27 ene | 2024 Targeting cancer stem cell OXPHOS with tailored ruthenium complexes as a new anti-cancer strategy. Alcalá, S , Villarino, L, Ruiz-Cañas, L , Couceiro, JR, Martínez-Calvo, M, Palencia-Campos, A , Navarro, D , Cabezas-Sainz, P, Rodriguez-Arabaolaza, I , Cordero-Barreal, A , Trilla-Fuertes, L, Rubiolo, JA, Batres-Ramos, S , Vallespinos, M , González-Páramos, C , Rodríguez, J, Gámez-Pozo, A , Vara, JÁF, Fernández, SF, Berlinches, AB, Moreno-Mata, N, Redondo, AMT, Carrato, A, Hermann, PC, Sánchez, L, Torrente, S, Fernández-Moreno, MÁ , Mascareñas, JL, Sainz, B . J Exp Clin Cancer Res - 43 (1) : 33 (PMID: 38281027) (doi:10.1186/s13046-023-02931-7)
27 nov | 2023 Dysfunction of Drosophila mitochondrial carrier homolog (Mtch) alters apoptosis and disturbs development. González, C , Martínez-Sánchez, L , Clemente, P , Toivonen, JM, Arredondo, JJ , Fernández-Moreno, MÁ , Carrodeguas, JA. FEBS Open Bio (PMID: 38013241) (doi:10.1002/2211-5463.13742)
22 ago | 2023 Immunometabolic actions of trabectedin and lurbinectedin on human macrophages: relevance for their anti-tumor activity. Povo-Retana, A , Fariñas, M, Landauro-Vera, R , Mojena, M , Alvarez-Lucena, C , Fernández-Moreno, MA , Castrillo, A , de la Rosa Medina, JV, Sánchez-García, S , Foguet, C, Mas, F, Marin, S, Cascante, M, Boscá, L . Front Immunol - 14 : 1211068 (PMID: 37675104) (doi:10.3389/fimmu.2023.1211068)
8 abr | 2022 Multicentric Standardization of Protocols for the Diagnosis of Human Mitochondrial Respiratory Chain Defects. Bujan, N, Morén, C, García-García, FJ, Blázquez, A, Carnicer, C, Cortés, AB, González, C , López-Gallardo, E, Lozano, E, Moliner, S, Gort, L, Tobías, E, Delmiro, A, Martin, MÁ, Fernández-Moreno, MÁ , Ruiz-Pesini, E, Garcia-Arumí, E, Rodríguez-Aguilera, JC, Garrabou, G. Antioxidants (Basel) - 11 (4) (PMID: 35453428) (doi:10.3390/antiox11040741)
19 oct | 2021 Metformin reduces macrophage HIF1α-dependent proinflammatory signaling to restore brown adipocyte function in vitro. Pescador, N , Francisco, V , Vázquez, P , Esquinas, EM , González-Páramos, C , Valdecantos, MP , García-Martínez, I , Urrutia, AA, Ruiz, L , Escalona-Garrido, C , Foretz, M, Viollet, B, Fernández-Moreno, MÁ , Calle-Pascual, AL, Obregón, MJ , Aragonés, J, Valverde, ÁM . Redox Biol - 48 : 102171 (PMID: 34736121) (doi:10.1016/j.redox.2021.102171)
16 oct | 2020 Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells. Valle, S , Alcalá, S , Martin-Hijano, L , Cabezas-Sáinz, P, Navarro, D , Muñoz, ER, Yuste, L , Tiwary, K, Walter, K, Ruiz-Cañas, L , Alonso-Nocelo, M , Rubiolo, JA, González-Arnay, E, Heeschen, C, Garcia-Bermejo, L, Hermann, PC, Sánchez, L, Sancho, P, Fernández-Moreno, MÁ , Sainz, B . Nat Commun - 11 (1) : 5265 (PMID: 33067432) (doi:10.1038/s41467-020-18954-z)
1 ago | 2020 Metabolic labeling of RNA uncovers the contribution of transcription and decay rates on hypoxia-induced changes in RNA levels. Tiana, M , Acosta-Iborra, B , Hernández, R , Galiana, C , Fernández-Moreno, MÁ , Jimenez, B , Del Peso, L . RNA - 26 (8) : 1006-1022 (PMID: 32295863) (doi:10.1261/rna.072611.119)
