18 abr | 2024 Clinical mutations in the TERT and TERC genes coding for telomerase components induced oxidative stress, DNA damage at telomeres and cell apoptosis besides decreased telomerase activity. Fernández-Varas, B , Manguan-García, C , Rodriguez-Centeno, J , Mendoza-Lupiáñez, L , Calatayud, J, Perona, R , Martín-Martínez, M, Gutierrez-Rodriguez, M, Benítez-Buelga, C , Sastre, L . Hum Mol Genet - 33 (9) : 818-834 (PMID: 38641551) (doi:10.1093/hmg/ddae015)
17 abr | 2024 ΔNp73 and its effector targets promote colorectal peritoneal carcinosis and predict survival. Pastor-Morate, D , Amigo-Morán, L , Garranzo-Asensio, M, Rejas-González, R, Carnicero, P , Rodríguez, N, Pérez-Robledo, JP, Barderas, R, Prieto-Nieto, I, Domínguez, G . J Pathol (PMID: 38629257) (doi:10.1002/path.6286)
11 abr | 2024 A murine model for the del(GJB6-D13S1830) deletion recapitulating the phenotype of human DFNB1 hearing impairment: generation and functional and histopathological study. Domínguez-Ruiz, M, Murillo-Cuesta, S , Contreras, J , Cantero, M, Garrido, G, Martín-Bernardo, B, Gómez-Rosas, E, Fernández, A, Del Castillo, FJ, Montoliu, L, Varela-Nieto, I , Del Castillo, I. BMC Genomics - 25 (1) : 359 (PMID: 38605287) (doi:10.1186/s12864-024-10289-z)
30 mar | 2024 Biomarkers of NRF2 signalling: Current status and future challenges. Morgenstern, C, Lastres-Becker, I , Demirdöğen, BC, Costa, VM, Daiber, A, Foresti, R, Motterlini, R, Kalyoncu, S, Arioz, BI, Genc, S, Jakubowska, M, Trougakos, IP, Piechota-Polanczyk, A, Mickael, M, Santos, M, Kensler, TW, Cuadrado, A , Copple, IM. Redox Biol - 72 : 103134 (PMID: 38643749) (doi:10.1016/j.redox.2024.103134)
28 mar | 2024 Reprogramming of the LXRα Transcriptome Sustains Macrophage Secondary Inflammatory Responses. Vladimir de la Rosa, J, Tabraue, C, Huang, Z, Orizaola, MC , Martin-Rodríguez, P, Steffensen, KR, Zapata, JM , Boscá, L , Tontonoz, P, Alemany, S , Treuter, E, Castrillo, A . Adv Sci (Weinh) (PMID: 38549193) (doi:10.1002/advs.202307201)
26 mar | 2024 Variant characterisation and clinical profile in a large cohort of patients with Ellis-van Creveld syndrome and a family with Weyers acrofacial dysostosis. Altunoglu, U, Palencia-Campos, A , Güneş, N, Turgut, GT, Nevado, J, Lapunzina, P, Valencia, M , Iturrate, A , Otaify, G, Elhossini, R, Ashour, A, K Amin, A, Elnahas, RF, Fernandez-Nuñez, E , Flores, CL , Arias, P, Tenorio, J, Chamorro Fernández, CI, Güven, Y, Özsu, E, Eklioğlu, BS, Ibarra-Ramirez, M, Diness, BR, Burnyte, B, Ajmi, H, Yüksel, Z, Yıldırım, R, Ünal, E, Abdalla, E, Aglan, M, Kayserili, H, Tuysuz, B, Ruiz-Pérez, V . J Med Genet (PMID: 38531627) (doi:10.1136/jmg-2023-109546)
23 mar | 2024 Intraoperative assessment of cochlear nerve functionality in various vestibular schwannoma scenarios: Lessons learned. Lassaletta, L , Calvino, M, Díaz, M, Morales-Puebla, JM, Sánchez-Cuadrado, I, Varela-Nieto, I , Gavilán, J. Hear Res - 446 : 108997 (PMID: 38564963) (doi:10.1016/j.heares.2024.108997)
22 mar | 2024 Platinum iodido drugs show potential anti-tumor activity, affecting cancer cell metabolism and inducing ROS and senescence in gastrointestinal cancer cells. Melones-Herrero, J , Alcalá, S , Ruiz-Cañas, L , Benítez-Buelga, C , Batres-Ramos, S , Calés, C , Lorenzo, O, Perona, R , Quiroga, AG, Sainz, B , Sánchez-Pérez, I . Commun Biol - 7 (1) : 353 (PMID: 38519773) (doi:10.1038/s42003-024-06052-5)
