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PUBLICACIONES

 

 

spacerTrabajos Publicados por Angel Santos Montes
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  1. Alarcon-Gil, J.; Sierra-Magro, A.; Morales-Garcia, J.A.; Sanz-SanCristobal, M.; Alonso-Gil, S.; Cortes-Canteli, M.; Niso-Santano, M.; Martínez-Chacón, G.; Fuentes, J.M.; Santos, A.; Perez-Castillo, A. "Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson's Disease: The Implication of Lipid Droplets and Lipophagy.". Cells. 11(15): . (2022). (PMID: 35892594).
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  2. Morales-Garcia, J.A.; Gine, E.; Hernandez-Encinas, E.; Aguilar-Morante, D.; Sierra-Magro, A.; Sanz-SanCristobal, M.; Alonso-Gil, S.; Sanchez-Lanzas, R.; Castaño, J.G.; Santos, A.; Perez-Castillo, A. "CCAAT/Enhancer binding protein β silencing mitigates glial activation and neurodegeneration in a rat model of Parkinson's disease.". Sci Rep. 7(1): 13526. (2017). (PMID: 29051532).
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  3. Giné, E.; Echeverry-Alzate, V.; Lopez-Moreno, J.A.; Rodriguez de Fonseca, F.; Perez-Castillo, A.; Santos, A. "The CB1 receptor is required for the establishment of the hyperlocomotor phenotype in developmentally-induced hypothyroidism in mice.". Neuropharmacology. 116(): 132-141. (2017). (PMID: 28017790).
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  4. Morales-Garcia, J.A.; Echeverry-Alzate, V.; Alonso-Gil, S.; Sanz-SanCristobal, M.; Lopez-Moreno, J.A.; Gil, C.; Martinez, A.; Santos, A.; Perez-Castillo, A. "Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo.". Stem Cells. 35(2): 458-472. (2017). (PMID: 27538853).
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  5. Hernandez-Encinas, E.; Aguilar-Morante, D.; Morales-Garcia, J.A.; Gine, E.; Sanz-SanCristobal, M.; Santos, A.; Perez-Castillo, A. "Complement component 3 (C3) expression in the hippocampus after excitotoxic injury: role of C/EBPβ.". J Neuroinflammation. 13(1): 276. (2016). (PMID: 27769255).
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  6. Morales-Garcia, J.A.; Alonso-Gil, S.; Gil, C.; Martinez, A.; Santos, A.; Perez-Castillo, A. "Phosphodiesterase 7 Inhibition Induces Dopaminergic Neurogenesis in Hemiparkinsonian Rats.". Stem Cells Transl Med. (): . (2015). (PMID: 25925836).
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  7. Aguilar-Morante, D.; Morales-Garcia, J.A.; Santos, A.; Perez-Castillo, A. "CCAAT/enhancer binding protein β induces motility and invasion of glioblastoma cells through transcriptional regulation of the calcium binding protein S100A4.". Oncotarget. 6(6): 4369-4384. (2015). (PMID: 25738360).
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  8. Morales-Garcia, J.A.; Aguilar-Morante, D.; Hernandez-Encinas, E.; Alonso-Gil, S.; Gil, C.; Martinez, A.; Santos, A.; Perez-Castillo, A. "Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice.". Neurobiol. Aging. 36(2): 1160-1173. (2015). (PMID: 25457552).
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  9. Hernandez-Encinas, E.; Aguilar-Morante, D.; Cortes-Canteli, M.; Morales-Garcia, J.A.; Gine, E.; Santos, A.; Perez-Castillo, A. "CCAAT/enhancer binding protein ß directly regulates the expression of the complement component 3 gene in neural cells: implications for the pro-inflammatory effects of this transcription factor.". J Neuroinflammation. 12(1): 14. (2015). (PMID: 25617152).
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  10. Morales-García, J.A.; Susín, C.; Alonso-Gil, S.; Pérez, D.I.; Palomo, V.; Pérez, C.; Conde, S.; Santos, A.; Gil, C.; Martínez, A.; Pérez-Castillo, A. "Glycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson disease.". ACS Chem Neurosci. 4(2): 350-360. (2013). (PMID: 23421686).
