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PUBLICACIONES

 

 

spacerTrabajos Publicados por Pilar Santisteban Sanz
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  1. Haderk, F.; Chou, Y.T.; Cech, L.; Fernández-Méndez, C.; Yu, J.; Olivas, V.; Meraz, I.M.; Barbosa Rabago, D.; Kerr, D.L.; Gomez, C.; Allegakoen, D.V.; Guan, J.; Shah, K.N.; Herrington, K.A.; Gbenedio, O.M.; Nanjo, S.; Majidi, M.; Tamaki, W.; Pourmoghadam, Y.K.; Rotow, J.K.; McCoach, C.E.; Riess, J.W.; Gutkind, J.S.; Tang, T.T.; Post, L.; Huang, B.; Santisteban, P.; Goodarzi, H.; Bandyopadhyay, S.; Kuo, C.J.; Roose, J.P.; Wu, W.; Blakely, C.M.; Roth, J.A.; Bivona, T.G. "Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer.". Nat Commun. 15(1): 3741. (2024). (PMID: 38702301).
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  2. Kang, H.S.; Grimm, S.A.; Jothi, R.; Santisteban, P.; Jetten, A.M. "GLIS3 regulates transcription of thyroid hormone biosynthetic genes in coordination with other thyroid transcription factors.". Cell Biosci. 13(1): 32. (2023). (PMID: 36793061).
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  3. Zaballos, M.A.; Acuña-Ruiz, A.; Morante, M.; Riesco-Eizaguirre, G.; Crespo, P.; Santisteban, P. "Inhibiting ERK dimerization ameliorates BRAF-driven anaplastic thyroid cancer.". Cell Mol Life Sci. 79(9): 504. (2022). (PMID: 36056964).
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  4. Koumarianou, P.; Fernández-Méndez, C.; Fajardo-Delgado, D.; Mielu, L.M.; Santisteban, P.; de la Vieja, A. "Basolateral sorting of the sodium iodide symporter NIS is mediated by AP-1 clathrin adaptor complexes.". Thyroid. (): . (2022). (PMID: 35833460).
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  5. Ramírez-Moya, J.; Wert-Lamas, L.; Acuña-Ruíz, A.; Fletcher, A.; Wert-Carvajal, C.; McCabe, C.J.; Santisteban, P.; Riesco-Eizaguirre, G. "Identification of an interactome network between lncRNAs and miRNAs in thyroid cancer reveals SPTY2D1-AS1 as a new tumor suppressor.". Sci Rep. 12(1): 7706. (2022). (PMID: 35562181).
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  6. Acuña-Ruiz, A.; Carrasco-López, C.; Santisteban, P. "Genomic and epigenomic profile of thyroid cancer.". Best Pract Res Clin Endocrinol Metab. (): 101656. (2022). (PMID: 35461756).
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  7. Baker, A.R.; Miliotis, C.; Ramírez-Moya, J.; Marc, T.; Vlachos, I.S.; Santisteban, P.; Slack, F.J. "Transcriptome profiling of ADAR1 targets in triple-negative breast cancer cells reveals mechanisms for regulating growth and invasion.". Mol Cancer Res. (): . (2022). (PMID: 35247916).
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  8. López-Márquez, A.; Carrasco-López, C.; Martínez-Cano, A.; Lemoine, P.; Pierreux, C.E.; Santisteban, P. "Sox9 is involved in the thyroid differentiation program and is regulated by crosstalk between TSH, TGFβ and thyroid transcription factors.". Sci Rep. 12(1): 2144. (2022). (PMID: 35140269).
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  9. Jankovic Miljus, J.; Guillén-Sacoto, M.A.; Makiadi-Alvarado, J.; Wert-Lamas, L.; Ramirez-Moya, J.; Robledo, M.; Santisteban, P.; Riesco-Eizaguirre, G. "Circulating MicroRNA Profiles as Potential Biomarkers for differentiated thyroid cancer recurrence.". J Clin Endocrinol Metab. (): . (2022). (PMID: 35022762).
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  10. Fernández-Méndez, C.; Santisteban, P. "A critical balance between Pax8 and the Hippo mediator TAZ determines sodium-iodide symporter NIS expression and function.". Thyroid. (): . (2021). (PMID: 34726504).
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  11. Ramírez-Moya, J.; Miliotis, C.; Baker, A.R.; Gregory, R.I.; Slack, F.J.; Santisteban, P. "An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks.". Mol Cancer. 20(1): 115. (2021). (PMID: 34496885).
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  12. Riesco-Eizaguirre, G.; Santisteban, P.; De la Vieja, A. "The complex regulation of NIS expression and activity in thyroid and extrathyroidal tissues.". Endocr Relat Cancer. (): . (2021). (PMID: 34387194).
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  13. Tao, Y.; Wang, F.; Shen, X.; Zhu, G.; Liu, R.; Viola, D.; Elisei, R.; Puxeddu, E.; Fugazzola, L.; Colombo, C.; Jarzab, B.; Czarniecka, A.; Lam, A.K.; Mian, C.; Vianello, F.; Yip, L.; Riesco-Eizaguirre, G.; Santisteban, P.; O'Neill, C.J.; Sywak, M.S.; Clifton-Bligh, R.; Bendlova, B.; Sýkorová, V.; Zhao, S.; Wang, Y.; Xing, M. "BRAF V600E Status Sharply Differentiates Lymph Node Metastasis-associated Mortality Risk in Papillary Thyroid Cancer.". J Clin Endocrinol Metab. (): . (2021). (PMID: 34273152).
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  14. López-Márquez, A.; Carrasco-López, C.; Fernández-Méndez, C.; Santisteban, P. "Unraveling the Complex Interplay Between Transcription Factors and Signaling Molecules in Thyroid Differentiation and Function, From Embryos to Adults.". Front Endocrinol (Lausanne). 12(): 654569. (2021). (PMID: 33959098).
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  15. Ramírez-Moya, J.; Santisteban, P. "A positive feedback loop between DICER1 and differentiation transcription factors is important for thyroid tumorigenesis.". Thyroid. (): . (2020). (PMID: 33176626).
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  16. García-Ibáñez, Y.; Riesco-Eizaguirre, G.; Santisteban, P.; Casar, B.; Crespo, P. "RAS Subcellular Localization Inversely Regulates Thyroid Tumor Growth and Dissemination.". Cancers (Basel). 12(9): . (2020). (PMID: 32927904).