16 jul | 2020 c-Src functionality controls self-renewal and glucose metabolism in MCF7 breast cancer stem cells. Mayoral-Varo, V , Calcabrini, A , Sánchez-Bailón, MP , Martínez-Costa, ÓH , González-Páramos, C , Ciordia, S, Hardisson, D, Aragón, JJ , Fernández-Moreno, MÁ , Martín-Pérez, J . PLoS ONE - 15 (7) : e0235850 (PMID: 32673341) (doi:10.1371/journal.pone.0235850)
29 mayo | 2020 ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity. Alcalá, S , Sancho, P, Martinelli, P, Navarro, D , Pedrero, C , Martín-Hijano, L , Valle, S , Earl, J, Rodríguez-Serrano, M, Ruiz-Cañas, L , Rojas, K , Carrato, A, García-Bermejo, L, Fernández-Moreno, MÁ , Hermann, PC, Sainz, B . Nat Commun - 11 (1) : 2682 (PMID: 32472071) (doi:10.1038/s41467-020-16395-2)
17 mar | 2020 Correction: Enhanced tumorigenicity by mitochondrial DNA mild mutations. Cruz-Bermúdez, A , Vallejo, CG , Vicente-Blanco, RJ , Gallardo, ME , Fernández-Moreno, MÁ , Quintanilla, M , Garesse, R . Oncotarget - 11 (11) : 1006 (PMID: 32215189) (doi:10.18632/oncotarget.27522)
3 oct | 2018 Pathogenic variants in glutamyl-tRNAGln amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder. Friederich, MW, Timal, S, Powell, CA, Dallabona, C, Kurolap, A, Palacios-Zambrano, S , Bratkovic, D, Derks, TGJ, Bick, D, Bouman, K, Chatfield, KC, Damouny-Naoum, N, Dishop, MK, Falik-Zaccai, TC, Fares, F, Fedida, A, Ferrero, I, Gallagher, RC, Garesse, R , Gilberti, M, González, C , Gowan, K, Habib, C, Halligan, RK, Kalfon, L, Knight, K, Lefeber, D, Mamblona, L , Mandel, H, Mory, A, Ottoson, J, Paperna, T, Pruijn, GJM, Rebelo-Guiomar, PF, Saada, A, Sainz, B , Salvemini, H, Schoots, MH, Smeitink, JA, Szukszto, MJ, Ter Horst, HJ, van den Brandt, F, van Spronsen, FJ, Veltman, JA, Wartchow, E, Wintjes, LT, Zohar, Y, Fernández-Moreno, MA , Baris, HN, Donnini, C, Minczuk, M, Rodenburg, RJ, Van Hove, JLK. Nat Commun - 9 (1) : 4065 (PMID: 30283131) (doi:10.1038/s41467-018-06250-w)
15 nov | 2016 Human COA3 Is an Oligomeric Highly Flexible Protein in Solution. Neira, JL, Martínez-Rodríguez, S, Hernández-Cifre, JG, Cámara-Artigas, A, Clemente, P , Peralta, S , Fernández-Moreno, MÁ , Garesse, R , García de la Torre, J, Rizzuti, B. Biochemistry - 55 (45) : 6209-6220 (PMID: 27791355) (doi:10.1021/acs.biochem.6b00644)
19 ene | 2016 Functional Characterization of Three Concomitant MtDNA LHON Mutations Shows No Synergistic Effect on Mitochondrial Activity. Cruz-Bermúdez, A , Vicente-Blanco, RJ , Hernández-Sierra, R , Montero, M, Alvarez, J, González Manrique, M, Blázquez, A, Martín, MA, Ayuso, C, Garesse, R , Fernández-Moreno, MA . PLoS ONE - 11 (1) : e0146816 (PMID: 26784702) (doi:10.1371/journal.pone.0146816)
30 mayo | 2015 Enhanced tumorigenicity by mitochondrial DNA mild mutations. Cruz-Bermúdez, A , Vallejo, CG , Vicente-Blanco, RJ , Gallardo, ME , Fernández-Moreno, MÁ , Quintanilla, M , Garesse, R . Oncotarget - 6 (15) : 13628-13643 (PMID: 25909222) (doi:10.18632/oncotarget.3698)