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  11. Giné, E.; Echeverry-Alzate, V.; López-Moreno, J.A.; López-Jimenez, A.; Torres-Romero, D.; Perez-Castillo, A.; Santos, A. "Developmentally-induced hypothyroidism alters the expression of Egr-1 and Arc genes and the sensitivity to cannabinoid agonists in the hippocampus. Possible implications for memory and learning.". Mol. Cell. Endocrinol.. 365(1): 119-128. (2013). (PMID: 23079472).
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  12. Morales-Garcia, J.A.; Luna-Medina, R.; Alonso-Gil, S.; Sanz-Sancristobal, M.; Palomo, V.; Gil, C.; Santos, A.; Martinez, A.; Perez-Castillo, A. "Glycogen synthase kinase 3 inhibition promotes adult hippocampal neurogenesis in vitro and in vivo.". ACS Chem Neurosci. 3(11): 963-971. (2012). (PMID: 23173075).
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  13. Susín, C.; Morales-Garcia, J.A.; Aguilar-Morante, D.; Palomo, V.; Sanz-Sancristobal, M.; Alonso-Gil, S.; Gil, C.; Santos, A.; Martinez, A.; Perez-Castillo, A. "The new iminothiadiazole derivative VP1.14 ameliorates hippocampal damage after an excitotoxic injury.". J. Neurochem.. 122(6): 1193-1202. (2012). (PMID: 22774807).
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  14. Cortes-Canteli, M.; Aguilar-Morante, D.; Sanz-Sancristobal, M.; Megias, D.; Santos, A.; Perez-Castillo, A. "Role of C/EBPβ transcription factor in adult hippocampal neurogenesis.". PLoS ONE. 6(10): e24842. (2011). (PMID: 22003384).
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  15. Aguilar-Morante, D.; Cortes-Canteli, M.; Sanz-Sancristobal, M.; Santos, A.; Perez-Castillo, A. "Decreased CCAAT/enhancer binding protein β expression inhibits the growth of glioblastoma cells.". Neuroscience. 176(): 110-119. (2011). (PMID: 21185356).
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  16. Morales-Garcia, J.A.; Luna-Medina, R.; Alfaro-Cervello, C.; Cortes-Canteli, M.; Santos, A.; Garcia-Verdugo, J.M.; Perez-Castillo, A. "Peroxisome proliferator-activated receptor γ ligands regulate neural stem cell proliferation and differentiation in vitro and in vivo.". Glia. 59(2): 293-307. (2011). (PMID: 21125653).
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  17. Morales-Garcia, J.A.; Redondo, M.; Alonso-Gil, S.; Gil, C.; Perez, C.; Martinez, A.; Santos, A.; Perez-Castillo, A. "Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease.". PLoS ONE. 6(2): e17240. (2011). (PMID: 21390306).
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  18. Aguilar-Morante, D.; Morales-Garcia, J.A.; Sanz-SanCristobal, M.; Garcia-Cabezas, M.A.; Santos, A.; Perez-Castillo, A. "Inhibition of glioblastoma growth by the thiadiazolidinone compound TDZD-8.". PLoS ONE. 5(11): e13879. (2010). (PMID: 21079728).
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  19. Giné, E.; Morales-Garcia, J.A.; Perez-Castillo, A.; Santos, A. "Developmental hypothyroidism increases the expression of kainate receptors in the hippocampus and the sensitivity to kainic acid-induced seizures in the rat.". Endocrinology. 151(7): 3267-3276. (2010). (PMID: 20410204).
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  20. Morales-Garcia, J.A.; Luna-Medina, R.; Martinez, A.; Santos, A.; Perez-Castillo, A. "Anticonvulsant and neuroprotective effects of the novel calcium antagonist NP04634 on kainic acid-induced seizures in rats.". J. Neurosci. Res.. 87(16): 3687-3696. (2009). (PMID: 19565651).
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  21. Cocca, C.; Dorado, J.; Calvo, E.; López, J.A.; Santos, A.; Perez-Castillo, A. "15-Deoxi-Delta(12,14)-prostaglandin J2 is a tubulin-binding agent that destabilizes microtubules and induces mitotic arrest.". Biochem. Pharmacol.. 78(10): 1330-1339. (2009). (PMID: 19576185).
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  22. Martinez, B.; Rodrigues, T.B.; Gine, E.; Kaninda, J.P.; Perez-Castillo, A.; Santos, A. "Hypothyroidism decreases the biogenesis in free mitochondria and neuronal oxygen consumption in the cerebral cortex of developing rats.". Endocrinology. 150(8): 3953-3959. (2009). (PMID: 19389834).
