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PUBLICACIONES

 

 

spacerTrabajos Publicados por Antonio Cuadrado Pastor
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  1. Morgenstern, C.; Lastres-Becker, I.; Demirdöğen, B.C.; Costa, V.M.; Daiber, A.; Foresti, R.; Motterlini, R.; Kalyoncu, S.; Arioz, B.I.; Genc, S.; Jakubowska, M.; Trougakos, I.P.; Piechota-Polanczyk, A.; Mickael, M.; Santos, M.; Kensler, T.W.; Cuadrado, A.; Copple, I.M. "Biomarkers of NRF2 signalling: Current status and future challenges.". Redox Biol. 72(): 103134. (2024). (PMID: 38643749).
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  2. Patibandla, C.; van Aalten, L.; Dinkova-Kostova, A.T.; Honda, T.; Cuadrado, A.; Fernández-Ginés, R.; McNeilly, A.D.; Hayes, J.D.; Cantley, J.; Sutherland, C. "Inhibition of glycogen synthase kinase-3 enhances NRF2 protein stability, nuclear localisation and target gene transcription in pancreatic beta cells.". Redox Biol. 71(): 103117. (2024). (PMID: 38479223).
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  3. Fernández-Ginés, R.; Encinar, J.A.; Escoll, M.; Carnicero-Senabre, D.; Jiménez-Villegas, J.; García-Yagüe, Á.J.; González-Rodríguez, Á.; Garcia-Martinez, I.; M Valverde, Á.; Rojo, A.I.; Cuadrado, A. "Specific targeting of the NRF2/β-TrCP axis promotes beneficial effects in NASH.". Redox Biol. 69(): 103027. (2024). (PMID: 38184999).
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  4. Bourdakou, M.M.; Fernández-Ginés, R.; Cuadrado, A.; Spyrou, G.M. "Drug repurposing on Alzheimer's disease through modulation of NRF2 neighborhood.". Redox Biol. 67(): 102881. (2023). (PMID: 37696195).
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  5. Palomino-Antolín, A.; Decouty-Pérez, C.; Farré-Alins, V.; Narros-Fernández, P.; Lopez-Rodriguez, A.B.; Álvarez-Rubal, M.; Valencia, I.; López-Muñoz, F.; Ramos, E.; Cuadrado, A.; Casas, A.I.; Romero, A.; Egea, J. "Redox Regulation of Microglial Inflammatory Response: Fine Control of NLRP3 Inflammasome through Nrf2 and NOX4.". Antioxidants (Basel). 12(9): . (2023). (PMID: 37760032).
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  6. García-Yagüe, Á.J.; Cuadrado, A. "Mechanisms of NURR1 Regulation: Consequences for Its Biological Activity and Involvement in Pathology.". Int J Mol Sci. 24(15): . (2023). (PMID: 37569656).
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  7. Bourgonje, A.R.; Kloska, D.; Grochot-Przęczek, A.; Feelisch, M.; Cuadrado, A.; van Goor, H. "Personalized redox medicine in inflammatory bowel diseases: an emerging role for HIF-1α and NRF2 as therapeutic targets.". Redox Biol. 60(): 102603. (2023). (PMID: 36634466).
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  8. Cuadrado, A.; Dinkova-Kostova, A.T.; Mann, G.E. "Introduction to Special Issue on "Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases".". Free Radic Biol Med. (): . (2022). (PMID: 36586454).
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  9. Fernández-Ginés, R.; Encinar, J.A.; Hayes, J.D.; Oliva, B.; Rodríguez-Franco, M.I.; Rojo, A.I.; Cuadrado, A. "Corrigendum to "An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver" [Redox Biol. 55 (2022) 102396/PMID: 35839629].". Redox Biol. 55(): 102428. (2022). (PMID: 35931641).
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  10. Jiménez-Villegas, J.; Kirby, J.; Mata, A.; Cadenas, S.; Turner, M.R.; Malaspina, A.; Shaw, P.J.; Cuadrado, A.; Rojo, A.I. "Dipeptide Repeat Pathology in C9orf72-ALS Is Associated with Redox, Mitochondrial and NRF2 Pathway Imbalance.". Antioxidants (Basel). 11(10): . (2022). (PMID: 36290620).
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  11. Crisman, E.; Duarte, P.; Dauden, E.; Cuadrado, A.; Rodríguez-Franco, M.I.; López, M.G.; León, R. "KEAP1-NRF2 protein-protein interaction inhibitors: Design, pharmacological properties and therapeutic potential.". Med Res Rev. (): . (2022). (PMID: 36086898).
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  12. Kopacz, A.; Rojo, A.I.; Patibandla, C.; Lastra-Martínez, D.; Piechota-Polanczyk, A.; Kloska, D.; Jozkowicz, A.; Sutherland, C.; Cuadrado, A.; Grochot-Przeczek, A. "Overlooked and valuable facts to know in the NRF2/KEAP1 field.". Free Radic Biol Med. 192(): 37-49. (2022). (PMID: 36100148).
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  13. Srivastava, R.; Fernández-Ginés, R.; Encinar, J.A.; Cuadrado, A.; Wells, G. "The current status and future prospects for therapeutic targeting of KEAP1-NRF2 and β-TrCP-NRF2 interactions in cancer chemoresistance.". Free Radic Biol Med. (): . (2022). (PMID: 36181972).
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  14. Manda, G.; Milanesi, E.; Genc, S.; Niculite, C.M.; Neagoe, I.V.; Tastan, B.; Dragnea, E.M.; Cuadrado, A. "Pros and cons of NRF2 activation as adjunctive therapy in rheumatoid arthritis.". Free Radic Biol Med. (): . (2022). (PMID: 35964840).
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  15. Fernández-Ginés, R.; Encinar, J.A.; Hayes, J.D.; Oliva, B.; Rodríguez-Franco, M.I.; Rojo, A.I.; Cuadrado, A. "An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver.". Redox Biol. 55(): 102396. (2022). (PMID: 35839629).
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  16. Uribe-Carretero, E.; Martinez-Chacón, G.; Yakhine-Diop, S.M.S.; Duque-González, G.; Rodríguez-Arribas, M.; Alegre-Cortés, E.; Paredes-Barquero, M.; Canales-Cortés, S.; Pizarro-Estrella, E.; Cuadrado, A.; González-Polo, R.A.; Fuentes, J.M.; Niso-Santano, M. "Loss of KEAP1 Causes an Accumulation of Nondegradative Organelles.". Antioxidants (Basel). 11(7): . (2022). (PMID: 35883891).
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  17. Val-Blasco, A.; Prieto, P.; Jaén, R.I.; Gil-Fernández, M.; Pajares, M.; Domenech, N.; Terrón, V.; Tamayo, M.; Jorge, I.; Vázquez, J.; Bueno-Sen, A.; Vallejo-Cremades, M.T.; Pombo-Otero, J.; Sanchez-García, S.; Ruiz-Hurtado, G.; Gómez, A.M.; Zaragoza, C.; Crespo-Leiro, M.G.; López-Collazo, E.; Cuadrado, A.; Delgado, C.; Boscá, L.; Fernández-Velasco, M. "Specialized Proresolving Mediators Protect Against Experimental Autoimmune Myocarditis by Modulating Ca2+ Handling and NRF2 Activation.". JACC Basic Transl Sci. 7(6): 544-560. (2022). (PMID: 35818504).
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  18. Cucos, C.A.; Milanesi, E.; Dobre, M.; Musat, I.A.; Manda, G.; Cuadrado, A. "Altered Blood and Brain Expression of Inflammation and Redox Genes in Alzheimer's Disease, Common to APPV717I × TAUP301L Mice and Patients.". Int J Mol Sci. 23(10): . (2022). (PMID: 35628609).
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  19. Bayo Jimenez, M.T.; Frenis, K.; Hahad, O.; Steven, S.; Cohen, G.; Cuadrado, A.; Münzel, T.; Daiber, A. "Protective actions of nuclear factor erythroid 2-related factor 2 (NRF2) and downstream pathways against environmental stressors.". Free Radic Biol Med. (): . (2022). (PMID: 35613665).
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  20. Lastra, D.; Escoll, M.; Cuadrado, A. "Transcription Factor NRF2 Participates in Cell Cycle Progression at the Level of G1/S and Mitotic Checkpoints.". Antioxidants (Basel). 11(5): . (2022). (PMID: 35624810).
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  21. Duarte, P.; Michalska, P.; Crisman, E.; Cuadrado, A.; León, R. "Novel Series of Dual NRF2 Inducers and Selective MAO-B Inhibitors for the Treatment of Parkinson's Disease.". Antioxidants (Basel). 11(2): . (2022). (PMID: 35204129).
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  22. Milanesi, E.; Dobre, M.; Cucos, C.A.; Rojo, A.I.; Jiménez-Villegas, J.; Capetillo-Zarate, E.; Matute, C.; Piñol-Ripoll, G.; Manda, G.; Cuadrado, A. "Whole Blood Expression Pattern of Inflammation and Redox Genes in Mild Alzheimer's Disease.". J Inflamm Res. 14(): 6085-6102. (2021). (PMID: 34848989).
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  23. Cuadrado, A. "Brain-Protective Mechanisms of Transcription Factor NRF2: Toward a Common Strategy for Neurodegenerative Diseases.". Annu Rev Pharmacol Toxicol. (): . (2021). (PMID: 34637322).