1 mar | 2014 The pathogenicity scoring system for mitochondrial tRNA mutations revisited. González-Vioque, E , Bornstein, B , Gallardo, ME , Fernández-Moreno, MÁ , Garesse, R . Mol Genet Genomic Med - 2 (2) : 107-114 (PMID: 24689073) (doi:10.1002/mgg3.47)
1 oct | 2013 Drosophila nuclear factor DREF regulates the expression of the mitochondrial DNA helicase and mitochondrial transcription factor B2 but not the mitochondrial translation factor B1. Fernández-Moreno, MA , Hernández, R , Adán, C , Roberti, M, Bruni, F, Polosa, PL, Cantatore, P, Matsushima, Y, Kaguni, LS, Garesse, R . Biochim. Biophys. Acta - 1829 (10) : 1136-1146 (PMID: 23916463) (doi:10.1016/j.bbagrm.2013.07.006)
13 jul | 2012 Coiled coil domain-containing protein 56 (CCDC56) is a novel mitochondrial protein essential for cytochrome c oxidase function. Peralta, S , Clemente, P , Sánchez-Martínez, A , Calleja, M, Hernández-Sierra, R , Matsushima, Y, Adán, C , Ugalde, C, Fernández-Moreno, MÁ , Kaguni, LS, Garesse, R . J. Biol. Chem. - 287 (29) : 24174-24185 (PMID: 22610097) (doi:10.1074/jbc.M112.343764)
1 mar | 2009 The Drosophila nuclear factor DREF positively regulates the expression of the mitochondrial transcription termination factor DmTTF. Fernández-Moreno, MA , Bruni, F, Adán, C , Sierra, RH, Polosa, PL, Cantatore, P, Garesse, R , Roberti, M. Biochem. J. - 418 (2) : 453-462 (PMID: 19032147) (doi:10.1042/BJ20081174)
2 mayo | 2008 Mitochondrial transcription factor B2 is essential for metabolic function in Drosophila melanogaster development. Adán, C , Matsushima, Y, Hernández-Sierra, R , Marco-Ferreres, R , Fernández-Moreno, MA , González-Vioque, E , Calleja, M, Aragón, JJ , Kaguni, LS, Garesse, R . J. Biol. Chem. - 283 (18) : 12333-12342 (PMID: 18308726) (doi:10.1074/jbc.M801342200)
1 abr | 2007 Drosophila melanogaster as a model system to study mitochondrial biology. Fernández-Moreno, MA , Farr, CL, Kaguni, LS, Garesse, R . Methods Mol. Biol. - 372 : 33-49 (PMID: 18314716) (doi:10.1007/978-1-59745-365-3_3)
13 mayo | 2006 Modeling human mitochondrial diseases in flies. Sánchez-Martínez, A , Luo, N, Clemente, P , Adán, C , Hernández-Sierra, R , Ochoa, P , Fernández-Moreno, MA , Kaguni, LS, Garesse, R . Biochim. Biophys. Acta - 1757 (9-10) : 1190-1198 (PMID: 16806050) (doi:10.1016/j.bbabio.2006.05.008)
1 ene | 2006 Association of novel POLG mutations and multiple mitochondrial DNA deletions with variable clinical phenotypes in a Spanish population. González-Vioque, E , Blázquez, A, Fernández-Moreira, D, Bornstein, B , Bautista, J, Arpa, J, Navarro, C, Campos, Y, Fernández-Moreno, MA , Garesse, R , Arenas, J, Martín, MA. Arch Neurol - 63 (1) : 107-111 (PMID: 16401742) (doi:10.1001/archneur.63.1.107)
1 mayo | 2005 Comparative analysis of the pathogenic mechanisms associated with the G8363A and A8296G mutations in the mitochondrial tRNA(Lys) gene. Bornstein, B , Mas, JA, Patrono, C, Fernández-Moreno, MA , González-Vioque, E , Campos, Y, Carrozzo, R, Martín, MA, del Hoyo, P, Santorelli, FM, Arenas, J, Garesse, R . Biochem. J. - 387 (Pt 3) : 773-778 (PMID: 15554876) (doi:10.1042/BJ20040949)
