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PUBLICACIONES

 

 

spacerTrabajos Publicados por Ángela María Martínez Valverde
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  1. Bernal, S.; Prieto, I.; Kavanagh, M.; Del Real, I.H.; La Manna, S.; Lázaro, I.; Quiceno, H.; López-Sanz, L.; Picatoste, B.; Valdecantos, M.P.; Mas-Fontao, S.; Sala-Vila, A.; Valverde, Á.M.; Marasco, D.; Egido, J.; Gómez-Guerrero, C. "Development of SOCS1 mimetics as novel approach to harmonize inflammation, oxidative stress, and fibrogenesis in metabolic dysfunction-associated steatotic liver disease.". Redox Biol. 84(): 103670. (2025). (PMID: 40373621).
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  2. Alén, R.; Garcia-Martinez, I.; Cobo-Vuilleumier, N.; Fernández-Millán, E.; Gallardo-Villanueva, P.; Ferreira, V.; Izquierdo, M.; Moro, M.Á.; Lizasoain, I.; Nieto, N.; Gauthier, B.R.; Valverde, Á.M. "Effect of lipotoxic hepatocyte-derived extracellular vesicles in pancreas inflammation: essential role of macrophage TLR4 in beta cell functionality.". Diabetologia. (): . (2025). (PMID: 40387904).
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  3. Fernández-González, I.; Freire-Agulleiro, O.; Ferreira, V.; Silveira-Loureiro, M.; Rial-Pensado, E.; Garrido-Gil, P.; Martínez, G.; Rada, P.; Labandeira-García, J.L.; Mittag, J.; González-García, I.; Diéguez, C.; Nogueiras, R.; Valverde, Á.M.; Davis, R.J.; Sabio, G.; Barca-Mayo, O.; López, M. "JNK1 in SF1 neurons regulates the central action of thyroid hormones on hepatic lipid metabolism.". Mol Metab. (): 102170. (2025). (PMID: 40419019).
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  4. Cuadrado, A.; Cazalla, E.; Bach, A.; Bathish, B.; Naidu, S.D.; DeNicola, G.M.; Dinkova-Kostova, A.T.; Fernández-Ginés, R.; Grochot-Przeczek, A.; Hayes, J.D.; Kensler, T.W.; León, R.; Liby, K.T.; López, M.G.; Manda, G.; Shivakumar, A.K.; Hakomäki, H.; Moerland, J.A.; Motohashi, H.; Rojo, A.I.; Sykiotis, G.P.; Taguchi, K.; Valverde, Á.M.; Yamamoto, M.; Levonen, A.L. "Health position paper and redox perspectives - Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases.". Redox Biol. (): 103569. (2025). (PMID: 40059038).
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  5. Baquero, C.; Iniesta-González, M.; Palao, N.; Fernández-Infante, C.; Cueto-Remacha, M.; Mancebo, J.; de la Cámara-Fuentes, S.; Rodrigo-Faus, M.; Valdecantos, M.P.; Valverde, A.M.; Sequera, C.; Manzano, S.; Cuesta, Á.M.; Gutierrez-Uzquiza, A.; Bragado, P.; Guerrero, C.; Porras, A. "Platelet C3G protects from liver fibrosis, while enhancing tumor growth through regulation of the immune response.". J Pathol. (): . (2025). (PMID: 39989399).
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  6. Marañón, P.; Isaza, S.C.; Rey, E.; Rada, P.; García-García, Y.; Dear, J.W.; García-Monzón, C.; Valverde, Á.M.; Egea, J.; González-Rodríguez, Á. "BMP6 participates in the molecular mechanisms involved in APAP hepatotoxicity.". Arch Toxicol. (): . (2025). (PMID: 39827450).
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  7. Valdecantos, M.P.; Ruiz, L.; Folgueira, C.; Rada, P.; Gomez-Santos, B.; Solas, M.; Hitos, A.B.; Field, J.; Francisco, V.; Escalona-Garrido, C.; Zagmutt, S.; Calderon-Dominguez, M.; Mera, P.; Garcia-Martinez, I.; Maymó-Masip, E.; Grajales, D.; Alen, R.; Mora, A.; Sáinz, N.; Vides-Urrestarazu, I.; Vilarrasa, N.; Arbones-Mainar, J.M.; Zaragoza, C.; Moreno-Aliaga, M.J.; Aspichueta, P.; Fernández-Veledo, S.; Vendrell, J.; Serra, D.; Herrero, L.; Schreiber, R.; Zechner, R.; Sabio, G.; Hornigold, D.; Rondinone, C.M.; Jermutus, L.; Grimsby, J.; Valverde, Á.M. "The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk.". Nat Commun. 15(1): 10342. (2024). (PMID: 39609390).
