INVESTIGACIÓN

 
  • Grupos de Investigación
  • Unidades de Investigación
  • Memoria Cientifíca
  • Publicaciones
espacio

 

PUBLICACIONES

 

 

spacerTrabajos Publicados por Susana Alemany de la Peña
spacer
  1. Vladimir de la Rosa, J.; Tabraue, C.; Huang, Z.; Orizaola, M.C.; Martin-Rodríguez, P.; Steffensen, K.R.; Zapata, J.M.; Boscá, L.; Tontonoz, P.; Alemany, S.; Treuter, E.; Castrillo, A. "Reprogramming of the LXRα Transcriptome Sustains Macrophage Secondary Inflammatory Responses.". Adv Sci (Weinh). (): e2307201. (2024). (PMID: 38549193).
    spacer

  2. Contreras-Jurado, C.; Montero-Pedrazuela, A.; Pérez, R.F.; Alemany, S.; Fraga, M.F.; Aranda, A. "The thyroid hormone enhances mouse embryonic fibroblasts reprogramming to pluripotent stem cells: role of the nuclear receptor corepressor 1.". Front Endocrinol (Lausanne). 14(): 1235614. (2023). (PMID: 38107517).
    spacer

  3. Gutierrez, A.H.; Mazariegos, M.S.; Alemany, S.; Nevzorova, Y.A.; Cubero, F.J.; Sanz-García, C. "Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease.". Biochim Biophys Acta Mol Basis Dis. 1869(4): 166660. (2023). (PMID: 36764206).
    spacer

  4. Amich, I.; Anguita, E.; Escribano-Serrat, S.; Alvarez, C.; Rodríguez-Muñoz, D.; García, V.; Bello, R.; Peña-Pedrosa, J.A.; Martínez-Micaelo, N.; Amigó, N.; Ortiz, P.; Torrejón, M.J.; Boscá, L.; Martín-Sánchez, J.; Aranda, A.; Alemany, S. "Free triiodothyronine levels and age influences the metabolic profile and COVID-19 severity parameters in euthyroid and levothyroxine-treated patients.". Front Endocrinol (Lausanne). 13(): 1025032. (2022). (PMID: 36440226).
    spacer

  5. López-Mateo, I.; Rodríguez-Muñoz, D.; de La Rosa, J.V.; Castrillo, A.; Alemany, S.; Aranda, A. "Regulation of metabolic and transcriptional responses by the thyroid hormone in cellular models of murine macrophages.". Front Immunol. 13(): 923727. (2022). (PMID: 35935955).
    spacer

  6. Rodriguez-Muñoz, D.; Sánchez, Á.; Pérez-Benavente, S.; Contreras-Jurado, C.; Montero-Pedrazuela, A.; Toledo-Castillo, M.; Gutiérrez-Hernández, M.; Rodrigues-Díez, R.; Folgueira, C.; Briones, A.M.; Sabio, G.; Monedero-Cobeta, I.; Chávez-Coira, I.; Castejón, D.; Fernández-Valle, E.; Regadera, J.; Bautista, J.M.; Aranda, A.; Alemany, S. "Hypothyroidism confers tolerance to cerebral malaria.". Sci Adv. 8(14): eabj7110. (2022). (PMID: 35385300).
    spacer

  7. Sánchez, Á.; Orizaola, M.C.; Rodríguez-Muñoz, D.; Aranda, A.; Castrillo, A.; Alemany, S. "Stress erythropoiesis in atherogenic mice.". Sci Rep. 10(1): 18469. (2020). (PMID: 33116141).
    spacer

  8. Sánchez, Á.; Anguita, E.; Chaparro, A.; Roldán-Etcheverry, J.J.; López-García, A.; Ramos-Acosta, C.; Oancea, R.; Rodriguez-Muñoz, D.; Alemany, S. "Abnormal Dendritic Cell-poiesis in Patients With Lower-risk Myelodysplastic Syndromes.". Hemasphere. 4(1): e335. (2020). (PMID: 32072149).
    spacer