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  24. García-Yagüe, Á.J.; Lastres-Becker, I.; Stefanis, L.; Vassilatis, D.K.; Cuadrado, A. "α-Synuclein Induces the GSK-3-Mediated Phosphorylation and Degradation of NURR1 and Loss of Dopaminergic Hallmarks.". Mol Neurobiol. (): . (2021). (PMID: 34609698).
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  25. Milanesi, E.; Cucos, C.A.; Matias-Guiu, J.A.; Piñol-Ripoll, G.; Manda, G.; Dobre, M.; Cuadrado, A. "Reduced Blood RGS2 Expression in Mild Cognitive Impairment Patients.". Front Aging Neurosci. 13(): 738244. (2021). (PMID: 34658840).
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  26. Jiménez-Villegas, J.; Ferraiuolo, L.; Mead, R.J.; Shaw, P.J.; Cuadrado, A.; Rojo, A.I. "NRF2 as a therapeutic opportunity to impact in the molecular roadmap of ALS.". Free Radic Biol Med. 173(): 125-141. (2021). (PMID: 34314817).
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  27. Milanesi, E.; Manda, G.; Dobre, M.; Codrici, E.; Neagoe, I.V.; Popescu, B.O.; Bajenaru, O.A.; Spiru, L.; Tudose, C.; Prada, G.I.; Davidescu, E.I.; Piñol-Ripoll, G.; Cuadrado, A. "Distinctive Under-Expression Profile of Inflammatory and Redox Genes in the Blood of Elderly Patients with Cardiovascular Disease.". J Inflamm Res. 14(): 429-442. (2021). (PMID: 33658823).
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  28. Klionsky, D.J.; [ .., ].; Bartolome, A.; [ .., ].; Cuadrado, A.; [ .., ].; Escalante, R.; [ .., ].; García-Sanz, P.; [ .., ].; Lastres-Becker, I.; [ .., ].; León, Y.; [ .., ].; Martin-Sanz, P.; [ .., ].; Pajares, M.; [ .., ].; Rojo, A.I.; [ .., ].; Valverde, A.M.; [ .., ].; Varela-Nieto, I.; [ .., ].; Villalobo, A.; [ .., ].; Vincent, O.; [ .., ].; Tong, C.K. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).". Autophagy. (): 1-382. (2021). (PMID: 33634751).
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  29. Casas, A.I.; Nogales, C.; Mucke, H.A.M.; Petraina, A.; Cuadrado, A.; Rojo, A.I.; Ghezzi, P.; Jaquet, V.; Augsburger, F.; Dufrasne, F.; Soubhye, J.; Deshwal, S.; Di Sante, M.; Kaludercic, N.; Di Lisa, F.; Schmidt, H.H.H.W. "On the Clinical Pharmacology of Reactive Oxygen Species.". Pharmacol. Rev.. 72(4): 801-828. (2020). (PMID: 32859763).
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  30. Robledinos-Antón, N.; Escoll, M.; Guan, K.L.; Cuadrado, A. "TAZ Represses the Neuronal Commitment of Neural Stem Cells.". Cells. 9(10): . (2020). (PMID: 33023162).
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  31. Shi, L.; Winchester, L.M.; Liu, B.Y.; Killick, R.; Ribe, E.M.; Westwood, S.; Baird, A.L.; Buckley, N.J.; Hong, S.; Dobricic, V.; Kilpert, F.; Franke, A.; Kiddle, S.; Sattlecker, M.; Dobson, R.; Cuadrado, A.; Hye, A.; Ashton, N.J.; Morgan, A.R.; Bos, I.; Vos, S.J.B.; Ten Kate, M.; Scheltens, P.; Vandenberghe, R.; Gabel, S.; Meersmans, K.; Engelborghs, S.; De Roeck, E.E.; Sleegers, K.; Frisoni, G.B.; Blin, O.; Richardson, J.C.; Bordet, R.; Molinuevo, J.L.; Rami, L.; Wallin, A.; Kettunen, P.; Tsolaki, M.; Verhey, F.; Lleó, A.; Alcolea, D.; Popp, J.; Peyratout, G.; Martinez-Lage, P.; Tainta, M.; Johannsen, P.; Teunissen, C.E.; Freund-Levi, Y.; Frölich, L.; Legido-Quigley, C.; Barkhof, F.; Blennow, K.; Rasmussen, K.L.; Nordestgaard, B.G.; Frikke-Schmidt, R.; Nielsen, S.F.; Soininen, H.; Vellas, B.; Kloszewska, I.; Mecocci, P.; Zetterberg, H.; Morgan, B.P.; Streffer, J.; Visser, P.J.; Bertram, L.; Nevado-Holgado, A.J.; Lovestone, S. "Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology.". J. Alzheimers Dis.. (): . (2020). (PMID: 32831200).
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  32. Duarte, P.; Cuadrado, A.; León, R. "Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches.". Handb Exp Pharmacol. (): . (2020). (PMID: 32852645).
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  33. Lastra, D.; Fernández-Ginés, R.; Manda, G.; Cuadrado, A. "Perspectives on the Clinical Development of NRF2-Targeting Drugs.". Handb Exp Pharmacol. (): . (2020). (PMID: 32776282).
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  34. Escoll, M.; Lastra, D.; Robledinos-Antón, N.; Wandosell, F.; Antón, I.M.; Cuadrado, A. "WIP Modulates Oxidative Stress through NRF2/KEAP1 in Glioblastoma Cells.". Antioxidants (Basel). 9(9): . (2020). (PMID: 32825452).
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  35. Cuadrado, A.; Pajares, M.; Benito, C.; Jiménez-Villegas, J.; Escoll, M.; Fernández-Ginés, R.; Garcia Yagüe, A.J.; Lastra, D.; Manda, G.; Rojo, A.I.; Dinkova-Kostova, A.T. "Can Activation of NRF2 Be a Strategy against COVID-19?". Trends Pharmacol. Sci.. (): . (2020). (PMID: 32711925).
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  36. Pajares, M.; I Rojo, A.; Manda, G.; Boscá, L.; Cuadrado, A. "Inflammation in Parkinson's Disease: Mechanisms and Therapeutic Implications.". Cells. 9(7): . (2020). (PMID: 32674367).
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  37. Martin-Hurtado, A.; Lastres-Becker, I.; Cuadrado, A.; Garcia-Gonzalo, F.R. "NRF2 and Primary Cilia: An Emerging Partnership.". Antioxidants (Basel). 9(6): . (2020). (PMID: 32498260).
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  38. Manda, G.; Rojo, A.I.; Martínez-Klimova, E.; Pedraza-Chaverri, J.; Cuadrado, A. "Nordihydroguaiaretic Acid: From Herbal Medicine to Clinical Development for Cancer and Chronic Diseases.". Front Pharmacol. 11(): 151. (2020). (PMID: 32184727).
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  39. Escoll, M.; Lastra, D.; Pajares, M.; Robledinos-Antón, N.; Rojo, A.I.; Fernández-Ginés, R.; Mendiola, M.; Martínez-Marín, V.; Esteban, I.; López-Larrubia, P.; Gargini, R.; Cuadrado, A. "Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomas.". Redox Biol. 30(): 101425. (2020). (PMID: 31918259).
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  40. Herrera-Arozamena, C.; Estrada-Valencia, M.; Pérez, C.; Lagartera, L.; Morales-García, J.A.; Pérez-Castillo, A.; Franco-Gonzalez, J.F.; Michalska, P.; Duarte, P.; León, R.; López, M.G.; Mills, A.; Gago, F.; García-Yagüe, Á.J.; Fernández-Ginés, R.; Cuadrado, A.; Rodríguez-Franco, M.I. "Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties.". Eur J Med Chem. 190(): 112090. (2020). (PMID: 32018096).
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  41. Michalska, P.; Buendia, I.; Duarte, P.; FernandezMendivil, C.; Negredo, P.; Cuadrado, A.; López, M.G.; Leon, R. "Melatonin-sulforaphane hybrid ITH12674 attenuates glial response in vivo by blocking LPS binding to MD2 and receptor oligomerization.". Pharmacol. Res.. (): 104597. (2019). (PMID: 31838078).
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  42. Martin-Hurtado, A.; Martin-Morales, R.; Robledinos-Antón, N.; Blanco, R.; Palacios-Blanco, I.; Lastres-Becker, I.; Cuadrado, A.; Garcia-Gonzalo, F.R. "NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling.". Sci Rep. 9(1): 13896. (2019). (PMID: 31554934).
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  43. Robledinos-Antón, N.; Fernández-Ginés, R.; Manda, G.; Cuadrado, A. "Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development.". Oxid Med Cell Longev. 2019(): 9372182. (2019). (PMID: 31396308).
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  44. Cuadrado, A.; Rojo, A.I.; Wells, G.; Hayes, J.D.; Cousin, S.P.; Rumsey, W.L.; Attucks, O.C.; Franklin, S.; Levonen, A.L.; Kensler, T.W.; Dinkova-Kostova, A.T. "Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases.". Nat Rev Drug Discov. 18(4): 295-317. (2019). (PMID: 30610225).
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  45. Manda, G.; Hinescu, M.E.; Neagoe, I.V.; Ferreira, L.F.V.; Boscencu, R.; Vasos, P.; Basaga, S.H.; Cuadrado, A. "Emerging Therapeutic Targets in Oncologic Photodynamic Therapy.". Curr. Pharm. Des.. 24(44): 5268-5295. (2018). (PMID: 30674246).
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  46. Rojo, A.I.; Pajares, M.; García-Yagüe, A.J.; Buendia, I.; Van Leuven, F.; Yamamoto, M.; López, M.G.; Cuadrado, A. "Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy.". Redox Biol. 18(): 173-180. (2018). (PMID: 30029164).
