3 Dec | 2024 The CDK12-BRCA1 signaling axis mediates dinaciclib-associated radiosensitivity through p53-mediated cellular senescence. Flores, NG, Fernández-Aroca, DM, Garnés-García, C, Domínguez-Calvo, A, Jiménez-Suárez, J, Sabater, S, Fernández-Aroca, P, Andrés, I, Cimas, FJ, de Cárcer, G , Belandia, B , Palmero, I , Huertas, P, Ruiz-Hidalgo, MJ, Sánchez-Prieto, R . Mol Oncol (PMID: 39626031) (doi:10.1002/1878-0261.13773)
28 Nov | 2024 Plasma membrane remodeling determines adipocyte expansion and mechanical adaptability. Aboy-Pardal, MCM, Guadamillas, MC, Guerrero, CR, Català-Montoro, M, Toledano-Donado, M, Terrés-Domínguez, S, Pavón, DM, Jiménez-Jiménez, V, Jimenez-Carretero, D, Zamai, M, Folgueira, C, Cerezo, A, Lolo, FN, Nogueiras, R, Sabio, G, Sánchez-Álvarez, M , Echarri, A, Garcia, R, Del Pozo, MA. Nat Commun - 15 (1) : 10102 (PMID: 39609408) (doi:10.1038/s41467-024-54224-y)
28 Nov | 2024 The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk. Valdecantos, MP , Ruiz, L , Folgueira, C, Rada, P , Gomez-Santos, B, Solas, M, Hitos, AB , Field, J, Francisco, V , Escalona-Garrido, C , Zagmutt, S, Calderon-Dominguez, M, Mera, P, Garcia-Martinez, I , Maymó-Masip, E, Grajales, D , Alen, R , Mora, A, Sáinz, N, Vides-Urrestarazu, I, Vilarrasa, N, Arbones-Mainar, JM, Zaragoza, C, Moreno-Aliaga, MJ, Aspichueta, P, Fernández-Veledo, S, Vendrell, J, Serra, D, Herrero, L, Schreiber, R, Zechner, R, Sabio, G, Hornigold, D, Rondinone, CM, Jermutus, L, Grimsby, J, Valverde, ÁM . Nat Commun - 15 (1) : 10342 (PMID: 39609390) (doi:10.1038/s41467-024-54080-w)
27 Nov | 2024 NRF2 activation by 6-MSITC increases the generation of neuroprotective, soluble α amyloid precursor protein by inducing the metalloprotease gene ADAM17. Carnicero-Senabre, D , Jiménez-Villegas, J , Álvarez-Garrote, S, Escoll, M , Cuadrado, A , Rojo, AI . Free Radic Biol Med (PMID: 39613049) (doi:10.1016/j.freeradbiomed.2024.11.048)
21 Nov | 2024 Role of the transcription factor NRF2 in maintaining the integrity of the Blood-Brain Barrier. Cazalla, E, Cuadrado, A , García-Yagüe, ÁJ . Fluids Barriers CNS - 21 (1) : 93 (PMID: 39574123) (doi:10.1186/s12987-024-00599-5)
6 Nov | 2024 Immunometabolic Effect of Nitric Oxide on Human Macrophages Challenged With the SARS-CoV2-Induced Cytokine Storm. A Fluxomic Approach. Sánchez-García, S , Povo-Retana, A , Marin, S, Madurga, S, Fariñas, M, Aleixandre, N, Castrillo, A , de la Rosa, JV, Alvarez-Lucena, C , Landauro-Vera, R , Prieto, P , Cascante, M, Boscá, L . Adv Healthc Mater (PMID: 39502019) (doi:10.1002/adhm.202401688)
1 Nov | 2024 Investigation in the cannabigerol derivative VCE-003.2 as a disease-modifying agent in a mouse model of experimental synucleinopathy. Burgaz, S, Navarro, E, Rodríguez-Carreiro, S, Navarrete, C, Garrido-Rodríguez, M, Lastres-Becker, I , Chocarro, J, Lanciego, JL, Muñoz, E, Fernández-Ruiz, J. Behav Brain Funct - 20 (1) : 28 (PMID: 39487447) (doi:10.1186/s12993-024-00256-9)
31 Oct | 2024 Formin-like 1β phosphorylation at S1086 is necessary for secretory polarized traffic of exosomes at the immune synapse in Jurkat T lymphocytes. Ruiz-Navarro, J , Fernández-Hermira, S , Sanz-Fernández, I , Barbeito, P , Navarro-Zapata, A, Pérez-Martínez, A, Garcia-Gonzalo, FR , Calvo, V , Izquierdo Pastor, M . Elife - 13 (PMID: 39479958) (doi:10.7554/eLife.96942)
29 Oct | 2024 Immunological and molecular features of the tumor microenvironment of long-term survivors of ovarian cancer. Nelson, BH, Hamilton, PT, Phung, MT, Milne, K, Harris, B, Thornton, S, Stevens, DL, Kalaria, S, Singh, K, Laumont, CM, Moss, E, Alimujiang, A, Meagher, NS, Bolithon, A, Fereday, S, Kennedy, CJ, Hendley, J, Ariyaratne, D, Alsop, K, Traficante, N, Goode, EL, Karnezis, AN, Shen, H, Richardson, J, McKinnon Deurloo, C, Chase, A, Grout, B, Doherty, JA, Harris, HR, Cushing-Haugen, KL, Anglesio, MS, Heinze, K, Huntsman, D, Talhouk, A, Hanley, GE, Alsop, J, Jimenez-Linan, M, Pharoah, PD, Boros, J, Brand, AH, Harnett, PR, Sharma, R, Hecht, JL, Sasamoto, N, Terry, KL, Karlan, BY, Lester, J, Carney, ME, Goodman, MT, Hernandez, BY, Wilkens, LR, Behrens, S, Turzanski Fortner, R, Fasching, PA, Bisinotto, C, Candido Dos Reis, FJ, Ghatage, P, Köbel, M, Elishaev, E, Modugno, F, Cook, LS, Le, ND, Gentry-Maharaj, A, Menon, U, García, MJ , Rodriguez-Antona, C , Farrington, KM, Kelemen, LE, Kommoss, S, Staebler, A, Garsed, DW, Brenton, JD, Piskorz, AM, Bowtell, DD, DeFazio, A, Ramus, SJ, Pike, MC, Pearce, CL. J Clin Invest (PMID: 39470729) (doi:10.1172/JCI179501)
28 Oct | 2024 Molecular mapping of KCNE4-dependent regulation of Kv1.3. Sastre, D, Colomer-Molera, M, Roig, SR, de Benito-Bueno, A , Socuellamos, PG , Fernandez-Ballester, G, Valenzuela, C , Felipe, A . Am J Physiol Cell Physiol (PMID: 39466181) (doi:10.1152/ajpcell.00499.2024)
26 Oct | 2024 Potential Beneficial Role of Nitric Oxide in SARS-CoV-2 Infection: Beyond Spike-Binding Inhibition. Sánchez-García, S , Castrillo, A , Boscá, L , Prieto, P . Antioxidants (Basel) - 13 (11) (PMID: 39594443) (doi:10.3390/antiox13111301)
23 Oct | 2024 A select thiosemicarbazone copper(II) complex induces apoptosis in gastric cancer and targets cancer stem cells reducing pluripotency markers. Fabra, D, Melones-Herrero, J , Velazquez-Gutierrez, J, Matesanz, AI, Aliseda, PD, Figueiras, S, Aguilar-Rico, F, Calés, C , Sánchez-Pérez, I , Quiroga, AG. Eur J Med Chem - 280 : 116994 (PMID: 39489985) (doi:10.1016/j.ejmech.2024.116994)
18 Oct | 2024 Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis. Ardanaz, CG, de la Cruz, A, Minhas, PS, Hernández-Martín, N, Pozo, MÁ, Valdecantos, MP , Valverde, ÁM , Villa-Valverde, P, Elizalde-Horcada, M, Puerta, E, Ramírez, MJ, Ortega, JE, Urbiola, A, Ederra, C, Ariz, M, Ortiz-de-Solórzano, C, Fernández-Irigoyen, J, Santamaría, E, Karsenty, G, Brüning, JC, Solas, M. Sci Adv - 10 (42) : eadp1115 (PMID: 39423276) (doi:10.1126/sciadv.adp1115)
