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PUBLICACIONES

 

 

spacerTrabajos Publicados por José González Castaño
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  1. Sánchez-Lanzas, R.; Castaño, J.G. "Mitochondrial LonP1 protease is implicated in the degradation of unstable Parkinson's disease-associated DJ-1/PARK 7 missense mutants.". Sci Rep. 11(1): 7320. (2021). (PMID: 33795807).
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  2. Sánchez-Lanzas, R.; Castaño, J.G. "Inhibitors of lysosomal function or serum starvation in control or LAMP2 deficient cells do not modify the cellular levels of Parkinson disease-associated DJ-1/PARK 7 protein.". PLoS ONE. 13(7): e0201152. (2018). (PMID: 30048497).
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  3. Sánchez-Lanzas, R.; Castaño, J.G. "Lysine-Less Variants of Spinal Muscular Atrophy SMN and SMNΔ7 Proteins Are Degraded by the Proteasome Pathway.". Int J Mol Sci. 18(12): . (2017). (PMID: 29292768).
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  4. Morales-Garcia, J.A.; Gine, E.; Hernandez-Encinas, E.; Aguilar-Morante, D.; Sierra-Magro, A.; Sanz-SanCristobal, M.; Alonso-Gil, S.; Sanchez-Lanzas, R.; Castaño, J.G.; Santos, A.; Perez-Castillo, A. "CCAAT/Enhancer binding protein β silencing mitigates glial activation and neurodegeneration in a rat model of Parkinson's disease.". Sci Rep. 7(1): 13526. (2017). (PMID: 29051532).
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  5. Sánchez-Lanzas, R.; Alvarez-Castelao, B.; Bermejo, T.; Ayuso, T.; Tuñón, T.; Castaño, J.G. "Protein degradation in a LAMP-2-deficient B-lymphoblastoid cell line from a patient with Danon disease.". Biochim. Biophys. Acta. 1862(8): 1423-1432. (2016). (PMID: 27130438).
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  6. Sánchez-Lanzas, R.; Castaño, J.G. "Proteins directly interacting with mammalian 20S proteasomal subunits and ubiquitin-independent proteasomal degradation.". Biomolecules. 4(4): 1140-1154. (2014). (PMID: 25534281).
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  7. Alvarez-Castelao, B.; Gorostidi, A.; Ruíz-Martínez, J.; López de Munain, A.; Castaño, J.G. "Epitope Mapping of Antibodies to Alpha-Synuclein in LRRK2 Mutation Carriers, Idiopathic Parkinson Disease Patients, and Healthy Controls.". Front Aging Neurosci. 6(): 169. (2014). (PMID: 25076905).
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  8. Alvarez-Castelao, B.; Goethals, M.; Vandekerckhove, J.; Castaño, J.G. "Mechanism of cleavage of alpha-synuclein by the 20S proteasome and modulation of its degradation by the RedOx state of the N-terminal methionines.". Biochim. Biophys. Acta. 1843(2): 352-365. (2014). (PMID: 24315858).
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  9. Alvarez-Castelao, B.; Losada, F.; Ahicart, P.; Castaño, J.G. "The N-terminal region of Nurr1 (a.a 1-31) is essential for its efficient degradation by the ubiquitin proteasome pathway.". PLoS ONE. 8(2): e55999. (2013). (PMID: 23409108).
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  10. Alvarez-Castelao, B.; Ruiz-Rivas, C.; Castaño, J.G. "A critical appraisal of quantitative studies of protein degradation in the framework of cellular proteostasis.". Biochem Res Int. 2012(): 823597. (2012). (PMID: 23119163).
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  11. Alvarez-Castelao, B.; Muñoz, C.; Sánchez, I.; Goethals, M.; Vandekerckhove, J.; Castaño, J.G. "Reduced protein stability of human DJ-1/PARK7 L166P, linked to autosomal recessive Parkinson disease, is due to direct endoproteolytic cleavage by the proteasome.". Biochim. Biophys. Acta. 1823(2): 524-533. (2012). (PMID: 22173095).