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  47. Pajares, M.; Rojo, A.I.; Arias, E.; Díaz-Carretero, A.; Cuervo, A.M.; Cuadrado, A. "Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A.". Autophagy. 14(8): 1310-1322. (2018). (PMID: 29950142).
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  48. Cuadrado, A.; Manda, G.; Hassan, A.; Alcaraz, M.J.; Barbas, C.; Daiber, A.; Ghezzi, P.; León, R.; López, M.G.; Oliva, B.; Pajares, M.; Rojo, A.I.; Robledinos-Antón, N.; Valverde, A.M.; Guney, E.; Schmidt, H.H.H.W. "Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach.". Pharmacol. Rev.. 70(2): 348-383. (2018). (PMID: 29507103).
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  49. Pajares, M.; Cuadrado, A.; Engedal, N.; Jirsova, Z.; Cahova, M. "The Role of Free Radicals in Autophagy Regulation: Implications for Ageing.". Oxid Med Cell Longev. 2018(): 2450748. (2018). (PMID: 29682156).
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  50. Cuadrado, A.; Kügler, S.; Lastres-Becker, I. "Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy.". Redox Biol. 14(): 522-534. (2017). (PMID: 29121589).
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  51. Sellers, K.J.; Elliott, C.; Jackson, J.; Ghosh, A.; Ribe, E.; Rojo-Sanchís, A.; Jarosz-Griffiths, H.H.; Watson, I.A.; Xia, W.; Semenov, M.; Morin, P.; Hooper, N.M.; Porter, R.; Preston, J.; Al-Shawi, R.; Baillie, G.; Lovestone, S.; Cuadrado, A.; Harte, M.; Simons, P.; Srivastava, D.P.; Killick, R. "Amyloid beta synaptotoxicity is Wnt-planar cell polarity dependent and blocked by fasudil.". Alzheimers Dement. (): . (2017). (PMID: 29055813).
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  52. Egea, J.; Fabregat, I.; Frapart, Y.M.; Ghezzi, P.; Görlach, A.; Kietzmann, T.; Kubaichuk, K.; Knaus, U.G.; Lopez, M.G.; Olaso-Gonzalez, G.; Petry, A.; Schulz, R.; Vina, J.; Winyard, P.; Abbas, K.; Ademowo, O.S.; Afonso, C.B.; Andreadou, I.; Antelmann, H.; Antunes, F.; Aslan, M.; Bachschmid, M.M.; Barbosa, R.M.; Belousov, V.; Berndt, C.; Bernlohr, D.; Bertrán, E.; Bindoli, A.; Bottari, S.P.; Brito, P.M.; Carrara, G.; Casas, A.I.; Chatzi, A.; Chondrogianni, N.; Conrad, M.; Cooke, M.S.; Costa, J.G.; Cuadrado, A.; My-Chan Dang, P.; De Smet, B.; Debelec-Butuner, B.; Dias, I.H.K.; Dunn, J.D.; Edson, A.J.; El Assar, M.; El-Benna, J.; Ferdinandy, P.; Fernandes, A.S.; Fladmark, K.E.; Förstermann, U.; Giniatullin, R.; Giricz, Z.; Görbe, A.; Griffiths, H.; Hampl, V.; Hanf, A.; Herget, J.; Hernansanz-Agustín, P.; Hillion, M.; Huang, J.; Ilikay, S.; Jansen-Dürr, P.; Jaquet, V.; Joles, J.A.; Kalyanaraman, B.; Kaminskyy, D.; Karbaschi, M.; Kleanthous, M.; Klotz, L.O.; Korac, B.; Korkmaz, K.S.; Koziel, R.; Kračun, D.; Krause, K.H.; Křen, V.; Krieg, T.; Laranjinha, J.; Lazou, A.; Li, H.; Martínez-Ruiz, A.; Matsui, R.; McBean, G.J.; Meredith, S.P.; Messens, J.; Miguel, V.; Mikhed, Y.; Milisav, I.; Milković, L.; Miranda-Vizuete, A.; Mojović, M.; Monsalve, M.; Mouthuy, P.A.; Mulvey, J.; Münzel, T.; Muzykantov, V.; Nguyen, I.T.N.; Oelze, M.; Oliveira, N.G.; Palmeira, C.M.; Papaevgeniou, N.; Pavićević, A.; Pedre, B.; Peyrot, F.; Phylactides, M.; Pircalabioru, G.G.; Pitt, A.R.; Poulsen, H.E.; Prieto, I.; Rigobello, M.P.; Robledinos-Antón, N.; Rodríguez-Mañas, L.; Rolo, A.P.; Rousset, F.; Ruskovska, T.; Saraiva, N.; Sasson, S.; Schröder, K.; Semen, K.; Seredenina, T.; Shakirzyanova, A.; Smith, G.L.; Soldati, T.; Sousa, B.C.; Spickett, C.M.; Stancic, A.; Stasia, M.J.; Steinbrenner, H.; Stepanić, V.; Steven, S.; Tokatlidis, K.; Tuncay, E.; Turan, B.; Ursini, F.; Vacek, J.; Vajnerova, O.; Valentová, K.; Van Breusegem, F.; Varisli, L.; Veal, E.A.; Yalçın, A.S.; Yelisyeyeva, O.; Žarković, N.; Zatloukalová, M.; Zielonka, J.; Touyz, R.M.; Papapetropoulos, A.; Grune, T.; Lamas, S.; Schmidt, H.H.H.W.; Di Lisa, F.; Daiber, A. "Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162].". Redox Biol. (): . (2017). (PMID: 29107648).
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  53. Rojo, A.I.; Pajares, M.; Rada, P.; Nuñez, A.; Nevado-Holgado, A.J.; Killik, R.; Van Leuven, F.; Ribe, E.; Lovestone, S.; Yamamoto, M.; Cuadrado, A. "NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology.". Redox Biol. 13(): 444-451. (2017). (PMID: 28704727).
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  54. Robledinos-Antón, N.; Rojo, A.I.; Ferreiro, E.; Núñez, Á.; Krause, K.H.; Jaquet, V.; Cuadrado, A. "Transcription factor NRF2 controls the fate of neural stem cells in the subgranular zone of the hippocampus.". Redox Biol. 13(): 393-401. (2017). (PMID: 28667908).
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  55. Tobón-Velasco, J.C.; Limón-Pacheco, J.H.; Orozco-Ibarra, M.; Macías-Silva, M.; Vázquez-Victorio, G.; Cuevas, E.; Ali, S.F.; Cuadrado, A.; Pedraza-Chaverrí, J.; Santamaría, A. "Retraction notice to "RETRACTED: 6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors" [Toxicology (2013) 109 - 119].". Toxicology. 390(): 167. (2017). (PMID: 28991642).
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  56. Escoll, M.; Gargini, R.; Cuadrado, A.; Anton, I.M.; Wandosell, F. "Mutant p53 oncogenic functions in cancer stem cells are regulated by WIP through YAP/TAZ.". Oncogene. 36(25): 3515-3527. (2017). (PMID: 28166194).
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  57. Ghezzi, P.; Floridi, L.; Boraschi, D.; Cuadrado, A.; Manda, G.; Levic, S.; D'Acquisto, F.; Hamilton, A.; Athersuch, T.J.; Selley, L. "Oxidative Stress and Inflammation Induced by Environmental and Psychological Stressors: A Biomarker Perspective.". Antioxid. Redox Signal.. (): . (2017). (PMID: 28494612).
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  58. Egea, J.; Fabregat, I.; Frapart, Y.M.; Ghezzi, P.; Görlach, A.; Kietzmann, T.; Kubaichuk, K.; Knaus, U.G.; Lopez, M.G.; Olaso-Gonzalez, G.; Petry, A.; Schulz, R.; Vina, J.; Winyard, P.; Abbas, K.; Ademowo, O.S.; Afonso, C.B.; Andreadou, I.; Antelmann, H.; Antunes, F.; Aslan, M.; Bachschmid, M.M.; Barbosa, R.M.; Belousov, V.; Berndt, C.; Bernlohr, D.; Bertrán, E.; Bindoli, A.; Bottari, S.P.; Brito, P.M.; Carrara, G.; Casas, A.I.; Chatzi, A.; Chondrogianni, N.; Conrad, M.; Cooke, M.S.; Costa, J.G.; Cuadrado, A.; My-Chan Dang, P.; De Smet, B.; Debelec-Butuner, B.; Dias, I.H.K.; Dunn, J.D.; Edson, A.J.; El Assar, M.; El-Benna, J.; Ferdinandy, P.; Fernandes, A.S.; Fladmark, K.E.; Förstermann, U.; Giniatullin, R.; Giricz, Z.; Görbe, A.; Griffiths, H.; Hampl, V.; Hanf, A.; Herget, J.; Hernansanz-Agustín, P.; Hillion, M.; Huang, J.; Ilikay, S.; Jansen-Dürr, P.; Jaquet, V.; Joles, J.A.; Kalyanaraman, B.; Kaminskyy, D.; Karbaschi, M.; Kleanthous, M.; Klotz, L.O.; Korac, B.; Korkmaz, K.S.; Koziel, R.; Kračun, D.; Krause, K.H.; Křen, V.; Krieg, T.; Laranjinha, J.; Lazou, A.; Li, H.; Martínez-Ruiz, A.; Matsui, R.; McBean, G.J.; Meredith, S.P.; Messens, J.; Miguel, V.; Mikhed, Y.; Milisav, I.; Milković, L.; Miranda-Vizuete, A.; Mojović, M.; Monsalve, M.; Mouthuy, P.A.; Mulvey, J.; Münzel, T.; Muzykantov, V.; Nguyen, I.T.N.; Oelze, M.; Oliveira, N.G.; Palmeira, C.M.; Papaevgeniou, N.; Pavićević, A.; Pedre, B.; Peyrot, F.; Phylactides, M.; Pircalabioru, G.G.; Pitt, A.R.; Poulsen, H.E.; Prieto, I.; Rigobello, M.P.; Robledinos-Antón, N.; Rodríguez-Mañas, L.; Rolo, A.P.; Rousset, F.; Ruskovska, T.; Saraiva, N.; Sasson, S.; Schröder, K.; Semen, K.; Seredenina, T.; Shakirzyanova, A.; Smith, G.L.; Soldati, T.; Sousa, B.C.; Spickett, C.M.; Stancic, A.; Stasia, M.J.; Steinbrenner, H.; Stepanić, V.; Steven, S.; Tokatlidis, K.; Tuncay, E.; Turan, B.; Ursini, F.; Vacek, J.; Vajnerova, O.; Valentová, K.; Van Breusegem, F.; Varisli, L.; Veal, E.A.; Yalçın, A.S.; Yelisyeyeva, O.; Žarković, N.; Zatloukalová, M.; Zielonka, J.; Touyz, R.M.; Papapetropoulos, A.; Grune, T.; Lamas, S.; Schmidt, H.H.H.W.; Di Lisa, F.; Daiber, A. "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).". Redox Biol. 13(): 94-9162. (2017). (PMID: 28577489).
    spacer