16 Oct | 2024 Aripiprazole, but Not Olanzapine, Alters the Response to Oxidative Stress in Fao Cells by Reducing the Activation of Mitogen-Activated Protein Kinases (MAPKs) and Promoting Cell Survival. Kramar, B, Pirc Marolt, T, Yilmaz Goler, AM, Šuput, D, Milisav, I, Monsalve, M . Int J Mol Sci - 25 (20) (PMID: 39456900) (doi:10.3390/ijms252011119)
16 Oct | 2024 Genetic characteristics of clinical carbapenem-resistant Klebsiella pneumoniae: epidemic ST11 KPC-2-producing strains and non-negligible NDM-5-producing strains with diverse STs. Yuan, Y, Lu, Y, Cao, L, Fu, Y, Li, Y, Zhang, L. Sci Rep - 14 (1) : 24296 (PMID: 39414846) (doi:10.1038/s41598-024-74307-6)
16 Oct | 2024 Two distinct epithelial-to-mesenchymal transition programs control invasion and inflammation in segregated tumor cell populations. Youssef, KK, Narwade, N, Arcas, A, Marquez-Galera, A, Jiménez-Castaño, R, Lopez-Blau, C, Fazilaty, H, García-Gutierrez, D, Cano, A , Galcerán, J, Moreno-Bueno, G , Lopez-Atalaya, JP, Nieto, MA. Nat Cancer (PMID: 39414946) (doi:10.1038/s43018-024-00839-5)
15 Oct | 2024 Pipolins are bimodular platforms that maintain a reservoir of defense systems exchangeable with various bacterial genetic mobile elements. Mateo-Cáceres, V , Redrejo-Rodríguez, M . Nucleic Acids Res (PMID: 39404074) (doi:10.1093/nar/gkae891)
12 Oct | 2024 Protein Kinase D2 modulates hepatic insulin sensitivity in male mice. Rada, P , Carceller-López, E , Hitos, AB , Gómez-Santos, B, Fernández-Hernández, C, Rey, E, Pose-Utrilla, J , García-Monzón, C, González-Rodríguez, Á , Sabio, G, García, A, Aspichueta, P, Iglesias, T , Valverde, ÁM . Mol Metab (PMID: 39401614) (doi:10.1016/j.molmet.2024.102045)
7 Oct | 2024 SIRT1 Mediates the Antagonism of Wnt/β-Catenin Pathway by Vitamin D in Colon Carcinoma Cells. García-Martínez, JM , Chocarro-Calvo, A , Martínez-Useros, J, Regueira-Acebedo, N, Fernández-Aceñero, MJ, Muñoz, A , Larriba, MJ , García-Jiménez, C. Int J Biol Sci - 20 (14) : 5495-5509 (PMID: 39494323) (doi:10.7150/ijbs.95875)
4 Oct | 2024 Retrospective study assessing the role of the androgen receptor in clear cell renal cell cancer patients treated with VEGFR inhibitors in monotherapy. Osorio, L, Grazioso, TP, de Velasco, G, Etxaniz, O, Pérez-Gracia, JL, Pinto, Á, Durán, I, Grande, E, Garcia, PB, Lázaro, M, Rodriguez, L, Villalobos, ML, García, L, Cuellar, A, Solís-Hernández, MP, Pernaut, C, Rodríguez-Moreno, JF, Rodriguez-Antona, C , García-Donas, J. Clin Transl Oncol (PMID: 39365364) (doi:10.1007/s12094-024-03652-9)
3 Oct | 2024 Editorial: Structure and function of the immunological and redirecting artificial synapses and their clinical implications. Izquierdo, M , Ruiz-Navarro, J , Baldari, CT, Roda-Navarro, P. Front Immunol - 15 : 1497118 (PMID: 39421740) (doi:10.3389/fimmu.2024.1497118)
25 Sep | 2024 IMMUNE AND MOLECULAR CORRELATES OF RESPONSE TO IMMUNOTHERAPY REVEALED BY BRAIN-METASTATIC MELANOMA MODELS. Daugherty-Lopès, A, Pérez-Guijarro, E , Gopalan, V, Rappaport, J, Chen, Q, Huang, A, Lam, KC, Chin, S, Ebersole, J, Wu, E, Needle, GA, Church, I, Kyriakopoulos, G, Xie, S, Zhao, Y, Gruen, C, Sassano, A, Araya, RE, Thorkelsson, A, Smith, C, Lee, MP, Hannenhalli, S, Day, CP, Merlino, G, Goldszmid, RS. bioRxiv (PMID: 39372744) (doi:10.1101/2024.08.26.609785)
24 Sep | 2024 Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntington's disease. Chakraborty, A, Sreenivasmurthy, SG, Miller, W, Huai, W, Biswas, T, Mandal, SM, Boscá, L , Krishnan, B, Ghosh, G, Hazra, T. Proc Natl Acad Sci U S A - 121 (39) : e2406308121 (PMID: 39298485) (doi:10.1073/pnas.2406308121)
23 Sep | 2024 Creating a path during melanoma amoeboid migration: When too crowded, start worrying. Orgaz, JL . Dev Cell - 59 (18) : 2395-2397 (PMID: 39317164) (doi:10.1016/j.devcel.2024.07.009)
23 Sep | 2024 Editorial: Community series in mouse models of B cell malignancies, volume II. Perez-Chacon, G , Vincent-Fabert, C, Zapata, JM . Front Immunol - 15 : 1488601 (PMID: 39376568) (doi:10.3389/fimmu.2024.1488601)
20 Sep | 2024 Role of cfDNA and ctDNA to improve the risk stratification and the disease follow-up in patients with endometrial cancer: towards the clinical application. Casas-Arozamena, C, Vilar, A, Cueva, J, Arias, E, Sampayo, V, Diaz, E, Oltra, SS , Moiola, CP, Cabrera, S, Cortegoso, A, Curiel, T, Abalo, A, Pamies Serrano, M, Domingo, S, Padilla-Iserte, P, Arnaez de la Cruz, M, Hernández, A, García-Pineda, V, Ruiz-Bañobre, J, López, R, Matias-Guiu, X, Colás, E, Gil-Moreno, A, Abal, M, Moreno-Bueno, G , Muinelo-Romay, L. J Exp Clin Cancer Res - 43 (1) : 264 (PMID: 39304963) (doi:10.1186/s13046-024-03158-w)
13 Sep | 2024 Histologic and Molecular Type Changes in Endometrial Cancer Recurrences in Comparison With Their Corresponding Primary Tumors. Moreno-Moreno, E, Caniego-Casas, T, Carretero-Barrio, I, Cortés, A, Muriel, A, Domínguez-Rullán, JA, Martín-Gromaz, C, Moreno-Bueno, G , Matías-Guiu, X, Palacios, J, Pérez-Mies, B. Am J Surg Pathol (PMID: 39269025) (doi:10.1097/PAS.0000000000002308)
4 Sep | 2024 HyperTraPS-CT: Inference and prediction for accumulation pathways with flexible data and model structures. Aga, ONL, Brun, M, Dauda, KA, Diaz-Uriarte, R , Giannakis, K, Johnston, IG. PLoS Comput Biol - 20 (9) : e1012393 (PMID: 39231165) (doi:10.1371/journal.pcbi.1012393)
3 Sep | 2024 Autofluorescent Cancer Stem Cells: Potential Biomarker to Predict Recurrence in Resected Colorectal Tumor. Alcala, S , Serralta San Martin, G, Muñoz-Fernández de Legaria, M, Moreno-Rubio, J, Salinas, S, López-Gil, JC , Rojo López, JA, Martínez Alegre, J, Cortes Bandy, DA, Zambrana, F, Jiménez-Gordo, AM, Casado, E , López-Gómez, M, Sainz, B . Cancer Res Commun (PMID: 39225547) (doi:10.1158/2767-9764.CRC-24-0188)
2 Sep | 2024 Beneficial Effect of Dimethyl Fumarate Drug Repositioning in a Mouse Model of TDP-43-Dependent Frontotemporal Dementia. Silva-Llanes, I , Martín-Baquero, R, Berrojo-Armisen, A, Rodríguez-Cueto, C, Fernández-Ruiz, J, De Lago, E, Lastres-Becker, I . Antioxidants (Basel) - 13 (9) (PMID: 39334731) (doi:10.3390/antiox13091072)