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  8. Ardanaz, C.G.; de la Cruz, A.; Minhas, P.S.; Hernández-Martín, N.; Pozo, M.Á.; Valdecantos, M.P.; Valverde, Á.M.; Villa-Valverde, P.; Elizalde-Horcada, M.; Puerta, E.; Ramírez, M.J.; Ortega, J.E.; Urbiola, A.; Ederra, C.; Ariz, M.; Ortiz-de-Solórzano, C.; Fernández-Irigoyen, J.; Santamaría, E.; Karsenty, G.; Brüning, J.C.; Solas, M. "Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis.". Sci Adv. 10(42): eadp1115. (2024). (PMID: 39423276).
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  9. Rada, P.; Carceller-López, E.; Hitos, A.B.; Gómez-Santos, B.; Fernández-Hernández, C.; Rey, E.; Pose-Utrilla, J.; García-Monzón, C.; González-Rodríguez, Á.; Sabio, G.; García, A.; Aspichueta, P.; Iglesias, T.; Valverde, Á.M. "Protein Kinase D2 modulates hepatic insulin sensitivity in male mice.". Mol Metab. (): 102045. (2024). (PMID: 39401614).
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  10. Zhang, M.; Barroso, E.; Peña, L.; Rada, P.; Valverde, Á.M.; Wahli, W.; Palomer, X.; Vázquez-Carrera, M. "PPARβ/δ attenuates hepatic fibrosis by reducing SMAD3 phosphorylation and p300 levels via AMPK in hepatic stellate cells.". Biomed Pharmacother. 179(): 117303. (2024). (PMID: 39153437).
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  11. Gonzalez-Sanchez, E.; Vaquero, J.; Caballero-Diaz, D.; Grzelak, J.; Fusté, N.P.; Bertran, E.; Amengual, J.; Garcia-Saez, J.; Martín-Mur, B.; Gut, M.; Esteve-Codina, A.; Alay, A.; Coulouarn, C.; Calero-Perez, S.; Valdecantos, P.; Valverde, A.M.; Sánchez, A.; Herrera, B.; Fabregat, I. "The hepatocyte epidermal growth factor receptor (EGFR) pathway regulates the cellular interactome within the liver fibrotic niche.". J Pathol. (): . (2024). (PMID: 38872438).
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  12. Ferreira, V.; Folgueira, C.; Montes-San Lorenzo, Á.; Rodríguez-López, A.; Gonzalez-Iglesias, E.; Zubiaur, P.; Abad-Santos, F.; Sabio, G.; Rada, P.; Valverde, Á.M. "Estrogens prevent the hypothalamus-periphery crosstalk induced by olanzapine intraperitoneal treatment in female mice: Effects on brown/beige adipose tissues and liver.". Biochim Biophys Acta Mol Basis Dis. 1870(5): 167227. (2024). (PMID: 38733774).
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  13. García-Sáez, J.; Figueroa-Fuentes, M.; González-Corralejo, C.; Roncero, C.; Lazcanoiturburu, N.; Gutiérrez-Uzquiza, Á.; Vaquero, J.; González-Sánchez, E.; Bhutia, K.; Calero-Pérez, S.; Maina, F.; Traba, J.; Valverde, Á.M.; Fabregat, I.; Herrera, B.; Sánchez, A. "Uncovering a Novel Functional Interaction Between Adult Hepatic Progenitor Cells, Inflammation and EGFR Signaling During Bile Acids-Induced Injury.". Int J Biol Sci. 20(7): 2339-2355. (2024). (PMID: 38725853).
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  14. Marañón, P.; Rey, E.; Isaza, S.C.; Wu, H.; Rada, P.; Choya-Foces, C.; Martínez-Ruiz, A.; Martín, M.Á.; Ramos, S.; García-Monzón, C.; Cubero, F.J.; Valverde, Á.M.; González-Rodríguez, Á. "Inhibition of ALK3-mediated signalling pathway protects against acetaminophen-induced liver injury.". Redox Biol. 71(): 103088. (2024). (PMID: 38401290).
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  15. Caparrós, E.; García-Martinez, I.; Pedro Zapater, .; Lucía Madero, .; Valverde, Á.M.; Ana Gutiérrez, .; Francés, R. "An altered expression of miR-376a-3p and miR-20a-5p in peripheral blood exosomes regulates the autophagy and inflammatory systemic substrates, and relates to the smoking habit and age in Crohn's disease.". FASEB J. 38(2): e23418. (2024). (PMID: 38226870).