  59. Nayernia, Z.; Colaianna, M.; Robledinos-Antón, N.; Gutzwiller, E.; Sloan-Béna, F.; Stathaki, E.; Hibaoui, Y.; Cuadrado, A.; Hescheler, J.; José Stasia, M.; Saric, T.; Jaquet, V.; Krause, K.H. "Decreased neural precursor cell pool in NADPH oxidase 2-deficiency: From mouse brain to neural differentiation of patient derived iPSC.". Redox Biol. 13(): 82-93. (2017). (PMID: 28575744).
    spacer

  60. Gameiro, I.; Michalska, P.; Tenti, G.; Cores, Á.; Buendia, I.; Rojo, A.I.; Georgakopoulos, N.D.; Hernández-Guijo, J.M.; Teresa Ramos, M.; Wells, G.; López, M.G.; Cuadrado, A.; Menéndez, J.C.; León, R. "Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's disease.". Sci Rep. 7(): 45701. (2017). (PMID: 28361919).
    spacer

  61. Tobón-Velasco, J.C.; Vázquez-Victorio, G.; Macías-Silva, M.; Cuevas, E.; Ali, S.F.; Maldonado, P.D.; González-Trujano, M.E.; Cuadrado, A.; José Pedraza-Chaverrí, .; Santamaría, A. "Retraction notice toS-Allyl cysteine protects against 6-hydroxydopamine-induced neurotoxicity in the rat striatum: involvement of Nrf2 transcription factor activation and modulation of signaling kinase cascades [FRB 53/5 (2012) 1024 - 1040].". Free Radic. Biol. Med.. 104(): 382. (2017). (PMID: 28237391).
    spacer