29 Aug | 2024 MAML3-fusions modulate vascular and immune tumour microenvironment and confer high metastatic risk in pheochromocytoma and paraganglioma. Monteagudo, M, Calsina, B, Salazar-Hidalgo, ME, Martínez-Montes, ÁM, Piñeiro-Yáñez, E, Caleiras, E, Martín, MC, Rodríguez-Perales, S, Letón, R, Gil, E, Buffet, A, Burnichon, N, Fernández-Sanromán, Á, Díaz-Talavera, A, Mellid, S, Arroba, E, Reglero, C, Martínez-Puente, N, Roncador, G, Del Olmo, MI, Corrales, PJP, Oliveira, CL, Álvarez-Escolá, C, Gutiérrez, MC, López-Fernández, A, García, NP, Regojo, RM, Díaz, LR, Laorden, NR, Guadarrama, OS, Bechmann, N, Beuschlein, F, Canu, L, Eisenhofer, G, Fassnacht, M, Nölting, S, Quinkler, M, Rapizzi, E, Remde, H, Timmers, HJ, Favier, J, Gimenez-Roqueplo, AP, Rodriguez-Antona, C , Currás-Freixes, M, Al-Shahrour, F, Cascón, A, Leandro-García, LJ, Montero-Conde, C , Robledo, M. Best Pract Res Clin Endocrinol Metab (PMID: 39218714) (doi:10.1016/j.beem.2024.101931)
27 Aug | 2024 Non-immune hydrops fetalis is associated with bi-allelic pathogenic variants in the MYB Binding Protein 1a (MYBBP1A) gene. Tenorio-Castano, J, Mansilla Aparicio, E, García Santiago, FA, Klotz, CM, Regojo, RM, Anguita, E , Ryan, E, Juusola, J, Herrero, B, Arias, P, Parra, A, Pascual, P, Gallego, N, Cazalla, M, Rodriguez-González, R, Antolín, E, Nevado, J , Ruiz-Perez, VL , Lapunzina, P. Clin Genet (PMID: 39191491) (doi:10.1111/cge.14601)
16 Aug | 2024 PPARβ/δ attenuates hepatic fibrosis by reducing SMAD3 phosphorylation and p300 levels via AMPK in hepatic stellate cells. Zhang, M, Barroso, E, Peña, L, Rada, P , Valverde, ÁM , Wahli, W, Palomer, X, Vázquez-Carrera, M. Biomed Pharmacother - 179 : 117303 (PMID: 39153437) (doi:10.1016/j.biopha.2024.117303)
15 Aug | 2024 Modulation of the K/BxN arthritis mouse model and the effector functions of human fibroblast-like synoviocytes by liver X receptors. Domínguez-Luis, MJ, Castro-Hernández, J, Santos-Concepción, S, Díaz-Martín, A, Arce-Franco, M, Pérez-González, N, Díaz, M, Castrillo, A , Salido, E, Machado, JD, Gumá, M, Corr, M, Díaz-González, F. Eur J Immunol (PMID: 39148175) (doi:10.1002/eji.202451136)
13 Aug | 2024 PharmVar GeneFocus: CYP4F2. Zubiaur, P, Rodríguez-Antona, C , Boone, EC, Daly, AK, Tsermpini, EE, Khasawneh, LQ, Sangkuhl, K, Duconge, J, Botton, MR, Savieo, J, Nofziger, C, Whirl-Carrillo, M, Klein, TE, Gaedigk, A. Clin Pharmacol Ther (PMID: 39135485) (doi:10.1002/cpt.3405)
12 Aug | 2024 Alx3 deficiency disrupts energy homeostasis, alters body composition, and impairs hypothalamic regulation of food intake. Mirasierra, M , Fernández-Pérez, A , Lizarbe, B , Keiran, N, Ruiz-Cañas, L , Casarejos, MJ, Cerdán, S , Vendrell, J, Fernández-Veledo, S, Vallejo, M . Cell Mol Life Sci - 81 (1) : 343 (PMID: 39129011) (doi:10.1007/s00018-024-05384-z)
10 Aug | 2024 Discovery of a potent melatonin-based inhibitor of quinone reductase-2 with neuroprotective and neurogenic properties. Herrera-Arozamena, C, Estrada-Valencia, M, García-Díez, G, Pérez, C , León, R, Infantes, L, Morales-García, JA , Pérez-Castillo, A , Del Sastre, E, López, MG, Rodríguez-Franco, MI. Eur J Med Chem - 277 : 116763 (PMID: 39146834) (doi:10.1016/j.ejmech.2024.116763)
1 Aug | 2024 Defective thyroid hormone transport to the brain leads to astroglial alterations. Guillén-Yunta, M , García-Aldea, Á , Valcárcel-Hernández, V , Sanz-Bógalo, A , Muñoz-Moreno, E, Matheus, MG, Grijota-Martínez, C , Montero-Pedrazuela, A , Guadaño-Ferraz, A , Bárez-López, S . Neurobiol Dis (PMID: 39097035) (doi:10.1016/j.nbd.2024.106621)
27 Jul | 2024 Glutathione overproduction mediates lymphoma initiating cells survival and has a sex-dependent effect on lymphomagenesis. H-Alcántara, A, Kourani, O , Marcos-Jiménez, A, Martínez-Núñez, P, Herranz-Martín, E, Fuentes, P, Toribio, ML, Muñoz-Calleja, C, Iglesias, T , Campanero, MR . Cell Death Dis - 15 (7) : 534 (PMID: 39068166) (doi:10.1038/s41419-024-06923-z)
20 Jul | 2024 Culture of Bovine Aortic Endothelial Cells in Galactose Media Enhances Mitochondrial Plasticity and Changes Redox Sensing, Altering Nrf2 and FOXO3 Levels. Galant, LS , Doblado, L , Radi, R, de Bem, AF, Monsalve, M . Antioxidants (Basel) - 13 (7) (PMID: 39061940) (doi:10.3390/antiox13070873)
18 Jul | 2024 Refining the phenotype of SINO syndrome: A comprehensive cohort report of 14 novel cases. Alstrup, M, Cesca, F, Krawczun-Rygmaczewska, A, López-Menéndez, C , Pose-Utrilla, J , Castberg, FC, Bjerager, MO, Finnila, C, Kruer, MC, Bakhtiari, S, Padilla-Lopez, S, Manwaring, L, Keren, B, Afenjar, A, Galatolo, D, Scalise, R, Santorelli, FM, Shillington, A, Vezain, M, Martinovic, J, Stevens, C, Gowda, VK, Srinivasan, VM, Thiffault, I, Pastinen, T, Baranano, K, Lee, A, Granadillo, J, Glassford, MR, Keegan, CE, Matthews, N, Saugier-Veber, P, Iglesias, T , Østergaard, E. Genet Med (PMID: 39033379) (doi:10.1016/j.gim.2024.101219)
15 Jul | 2024 Trans-[Pt(amine)Cl2(PPh3)] Complexes Target Mitochondria and Endoplasmic Reticulum in Gastric Cancer Cells. Melones-Herrero, J , Delgado-Aliseda, P , Figueiras, S , Velázquez-Gutiérrez, J , Quiroga, AG, Calés, C , Sánchez-Pérez, I . Int J Mol Sci - 25 (14) (PMID: 39062981) (doi:10.3390/ijms25147739)
12 Jul | 2024 Bhlhe40 Regulates Proliferation and Angiogenesis in Mouse Embryoid Bodies under Hypoxia. Acosta-Iborra, B , Gil-Acero, AI , Sanz-Gómez, M , Berrouayel, Y , Puente-Santamaría, L , Alieva, M , Del Peso, L , Jiménez, B . Int J Mol Sci - 25 (14) (PMID: 39062912) (doi:10.3390/ijms25147669)
6 Jul | 2024 Endogenous LXR signaling controls pulmonary surfactant homeostasis and prevents lung inflammation. Hernández-Hernández, I, De La Rosa, JV, Martín-Rodríguez, P, Díaz-Sarmiento, M, Recio, C, Guerra, B, Fernández-Pérez, L, León, TE, Torres, R, Font-Díaz, J, Roig, A, de Mora, F, Boscá, L , Díaz, M, Valledor, AF, Castrillo, A , Tabraue, C. Cell Mol Life Sci - 81 (1) : 287 (PMID: 38970705) (doi:10.1007/s00018-024-05310-3)