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  23. Asúa, T.; Bilbao, A.; Gorriti, M.A.; Lopez-Moreno, J.A.; Del Mar Alvarez, M.; Navarro, M.; Rodríguez de Fonseca, F.; Perez-Castillo, A.; Santos, A. "Implication of the endocannabinoid system in the locomotor hyperactivity associated with congenital hypothyroidism.". Endocrinology. 149(5): 2657-2666. (2008). (PMID: 18218697).
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  24. Cortes-Canteli, M.; Luna-Medina, R.; Sanz-Sancristobal, M.; Alvarez-Barrientos, A.; Santos, A.; Perez-Castillo, A. "CCAAT/enhancer binding protein beta deficiency provides cerebral protection following excitotoxic injury.". J. Cell. Sci.. 121(Pt 8): 1224-1234. (2008). (PMID: 18388310).
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  25. Luna-Medina, R.; Cortes-Canteli, M.; Sanchez-Galiano, S.; Morales-Garcia, J.A.; Martinez, A.; Santos, A.; Perez-Castillo, A. "NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders.". J. Neurosci.. 27(21): 5766-5776. (2007). (PMID: 17522320).
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  26. Sanchez-Rodriguez, J.; Kaninda-Tshilumbu, J.P.; Santos, A.; Perez-Castillo, A. "The spot 14 protein inhibits growth and induces differentiation and cell death of human MCF-7 breast cancer cells.". Biochem J. 390(Pt 1): 57-65. (2005). (PMID: 15819613).
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  27. Luna-Medina, R.; Cortes-Canteli, M.; Alonso, M.; Santos, A.; Martínez, A.; Perez-Castillo, A. "Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation.". J. Biol. Chem.. 280(22): 21453-21462. (2005). (PMID: 15817469).
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  28. Martínez, B.; Pérez-Castillo, A.; Santos, A. "The mitochondrial respiratory complex I is a target for 15-deoxy-delta12,14-prostaglandin J2 action.". J. Lipid Res.. 46(4): 736-743. (2005). (PMID: 15654126).
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  29. Pignatelli, M.; Sánchez-Rodríguez, J.; Santos, A.; Perez-Castillo, A. "15-deoxy-Delta-12,14-prostaglandin J2 induces programmed cell death of breast cancer cells by a pleiotropic mechanism.". Carcinogenesis. 26(1): 81-92. (2005). (PMID: 15485993).
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  30. Alvarez, M.; Perez-Castillo, A.; Santos, A. "Thyroid hormone regulates Galphai1 gene expression in the rat cerebellar cortex during post-natal development.". J. Neurochem.. 92(2): 395-404. (2005). (PMID: 15663487).
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  31. Pignatelli, M.; Cocca, C.; Santos, A.; Perez-Castillo, A. "Enhancement of BRCA1 gene expression by the peroxisome proliferator-activated receptor gamma in the MCF-7 breast cancer cell line.". Oncogene. 22(35): 5446-5450. (2003). (PMID: 12934104).
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  32. Pignatelli, M.; Luna-Medina, R.; Pérez-Rendón, A.; Santos, A.; Perez-Castillo, A. "The transcription factor early growth response factor-1 (EGR-1) promotes apoptosis of neuroblastoma cells.". Biochem. J.. 373(Pt 3): 739-746. (2003). (PMID: 12755686).
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  33. Cortés-Canteli, M.; Pignatelli, M.; Santos, A.; Perez-Castillo, A. "CCAAT/enhancer-binding protein beta plays a regulatory role in differentiation and apoptosis of neuroblastoma cells.". J. Biol. Chem.. 277(7): 5460-5467. (2002). (PMID: 11733516).
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  34. Pignatelli, M.; Cortés-Canteli, M.; Lai, C.; Santos, A.; Perez-Castillo, A. "The peroxisome proliferator-activated receptor gamma is an inhibitor of ErbBs activity in human breast cancer cells.". J. Cell. Sci.. 114(Pt 22): 4117-4126. (2001). (PMID: 11739643).
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  35. Martinez, B.; del Hoyo, P.; Martin, M.A.; Arenas, J.; Perez-Castillo, A.; Santos, A. "Thyroid hormone regulates oxidative phosphorylation in the cerebral cortex and striatum of neonatal rats.". J. Neurochem.. 78(5): 1054-1063. (2001). (PMID: 11553679).
