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PUBLICACIONES

 

 

spacerTrabajos Publicados por Jose Ángel Morales García
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  1. Corral Nieto, Y.; Yakhine-Diop, S.M.S.; Moreno-Cruz, P.; Manrique García, L.; Gabrielly Pereira, A.; Morales-García, J.A.; Niso-Santano, M.; González-Polo, R.A.; Uribe-Carretero, E.; Durand, S.; Maiuri, M.C.; Paredes-Barquero, M.; Alegre-Cortés, E.; Canales-Cortés, S.; López de Munain, A.; Pérez-Tur, J.; Pérez-Castillo, A.; Kroemer, G.; Fuentes, J.M.; Bravo-San Pedro, J.M. "Changes in Liver Lipidomic Profile in G2019S-LRRK2 Mouse Model of Parkinson's Disease.". Cells. 12(5): . (2023). (PMID: 36899942).
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  2. Sierra-Magro, A.; Bartolome, F.; Lozano-Muñoz, D.; Alarcón-Gil, J.; Gine, E.; Sanz-SanCristobal, M.; Alonso-Gil, S.; Cortes-Canteli, M.; Carro, E.; Pérez-Castillo, A.; Morales-García, J.A. "C/EBPβ Regulates TFAM Expression, Mitochondrial Function and Autophagy in Cellular Models of Parkinson's Disease.". Int J Mol Sci. 24(2): . (2023). (PMID: 36674978).
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  3. Alarcon-Gil, J.; Sierra-Magro, A.; Morales-Garcia, J.A.; Sanz-SanCristobal, M.; Alonso-Gil, S.; Cortes-Canteli, M.; Niso-Santano, M.; Martínez-Chacón, G.; Fuentes, J.M.; Santos, A.; Perez-Castillo, A. "Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson's Disease: The Implication of Lipid Droplets and Lipophagy.". Cells. 11(15): . (2022). (PMID: 35892594).
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  4. Herrera-Arozamena, C.; Estrada-Valencia, M.; López-Caballero, P.; Pérez, C.; Morales-García, J.A.; Pérez-Castillo, A.; Sastre, E.D.; Fernández-Mendívil, C.; Duarte, P.; Michalska, P.; Lombardía, J.; Senar, S.; León, R.; López, M.G.; Rodríguez-Franco, M.I. "Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades.". J Med Chem. (): . (2022). (PMID: 35245051).
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  5. Martínez-Chacón, G.; Paredes-Barquero, M.; Yakhine-Diop, S.M.S.; Uribe-Carretero, E.; Bargiela, A.; Sabater-Arcis, M.; Morales-García, J.; Alarcón-Gil, J.; Alegre-Cortés, E.; Canales-Cortés, S.; Rodríguez-Arribas, M.; Camello, P.J.; Pedro, J.M.B.; Perez-Castillo, A.; Artero, R.; Gonzalez-Polo, R.A.; Fuentes, J.M.; Niso-Santano, M. "Neuroprotective properties of queen bee acid by autophagy induction.". Cell Biol Toxicol. (): . (2021). (PMID: 34448959).
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  6. Calleja-Conde, J.; Echeverry-Alzate, V.; Bühler, K.M.; Durán-González, P.; Morales-García, J.Á.; Segovia-Rodríguez, L.; Rodríguez de Fonseca, F.; Giné, E.; López-Moreno, J.A. "The Immune System through the Lens of Alcohol Intake and Gut Microbiota.". Int J Mol Sci. 22(14): . (2021). (PMID: 34299105).
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  7. Yakhine-Diop, S.M.S.; Morales-García, J.A.; Niso-Santano, M.; González-Polo, R.A.; Uribe-Carretero, E.; Martinez-Chacon, G.; Durand, S.; Maiuri, M.C.; Aiastui, A.; Zulaica, M.; Ruíz-Martínez, J.; López de Munain, A.; Pérez-Tur, J.; Pérez-Castillo, A.; Kroemer, G.; Bravo-San Pedro, J.M.; Fuentes, J.M. "Metabolic alterations in plasma from patients with familial and idiopathic Parkinson's disease.". Aging (Albany NY). 12(): . (2020). (PMID: 32903216).
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  8. Morales-Garcia, J.A.; Calleja-Conde, J.; Lopez-Moreno, J.A.; Alonso-Gil, S.; Sanz-SanCristobal, M.; Riba, J.; Perez-Castillo, A. "N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo.". Transl Psychiatry. 10(1): 331. (2020). (PMID: 32989216).
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  9. Herrera-Arozamena, C.; Estrada-Valencia, M.; Pérez, C.; Lagartera, L.; Morales-García, J.A.; Pérez-Castillo, A.; Franco-Gonzalez, J.F.; Michalska, P.; Duarte, P.; León, R.; López, M.G.; Mills, A.; Gago, F.; García-Yagüe, Á.J.; Fernández-Ginés, R.; Cuadrado, A.; Rodríguez-Franco, M.I. "Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties.". Eur J Med Chem. 190(): 112090. (2020). (PMID: 32018096).