5 Jul | 2024 SARS-CoV-2 S Protein Reduces Cytoprotective Defenses and Promotes Human Endothelial Cell Senescence. Villacampa, A, Shamoon, L, Valencia, I, Morales, C, Figueiras, S , la Cuesta, F, Sánchez-Niño, D, Díaz-Araya, G, Sánchez-Pérez, I , Lorenzo, Ó, Sánchez-Ferrer, CF, Peiró, C. Aging Dis (PMID: 39012668) (doi:10.14336/AD.2024.0405)
2 Jul | 2024 Methods to Assess Autophagic Activity in Dictyostelium. Antón-Esteban, L , Tornero-Écija, A , Vincent, O , Escalante, R . Methods Mol Biol - 2814 : 97-9106 (PMID: 38954200) (doi:10.1007/978-1-0716-3894-1_7)
1 Jul | 2024 DUSP1 and SOX2 expression determine squamous cell carcinoma of the salivary gland progression. Acero-Riaguas, L , Griso-Acevedo, AB, SanLorenzo-Vaquero, A, Ibáñez-Herrera, B, Fernandez-Diaz, SM, Mascaraque, M, Sánchez-Siles, R, López-García, I, Benítez-Buelga, C , Bravo-Burguillos, ER, Castelo, B, Cebrián-Carretero, JL, Perona, R , Sastre, L , Sastre-Perona, A . Sci Rep - 14 (1) : 15007 (PMID: 38951654) (doi:10.1038/s41598-024-65945-x)
28 Jun | 2024 May I Help You with Your Coat? HIV-1 Capsid Uncoating and Reverse Transcription. Arribas, L, Menéndez-Arias, L, Betancor, G. Int J Mol Sci - 25 (13) (PMID: 39000271) (doi:10.3390/ijms25137167)
28 Jun | 2024 Potential protective role of let-7d-5p in atherosclerosis progression reducing the inflammatory pathway regulated by NF-κB and vascular smooth muscle cells proliferation. Aroca-Esteban, J, Souza-Neto, FV, Aguilar-Latorre, C, Tribaldo-Torralbo, A, González-López, P, Ruiz-Simón, R, Álvarez-Villareal, M, Ballesteros, S, de Ceniga, MV, Landete, P, González-Rodríguez, Á , Martín-Ventura, JL, de Las Heras, N, Escribano, Ó, Gómez-Hernández, A. Biochim Biophys Acta Mol Basis Dis (PMID: 38945455) (doi:10.1016/j.bbadis.2024.167327)
27 Jun | 2024 Percutaneous pulmonary thrombectomy with aspiration catheters in patients with high-risk pulmonary embolism and absolute contraindication to systemic thrombolysis. Tébar, D, Jurado-Román, A, Jiménez-Valero, S, Galeote, G, Gonzálvez, A, Rivero, B, García, A, Añón Elizalde, JM, Lorenzo, A, Fernández Capitán, C, Torres, R, Soto, C, Alcolea, S, Rosillo, S, Caro Codón, J, Arbas, E, Tejera, F, Plaza, I, Boscá, L , Moreno, R. Cardiovasc Revasc Med (PMID: 38960828) (doi:10.1016/j.carrev.2024.06.020)
27 Jun | 2024 Tumor-Intrinsic Perinuclear LOXL2: Prognostic Relevance and Relationship with YAP1 Activation Status in Oral Squamous Cell Carcinoma. Rodrigo, JP, Moreno-Bueno, G , Lequerica-Fernández, P, Rodríguez-Santamarta, T, Díaz, E, Prieto-Fernández, L, Álvarez-Teijeiro, S, García-Pedrero, JM, de Vicente, JC. Pathobiology (PMID: 38934185) (doi:10.1159/000539928)
18 Jun | 2024 Combined deletion of Mct8 and Dio2 impairs SVZ neurogliogenesis and olfactory function in adult mice. Valcárcel-Hernández, V , Vancamp, P, Butruille, L, Remaud, S, Guadaño-Ferraz, A . Neurobiol Dis (PMID: 38901782) (doi:10.1016/j.nbd.2024.106572)
18 Jun | 2024 Fibroblast growth factor 21 is a hepatokine involved in MASLD progression. Gallego-Durán, R, Ampuero, J, Maya-Miles, D, Pastor-Ramírez, H, Montero-Vallejo, R, Rivera-Esteban, J, Álvarez-Amor, L, Pareja, MJ, Rico, MC, Millán, R, Robles-Frías, MJ, Aller, R, Rojas, Á, Muñoz-Hernández, R, Gil-Gómez, A, Gato, S, García-Lozano, M, Arias-Loste, MT, Abad, J, Calleja, JL, Andrade, RJ, Crespo, J, González-Rodríguez, Á , García-Monzón, C, Andreola, F, Pericás, JM, Jalan, R, Martín-Bermudo, F, Romero-Gómez, M. United European Gastroenterol J (PMID: 38894596) (doi:10.1002/ueg2.12534)
17 Jun | 2024 Cardiac Metabolism. Martin-Puig, S , Menendez-Montes, I. Adv Exp Med Biol - 1441 : 365-396 (PMID: 38884721) (doi:10.1007/978-3-031-44087-8_19)
14 Jun | 2024 KCNE4-dependent modulation of Kv1.3 pharmacology. Sastre, D, Colomer-Molera, M, de Benito-Bueno, A , Valenzuela, C , Fernández-Ballester, G, Felipe, A . Biochem Pharmacol (PMID: 38880360) (doi:10.1016/j.bcp.2024.116368)
14 Jun | 2024 The hepatocyte epidermal growth factor receptor (EGFR) pathway regulates the cellular interactome within the liver fibrotic niche. Gonzalez-Sanchez, E, Vaquero, J, Caballero-Diaz, D, Grzelak, J, Fusté, NP, Bertran, E, Amengual, J, Garcia-Saez, J, Martín-Mur, B, Gut, M, Esteve-Codina, A, Alay, A, Coulouarn, C, Calero-Perez, S, Valdecantos, P , Valverde, AM , Sánchez, A, Herrera, B, Fabregat, I. J Pathol (PMID: 38872438) (doi:10.1002/path.6299)
14 Jun | 2024 Three-dimensional environment sensitizes pancreatic cancer cells to the anti-proliferative effect of budesonide by reprogramming energy metabolism. Ibello, E, Saracino, F, Delle Cave, D, Buonaiuto, S, Amoroso, F, Andolfi, G, Corona, M, Guardiola, O, Colonna, V, Sainz, B , Altucci, L, De Cesare, D, Cobellis, G, Lonardo, E, Patriarca, EJ, D'Aniello, C, Minchiotti, G. J Exp Clin Cancer Res - 43 (1) : 165 (PMID: 38877560) (doi:10.1186/s13046-024-03072-1)
7 Jun | 2024 Beneficial effects of hepatic cyclooxygenase-2 expression against cholestatic injury after common bile duct ligation in mice. Brea, R , Casanova, N , Alvarez-Lucena, C , Fuertes-Agudo, M, Luque-Tevar, M, Cucarella, C, Capitani, MC, Marinochi, MV, Fusini, ME, Lahoz, A, Nogueroles, ML, Fraile, J , Ronco, MT, Boscá, L , González-Rodríguez, Á , García-Monzón, C, Martín-Sanz, P , Casado, M, Francés, DE . Liver Int (PMID: 38847511) (doi:10.1111/liv.16004)
