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PUBLICACIONES

 

 

spacerTrabajos Publicados por Yolanda León Alvarez
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  1. de Lope, C.; García-Lucena, R.; Magariños, M.; León, Y.; Casa-Rodríguez, N.; Contreras, N.; Escudero-Iriarte, C.; Varela-Nieto, I.; Maire, P.; Palmero, I. "Dysfunction of programmed embryo senescence is linked to genetic developmental defects.". Development. (): . (2023). (PMID: 37017267).
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  2. León, Y.; Magariños, M.; Varela-Nieto, I. "Ceramide Kinase Inhibition Blocks IGF-1-Mediated Survival of Otic Neurosensory Progenitors by Impairing AKT Phosphorylation.". Front Cell Dev Biol. 9(): 678760. (2021). (PMID: 34179008).
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  3. Klionsky, D.J.; [ .., ].; Bartolome, A.; [ .., ].; Cuadrado, A.; [ .., ].; Escalante, R.; [ .., ].; García-Sanz, P.; [ .., ].; Lastres-Becker, I.; [ .., ].; León, Y.; [ .., ].; Martin-Sanz, P.; [ .., ].; Pajares, M.; [ .., ].; Rojo, A.I.; [ .., ].; Valverde, A.M.; [ .., ].; Varela-Nieto, I.; [ .., ].; Villalobo, A.; [ .., ].; Vincent, O.; [ .., ].; Tong, C.K. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).". Autophagy. (): 1-382. (2021). (PMID: 33634751).
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  4. Aburto, M.R.; Magariños, M.; Leon, Y.; Varela-Nieto, I.; Sanchez-Calderon, H. "AKT signaling mediates IGF-I survival actions on otic neural progenitors.". PLoS ONE. 7(1): e30790. (2012). (PMID: 22292041).
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  5. Rodríguez-de la Rosa, L.; Contreras-Rodríguez, J.; Cediel-Algovia, R.; León, Y.; Sánchez-Calderón, H.; Murillo-Cuesta, S.; Riquelme-Galiana, R.; de Diego-Sastre, J.I.; Prim-Espada, M.P.; Varela-Nieto, I.; , . "[Neurotrophic action of insulin-like growth factor-I in the inner ear].". Rev Neurol. 45(4): 245-250. (2008). (PMID: 17668408).
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  6. Sanchez-Calderon, H.; Milo, M.; Leon, Y.; Varela-Nieto, I. "A network of growth and transcription factors controls neuronal differentation and survival in the developing ear.". Int. J. Dev. Biol.. 51(6-7): 557-570. (2007). (PMID: 17891717).
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  7. Varela-Nieto, I.; Hartl, M.; Gorospe, I.; León, Y. "Anti-apoptotic actions of insulin-like growth factors: lessons from development and implications in neoplastic cell transformation.". Curr. Pharm. Des.. 13(7): 687-703. (2007). (PMID: 17346184).
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  8. Diaz-Casares, A.; Leon, Y.; de la Rosa, E.J.; Varela-Nieto, I. "Regulation of vertebrate sensory organ development: a scenario for growth hormone and insulin-like growth factors action.". Adv. Exp. Med. Biol.. 567(): 221-242. (2005). (PMID: 16370141).
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  9. Varela-Nieto, I.; Morales-Garcia, J.A.; Vigil, P.; Diaz-Casares, A.; Gorospe, I.; Sánchez-Galiano, S.; Cañon, S.; Camarero, G.; Contreras, J.; Cediel, R.; Leon, Y. "Trophic effects of insulin-like growth factor-I (IGF-I) in the inner ear.". Hear. Res.. 196(1-2): 19-25. (2004). (PMID: 15464297).
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  10. León, Y.; Sánchez-Galiano, S.; Gorospe, I. "Programmed cell death in the development of the vertebrate inner ear.". Apoptosis. 9(3): 255-264. (2004). (PMID: 15258457).
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  11. Camarero, G.; Leon, Y.; Gorospe, I.; De Pablo, F.; Alsina, B.; Giraldez, F.; Varela-Nieto, I. "Insulin-like growth factor 1 is required for survival of transit-amplifying neuroblasts and differentiation of otic neurons.". Dev. Biol.. 262(2): 242-253. (2003). (PMID: 14550788).
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  12. Varela-Nieto, I.; de la Rosa, E.J.; Valenciano, A.I.; León, Y. "Cell death in the nervous system: lessons from insulin and insulin-like growth factors.". Mol. Neurobiol.. 28(1): 23-50. (2003). (PMID: 14514984).
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  13. Frago, L.M.; Cañón, S.; de la Rosa, E.J.; León, Y.; Varela-Nieto, I. "Programmed cell death in the developing inner ear is balanced by nerve growth factor and insulin-like growth factor I.". J. Cell. Sci.. 116(Pt 3): 475-486. (2003). (PMID: 12508109).
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  14. Pañeda, C.; Villar, A.V.; Alonso, A.; Goñi, F.M.; Varela, F.; Brodbeck, U.; León, Y.; Varela-Nieto, I.; Jones, D.R. "Purification and characterization of insulin-mimetic inositol phosphoglycan-like molecules from grass pea (Lathyrus sativus) seeds.". Mol. Med.. 7(7): 454-460. (2001). (PMID: 11683370).