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  10. Estrada-Valencia, M.; Herrera-Arozamena, C.; Pérez, C.; Viña, D.; Morales-García, J.A.; Pérez-Castillo, A.; Ramos, E.; Romero, A.; Laurini, E.; Pricl, S.; Rodríguez-Franco, M.I. "New flavonoid - N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties.". J Enzyme Inhib Med Chem. 34(1): 712-727. (2019). (PMID: 31852270).
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  11. Morales-Garcia, J.A.; Alonso-Gil, S.; Santos, Á.; Perez-Castillo, A. "Phosphodiesterase 7 Regulation in Cellular and Rodent Models of Parkinson's Disease.". Mol. Neurobiol.. (): . (2019). (PMID: 31473904).
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  12. Van Bulck, M.; Sierra-Magro, A.; Alarcon-Gil, J.; Perez-Castillo, A.; Morales-Garcia, J.A. "Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease.". Int J Mol Sci. 20(3): . (2019). (PMID: 30743990).
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  13. Estrada Valencia, M.; Herrera-Arozamena, C.; de Andrés, L.; Pérez, C.; Morales-García, J.A.; Pérez-Castillo, A.; Ramos, E.; Romero, A.; Viña, D.; Yáñez, M.; Laurini, E.; Pricl, S.; Rodríguez-Franco, M.I. "Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.". Eur J Med Chem. 156(): 534-553. (2018). (PMID: 30025348).
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  14. Morales-Garcia, J.A.; Gine, E.; Hernandez-Encinas, E.; Aguilar-Morante, D.; Sierra-Magro, A.; Sanz-SanCristobal, M.; Alonso-Gil, S.; Sanchez-Lanzas, R.; Castaño, J.G.; Santos, A.; Perez-Castillo, A. "CCAAT/Enhancer binding protein β silencing mitigates glial activation and neurodegeneration in a rat model of Parkinson's disease.". Sci Rep. 7(1): 13526. (2017). (PMID: 29051532).
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  15. Morales-Garcia, J.A.; Salado, I.G.; Sanz-San Cristobal, M.; Gil, C.; Pérez-Castillo, A.; Martínez, A.; Pérez, D.I. "Biological and Pharmacological Characterization of Benzothiazole-Based CK-1δ Inhibitors in Models of Parkinson's Disease.". ACS Omega. 2(8): 5215-5220. (2017). (PMID: 30023743).
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  16. Morales-García, J.A.; de la Fuente Revenga, M.; Alonso-Gil, S.; Rodríguez-Franco, M.I.; Feilding, A.; Perez-Castillo, A.; Riba, J. "The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro.". Sci Rep. 7(1): 5309. (2017). (PMID: 28706205).
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  17. García, A.M.; Salado, I.G.; Perez, D.I.; Brea, J.; Morales-García, J.A.; González-García, A.; Cadavid, M.I.; Loza, M.I.; Luque, F.J.; Perez-Castillo, A.; Martinez, A.; Gil, C. "Pharmacological tools based on imidazole scaffold proved the utility of PDE10A inhibitors for Parkinson's disease.". Future Med Chem. (): . (2017). (PMID: 28485668).
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  18. Morales-Garcia, J.A.; Echeverry-Alzate, V.; Alonso-Gil, S.; Sanz-SanCristobal, M.; Lopez-Moreno, J.A.; Gil, C.; Martinez, A.; Santos, A.; Perez-Castillo, A. "Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo.". Stem Cells. 35(2): 458-472. (2017). (PMID: 27538853).
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  19. Hernandez-Encinas, E.; Aguilar-Morante, D.; Morales-Garcia, J.A.; Gine, E.; Sanz-SanCristobal, M.; Santos, A.; Perez-Castillo, A. "Complement component 3 (C3) expression in the hippocampus after excitotoxic injury: role of C/EBPβ.". J Neuroinflammation. 13(1): 276. (2016). (PMID: 27769255).
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  20. Estrada, M.; Herrera-Arozamena, C.; Pérez, C.; Viña, D.; Romero, A.; Morales-García, J.A.; Pérez-Castillo, A.; Rodríguez-Franco, M.I. "New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties.". Eur J Med Chem. 121(): 376-386. (2016). (PMID: 27267007).
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  21. Estrada, M.; Pérez, C.; Soriano, E.; Laurini, E.; Romano, M.; Pricl, S.; Morales-García, J.A.; Pérez-Castillo, A.; Rodríguez-Franco, M.I. "New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with σ-1 agonism and β-secretase inhibition.". Future Med Chem. 8(11): 1191-1207. (2016). (PMID: 27402296).