  9. Sánchez, Á.; Contreras-Jurado, C.; Rodríguez, D.; Regadera, J.; Alemany, S.; Aranda, A. "Hematopoiesis in aged female mice devoid of thyroid hormone receptors.". J. Endocrinol.. 244(1): 83-94. (2020). (PMID: 31585438).
    spacer

  10. López-Mateo, I.; Alonso-Merino, E.; Suárez-Cabrera, C.; Park, J.W.; Cheng, S.Y.; Alemany, S.; Paramio, J.M.; Aranda, A. "The thyroid hormone receptor β inhibits self-renewal capacity of breast cancer stem cells.". Thyroid. (): . (2019). (PMID: 31760908).
    spacer

  11. Ramón-Vázquez, A.; de la Rosa, J.V.; Tabraue, C.; Lopez, F.; Díaz-Chico, B.N.; Bosca, L.; Tontonoz, P.; Alemany, S.; Castrillo, A. "Common and Differential Transcriptional Actions of Nuclear Receptors LXRα and LXRβ in macrophages.". Mol. Cell. Biol.. (): . (2019). (PMID: 30602495).
    spacer

  12. Sánchez, Á.; Mengíbar, M.; Fernández, M.; Alemany, S.; Heras, A.; Acosta, N. "Influence of Preparation Methods of Chitooligosaccharides on Their Physicochemical Properties and Their Anti-Inflammatory Effects in Mice and in RAW264.7 Macrophages.". Mar Drugs. 16(11): . (2018). (PMID: 30400250).
    spacer

  13. Alsina-Beauchamp, D.; Escós, A.; Fajardo, P.; González-Romero, D.; Díaz-Mora, E.; Risco, A.; Martín-Serrano, M.A.; Del Fresno, C.; Dominguez-Andrés, J.; Aparicio, N.; Zur, R.; Shpiro, N.; Brown, G.D.; Ardavín, C.; Netea, M.G.; Alemany, S.; Sanz-Ezquerro, J.J.; Cuenda, A. "Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity.". EMBO Mol Med. 10(5): . (2018). (PMID: 29661910).
    spacer

  14. Rada, P.; Pardo, V.; Mobasher, M.; Garcia, I.; Ruiz, L.; Gonzalez Rodriguez, A.; Sánchez Ramos, C.; Muntané, J.; Alemany, S.; James, L.P.; Simpson, K.J.; Monsalve, M.; Valdecantos, M.P.; Valverde, A. "SIRT1 CONTROLS ACETAMINOPHEN HEPATOTOXICITY BY MODULATING INFLAMMATION AND OXIDATIVE STRESS.". Antioxid. Redox Signal.. (): . (2017). (PMID: 29084443).
    spacer

  15. Sánchez, Á.; Relaño, C.; Carrasco, A.; Contreras-Jurado, C.; Martín-Duce, A.; Aranda, A.; Alemany, S. "Map3k8 controls granulocyte colony-stimulating factor production and neutrophil precursor proliferation in lipopolysaccharide-induced emergency granulopoiesis.". Sci Rep. 7(1): 5010. (2017). (PMID: 28694430).
    spacer

  16. Sanz-Garcia, C.; Sánchez, Á.; Contreras-Jurado, C.; Cales, C.; Barranquero, C.; Muñoz, M.; Merino, R.; Escudero, P.; Sanz, M.J.; Osada, J.; Aranda, A.; Alemany, S. "Map3k8 Modulates Monocyte State and Atherogenesis in ApoE-/- Mice.". Arterioscler. Thromb. Vasc. Biol.. 37(2): 237-246. (2017). (PMID: 27856455).
    spacer

  17. Contreras-Jurado, C.; Alonso-Merino, E.; Saiz-Ladera, C.; Valiño, A.J.; Regadera, J.; Alemany, S.; Aranda, A. "The Thyroid Hormone Receptors Inhibit Hepatic Interleukin-6 Signaling During Endotoxemia.". Sci Rep. 6(): 30990. (2016). (PMID: 27484112).
    spacer

