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spacerTrabajos Publicados por José M. Mato de la Paz
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  1. Avila, M.A.; Carretero, M.V.; Rodriguez, E.N.; Mato, J.M. "Regulation by hypoxia of methionine adenosyltransferase activity and gene expression in rat hepatocytes.". Gastroenterology. 114(2): 364-371. (1998). (PMID: 9453498).
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  2. Sánchez-Góngora, E.; Ruiz, F.; Mingorance, J.; An, W.; Corrales, F.J.; Mato, J.M. "Interaction of liver methionine adenosyltransferase with hydroxyl radical.". FASEB J.. 11(12): 1013-1019. (1997). (PMID: 9337154).
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  3. Alvarez, L.; Sánchez-Góngora, E.; Mingorance, J.; Pajares, M.A.; Mato, J.M. "Characterization of rat liver-specific methionine adenosyltransferase gene promoter. Role of distal upstream cis-acting elements in the regulation of the transcriptional activity.". J. Biol. Chem.. 272(36): 22875-22883. (1997). (PMID: 9278450).
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  4. Mato, J.M.; Alvarez, L.; Ortiz, P.; Pajares, M.A. "S-adenosylmethionine synthesis: molecular mechanisms and clinical implications.". Pharmacol. Ther.. 73(3): 265-280. (1997). (PMID: 9175157).
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  5. Gil, B.; Pajares, M.A.; Mato, J.M.; Alvarez, L. "Glucocorticoid regulation of hepatic S-adenosylmethionine synthetase gene expression.". Endocrinology. 138(3): 1251-1258. (1997). (PMID: 9048633).
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  6. Mingorance, J.; Alvarez, L.; Pajares, M.A.; Mato, J.M. "Recombinant rat liver S-adenosyl-L-methionine synthetase tetramers and dimers are in equilibrium.". Int. J. Biochem. Cell Biol.. 29(3): 485-491. (1997). (PMID: 9202427).
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  7. Kotb, M.; Mudd, S.H.; Mato, J.M.; Geller, A.M.; Kredich, N.M.; Chou, J.Y.; Cantoni, G.L. "Consensus nomenclature for the mammalian methionine adenosyltransferase genes and gene products.". Trends Genet.. 13(2): 51-52. (1997). (PMID: 9055605).
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  8. Sanchez-Bueno, A.; Greenwood, M.R.; Varela-Nieto, I.; Marrero, I.; Gil, B.; Mato, J.M.; Cobbold, P.H. "Inositol-phosphoglycan inhibits calcium oscillations in hepatocytes by reducing calcium entry.". Cell Calcium. 21(2): 125-133. (1997). (PMID: 9132295).
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  9. Avila, M.A.; Mingorance, J.; Martínez-Chantar, M.L.; Casado, M.; Martin-Sanz, P.; Boscá, L.; Mato, J.M. "Regulation of rat liver S-adenosylmethionine synthetase during septic shock: role of nitric oxide.". Hepatology. 25(2): 391-396. (1997). (PMID: 9021952).
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  10. Sánchez-Góngora, E.; Pastorino, J.G.; Alvarez, L.; Pajares, M.A.; García, C.; Viña, J.R.; Mato, J.M.; Farber, J.L. "Increased sensitivity to oxidative injury in chinese hamster ovary cells stably transfected with rat liver S-adenosylmethionine synthetase cDNA.". Biochem. J.. 319 ( Pt 3)(): 767-773. (1996). (PMID: 8920979).
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  11. Gil, B.; Casado, M.; Pajares, M.A.; Boscá, L.; Mato, J.M.; Martín-Sanz, P.; Alvarez, L. "Differential expression pattern of S-adenosylmethionine synthetase isoenzymes during rat liver development.". Hepatology. 24(4): 876-881. (1996). (PMID: 8855191).
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  12. Gassó, M.; Rubio, M.; Varela, G.; Cabré, M.; Caballería, J.; Alonso, E.; Deulofem, R.; Camps, J.; Giménez, A.; Pajares, M.; Parés, A.; Mato, J.M.; Rodés, J. "Effects of S-adenosylmethionine on lipid peroxidation and liver fibrogenesis in carbon tetrachloride-induced cirrhosis.". J. Hepatol.. 25(2): 200-205. (1996). (PMID: 8878782).