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  17. Iwafuchi, M.; Cuesta, I.; Donahue, G.; Takenaka, N.; Osipovich, A.B.; Magnuson, M.A.; Roder, H.; Seeholzer, S.H.; Santisteban, P.; Zaret, K.S. "Gene network transitions in embryos depend upon interactions between a pioneer transcription factor and core histones.". Nat. Genet.. 52(4): 418-427. (2020). (PMID: 32203463).
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  18. Pernía, O.; Sastre-Perona, A.; Rodriguez-Antolín, C.; García-Guede, A.; Palomares-Bralo, M.; Rosas, R.; Sanchez-Cabrero, D.; Cruz, P.; Rodriguez, C.; Diestro, M.; Martín-Arenas, R.; Pulido, V.; Santisteban, P.; Castro, J.; Vera, O.; Cáceres, I.I. "A Novel Role for the Tumor Suppressor Gene ITF2 in Tumorigenesis and Chemotherapy Response.". Cancers (Basel). 12(4): . (2020). (PMID: 32224864).
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  19. Ramírez-Moya, J.; Baker, A.R.; Slack, F.J.; Santisteban, P. "ADAR1-mediated RNA editing is a novel oncogenic process in thyroid cancer and regulates miR-200 activity.". Oncogene. (): . (2020). (PMID: 32157211).
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  20. Morillo-Bernal, J.; Fernández, L.P.; Santisteban, P. "FOXE1 regulates migration and invasion in thyroid cancer cells and targets ZEB1.". Endocr. Relat. Cancer. (): . (2019). (PMID: 31846430).
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  21. Serrano-Nascimento, C.; Morillo-Bernal, J.; Rosa-Ribeiro, R.; Nunes, M.T.; Santisteban, P. "Impaired gene expression due to iodine excess in the development and differentiation of endoderm and thyroid is associated with epigenetic changes.". Thyroid. (): . (2019). (PMID: 31801416).
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  22. Kim, K.J.; Kim, S.G.; Tan, J.; Shen, X.; Viola, D.; Elisei, R.; Puxeddu, E.; Fugazzola, L.; Colombo, C.; Jarzab, B.; Czarniecka, A.; Lam, A.K.; Mian, C.; Vianello, F.; Yip, L.; Riesco-Eizaguirre, G.; Santisteban, P.; O'Neill, C.J.; Sywak, M.S.; Clifton-Bligh, R.; Bendlova, B.; Sýkorová, V.; Xing, M. "BRAF V600E status may facilitate decision-making on active surveillance of low-risk papillary thyroid microcarcinoma.". Eur. J. Cancer. 124(): 161-169. (2019). (PMID: 31790974).
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  23. Ramirez-Moya, J.; Wert-Lamas, L.; Acuña-Ruiz, A.; Zaballos, M.A.; Santisteban, P. "In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice.". J Vis Exp. (150): . (2019). (PMID: 31498304).
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  24. Ramírez-Moya, J.; Wert-Lamas, L.; Riesco-Eizaguirre, G.; Santisteban, P. "Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness.". Oncogene. 38(27): 5486-5499. (2019). (PMID: 30967628).
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  25. Ramírez-Moya, J.; Santisteban, P. "miRNA-Directed Regulation of the Main Signaling Pathways in Thyroid Cancer.". Front Endocrinol (Lausanne). 10(): 430. (2019). (PMID: 31312183).
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  26. Zaballos, M.A.; Acuña-Ruiz, A.; Morante, M.; Crespo, P.; Santisteban, P. "Regulators of the RAS-ERK pathway as therapeutic targets in thyroid cancer.". Endocr. Relat. Cancer. 26(6): R319-R344. (2019). (PMID: 30978703).
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  27. López-Márquez, A.; Fernández-Méndez, C.; Recacha, P.; Santisteban, P. "Regulation of Foxe1 by Thyrotropin and Transforming Growth Factor Beta Depends on the Interplay Between Thyroid-Specific, CREB and SMAD Transcription Factors.". Thyroid. 29(5): 714-725. (2019). (PMID: 30652527).
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  28. Choe, J.; Lin, S.; Zhang, W.; Liu, Q.; Wang, L.; Ramirez-Moya, J.; Du, P.; Kim, W.; Tang, S.; Sliz, P.; Santisteban, P.; George, R.E.; Richards, W.G.; Wong, K.K.; Locker, N.; Slack, F.J.; Gregory, R.I. "mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis.". Nature. (): . (2018). (PMID: 30232453).
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  29. Wang, F.; Zhao, S.; Shen, X.; Zhu, G.; Liu, R.; Viola, D.; Elisei, R.; Puxeddu, E.; Fugazzola, L.; Colombo, C.; Jarzab, B.; Czarniecka, A.; Lam, A.K.; Mian, C.; Vianello, F.; Yip, L.; Riesco-Eizaguirre, G.; Santisteban, P.; O'Neill, C.J.; Sywak, M.S.; Clifton-Bligh, R.; Bendlova, B.; Sýkorová, V.; Wang, Y.; Xing, M. "BRAF V600E Confers Male Sex Disease-Specific Mortality Risk in Patients With Papillary Thyroid Cancer.". J. Clin. Oncol.. (): JCO2018785097. (2018). (PMID: 30070937).
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  30. Ramírez-Moya, J.; Santisteban, P. "An oncogenic role for microRNA-146b in the thyroid.". Oncoscience. 5(5-6): 155-156. (2018). (PMID: 30035174).
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  31. Peyret, V.; Nazar, M.; Martín, M.; Quintar, A.A.; Fernandez, E.A.; Geysels, R.C.; Fuziwara, C.S.; Montesinos, M.M.; Maldonado, C.A.; Santisteban, P.; Kimura, E.T.; Pellizas, C.G.; Nicola, J.P.; Masini-Repiso, A.M. "Functional Toll-like Receptor 4 Overexpression in Papillary Thyroid Cancer by MAPK/ERK-Induced ETS1 Transcriptional Activity.". Mol. Cancer Res.. 16(5): 833-845. (2018). (PMID: 29523762).
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  32. Ziros, P.G.; Habeos, I.; Chartoumpekis, D.V.; Ntalampyra, E.; Somm, E.; Renaud, C.O.; Bongiovanni, M.; Trougakos, I.P.; Yamamoto, M.; Kensler, T.W.; Santisteban, P.; Carrasco, N.; Ris-Stalpers, C.; Amendola, E.; Liao, X.H.; Rossich, L.; Thomasz, L.; Juvenal, G.J.; Refetoff, S.; Sykiotis, G.P. "The NFE2-related transcription factor 2 (Nrf2) coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland.". Thyroid. (): . (2018). (PMID: 29742982).