  62. Pajares, M.; Cuadrado, A.; Rojo, A.I. "Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases.". Redox Biol. 11(): 543-553. (2017). (PMID: 28104575).
    spacer

  63. Pajares, M.; Jiménez-Moreno, N.; García-Yagüe, Á.J.; Escoll, M.; de Ceballos, M.L.; Van Leuven, F.; Rábano, A.; Yamamoto, M.; Rojo, A.I.; Cuadrado, A. "Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes.". Autophagy. 12(10): 1902-1916. (2016). (PMID: 27427974).
    spacer

  64. Navarro, E.; Gonzalez-Lafuente, L.; Perez-Liebana, I.; Buendia, I.; López-Bernardo, E.; Sanchez-Ramos, C.; Prieto, I.; Cuadrado, A.; Satrustegui, J.; Cadenas, S.; Monsalve, M.; Lopez, M.G. "Heme-oxygenase I and PCG-1α regulate mitochondrial biogenesis via microglial activation of alpha7 nicotinic acetylcholine receptors using PNU282987.". Antioxid. Redox Signal.. (): . (2016). (PMID: 27554853).
    spacer

  65. Freitas, A.E.; Egea, J.; Buendia, I.; Gómez-Rangel, V.; Parada, E.; Navarro, E.; Casas, A.I.; Wojnicz, A.; Ortiz, J.A.; Cuadrado, A.; Ruiz-Nuño, A.; Rodrigues, A.L.S.; Lopez, M.G. "Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice.". Mol. Neurobiol.. 53(5): 3030-3045. (2016). (PMID: 25966970).
    spacer

  66. Lastres-Becker, I.; García-Yagüe, A.J.; Scannevin, R.H.; Casarejos, M.J.; Kügler, S.; Rábano, A.; Cuadrado, A. "Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease.". Antioxid. Redox Signal.. 25(2): 61-77. (2016). (PMID: 27009601).
    spacer

  67. Schmidt, H.H.; Stocker, R.; Paulsen, G.; Ghezzi, P.; Riley, D.; Daiber, A.; Cuadrado, A. "Response to I. Batinic-Haberle et al.". Antioxid. Redox Signal.. 24(9): 525-526. (2016). (PMID: 27003744).
    spacer

  68. Pajares, M.; Jiménez-Moreno, N.; Dias, I.H.; Debelec, B.; Vucetic, M.; Fladmark, K.E.; Basaga, H.; Ribaric, S.; Milisav, I.; Cuadrado, A. "Redox control of protein degradation.". Redox Biol. 6(): 409-420. (2015). (PMID: 26381917).
    spacer

  69. Schmidt, H.H.; Stocker, R.; Vollbracht, C.; Paulsen, G.; Riley, D.; Daiber, A.; Cuadrado, A. "Antioxidants in Translational Medicine.". Antioxid. Redox Signal.. 23(14): 1130-1143. (2015). (PMID: 26154592).
    spacer

  70. Frijhoff, J.; Winyard, P.G.; Zarkovic, N.; Davies, S.S.; Stocker, R.; Cheng, D.; Knight, A.R.; Taylor, E.L.; Oettrich, J.; Ruskovska, T.; Gasparovic, A.C.; Cuadrado, A.; Weber, D.; Poulsen, H.E.; Grune, T.; Schmidt, H.H.; Ghezzi, P. "Clinical Relevance of Biomarkers of Oxidative Stress.". Antioxid. Redox Signal.. 23(14): 1144-1170. (2015). (PMID: 26415143).
    spacer

  71. Dao, V.T.; Casas, A.I.; Maghzal, G.J.; Seredenina, T.; Kaludercic, N.; Robledinos-Anton, N.; Di Lisa, F.; Stocker, R.; Ghezzi, P.; Jaquet, V.; Cuadrado, A.; Schmidt, H.H. "Pharmacology and Clinical Drug Candidates in Redox Medicine.". Antioxid. Redox Signal.. 23(14): 1113-1129. (2015). (PMID: 26415051).
    spacer

  72. Casas, A.I.; Dao, V.T.; Daiber, A.; Maghzal, G.J.; Di Lisa, F.; Kaludercic, N.; Leach, S.; Cuadrado, A.; Jaquet, V.; Seredenina, T.; Krause, K.H.; López, M.G.; Stocker, R.; Ghezzi, P.; Schmidt, H.H. "Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications.". Antioxid. Redox Signal.. 23(14): 1171-1185. (2015). (PMID: 26583264).
    spacer

  73. Prieto, P.; Rosales-Mendoza, C.E.; Terrón, V.; Toledano, V.; Cuadrado, A.; López-Collazo, E.; Bannenberg, G.; Martín-Sanz, P.; Fernández-Velasco, M.; Boscá, L. "Activation of autophagy in macrophages by pro-resolving lipid mediators.". Autophagy. 11(10): 1729-1744. (2015). (PMID: 26506892).
    spacer

  74. González-Rodríguez, Á.; Santamaría, B.; Mas-Gutierrez, J.A.; Rada, P.; Fernández-Millán, E.; Pardo, V.; Álvarez, C.; Cuadrado, A.; Ros, M.; Serrano, M.; Valverde, Á.M. "Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1-independent manner.". Mol Nutr Food Res. 59(8): 1431-1442. (2015). (PMID: 25808216).
    spacer

  75. Valdecantos, M.P.; Prieto-Hontoria, P.L.; Pardo, V.; Módol, T.; Santamaría, B.; Weber, M.; Herrero, L.; Serra, D.; Muntané, J.; Cuadrado, A.; Moreno-Aliaga, M.J.; Alfredo Martínez, J.; Valverde, Á.M. "Essential role of Nrf2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes.". Free Radic. Biol. Med.. 84(): 263-278. (2015). (PMID: 25841776).
    spacer

  76. Delgado-Buenrostro, N.L.; Medina-Reyes, E.I.; Lastres-Becker, I.; Freyre-Fonseca, V.; Ji, Z.; Hernández-Pando, R.; Marquina, B.; Pedraza-Chaverri, J.; Espada, S.; Cuadrado, A.; Chirino, Y.I. "Nrf2 protects the lung against inflammation induced by titanium dioxide nanoparticles: A positive regulator role of Nrf2 on cytokine release.". Environ. Toxicol.. 30(7): 782-792. (2015). (PMID: 24615891).
    spacer

  77. Cuadrado, A. "Transcription Factor Nrf2: a novel target to modulate inflammatory and neuroprotective responses in Parkinson's disease.". Springerplus. 4(Suppl 1): L43. (2015). (PMID: 27386205).
    spacer

  78. Cuadrado, A. "Structural and functional characterization of NRF2 degradation by glycogen synthase kinase 3/β-TrCP.". Free Radic. Biol. Med.. (): . (2015). (PMID: 25937177).
    spacer

  79. Rada, P.; Rojo, A.I.; Offergeld, A.; Feng, G.J.; Velasco-Martín, J.P.; González-Sancho, J.M.; Valverde, Á.M.; Dale, T.; Regadera, J.; Cuadrado, A. "WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes.". Antioxid. Redox Signal.. 22(7): 555-571. (2015). (PMID: 25336178).
    spacer

  80. Rojo, A.I.; Rada, P.; Mendiola, M.; Ortega-Molina, A.; Wojdyla, K.; Rogowska-Wrzesinska, A.; Hardisson, D.; Serrano, M.; Cuadrado, A. "The PTEN/NRF2 axis promotes human carcinogenesis.". Antioxid. Redox Signal.. 21(18): 2498-2514. (2014). (PMID: 24892215).
    spacer

  81. Ibáñez, L.; Ferrándiz, M.L.; Brines, R.; Guede, D.; Cuadrado, A.; Alcaraz, M.J. "Effects of Nrf2 deficiency on bone microarchitecture in an experimental model of osteoporosis.". Oxid Med Cell Longev. 2014(): 726590. (2014). (PMID: 25120886).
    spacer