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  12. Alvarez-Castelao, B.; Castaño, J.G. "Synphilin-1 inhibits alpha-synuclein degradation by the proteasome.". Cell. Mol. Life Sci.. 68(15): 2643-2654. (2011). (PMID: 21103907).
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  13. Alvarez-Castelao, B.; Martín-Guerrero, I.; García-Orad, A.; Castaño, J.G. "Cytomegalovirus promoter up-regulation is the major cause of increased protein levels of unstable reporter proteins after treatment of living cells with proteasome inhibitors.". J. Biol. Chem.. 284(41): 28253-28262. (2009). (PMID: 19679666).
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  14. Casarejos, M.J.; Solano, R.M.; Rodriguez-Navarro, J.A.; Gómez, A.; Perucho, J.; Castaño, J.G.; García de Yébenes, J.; Mena, M.A. "Parkin deficiency increases the resistance of midbrain neurons and glia to mild proteasome inhibition: the role of autophagy and glutathione homeostasis.". J. Neurochem.. 110(5): 1523-1537. (2009). (PMID: 19549073).
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  15. Marcilla, M.; de Castro, J.A.; Castaño, J.G.; Alvarez, I. "Infection with Salmonella typhimurium has no effect on the composition and cleavage specificity of the 20S proteasome in human lymphoid cells.". Immunology. 122(1): 131-139. (2007). (PMID: 17490436).
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  16. Kong, X.; Alvarez-Castelao, B.; Lin, Z.; Castaño, J.G.; Caro, J. "Constitutive/hypoxic degradation of HIF-alpha proteins by the proteasome is independent of von Hippel Lindau protein ubiquitylation and the transactivation activity of the protein.". J. Biol. Chem.. 282(21): 15498-15505. (2007). (PMID: 17403672).
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  17. Díaz-Hernández, M.; Valera, A.G.; Morán, M.A.; Gómez-Ramos, P.; Alvarez-Castelao, B.; Castaño, J.G.; Hernández, F.; Lucas, J.J. "Inhibition of 26S proteasome activity by huntingtin filaments but not inclusion bodies isolated from mouse and human brain.". J. Neurochem.. 98(5): 1585-1596. (2006). (PMID: 16787406).
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  18. Blanco, M.G.; Boán, F.; Barros, P.; Castaño, J.G.; Gómez-Márquez, J. "Generation of DNA double-strand breaks by two independent enzymatic activities in nuclear extracts.". J. Mol. Biol.. 351(5): 995-991006. (2005). (PMID: 16051267).
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  19. Alvarez-Castelao, B.; Castaño, J.G. "Mechanism of direct degradation of IkappaBalpha by 20S proteasome.". FEBS Lett.. 579(21): 4797-4802. (2005). (PMID: 16098527).
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  20. Martìn-Clemente, B.; Alvarez-Castelao, B.; Mayo, I.; Sierra, A.B.; Dìaz, V.; Milán, M.; Fariñas, I.; Gómez-Isla, T.; Ferrer, I.; Castaño, J.G. "alpha-Synuclein expression levels do not significantly affect proteasome function and expression in mice and stably transfected PC12 cell lines.". J. Biol. Chem.. 279(51): 52984-52990. (2004). (PMID: 15466467).
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  21. Ferrer, I.; Martín, B.; Castaño, J.G.; Lucas, J.J.; Moreno, D.; Olivé, M. "Proteasomal expression, induction of immunoproteasome subunits, and local MHC class I presentation in myofibrillar myopathy and inclusion body myositis.". J. Neuropathol. Exp. Neurol.. 63(5): 484-498. (2004). (PMID: 15198127).