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  33. Huang, Y.; Qu, S.; Zhu, G.; Wang, F.; Liu, R.; Shen, X.; Viola, D.; Elisei, R.; Puxeddu, E.; Fugazzola, L.; Colombo, C.; Jarzab, B.; Czarniecka, A.; Lam, A.K.; Mian, C.; Vianello, F.; Yip, L.; Riesco-Eizaguirre, G.; Santisteban, P.; O'Neill, C.J.; Sywak, M.S.; Clifton-Bligh, R.; Bendlova, B.; Sýkorová, V.; Xing, M. "BRAF V600E Mutation-Assisted Risk Stratification of Solitary Intrathyroidal Papillary Thyroid Cancer for Precision Treatment.". J. Natl. Cancer Inst.. 110(4): 362-370. (2018). (PMID: 29165667).
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  34. De la Vieja, A.; Santisteban, P. "Role of iodide metabolism in physiology and cancer.". Endocr. Relat. Cancer. 25(4): R225-R245. (2018). (PMID: 29437784).
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  35. Moya, C.M.; Zaballos, M.A.; Garzón, L.; Luna, C.; Simón, R.; Yaffe, M.B.; Gallego, E.; Santisteban, P.; Moreno, J.C. "TAZ/WWTR1 Mediates the Pulmonary Effects of NKX2-1 Mutations in Brain-Lung-Thyroid Syndrome.". J. Clin. Endocrinol. Metab.. 103(3): 839-852. (2018). (PMID: 29294041).
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  36. Shen, X.; Zhu, G.; Liu, R.; Viola, D.; Elisei, R.; Puxeddu, E.; Fugazzola, L.; Colombo, C.; Jarzab, B.; Czarniecka, A.; Lam, A.K.; Mian, C.; Vianello, F.; Yip, L.; Riesco-Eizaguirre, G.; Santisteban, P.; O'Neill, C.J.; Sywak, M.S.; Clifton-Bligh, R.; Bendlova, B.; Sýkorová, V.; Xing, M. "Patient Age-Associated Mortality Risk Is Differentiated by BRAF V600E Status in Papillary Thyroid Cancer.". J. Clin. Oncol.. 36(5): 438-445. (2018). (PMID: 29240540).
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  37. Ramírez-Moya, J.; Wert-Lamas, L.; Santisteban, P. "MicroRNA-146b promotes PI3K/AKT pathway hyperactivation and thyroid cancer progression by targeting PTEN.". Oncogene. (): . (2018). (PMID: 29353884).
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  38. Zaballos, M.A.; Santisteban, P. "Key signaling pathways in thyroid cancer.". J. Endocrinol.. 235(2): R43-R61. (2017). (PMID: 28838947).
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  39. Wang, F.; Yu, X.; Shen, X.; Zhu, G.; Huang, Y.; Liu, R.; Viola, D.; Elisei, R.; Puxeddu, E.; Fugazzola, L.; Colombo, C.; Jarzab, B.; Czarniecka, A.; Lam, A.K.; Mian, C.; Vianello, F.; Yip, L.; Riesco-Eizaguirre, G.; Santisteban, P.; O'Neill, C.J.; Sywak, M.S.; Clifton-Bligh, R.; Bendlova, B.; Sýkorová, V.; Wang, Y.; Liu, S.; Zhao, J.; Zhao, S.; Xing, M. "The Prognostic Value of Tumor Multifocality in Clinical Outcomes of Papillary Thyroid Cancer.". J. Clin. Endocrinol. Metab.. 102(9): 3241-3250. (2017). (PMID: 28582521).
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  40. Koumarianou, P.; Goméz-López, G.; Santisteban, P. "Pax8 controls thyroid follicular polarity through cadherin-16.". J. Cell. Sci.. 130(1): 219-231. (2017). (PMID: 27780871).
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  41. Riesco-Eizaguirre, G.; Santisteban, P. "ENDOCRINE TUMOURS: Advances in the molecular pathogenesis of thyroid cancer: lessons from the cancer genome.". Eur. J. Endocrinol.. 175(5): R203-17. (2016). (PMID: 27666535).
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  42. Sastre-Perona, A.; Riesco-Eizaguirre, G.; Zaballos, M.A.; Santisteban, P. "β-catenin signaling is required for RAS-driven thyroid cancer through PI3K activation.". Oncotarget. 7(31): 49435-49449. (2016). (PMID: 27384483).
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  43. Leoni, S.G.; Sastre-Perona, A.; De la Vieja, A.; Santisteban, P. "Selenium increases TSH-induced sodium/iodide symporter expression through Txn/Ape1-dependent regulation of Pax8 binding activity.". Antioxid. Redox Signal.. (): . (2015). (PMID: 26650895).
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  44. Romaní-Pérez, M.; Outeiriño-Iglesias, V.; Moya, C.M.; Santisteban, P.; González-Matías, L.C.; Vigo, E.; Mallo, F. "Activation of the GLP-1 Receptor by Liraglutide Increases ACE2 Expression, Reversing Right Ventricle Hypertrophy, and Improving the Production of SP-A and SP-B in the Lungs of Type 1 Diabetes Rats.". Endocrinology. 156(10): 3559-3569. (2015). (PMID: 26196539).
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  45. Riesco-Eizaguirre, G.; Wert-Lamas, L.; Perales-Patón, J.; Sastre-Perona, A.; Fernández, L.P.; Santisteban, P. "The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells during Carcinogenesis.". Cancer Res.. 75(19): 4119-4130. (2015). (PMID: 26282166).
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  46. Mancikova, V.; Cruz, R.; Inglada-Pérez, L.; Fernández-Rozadilla, C.; Landa, I.; Cameselle-Teijeiro, J.; Celeiro, C.; Pastor, S.; Velázquez, A.; Marcos, R.; Andía, V.; Álvarez-Escolá, C.; Meoro, A.; Schiavi, F.; Opocher, G.; Quintela, I.; Ansede-Bermejo, J.; Ruiz-Ponte, C.; Santisteban, P.; Robledo, M.; Carracedo, A. "Thyroid cancer GWAS identifies 10q26.12 and 6q14.1 as novel susceptibility loci and reveals genetic heterogeneity among populations.". Int. J. Cancer. 137(8): 1870-1878. (2015). (PMID: 25855579).
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  47. Mancikova, V.; Castelblanco, E.; Pineiro-Yanez, E.; Perales-Paton, J.; de Cubas, A.A.; Inglada-Perez, L.; Matias-Guiu, X.; Capel, I.; Bella, M.; Lerma, E.; Riesco-Eizaguirre, G.; Santisteban, P.; Maravall, F.; Mauricio, D.; Al-Shahrour, F.; Robledo, M. "MicroRNA deep-sequencing reveals master regulators of follicular and papillary thyroid tumors.". Mod. Pathol.. 28(6): 748-757. (2015). (PMID: 25720323).