6 Jun | 2024 Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions. Dareng, EO, Coetzee, SG, Tyrer, JP, Peng, PC, Rosenow, W, Chen, S, Davis, BD, Dezem, FS, Seo, JH, Nameki, R, Reyes, AL, Aben, KKH, Anton-Culver, H, Antonenkova, NN, Aravantinos, G, Bandera, EV, Beane Freeman, LE, Beckmann, MW, Beeghly-Fadiel, A, Benitez, J, Bernardini, MQ, Bjorge, L, Black, A, Bogdanova, NV, Bolton, KL, Brenton, JD, Budzilowska, A, Butzow, R, Cai, H, Campbell, I, Cannioto, R, Chang-Claude, J, Chanock, SJ, Chen, K, Chenevix-Trench, G, , , Chiew, YE, Cook, LS, DeFazio, A, Dennis, J, Doherty, JA, Dörk, T, du Bois, A, Dürst, M, Eccles, DM, Ene, G, Fasching, PA, Flanagan, JM, Fortner, RT, Fostira, F, Gentry-Maharaj, A, Giles, GG, Goodman, MT, Gronwald, J, Haiman, CA, Håkansson, N, Heitz, F, Hildebrandt, MAT, Høgdall, E, Høgdall, CK, Huang, RY, Jensen, A, Jones, ME, Kang, D, Karlan, BY, Karnezis, AN, Kelemen, LE, Kennedy, CJ, Khusnutdinova, EK, Kiemeney, LA, Kjaer, SK, Kupryjanczyk, J, Labrie, M, Lambrechts, D, Larson, MC, Le, ND, Lester, J, Li, L, Lubiński, J, Lush, M, Marks, JR, Matsuo, K, May, T, McLaughlin, JR, McNeish, IA, Menon, U, Missmer, S, Modugno, F, Moffitt, M, Monteiro, AN, Moysich, KB, Narod, SA, Nguyen-Dumont, T, Odunsi, K, Olsson, H, Onland-Moret, NC, Park, SK, Pejovic, T, Permuth, JB, Piskorz, A, Prokofyeva, D, Riggan, MJ, Risch, HA, Rodríguez-Antona, C , Rossing, MA, Sandler, DP, Setiawan, VW, Shan, K, Song, H, Southey, MC, Steed, H, Sutphen, R, Swerdlow, AJ, Teo, SH, Terry, KL, Thompson, PJ, Vestrheim Thomsen, LC, Titus, L, Trabert, B, Travis, R, Tworoger, SS, Valen, E, Van Nieuwenhuysen, E, Edwards, DV, Vierkant, RA, Webb, PM, , , Weinberg, CR, Weise, RM, Wentzensen, N, White, E, Winham, SJ, Wolk, A, Woo, YL, Wu, AH, Yan, L, Yannoukakos, D, Zeinomar, N, Zheng, W, Ziogas, A, Berchuck, A, Goode, EL, Huntsman, DG, Pearce, CL, Ramus, SJ, Sellers, TA, , , Freedman, ML, Lawrenson, K, Schildkraut, JM, Hazelett, D, Plummer, JT, Kar, S, Jones, MR, Pharoah, PDP, Gayther, SA. Am J Hum Genet - 111 (6) : 1061-1083 (PMID: 38723632) (doi:10.1016/j.ajhg.2024.04.011)
5 Jun | 2024 Periodic table screening for enhanced positive contrast in MRI and in vivo uptake in glioblastoma. Herraiz, A, Morales, MP, Martínez-Parra, L, Arias-Ramos, N , López-Larrubia, P , Gutiérrez, L, Mejías, J, Díaz-Ufano, C, Ruiz-Cabello, J, Herranz, F. Chem Sci - 15 (22) : 8578-8590 (PMID: 38846405) (doi:10.1039/d4sc01069h)
3 Jun | 2024 A multispectral 3D live organoid imaging platform to screen probes for fluorescence guided surgery. Jeremiasse, B, van Ineveld, RL, Bok, V, Kleinnijenhuis, M, de Blank, S, Alieva, M , Johnson, HR, van Vliet, EJ, Zeeman, AL, Wellens, LM, Llibre-Palomar, G, Barrera Román, M, Di Maggio, A, Dekkers, JF, Oliveira, S, Vahrmeijer, AL, Molenaar, JJ, Wijnen, MH, van der Steeg, AF, Wehrens, EJ, Rios, AC. EMBO Mol Med (PMID: 38831131) (doi:10.1038/s44321-024-00084-4)
29 May | 2024 A Novel Missense Variant in the NKX2-1 Homeodomain Prevents Transcriptional Rescue by TAZ. Villafuerte, B, Carrasco-López, C , Herranz, A, Garzón, L, Simón, R, Natera-de-Benito, D, Alikhani, P, Tenorio, J, García-Santiago, F, Solis, M, Del-Pozo, Á, Lapunzina, P, Ortigoza-Escobar, JD, Santisteban, P , Moreno, JC. Thyroid (PMID: 38757609) (doi:10.1089/thy.2023.0593)
24 May | 2024 Molecular pathways in mitochondrial disorders due to a defective mitochondrial protein synthesis. Antolínez-Fernández, Á , Esteban-Ramos, P , Fernández-Moreno, MÁ , Clemente, P . Front Cell Dev Biol - 12 : 1410245 (PMID: 38855161) (doi:10.3389/fcell.2024.1410245)
22 May | 2024 Advances in the Development of New Drugs and Treatment Targets for Brain Cancers. Ibarra, LE, Milla Sanabria, LN, Arias-Ramos, N . Brain Sci - 14 (6) (PMID: 38928527) (doi:10.3390/brainsci14060526)
18 May | 2024 Evaluation of the clinical use of MGMT methylation in extracellular vesicle-based liquid biopsy as a tool for glioblastoma patient management. Rosas-Alonso, R, Colmenarejo-Fernández, J, Pernía, O, Burdiel, M, Rodríguez-Antolín, C, Losantos-García, I, Rubio, T, Moreno-Velasco, R, Esteban-Rodríguez, I, Martínez-Marín, V, Yubero, P, Costa-Fraga, N, Díaz-Lagares, A, López-López, R, Díaz-Martin, E, García, JF, Sánchez, CV, Gandía-González, ML, Moreno-Bueno, G , de Castro, J, de Cáceres, II. Sci Rep - 14 (1) : 11398 (PMID: 38762534) (doi:10.1038/s41598-024-62061-8)
16 May | 2024 The Peptidoglycan Recognition Protein 1 confers immune evasive properties on pancreatic cancer stem cells. López-Gil, JC , García-Silva, S , Ruiz-Cañas, L , Navarro, D , Palencia-Campos, A , Giráldez-Trujillo, A, Earl, J, Dorado, J , Gómez-López, G, Monfort-Vengut, A , Alcalá, S , Gaida, MM, García-Mulero, S, Cabezas-Sáinz, P, Batres-Ramos, S , Barreto, E, Sánchez-Tomero, P , Vallespinós, M, Ambler, L, Lin, ML, Aicher, A, García García de Paredes, A, de la Pinta, C, Sanjuanbenito, A, Ruz-Caracuel, I, Rodríguez-Garrote, M, Guerra, C, Carrato, A, de Cárcer, G , Sánchez, L, Nombela-Arrieta, C, Espinet, E, Sanchez-Arevalo Lobo, VJ, Heeschen, C, Sainz, B . Gut (PMID: 38754953) (doi:10.1136/gutjnl-2023-330995)
10 May | 2024 Estrogens prevent the hypothalamus-periphery crosstalk induced by olanzapine intraperitoneal treatment in female mice: Effects on brown/beige adipose tissues and liver. Ferreira, V , Folgueira, C, Montes-San Lorenzo, Á , Rodríguez-López, A, Gonzalez-Iglesias, E, Zubiaur, P, Abad-Santos, F, Sabio, G, Rada, P , Valverde, ÁM . Biochim Biophys Acta Mol Basis Dis - 1870 (5) : 167227 (PMID: 38733774) (doi:10.1016/j.bbadis.2024.167227)
8 May | 2024 Newer generations of multi-target CAR and STAb-T immunotherapeutics: NEXT CART Consortium as a cooperative effort to overcome current limitations. Martín-Antonio, B, Blanco, B, González-Murillo, Á, Hidalgo, L, Minguillón, J, Pérez-Chacón, G , , , , . Front Immunol - 15 : 1386856 (PMID: 38779672) (doi:10.3389/fimmu.2024.1386856)
7 May | 2024 CDH1 methylation analysis in invasive lobular breast carcinomas with and without gene mutation. González-Martínez, S, Kajabova, VH, Pérez-Mies, B, Carretero-Barrio, I, Caniego-Casas, T, Sarrió, D , Moreno-Bueno, G , Gión, M, Perez-García, J, Cortés, J, Smolkova, B, Palacios, J. Virchows Arch (PMID: 38713384) (doi:10.1007/s00428-024-03814-8)