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  36. Menéndez-Hurtado, A.; Santos, A.; Pérez-Castillo, A. "Characterization of the promoter region of the rat CCAAT/enhancer-binding protein alpha gene and regulation by thyroid hormone in rat immortalized brown adipocytes.". Endocrinology. 141(11): 4164-4170. (2000). (PMID: 11089549).
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  37. Pignatelli, M.; Cortés-Canteli, M.; Santos, A.; Perez-Castillo, A. "Involvement of the NGFI-A gene in the differentiation of neuroblastoma cells.". FEBS Lett.. 461(1-2): 37-42. (1999). (PMID: 10561492).
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  38. Rodríguez-Manzaneque, J.C.; Pérez-Castillo, A.; Santos, A. "Control by thyroid hormone of NGFI-A gene expression in lung: regulation of NGFI-A promoter activity.". Mol. Cell. Endocrinol.. 141(1-2): 101-110. (1998). (PMID: 9723891).
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  39. Vega-Núñez, E.; Alvarez, A.M.; Menéndez-Hurtado, A.; Santos, A.; Perez-Castillo, A. "Neuronal mitochondrial morphology and transmembrane potential are severely altered by hypothyroidism during rat brain development.". Endocrinology. 138(9): 3771-3778. (1997). (PMID: 9275064).
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  40. Menéndez-Hurtado, A.; Vega-Núñez, E.; Santos, A.; Perez-Castillo, A. "Regulation by thyroid hormone and retinoic acid of the CCAAT/enhancer binding protein alpha and beta genes during liver development.". Biochem. Biophys. Res. Commun.. 234(3): 605-610. (1997). (PMID: 9175760).
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  41. Moreno, B.; Rodríguez-Manzaneque, J.C.; Pérez-Castillo, A.; Santos, A. "Thyroid hormone controls the expression of insulin-like growth factor I receptor gene at different levels in lung and heart of developing and adult rats.". Endocrinology. 138(3): 1194-1203. (1997). (PMID: 9048627).
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  42. Rodríguez-García, M.; Jolín, T.; Santos, A.; Pérez-Castillo, A. "Effect of perinatal hypothyroidism on the developmental regulation of rat pituitary growth hormone and thyrotropin genes.". Endocrinology. 136(10): 4339-4350. (1995). (PMID: 7664653).
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  43. Vega-Núñez, E.; Menéndez-Hurtado, A.; Garesse, R.; Santos, A.; Perez-Castillo, A. "Thyroid hormone-regulated brain mitochondrial genes revealed by differential cDNA cloning.". J. Clin. Invest.. 96(2): 893-899. (1995). (PMID: 7635984).
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  44. Mellström, B.; Pipaón, C.; Naranjo, J.R.; Perez-Castillo, A.; Santos, A. "Differential effect of thyroid hormone on NGFI-A gene expression in developing rat brain.". Endocrinology. 135(2): 583-588. (1994). (PMID: 8033806).
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  45. Castelló, A.; Rodríguez-Manzaneque, J.C.; Camps, M.; Pérez-Castillo, A.; Testar, X.; Palacín, M.; Santos, A.; Zorzano, A. "Perinatal hypothyroidism impairs the normal transition of GLUT4 and GLUT1 glucose transporters from fetal to neonatal levels in heart and brown adipose tissue. Evidence for tissue-specific regulation of GLUT4 expression by thyroid hormone.". J. Biol. Chem.. 269(8): 5905-5912. (1994). (PMID: 8119934).
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  46. Perez-Castillo, A.; Hernandez, A.; Pipaon, C.; Santos, A.; Obregon, M.J. "Multiple regulation of S14 gene expression during brown fat differentiation.". Endocrinology. 133(2): 545-552. (1993). (PMID: 8393767).
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  47. Pipaon, C.; Santos, A.; Perez-Castillo, A. "Thyroid hormone up-regulates NGFI-A gene expression in rat brain during development.". J. Biol. Chem.. 267(1): 21-23. (1992). (PMID: 1370444).
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  48. Santos, A.; Perez-Castillo, A.; Wong, N.C.; Oppenheimer, J.H. "Labile proteins are necessary for T3 induction of growth hormone mRNA in normal rat pituitary and rat pituitary tumor cells.". J. Biol. Chem.. 262(35): 16880-16884. (1987). (PMID: 3680275).
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