Domínguez-Ruiz, M.; Murillo-Cuesta, S. ; Contreras, J. ; Cantero, M.; Garrido, G.; Martín-Bernardo, B.; Gómez-Rosas, E.; Fernández, A.; Del Castillo, F.J.; Montoliu, L.; Varela-Nieto, I. ; Del Castillo, I. "A murine model for the del(GJB6-D13S1830) deletion recapitulating the phenotype of human DFNB1 hearing impairment: generation and functional and histopathological study." . BMC Genomics. 25(1): 359. (2024). (PMID: 38605287).
Ruiz-García, C. ; Lassaletta, L. ; López-Larrubia, P. ; Varela-Nieto, I. ; Murillo-Cuesta, S. "Tumors of the nervous system and hearing loss: Beyond vestibular schwannomas." . Hear Res. 447(): 109012. (2024). (PMID: 38703433).
García-Mato, Á. ; Cervantes, B. ; Murillo-Cuesta, S. ; Rodríguez-de la Rosa, L. ; Varela-Nieto, I. "Insulin-like Growth Factor 1 Signaling in Mammalian Hearing." . Genes (Basel). 12(10): . (2021). (PMID: 34680948).
Varela-Nieto, I. ; Murillo-Cuesta, S. ; Rodríguez-de la Rosa, L. ; Oset-Gasque, M.J.; Marco-Contelles, J. "Use of Radical Oxygen Species Scavenger Nitrones to Treat Oxidative Stress-Mediated Hearing Loss: State of the Art and Challenges." . Front Cell Neurosci. 15(): 711269. (2021). (PMID: 34539349).
Murillo-Cuesta, S. ; Celaya, A.M. ; Cervantes, B. ; Bermúdez-Muñoz, J.M. ; Rodríguez-de la Rosa, L. ; Contreras, J. ; Sánchez-Pérez, I. ; Varela-Nieto, I. "Therapeutic efficiency of the APAF-1 antagonist LPT99 in a rat model of cisplatin-induced hearing loss." . Clin Transl Med. 11(4): e363. (2021). (PMID: 33931965).
Murillo-Cuesta, S. ; Artuch, R.; Asensio, F.; de la Villa, P.; Dierssen, M.; Enríquez, J.A.; Fillat, C.; Fourcade, S.; Ibáñez, B.; Montoliu, L.; Oliver, E.; Pujol, A.; Salido, E.; Vallejo, M. ; Varela-Nieto, I. "The Value of Mouse Models of Rare Diseases: A Spanish Experience." . Front Genet. 11(): 583932. (2020). (PMID: 33173540).
Varela-Nieto, I. ; Murillo-Cuesta, S. ; Calvino, M.; Cediel, R. ; Lassaletta, L. "Drug development for noise-induced hearing loss." . Expert Opin Drug Discov. (): 1-15. (2020). (PMID: 32838572).
Cervantes, B. ; Arana, L.; Murillo-Cuesta, S. ; Bruno, M.; Alkorta, I.; Varela-Nieto, I. "Solid Lipid Nanoparticles Loaded with Glucocorticoids Protect Auditory Cells from Cisplatin-Induced Ototoxicity." . J Clin Med. 8(9): . (2019). (PMID: 31540035).
Partearroyo, T. ; Murillo-Cuesta, S. ; Vallecillo, N. ; Bermúdez-Muñoz, J.M. ; Rodríguez-de la Rosa, L. ; Mandruzzato, G.; Celaya, A.M. ; Zeisel, S.H.; Pajares, M.A. ; Varela-Moreiras, G. ; Varela-Nieto, I. "Betaine-homocysteine S -methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia." . FASEB J.. 33(5): 5942-5956. (2019). (PMID: 30753104).
Celaya, A.M. ; Sánchez-Pérez, I. ; Bermúdez-Muñoz, J.M. ; Rodríguez-de la Rosa, L. ; Pintado-Berninches, L. ; Perona, R. ; Murillo-Cuesta, S. ; Varela-Nieto, I. "Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss." . Elife. 8(): . (2019). (PMID: 30938680).
Wesdorp, M.; Murillo-Cuesta, S. ; Peters, T.; Celaya, A.M. ; Oonk, A.; Schraders, M.; Oostrik, J.; Gomez-Rosas, E.; Beynon, A.J.; Hartel, B.P.; Okkersen, K.; Koenen, H.J.P.M.; Weeda, J.; Lelieveld, S.; Voermans, N.C.; Joosten, I.; Hoyng, C.B.; Lichtner, P.; Kunst, H.P.M.; Feenstra, I.; de Bruijn, S.E.; , .; Admiraal, R.J.C.; Yntema, H.G.; van Wijk, E.; Del Castillo, I.; Serra, P.; Varela-Nieto, I. ; Pennings, R.J.E.; Kremer, H. "MPZL2, Encoding the Epithelial Junctional Protein Myelin Protein Zero-like 2, Is Essential for Hearing in Man and Mouse." . Am. J. Hum. Genet.. 103(1): 74-88. (2018). (PMID: 29961571).