3 May | 2024 Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer. Haderk, F, Chou, YT, Cech, L, Fernández-Méndez, C , Yu, J, Olivas, V, Meraz, IM, Barbosa Rabago, D, Kerr, DL, Gomez, C, Allegakoen, DV, Guan, J, Shah, KN, Herrington, KA, Gbenedio, OM, Nanjo, S, Majidi, M, Tamaki, W, Pourmoghadam, YK, Rotow, JK, McCoach, CE, Riess, JW, Gutkind, JS, Tang, TT, Post, L, Huang, B, Santisteban, P , Goodarzi, H, Bandyopadhyay, S, Kuo, CJ, Roose, JP, Wu, W, Blakely, CM, Roth, JA, Bivona, TG. Nat Commun - 15 (1) : 3741 (PMID: 38702301) (doi:10.1038/s41467-024-47423-0)
1 May | 2024 Experience with the ACURATE neo and neo2 transcatheter aortic valves in Spain. The PRECISA (PRospective Evaluation Complementing Investigation with ACURATE devices) registry. Tébar, D, Carrillo, X, García Del Blanco, B, Gómez-Hospital, JA, Nombela, L, Molina, E, Galeote, G, Vilalta, V, Serra-García, V, Carol, GM, Jiménez-Valero, S, Fernandez-Nofrerias, E, Calabuig-Goena, Á, Jurado-Román, A, Sánchez-Recalde, Á, Velasco, MF, Bosca, L , Moreno, R. Catheter Cardiovasc Interv - 103 (6) : 1015-1022 (PMID: 38577931) (doi:10.1002/ccd.31032)
29 Apr | 2024 Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids. Bustamante-Madrid, P , Barbáchano, A , Albandea-Rodríguez, D , Rodríguez-Cobos, J , Rodríguez-Salas, N, Prieto, I, Burgos, A, Martínez de Villarreal, J, Real, FX, González-Sancho, JM , Larriba, MJ , Lafarga, M, Muñoz, A , Fernández-Barral, A . Cell Death Dis - 15 (4) : 301 (PMID: 38684650) (doi:10.1038/s41419-024-06680-z)
28 Apr | 2024 Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma. Mahmood, M, Liu, EM, Shergold, AL, Tolla, E, Tait-Mulder, J, Huerta-Uribe, A, Shokry, E, Young, AL, Lilla, S, Kim, M, Park, T, Boscenco, S, Manchon, JL, Rodríguez-Antona, C , Walters, RC, Springett, RJ, Blaza, JN, Mitchell, L, Blyth, K, Zanivan, S, Sumpton, D, Roberts, EW, Reznik, E, Gammage, PA. Nat Cancer - 5 (4) : 659-672 (PMID: 38286828) (doi:10.1038/s43018-023-00721-w)
23 Apr | 2024 Integrative Magnetic Resonance Imaging and Metabolomic Characterization of a Glioblastoma Rat Model. Arias-Ramos, N , Vieira, C , Pérez-Carro, R , López-Larrubia, P . Brain Sci - 14 (5) (PMID: 38790388) (doi:10.3390/brainsci14050409)
21 Apr | 2024 Tumors of the nervous system and hearing loss: Beyond vestibular schwannomas. Ruiz-García, C , Lassaletta, L , López-Larrubia, P , Varela-Nieto, I , Murillo-Cuesta, S . Hear Res - 447 : 109012 (PMID: 38703433) (doi:10.1016/j.heares.2024.109012)
20 Apr | 2024 Stochastic modelling of single-cell gene expression adaptation reveals non-genomic contribution to evolution of tumor subclones. Hirsch, MG, Pal, S, Mehrabadi, FR, Malikic, S, Gruen, C, Sassano, A, Pérez-Guijarro, E , Merlino, G, Sahinalp, C, Molloy, EK, Day, CP, Przytycka, TM. bioRxiv (PMID: 38712152) (doi:10.1101/2024.04.17.588869)
18 Apr | 2024 Clinical mutations in the TERT and TERC genes coding for telomerase components induced oxidative stress, DNA damage at telomeres and cell apoptosis besides decreased telomerase activity. Fernández-Varas, B , Manguan-García, C , Rodriguez-Centeno, J , Mendoza-Lupiáñez, L , Calatayud, J, Perona, R , Martín-Martínez, M, Gutierrez-Rodriguez, M, Benítez-Buelga, C , Sastre, L . Hum Mol Genet - 33 (9) : 818-834 (PMID: 38641551) (doi:10.1093/hmg/ddae015)
17 Apr | 2024 ΔNp73 and its effector targets promote colorectal peritoneal carcinosis and predict survival. Pastor-Morate, D , Amigo-Morán, L , Garranzo-Asensio, M, Rejas-González, R, Carnicero, P , Rodríguez, N, Pérez-Robledo, JP, Barderas, R, Prieto-Nieto, I, Domínguez, G . J Pathol (PMID: 38629257) (doi:10.1002/path.6286)
11 Apr | 2024 A murine model for the del(GJB6-D13S1830) deletion recapitulating the phenotype of human DFNB1 hearing impairment: generation and functional and histopathological study. Domínguez-Ruiz, M, Murillo-Cuesta, S , Contreras, J , Cantero, M, Garrido, G, Martín-Bernardo, B, Gómez-Rosas, E, Fernández, A, Del Castillo, FJ, Montoliu, L, Varela-Nieto, I , Del Castillo, I. BMC Genomics - 25 (1) : 359 (PMID: 38605287) (doi:10.1186/s12864-024-10289-z)
8 Apr | 2024 Uncovering a Novel Functional Interaction Between Adult Hepatic Progenitor Cells, Inflammation and EGFR Signaling During Bile Acids-Induced Injury. García-Sáez, J, Figueroa-Fuentes, M, González-Corralejo, C, Roncero, C, Lazcanoiturburu, N, Gutiérrez-Uzquiza, Á, Vaquero, J, González-Sánchez, E, Bhutia, K, Calero-Pérez, S , Maina, F, Traba, J, Valverde, ÁM , Fabregat, I, Herrera, B, Sánchez, A. Int J Biol Sci - 20 (7) : 2339-2355 (PMID: 38725853) (doi:10.7150/ijbs.90645)
30 Mar | 2024 Biomarkers of NRF2 signalling: Current status and future challenges. Morgenstern, C, Lastres-Becker, I , Demirdöğen, BC, Costa, VM, Daiber, A, Foresti, R, Motterlini, R, Kalyoncu, S, Arioz, BI, Genc, S, Jakubowska, M, Trougakos, IP, Piechota-Polanczyk, A, Mickael, M, Santos, M, Kensler, TW, Cuadrado, A , Copple, IM. Redox Biol - 72 : 103134 (PMID: 38643749) (doi:10.1016/j.redox.2024.103134)
28 Mar | 2024 Reprogramming of the LXRα Transcriptome Sustains Macrophage Secondary Inflammatory Responses. Vladimir de la Rosa, J, Tabraue, C, Huang, Z, Orizaola, MC , Martin-Rodríguez, P, Steffensen, KR, Zapata, JM , Boscá, L , Tontonoz, P, Alemany, S , Treuter, E, Castrillo, A . Adv Sci (Weinh) (PMID: 38549193) (doi:10.1002/advs.202307201)
26 Mar | 2024 Variant characterisation and clinical profile in a large cohort of patients with Ellis-van Creveld syndrome and a family with Weyers acrofacial dysostosis. Altunoglu, U, Palencia-Campos, A , Güneş, N, Turgut, GT, Nevado, J, Lapunzina, P, Valencia, M , Iturrate, A , Otaify, G, Elhossini, R, Ashour, A, K Amin, A, Elnahas, RF, Fernandez-Nuñez, E , Flores, CL , Arias, P, Tenorio, J, Chamorro Fernández, CI, Güven, Y, Özsu, E, Eklioğlu, BS, Ibarra-Ramirez, M, Diness, BR, Burnyte, B, Ajmi, H, Yüksel, Z, Yıldırım, R, Ünal, E, Abdalla, E, Aglan, M, Kayserili, H, Tuysuz, B, Ruiz-Pérez, V . J Med Genet (PMID: 38531627) (doi:10.1136/jmg-2023-109546)
23 Mar | 2024 Intraoperative assessment of cochlear nerve functionality in various vestibular schwannoma scenarios: Lessons learned. Lassaletta, L , Calvino, M, Díaz, M, Morales-Puebla, JM, Sánchez-Cuadrado, I, Varela-Nieto, I , Gavilán, J. Hear Res - 446 : 108997 (PMID: 38564963) (doi:10.1016/j.heares.2024.108997)