  18. Boscá, L.; González-Ramos, S.; Prieto, P.; Fernández-Velasco, M.; Mojena, M.; Martín-Sanz, P.; Alemany, S. "Metabolic signatures linked to macrophage polarization: from glucose metabolism to oxidative phosphorylation.". Biochem. Soc. Trans.. 43(4): 740-744. (2015). (PMID: 26551722).
    spacer

  19. Berthou, F.; Ceppo, F.; Dumas, K.; Massa, F.; Vergoni, B.; Alemany, S.; Cormont, M.; Tanti, J.F. "The Tpl2 Kinase Regulates the COX-2/Prostaglandin E2 Axis in Adipocytes in Inflammatory Conditions.". Mol. Endocrinol.. 29(7): 1025-1036. (2015). (PMID: 26020725).
    spacer

  20. Sanz-Garcia, C.; Nagy, L.E.; Lasunción, M.A.; Fernandez, M.; Alemany, S. "Cot/tpl2 participates in the activation of macrophages by adiponectin.". J. Leukoc. Biol.. 95(6): 917-930. (2014). (PMID: 24532642).
    spacer

  21. Sanz-Garcia, C.; Ferrer-Mayorga, G.; González-Rodríguez, Á.; Valverde, A.M.; Martín-Duce, A.; Velasco-Martín, J.P.; Regadera, J.; Fernández, M.; Alemany, S. "Sterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2.". J. Biol. Chem.. 288(21): 15342-15351. (2013). (PMID: 23572518).
    spacer

  22. López-Pelaéz, M.; Fumagalli, S.; Sanz, C.; Herrero, C.; Guerra, S.; Fernandez, M.; Alemany, S. "Cot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like receptor-activated macrophages.". Mol. Biol. Cell. 23(15): 2982-2992. (2012). (PMID: 22675026).
    spacer

  23. Fernández, M.; Manso, R.; Bernaldo de Quirós, F.; Bernáldez, F.; López, P.; Martín-Duce, A.; Alemany, S. "Involvement of Cot activity in the proliferation of ALCL lymphoma cells.". Biochem. Biophys. Res. Commun.. 411(4): 655-660. (2011). (PMID: 21741362).
    spacer

  24. López-Peláez, M.; Soria-Castro, I.; Boscá, L.; Fernández, M.; Alemany, S. "Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression.". Eur. J. Immunol.. 41(6): 1733-1741. (2011). (PMID: 21469113).
    spacer

  25. Soria-Castro, I.; Krzyzanowska, A.; Pelaéz, M.L.; Regadera, J.; Ferrer, G.; Montoliu, L.; Rodríguez-Ramos, R.; Fernández, M.; Alemany, S. "Cot/tpl2 (MAP3K8) mediates myeloperoxidase activity and hypernociception following peripheral inflammation.". J. Biol. Chem.. 285(44): 33805-33815. (2010). (PMID: 20736176).
    spacer

  26. Rodríguez, C.; López, P.; Pozo, M.; Duce, A.M.; López-Pelaéz, M.; Fernández, M.; Alemany, S. "COX2 expression and Erk1/Erk2 activity mediate Cot-induced cell migration.". Cell. Signal.. 20(9): 1625-1631. (2008). (PMID: 18572386).
    spacer

  27. Rodríguez, C.; Pozo, M.; Nieto, E.; Fernández, M.; Alemany, S. "TRAF6 and Src kinase activity regulates Cot activation by IL-1.". Cell. Signal.. 18(9): 1376-1385. (2006). (PMID: 16371247).
    spacer

  28. Pérez de Diego, R.; López-Granados, E.; Pozo, M.; Rodríguez, C.; Sabina, P.; Ferreira, A.; Fontan, G.; García-Rodríguez, M.C.; Alemany, S. "Bruton's tyrosine kinase is not essential for LPS-induced activation of human monocytes.". J. Allergy Clin. Immunol.. 117(6): 1462-1469. (2006). (PMID: 16751014).
    spacer