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  22. de la Fuente Revenga, M.; Pérez, C.; Morales-García, J.A.; Alonso-Gil, S.; Pérez-Castillo, A.; Caignard, D.H.; Yáñez, M.; Gamo, A.M.; Rodríguez-Franco, M.I. "Neurogenic Potential Assessment and Pharmacological Characterization of 6-Methoxy-1,2,3,4-tetrahydro-β-carboline (Pinoline) and Melatonin-Pinoline Hybrids.". ACS Chem Neurosci. 6(5): 800-810. (2015). (PMID: 25815906).
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  23. de la Fuente Revenga, M.; Fernández-Sáez, N.; Herrera-Arozamena, C.; Morales-García, J.A.; Alonso-Gil, S.; Pérez-Castillo, A.; Caignard, D.H.; Rivara, S.; Rodríguez-Franco, M.I. "Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of their Neurogenic Potential.". J. Med. Chem.. (): . (2015). (PMID: 26023814).
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  24. Mestre, L.; Redondo, M.; Carrillo-Salinas, F.J.; Morales-García, J.A.; Alonso-Gil, S.; Pérez-Castillo, A.; Gil, C.; Martínez, A.; Guaza, C. "Phosphodiesterase 7 inhibitor TC3.6 ameliorates symptomatology in a model of primary progressive multiple sclerosis.". Br. J. Pharmacol.. (): . (2015). (PMID: 25994655).
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  25. Morales-Garcia, J.A.; Alonso-Gil, S.; Gil, C.; Martinez, A.; Santos, A.; Perez-Castillo, A. "Phosphodiesterase 7 Inhibition Induces Dopaminergic Neurogenesis in Hemiparkinsonian Rats.". Stem Cells Transl Med. (): . (2015). (PMID: 25925836).
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  26. Aguilar-Morante, D.; Morales-Garcia, J.A.; Santos, A.; Perez-Castillo, A. "CCAAT/enhancer binding protein β induces motility and invasion of glioblastoma cells through transcriptional regulation of the calcium binding protein S100A4.". Oncotarget. 6(6): 4369-4384. (2015). (PMID: 25738360).
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  27. Morales-Garcia, J.A.; Aguilar-Morante, D.; Hernandez-Encinas, E.; Alonso-Gil, S.; Gil, C.; Martinez, A.; Santos, A.; Perez-Castillo, A. "Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice.". Neurobiol. Aging. 36(2): 1160-1173. (2015). (PMID: 25457552).
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  28. Hernandez-Encinas, E.; Aguilar-Morante, D.; Cortes-Canteli, M.; Morales-Garcia, J.A.; Gine, E.; Santos, A.; Perez-Castillo, A. "CCAAT/enhancer binding protein ß directly regulates the expression of the complement component 3 gene in neural cells: implications for the pro-inflammatory effects of this transcription factor.". J Neuroinflammation. 12(1): 14. (2015). (PMID: 25617152).
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  29. García, A.M.; Brea, J.; Morales-García, J.A.; Perez, D.I.; González, A.; Alonso-Gil, S.; Gracia-Rubio, I.; Ros-Simó, C.; Conde, S.; Cadavid, M.I.; Loza, M.I.; Perez-Castillo, A.; Valverde, O.; Martinez, A.; Gil, C. "Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors.". J. Med. Chem.. 57(20): 8590-8607. (2014). (PMID: 25264825).
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  30. López-Iglesias, B.; Pérez, C.; Morales-García, J.A.; Alonso-Gil, S.; Pérez-Castillo, A.; Romero, A.; López, M.G.; Villarroya, M.; Conde, S.; Rodríguez-Franco, M.I. "New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.". J. Med. Chem.. 57(9): 3773-3785. (2014). (PMID: 24738476).
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  31. Morales-Garcia, J.A.; Palomo, V.; Redondo, M.; Alonso-Gil, S.; Gil, C.; Martinez, A.; Perez-Castillo, A. "Crosstalk between phosphodiesterase 7 and glycogen synthase kinase-3: two relevant therapeutic targets for neurological disorders.". ACS Chem Neurosci. 5(3): 194-204. (2014). (PMID: 24437940).
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  32. Morales-García, J.A.; Susín, C.; Alonso-Gil, S.; Pérez, D.I.; Palomo, V.; Pérez, C.; Conde, S.; Santos, A.; Gil, C.; Martínez, A.; Pérez-Castillo, A. "Glycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson disease.". ACS Chem Neurosci. 4(2): 350-360. (2013). (PMID: 23421686).
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  33. Chavarría, C.; Perez, D.I.; Pérez, C.; Morales Garcia, J.A.; Alonso-Gil, S.; Pérez-Castillo, A.; Gil, C.; Souza, J.M.; Porcal, W. "Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress.". Eur J Med Chem. 58(): 44-49. (2012). (PMID: 23085773).