13 oct | 2004 Expression of the Drosophila melanogaster ATP synthase alpha subunit gene is regulated by a transcriptional element containing GAF and Adf-1 binding sites. Talamillo, A, Fernández-Moreno, MA , Martínez-Azorín, F , Bornstein, B , Ochoa, P , Garesse, R . Eur. J. Biochem. - 271 (20) : 4003-4013 (PMID: 15479229) (doi:10.1111/j.1432-1033.2004.04336.x)
14 ene | 2003 Myoglobinuria and COX deficiency in a patient taking cerivastatin and gemfibrozil. Arenas, J, Fernández-Moreno, MA , Molina, JA, Fernández, V, del Hoyo, P, Campos, Y, Calvo, P, Martín, MA, García, A, Moreno, T, Martínez-Salio, A, Börnstein, B , Bermejo, F, Cabello, A, Garesse, R . Neurology - 60 (1) : 124-126 (PMID: 12525734)
21 mar | 2002 The A8296G mtDNA mutation associated with several mitochondrial diseases does not cause mitochondrial dysfunction in cybrid cell lines. Bornstein, B , Mas, JA , Fernández-Moreno, MA , Campos, Y, Martín, MA, del Hoyo, P, Rubio, JC, Arenas, J, Garesse, R . Hum. Mutat. - 19 (3) : 234-239 (PMID: 11857739) (doi:10.1002/humu.10050)
9 oct | 2001 Mitochondrial dysfunction associated with a mutation in the Notch3 gene in a CADASIL family. de la Peña, P, Bornstein, B , del Hoyo, P, Fernández-Moreno, MA , Martín, MA, Campos, Y, Gómez-Escalonilla, C, Molina, JA, Cabello, A, Arenas, J, Garesse, R . Neurology - 57 (7) : 1235-1238 (PMID: 11591842)
1 oct | 2001 Identification of a proximal promoter region critical for the expression of the beta-F1-ATPase gene during Drosophila melanogaster development. Ugalde, C, Ochoa, P , Pérez, ML, Fernández-Moreno, MA , Calleja, M, Alahari, A, Kaguni, LS, Garesse, R . Mitochondrion - 1 (3) : 225-236 (PMID: 16120280)
17 sep | 2001 Early-onset multisystem mitochondrial disorder caused by a nonsense mutation in the mitochondrial DNA cytochrome C oxidase II gene. Campos, Y, García-Redondo, A, Fernández-Moreno, MA , Martínez-Pardo, M, Goda, G, Rubio, JC, Martín, MA, del Hoyo, P, Cabello, A, Bornstein, B , Garesse, R , Arenas, J. Ann. Neurol. - 50 (3) : 409-413 (PMID: 11558799)
1 ene | 2001 Resolution of a mispaired secondary structure intermediate could account for a novel micro-insertion/deletion (387 insA/del 8 bp) in the PYGM gene causing McArdle's disease. Martín, MA, Rubio, JC, García, A, Fernández, MA , Campos, Y, Krawczak, M, Cooper, DN, Arenas, J. Clin. Genet. - 59 (1) : 48-51 (PMID: 11168025)
1 nov | 2000 The pathophysiology of mitochondrial biogenesis: towards four decades of mitochondrial DNA research. Fernández-Moreno, MA , Bornstein, B , Petit, N, Garesse, R . Mol. Genet. Metab. - 71 (3) : 481-495 (PMID: 11073716) (doi:10.1006/mgme.2000.3083)
20 oct | 2000 Differential regulation of the catalytic and accessory subunit genes of Drosophila mitochondrial DNA polymerase. Lefai, E , Fernandez-Moreno, MA , Alahari, A, Kaguni, LS, Garesse, R . J. Biol. Chem. - 275 (42) : 33123-33133 (PMID: 10930405) (doi:10.1074/jbc.M003024200)
1 jul | 2000 The pathogenic role of point mutations affecting the translational initiation codon of mitochondrial genes. Fernández-Moreno, MA , Bornstein, B , Campos, Y, Arenas, J, Garesse, R . Mol. Genet. Metab. - 70 (3) : 238-240 (PMID: 10924280) (doi:10.1006/mgme.2000.3005)