  29. Caivano, M.; Rodriguez, C.; Cohen, P.; Alemany, S. "15-Deoxy-Delta12,14-prostaglandin J2 regulates endogenous Cot MAPK kinase kinase 1 activity induced by lipopolysaccharide.". J. Biol. Chem.. 278(52): 52124-52130. (2003). (PMID: 14557273).
    spacer

  30. Gándara, M.L.; López, P.; Hernando, R.; Castaño, J.G.; Alemany, S. "The COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activity.". Mol. Cell. Biol.. 23(20): 7377-7390. (2003). (PMID: 14517305).
    spacer

  31. de Gregorio, R.; Iñiguez, M.A.; Fresno, M.; Alemany, S. "Cot kinase induces cyclooxygenase-2 expression in T cells through activation of the nuclear factor of activated T cells.". J. Biol. Chem.. 276(29): 27003-27009. (2001). (PMID: 11356833).
    spacer

  32. Velasco-Sampayo, A.; Alemany, S. "p27kip protein levels and E2F activity are targets of Cot kinase during G1 phase progression in T cells.". J. Immunol.. 166(10): 6084-6090. (2001). (PMID: 11342626).
    spacer

  33. Sánchez-Góngora, E.; Lisbona, C.; de Gregorio, R.; Ballester, A.; Calvo, V.; Pérez-Jurado, L.; Alemany, S. "COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activation.". J. Biol. Chem.. 275(40): 31379-31386. (2000). (PMID: 10896655).
    spacer

  34. Campos, C.; de Gregorio, R.; García-Nieto, R.; Gago, F.; Ortiz, P.; Alemany, S. "Regulation of cyclooxygenase activity by metamizol.". Eur. J. Pharmacol.. 378(3): 339-347. (1999). (PMID: 10493111).
    spacer

  35. Ballester, A.; Velasco, A.; Tobeña, R.; Alemany, S. "Cot kinase activates tumor necrosis factor-alpha gene expression in a cyclosporin A-resistant manner.". J. Biol. Chem.. 273(23): 14099-14106. (1998). (PMID: 9603908).
    spacer

  36. Lisbona, C.; Alemany, S.; Fernández-Renart, M. "Regulation of ERK2 dephosphorylation in G1-stimulated rat T lymphoblasts.". J. Clin. Immunol.. 17(6): 494-501. (1997). (PMID: 9418190).
    spacer

  37. Ballester, A.; Tobeña, R.; Lisbona, C.; Calvo, V.; Alemany, S. "Cot kinase regulation of IL-2 production in Jurkat T cells.". J. Immunol.. 159(4): 1613-1618. (1997). (PMID: 9257820).
    spacer

  38. Tobeña, R.; Horikawa, S.; Calvo, V.; Alemany, S. "Interleukin-2 induces gamma-S-adenosyl-L-methionine synthetase gene expression during T-lymphocyte activation.". Biochem. J.. 319 ( Pt 3)(): 929-933. (1996). (PMID: 8921001).
    spacer

  39. Carrera, A.C.; Calvo, V.; Borlado, L.R.; Paradis, H.; Alemany, S.; Roberts, T.M.; Martinez-A, C. "The catalytic domain of pp56(lck), but not its regulatory domain, is sufficient for inducing IL-2 production.". J. Immunol.. 157(9): 3775-3782. (1996). (PMID: 8892605).
    spacer

  40. Lisbona, C.; Alemany, S.; Calvo, V.; Fernandez-Renart, M. "Raf-1 and ERK2 kinases are required for phorbol 12,13-dibutyrate-stimulated proliferation of rat lymphoblasts. ERK2 activation precedes Raf-1 hyperphosphorylation.". Eur. J. Immunol.. 24(11): 2746-2754. (1994). (PMID: 7957567).
    spacer