22 mar | 2024 Prostate fibroblasts and prostate cancer associated fibroblasts exhibit different metabolic, matrix degradation and PD-L1 expression responses to hypoxia. Pacheco-Torres, J , Sharma, RK, Mironchik, Y, Wildes, F, Brennen, WN, Artemov, D, Krishnamachary, B, Bhujwalla, ZM. Front Mol Biosci - 11 : 1354076 (PMID: 38584702) (doi:10.3389/fmolb.2024.1354076)
19 mar | 2024 BEHAV3D: a 3D live imaging platform for comprehensive analysis of engineered T cell behavior and tumor response. Alieva, M , Barrera Román, M, de Blank, S, Petcu, D, Zeeman, AL, Dautzenberg, NMM, Cornel, AM, van de Ven, C, Pieters, R, den Boer, ML, Nierkens, S, Calkoen, FGJ, Clevers, H, Kuball, J, Sebestyén, Z, Wehrens, EJ, Dekkers, JF, Rios, AC. Nat Protoc (PMID: 38504137) (doi:10.1038/s41596-024-00972-6)
19 mar | 2024 Biomarkers in Contrast-Induced Acute Kidney Injury: Towards A New Perspective. González-Nicolás, MÁ, González-Guerrero, C, Goicoechea, M, Boscá, L , Valiño-Rivas, L, Lázaro, A. Int J Mol Sci - 25 (6) (PMID: 38542410) (doi:10.3390/ijms25063438)
7 mar | 2024 Inhibition of glycogen synthase kinase-3 enhances NRF2 protein stability, nuclear localisation and target gene transcription in pancreatic beta cells. Patibandla, C, van Aalten, L, Dinkova-Kostova, AT, Honda, T, Cuadrado, A , Fernández-Ginés, R , McNeilly, AD, Hayes, JD, Cantley, J, Sutherland, C. Redox Biol - 71 : 103117 (PMID: 38479223) (doi:10.1016/j.redox.2024.103117)
7 mar | 2024 Thyroid hormone action in adult neurogliogenic niches: the known and unknown. Valcárcel-Hernández, V, Mayerl, S, Guadaño-Ferraz, A , Remaud, S. Front Endocrinol (Lausanne) - 15 : 1347802 (PMID: 38516412) (doi:10.3389/fendo.2024.1347802)
4 mar | 2024 Autophagy sustains mitochondrial respiration and determines resistance to BRAFV600E inhibition in thyroid carcinoma cells. Díaz-Gago, S, Vicente-Gutiérrez, J, Ruiz-Rodríguez, JM, Calafell, J, Álvarez-Álvarez, A, Lasa, M , Chiloeches, A, Baquero, P. Autophagy (PMID: 38436206) (doi:10.1080/15548627.2024.2312790)
3 mar | 2024 Cardiolipin Membranes Promote Cytochrome c Transformation of Polycyclic Aromatic Hydrocarbons and Their In Vivo Metabolites. Lopes, J, Marques-da-Silva, D, Videira, PA, Samhan-Arias, AK , Lagoa, R. Molecules - 29 (5) (PMID: 38474641) (doi:10.3390/molecules29051129)
15 feb | 2024 Inhibition of ALK3-mediated signalling pathway protects against acetaminophen-induced liver injury. Marañón, P, Rey, E, Isaza, SC, Wu, H, Rada, P , Choya-Foces, C, Martínez-Ruiz, A, Martín, MÁ, Ramos, S, García-Monzón, C, Cubero, FJ, Valverde, ÁM , González-Rodríguez, Á . Redox Biol - 71 : 103088 (PMID: 38401290) (doi:10.1016/j.redox.2024.103088)
15 feb | 2024 TPX2 overexpression promotes sensitivity to dasatinib in breast cancer by activating YAP transcriptional signaling. Marugán, C, Sanz-Gómez, N , Ortigosa, B , Monfort-Vengut, A , Bertinetti, C , Teijo, A, González, M , Alonso de la Vega, A, Lallena, MJ, Moreno-Bueno, G , de Cárcer, G . Mol Oncol (PMID: 38357786) (doi:10.1002/1878-0261.13602)
14 feb | 2024 Expanding the genetic and phenotypic spectrum of congenital myasthenic syndrome: new homozygous VAMP1 splicing variants in 2 novel individuals. Cotrina-Vinagre, FJ, Rodríguez-García, ME, Del Pozo-Filíu, L, Hernández-Laín, A, Arteche-López, A, Morte, B , Sevilla, M, Pérez-Jurado, LA, Quijada-Fraile, P, Camacho, A, Martínez-Azorín, F . J Hum Genet (PMID: 38355957) (doi:10.1038/s10038-024-01228-7)