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  13. Mingorance, J.; Alvarez, L.; Sánchez-Góngora, E.; Mato, J.M.; Pajares, M.A. "Site-directed mutagenesis of rat liver S-adenosylmethionine synthetase. Identification of a cysteine residue critical for the oligomeric state.". Biochem. J.. 315 ( Pt 3)(): 761-766. (1996). (PMID: 8645155).
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  14. León, Y.; Vazquez, E.; Sanz, C.; Vega, J.A.; Mato, J.M.; Giraldez, F.; Represa, J.; Varela-Nieto, I. "Insulin-like growth factor-I regulates cell proliferation in the developing inner ear, activating glycosyl-phosphatidylinositol hydrolysis and Fos expression.". Endocrinology. 136(8): 3494-3503. (1995). (PMID: 7628386).
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  15. Deigner, H.P.; Mato, J.M.; Pajares, M.A. "Study of the rat liver S-adenosylmethionine synthetase active site with 8-azido ATP.". Biochem. J.. 308 ( Pt 2)(): 565-571. (1995). (PMID: 7772043).
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  16. Clemente, R.; Jones, D.R.; Ochoa, P.; Romero, G.; Mato, J.M.; Varela-Nieto, I. "Role of glycosyl-phosphatidylinositol hydrolysis as a mitogenic signal for epidermal growth factor.". Cell. Signal.. 7(4): 411-421. (1995). (PMID: 8527310).
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  17. Mato, J.M.; Alvarez, L.; Ortiz, P.; Mingorance, J.; Durán, C.; Pajares, M.A. "S-adenosyl-L-methionine synthetase and methionine metabolism deficiencies in cirrhosis.". Adv. Exp. Med. Biol.. 368(): 113-117. (1994). (PMID: 7741002).
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  18. Pajares, M.A.; Durán, C.; Corrales, F.; Mato, J.M. "Protein kinase C phosphorylation of rat liver S-adenosylmethionine synthetase: dissociation and production of an active monomer.". Biochem. J.. 303 ( Pt 3)(): 949-955. (1994). (PMID: 7980467).
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  19. Zapata, A.; León, Y.; Mato, J.M.; Varela-Nieto, I.; Penadés, S.; Martín-Lomas, M. "Synthesis and investigation of the possible insulin-like activity of 1D-4-O- and 1D-6-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-myo-inositol 1-phosphate and 1D-6-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-myo-inositol 1,2-(cyclic phosphate).". Carbohydr. Res.. 264(1): 21-31. (1994). (PMID: 8001018).
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  20. Alvarez, L.; Mingorance, J.; Pajares, M.A.; Mato, J.M. "Expression of rat liver S-adenosylmethionine synthetase in Escherichia coli results in two active oligomeric forms.". Biochem. J.. 301 ( Pt 2)(): 557-561. (1994). (PMID: 8043003).
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  21. Sánchez-Gutiérrez, J.C.; Sánchez-Arias, J.A.; Valle, J.C.; Guadaño, A.; Samper, B.; Mato, J.M.; Felíu, J.E. "Insulin resistance in genetically obese (fa/fa) rats: changes in the glycosyl-phosphatidylinositol signaling system in isolated hepatocytes.". Endocrinology. 134(3): 1485-1492. (1994). (PMID: 8119190).
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  22. Represa, J.; Avila, M.A.; Romero, G.; Mato, J.M.; Giraldez, F.; Varela-Nieto, I. "Brain-derived neurotrophic factor and neurotrophin-3 induce cell proliferation in the cochleovestibular ganglion through a glycosyl-phosphatidylinositol signaling system.". Dev. Biol.. 159(1): 257-265. (1993). (PMID: 8365564).
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  23. Avila, M.A.; Varela-Nieto, I.; Romero, G.; Mato, J.M.; Giraldez, F.; Van De Water, T.R.; Represa, J. "Brain-derived neurotrophic factor and neurotrophin-3 support the survival and neuritogenesis response of developing cochleovestibular ganglion neurons.". Dev. Biol.. 159(1): 266-275. (1993). (PMID: 8365565).
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  24. Sanchez-Arias, J.A.; Sanchez-Gutierrez, J.C.; Guadaño, A.; Alvarez, J.F.; Samper, B.; Mato, J.M.; Feliu, J.E. "Impairment of glycosyl-phosphatidylinositol-dependent insulin signaling system in isolated rat hepatocytes by streptozotocin-induced diabetes.". Endocrinology. 131(4): 1727-1733. (1992). (PMID: 1396318).