  41. Garcia, I.; Pipaon, C.; Alemany, S.; Perez-Castillo, A. "Induction of NGFI-B gene expression during T cell activation. Role of protein phosphatases.". J. Immunol.. 153(8): 3417-3425. (1994). (PMID: 7930567).
    spacer

  42. Perez-Castillo, A.; Pipaón, C.; García, I.; Alemany, S. "NGFI-A gene expression is necessary for T lymphocyte proliferation.". J. Biol. Chem.. 268(26): 19445-19450. (1993). (PMID: 8366092).
    spacer

  43. Garcia, I.; Perez-Castillo, A.; Moreno, J.; Alemany, S. "Beta-endorphin inhibits interleukin-2 release and expression of interleukin-2 receptors in concanavalin A-stimulated splenic lymphocytes.". Lymphokine Cytokine Res.. 11(6): 339-345. (1992). (PMID: 1477186).
    spacer

  44. Puerta, J.; Mato, J.M.; Alemany, S. "Phospho-oligosaccharide dependent phosphorylation of ATP citrate lyase.". Adv. Enzyme Regul.. 30(): 109-117. (1990). (PMID: 2119547).
    spacer

  45. Strålfors, P.; Alemany, S. "Phosphorylation control by insulin in adipocytes is interfered with at a post-receptor step by phosphoinositol and glucosamine.". FEBS Lett.. 268(1): 169-172. (1990). (PMID: 1696549).
    spacer

  46. Alemany, S.; Puerta, J.; Guadaño, A.; Mato, J.M. "Modulation of casein kinase II activity by the polar head group of an insulin-sensitive glycosyl-phosphatidylinositol.". J. Biol. Chem.. 265(9): 4849-4852. (1990). (PMID: 2138621).
    spacer

  47. Cabrero, C.; Duce, A.M.; Ortiz, P.; Alemany, S.; Mato, J.M. "Specific loss of the high-molecular-weight form of S-adenosyl-L-methionine synthetase in human liver cirrhosis.". Hepatology. 8(6): 1530-1534. (1988). (PMID: 3192166).
    spacer

  48. Cohen, P.; Alemany, S.; Hemmings, B.A.; Resink, T.J.; Strålfors, P.; Tung, H.Y. "Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle.". Meth. Enzymol.. 159(): 390-408. (1988). (PMID: 2842604).
    spacer

  49. Cabrero, C.; Alemany, S. "Conversion of rat liver S-adenosyl-L-methionine synthetase from high-Mr form to low-Mr form by LiBr.". Biochim. Biophys. Acta. 952(3): 277-281. (1988). (PMID: 2827780).
    spacer

  50. Alemany, S.; Mato, J.M.; Strålfors, P. "Phospho-dephospho-control by insulin is mimicked by a phospho-oligosaccharide in adipocytes.". Nature. 330(6143): 77-79. (1987). (PMID: 3313056).
    spacer

  51. Cabrero, C.; Puerta, J.; Alemany, S. "Purification and comparison of two forms of S-adenosyl-L-methionine synthetase from rat liver.". Eur. J. Biochem.. 170(1-2): 299-304. (1987). (PMID: 3121322).
    spacer

  52. da Cruz e Silva, O.B.; Alemany, S.; Campbell, D.G.; Cohen, P.T. "Isolation and sequence analysis of a cDNA clone encoding the entire catalytic subunit of a type-2A protein phosphatase.". FEBS Lett.. 221(2): 415-422. (1987). (PMID: 3040474).
    spacer

  53. Alemany, S.; Pelech, S.; Brierley, C.H.; Cohen, P. "The protein phosphatases involved in cellular regulation. Evidence that dephosphorylation of glycogen phosphorylase and glycogen synthase in the glycogen and microsomal fractions of rat liver are catalysed by the same enzyme: protein phosphatase-1.". Eur. J. Biochem.. 156(1): 101-110. (1986). (PMID: 3007140).
    spacer

  54. Alemany, S.; Cohen, P. "Phosphorylase a is an allosteric inhibitor of the glycogen and microsomal forms of rat hepatic protein phosphatase-1.". FEBS Lett.. 198(2): 194-202. (1986). (PMID: 3007211).
    spacer