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  48. Cardoso-Weide, L.C.; Cardoso-Penha, R.C.; Costa, M.W.; Ferreira, A.C.; Carvalho, D.P.; Santisteban, P.S. "DuOx2 Promoter Regulation by Hormones, Transcriptional Factors and the Coactivator TAZ.". Eur Thyroid J. 4(1): 6-13. (2015). (PMID: 25960956).
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  49. Xing, M.; Alzahrani, A.S.; Carson, K.A.; Shong, Y.K.; Kim, T.Y.; Viola, D.; Elisei, R.; Bendlová, B.; Yip, L.; Mian, C.; Vianello, F.; Tuttle, R.M.; Robenshtok, E.; Fagin, J.A.; Puxeddu, E.; Fugazzola, L.; Czarniecka, A.; Jarzab, B.; O'Neill, C.J.; Sywak, M.S.; Lam, A.K.; Riesco-Eizaguirre, G.; Santisteban, P.; Nakayama, H.; Clifton-Bligh, R.; Tallini, G.; Holt, E.H.; Sýkorová, V. "Association between BRAF V600E mutation and recurrence of papillary thyroid cancer.". J. Clin. Oncol.. 33(1): 42-50. (2015). (PMID: 25332244).
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  50. Fernández, L.P.; López-Márquez, A.; Santisteban, P. "Thyroid transcription factors in development, differentiation and disease.". Nat Rev Endocrinol. 11(1): 29-42. (2015). (PMID: 25350068).
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  51. Riesco-Eizaguirre, G.; Leoni, S.G.; Mendiola, M.; Estevez-Cebrero, M.A.; Gallego, M.I.; Redondo, A.; Hardisson, D.; Santisteban, P.; De la Vieja, A. "NIS mediates iodide uptake in the female reproductive tract and is a poor prognostic factor in ovarian cancer.". J. Clin. Endocrinol. Metab.. 99(7): E1199-208. (2014). (PMID: 24708099).
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  52. Sastre-Perona, A.; Santisteban, P. "Wnt-independent role of β-catenin in thyroid cell proliferation and differentiation.". Mol. Endocrinol.. 28(5): 681-695. (2014). (PMID: 24645679).
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  53. Landa, I.; Boullosa, C.; Inglada-Pérez, L.; Sastre-Perona, A.; Pastor, S.; Velázquez, A.; Mancikova, V.; Ruiz-Llorente, S.; Schiavi, F.; Marcos, R.; Malats, N.; Opocher, G.; Diaz-Uriarte, R.; Santisteban, P.; Valencia, A.; Robledo, M. "An epistatic interaction between the PAX8 and STK17B genes in papillary thyroid cancer susceptibility.". PLoS ONE. 8(9): e74765. (2013). (PMID: 24086368).
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  54. Rodríguez-Rodero, S.; Fernández, A.F.; Fernández-Morera, J.L.; Castro-Santos, P.; Bayon, G.F.; Ferrero, C.; Urdinguio, R.G.; Gonzalez-Marquez, R.; Suarez, C.; Fernández-Vega, I.; Fresno Forcelledo, M.F.; Martínez-Camblor, P.; Mancikova, V.; Castelblanco, E.; Perez, M.; Marrón, P.I.; Mendiola, M.; Hardisson, D.; Santisteban, P.; Riesco-Eizaguirre, G.; Matías-Guiu, X.; Carnero, A.; Robledo, M.; Delgado-Álvarez, E.; Menéndez-Torre, E.; Fraga, M.F. "DNA methylation signatures identify biologically distinct thyroid cancer subtypes.". J. Clin. Endocrinol. Metab.. 98(7): 2811-2821. (2013). (PMID: 23666970).
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  55. Fernández, L.P.; López-Márquez, A.; Martínez, A.M.; Gómez-López, G.; Santisteban, P. "New insights into FoxE1 functions: identification of direct FoxE1 targets in thyroid cells.". PLoS ONE. 8(5): e62849. (2013). (PMID: 23675434).
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  56. Xing, M.; Alzahrani, A.S.; Carson, K.A.; Viola, D.; Elisei, R.; Bendlova, B.; Yip, L.; Mian, C.; Vianello, F.; Tuttle, R.M.; Robenshtok, E.; Fagin, J.A.; Puxeddu, E.; Fugazzola, L.; Czarniecka, A.; Jarzab, B.; O'Neill, C.J.; Sywak, M.S.; Lam, A.K.; Riesco-Eizaguirre, G.; Santisteban, P.; Nakayama, H.; Tufano, R.P.; Pai, S.I.; Zeiger, M.A.; Westra, W.H.; Clark, D.P.; Clifton-Bligh, R.; Sidransky, D.; Ladenson, P.W.; Sykorova, V. "Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer.". JAMA. 309(14): 1493-1501. (2013). (PMID: 23571588).
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  57. Zaballos, M.A.; Santisteban, P. "FOXO1 controls thyroid cell proliferation in response to TSH and IGF-I and is involved in thyroid tumorigenesis.". Mol. Endocrinol.. 27(1): 50-62. (2013). (PMID: 23160481).
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  58. Ruiz-Llorente, S.; Carrillo Santa de Pau, E.; Sastre-Perona, A.; Montero-Conde, C.; Gómez-López, G.; Fagin, J.A.; Valencia, A.; Pisano, D.G.; Santisteban, P. "Genome-wide analysis of Pax8 binding provides new insights into thyroid functions.". BMC Genomics. 13(): 147. (2012). (PMID: 22531031).
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  59. Chocarro-Calvo, A.; Zaballos, M.A.; Santisteban, P.; García-Jiménez, C. "DARPP-32 is required for MAPK/ERK signaling in thyroid cells.". Mol. Endocrinol.. 26(3): 471-480. (2012). (PMID: 22301787).
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  60. Sastre-Perona, A.; Santisteban, P. "Role of the wnt pathway in thyroid cancer.". Front Endocrinol (Lausanne). 3(): 31. (2012). (PMID: 22645520).
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  61. Leoni, S.G.; Kimura, E.T.; Santisteban, P.; De la Vieja, A. "Regulation of thyroid oxidative state by thioredoxin reductase has a crucial role in thyroid responses to iodide excess.". Mol. Endocrinol.. 25(11): 1924-1935. (2011). (PMID: 21903721).