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  16. Jurado-Aguilar, J.; Barroso, E.; Bernard, M.; Zhang, M.; Peyman, M.; Rada, P.; Valverde, Á.M.; Wahli, W.; Palomer, X.; Vázquez-Carrera, M. "GDF15 activates AMPK and inhibits gluconeogenesis and fibrosis in the liver by attenuating the TGF-β1/SMAD3 pathway.". Metabolism. 152(): 155772. (2024). (PMID: 38176644).
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  17. Fernández-Ginés, R.; Encinar, J.A.; Escoll, M.; Carnicero-Senabre, D.; Jiménez-Villegas, J.; García-Yagüe, Á.J.; González-Rodríguez, Á.; Garcia-Martinez, I.; M Valverde, Á.; Rojo, A.I.; Cuadrado, A. "Specific targeting of the NRF2/β-TrCP axis promotes beneficial effects in NASH.". Redox Biol. 69(): 103027. (2024). (PMID: 38184999).
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  18. Gallardo-Villanueva, P.; Fernández-Marcelo, T.; Villamayor, L.; Valverde, A.M.; Ramos, S.; Fernández-Millán, E.; Martín, M.A. "Synergistic Effect of a Flavonoid-Rich Cocoa-Carob Blend and Metformin in Preserving Pancreatic Beta Cells in Zucker Diabetic Fatty Rats.". Nutrients. 16(2): . (2024). (PMID: 38257166).
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  19. Rodriguez-Ramiro, I.; Pastor-Fernández, A.; López-Aceituno, J.L.; Garcia-Dominguez, E.; Sierra-Ramirez, A.; Valverde, A.M.; Martinez-Pastor, B.; Efeyan, A.; Gomez-Cabrera, M.C.; Viña, J.; Fernandez-Marcos, P.J. "Pharmacological and genetic increases in liver NADPH levels ameliorate NASH progression in female mice.". Free Radic Biol Med. (): . (2023). (PMID: 38036067).
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  20. Peyman, M.; Barroso, E.; Turcu, A.L.; Estrany, F.; Smith, D.; Jurado-Aguilar, J.; Rada, P.; Morisseau, C.; Hammock, B.D.; Valverde, Á.M.; Palomer, X.; Galdeano, C.; Vázquez, S.; Vázquez-Carrera, M. "Soluble epoxide hydrolase-targeting PROTAC activates AMPK and inhibits endoplasmic reticulum stress.". Biomed Pharmacother. 168(): 115667. (2023). (PMID: 37826940).
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  21. Zhang, M.; Barroso, E.; Ruart, M.; Peña, L.; Peyman, M.; Aguilar-Recarte, D.; Montori-Grau, M.; Rada, P.; Cugat, C.; Montironi, C.; Zarei, M.; Jurado-Aguilar, J.; Camins, A.; Balsinde, J.; Valverde, Á.M.; Wahli, W.; Palomer, X.; Vázquez-Carrera, M. "Elafibranor upregulates the EMT-inducer S100A4 via PPARβ/δ.". Biomed Pharmacother. 167(): 115623. (2023). (PMID: 37783154).
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  22. Laiglesia, L.M.; Escoté, X.; Sáinz, N.; Felix-Soriano, E.; Santamaría, E.; Collantes, M.; Fernández-Galilea, M.; Colón-Mesa, I.; Martínez-Fernández, L.; Quesada-López, T.; Quesada-Vázquez, S.; Rodríguez-Ortigosa, C.; Arbones-Mainar, J.M.; Valverde, Á.M.; Martínez, J.A.; Dalli, J.; Herrero, L.; Lorente-Cebrián, S.; Villarroya, F.; Moreno-Aliaga, M.J. "Maresin 1 activates brown adipose tissue and promotes browning of white adipose tissue in mice.". Mol Metab. 74(): 101749. (2023). (PMID: 37271337).
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  23. Garcia-Martinez, I.; Alen, R.; Pereira, L.; Povo-Retana, A.; Astudillo, A.M.; Hitos, A.B.; Gomez-Hurtado, I.; Lopez-Collazo, E.; Boscá, L.; Francés, R.; Lizasoain, I.; Moro, M.Á.; Balsinde, J.; Izquierdo, M.; Valverde, Á.M. "Saturated fatty acid-enriched small extracellular vesicles mediate a crosstalk inducing liver inflammation and hepatocyte insulin resistance.". JHEP Rep. 5(8): 100756. (2023). (PMID: 37360906).