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  15. Frago, L.M.; Camerero, G.; Cañón, S.; Pañeda, C.; Sanz, C.; Leon, Y.; Giraldez, F.; Varela-Nieto, I. "Role of diffusible and transcription factors in inner ear development: implications in regeneration.". Histol. Histopathol.. 15(2): 657-666. (2000). (PMID: 10809387).
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  16. Sanz, C.; León, Y.; Cañón, S.; Alvarez, L.; Giraldez, F.; Varela-Nieto, I. "Pattern of expression of the jun family of transcription factors during the early development of the inner ear: implications in apoptosis.". J. Cell. Sci.. 112 ( Pt 22)(): 3967-3974. (1999). (PMID: 10547357).
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  17. León, Y.; Sanz, C.; Frago, L.M.; Camarero, G.; Cañón, S.; Varela-Nieto, I.; Giráldez, F. "Involvement of insulin-like growth factor-I in inner ear organogenesis and regeneration.". Horm. Metab. Res.. 31(2-3): 126-132. (1999). (PMID: 10226792).
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  18. Sanz, C.; León, Y.; Troppmair, J.; Rapp, U.R.; Varela-Nieto, I. "Strict regulation of c-Raf kinase levels is required for early organogenesis of the vertebrate inner ear.". Oncogene. 18(2): 429-437. (1999). (PMID: 9927199).
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  19. León, Y.; Sanz, C.; Giráldez, F.; Varela-Nieto, I. "Induction of cell growth by insulin and insulin-like growth factor-I is associated with Jun expression in the otic vesicle.". J. Comp. Neurol.. 398(3): 323-332. (1998). (PMID: 9714146).
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  20. Villar, A.V.; Goñi, F.M.; Alonso, A.; Jones, D.R.; León, Y.; Varela-Nieto, I. "Phospholipase cleavage of glycosylphosphatidylinositol reconstituted in liposomal membranes.". FEBS Lett.. 432(3): 150-154. (1998). (PMID: 9720914).
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  21. Frago, L.M.; León, Y.; de la Rosa, E.J.; Gómez-Muñoz, A.; Varela-Nieto, I. "Nerve growth factor and ceramides modulate cell death in the early developing inner ear.". J. Cell. Sci.. 111 ( Pt 5)(): 549-556. (1998). (PMID: 9454729).
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  22. Caro, H.N.; Kunjara, S.; Rademacher, T.W.; León, Y.; Jones, D.R.; Avila, M.A.; Varela-Nieto, I. "Isolation and partial characterisation of insulin-mimetic inositol phosphoglycans from human liver.". Biochem. Mol. Med.. 61(2): 214-228. (1997). (PMID: 9259987).
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  23. Leon, Y.; Varela-Nieto, I.; Breen, K.C. "Neural cell adhesion molecule expression in the developing chick otic vesicle.". Biochem. Soc. Trans.. 25(1): 10S. (1997). (PMID: 9056908).
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  24. Sanz, C.; Leon, Y.; Garcia-Gil, M.; Varela-Nieto, I. "Role of Raf kinases during inner ear development.". Int. J. Dev. Biol.. Suppl 1(): 83S-84S. (1996). (PMID: 9087707).
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  25. Varela-Nieto, I.; León, Y.; Caro, H.N. "Cell signalling by inositol phosphoglycans from different species.". Comp. Biochem. Physiol. B, Biochem. Mol. Biol.. 115(2): 223-241. (1996). (PMID: 8939003).
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  26. León, Y.; Vazquez, E.; Sanz, C.; Vega, J.A.; Mato, J.M.; Giraldez, F.; Represa, J.; Varela-Nieto, I. "Insulin-like growth factor-I regulates cell proliferation in the developing inner ear, activating glycosyl-phosphatidylinositol hydrolysis and Fos expression.". Endocrinology. 136(8): 3494-3503. (1995). (PMID: 7628386).
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  27. Leon, Y.; Sanz, C.; Varela-Nieto, I. "Intracellular mediators of insulin-like growth factor I during otic vesicle development.". Biochem. Soc. Trans.. 23(2): 185S. (1995). (PMID: 7672208).
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  28. León, Y.; Sanchez, J.A.; Miner, C.; Ariza-McNaughton, L.; Represa, J.J.; Giraldez, F. "Developmental regulation of Fos-protein during proliferative growth of the otic vesicle and its relation to differentiation induced by retinoic acid.". Dev. Biol.. 167(1): 75-86. (1995). (PMID: 7851664).
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  29. Zapata, A.; León, Y.; Mato, J.M.; Varela-Nieto, I.; Penadés, S.; Martín-Lomas, M. "Synthesis and investigation of the possible insulin-like activity of 1D-4-O- and 1D-6-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-myo-inositol 1-phosphate and 1D-6-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-myo-inositol 1,2-(cyclic phosphate).". Carbohydr. Res.. 264(1): 21-31. (1994). (PMID: 8001018).
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Instituto de Investigaciones Biomédicas "Alberto Sols"
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