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  25. Corrales, F.; Giménez, A.; Alvarez, L.; Caballería, J.; Pajares, M.A.; Andreu, H.; Parés, A.; Mato, J.M.; Rodés, J. "S-adenosylmethionine treatment prevents carbon tetrachloride-induced S-adenosylmethionine synthetase inactivation and attenuates liver injury.". Hepatology. 16(4): 1022-1027. (1992). (PMID: 1398482).
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  26. Pajares, M.A.; Durán, C.; Corrales, F.; Pliego, M.M.; Mato, J.M. "Modulation of rat liver S-adenosylmethionine synthetase activity by glutathione.". J. Biol. Chem.. 267(25): 17598-17605. (1992). (PMID: 1517209).
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  27. Pajares, M.A.; Corrales, F.; Durán, C.; Mato, J.M.; Alvarez, L. "How is rat liver S-adenosylmethionine synthetase regulated?". FEBS Lett.. 309(1): 1-4. (1992). (PMID: 1511738).
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  28. Alvarez, L.; Asunción, M.; Corrales, F.; Pajares, M.A.; Mato, J.M. "Analysis of the 5' non-coding region of rat liver S-adenosylmethionine synthetase mRNA and comparison of the Mr deduced from the cDNA sequence and the purified enzyme.". FEBS Lett.. 290(1-2): 142-146. (1991). (PMID: 1915866).
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  29. Represa, J.; Avila, M.A.; Miner, C.; Giraldez, F.; Romero, G.; Clemente, R.; Mato, J.M.; Varela-Nieto, I. "Glycosyl-phosphatidylinositol/inositol phosphoglycan: a signaling system for the low-affinity nerve growth factor receptor.". Proc. Natl. Acad. Sci. U.S.A.. 88(18): 8016-8019. (1991). (PMID: 1654553).
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  30. Corrales, F.; Ochoa, P.; Rivas, C.; Martin-Lomas, M.; Mato, J.M.; Pajares, M.A. "Inhibition of glutathione synthesis in the liver leads to S-adenosyl-L-methionine synthetase reduction.". Hepatology. 14(3): 528-533. (1991). (PMID: 1874498).
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  31. Alvarez, L.; Avila, M.A.; Mato, J.M.; Castaño, J.G.; Varela-Nieto, I. "Insulin-like effects of inositol phosphate-glycan on messenger RNA expression in rat hepatocytes.". Mol. Endocrinol.. 5(8): 1062-1068. (1991). (PMID: 1719385).
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  32. Varela-Nieto, I.; Represa, J.; Avila, M.A.; Miner, C.; Mato, J.M.; Giraldez, F. "Inositol phospho-oligosaccharide stimulates cell proliferation in the early developing inner ear.". Dev. Biol.. 143(2): 432-435. (1991). (PMID: 1991566).
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  33. Pajares, M.A.; Corrales, F.J.; Ochoa, P.; Mato, J.M. "The role of cysteine-150 in the structure and activity of rat liver S-adenosyl-L-methionine synthetase.". Biochem. J.. 274 ( Pt 1)(): 225-229. (1991). (PMID: 2001237).
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  34. Mato, J.M.; Corrales, F.; Martin-Duce, A.; Ortiz, P.; Pajares, M.A.; Cabrero, C. "Mechanisms and consequences of the impaired trans-sulphuration pathway in liver disease: Part I. Biochemical implications.". Drugs. 40 Suppl 3(): 58-64. (1990). (PMID: 2081481).
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  35. Puerta, J.; Mato, J.M.; Alemany, S. "Phospho-oligosaccharide dependent phosphorylation of ATP citrate lyase.". Adv. Enzyme Regul.. 30(): 109-117. (1990). (PMID: 2119547).
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  36. Alemany, S.; Puerta, J.; Guadaño, A.; Mato, J.M. "Modulation of casein kinase II activity by the polar head group of an insulin-sensitive glycosyl-phosphatidylinositol.". J. Biol. Chem.. 265(9): 4849-4852. (1990). (PMID: 2138621).
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  37. Corrales, F.; Cabrero, C.; Pajares, M.A.; Ortiz, P.; Martin-Duce, A.; Mato, J.M. "Inactivation and dissociation of S-adenosylmethionine synthetase by modification of sulfhydryl groups and its possible occurrence in cirrhosis.". Hepatology. 11(2): 216-222. (1990). (PMID: 2307400).
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  38. Cabrero, C.; Duce, A.M.; Ortiz, P.; Alemany, S.; Mato, J.M. "Specific loss of the high-molecular-weight form of S-adenosyl-L-methionine synthetase in human liver cirrhosis.". Hepatology. 8(6): 1530-1534. (1988). (PMID: 3192166).