22 Mar | 2024 Platinum iodido drugs show potential anti-tumor activity, affecting cancer cell metabolism and inducing ROS and senescence in gastrointestinal cancer cells. Melones-Herrero, J , Alcalá, S , Ruiz-Cañas, L , Benítez-Buelga, C , Batres-Ramos, S , Calés, C , Lorenzo, O, Perona, R , Quiroga, AG, Sainz, B , Sánchez-Pérez, I . Commun Biol - 7 (1) : 353 (PMID: 38519773) (doi:10.1038/s42003-024-06052-5)
22 Mar | 2024 Prostate fibroblasts and prostate cancer associated fibroblasts exhibit different metabolic, matrix degradation and PD-L1 expression responses to hypoxia. Pacheco-Torres, J , Sharma, RK, Mironchik, Y, Wildes, F, Brennen, WN, Artemov, D, Krishnamachary, B, Bhujwalla, ZM. Front Mol Biosci - 11 : 1354076 (PMID: 38584702) (doi:10.3389/fmolb.2024.1354076)
19 Mar | 2024 BEHAV3D: a 3D live imaging platform for comprehensive analysis of engineered T cell behavior and tumor response. Alieva, M , Barrera Román, M, de Blank, S, Petcu, D, Zeeman, AL, Dautzenberg, NMM, Cornel, AM, van de Ven, C, Pieters, R, den Boer, ML, Nierkens, S, Calkoen, FGJ, Clevers, H, Kuball, J, Sebestyén, Z, Wehrens, EJ, Dekkers, JF, Rios, AC. Nat Protoc (PMID: 38504137) (doi:10.1038/s41596-024-00972-6)
19 Mar | 2024 Biomarkers in Contrast-Induced Acute Kidney Injury: Towards A New Perspective. González-Nicolás, MÁ, González-Guerrero, C, Goicoechea, M, Boscá, L , Valiño-Rivas, L, Lázaro, A. Int J Mol Sci - 25 (6) (PMID: 38542410) (doi:10.3390/ijms25063438)
7 Mar | 2024 Inhibition of glycogen synthase kinase-3 enhances NRF2 protein stability, nuclear localisation and target gene transcription in pancreatic beta cells. Patibandla, C, van Aalten, L, Dinkova-Kostova, AT, Honda, T, Cuadrado, A , Fernández-Ginés, R , McNeilly, AD, Hayes, JD, Cantley, J, Sutherland, C. Redox Biol - 71 : 103117 (PMID: 38479223) (doi:10.1016/j.redox.2024.103117)
7 Mar | 2024 Thyroid hormone action in adult neurogliogenic niches: the known and unknown. Valcárcel-Hernández, V, Mayerl, S, Guadaño-Ferraz, A , Remaud, S. Front Endocrinol (Lausanne) - 15 : 1347802 (PMID: 38516412) (doi:10.3389/fendo.2024.1347802)
5 Mar | 2024 Genome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease. Ramachandran, D, Tyrer, JP, Kommoss, S, DeFazio, A, Riggan, MJ, , , Webb, PM, Fasching, PA, Lambrechts, D, García, MJ , Rodríguez-Antona, C , Goodman, MT, Modugno, F, Moysich, KB, Karlan, BY, Lester, J, Kjaer, SK, Jensen, A, Høgdall, E, Goode, EL, Cliby, WA, Kumar, A, Wang, C, Cunningham, JM, Winham, SJ, Monteiro, AN, Schildkraut, JM, Cramer, DW, Terry, KL, Titus, L, Bjorge, L, Thomsen, LCV, , , Pejovic, T, Høgdall, CK, McNeish, IA, May, T, Huntsman, DG, Pfisterer, J, Canzler, U, Park-Simon, TW, Schröder, W, Belau, A, Hanker, L, Harter, P, Sehouli, J, Kimmig, R, de Gregorio, N, Schmalfeldt, B, Baumann, K, Hilpert, F, Burges, A, Winterhoff, B, Schürmann, P, Speith, LM, Hillemanns, P, Berchuck, A, Johnatty, SE, Ramus, SJ, Chenevix-Trench, G, Pharoah, PDP, Dörk, T, Heitz, F. NPJ Genom Med - 9 (1) : 19 (PMID: 38443389) (doi:10.1038/s41525-024-00395-y)
4 Mar | 2024 Autophagy sustains mitochondrial respiration and determines resistance to BRAFV600E inhibition in thyroid carcinoma cells. Díaz-Gago, S, Vicente-Gutiérrez, J, Ruiz-Rodríguez, JM, Calafell, J, Álvarez-Álvarez, A, Lasa, M , Chiloeches, A, Baquero, P. Autophagy (PMID: 38436206) (doi:10.1080/15548627.2024.2312790)
3 Mar | 2024 Cardiolipin Membranes Promote Cytochrome c Transformation of Polycyclic Aromatic Hydrocarbons and Their In Vivo Metabolites. Lopes, J, Marques-da-Silva, D, Videira, PA, Samhan-Arias, AK , Lagoa, R. Molecules - 29 (5) (PMID: 38474641) (doi:10.3390/molecules29051129)
15 Feb | 2024 Inhibition of ALK3-mediated signalling pathway protects against acetaminophen-induced liver injury. Marañón, P, Rey, E, Isaza, SC, Wu, H, Rada, P , Choya-Foces, C, Martínez-Ruiz, A, Martín, MÁ, Ramos, S, García-Monzón, C, Cubero, FJ, Valverde, ÁM , González-Rodríguez, Á . Redox Biol - 71 : 103088 (PMID: 38401290) (doi:10.1016/j.redox.2024.103088)
15 Feb | 2024 TPX2 overexpression promotes sensitivity to dasatinib in breast cancer by activating YAP transcriptional signaling. Marugán, C, Sanz-Gómez, N , Ortigosa, B , Monfort-Vengut, A , Bertinetti, C , Teijo, A, González, M , Alonso de la Vega, A, Lallena, MJ, Moreno-Bueno, G , de Cárcer, G . Mol Oncol (PMID: 38357786) (doi:10.1002/1878-0261.13602)
14 Feb | 2024 Expanding the genetic and phenotypic spectrum of congenital myasthenic syndrome: new homozygous VAMP1 splicing variants in 2 novel individuals. Cotrina-Vinagre, FJ, Rodríguez-García, ME, Del Pozo-Filíu, L, Hernández-Laín, A, Arteche-López, A, Morte, B , Sevilla, M, Pérez-Jurado, LA, Quijada-Fraile, P, Camacho, A, Martínez-Azorín, F . J Hum Genet (PMID: 38355957) (doi:10.1038/s10038-024-01228-7)
10 Feb | 2024 Clinical practice guideline on the management of vestibular schwannoma. Lassaletta, L , Acle Cervera, L, Altuna, X, Amilibia Cabeza, E, Arístegui Ruiz, M, Batuecas Caletrio, Á, Benítez Del Rosario, J, Cabanillas Farpón, R, Costales Marcos, M, Escada, P, Espinosa-Sánchez, JM, García Leal, R, Gavilán, J, Gómez Martínez, J, González-Aguado, R, Martinez-Glez, V, Guerra Jiménez, G, Harguindey Antolí-Candela, A, Hernández García, BJ, Orús Dotú, C, Polo López, R, Manrique, M, Martín Sanz, E, Martínez Álvarez, R, Martínez, H, Martínez-Martínez, M, Rey-Martinez, J, Ropero Romero, F, Santa Cruz Ruiz, S, Vallejo, LÁ, Soto Varela, A, Varela-Nieto, I , Morales Puebla, JM. Acta Otorrinolaringol Esp (Engl Ed) (PMID: 38346489) (doi:10.1016/j.otoeng.2023.10.005)
5 Feb | 2024 Fever-like temperature impacts on Staphylococcus aureus and Pseudomonas aeruginosa interaction, physiology, and virulence both in vitro and in vivo. Solar Venero, EC , Galeano, MB, Luqman, A, Ricardi, MM, Serral, F, Fernandez Do Porto, D, Robaldi, SA, Ashari, BAZ, Munif, TH, Egoburo, DE, Nemirovsky, S, Escalante, J, Nishimura, B, Ramirez, MS, Götz, F, Tribelli, PM. BMC Biol - 22 (1) : 27 (PMID: 38317219) (doi:10.1186/s12915-024-01830-3)