  82. Cuadrado, A.; Martín-Moldes, Z.; Ye, J.; Lastres-Becker, I. "Transcription factors NRF2 and NF-κB are coordinated effectors of the Rho family, GTP-binding protein RAC1 during inflammation.". J. Biol. Chem.. 289(22): 15244-15258. (2014). (PMID: 24759106).
    spacer

  83. Lastres-Becker, I.; Innamorato, N.G.; Jaworski, T.; Rábano, A.; Kügler, S.; Van Leuven, F.; Cuadrado, A. "Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis.". Brain. 137(Pt 1): 78-91. (2014). (PMID: 24277722).
    spacer

  84. Martín-de-Saavedra, M.D.; Budni, J.; Cunha, M.P.; Gómez-Rangel, V.; Lorrio, S.; Del Barrio, L.; Lastres-Becker, I.; Parada, E.; Tordera, R.M.; Rodrigues, A.L.; Cuadrado, A.; López, M.G. "Nrf2 participates in depressive disorders through an anti-inflammatory mechanism.". Psychoneuroendocrinology. 38(10): 2010-2022. (2013). (PMID: 23623252).
    spacer

  85. Mobasher, M.A.; González-Rodriguez, A.; Santamaría, B.; Ramos, S.; Martín, M.Á.; Goya, L.; Rada, P.; Letzig, L.; James, L.P.; Cuadrado, A.; Martín-Pérez, J.; Simpson, K.J.; Muntané, J.; Valverde, A.M. "Protein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity.". Cell Death Dis. 4(): e626. (2013). (PMID: 23661004).
    spacer

  86. García-Yagüe, Á.J.; Rada, P.; Rojo, A.I.; Lastres-Becker, I.; Cuadrado, A. "Nuclear import and export signals control the subcellular localization of Nurr1 protein in response to oxidative stress.". J. Biol. Chem.. 288(8): 5506-5517. (2013). (PMID: 23283970).
    spacer

  87. Tobón-Velasco, J.C.; Vázquez-Victorio, G.; Macías-Silva, M.; Cuevas, E.; Ali, S.F.; Maldonado, P.D.; González-Trujano, M.E.; Cuadrado, A.; Pedraza-Chaverrí, J.; Santamaría, A. "S-allyl cysteine protects against 6-hydroxydopamine-induced neurotoxicity in the rat striatum: involvement of Nrf2 transcription factor activation and modulation of signaling kinase cascades.". Free Radic. Biol. Med.. 53(5): 1024-1040. (2012). (PMID: 22781654).
    spacer

  88. Rada, P.; Rojo, A.I.; Evrard-Todeschi, N.; Innamorato, N.G.; Cotte, A.; Jaworski, T.; Tobón-Velasco, J.C.; Devijver, H.; García-Mayoral, M.F.; Van Leuven, F.; Hayes, J.D.; Bertho, G.; Cuadrado, A. "Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis.". Mol. Cell. Biol.. 32(17): 3486-3499. (2012). (PMID: 22751928).
    spacer

  89. Lastres-Becker, I.; Ulusoy, A.; Innamorato, N.G.; Sahin, G.; Rábano, A.; Kirik, D.; Cuadrado, A. "α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease.". Hum. Mol. Genet.. 21(14): 3173-3192. (2012). (PMID: 22513881).
    spacer

  90. Martín-Moreno, A.M.; Brera, B.; Spuch, C.; Carro, E.; García-García, L.; Delgado, M.; Pozo, M.A.; Innamorato, N.G.; Cuadrado, A.; de Ceballos, M.L. "Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice.". J Neuroinflammation. 9(): 8. (2012). (PMID: 22248049).
    spacer

  91. Rojo, A.I.; Medina-Campos, O.N.; Rada, P.; Zúñiga-Toalá, A.; López-Gazcón, A.; Espada, S.; Pedraza-Chaverri, J.; Cuadrado, A. "Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3.". Free Radic. Biol. Med.. 52(2): 473-487. (2012). (PMID: 22142471).
    spacer

  92. Granado, N.; Lastres-Becker, I.; Ares-Santos, S.; Oliva, I.; Martin, E.; Cuadrado, A.; Moratalla, R. "Nrf2 deficiency potentiates methamphetamine-induced dopaminergic axonal damage and gliosis in the striatum.". Glia. 59(12): 1850-1863. (2011). (PMID: 21882243).
    spacer

  93. Maicas, N.; Ferrándiz, M.L.; Brines, R.; Ibáñez, L.; Cuadrado, A.; Koenders, M.I.; van den Berg, W.B.; Alcaraz, M.J. "Deficiency of Nrf2 accelerates the effector phase of arthritis and aggravates joint disease.". Antioxid. Redox Signal.. 15(4): 889-901. (2011). (PMID: 21406003).
    spacer

  94. Martín-Moreno, A.M.; Reigada, D.; Ramírez, B.G.; Mechoulam, R.; Innamorato, N.; Cuadrado, A.; de Ceballos, M.L. "Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer's disease.". Mol. Pharmacol.. 79(6): 964-973. (2011). (PMID: 21350020).
    spacer

  95. Jazwa, A.; Rojo, A.I.; Innamorato, N.G.; Hesse, M.; Fernández-Ruiz, J.; Cuadrado, A. "Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism.". Antioxid. Redox Signal.. 14(12): 2347-2360. (2011). (PMID: 21254817).
    spacer

  96. Rada, P.; Rojo, A.I.; Chowdhry, S.; McMahon, M.; Hayes, J.D.; Cuadrado, A. "SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.". Mol. Cell. Biol.. 31(6): 1121-1133. (2011). (PMID: 21245377).
    spacer

  97. Jazwa, A.; Cuadrado, A. "Targeting heme oxygenase-1 for neuroprotection and neuroinflammation in neurodegenerative diseases.". Curr Drug Targets. 11(12): 1517-1531. (2010). (PMID: 20704549).
    spacer

  98. Espada, S.; Ortega, F.; Molina-Jijón, E.; Rojo, A.I.; Pérez-Sen, R.; Pedraza-Chaverri, J.; Miras-Portugal, M.T.; Cuadrado, A. "The purinergic P2Y(13) receptor activates the Nrf2/HO-1 axis and protects against oxidative stress-induced neuronal death.". Free Radic. Biol. Med.. 49(3): 416-426. (2010). (PMID: 20447456).
    spacer

  99. Innamorato, N.G.; Jazwa, A.; Rojo, A.I.; García, C.; Fernández-Ruiz, J.; Grochot-Przeczek, A.; Stachurska, A.; Jozkowicz, A.; Dulak, J.; Cuadrado, A. "Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1.". PLoS ONE. 5(7): e11838. (2010). (PMID: 20676377).
    spacer

  100. Niso-Santano, M.; González-Polo, R.A.; Bravo-San Pedro, J.M.; Gómez-Sánchez, R.; Lastres-Becker, I.; Ortiz-Ortiz, M.A.; Soler, G.; Morán, J.M.; Cuadrado, A.; Fuentes, J.M.; , . "Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis.". Free Radic. Biol. Med.. 48(10): 1370-1381. (2010). (PMID: 20202476).
    spacer

  101. Rojo, A.I.; Innamorato, N.G.; Martín-Moreno, A.M.; De Ceballos, M.L.; Yamamoto, M.; Cuadrado, A. "Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease.". Glia. 58(5): 588-598. (2010). (PMID: 19908287).
    spacer

  102. Flores, J.A.; Galan-Rodriguez, B.; Rojo, A.I.; Ramiro-Fuentes, S.; Cuadrado, A.; Fernandez-Espejo, E. "Fibroblast growth factor-1 within the ventral tegmental area participates in motor sensitizing effects of morphine.". Neuroscience. 165(1): 198-211. (2010). (PMID: 19819303).
    spacer