  55. Tung, H.Y.; Alemany, S.; Cohen, P. "The protein phosphatases involved in cellular regulation. 2. Purification, subunit structure and properties of protein phosphatases-2A0, 2A1, and 2A2 from rabbit skeletal muscle.". Eur. J. Biochem.. 148(2): 253-263. (1985). (PMID: 2985385).
    spacer

  56. Alemany, S.; Tung, H.Y.; Shenolikar, S.; Pilkis, S.J.; Cohen, P. "The protein phosphatases involved in cellular regulation. Antibody to protein phosphatase-2A as a probe of phosphatase structure and function.". Eur. J. Biochem.. 145(1): 51-56. (1984). (PMID: 6092082).
    spacer

  57. Pajares, M.A.; Alemany, S.; Varela, I.; Marin Cao, D.; Mato, J.M. "Purification and photoaffinity labelling of lipid methyltransferase from rat liver.". Biochem. J.. 223(1): 61-66. (1984). (PMID: 6497846).
    spacer

  58. Gil, M.G.; van Lookeren Campagne, M.W.; Alemany, S.; Municio, A.M.; Mato, J.M. "Effect of fatty acid anilides on the generation of arachidonic acid by human polymorphonuclear leukocytes.". FEBS Lett.. 162(1): 151-155. (1983). (PMID: 6413256).
    spacer

  59. Mato, J.M.; Alvarez Chiva, V.; Marín Cao, D.; Varela, I.; García Gil, M.; Alemany, S. "[Hormonal regulation of the synthesis of phosphatidylcholine by transmethylation].". Rev Clin Esp. 171(1): 7-10. (1983). (PMID: 6658087).
    spacer

  60. Mato, J.M.; Alemany, S. "What is the function of phospholipid N-methylation?". Biochem. J.. 213(1): 1-10. (1983). (PMID: 6311156).
    spacer

  61. Alemany, S.; Varela, I.; Mato, J.M. "Inhibition of phosphatidylcholine synthesis by vasopressin and angiotensin in rat hepatocytes.". Biochem. J.. 208(2): 453-457. (1982). (PMID: 6818955).
    spacer

  62. Alemany, S.; Varela, I.; Harper, J.F.; Mato, J.M. "Calmodulin regulation of phospholipid and fatty acid methylation by rat liver microsomes.". J. Biol. Chem.. 257(16): 9249-9251. (1982). (PMID: 6809733).
    spacer

  63. Alemany, S.; Varela, I.; Mato, J.M. "Stimulation by vasopressin and angiotensin of phospholipid methyltransferase in isolated rat hepatocytes.". FEBS Lett.. 135(1): 111-114. (1981). (PMID: 6797839).
    spacer

  64. Alemany, S.; García Gil, M.; Mato, J.M. "Regulation by guanosine 3':5'-cyclic monophosphate of phospholipid methylation during chemotaxis in Dictyostelium discoideum.". Proc. Natl. Acad. Sci. U.S.A.. 77(12): 6996-6999. (1980). (PMID: 6261233).
    spacer

  65. Castaño, J.G.; Alemany, S.; Nieto, A.; Mato, J.M. "Activation of phospholipid methyltransferase by glucagon in rat hepatocytes.". J. Biol. Chem.. 255(19): 9041-9043. (1980). (PMID: 6251072).
    spacer

  66. Gil, M.G.; Alemany, S.; Cao, D.M.; Castano, J.G.; Mato, J.M. "Calmodulin modulates phospholipid methylation in Dictyostelium discoideum.". Biochem. Biophys. Res. Commun.. 94(4): 1325-1330. (1980). (PMID: 6772186).
    spacer

 

 

 

 

 

Instituto de Investigaciones Biomédicas "Alberto Sols"
C/Arturo Duperier 4. 28029 Madrid. (Spain)
Tel +(34) 91 585 4400 // Fax +(34) 91 558 4401
Email:Info