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  62. Riesco-Eizaguirre, G.; De la Vieja, A.; Rodríguez, I.; Miranda, S.; Martín-Duque, P.; Vassaux, G.; Santisteban, P. "Telomerase-driven expression of the sodium iodide symporter (NIS) for in vivo radioiodide treatment of cancer: a new broad-spectrum NIS-mediated antitumor approach.". J. Clin. Endocrinol. Metab.. 96(9): E1435-43. (2011). (PMID: 21697253).
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  63. Santisteban, P.; Recacha, P.; Metzger, D.E.; Zaret, K.S. "Dynamic expression of Groucho-related genes Grg1 and Grg3 in foregut endoderm and antagonism of differentiation.". Dev. Dyn.. 239(3): 980-986. (2010). (PMID: 20108349).
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  64. Riesco-Eizaguirre, G.; Rodríguez, I.; De la Vieja, A.; Costamagna, E.; Carrasco, N.; Nistal, M.; Santisteban, P. "The BRAFV600E oncogene induces transforming growth factor beta secretion leading to sodium iodide symporter repression and increased malignancy in thyroid cancer.". Cancer Res.. 69(21): 8317-8325. (2009). (PMID: 19861538).
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  65. Landa, I.; Ruiz-Llorente, S.; Montero-Conde, C.; Inglada-Pérez, L.; Schiavi, F.; Leskelä, S.; Pita, G.; Milne, R.; Maravall, J.; Ramos, I.; Andía, V.; Rodríguez-Poyo, P.; Jara-Albarrán, A.; Meoro, A.; del Peso, C.; Arribas, L.; Iglesias, P.; Caballero, J.; Serrano, J.; Picó, A.; Pomares, F.; Giménez, G.; López-Mondéjar, P.; Castello, R.; Merante-Boschin, I.; Pelizzo, M.R.; Mauricio, D.; Opocher, G.; Rodríguez-Antona, C.; González-Neira, A.; Matías-Guiu, X.; Santisteban, P.; Robledo, M. "The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.". PLoS Genet.. 5(9): e1000637. (2009). (PMID: 19730683).
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  66. García-Jiménez, C.; Santisteban, P. "Thyroid-stimulating hormone/cAMP-mediated proliferation in thyrocytes.". Expert Rev Endocrinol Metab. 3(4): 473-491. (2008). (PMID: 30290436).
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  67. Zaballos, M.A.; Garcia, B.; Santisteban, P. "Gbetagamma dimers released in response to thyrotropin activate phosphoinositide 3-kinase and regulate gene expression in thyroid cells.". Mol. Endocrinol.. 22(5): 1183-1199. (2008). (PMID: 18202153).
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  68. Riesco-Eizaguirre, G.; Santisteban, P. "[In Process Citation].". Endocrinol Nutr. 55(3): 107-110. (2008). (PMID: 22967875).
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  69. Riesco-Eizaguirre, G.; Santisteban, P. "New insights in thyroid follicular cell biology and its impact in thyroid cancer therapy.". Endocr. Relat. Cancer. 14(4): 957-977. (2007). (PMID: 18045949).
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  70. Riesco-Eizaguirre, G.; Santisteban, P. "Molecular biology of thyroid cancer initiation.". Clin Transl Oncol. 9(11): 686-693. (2007). (PMID: 18055323).
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  71. Ruiz-Llorente, S.; Montero-Conde, C.; Milne, R.L.; Moya, C.M.; Cebrián, A.; Letón, R.; Cascón, A.; Mercadillo, F.; Landa, I.; Borrego, S.; Pérez de Nanclares, G.; Alvarez-Escolá, C.; Díaz-Pérez, J.A.; Carracedo, A.; Urioste, M.; González-Neira, A.; Benítez, J.; Santisteban, P.; Dopazo, J.; Ponder, B.A.; Robledo, M.; , . "Association study of 69 genes in the ret pathway identifies low-penetrance loci in sporadic medullary thyroid carcinoma.". Cancer Res.. 67(19): 9561-9567. (2007). (PMID: 17909067).
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  72. Cuesta, I.; Zaret, K.S.; Santisteban, P. "The forkhead factor FoxE1 binds to the thyroperoxidase promoter during thyroid cell differentiation and modifies compacted chromatin structure.". Mol. Cell. Biol.. 27(20): 7302-7314. (2007). (PMID: 17709379).
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  73. García-Jiménez, C.; Santisteban, P. "TSH signalling and cancer.". Arq Bras Endocrinol Metabol. 51(5): 654-671. (2007). (PMID: 17891229).
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  74. Riesco-Eizaguirre, G.; Santisteban, P. "A perspective view of sodium iodide symporter research and its clinical implications.". Eur. J. Endocrinol.. 155(4): 495-512. (2006). (PMID: 16990649).
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  75. Vélez, M.L.; Costamagna, E.; Kimura, E.T.; Fozzatti, L.; Pellizas, C.G.; Montesinos, M.M.; Lucero, A.M.; Coleoni, A.H.; Santisteban, P.; Masini-Repiso, A.M. "Bacterial lipopolysaccharide stimulates the thyrotropin-dependent thyroglobulin gene expression at the transcriptional level by involving the transcription factors thyroid transcription factor-1 and paired box domain transcription factor 8.". Endocrinology. 147(7): 3260-3275. (2006). (PMID: 16627577).
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  76. Moya, C.M.; Perez de Nanclares, G.; Castaño, L.; Potau, N.; Bilbao, J.R.; Carrascosa, A.; Bargadá, M.; Coya, R.; Martul, P.; Vicens-Calvet, E.; Santisteban, P. "Functional study of a novel single deletion in the TITF1/NKX2.1 homeobox gene that produces congenital hypothyroidism and benign chorea but not pulmonary distress.". J. Clin. Endocrinol. Metab.. 91(5): 1832-1841. (2006). (PMID: 16507635).
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  77. Riesco-Eizaguirre, G.; Gutiérrez-Martínez, P.; García-Cabezas, M.A.; Nistal, M.; Santisteban, P. "The oncogene BRAF V600E is associated with a high risk of recurrence and less differentiated papillary thyroid carcinoma due to the impairment of Na+/I- targeting to the membrane.". Endocr. Relat. Cancer. 13(1): 257-269. (2006). (PMID: 16601293).
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  78. García-Jiménez, C.; Zaballos, M.A.; Santisteban, P. "DARPP-32 (dopamine and 3',5'-cyclic adenosine monophosphate-regulated neuronal phosphoprotein) is essential for the maintenance of thyroid differentiation.". Mol. Endocrinol.. 19(12): 3060-3072. (2005). (PMID: 16020482).
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  79. Santisteban, P.; Bernal, J. "Thyroid development and effect on the nervous system.". Rev Endocr Metab Disord. 6(3): 217-228. (2005). (PMID: 16151626).
