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PUBLICACIONES

 

 

spacerTrabajos Publicados por Juan Carlos Lacal Sanjuan
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  1. Ramírez de Molina, A.; de la Cueva, A.; Machado-Pinilla, R.; Rodriguez-Fanjul, V.; Gomez del Pulgar, T.; Cebrian, A.; Perona, R.; Lacal, J.C. "Acid ceramidase as a chemotherapeutic target to overcome resistance to the antitumoral effect of choline kinase α inhibition.". Curr Cancer Drug Targets. 12(6): 617-624. (2012). (PMID: 22515519).
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  2. Pintzas, A.; Zhivotovsky, B.; Workman, P.; Clarke, P.A.; Linardopoulos, S.; Martinou, J.C.; Lacal, J.C.; Robine, S.; Nasioulas, G.; Andera, L. "Sensitization of (colon) cancer cells to death receptor related therapies: a report from the FP6-ONCODEATH research consortium.". Cancer Biol. Ther.. 13(7): 458-466. (2012). (PMID: 22406997).
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  3. Casado-Vela, J.; Cebrián, A.; Gómez del Pulgar, M.T.; Lacal, J.C. "Approaches for the study of cancer: towards the integration of genomics, proteomics and metabolomics.". Clin Transl Oncol. 13(9): 617-628. (2011). (PMID: 21865133).
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  4. Casado-Vela, J.; Gómez del Pulgar, T.; Cebrián, A.; Alvarez-Ayerza, N.; Lacal, J.C. "Human urine proteomics: building a list of human urine cancer biomarkers.". Expert Rev Proteomics. 8(3): 347-360. (2011). (PMID: 21679116).
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  5. Casado-Vela, J.; Cebrián, A.; Gómez del Pulgar, M.T.; Sánchez-López, E.; Vilaseca, M.; Menchén, L.; Diema, C.; Sellés-Marchart, S.; Martínez-Esteso, M.J.; Yubero, N.; Bru-Martínez, R.; Lacal, J.C.; Lacal, J.C. "Lights and shadows of proteomic technologies for the study of protein species including isoforms, splicing variants and protein post-translational modifications.". Proteomics. 11(4): 590-603. (2011). (PMID: 21229583).
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  6. Gallego-Ortega, D.; Ramirez de Molina, A.; Ramos, M.A.; Valdes-Mora, F.; Barderas, M.G.; Sarmentero-Estrada, J.; Lacal, J.C. "Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment.". PLoS ONE. 4(11): e7819. (2009). (PMID: 19915674).
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  7. Bañez-Coronel, M.; Ramírez de Molina, A.; Rodríguez-González, A.; Sarmentero, J.; Ramos, M.A.; García-Cabezas, M.A.; García-Oroz, L.; Lacal, J.C. "Choline kinase alpha depletion selectively kills tumoral cells.". Curr Cancer Drug Targets. 8(8): 709-719. (2008). (PMID: 19075594).
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  8. Gallego-Ortega, D.; Ramirez De Molina, A.; Gutierrez, R.; Ramos, M.A.; Sarmentero, J.; Cejas, P.; Nistal, M.; González Barón, M.; Lacal, J.C. "Generation and characterization of monoclonal antibodies against choline kinase alpha and their potential use as diagnostic tools in cancer.". Int. J. Oncol.. 29(2): 335-340. (2006). (PMID: 16820874).
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  9. Matter, C.M.; Wyss, M.T.; Meier, P.; Späth, N.; von Lukowicz, T.; Lohmann, C.; Weber, B.; Ramirez de Molina, A.; Lacal, J.C.; Ametamey, S.M.; von Schulthess, G.K.; Lüscher, T.F.; Kaufmann, P.A.; Buck, A. "18F-choline images murine atherosclerotic plaques ex vivo.". Arterioscler. Thromb. Vasc. Biol.. 26(3): 584-589. (2006). (PMID: 16357314).
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  10. Al-Saffar, N.M.; Troy, H.; Ramírez de Molina, A.; Jackson, L.E.; Madhu, B.; Griffiths, J.R.; Leach, M.O.; Workman, P.; Lacal, J.C.; Judson, I.R.; Chung, Y.L. "Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models.". Cancer Res. 66(1): 427-434. (2006). (PMID: 16397258).
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  11. Gómez del Pulgar, T.; Benitah, S.A.; Valerón, P.F.; Espina, C.; Lacal, J.C. "Rho GTPase expression in tumourigenesis: evidence for a significant link.". Bioessays. 27(6): 602-613. (2005). (PMID: 15892119).
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  12. Benitah, S.A.; Valerón, P.F.; van Aelst, L.; Marshall, C.J.; Lacal, J.C. "Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation.". Biochim. Biophys. Acta. 1705(2): 121-132. (2004). (PMID: 15588766).