Espino Guarch, M.; Font-Llitjós, M.; Murillo-Cuesta, S. ; Errasti-Murugarren, E.; Celaya, A.M. ; Girotto, G.; Vuckovic, D.; Mezzavilla, M.; Vilches, C.; Bodoy, S.; Sahún, I.; González, L. ; Prat, E.; Zorzano, A.; Dierssen, M.; Varela-Nieto, I. ; Gasparini, P.; Palacín, M.; Nunes, V. "Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss." . Elife. 7(): . (2018). (PMID: 29355479).
García-Alcántara, F. ; Murillo-Cuesta, S. ; Pulido, S. ; Bermúdez-Muñoz, J.M. ; Martínez-Vega, R. ; Milo, M. ; Varela-Nieto, I. ; Rivera, T. "The expression of oxidative stress response genes is modulated by a combination of resveratrol and N-acetylcysteine to ameliorate ototoxicity in the rat cochlea." . Hear. Res.. 358(): 10-21. (2017). (PMID: 29304389).
Rodríguez-de la Rosa, L. ; Lassaletta, L. ; Calvino, M.; Murillo-Cuesta, S. ; Varela-Nieto, I. "The Role of Insulin-Like Growth Factor 1 in the Progression of Age-Related Hearing Loss." . Front Aging Neurosci. 9(): 411. (2017). (PMID: 29311900).
Murillo-Cuesta, S. ; Vallecillo, N. ; Cediel, R. ; Celaya, A.M. ; Lassaletta, L. ; Varela-Nieto, I. ; Contreras, J. "A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection." . J Vis Exp. (121): . (2017). (PMID: 28362376).
Arroba, A.I. ; Rodríguez-de la Rosa, L. ; Murillo-Cuesta, S. ; Vaquero-Villanueva, L.; Hurlé, J.M.; Varela-Nieto, I. ; Valverde, Á.M. "Autophagy resolves early retinal inflammation in Igf1-deficient mice." . Dis Model Mech. 9(9): 965-974. (2016). (PMID: 27483352).
Martínez-Vega, R. ; Murillo-Cuesta, S. ; Partearroyo, T. ; Varela-Moreiras, G. ; Varela-Nieto, I. ; Pajares, M.A. "Long-Term Dietary Folate Deficiency Accelerates Progressive Hearing Loss on CBA/Ca Mice." . Front Aging Neurosci. 8(): 209. (2016). (PMID: 27630560).
Fuentes-Santamaría, V.; Alvarado, J.C.; Rodríguez-de la Rosa, L. ; Murillo-Cuesta, S. ; Contreras, J. ; Juiz, J.M.; Varela-Nieto, I. "Erratum to: IGF-1 deficiency causes atrophic changes associated with upregulation of VGluT1 and downregulation of MEF2 transcription factors in the mouse cochlear nuclei." . Brain Struct Funct. 221(2): 1205. (2016). (PMID: 25416135).
Fuentes-Santamaría, V.; Alvarado, J.C.; Rodríguez-de la Rosa, L. ; Murillo-Cuesta, S. ; Contreras, J. ; Juiz, J.M.; Varela-Nieto, I. "IGF-1 deficiency causes atrophic changes associated with upregulation of VGluT1 and downregulation of MEF2 transcription factors in the mouse cochlear nuclei." . Brain Struct Funct. 221(2): 709-734. (2016). (PMID: 25378055).
Rodríguez-de la Rosa, L. ; Sánchez-Calderón, H. ; Contreras, J. ; Murillo-Cuesta, S. ; Falagan, S.; Avendaño, C.; Dopazo, J.; Varela-Nieto, I. ; Milo, M. "Comparative gene expression study of the vestibular organ of the Igf1 deficient mouse using whole-transcript arrays." . Hear. Res.. (): . (2015). (PMID: 26341476).
Sanz, L. ; Murillo-Cuesta, S. ; Cobo, P.; Cediel, R. ; Contreras, J. ; Rivera, T. ; Varela-Nieto, I. ; Avendaño, C. "Corrigendum to: Swept-sine noise-induced damage as a hearing loss model for preclinical assays." . Front Aging Neurosci. 7(): 79. (2015). (PMID: 26029100).
Murillo-Cuesta, S. ; Rodríguez-de la Rosa, L. ; Contreras, J. ; Celaya, A.M. ; Camarero, G. ; Rivera, T. ; Varela-Nieto, I. "Corrigendum: Transforming growth factor β1 inhibition protects from noise-induced hearing loss." . Front Aging Neurosci. 7(): 72. (2015). (PMID: 26005416).