  103. Egea, J.; Rosa, A.O.; Lorrio, S.; del Barrio, L.; Cuadrado, A.; López, M.G. "Haeme oxygenase-1 overexpression via nAChRs and the transcription factor Nrf2 has antinociceptive effects in the formalin test.". Pain. 146(1-2): 75-83. (2009). (PMID: 19660867).
    spacer

  104. Espada, S.; Rojo, A.I.; Salinas, M.; Cuadrado, A. "The muscarinic M1 receptor activates Nrf2 through a signaling cascade that involves protein kinase C and inhibition of GSK-3beta: connecting neurotransmission with neuroprotection.". J. Neurochem.. 110(3): 1107-1119. (2009). (PMID: 19558456).
    spacer

  105. Megías, J.; Guillén, M.I.; Clérigues, V.; Rojo, A.I.; Cuadrado, A.; Castejón, M.A.; Gomar, F.; Alcaraz, M.J. "Heme oxygenase-1 induction modulates microsomal prostaglandin E synthase-1 expression and prostaglandin E(2) production in osteoarthritic chondrocytes.". Biochem. Pharmacol.. 77(12): 1806-1813. (2009). (PMID: 19428335).
    spacer

  106. Innamorato, N.G.; Lastres-Becker, I.; Cuadrado, A. "Role of microglial redox balance in modulation of neuroinflammation.". Curr. Opin. Neurol.. 22(3): 308-314. (2009). (PMID: 19359988).
    spacer

  107. Cuadrado, A.; Moreno-Murciano, P.; Pedraza-Chaverri, J. "The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease.". Expert Opin. Ther. Targets. 13(3): 319-329. (2009). (PMID: 19236154).
    spacer

  108. Guzmán-Beltrán, S.; Espada, S.; Orozco-Ibarra, M.; Pedraza-Chaverri, J.; Cuadrado, A. "Nordihydroguaiaretic acid activates the antioxidant pathway Nrf2/HO-1 and protects cerebellar granule neurons against oxidative stress.". Neurosci. Lett.. 447(2-3): 167-171. (2008). (PMID: 18852027).
    spacer

  109. Rojo, A.I.; Rada, P.; Egea, J.; Rosa, A.O.; López, M.G.; Cuadrado, A. "Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death.". Mol. Cell. Neurosci.. 39(1): 125-132. (2008). (PMID: 18619545).
    spacer

  110. Rosa, A.O.; Egea, J.; Lorrio, S.; Rojo, A.I.; Cuadrado, A.; López, M.G. "Nrf2-mediated haeme oxygenase-1 up-regulation induced by cobalt protoporphyrin has antinociceptive effects against inflammatory pain in the formalin test in mice.". Pain. 137(2): 332-339. (2008). (PMID: 17964723).
    spacer

  111. Innamorato, N.G.; Rojo, A.I.; García-Yagüe, A.J.; Yamamoto, M.; de Ceballos, M.L.; Cuadrado, A. "The transcription factor Nrf2 is a therapeutic target against brain inflammation.". J. Immunol.. 181(1): 680-689. (2008). (PMID: 18566435).
    spacer

  112. Cuadrado, A.; Rojo, A.I. "Heme oxygenase-1 as a therapeutic target in neurodegenerative diseases and brain infections.". Curr. Pharm. Des.. 14(5): 429-442. (2008). (PMID: 18289070).
    spacer

  113. Rojo, A.I.; Sagarra, M.R.; Cuadrado, A. "GSK-3beta down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress.". J. Neurochem.. 105(1): 192-202. (2008). (PMID: 18005231).
    spacer

  114. Rojo, A.I.; Cavada, C.; de Sagarra, M.R.; Cuadrado, A. "Chronic inhalation of rotenone or paraquat does not induce Parkinson's disease symptoms in mice or rats.". Exp. Neurol.. 208(1): 120-126. (2007). (PMID: 17880941).
    spacer

  115. Egea, J.; Rosa, A.O.; Cuadrado, A.; García, A.G.; López, M.G. "Nicotinic receptor activation by epibatidine induces heme oxygenase-1 and protects chromaffin cells against oxidative stress.". J. Neurochem.. 102(6): 1842-1852. (2007). (PMID: 17540012).
    spacer

  116. Matesanz, N.; Lafuente, N.; Azcutia, V.; Martín, D.; Cuadrado, A.; Nevado, J.; Rodríguez-Mañas, L.; Sánchez-Ferrer, C.F.; Peiró, C. "Xanthine oxidase-derived extracellular superoxide anions stimulate activator protein 1 activity and hypertrophy in human vascular smooth muscle via c-Jun N-terminal kinase and p38 mitogen-activated protein kinases.". J. Hypertens.. 25(3): 609-618. (2007). (PMID: 17278978).
    spacer

  117. Rojo, A.I.; Montero, C.; Salazar, M.; Close, R.M.; Fernández-Ruiz, J.; Sánchez-González, M.A.; de Sagarra, M.R.; Jackson-Lewis, V.; Cavada, C.; Cuadrado, A. "Persistent penetration of MPTP through the nasal route induces Parkinson's disease in mice.". Eur. J. Neurosci.. 24(7): 1874-1884. (2006). (PMID: 17067291).
    spacer

  118. Rojo, A.I.; Salina, M.; Salazar, M.; Takahashi, S.; Suske, G.; Calvo, V.; de Sagarra, M.R.; Cuadrado, A. "Regulation of heme oxygenase-1 gene expression through the phosphatidylinositol 3-kinase/PKC-zeta pathway and Sp1.". Free Radic. Biol. Med.. 41(2): 247-261. (2006). (PMID: 16814105).
    spacer

  119. Salazar, M.; Rojo, A.I.; Velasco, D.; de Sagarra, R.M.; Cuadrado, A. "Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2.". J. Biol. Chem.. 281(21): 14841-14851. (2006). (PMID: 16551619).
    spacer

  120. Serantes, R.; Arnalich, F.; Figueroa, M.; Salinas, M.; Andrés-Mateos, E.; Codoceo, R.; Renart, J.; Matute, C.; Cavada, C.; Cuadrado, A.; Montiel, C. "Interleukin-1beta enhances GABAA receptor cell-surface expression by a phosphatidylinositol 3-kinase/Akt pathway: relevance to sepsis-associated encephalopathy.". J. Biol. Chem.. 281(21): 14632-14643. (2006). (PMID: 16567807).
    spacer

  121. Marinissen, M.J.; Tanos, T.; Bolós, M.; de Sagarra, M.R.; Coso, O.A.; Cuadrado, A. "Inhibition of heme oxygenase-1 interferes with the transforming activity of the Kaposi sarcoma herpesvirus-encoded G protein-coupled receptor.". J. Biol. Chem.. 281(16): 11332-11346. (2006). (PMID: 16476737).
    spacer

  122. Salinas, M.; Wang, J.; Rosa de Sagarra, M.; Martín, D.; Rojo, A.I.; Martin-Perez, J.; Ortiz de Montellano, P.R.; Cuadrado, A. "Protein kinase Akt/PKB phosphorylates heme oxygenase-1 in vitro and in vivo.". FEBS Lett.. 578(1-2): 90-94. (2004). (PMID: 15581622).
    spacer

  123. Sánchez-Sánchez, N.; Riol-Blanco, L.; de la Rosa, G.; Puig-Kröger, A.; García-Bordas, J.; Martín, D.; Longo, N.; Cuadrado, A.; Cabañas, C.; Corbí, A.L.; Sánchez-Mateos, P.; Rodríguez-Fernández, J.L. "Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells.". Blood. 104(3): 619-625. (2004). (PMID: 15059845).
    spacer

  124. Rojo, A.I.; Salinas, M.; Martín, D.; Perona, R.; Cuadrado, A. "Regulation of Cu/Zn-superoxide dismutase expression via the phosphatidylinositol 3 kinase/Akt pathway and nuclear factor-kappaB.". J. Neurosci.. 24(33): 7324-7334. (2004). (PMID: 15317858).
    spacer