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  24. Carrasco, A.G.; Izquierdo-Lahuerta, A.; Valverde, Á.M.; Ni, L.; Flores-Salguero, E.; Coward, R.J.; Medina-Gómez, G. "The protective role of peroxisome proliferator-activated receptor gamma in lipotoxic podocytes.". Biochim Biophys Acta Mol Cell Biol Lipids. 1868(7): 159329. (2023). (PMID: 37156296).
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  25. Marsal-Beltran, A.; Rodríguez-Castellano, A.; Astiarraga, B.; Calvo, E.; Rada, P.; Madeira, A.; Rodríguez-Peña, M.M.; Llauradó, G.; Núñez-Roa, C.; Gómez-Santos, B.; Maymó-Masip, E.; Bosch, R.; Frutos, M.D.; Moreno-Navarrete, J.M.; Ramos-Molina, B.; Aspichueta, P.; Joven, J.; Fernández-Real, J.M.; Quer, J.C.; Valverde, Á.M.; Pardo, A.; Vendrell, J.; Ceperuelo-Mallafré, V.; Fernández-Veledo, S. "Protective effects of the succinate/SUCNR1 axis on damaged hepatocytes in NAFLD.". Metabolism. (): 155630. (2023). (PMID: 37315889).
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  26. Ferreira, V.; Folgueira, C.; García-Altares, M.; Guillén, M.; Ruíz-Rosario, M.; DiNunzio, G.; Garcia-Martinez, I.; Alen, R.; Bookmeyer, C.; Jones, J.G.; Cigudosa, J.C.; López-Larrubia, P.; Correig-Blanchar, X.; Davis, R.J.; Sabio, G.; Rada, P.; Valverde, Á.M. "Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewiring that prevents hepatic steatosis in male mice treated with olanzapine via intraperitoneal: Additional effects of PTP1B inhibition.". Redox Biol. 63(): 102741. (2023). (PMID: 37230004).
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  27. Marañón, P.; Isaza, S.C.; Fernández-García, C.E.; Rey, E.; Gallego-Durán, R.; Montero-Vallejo, R.; de Cía, J.R.; Ampuero, J.; Valverde, Á.M.; Romero-Gómez, M.; García-Monzón, C.; González-Rodríguez, Á. "Circulating bone morphogenetic protein 8A is a novel biomarker to predict advanced liver fibrosis.". Biomark Res. 11(1): 46. (2023). (PMID: 37106416).
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  28. Frutos, M.F.; Pardo-Marqués, V.; Torrecilla-Parra, M.; Rada, P.; Pérez-García, A.; Martín-Martín, Y.; de la Peña, G.; Gómez, A.; Toledano-Zaragoza, A.; Gómez-Coronado, D.; Casarejos, M.J.; Solís, J.M.; Rotllán, N.; Pastor, Ó.; Ledesma, M.D.; Valverde, Á.M.; Busto, R.; Ramírez, C.M. ""MiR-7 controls cholesterol biosynthesis through posttranscriptional regulation of DHCR24 expression".". Biochim Biophys Acta Gene Regul Mech. (): 194938. (2023). (PMID: 37086967).
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  29. Vranic, M.; Ahmed, F.; Hetty, S.; Sarsenbayeva, A.; Ferreira, V.; Fanni, G.; Valverde, Á.M.; Eriksson, J.W.; Pereira, M.J. "Effects of the second-generation antipsychotic drugs aripiprazole and olanzapine on human adipocyte differentiation.". Mol Cell Endocrinol. 561(): 111828. (2023). (PMID: 36526026).
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  30. Aguilar-Recarte, D.; Barroso, E.; Zhang, M.; Rada, P.; Pizarro-Delgado, J.; Peña, L.; Palomer, X.; Valverde, Á.M.; Wahli, W.; Vázquez-Carrera, M. "A positive feedback loop between AMPK and GDF15 promotes metformin antidiabetic effects.". Pharmacol Res. (): 106578. (2022). (PMID: 36435271).
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  31. Lazcanoiturburu, N.; García-Sáez, J.; González-Corralejo, C.; Roncero, C.; Sanz, J.; Martín-Rodríguez, C.; Valdecantos, M.P.; Martínez-Palacián, A.; Almalé, L.; Bragado, P.; Calero-Pérez, S.; Fernández, A.; García-Bravo, M.; Guerra, C.; Montoliu, L.; Segovia, J.C.; Valverde, Á.M.; Fabregat, I.; Herrera, B.; Sánchez, A. "Lack of EGFR catalytic activity in hepatocytes improves liver regeneration following DDC-induced cholestatic injury by promoting a pro-restorative inflammatory response.". J Pathol. 258(3): 312-324. (2022). (PMID: 36148647).