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  13. Rodríguez-González, A.; Ramirez de Molina, A.; Fernández, F.; Lacal, J.C. "Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action.". Oncogene. 23(50): 8247-8259. (2004). (PMID: 15378008).
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  14. Conejo-García, A.; Báñez-Coronel, M.; Sánchez-Martín, R.M.; Rodríguez-González, A.; Ramos, A.; Ramírez de Molina, A.; Espinosa, A.; Gallo, M.A.; Campos, J.M.; Lacal, J.C. "Influence of the linker in bispyridium compounds on the inhibition of human choline kinase.". J. Med. Chem.. 47(22): 5433-5440. (2004). (PMID: 15481981).
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  15. Ramírez de Molina, A.; Báñez-Coronel, M.; Gutiérrez, R.; Rodríguez-González, A.; Olmeda, D.; Megías, D.; Lacal, J.C. "Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression.". Cancer Res.. 64(18): 6732-6739. (2004). (PMID: 15374991).
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  16. Ramírez de Molina, A.; Rodríguez-González, A.; Lacal, J.C. "From Ras signalling to ChoK inhibitors: a further advance in anticancer drug design.". Cancer Lett.. 206(2): 137-148. (2004). (PMID: 15013519).
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  17. Aznar, S.; Fernández-Valerón, P.; Espina, C.; Lacal, J.C. "Rho GTPases: potential candidates for anticancer therapy.". Cancer Lett.. 206(2): 181-191. (2004). (PMID: 15013523).
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  18. Rodríguez-González, A.; Ramírez de Molina, A.; Fernández, F.; Ramos, M.A.; del Carmen Núñez, M.; Campos, J.; Lacal, J.C. "Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells.". Oncogene. 22(55): 8803-8812. (2003). (PMID: 14654777).
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  19. Benitah, S.A.; Valerón, P.F.; Lacal, J.C. "ROCK and nuclear factor-kappaB-dependent activation of cyclooxygenase-2 by Rho GTPases: effects on tumor growth and therapeutic consequences.". Mol. Biol. Cell. 14(7): 3041-3054. (2003). (PMID: 12857884).
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  20. Conejo-García, A.; Campos, J.; Sánchez, R.M.; Rodríguez-González, A.; Lacal, J.C.; Gallo, M.A.; Espinosa, A. "Choline kinase inhibitory effect and antiproliferative activity of new 1,1',1"-(benzene-1,3,5-triylmethylene)tris[4-[(disubstituted)amino]pyridinium] tribromides.". Eur J Med Chem. 38(1): 109-116. (2003). (PMID: 12593921).
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  21. Benitah, S.A.; Valerón, P.F.; Rui, H.; Lacal, J.C. "STAT5a activation mediates the epithelial to mesenchymal transition induced by oncogenic RhoA.". Mol. Biol. Cell. 14(1): 40-53. (2003). (PMID: 12529425).
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  22. Lucas, L.; Penalva, V.; Ramírez de Molina, A.; Del Peso, L.; Lacal, J.C. "Modulation of phospholipase D by Ras proteins mediated by its effectors Ral-GDS, PI3K and Raf-1.". Int. J. Oncol.. 21(3): 477-485. (2002). (PMID: 12168089).
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  23. Sánchez-Pérez, I.; Benitah, S.A.; Martínez-Gomariz, M.; Lacal, J.C.; Perona, R. "Cell stress and MEKK1-mediated c-Jun activation modulate NFkappaB activity and cell viability.". Mol. Biol. Cell. 13(8): 2933-2945. (2002). (PMID: 12181357).
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  24. Campos, J.M.; Núñez, M.C.; Sánchez, R.M.; Gómez-Vidal, J.A.; Rodríguez-González, A.; Báñez, M.; Gallo, M.A.; Lacal, J.C.; Espinosa, A. "Quantitative structure-activity relationships for a series of symmetrical bisquaternary anticancer compounds.". Bioorg. Med. Chem.. 10(7): 2215-2231. (2002). (PMID: 11983519).
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  25. Ramírez de Molina, A.; Gutiérrez, R.; Ramos, M.A.; Silva, J.M.; Silva, J.; Bonilla, F.; Sánchez, J.J.; Lacal, J.C. "Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy.". Oncogene. 21(27): 4317-4322. (2002). (PMID: 12082619).
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  26. Ramírez de Molina, A.; Penalva, V.; Lucas, L.; Lacal, J.C. "Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K.". Oncogene. 21(6): 937-946. (2002). (PMID: 11840339).