  125. Sánchez-Martín, L.; Sánchez-Sánchez, N.; Gutiérrez-López, M.D.; Rojo, A.I.; Vicente-Manzanares, M.; Pérez-Alvarez, M.J.; Sánchez-Mateos, P.; Bustelo, X.R.; Cuadrado, A.; Sánchez-Madrid, F.; Rodríguez-Fernández, J.L.; Cabañas, C. "Signaling through the leukocyte integrin LFA-1 in T cells induces a transient activation of Rac-1 that is regulated by Vav and PI3K/Akt-1.". J. Biol. Chem.. 279(16): 16194-16205. (2004). (PMID: 14960575).
    spacer

  126. Martin, D.; Rojo, A.I.; Salinas, M.; Diaz, R.; Gallardo, G.; Alam, J.; De Galarreta, C.M.; Cuadrado, A. "Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol.". J. Biol. Chem.. 279(10): 8919-8929. (2004). (PMID: 14688281).
    spacer

  127. Salinas, M.; Diaz, R.; Abraham, N.G.; Ruiz de Galarreta, C.M.; Cuadrado, A. "Nerve growth factor protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a phosphatidylinositol 3-kinase-dependent manner.". J. Biol. Chem.. 278(16): 13898-13904. (2003). (PMID: 12578834).
    spacer

  128. Martin, D.; Salinas, M.; Fujita, N.; Tsuruo, T.; Cuadrado, A. "Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B.". J. Biol. Chem.. 277(45): 42943-42952. (2002). (PMID: 12213802).
    spacer

  129. Conejo, R.; de Alvaro, C.; Benito, M.; Cuadrado, A.; Lorenzo, M. "Insulin restores differentiation of Ras-transformed C2C12 myoblasts by inducing NF-kappaB through an AKT/P70S6K/p38-MAPK pathway.". Oncogene. 21(23): 3739-3753. (2002). (PMID: 12032842).
    spacer

  130. Martín, D.; Salinas, M.; López-Valdaliso, R.; Serrano, E.; Recuero, M.; Cuadrado, A. "Effect of the Alzheimer amyloid fragment Abeta(25-35) on Akt/PKB kinase and survival of PC12 cells.". J. Neurochem.. 78(5): 1000-1008. (2001). (PMID: 11553674).
    spacer

  131. Salinas, M.; Martín, D.; Alvarez, A.; Cuadrado, A. "Akt1/PKBalpha protects PC12 cells against the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium and reduces the levels of oxygen-free radicals.". Mol. Cell. Neurosci.. 17(1): 67-77. (2001). (PMID: 11161470).
    spacer

  132. Salinas, M.; López-Valdaliso, R.; Martín, D.; Alvarez, A.; Cuadrado, A. "Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells.". Mol. Cell. Neurosci.. 15(2): 156-169. (2000). (PMID: 10673324).
    spacer

  133. Murga, C.; Laguinge, L.; Wetzker, R.; Cuadrado, A.; Gutkind, J.S. "Activation of Akt/protein kinase B by G protein-coupled receptors. A role for alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinasegamma.". J. Biol. Chem.. 273(30): 19080-19085. (1998). (PMID: 9668091).
    spacer

  134. Cuadrado, A.; Issing, W.; Fleming, T.P.; Molloy, C.J. "Uneven distribution of protein kinase C-alpha and -beta isozymes in human sarcomas and carcinomas.". J. Cell. Physiol.. 159(3): 434-440. (1994). (PMID: 8188761).
    spacer

  135. Carnero, A.; Cuadrado, A.; del Peso, L.; Lacal, J.C. "Activation of type D phospholipase by serum stimulation and ras-induced transformation in NIH3T3 cells.". Oncogene. 9(5): 1387-1395. (1994). (PMID: 8152799).
    spacer

  136. Cuadrado, A.; Carnero, A.; Dolfi, F.; Jiménez, B.; Lacal, J.C. "Phosphorylcholine: a novel second messenger essential for mitogenic activity of growth factors.". Oncogene. 8(11): 2959-2968. (1993). (PMID: 8414498).
    spacer

  137. Cuadrado, A.; Bruder, J.T.; Heidaran, M.A.; App, H.; Rapp, U.R.; Aaronson, S.A. "H-ras and raf-1 cooperate in transformation of NIH3T3 fibroblasts.". Oncogene. 8(9): 2443-2448. (1993). (PMID: 8361757).
    spacer

  138. Dolfi, F.; Carnero, A.; Cuadrado, A.; Ramponi, G.; Lacal, J.C. "Acylphosphatase synergizes with progesterone during maturation of Xenopus laevis oocytes.". FEBS Lett.. 327(3): 265-270. (1993). (PMID: 8394242).
    spacer

  139. Molloy, C.J.; Fleming, T.P.; Bottaro, D.P.; Cuadrado, A.; Aaronson, S.A. "Platelet-derived growth factor stimulation of GTPase-activating protein tyrosine phosphorylation in control and c-H-ras-expressing NIH 3T3 cells correlates with p21ras activation.". Mol. Cell. Biol.. 12(9): 3903-3909. (1992). (PMID: 1508192).
    spacer

  140. Cánovas, J.L.; Cuadrado, A.; Escalera, M.; Navarrete, M.H. "The probability of G1 cells to enter into S increases with their size while S length decreases with cell enlargement in Allium cepa.". Exp. Cell Res.. 191(2): 163-170. (1990). (PMID: 2257874).
    spacer

  141. Cuadrado, A.; Molloy, C.J. "Overexpression of phospholipase C-gamma in NIH 3T3 fibroblasts results in increased phosphatidylinositol hydrolysis in response to platelet-derived growth factor and basic fibroblast growth factor.". Mol. Cell. Biol.. 10(11): 6069-6072. (1990). (PMID: 2172791).
    spacer

  142. Cuadrado, A. "Increased tyrosine phosphorylation in ras transformed fibroblasts occurs prior to manifestation of the transformed phenotype.". Biochem. Biophys. Res. Commun.. 170(2): 526-532. (1990). (PMID: 2200402).
    spacer

  143. Lacal, J.C.; Cuadrado, A.; Jones, J.E.; Trotta, R.; Burstein, D.E.; Thomson, T.; Pellicer, A. "Regulation of protein kinase C activity in neuronal differentiation induced by the N-ras oncogene in PC-12 cells.". Mol. Cell. Biol.. 10(6): 2983-2990. (1990). (PMID: 2188105).
    spacer

  144. Cuadrado, A.; Molloy, C.J.; Pech, M. "Expression of protein kinase CI in NIH 3T3 cells increases its growth response to specific activators.". FEBS Lett.. 260(2): 281-284. (1990). (PMID: 2298303).
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  145. Cuadrado, A.; Navarrete, M.H.; Canovas, J.L. "Cell size of proliferating plant cells increases with temperature: implications in the control of cell division.". Exp. Cell Res.. 185(1): 277-282. (1989). (PMID: 2806410).
    spacer

  146. Cuadrado, A.; Navarrete, M.H.; Canovas, J.L. "Exponential pattern of cell age distribution in dividing cells of plant meristems.". Cell Biol. Int. Rep.. 13(3): 283-289. (1989). (PMID: 2706689).
    spacer

  147. Navarrete, M.H.; Cuadrado, A.; Escalera, M.; Cánovas, J.L. "Regulation of G2 by cell size contributes to maintaining cell size variability within certain limits in higher plants.". J. Cell. Sci.. 87 ( Pt 5)(): 635-641. (1987). (PMID: 3667721).
    spacer

  148. Cuadrado, A.; Navarrete, M.H.; Cánovas, J.L. "The effect of partial protein synthesis inhibition on cell proliferation in higher plants.". J. Cell. Sci.. 76(): 97-9104. (1985). (PMID: 4066798).
    spacer

  149. Navarrete, M.H.; Cuadrado, A.; Cánovas, J.L. "Partial elimination of G1 and G2 periods in higher plant cells by increasing the S period.". Exp. Cell Res.. 148(2): 273-280. (1983). (PMID: 6628558).
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