10 feb | 2024 Clinical practice guideline on the management of vestibular schwannoma. Lassaletta, L , Acle Cervera, L, Altuna, X, Amilibia Cabeza, E, Arístegui Ruiz, M, Batuecas Caletrio, Á, Benítez Del Rosario, J, Cabanillas Farpón, R, Costales Marcos, M, Escada, P, Espinosa-Sánchez, JM, García Leal, R, Gavilán, J, Gómez Martínez, J, González-Aguado, R, Martinez-Glez, V, Guerra Jiménez, G, Harguindey Antolí-Candela, A, Hernández García, BJ, Orús Dotú, C, Polo López, R, Manrique, M, Martín Sanz, E, Martínez Álvarez, R, Martínez, H, Martínez-Martínez, M, Rey-Martinez, J, Ropero Romero, F, Santa Cruz Ruiz, S, Vallejo, LÁ, Soto Varela, A, Varela-Nieto, I , Morales Puebla, JM. Acta Otorrinolaringol Esp (Engl Ed) (PMID: 38346489) (doi:10.1016/j.otoeng.2023.10.005)
5 feb | 2024 Fever-like temperature impacts on Staphylococcus aureus and Pseudomonas aeruginosa interaction, physiology, and virulence both in vitro and in vivo. Solar Venero, EC , Galeano, MB, Luqman, A, Ricardi, MM, Serral, F, Fernandez Do Porto, D, Robaldi, SA, Ashari, BAZ, Munif, TH, Egoburo, DE, Nemirovsky, S, Escalante, J, Nishimura, B, Ramirez, MS, Götz, F, Tribelli, PM. BMC Biol - 22 (1) : 27 (PMID: 38317219) (doi:10.1186/s12915-024-01830-3)
2 feb | 2024 Intestinal Effects of Filtered Alkalinized Water in Lean and Obese Zucker Rats. Doblado, L , Díaz, LE, Nova, E, Marcos, A, Monsalve, M . Microorganisms - 12 (2) (PMID: 38399722) (doi:10.3390/microorganisms12020316)
2 feb | 2024 β-cell Jagged1 is sufficient but not necessary for islet Notch activity and insulin secretory defects in obese mice. Suda, N, Bartolomé, A , Liang, J, Son, J, Yagishita, Y, Siebel, C, Accili, D, Ding, H, Pajvani, UB. Mol Metab (PMID: 38311286) (doi:10.1016/j.molmet.2024.101894)
1 feb | 2024 Contribution of Nucleotide-Binding Oligomerization Domain-like (NOD) Receptors to the Immune and Metabolic Health. Apaza, CJ, Días, M, García Tejedor, A, Boscá, L , Laparra Llopis, JM. Biomedicines - 12 (2) (PMID: 38397943) (doi:10.3390/biomedicines12020341)
1 feb | 2024 Hospital-based screening outperforms primary care screening as a means of achieving hepatitis C virus micro-elimination. Fernández-García, CE, Gallego-Galiana, J, Solís-Muñoz, PA, Del Pozo-Maroto, E, Domínguez-Alcón, L, Tobar-Izquierdo, M, Sáez, A, Rodríguez de Cía, J, Magaña-Sánchez, A, Real-Martínez, Y, García-Buey, L, González-Moreno, L, Caldas-Álvarez, M, Cardeñoso-Domingo, LM, González-Gamarra, A, Salvador-Calvo, A, González-Rodríguez, Á , García-Monzón, C. Infect Dis Now (PMID: 38309646) (doi:10.1016/j.idnow.2024.104855)
1 feb | 2024 Insights on the role of thyroid hormone transport in neurosensory organs and implication for Allan-Herndon-Dudley syndrome. García-Aldea, Á , Guillén-Yunta, M , Valcárcel-Hernández, V , Montero-Pedrazuela, A , Guadaño-Ferraz, A , Bárez-López, S . Eur Thyroid J (PMID: 38417253) (doi:10.1530/ETJ-23-0241)
31 ene | 2024 An altered expression of miR-376a-3p and miR-20a-5p in peripheral blood exosomes regulates the autophagy and inflammatory systemic substrates, and relates to the smoking habit and age in Crohn's disease. Caparrós, E, García-Martinez, I , Pedro Zapater, , Lucía Madero, , Valverde, ÁM , Ana Gutiérrez, , Francés, R. FASEB J - 38 (2) : e23418 (PMID: 38226870) (doi:10.1096/fj.202301761R)
29 ene | 2024 Routing of Kv7.1 to endoplasmic reticulum plasma membrane junctions. Serrano-Novillo, C, Estadella, I, Navarro-Pérez, M, Oliveras, A, de Benito-Bueno, A , Socuéllamos, PG , Bosch, M, Coronado, MJ, Sastre, D, Valenzuela, C , Soeller, C, Felipe, A . Acta Physiol (Oxf) (PMID: 38282556) (doi:10.1111/apha.14106)