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  80. Rivas, M.; Mellström, B.; Naranjo, J.R.; Santisteban, P. "Transcriptional repressor DREAM interacts with thyroid transcription factor-1 and regulates thyroglobulin gene expression.". J. Biol. Chem.. 279(32): 33114-33122. (2004). (PMID: 15181011).
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  81. Novials, A.; Mato, E.; Lucas, M.; Franco, C.; Rivas, M.; Santisteban, P.; Gomis, R. "Mutation at position -132 in the islet amyloid polypeptide ( IAPP) gene promoter enhances basal transcriptional activity through a new CRE-like binding site.". Diabetologia. 47(7): 1167-1174. (2004). (PMID: 15243700).
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  82. Costamagna, E.; García, B.; Santisteban, P. "The functional interaction between the paired domain transcription factor Pax8 and Smad3 is involved in transforming growth factor-beta repression of the sodium/iodide symporter gene.". J. Biol. Chem.. 279(5): 3439-3446. (2004). (PMID: 14623893).
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  83. Vargiu, P.; De Abajo, R.; Garcia-Ranea, J.A.; Valencia, A.; Santisteban, P.; Crespo, P.; Bernal, J. "The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors.". Oncogene. 23(2): 559-568. (2004). (PMID: 14724584).
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  84. Rivas, M.; Santisteban, P. "TSH-activated signaling pathways in thyroid tumorigenesis.". Mol. Cell. Endocrinol.. 213(1): 31-45. (2003). (PMID: 15062572).
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  85. García, B.; Santisteban, P. "PI3K is involved in the IGF-I inhibition of TSH-induced sodium/iodide symporter gene expression.". Mol. Endocrinol.. 16(2): 342-352. (2002). (PMID: 11818505).
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  86. Medina, D.L.; Rivas, M.; Cruz, P.; Barroso, I.; Regadera, J.; Santisteban, P. "RhoA activation promotes transformation and loss of thyroid cell differentiation interfering with thyroid transcription factor-1 activity.". Mol. Endocrinol.. 16(1): 33-44. (2002). (PMID: 11773437).
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  87. Medina, D.L.; Santisteban, P. "Thyrotropin-dependent proliferation of in vitro rat thyroid cell systems.". Eur. J. Endocrinol.. 143(2): 161-178. (2000). (PMID: 10913934).
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  88. Losada, A.; Tovar, J.A.; Xia, H.M.; Diez-Pardo, J.A.; Santisteban, P. "Down-regulation of thyroid transcription factor-1 gene expression in fetal lung hypoplasia is restored by glucocorticoids.". Endocrinology. 141(6): 2166-2173. (2000). (PMID: 10830305).
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  89. Medina, D.L.; Toro, M.J.; Santisteban, P. "Somatostatin interferes with thyrotropin-induced G1-S transition mediated by cAMP-dependent protein kinase and phosphatidylinositol 3-kinase. Involvement of RhoA and cyclin E x cyclin-dependent kinase 2 complexes.". J. Biol. Chem.. 275(20): 15549-15556. (2000). (PMID: 10809788).
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  90. Medina, D.L.; Suzuki, K.; Pietrarelli, M.; Okajima, F.; Kohn, L.D.; Santisteban, P. "Role of insulin and serum on thyrotropin regulation of thyroid transcription factor-1 and pax-8 genes expression in FRTL-5 thyroid cells.". Thyroid. 10(4): 295-303. (2000). (PMID: 10807057).
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  91. Dilla, T.; Velasco, J.A.; Medina, D.L.; González-Palacios, J.F.; Santisteban, P. "The MDM2 oncoprotein promotes apoptosis in p53-deficient human medullary thyroid carcinoma cells.". Endocrinology. 141(1): 420-429. (2000). (PMID: 10614665).
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  92. Dilla, T.; Velasco, J.A.; Medina, D.L.; Gonza Lez-Palacios, J.F.; Santisteban, P. "The MDM2 Oncoprotein Promotes Apoptosis in p53-Deficient Human Medullary Thyroid Carcinoma Cells1.". Endocrinology. 141(1): 420-429. (2000). (PMID: 28200932).
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  93. Loaiza-Pérez, A.I.; Seisdedos, M.T.; Kleiman de Pisarev, D.L.; Sancovich, H.A.; Randi, A.S.; Ferramola de Sancovich, A.M.; Santisteban, P. "Hexachlorobenzene, a dioxin-type compound, increases malic enzyme gene transcription through a mechanism involving the thyroid hormone response element.". Endocrinology. 140(9): 4142-4151. (1999). (PMID: 10465287).
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  94. Loaiza-Pe Rez, A.I.; Seisdedos, M.T.; Kleiman de Pisarev, D.L.; Sancovich, H.A.; Randi, A.S.; Ferramola de Sancovich, A.M.; Santisteban, P. "Hexachlorobenzene, a Dioxin-Type Compound, Increases Malic Enzyme Gene Transcription through a Mechanism Involving the Thyroid Hormone Response Element1.". Endocrinology. 140(9): 4142-4151. (1999). (PMID: 28201019).
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  95. Barroso, I.; Benito, B.; Garcí-Jiménez, C.; Hernández, A.; Obregón, M.J.; Santisteban, P. "Norepinephrine, tri-iodothyronine and insulin upregulate glyceraldehyde-3-phosphate dehydrogenase mRNA during Brown adipocyte differentiation.". Eur. J. Endocrinol.. 141(2): 169-179. (1999). (PMID: 10427161).
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  96. Losada, A.; Xia, H.; Migliazza, L.; Diez-Pardo, J.A.; Santisteban, P.; Tovar, J.A. "Lung hypoplasia caused by nitrofen is mediated by down-regulation of thyroid transcription factor TTF-1.". Pediatr. Surg. Int.. 15(3-4): 188-191. (1999). (PMID: 10370019).
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  97. Barroso, I.; Santisteban, P. "Insulin-induced early growth response gene (Egr-1) mediates a short term repression of rat malic enzyme gene transcription.". J. Biol. Chem.. 274(25): 17997-18004. (1999). (PMID: 10364249).
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  98. Ortiz, L.; Aza-Blanc, P.; Zannini, M.; Cato, A.C.; Santisteban, P. "The interaction between the forkhead thyroid transcription factor TTF-2 and the constitutive factor CTF/NF-1 is required for efficient hormonal regulation of the thyroperoxidase gene transcription.". J. Biol. Chem.. 274(21): 15213-15221. (1999). (PMID: 10329730).
