". Biochimie. 80(12): 1063-1067. (1998). (PMID: 9924986).
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  111. León, Y.; Sanz, C.; Giráldez, F.; Varela-Nieto, I. "Induction of cell growth by insulin and insulin-like growth factor-I is associated with Jun expression in the otic vesicle.". J. Comp. Neurol.. 398(3): 323-332. (1998). (PMID: 9714146).
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  112. Villar, A.V.; Goñi, F.M.; Alonso, A.; Jones, D.R.; León, Y.; Varela-Nieto, I. "Phospholipase cleavage of glycosylphosphatidylinositol reconstituted in liposomal membranes.". FEBS Lett.. 432(3): 150-154. (1998). (PMID: 9720914).
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  113. Frago, L.M.; Giménez, A.; Rodriguez, E.N.; Varela-Nieto, I. "Pattern of methionine adenosyltransferase isoenzyme expression during rat liver regeneration after partial hepatectomy.". FEBS Lett.. 426(3): 305-308. (1998). (PMID: 9600256).
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  114. Frago, L.M.; León, Y.; de la Rosa, E.J.; Gómez-Muñoz, A.; Varela-Nieto, I. "Nerve growth factor and ceramides modulate cell death in the early developing inner ear.". J. Cell. Sci.. 111 ( Pt 5)(): 549-556. (1998). (PMID: 9454729).
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  115. Jones, D.R.; Varela-Nieto, I. "The role of glycosyl-phosphatidylinositol in signal transduction.". Int. J. Biochem. Cell Biol.. 30(3): 313-326. (1998). (PMID: 9611774).
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  116. Caro, H.N.; Kunjara, S.; Rademacher, T.W.; León, Y.; Jones, D.R.; Avila, M.A.; Varela-Nieto, I. "Isolation and partial characterisation of insulin-mimetic inositol phosphoglycans from human liver.". Biochem. Mol. Med.. 61(2): 214-228. (1997). (PMID: 9259987).
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  117. Gomez-Muñoz, A.; Frago, L.M.; Alvarez, L.; Varela-Nieto, I. "Stimulation of DNA synthesis by natural ceramide 1-phosphate.". Biochem. J.. 325 ( Pt 2)(): 435-440. (1997). (PMID: 9230125).
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  118. Jones, D.R.; Avila, M.A.; Sanz, C.; Varela-Nieto, I. "Glycosyl-phosphatidylinositol-phospholipase type D: a possible candidate for the generation of second messengers.". Biochem. Biophys. Res. Commun.. 233(2): 432-437. (1997). (PMID: 9144552).
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  119. Sanchez-Bueno, A.; Greenwood, M.R.; Varela-Nieto, I.; Marrero, I.; Gil, B.; Mato, J.M.; Cobbold, P.H. "Inositol-phosphoglycan inhibits calcium oscillations in hepatocytes by reducing calcium entry.". Cell Calcium. 21(2): 125-133. (1997). (PMID: 9132295).
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  120. Leon, Y.; Varela-Nieto, I.; Breen, K.C. "Neural cell adhesion molecule expression in the developing chick otic vesicle.". Biochem. Soc. Trans.. 25(1): 10S. (1997). (PMID: 9056908).
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  121. Sanz, C.; Leon, Y.; Garcia-Gil, M.; Varela-Nieto, I. "Role of Raf kinases during inner ear development.". Int. J. Dev. Biol.. Suppl 1(): 83S-84S. (1996). (PMID: 9087707).
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  122. Varela-Nieto, I.; León, Y.; Caro, H.N. "Cell signalling by inositol phosphoglycans from different species.". Comp. Biochem. Physiol. B, Biochem. Mol. Biol.. 115(2): 223-241. (1996). (PMID: 8939003).
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  123. León, Y.; Vazquez, E.; Sanz, C.; Vega, J.A.; Mato, J.M.; Giraldez, F.; Represa, J.; Varela-Nieto, I. "Insulin-like growth factor-I regulates cell proliferation in the developing inner ear, activating glycosyl-phosphatidylinositol hydrolysis and Fos expression.". Endocrinology. 136(8): 3494-3503. (1995). (PMID: 7628386).
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  124. Leon, Y.; Sanz, C.; Varela-Nieto, I. "Intracellular mediators of insulin-like growth factor I during otic vesicle development.". Biochem. Soc. Trans.. 23(2): 185S. (1995). (PMID: 7672208).
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  125. Clemente, R.; Jones, D.R.; Ochoa, P.; Romero, G.; Mato, J.M.; Varela-Nieto, I. "Role of glycosyl-phosphatidylinositol hydrolysis as a mitogenic signal for epidermal growth factor.". Cell. Signal.. 7(4): 411-421. (1995). (PMID: 8527310).
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  126. Jones, D.R.; Clemente, R.; Varela-Nieto, I. "Signalling at the epidermal growth factor receptor: role of glycosylphosphatidylinositol hydrolysis.". Biochem. Soc. Trans.. 23(2): 174S. (1995). (PMID: 7672200).
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  127. Zapata, A.; León, Y.; Mato, J.M.; Varela-Nieto, I.; Penadés, S.; Martín-Lomas, M. "Synthesis and investigation of the possible insulin-like activity of 1D-4-O- and 1D-6-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-myo-inositol 1-phosphate and 1D-6-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-myo-inositol 1,2-(cyclic phosphate).". Carbohydr. Res.. 264(1): 21-31. (1994). (PMID: 8001018).