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  32. Ferreira, V.; Folgueira, C.; Guillén, M.; Zubiaur, P.; Navares, M.; Sarsenbayeva, A.; López-Larrubia, P.; Eriksson, J.W.; Pereira, M.J.; Abad-Santos, F.; Sabio, G.; Rada, P.; Valverde, Á.M. "Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight.". Metabolism. 137(): 155335. (2022). (PMID: 36272468).
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  33. Navarro Del Hierro, J.; Cantero-Bahillo, E.; Fernández-Felipe, M.T.; García-Risco, M.R.; Fornari, T.; Rada, P.; Doblado, L.; Ferreira, V.; Hitos, A.B.; Valverde, Á.M.; Monsalve, M.; Martin, D. "Effects of a Mealworm (Tenebrio molitor) Extract on Metabolic Syndrome-Related Pathologies: In Vitro Insulin Sensitivity, Inflammatory Response, Hypolipidemic Activity and Oxidative Stress.". Insects. 13(10): . (2022). (PMID: 36292844).
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  34. Barahona, I.; Rada, P.; Calero-Pérez, S.; Grillo-Risco, R.; Pereira, L.; Soler-Vázquez, M.C.; LaIglesia, L.M.; Moreno-Aliaga, M.J.; Herrero, L.; Serra, D.; García-Monzon, C.; González-Rodriguez, Á.; Balsinde, J.; García-García, F.; Valdecantos, M.P.; Valverde, Á.M. "Ptpn1 deletion protects oval cells against lipoapoptosis by favoring lipid droplet formation and dynamics.". Cell Death Differ. (): . (2022). (PMID: 35681014).
    spacer -/- mice with NAFLD opens therapeutic perspectives to ensure OC viability and plasticity under lipotoxic liver damage.')" value="Abstract">

  35. Grajales, D.; Vázquez, P.; Alén, R.; Hitos, A.B.; Valverde, Á.M. "Attenuation of Olanzapine-Induced Endoplasmic Reticulum Stress Improves Insulin Secretion in Pancreatic Beta Cells.". Metabolites. 12(5): . (2022). (PMID: 35629947).
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  36. Rada, P.; Lamballe, F.; Carceller-López, E.; Hitos, A.B.; Sequera, C.; Maina, F.; Valverde, Á.M. "Enhanced Wild-Type MET Receptor Levels in Mouse Hepatocytes Attenuates Insulin-Mediated Signaling.". Cells. 11(5): . (2022). (PMID: 35269415).
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  37. Grajales, D.; Vázquez, P.; Ruíz-Rosario, M.; Tudurí, E.; Mirasierra, M.; Ferreira, V.; Hitos, A.B.; Koller, D.; Zubiaur, P.; Cigudosa, J.C.; Abad-Santos, F.; Vallejo, M.; Quesada, I.; Tirosh, B.; Leibowitz, G.; Valverde, Á.M. "The second-generation antipsychotic drug aripiprazole modulates the serotonergic system in pancreatic islets and induces beta cell dysfunction in female mice.". Diabetologia. (): . (2021). (PMID: 34932133).
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  38. Pescador, N.; Francisco, V.; Vázquez, P.; Esquinas, E.M.; González-Páramos, C.; Valdecantos, M.P.; García-Martínez, I.; Urrutia, A.A.; Ruiz, L.; Escalona-Garrido, C.; Foretz, M.; Viollet, B.; Fernández-Moreno, M.Á.; Calle-Pascual, A.L.; Obregón, M.J.; Aragonés, J.; Valverde, Á.M. "Metformin reduces macrophage HIF1α-dependent proinflammatory signaling to restore brown adipocyte function in vitro.". Redox Biol. 48(): 102171. (2021). (PMID: 34736121).
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  39. Vinaixa, M.; Canelles, S.; González-Murillo, Á.; Ferreira, V.; Grajales, D.; Guerra-Cantera, S.; Campillo-Calatayud, A.; Ramírez-Orellana, M.; Yanes, Ó.; Frago, L.M.; Valverde, Á.M.; Barrios, V. "Increased Hypothalamic Anti-Inflammatory Mediators in Non-Diabetic Insulin Receptor Substrate 2-Deficient Mice.". Cells. 10(8): . (2021). (PMID: 34440853).