27 ene | 2024 Targeting cancer stem cell OXPHOS with tailored ruthenium complexes as a new anti-cancer strategy. Alcalá, S , Villarino, L, Ruiz-Cañas, L , Couceiro, JR, Martínez-Calvo, M, Palencia-Campos, A , Navarro, D , Cabezas-Sainz, P, Rodriguez-Arabaolaza, I , Cordero-Barreal, A , Trilla-Fuertes, L, Rubiolo, JA, Batres-Ramos, S , Vallespinos, M , González-Páramos, C , Rodríguez, J, Gámez-Pozo, A , Vara, JÁF, Fernández, SF, Berlinches, AB, Moreno-Mata, N, Redondo, AMT, Carrato, A, Hermann, PC, Sánchez, L, Torrente, S, Fernández-Moreno, MÁ , Mascareñas, JL, Sainz, B . J Exp Clin Cancer Res - 43 (1) : 33 (PMID: 38281027) (doi:10.1186/s13046-023-02931-7)
23 ene | 2024 HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling. Terri, M, Sandoval, P, Bontempi, G, Montaldo, C, Tomero-Sanz, H, de Turris, V, Trionfetti, F, Pascual-Antón, L, Clares-Pedrero, I, Battistelli, C, Valente, S, Zwergel, C, Mai, A, Rosanò, L, Del Pozo, MÁ, Sánchez-Álvarez, M , Cabañas, C, Tripodi, M, López-Cabrera, M, Strippoli, R. J Exp Clin Cancer Res - 43 (1) : 27 (PMID: 38254102) (doi:10.1186/s13046-023-02930-8)
17 ene | 2024 Synergistic Effect of a Flavonoid-Rich Cocoa-Carob Blend and Metformin in Preserving Pancreatic Beta Cells in Zucker Diabetic Fatty Rats. Gallardo-Villanueva, P, Fernández-Marcelo, T, Villamayor, L , Valverde, AM , Ramos, S, Fernández-Millán, E, Martín, MA. Nutrients - 16 (2) (PMID: 38257166) (doi:10.3390/nu16020273)
16 ene | 2024 HuR (ELAVL1) Stabilizes SOX9 mRNA and Promotes Migration and Invasion in Breast Cancer Cells. Morillo-Bernal, J , Pizarro-García, P , Moreno-Bueno, G , Cano, A , Mazón, MJ , Eraso, P , Portillo, F . Cancers (Basel) - 16 (2) (PMID: 38254873) (doi:10.3390/cancers16020384)
10 ene | 2024 Cardiometabolic Changes in Sirtuin1-Heterozygous Mice on High-Fat Diet and Melatonin Supplementation. Favero, G, Golic, I, Arnaboldi, F, Cappella, A, Korac, A, Monsalve, M , Stacchiotti, A, Rezzani, R. Int J Mol Sci - 25 (2) (PMID: 38255934) (doi:10.3390/ijms25020860)
9 ene | 2024 Trabectedin and Lurbinectedin Modulate the Interplay between Cells in the Tumour Microenvironment-Progresses in Their Use in Combined Cancer Therapy. Povo-Retana, A , Landauro-Vera, R , Alvarez-Lucena, C , Cascante, M, Boscá, L . Molecules - 29 (2) (PMID: 38257245) (doi:10.3390/molecules29020331)
6 ene | 2024 Fatty acid amide hydrolase drives adult mammary gland development by promoting luminal cell differentiation. Tundidor, I, Seijo-Vila, M, Blasco-Benito, S, Rubert-Hernández, M, Moreno-Bueno, G , Bindila, L, de la Rosa, RF, Guzmán, M, Sánchez, C, Pérez-Gómez, E . Cell Death Discov - 10 (1) : 12 (PMID: 38184644) (doi:10.1038/s41420-023-01788-1)
3 ene | 2024 GDF15 activates AMPK and inhibits gluconeogenesis and fibrosis in the liver by attenuating the TGF-β1/SMAD3 pathway. Jurado-Aguilar, J, Barroso, E, Bernard, M, Zhang, M, Peyman, M, Rada, P , Valverde, ÁM , Wahli, W, Palomer, X, Vázquez-Carrera, M. Metabolism - 152 : 155772 (PMID: 38176644) (doi:10.1016/j.metabol.2023.155772)
3 ene | 2024 Specific targeting of the NRF2/β-TrCP axis promotes beneficial effects in NASH. Fernández-Ginés, R , Encinar, JA, Escoll, M , Carnicero-Senabre, D , Jiménez-Villegas, J , García-Yagüe, ÁJ , González-Rodríguez, Á , Garcia-Martinez, I , M Valverde, Á , Rojo, AI , Cuadrado, A . Redox Biol - 69 : 103027 (PMID: 38184999) (doi:10.1016/j.redox.2024.103027)