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  99. Ros, P.; Rossi, D.L.; Acebrón, A.; Santisteban, P. "Thyroid-specific gene expression in the multi-step process of thyroid carcinogenesis.". Biochimie. 81(4): 389-396. (1999). (PMID: 10401674).
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  100. Medina, D.L.; Velasco, J.A.; Santisteban, P. "Somatostatin is expressed in FRTL-5 thyroid cells and prevents thyrotropin-mediated down-regulation of the cyclin-dependent kinase inhibitor p27kip1.". Endocrinology. 140(1): 87-95. (1999). (PMID: 9886811).
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  101. Velasco, J.A.; Acebrón, A.; Zannini, M.; Martín-Pérez, J.; Di Lauro, R.; Santisteban, P. "Ha-ras interference with thyroid cell differentiation is associated with a down-regulation of thyroid transcription factor-1 phosphorylation.". Endocrinology. 139(6): 2796-2802. (1998). (PMID: 9607786).
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  102. Cruz, F.; Scott, S.R.; Barroso, I.; Santisteban, P.; Cerdán, S. "Ontogeny and cellular localization of the pyruvate recycling system in rat brain.". J. Neurochem.. 70(6): 2613-2619. (1998). (PMID: 9603228).
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  103. Mato, E.; Santisteban, P.; Chowen, J.A.; Fornas, O.; Bouwens, M.; Puig-Domingo, M.; Argente, J.; Webb, S.M. "Circannual somatostatin gene and somatostatin receptor gene expression in the early post-natal rat pineal gland.". Neuroendocrinology. 66(5): 368-374. (1997). (PMID: 9387856).
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  104. Velasco, J.A.; Medina, D.L.; Romero, J.; Mato, M.E.; Santisteban, P. "Introduction of p53 induces cell-cycle arrest in p53-deficient human medullary-thyroid-carcinoma cells.". Int. J. Cancer. 73(3): 449-455. (1997). (PMID: 9359494).
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  105. Ortiz, L.; Zannini, M.; Di Lauro, R.; Santisteban, P. "Transcriptional control of the forkhead thyroid transcription factor TTF-2 by thyrotropin, insulin, and insulin-like growth factor I.". J. Biol. Chem.. 272(37): 23334-23339. (1997). (PMID: 9287345).
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  106. de la Vieja, A.; Calero, M.; Santisteban, P.; Lamas, L. "Identification and quantitation of iodotyrosines and iodothyronines in proteins using high-performance liquid chromatography by photodiode-array ultraviolet-visible detection.". J. Chromatogr. B Biomed. Sci. Appl.. 688(1): 143-149. (1997). (PMID: 9029324).
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  107. Baggio, M.C.; Medeiros-Neto, G.; Osawa, Y.; Nguyen, N.Y.; Santisteban, P.; Knobel, M.; Groliman, E.E. "Amino Acid Composition of Proteins Extracted from Endemic Goiter Glands.". Endocr. Pathol.. 7(2): 137-143. (1996). (PMID: 12114641).
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  108. Zannini, M.; Acebron, A.; De Felice, M.; Arnone, M.I.; Martin-Pérez, J.; Santisteban, P.; Di Lauro, R. "Mapping and functional role of phosphorylation sites in the thyroid transcription factor-1 (TTF-1).". J. Biol. Chem.. 271(4): 2249-2254. (1996). (PMID: 8567686).
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  109. Rossi, D.L.; Acebrón, A.; Santisteban, P. "Function of the homeo and paired domain proteins TTF-1 and Pax-8 in thyroid cell proliferation.". J. Biol. Chem.. 270(39): 23139-23142. (1995). (PMID: 7559458).
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  110. Acebrón, A.; Aza-Blanc, P.; Rossi, D.L.; Lamas, L.; Santisteban, P. "Congenital human thyroglobulin defect due to low expression of the thyroid-specific transcription factor TTF-1.". J. Clin. Invest.. 96(2): 781-785. (1995). (PMID: 7635972).
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  111. Rodríguez, M.; Rodríguez, F.; Jolin, T.; Santisteban, P. "Comparative effects of food restriction, fasting, diabetes and thyroidectomy on growth hormone and thyrotropin gene expression in the rat pituitary.". Eur. J. Endocrinol.. 133(1): 110-116. (1995). (PMID: 7627331).
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  112. García-Jiménez, C.; Benito, B.; Jolin, T.; Santisteban, P. "Insulin regulation of malic enzyme gene expression in rat liver: evidence for nuclear proteins that bind to two putative insulin response elements.". Mol. Endocrinol.. 8(10): 1361-1369. (1994). (PMID: 7854353).
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  113. Aza-Blanc, P.; Di Lauro, R.; Santisteban, P. "Identification of a cis-regulatory element and a thyroid-specific nuclear factor mediating the hormonal regulation of rat thyroid peroxidase promoter activity.". Mol. Endocrinol.. 7(10): 1297-1306. (1993). (PMID: 8264661).
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  114. Mato, E.; Santisteban, P.; Viader, M.; Capellá, G.; Fornas, O.; Puig-Domingo, M.; Webb, S.M. "Expression of somatostatin in rat pineal cells in culture.". J. Pineal Res.. 15(1): 43-45. (1993). (PMID: 7901362).
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  115. Hernandez, A.; Garcia-Jimenez, C.; Santisteban, P.; Obregon, M.J. "Regulation of malic-enzyme-gene expression by cAMP and retinoic acid in differentiating brown adipocytes.". Eur. J. Biochem.. 215(2): 285-290. (1993). (PMID: 8393790).
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  116. García-Jimenez, C.; Hernández, A.; Obregón, M.J.; Santisteban, P. "Malic enzyme gene expression in differentiating brown adipocytes: regulation by insulin and triiodothyronine.". Endocrinology. 132(4): 1537-1543. (1993). (PMID: 8462451).
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  117. Santisteban, P.; Acebrón, A.; Polycarpou-Schwarz, M.; Di Lauro, R. "Insulin and insulin-like growth factor I regulate a thyroid-specific nuclear protein that binds to the thyroglobulin promoter.". Mol. Endocrinol.. 6(8): 1310-1317. (1992). (PMID: 1406708).
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  118. Rodríguez, M.; Santisteban, P.; Acebrón, A.; Hernandez, L.C.; del Valle, M.; Jolin, T. "Expression of thyroglobulin gene in maternal and fetal thyroid in rats.". Endocrinology. 131(1): 415-422. (1992). (PMID: 1612022).
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  119. Bedo, G.; Santisteban, P.; Jolin, T.; Aranda, A. "Expression of the growth hormone gene and the pituitary-specific transcription factor GHF-1 in diabetic rats.". Mol. Endocrinol.. 5(11): 1730-1739. (1991). (PMID: 1779974).