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  128. Avila, M.A.; Clemente, R.; Varela-Nieto, I. "Mannosamine is an unspecific inhibitor of glycosyl-phosphatidylinositol biosynthesis in T-lymphocytes.". Biochem. Soc. Trans.. 22(1): 11S. (1994). (PMID: 8206201).
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  129. Represa, J.; Avila, M.A.; Romero, G.; Mato, J.M.; Giraldez, F.; Varela-Nieto, I. "Brain-derived neurotrophic factor and neurotrophin-3 induce cell proliferation in the cochleovestibular ganglion through a glycosyl-phosphatidylinositol signaling system.". Dev. Biol.. 159(1): 257-265. (1993). (PMID: 8365564).
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  130. Avila, M.A.; Varela-Nieto, I.; Romero, G.; Mato, J.M.; Giraldez, F.; Van De Water, T.R.; Represa, J. "Brain-derived neurotrophic factor and neurotrophin-3 support the survival and neuritogenesis response of developing cochleovestibular ganglion neurons.". Dev. Biol.. 159(1): 266-275. (1993). (PMID: 8365565).
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  131. Vasta, V.; Bruni, P.; Clemente, R.; Vannini, F.; Ochoa, P.; Romero, G.; Farnararo, M.; Varela-Nieto, I. "Role of the glycosylphosphatidylinositol/inositol phosphoglycan system in human fibroblast proliferation.". Exp. Cell Res.. 200(2): 439-443. (1992). (PMID: 1374038).
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  132. Avila, M.A.; Clemente, R.; Varela-Nieto, I. "A phosphatidylinositol-linkage-deficient T-cell mutant contains insulin-sensitive glycosyl-phosphatidylinositol.". Biochem. J.. 282 ( Pt 3)(): 681-686. (1992). (PMID: 1532490).
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  133. Bruni, P.; Vasta, V.; Berti, L.; Avila, M.A.; Farnararo, M.; Varela-Nieto, I. "An inositol phosphoglycan stimulates glycolysis in human platelets.". Biochem. Biophys. Res. Commun.. 180(2): 1041-1047. (1991). (PMID: 1835382).
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  134. Represa, J.; Avila, M.A.; Miner, C.; Giraldez, F.; Romero, G.; Clemente, R.; Mato, J.M.; Varela-Nieto, I. "Glycosyl-phosphatidylinositol/inositol phosphoglycan: a signaling system for the low-affinity nerve growth factor receptor.". Proc. Natl. Acad. Sci. U.S.A.. 88(18): 8016-8019. (1991). (PMID: 1654553).
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  135. Alvarez, L.; Avila, M.A.; Mato, J.M.; Castaño, J.G.; Varela-Nieto, I. "Insulin-like effects of inositol phosphate-glycan on messenger RNA expression in rat hepatocytes.". Mol. Endocrinol.. 5(8): 1062-1068. (1991). (PMID: 1719385).
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  136. Varela-Nieto, I.; Represa, J.; Avila, M.A.; Miner, C.; Mato, J.M.; Giraldez, F. "Inositol phospho-oligosaccharide stimulates cell proliferation in the early developing inner ear.". Dev. Biol.. 143(2): 432-435. (1991). (PMID: 1991566).
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  137. Villalba, M.; Varela, I.; Mérida, I.; Pajares, M.A.; Martínez del Pozo, A.; Mato, J.M. "Modulation by the ratio S-adenosylmethionine/S-adenosylhomocysteine of cyclic AMP-dependent phosphorylation of the 50 kDa protein of rat liver phospholipid methyltransferase.". Biochim. Biophys. Acta. 847(3): 273-279. (1985). (PMID: 2998482).
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  138. Pajares, M.A.; Alemany, S.; Varela, I.; Marin Cao, D.; Mato, J.M. "Purification and photoaffinity labelling of lipid methyltransferase from rat liver.". Biochem. J.. 223(1): 61-66. (1984). (PMID: 6497846).
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  139. Varela, I.; Mérida, I.; Pajares, M.; Villalba, M.; Mato, J.M. "Activation of partially purified rat liver lipid methyltransferase by phosphorylation.". Biochem. Biophys. Res. Commun.. 122(3): 1065-1070. (1984). (PMID: 6332623).
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  140. Mato, J.M.; Alvarez Chiva, V.; Marín Cao, D.; Varela, I.; García Gil, M.; Alemany, S. "[Hormonal regulation of the synthesis of phosphatidylcholine by transmethylation].". Rev Clin Esp. 171(1): 7-10. (1983). (PMID: 6658087).
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  141. Alemany, S.; Varela, I.; Mato, J.M. "Inhibition of phosphatidylcholine synthesis by vasopressin and angiotensin in rat hepatocytes.". Biochem. J.. 208(2): 453-457. (1982). (PMID: 6818955).
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  142. Alemany, S.; Varela, I.; Harper, J.F.; Mato, J.M. "Calmodulin regulation of phospholipid and fatty acid methylation by rat liver microsomes.". J. Biol. Chem.. 257(16): 9249-9251. (1982). (PMID: 6809733).
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  143. Alemany, S.; Varela, I.; Mato, J.M. "Stimulation by vasopressin and angiotensin of phospholipid methyltransferase in isolated rat hepatocytes.". FEBS Lett.. 135(1): 111-114. (1981). (PMID: 6797839).
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