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  34. Morales-Garcia, J.A.; Luna-Medina, R.; Alonso-Gil, S.; Sanz-Sancristobal, M.; Palomo, V.; Gil, C.; Santos, A.; Martinez, A.; Perez-Castillo, A. "Glycogen synthase kinase 3 inhibition promotes adult hippocampal neurogenesis in vitro and in vivo.". ACS Chem Neurosci. 3(11): 963-971. (2012). (PMID: 23173075).
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  35. Susín, C.; Morales-Garcia, J.A.; Aguilar-Morante, D.; Palomo, V.; Sanz-Sancristobal, M.; Alonso-Gil, S.; Gil, C.; Santos, A.; Martinez, A.; Perez-Castillo, A. "The new iminothiadiazole derivative VP1.14 ameliorates hippocampal damage after an excitotoxic injury.". J. Neurochem.. 122(6): 1193-1202. (2012). (PMID: 22774807).
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  36. Redondo, M.; Brea, J.; Perez, D.I.; Soteras, I.; Val, C.; Perez, C.; Morales-García, J.A.; Alonso-Gil, S.; Paul-Fernandez, N.; Martin-Alvarez, R.; Cadavid, M.I.; Loza, M.I.; Perez-Castillo, A.; Mengod, G.; Campillo, N.E.; Martinez, A.; Gil, C. "Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds.". J. Med. Chem.. 55(7): 3274-3284. (2012). (PMID: 22385507).
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  37. Palomo, V.; Perez, D.I.; Perez, C.; Morales-Garcia, J.A.; Soteras, I.; Alonso-Gil, S.; Encinas, A.; Castro, A.; Campillo, N.E.; Perez-Castillo, A.; Gil, C.; Martinez, A. "5-imino-1,2,4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3.". J. Med. Chem.. 55(4): 1645-1661. (2012). (PMID: 22257026).
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  38. Morales-Garcia, J.A.; Luna-Medina, R.; Alfaro-Cervello, C.; Cortes-Canteli, M.; Santos, A.; Garcia-Verdugo, J.M.; Perez-Castillo, A. "Peroxisome proliferator-activated receptor γ ligands regulate neural stem cell proliferation and differentiation in vitro and in vivo.". Glia. 59(2): 293-307. (2011). (PMID: 21125653).
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  39. Morales-Garcia, J.A.; Redondo, M.; Alonso-Gil, S.; Gil, C.; Perez, C.; Martinez, A.; Santos, A.; Perez-Castillo, A. "Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease.". PLoS ONE. 6(2): e17240. (2011). (PMID: 21390306).
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  40. Aguilar-Morante, D.; Morales-Garcia, J.A.; Sanz-SanCristobal, M.; Garcia-Cabezas, M.A.; Santos, A.; Perez-Castillo, A. "Inhibition of glioblastoma growth by the thiadiazolidinone compound TDZD-8.". PLoS ONE. 5(11): e13879. (2010). (PMID: 21079728).
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  41. Giné, E.; Morales-Garcia, J.A.; Perez-Castillo, A.; Santos, A. "Developmental hypothyroidism increases the expression of kainate receptors in the hippocampus and the sensitivity to kainic acid-induced seizures in the rat.". Endocrinology. 151(7): 3267-3276. (2010). (PMID: 20410204).
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  42. Morales-Garcia, J.A.; Luna-Medina, R.; Martinez, A.; Santos, A.; Perez-Castillo, A. "Anticonvulsant and neuroprotective effects of the novel calcium antagonist NP04634 on kainic acid-induced seizures in rats.". J. Neurosci. Res.. 87(16): 3687-3696. (2009). (PMID: 19565651).
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  43. Pérez Castillo, A.; Aguilar-Morante, D.; Morales-García, J.A.; Dorado, J. "Cancer stem cells and brain tumors.". Clin Transl Oncol. 10(5): 262-267. (2008). (PMID: 18490242).
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  44. Luna-Medina, R.; Cortes-Canteli, M.; Sanchez-Galiano, S.; Morales-Garcia, J.A.; Martinez, A.; Santos, A.; Perez-Castillo, A. "NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders.". J. Neurosci.. 27(21): 5766-5776. (2007). (PMID: 17522320).
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  45. Varela-Nieto, I.; Morales-Garcia, J.A.; Vigil, P.; Diaz-Casares, A.; Gorospe, I.; Sánchez-Galiano, S.; Cañon, S.; Camarero, G.; Contreras, J.; Cediel, R.; Leon, Y. "Trophic effects of insulin-like growth factor-I (IGF-I) in the inner ear.". Hear. Res.. 196(1-2): 19-25. (2004). (PMID: 15464297).
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