1 jun | 2000 The highly compact structure of the mitochondrial DNA polymerase genomic region of Drosophila melanogaster: functional and evolutionary implications. Lefai, E , Fernández-Moreno, MA , Kaguni, LS, Garesse, R . Insect Mol. Biol. - 9 (3) : 315-322 (PMID: 10886416)
24 dic | 1999 Structure and regulated expression of the delta-aminolevulinate synthase gene from Drosophila melanogaster. Ruiz de Mena, I, Fernández-Moreno, MA , Bornstein, B , Kaguni, LS, Garesse, R . J. Biol. Chem. - 274 (52) : 37321-37328 (PMID: 10601299)
1 nov | 1999 Characterization of the pathway-specific positive transcriptional regulator for actinorhodin biosynthesis in Streptomyces coelicolor A3(2) as a DNA-binding protein. Arias, P, Fernández-Moreno, MA , Malpartida, F. J. Bacteriol. - 181 (22) : 6958-6968 (PMID: 10559161)
1 jul | 1999 An additional regulatory gene for actinorhodin production in Streptomyces lividans involves a LysR-type transcriptional regulator. Martínez-Costa, OH, Martín-Triana, AJ, Martínez, E, Fernández-Moreno, MA , Malpartida, F. J. Bacteriol. - 181 (14) : 4353-4364 (PMID: 10400594)
1 ago | 1998 A silent ABC transporter isolated from Streptomyces rochei F20 induces multidrug resistance. Fernández-Moreno, MA , Carbó, L, Cuesta, T, Vallín, C, Malpartida, F. J. Bacteriol. - 180 (16) : 4017-4023 (PMID: 9696745)
1 ago | 1998 The relA/spoT-homologous gene in Streptomyces coelicolor encodes both ribosome-dependent (p)ppGpp-synthesizing and -degrading activities. Martínez-Costa, OH, Fernández-Moreno, MA , Malpartida, F. J. Bacteriol. - 180 (16) : 4123-4132 (PMID: 9696759)
1 nov | 1997 Streptothricin biosynthesis is catalyzed by enzymes related to nonribosomal peptide bond formation. Fernández-Moreno, MA , Vallín, C, Malpartida, F. J. Bacteriol. - 179 (22) : 6929-6936 (PMID: 9371436)
1 abr | 1996 Production of actinorhodin-related "blue pigments" by Streptomyces coelicolor A3(2). Bystrykh, LV, Fernández-Moreno, MA , Herrema, JK, Malpartida, F, Hopwood, DA, Dijkhuizen, L. J. Bacteriol. - 178 (8) : 2238-2244 (PMID: 8636024)
7 oct | 1994 DNA sequence and functions of the actVI region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3(2). Fernández-Moreno, MA , Martínez, E, Caballero, JL, Ichinose, K, Hopwood, DA, Malpartida, F. J. Biol. Chem. - 269 (40) : 24854-24863 (PMID: 7929165)
25 sep | 1992 Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin. Fernández-Moreno, MA , Martínez, E, Boto, L, Hopwood, DA, Malpartida, F. J. Biol. Chem. - 267 (27) : 19278-19290 (PMID: 1527048)
22 mayo | 1992 abaA, a new pleiotropic regulatory locus for antibiotic production in Streptomyces coelicolor. Fernández-Moreno, MA , Martín-Triana, AJ, Martínez, E, Niemi, J, Kieser, HM, Hopwood, DA, Malpartida, F. J. Bacteriol. - 174 (9) : 2958-2967 (PMID: 1569025)
23 ago | 1991 The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of Streptomyces. Fernández-Moreno, MA , Caballero, JL, Hopwood, DA, Malpartida, F. Cell - 66 (4) : 769-780 (PMID: 1878971)