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  39. Alemany, S.; Mato, J.M.; Strålfors, P. "Phospho-dephospho-control by insulin is mimicked by a phospho-oligosaccharide in adipocytes.". Nature. 330(6143): 77-79. (1987). (PMID: 3313056).
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  40. Villalba, M.; Pajares, M.A.; Renart, M.F.; Mato, J.M. "Protein kinase C catalyses the phosphorylation and activation of rat liver phospholipid methyltransferase.". Biochem. J.. 241(3): 911-916. (1987). (PMID: 3593229).
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  41. Pajares, M.A.; Villalba, M.; Mato, J.M. "Purification of phospholipid methyltransferase from rat liver microsomal fraction.". Biochem. J.. 237(3): 699-705. (1986). (PMID: 3800912).
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  42. Villalba, M.; Varela, I.; Mérida, I.; Pajares, M.A.; Martínez del Pozo, A.; Mato, J.M. "Modulation by the ratio S-adenosylmethionine/S-adenosylhomocysteine of cyclic AMP-dependent phosphorylation of the 50 kDa protein of rat liver phospholipid methyltransferase.". Biochim. Biophys. Acta. 847(3): 273-279. (1985). (PMID: 2998482).
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  43. Pajares, M.A.; Alemany, S.; Varela, I.; Marin Cao, D.; Mato, J.M. "Purification and photoaffinity labelling of lipid methyltransferase from rat liver.". Biochem. J.. 223(1): 61-66. (1984). (PMID: 6497846).
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  44. Varela, I.; Mérida, I.; Pajares, M.; Villalba, M.; Mato, J.M. "Activation of partially purified rat liver lipid methyltransferase by phosphorylation.". Biochem. Biophys. Res. Commun.. 122(3): 1065-1070. (1984). (PMID: 6332623).
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  45. Gil, M.G.; van Lookeren Campagne, M.W.; Alemany, S.; Municio, A.M.; Mato, J.M. "Effect of fatty acid anilides on the generation of arachidonic acid by human polymorphonuclear leukocytes.". FEBS Lett.. 162(1): 151-155. (1983). (PMID: 6413256).
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  46. Mato, J.M.; Alvarez Chiva, V.; Marín Cao, D.; Varela, I.; García Gil, M.; Alemany, S. "[Hormonal regulation of the synthesis of phosphatidylcholine by transmethylation].". Rev Clin Esp. 171(1): 7-10. (1983). (PMID: 6658087).
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  47. Mato, J.M.; Alemany, S. "What is the function of phospholipid N-methylation?". Biochem. J.. 213(1): 1-10. (1983). (PMID: 6311156).
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  48. Alemany, S.; Varela, I.; Mato, J.M. "Inhibition of phosphatidylcholine synthesis by vasopressin and angiotensin in rat hepatocytes.". Biochem. J.. 208(2): 453-457. (1982). (PMID: 6818955).
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  49. Alemany, S.; Varela, I.; Harper, J.F.; Mato, J.M. "Calmodulin regulation of phospholipid and fatty acid methylation by rat liver microsomes.". J. Biol. Chem.. 257(16): 9249-9251. (1982). (PMID: 6809733).
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  50. Alemany, S.; Varela, I.; Mato, J.M. "Stimulation by vasopressin and angiotensin of phospholipid methyltransferase in isolated rat hepatocytes.". FEBS Lett.. 135(1): 111-114. (1981). (PMID: 6797839).
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  51. Alemany, S.; García Gil, M.; Mato, J.M. "Regulation by guanosine 3':5'-cyclic monophosphate of phospholipid methylation during chemotaxis in Dictyostelium discoideum.". Proc. Natl. Acad. Sci. U.S.A.. 77(12): 6996-6999. (1980). (PMID: 6261233).
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  52. Castaño, J.G.; Alemany, S.; Nieto, A.; Mato, J.M. "Activation of phospholipid methyltransferase by glucagon in rat hepatocytes.". J. Biol. Chem.. 255(19): 9041-9043. (1980). (PMID: 6251072).
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  53. Gil, M.G.; Alemany, S.; Cao, D.M.; Castano, J.G.; Mato, J.M. "Calmodulin modulates phospholipid methylation in Dictyostelium discoideum.". Biochem. Biophys. Res. Commun.. 94(4): 1325-1330. (1980). (PMID: 6772186).
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