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  22. Gándara, M.L.; López, P.; Hernando, R.; Castaño, J.G.; Alemany, S. "The COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activity.". Mol. Cell. Biol.. 23(20): 7377-7390. (2003). (PMID: 14517305).
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  23. Mayo, I.; Arribas, J.; Villoslada, P.; Alvarez DoForno, R.; Rodríguez-Vilariño, S.; Montalban, X.; De Sagarra, M.R.; Castaño, J.G. "The proteasome is a major autoantigen in multiple sclerosis.". Brain. 125(Pt 12): 2658-2667. (2002). (PMID: 12429593).
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  24. Lafarga, M.; Berciano, M.T.; Pena, E.; Mayo, I.; Castaño, J.G.; Bohmann, D.; Rodrigues, J.P.; Tavanez, J.P.; Carmo-Fonseca, M. "Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.". Mol. Biol. Cell. 13(8): 2771-2782. (2002). (PMID: 12181345).
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  25. Lafarga, M.; Fernández, R.; Mayo, I.; Berciano, M.T.; Castaño, J.G. "Proteasome dynamics during cell cycle in rat Schwann cells.". Glia. 38(4): 313-328. (2002). (PMID: 12007144).
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  26. Mayo, I.; Arizti, P.; Parés, A.; Oliva, J.; Doforno, R.A.; de Sagarra, M.R.; Rodés, J.; Castaño, J.G. "Antibodies against the COOH-terminal region of E. coli ClpP protease in patients with primary biliary cirrhosis.". J. Hepatol.. 33(4): 528-536. (2000). (PMID: 11059856).
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  27. Rodriguez-Vilariño, S.; Arribas, J.; Arizti, P.; Castaño, J.G. "Proteolytic processing and assembly of the C5 subunit into the proteasome complex.". J. Biol. Chem.. 275(9): 6592-6599. (2000). (PMID: 10692467).
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  28. Penela, P.; Ruiz-Gómez, A.; Castaño, J.G.; Mayor, F. "Degradation of the G protein-coupled receptor kinase 2 by the proteasome pathway.". J. Biol. Chem.. 273(52): 35238-35244. (1998). (PMID: 9857063).
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  29. Mengual, E.; Arizti, P.; Rodrigo, J.; Giménez-Amaya, J.M.; Castaño, J.G. "Immunohistochemical distribution and electron microscopic subcellular localization of the proteasome in the rat CNS.". J. Neurosci.. 16(20): 6331-6341. (1996). (PMID: 8815912).
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  30. Castaño, J.G.; Mahillo, E.; Arizti, P.; Arribas, J. "Phosphorylation of C8 and C9 subunits of the multicatalytic proteinase by casein kinase II and identification of the C8 phosphorylation sites by direct mutagenesis.". Biochemistry. 35(12): 3782-3789. (1996). (PMID: 8619999).
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  31. Arribas, J.; Arizti, P.; Castaño, J.G. "Antibodies against the C2 COOH-terminal region discriminate the active and latent forms of the multicatalytic proteinase complex.". J. Biol. Chem.. 269(17): 12858-12864. (1994). (PMID: 8175701).
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  32. Arribas, J.; Castaño, J.G. "A comparative study of the chymotrypsin-like activity of the rat liver multicatalytic proteinase and the ClpP from Escherichia coli.". J. Biol. Chem.. 268(28): 21165-21171. (1993). (PMID: 8407953).
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  33. Alvarez, L.; Avila, M.A.; Mato, J.M.; Castaño, J.G.; Varela-Nieto, I. "Insulin-like effects of inositol phosphate-glycan on messenger RNA expression in rat hepatocytes.". Mol. Endocrinol.. 5(8): 1062-1068. (1991). (PMID: 1719385).
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  34. Castaño, J.G.; Alemany, S.; Nieto, A.; Mato, J.M. "Activation of phospholipid methyltransferase by glucagon in rat hepatocytes.". J. Biol. Chem.. 255(19): 9041-9043. (1980). (PMID: 6251072).
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