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  40. Cano-Cano, F.; Alcalde-Estévez, E.; Gómez-Jaramillo, L.; Iturregui, M.; Sánchez-Fernández, E.M.; García Fernández, J.M.; Ortiz Mellet, C.; Campos-Caro, A.; López-Tinoco, C.; Aguilar-Diosdado, M.; Valverde, Á.M.; Arroba, A.I. "Anti-Inflammatory (M2) Response Is Induced by a sp2-Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy.". Front Immunol. 12(): 632132. (2021). (PMID: 33815384).
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  41. Brea, R.; Valdecantos, P.; Rada, P.; Alen, R.; García-Monzón, C.; Boscá, L.; Fuertes-Agudo, M.; Casado, M.; Martín-Sanz, P.; Valverde, Á.M. "Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress.". Aging (Albany NY). 13(6): 7800-7827. (2021). (PMID: 33780353).
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  42. Klionsky, D.J.; [ .., ].; Bartolome, A.; [ .., ].; Cuadrado, A.; [ .., ].; Escalante, R.; [ .., ].; García-Sanz, P.; [ .., ].; Lastres-Becker, I.; [ .., ].; León, Y.; [ .., ].; Martin-Sanz, P.; [ .., ].; Pajares, M.; [ .., ].; Rojo, A.I.; [ .., ].; Valverde, A.M.; [ .., ].; Varela-Nieto, I.; [ .., ].; Villalobo, A.; [ .., ].; Vincent, O.; [ .., ].; Tong, C.K. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).". Autophagy. (): 1-382. (2021). (PMID: 33634751).
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  43. Rubio, C.; Lizárraga, E.; Álvarez-Cilleros, D.; Pérez-Pardo, P.; Sanmartín-Salinas, P.; Toledo-Lobo, M.V.; Alvarez, C.; Escrivá, F.; Fernández-Lobato, M.; Guijarro, L.G.; Valverde, A.M.; Carrascosa, J.M. "Aging in male Wistar rats associates with changes in intestinal microbiota, gut structure and cholecystokinin-mediated gut-brain axis function.". J Gerontol A Biol Sci Med Sci. (): . (2020). (PMID: 33315062).
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  44. de Toro-Martín, J.; Fernández-Marcelo, T.; González-Rodríguez, Á.; Escrivá, F.; Valverde, Á.M.; Álvarez, C.; Fernández-Millán, E. "Defective liver glycogen autophagy related to hyperinsulinemia in intrauterine growth-restricted newborn wistar rats.". Sci Rep. 10(1): 17651. (2020). (PMID: 33077861).
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  45. Escalona-Garrido, C.; Vázquez, P.; Mera, P.; Zagmutt, S.; García-Casarrubios, E.; Montero-Pedrazuela, A.; Rey-Stolle, F.; Guadaño-Ferraz, A.; Rupérez, F.J.; Serra, D.; Herrero, L.; Obregon, M.J.; Valverde, Á.M. "Moderate SIRT1 overexpression protects against inflammation of brown adipose tissue.". Mol Metab. (): 101097. (2020). (PMID: 33049408).
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  46. Rada, P.; González-Rodríguez, Á.; García-Monzón, C.; Valverde, Á.M. "Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?". Cell Death Dis. 11(9): 802. (2020). (PMID: 32978374).
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  47. Hernández, C.; Arroba, A.I.; Bogdanov, P.; Ramos, H.; Simó-Servat, O.; Simó, R.; Valverde, A.M. "Effect of Topical Administration of Somatostatin on Retinal Inflammation and Neurodegeneration in an Experimental Model of Diabetes.". J Clin Med. 9(8): . (2020). (PMID: 32784955).
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  48. Garcia-Martinez, I.; Alen, R.; Rada, P.; Valverde, A.M. "Insights Into Extracellular Vesicles as Biomarker of NAFLD Pathogenesis.". Front Med (Lausanne). 7(): 395. (2020). (PMID: 32850903).
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  49. Forno, F.; Maatuf, Y.; Boukeileh, S.; Dipta, P.; Mahameed, M.; Darawshi, O.; Ferreira, V.; Rada, P.; Garcia-Martinez, I.; Gross, E.; Priel, A.; Martinez Valverde, A.; Tirosh, B. "Aripiprazole cytotoxicity coincides with activation of the unfolded protein response in human hepatic cells.". J. Pharmacol. Exp. Ther.. (): . (2020). (PMID: 32554435).