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  120. Doi, S.; Shifrin, S.; Santisteban, P.; Montali, R.J.; Schiller, C.; Bush, M.; Grollman, E.F. "Familial goiter in bongo antelope (Tragelaphus eurycerus).". Endocrinology. 127(2): 857-864. (1990). (PMID: 2373058).
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  121. Zarrilli, R.; Oates, E.L.; McBride, O.W.; Lerman, M.I.; Chan, J.Y.; Santisteban, P.; Ursini, M.V.; Notkins, A.L.; Kohn, L.D. "Sequence and chromosomal assignment of a novel cDNA identified by immunoscreening of a thyroid expression library: similarity to a family of mitochondrial solute carrier proteins.". Mol. Endocrinol.. 3(9): 1498-1505. (1989). (PMID: 2575220).
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  122. Hargreaves, A.J.; Lamas, L.; Santisteban, P.; Avila, J. "Subcellular localization of iodinated thyroid tubulin.". Biosci. Rep.. 9(3): 375-382. (1989). (PMID: 2775864).
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  123. Bedo, G.; Santisteban, P.; Aranda, A. "Retinoic acid regulates growth hormone gene expression.". Nature. 339(6221): 231-234. (1989). (PMID: 2716850).
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  124. Chan, J.Y.; Lerman, M.I.; Prabhakar, B.S.; Isozaki, O.; Santisteban, P.; Kuppers, R.C.; Oates, E.L.; Notkins, A.L.; Kohn, L.D. "Cloning and characterization of a cDNA that encodes a 70-kDa novel human thyroid autoantigen.". J. Biol. Chem.. 264(7): 3651-3654. (1989). (PMID: 2917966).
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  125. Isozaki, O.; Santisteban, P.; Chan, J.; Grollman, E.; Kohn, L. "Insulin and insulin-like growth factor-I (IGF-I) regulate differentiation as well as growth in FRTL-5 cells.". Acta Endocrinol Suppl (Copenh). 281(): 288-292. (1987). (PMID: 3303791).
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  126. Grollman, E.F.; Bone, E.; Chan, J.; Corda, D.; Isozaki, O.; Marcocci, C.; Santisteban, P.; Kohn, L.D. "TSH and biogenic amine signals in the regulation of thyroid function: independent regulation by protein kinase C and G proteins.". Acta Endocrinol Suppl (Copenh). 281(): 199-202. (1987). (PMID: 3113150).
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  127. Chan, J.; Santisteban, P.; De Luca, M.; Isozaki, O.; Grollman, E.; Kohn, L. "TSH receptor structure.". Acta Endocrinol Suppl (Copenh). 281(): 166-172. (1987). (PMID: 3475898).
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  128. Consiglio, E.; Acquaviva, A.M.; Formisano, S.; Liguoro, D.; Gallo, A.; Vittorio, T.; Santisteban, P.; De Luca, M.; Shifrin, S.; Yeh, H.J. "Characterization of phosphate residues on thyroglobulin.". J. Biol. Chem.. 262(21): 10304-10314. (1987). (PMID: 2440862).
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  129. Marcocci, C.; Luini, A.; Santisteban, P.; Grollman, E.F. "Norepinephrine and thyrotropin stimulation of iodide efflux in FRTL-5 thyroid cells involves metabolites of arachidonic acid and is associated with the iodination of thyroglobulin.". Endocrinology. 120(3): 1127-1133. (1987). (PMID: 3100285).
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  130. Santisteban, P.; Kohn, L.D.; Di Lauro, R. "Thyroglobulin gene expression is regulated by insulin and insulin-like growth factor I, as well as thyrotropin, in FRTL-5 thyroid cells.". J. Biol. Chem.. 262(9): 4048-4052. (1987). (PMID: 3549723).
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  131. Kohn, L.D.; Alvarez, F.; Marcocci, C.; Kohn, A.D.; Corda, D.; Hoffman, W.E.; Tombaccini, D.; Valente, W.A.; de Luca, M.; Santisteban, P. "Monoclonal antibody studies defining the origin and properties of autoantibodies in Graves' disease.". Ann. N. Y. Acad. Sci.. 475(): 157-173. (1986). (PMID: 3491561).
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  132. Grollman, E.F.; Smolar, A.; Ommaya, A.; Tombaccini, D.; Santisteban, P. "Iodine suppression of iodide uptake in FRTL-5 thyroid cells.". Endocrinology. 118(6): 2477-2482. (1986). (PMID: 3009160).
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  133. Lamas, L.; Santisteban, P.; Turmo, C.; Seguido, A.M. "Evidence, by in vitro enzymatic iodination of thyroglobulin, that the efficiency of coupling is determined by the initial iodide concentration.". Endocrinology. 118(5): 2131-2136. (1986). (PMID: 3698909).
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  134. Santisteban, P.; Hargreaves, A.J.; Cano, J.; Avila, J.; Lamas, L. "Effects of high doses of iodide on thyroid secretion: evidence for the presence of iodinated membrane tubulin.". Endocrinology. 117(2): 607-612. (1985). (PMID: 4017949).
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  135. Obregón, M.J.; Santisteban, P.; Rodríguez-Peña, A.; Pascual, A.; Cartagena, P.; Ruiz-Marcos, A.; Lamas, L.; Escobar del Rey, F.; Morreale de Escobar, G. "Cerebral hypothyroidism in rats with adult-onset iodine deficiency.". Endocrinology. 115(2): 614-624. (1984). (PMID: 6745172).
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  136. Santisteban, P.; Obregon, M.J.; Rodriguez-Peña, A.; Lamas, L.; Del Rey, F.E.; De Escobar, G.M. "Are iodine-deficient rats euthyroid?". Endocrinology. 110(5): 1780-1789. (1982). (PMID: 6804212).
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  137. van den Hove-Vandenbroucke, M.F.; Santisteban, P.; Couvreur, M.; Obregon, M.J.; Lamas, L. "Involution of rat iodoprive hyperplastic goiter: effect of iodide administration on thyroid function and lysosomal properties.". Endocrinology. 110(5): 1812-1818. (1982). (PMID: 6176441).
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  138. Santisteban, P.; Lamas, L. "The effect of varying iodine content on the proteolytic activity of rat thyroid lysosomes.". Acta Endocrinol.. 98(4): 556-563. (1981). (PMID: 6272517).
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  139. Lamas, L.; Santisteban, P. "Re-evaluation of some factors affecting the stability of rat thyroglobulin.". Biochim. Biophys. Acta. 621(2): 265-272. (1980). (PMID: 7353044).
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