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  27. Aznar, S.; Valerón, P.F.; del Rincon, S.V.; Pérez, L.F.; Perona, R.; Lacal, J.C. "Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation.". Mol. Biol. Cell. 12(10): 3282-3294. (2001). (PMID: 11598209).
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  28. Ramírez de Molina, A.; Rodríguez-González, A.; Penalva, V.; Lucas, L.; Lacal, J.C. "Inhibition of ChoK is an efficient antitumor strategy for Harvey-, Kirsten-, and N-ras-transformed cells.". Biochem. Biophys. Res. Commun.. 285(4): 873-879. (2001). (PMID: 11467831).
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  29. Aznar, S.; Lacal, J.C. "Rho signals to cell growth and apoptosis.". Cancer Lett.. 165(1): 1-10. (2001). (PMID: 11248412).
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  30. Campos, J.; del Carmen Núñez, M.; Rodríguez, V.; Entrena, A.; Hernández-Alcoceba, R.; Fernández, F.; Lacal, J.C.; Gallo, M.A.; Espinosa, A. "LUMO energy of model compounds of bispyridinium compounds as an index for the inhibition of choline kinase.". Eur J Med Chem. 36(3): 215-225. (2001). (PMID: 11337100).
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  31. Lucas, L.; Hernández-Alcoceba, R.; Penalva, V.; Lacal, J.C. "Modulation of phospholipase D by hexadecylphosphorylcholine: a putative novel mechanism for its antitumoral activity.". Oncogene. 20(9): 1110-1117. (2001). (PMID: 11314048).
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  32. Embade, N.; Valerón, P.F.; Aznar, S.; López-Collazo, E.; Lacal, J.C. "Apoptosis induced by Rac GTPase correlates with induction of FasL and ceramides production.". Mol. Biol. Cell. 11(12): 4347-4358. (2000). (PMID: 11102528).
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  33. Lucas, L.; del Peso, L.; Rodríguez, P.; Penalva, V.; Lacal, J.C. "Ras protein is involved in the physiological regulation of phospholipase D by platelet derived growth factor.". Oncogene. 19(3): 431-437. (2000). (PMID: 10656691).
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  34. Hernández-Alcoceba, R.; Fernández, F.; Lacal, J.C. "In vivo antitumor activity of choline kinase inhibitors: a novel target for anticancer drug discovery.". Cancer Res.. 59(13): 3112-3118. (1999). (PMID: 10397253).
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  35. Montaner, S.; Perona, R.; Saniger, L.; Lacal, J.C. "Activation of serum response factor by RhoA is mediated by the nuclear factor-kappaB and C/EBP transcription factors.". J. Biol. Chem.. 274(13): 8506-8515. (1999). (PMID: 10085083).
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  36. Esteve, P.; Embade, N.; Perona, R.; Jiménez, B.; del Peso, L.; León, J.; Arends, M.; Miki, T.; Lacal, J.C. "Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway.". Oncogene. 17(14): 1855-1869. (1998). (PMID: 9778052).
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  37. Montaner, S.; Perona, R.; Saniger, L.; Lacal, J.C. "Multiple signalling pathways lead to the activation of the nuclear factor kappaB by the Rho family of GTPases.". J. Biol. Chem.. 273(21): 12779-12785. (1998). (PMID: 9582304).
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  38. Carnero, A.; Lacal, J.C. "Wortmannin, an inhibitor of phosphatidyl-inositol 3-kinase, induces oocyte maturation through a MPF-MAPK-dependent pathway.". FEBS Lett.. 422(2): 155-159. (1998). (PMID: 9489996).
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  39. Di Donato, A.; Lacal, J.C.; Di Duca, M.; Giampuzzi, M.; Ghiggeri, G.; Gusmano, R. "Micro-injection of recombinant lysyl oxidase blocks oncogenic p21-Ha-Ras and progesterone effects on Xenopus laevis oocyte maturation.". FEBS Lett.. 419(1): 63-68. (1997). (PMID: 9426221).
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  40. del Peso, L.; Hernández-Alcoceba, R.; Embade, N.; Carnero, A.; Esteve, P.; Paje, C.; Lacal, J.C. "Rho proteins induce metastatic properties in vivo.". Oncogene. 15(25): 3047-3057. (1997). (PMID: 9444953).
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  41. Hernández-Alcoceba, R.; Saniger, L.; Campos, J.; Núñez, M.C.; Khaless, F.; Gallo, M.A.; Espinosa, A.; Lacal, J.C. "Choline kinase inhibitors as a novel approach for antiproliferative drug design.". Oncogene. 15(19): 2289-2301. (1997). (PMID: 9393874).