Murillo-Cuesta, S. ; Rodríguez-de la Rosa, L. ; Contreras, J. ; Celaya, A.M. ; Camarero, G. ; Rivera, T. ; Varela-Nieto, I. "Transforming growth factor β1 inhibition protects from noise-induced hearing loss." . Front Aging Neurosci. 7(): 32. (2015). (PMID: 25852546).
Sanz, L. ; Murillo-Cuesta, S. ; Cobo, P.; Cediel-Algovia, R.; Contreras, J. ; Rivera, T. ; Varela-Nieto, I. ; Avendaño, C. "Swept-sine noise-induced damage as a hearing loss model for preclinical assays." . Front Aging Neurosci. 7(): 7. (2015). (PMID: 25762930).
Rodríguez-de la Rosa, L. ; López-Herradón, A.; Portal-Núñez, S.; Murillo-Cuesta, S. ; Lozano, D.; Cediel, R. ; Varela-Nieto, I. ; Esbrit, P. "Treatment with N- and C-terminal peptides of parathyroid hormone-related protein partly compensate the skeletal abnormalities in IGF-I deficient mice." . PLoS ONE. 9(2): e87536. (2014). (PMID: 24503961).
Muñoz-Espín, D.; Cañamero, M.; Maraver, A.; Gómez-López, G.; Contreras, J. ; Murillo-Cuesta, S. ; Rodríguez-Baeza, A.; Varela-Nieto, I. ; Ruberte, J.; Collado, M.; Serrano, M. "Programmed cell senescence during mammalian embryonic development." . Cell. 155(5): 1104-1118. (2013). (PMID: 24238962).
Varela-Nieto, I. ; Murillo-Cuesta, S. ; Rodríguez-de la Rosa, L. ; Lassatetta, L.; Contreras, J. "IGF-I deficiency and hearing loss: molecular clues and clinical implications." . Pediatr Endocrinol Rev. 10(4): 460-472. (2013). (PMID: 23957197).
Rodriguez-de la Rosa, L. ; Fernandez-Sanchez, L.; Germain, F.; Murillo-Cuesta, S. ; Varela-Nieto, I. ; de la Villa, P.; Cuenca, N. "Age-related functional and structural retinal modifications in the Igf1-/- null mouse." . Neurobiol. Dis.. 46(2): 476-485. (2012). (PMID: 22402333).
Murillo-Cuesta, S. ; Camarero, G. ; González-Rodríguez, A. ; De La Rosa, L.R. ; Burks, D.J.; Avendaño, C.; Valverde, A.M. ; Varela-Nieto, I. "Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function." . Mol. Med.. 18(): 260-269. (2012). (PMID: 22160220).
Murillo-Cuesta, S. ; Rodríguez-de la Rosa, L. ; Cediel, R. ; Lassaletta, L. ; Varela-Nieto, I. "The role of insulin-like growth factor-I in the physiopathology of hearing." . Front Mol Neurosci. 4(): 11. (2011). (PMID: 21845174).
Riquelme, R. ; Cediel, R. ; Contreras, J. ; la Rosa Lourdes, R.D. ; Murillo-Cuesta, S. ; Hernandez-Sanchez, C.; Zubeldia, J.M. ; Cerdan, S. ; Varela-Nieto, I. "A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice." . Front Neuroanat. 4(): 27. (2010). (PMID: 20661454).
Murillo-Cuesta, S. ; Contreras, J. ; Cediel, R. ; Varela-Nieto, I. "Comparison of different aminoglycoside antibiotic treatments to refine ototoxicity studies in adult mice." . Lab. Anim.. 44(2): 124-131. (2010). (PMID: 19858169).
Murillo-Cuesta, S. ; Contreras, J. ; Zurita, E.; Cediel, R. ; Cantero, M.; Varela-Nieto, I. ; Montoliu, L. "Melanin precursors prevent premature age-related and noise-induced hearing loss in albino mice." . Pigment Cell Melanoma Res. 23(1): 72-83. (2010). (PMID: 19843244).
Murillo-Cuesta, S. ; García-Alcántara, F. ; Vacas, E. ; Sistiaga, J.A.; Camarero, G. ; Varela-Nieto, I. ; Rivera, T. "Direct drug application to the round window: a comparative study of ototoxicity in rats." . Otolaryngol Head Neck Surg. 141(5): 584-590. (2009). (PMID: 19861195).
Rodríguez-de la Rosa, L. ; Contreras-Rodríguez, J. ; Cediel-Algovia, R. ; León, Y. ; Sánchez-Calderón, H. ; Murillo-Cuesta, S. ; Riquelme-Galiana, R. ; de Diego-Sastre, J.I. ; Prim-Espada, M.P. ; Varela-Nieto, I. ; , . "[Neurotrophic action of insulin-like growth factor-I in the inner ear]." . Rev Neurol. 45(4): 245-250. (2008). (PMID: 17668408).