2 Feb | 2024 Intestinal Effects of Filtered Alkalinized Water in Lean and Obese Zucker Rats. Doblado, L , Díaz, LE, Nova, E, Marcos, A, Monsalve, M . Microorganisms - 12 (2) (PMID: 38399722) (doi:10.3390/microorganisms12020316)
2 Feb | 2024 β-cell Jagged1 is sufficient but not necessary for islet Notch activity and insulin secretory defects in obese mice. Suda, N, Bartolomé, A , Liang, J, Son, J, Yagishita, Y, Siebel, C, Accili, D, Ding, H, Pajvani, UB. Mol Metab (PMID: 38311286) (doi:10.1016/j.molmet.2024.101894)
1 Feb | 2024 Contribution of Nucleotide-Binding Oligomerization Domain-like (NOD) Receptors to the Immune and Metabolic Health. Apaza, CJ, Días, M, García Tejedor, A, Boscá, L , Laparra Llopis, JM. Biomedicines - 12 (2) (PMID: 38397943) (doi:10.3390/biomedicines12020341)
1 Feb | 2024 Hospital-based screening outperforms primary care screening as a means of achieving hepatitis C virus micro-elimination. Fernández-García, CE, Gallego-Galiana, J, Solís-Muñoz, PA, Del Pozo-Maroto, E, Domínguez-Alcón, L, Tobar-Izquierdo, M, Sáez, A, Rodríguez de Cía, J, Magaña-Sánchez, A, Real-Martínez, Y, García-Buey, L, González-Moreno, L, Caldas-Álvarez, M, Cardeñoso-Domingo, LM, González-Gamarra, A, Salvador-Calvo, A, González-Rodríguez, Á , García-Monzón, C. Infect Dis Now (PMID: 38309646) (doi:10.1016/j.idnow.2024.104855)
1 Feb | 2024 Insights on the role of thyroid hormone transport in neurosensory organs and implication for Allan-Herndon-Dudley syndrome. García-Aldea, Á , Guillén-Yunta, M , Valcárcel-Hernández, V , Montero-Pedrazuela, A , Guadaño-Ferraz, A , Bárez-López, S . Eur Thyroid J (PMID: 38417253) (doi:10.1530/ETJ-23-0241)
31 Jan | 2024 An altered expression of miR-376a-3p and miR-20a-5p in peripheral blood exosomes regulates the autophagy and inflammatory systemic substrates, and relates to the smoking habit and age in Crohn's disease. Caparrós, E, García-Martinez, I , Pedro Zapater, , Lucía Madero, , Valverde, ÁM , Ana Gutiérrez, , Francés, R. FASEB J - 38 (2) : e23418 (PMID: 38226870) (doi:10.1096/fj.202301761R)
29 Jan | 2024 Routing of Kv7.1 to endoplasmic reticulum plasma membrane junctions. Serrano-Novillo, C, Estadella, I, Navarro-Pérez, M, Oliveras, A, de Benito-Bueno, A , Socuéllamos, PG , Bosch, M, Coronado, MJ, Sastre, D, Valenzuela, C , Soeller, C, Felipe, A . Acta Physiol (Oxf) (PMID: 38282556) (doi:10.1111/apha.14106)
27 Jan | 2024 Targeting cancer stem cell OXPHOS with tailored ruthenium complexes as a new anti-cancer strategy. Alcalá, S , Villarino, L, Ruiz-Cañas, L , Couceiro, JR, Martínez-Calvo, M, Palencia-Campos, A , Navarro, D , Cabezas-Sainz, P, Rodriguez-Arabaolaza, I , Cordero-Barreal, A , Trilla-Fuertes, L, Rubiolo, JA, Batres-Ramos, S , Vallespinos, M , González-Páramos, C , Rodríguez, J, Gámez-Pozo, A , Vara, JÁF, Fernández, SF, Berlinches, AB, Moreno-Mata, N, Redondo, AMT, Carrato, A, Hermann, PC, Sánchez, L, Torrente, S, Fernández-Moreno, MÁ , Mascareñas, JL, Sainz, B . J Exp Clin Cancer Res - 43 (1) : 33 (PMID: 38281027) (doi:10.1186/s13046-023-02931-7)
23 Jan | 2024 HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling. Terri, M, Sandoval, P, Bontempi, G, Montaldo, C, Tomero-Sanz, H, de Turris, V, Trionfetti, F, Pascual-Antón, L, Clares-Pedrero, I, Battistelli, C, Valente, S, Zwergel, C, Mai, A, Rosanò, L, Del Pozo, MÁ, Sánchez-Álvarez, M , Cabañas, C, Tripodi, M, López-Cabrera, M, Strippoli, R. J Exp Clin Cancer Res - 43 (1) : 27 (PMID: 38254102) (doi:10.1186/s13046-023-02930-8)
17 Jan | 2024 Synergistic Effect of a Flavonoid-Rich Cocoa-Carob Blend and Metformin in Preserving Pancreatic Beta Cells in Zucker Diabetic Fatty Rats. Gallardo-Villanueva, P, Fernández-Marcelo, T, Villamayor, L , Valverde, AM , Ramos, S, Fernández-Millán, E, Martín, MA. Nutrients - 16 (2) (PMID: 38257166) (doi:10.3390/nu16020273)
16 Jan | 2024 HuR (ELAVL1) Stabilizes SOX9 mRNA and Promotes Migration and Invasion in Breast Cancer Cells. Morillo-Bernal, J , Pizarro-García, P , Moreno-Bueno, G , Cano, A , Mazón, MJ , Eraso, P , Portillo, F . Cancers (Basel) - 16 (2) (PMID: 38254873) (doi:10.3390/cancers16020384)
10 Jan | 2024 Cardiometabolic Changes in Sirtuin1-Heterozygous Mice on High-Fat Diet and Melatonin Supplementation. Favero, G, Golic, I, Arnaboldi, F, Cappella, A, Korac, A, Monsalve, M , Stacchiotti, A, Rezzani, R. Int J Mol Sci - 25 (2) (PMID: 38255934) (doi:10.3390/ijms25020860)
9 Jan | 2024 Trabectedin and Lurbinectedin Modulate the Interplay between Cells in the Tumour Microenvironment-Progresses in Their Use in Combined Cancer Therapy. Povo-Retana, A , Landauro-Vera, R , Alvarez-Lucena, C , Cascante, M, Boscá, L . Molecules - 29 (2) (PMID: 38257245) (doi:10.3390/molecules29020331)
6 Jan | 2024 Fatty acid amide hydrolase drives adult mammary gland development by promoting luminal cell differentiation. Tundidor, I, Seijo-Vila, M, Blasco-Benito, S, Rubert-Hernández, M, Moreno-Bueno, G , Bindila, L, de la Rosa, RF, Guzmán, M, Sánchez, C, Pérez-Gómez, E . Cell Death Discov - 10 (1) : 12 (PMID: 38184644) (doi:10.1038/s41420-023-01788-1)
3 Jan | 2024 GDF15 activates AMPK and inhibits gluconeogenesis and fibrosis in the liver by attenuating the TGF-β1/SMAD3 pathway. Jurado-Aguilar, J, Barroso, E, Bernard, M, Zhang, M, Peyman, M, Rada, P , Valverde, ÁM , Wahli, W, Palomer, X, Vázquez-Carrera, M. Metabolism - 152 : 155772 (PMID: 38176644) (doi:10.1016/j.metabol.2023.155772)
3 Jan | 2024 Specific targeting of the NRF2/β-TrCP axis promotes beneficial effects in NASH. Fernández-Ginés, R , Encinar, JA, Escoll, M , Carnicero-Senabre, D , Jiménez-Villegas, J , García-Yagüe, ÁJ , González-Rodríguez, Á , Garcia-Martinez, I , M Valverde, Á , Rojo, AI , Cuadrado, A . Redox Biol - 69 : 103027 (PMID: 38184999) (doi:10.1016/j.redox.2024.103027)