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  50. Ferreira, V.; Grajales, D.; Valverde, Á.M. "Adipose tissue as a target for second-generation (atypical) antipsychotics: A molecular view.". Biochim Biophys Acta Mol Cell Biol Lipids. 1865(2): 158534. (2020). (PMID: 31672575).
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  51. Rubio, C.; Puerto, M.; García-Rodríquez, J.J.; Lu, V.B.; García-Martínez, I.; Alén, R.; Sanmartín-Salinas, P.; Toledo-Lobo, M.V.; Saiz, J.; Ruperez, J.; Barbas, C.; Menchén, L.; Gribble, F.M.; Reimann, F.; Guijarro, L.G.; Carrascosa, J.M.; Valverde, Á.M. "Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice.". Mol Metab. 35(): 100954. (2020). (PMID: 32244182).
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  112. García-Ruiz, I.; Solís-Muñoz, P.; Gómez-Izquierdo, E.; Muñoz-Yagüe, M.T.; Valverde, A.M.; Solís-Herruzo, J.A. "Protein-tyrosine phosphatases are involved in interferon resistance associated with insulin resistance in HepG2 cells and obese mice.". J. Biol. Chem.. 287(23): 19564-19573. (2012). (PMID: 22493491).
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  113. Ortiz, C.; Caja, L.; Bertran, E.; Gonzalez-Rodriguez, Á.; Valverde, Á.M.; Fabregat, I.; Sancho, P. "Protein-tyrosine phosphatase 1B (PTP1B) deficiency confers resistance to transforming growth factor-β (TGF-β)-induced suppressor effects in hepatocytes.". J. Biol. Chem.. 287(19): 15263-15274. (2012). (PMID: 22427664).
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  114. González-Rodríguez, A.; Más-Gutierrez, J.A.; Mirasierra, M.; Fernandez-Pérez, A.; Lee, Y.J.; Ko, H.J.; Kim, J.K.; Romanos, E.; Carrascosa, J.M.; Ros, M.; Vallejo, M.; Rondinone, C.M.; Valverde, A.M. "Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging.". Aging Cell. 11(2): 284-296. (2012). (PMID: 22221695).
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  115. Burgos-Ramos, E.; González-Rodríguez, A.; Canelles, S.; Baquedano, E.; Frago, L.M.; Revuelta-Cervantes, J.; Gómez-Ambrosi, J.; Frühbeck, G.; Chowen, J.A.; Argente, J.; Valverde, A.M.; Barrios, V. "Differential insulin receptor substrate-1 (IRS1)-related modulation of neuropeptide Y and proopiomelanocortin expression in nondiabetic and diabetic IRS2-/- mice.". Endocrinology. 153(3): 1129-1140. (2012). (PMID: 22210743).
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  116. Murillo-Cuesta, S.; Camarero, G.; González-Rodríguez, A.; De La Rosa, L.R.; Burks, D.J.; Avendaño, C.; Valverde, A.M.; Varela-Nieto, I. "Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function.". Mol. Med.. 18(): 260-269. (2012). (PMID: 22160220).
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  117. Ortega-Molina, A.; Efeyan, A.; Lopez-Guadamillas, E.; Muñoz-Martin, M.; Gómez-López, G.; Cañamero, M.; Mulero, F.; Pastor, J.; Martinez, S.; Romanos, E.; Mar Gonzalez-Barroso, M.; Rial, E.; Valverde, A.M.; Bischoff, J.R.; Serrano, M. "Pten positively regulates brown adipose function, energy expenditure, and longevity.". Cell Metab.. 15(3): 382-394. (2012). (PMID: 22405073).
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  118. Valverde, A.M.; González-Rodríguez, A. "IRS2 and PTP1B: Two opposite modulators of hepatic insulin signalling.". Arch. Physiol. Biochem.. 117(3): 105-115. (2011). (PMID: 21401320).
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  119. Revuelta-Cervantes, J.; Mayoral, R.; Miranda, S.; González-Rodríguez, A.; Fernández, M.; Martín-Sanz, P.; Valverde, A.M. "Protein Tyrosine Phosphatase 1B (PTP1B) deficiency accelerates hepatic regeneration in mice.". Am. J. Pathol.. 178(4): 1591-1604. (2011). (PMID: 21406170).
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  120. García-Monzón, C.; Lo Iacono, O.; Mayoral, R.; González-Rodríguez, A.; Miquilena-Colina, M.E.; Lozano-Rodríguez, T.; García-Pozo, L.; Vargas-Castrillón, J.; Casado, M.; Boscá, L.; Valverde, A.M.; Martín-Sanz, P. "Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C.". J. Hepatol.. 54(1): 142-152. (2011). (PMID: 20888662).
