Sereno, M.; Gutiérrez-Gutiérrez, G.; Rubio, J.M.; Apellániz-Ruiz, M.; Sánchez-Barroso, L.; Casado, E.; Falagan, S.; López-Gómez, M.; Merino, M.; Gómez-Raposo, C.; Rodriguez-Salas, N.; Tébar, F.Z.; Rodríguez-Antona, C. "Genetic polymorphisms of SCN9A are associated with oxaliplatin-induced neuropathy.". BMC Cancer. 17(1): 63. (2017). (PMID: 28103821).
RESULTS We found that SCN9A rs6746030 was associated with protection for severe neuropathy (OR = 0.39, 95% CI = 0.16-0.96; p = 0.041). Multivariate analysis adjusting for diabetes provided similar results (p = 0.036). No significant differences in neuropathy risk were detected for rs74401238 and rs41268673.
CONCLUSION SCN9A rs6746030 was associated with protection for severe oxaliplatin-induced peripheral neuropathy. The validation of this exploratory study is ongoing in an independent series.
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López-Gómez, M.; Casado, E.; Muñoz, M.; Alcalá, S.; Moreno-Rubio, J.; D'Errico, G.; Jiménez-Gordo, A.M.; Salinas, S.; Sainz, B. "Current evidence for cancer stem cells in gastrointestinal tumors and future research perspectives.". Crit. Rev. Oncol. Hematol.. 107(): 54-71. (2016). (PMID: 27823652).
Sereno, M.; Gutiérrez-Gutiérrez, G.; Gómez-Raposo, C.; López-Gómez, M.; Merino-Salvador, M.; Tébar, F.Z.; Rodriguez-Antona, C.; Casado, E. "Oxaliplatin induced-neuropathy in digestive tumors.". Crit Rev Oncol Hematol. 89(1): 166-178. (2014). (PMID: 24029604).
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Cejas, P.; García-Cabezas, M.A.; Casado, E.; Belda-Iniesta, C.; De Castro, J.; Fresno, J.A.; Sereno, M.; Barriuso, J.; Espinosa, E.; Zamora, P.; Feliu, J.; Redondo, A.; Hardisson, D.A.; Renart, J.; González-Barón, M. "Phospholipid hydroperoxide glutathione peroxidase (PHGPx) expression is downregulated in poorly differentiated breast invasive ductal carcinoma.". Free Radic. Res.. 41(6): 681-687. (2007). (PMID: 17516241).
Belda-Iniesta, C.; de Castro Carpeño, J.; Casado Sáenz, E.; Cejas Guerrero, P.; Perona, R.; González Barón, M. "Molecular biology of malignant gliomas.". Clin Transl Oncol. 8(9): 635-641. (2006). (PMID: 17005465).
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