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  42. Coso, O.A.; Montaner, S.; Fromm, C.; Lacal, J.C.; Prywes, R.; Teramoto, H.; Gutkind, J.S. "Signaling from G protein-coupled receptors to the c-jun promoter involves the MEF2 transcription factor. Evidence for a novel c-jun amino-terminal kinase-independent pathway.". J. Biol. Chem.. 272(33): 20691-20697. (1997). (PMID: 9252389).
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  43. Lacal, J.C. "Regulation of proliferation and apoptosis by Ras and Rho GTPases through specific phospholipid-dependent signaling.". FEBS Lett.. 410(1): 73-77. (1997). (PMID: 9247126).
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  44. del Peso, L.; Lucas, L.; Esteve, P.; Lacal, J.C. "Activation of phospholipase D by growth factors and oncogenes in murine fibroblasts follow alternative but cross-talking pathways.". Biochem. J.. 322 ( Pt 2)(): 519-528. (1997). (PMID: 9065772).
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  45. Perona, R.; Montaner, S.; Saniger, L.; Sánchez-Pérez, I.; Bravo, R.; Lacal, J.C. "Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins.". Genes Dev.. 11(4): 463-475. (1997). (PMID: 9042860).
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  46. del Peso, L.; Hernández, R.; Esteve, P.; Lacal, J.C. "Activation of phospholipase D by ras proteins is independent of protein kinase C.". J. Cell. Biochem.. 61(4): 599-608. (1996). (PMID: 8806084).
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  47. Esteve, P.; del Peso, L.; Lacal, J.C. "Induction of apoptosis by rho in NIH 3T3 cells requires two complementary signals. Ceramides function as a progression factor for apoptosis.". Oncogene. 11(12): 2657-2665. (1995). (PMID: 8545123).
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  48. Carnero, A.; Lacal, J.C. "Activation of intracellular kinases in Xenopus oocytes by p21ras and phospholipases: a comparative study.". Mol. Cell. Biol.. 15(2): 1094-1101. (1995). (PMID: 7823925).
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  49. Jiménez, B.; del Peso, L.; Montaner, S.; Esteve, P.; Lacal, J.C. "Generation of phosphorylcholine as an essential event in the activation of Raf-1 and MAP-kinases in growth factors-induced mitogenic stimulation.". J. Cell. Biochem.. 57(1): 141-149. (1995). (PMID: 7721953).
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  50. Carnero, A.; Jiménez, B.; Lacal, J.C. "Progesterone but not ras requires MPF for in vivo activation of MAPK and S6 KII: MAPK is an essential conexion point of both signaling pathways.". J. Cell. Biochem.. 55(4): 465-476. (1994). (PMID: 7962177).
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  51. Carnero, A.; Cuadrado, A.; del Peso, L.; Lacal, J.C. "Activation of type D phospholipase by serum stimulation and ras-induced transformation in NIH3T3 cells.". Oncogene. 9(5): 1387-1395. (1994). (PMID: 8152799).
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  52. Cuadrado, A.; Carnero, A.; Dolfi, F.; Jiménez, B.; Lacal, J.C. "Phosphorylcholine: a novel second messenger essential for mitogenic activity of growth factors.". Oncogene. 8(11): 2959-2968. (1993). (PMID: 8414498).
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  53. Dolfi, F.; Carnero, A.; Cuadrado, A.; Ramponi, G.; Lacal, J.C. "Acylphosphatase synergizes with progesterone during maturation of Xenopus laevis oocytes.". FEBS Lett.. 327(3): 265-270. (1993). (PMID: 8394242).
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  54. Mollinedo, F.; Perez-Sala, D.; Gajate, C.; Jimenez, B.; Rodriguez, P.; Lacal, J.C. "Localization of rap1 and rap2 proteins in the gelatinase-containing granules of human neutrophils.". FEBS Lett.. 326(1-3): 209-214. (1993). (PMID: 8391995).
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  55. Dolfi, F.; Carnero, A.; Ramponi, G.; Lacal, J.C. "Microinjection of acylphosphatase blocks Xenopus laevis oocytes maturation induced by ras-p21.". FEBS Lett.. 326(1-3): 167-170. (1993). (PMID: 8391991).
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  56. Perona, R.; Esteve, P.; Jiménez, B.; Ballestero, R.P.; Ramón y Cajal, S.; Lacal, J.C. "Tumorigenic activity of rho genes from Aplysia californica.". Oncogene. 8(5): 1285-1292. (1993). (PMID: 8479750).
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  57. Lacal, J.C.; Cuadrado, A.; Jones, J.E.; Trotta, R.; Burstein, D.E.; Thomson, T.; Pellicer, A. "Regulation of protein kinase C activity in neuronal differentiation induced by the N-ras oncogene in PC-12 cells.". Mol. Cell. Biol.. 10(6): 2983-2990. (1990). (PMID: 2188105).
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