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  121. Escrivá, F.; González-Rodriguez, A.; Fernández-Millán, E.; Rondinone, C.M.; Alvarez, C.; Valverde, A.M. "PTP1B deficiency enhances liver growth during suckling by increasing the expression of insulin-like growth factor-I.". J. Cell. Physiol.. 225(1): 214-222. (2010). (PMID: 20506299).
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  122. Miranda, S.; González-Rodríguez, A.; Revuelta-Cervantes, J.; Rondinone, C.M.; Valverde, A.M. "Beneficial effects of PTP1B deficiency on brown adipocyte differentiation and protection against apoptosis induced by pro- and anti-inflammatory stimuli.". Cell. Signal.. 22(4): 645-659. (2010). (PMID: 20026400).
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  123. González-Rodríguez, A.; Mas Gutierrez, J.A.; Sanz-González, S.; Ros, M.; Burks, D.J.; Valverde, A.M. "Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice.". Diabetes. 59(3): 588-599. (2010). (PMID: 20028942).
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  124. Mayoral, R.; Valverde, A.M.; Llorente Izquierdo, C.; González-Rodríguez, A.; Boscá, L.; Martín-Sanz, P. "Impairment of transforming growth factor beta signaling in caveolin-1-deficient hepatocytes: role in liver regeneration.". J. Biol. Chem.. 285(6): 3633-3642. (2010). (PMID: 19966340).
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  125. Fernandez-Marcos, P.J.; Pantoja, C.; Gonzalez-Rodriguez, A.; Martin, N.; Flores, J.M.; Valverde, A.M.; Hara, E.; Serrano, M. "Normal proliferation and tumorigenesis but impaired pancreatic function in mice lacking the cell cycle regulator sei1.". PLoS ONE. 5(1): e8744. (2010). (PMID: 20090907).
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  126. González-Rodriguez, A.; Alba, J.; Zimmerman, V.; Kozma, S.C.; Valverde, A.M. "S6K1 deficiency protects against apoptosis in hepatocytes.". Hepatology. 50(1): 216-229. (2009). (PMID: 19437488).
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  127. González-Rodriguez, A.; Nevado, C.; Escrivá, F.; Sesti, G.; Rondinone, C.M.; Benito, M.; Valverde, A.M. "PTP1B deficiency increases glucose uptake in neonatal hepatocytes: involvement of IRA/GLUT2 complexes.". Am. J. Physiol. Gastrointest. Liver Physiol.. 295(2): G338-47. (2008). (PMID: 18535291).
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  128. Nevado, C.; Benito, M.; Valverde, A.M. "Role of insulin receptor and balance in insulin receptor isoforms A and B in regulation of apoptosis in simian virus 40-immortalized neonatal hepatocytes.". Mol. Biol. Cell. 19(3): 1185-1198. (2008). (PMID: 18172021).
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  129. González-Rodriguez, A.; Escribano, O.; Alba, J.; Rondinone, C.M.; Benito, M.; Valverde, A.M. "Levels of protein tyrosine phosphatase 1B determine susceptibility to apoptosis in serum-deprived hepatocytes.". J. Cell. Physiol.. 212(1): 76-88. (2007). (PMID: 17323378).
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  130. Naïmi, M.; Gautier, N.; Chaussade, C.; Valverde, A.M.; Accili, D.; Van Obberghen, E. "Nuclear forkhead box O1 controls and integrates key signaling pathways in hepatocytes.". Endocrinology. 148(5): 2424-2434. (2007). (PMID: 17303659).
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  131. Escribano, O.; Arribas, M.; Valverde, A.M.; Benito, M. "IRS-3 mediates insulin-induced glucose uptake in differentiated IRS-2(-/-) brown adipocytes.". Mol. Cell. Endocrinol.. 268(1-2): 1-9. (2007). (PMID: 17316975).
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  132. Gonzalez-Rodriguez, A.; Clampit, J.E.; Escribano, O.; Benito, M.; Rondinone, C.M.; Valverde, A.M. "Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes.". Endocrinology. 148(2): 594-608. (2007). (PMID: 17068137).
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  133. Nieto-Vazquez, I.; Fernández-Veledo, S.; de Alvaro, C.; Rondinone, C.M.; Valverde, A.M.; Lorenzo, M. "Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-alpha-induced insulin resistance.". Diabetes. 56(2): 404-413. (2007). (PMID: 17259385).
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Instituto de Investigaciones Biomédicas "Alberto Sols"
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