19 mayo | 2025 Effect of lipotoxic hepatocyte-derived extracellular vesicles in pancreas inflammation: essential role of macrophage TLR4 in beta cell functionality. Alén, R , Garcia-Martinez, I , Cobo-Vuilleumier, N, Fernández-Millán, E, Gallardo-Villanueva, P, Ferreira, V , Izquierdo, M , Moro, MÁ, Lizasoain, I, Nieto, N, Gauthier, BR, Valverde, ÁM . Diabetologia (PMID: 40387904) (doi:10.1007/s00125-025-06445-z)
6 mayo | 2025 Imaging the immune synapse: Three-dimensional analysis of the immune synapse. Ruiz-Navarro, J , Blázquez-Cucharero, S, Calvo, V , Izquierdo, M . Methods Cell Biol - 193 : 15-37 (PMID: 39919840) (doi:10.1016/bs.mcb.2023.04.003)
31 oct | 2024 Formin-like 1β phosphorylation at S1086 is necessary for secretory polarized traffic of exosomes at the immune synapse in Jurkat T lymphocytes. Ruiz-Navarro, J , Fernández-Hermira, S , Sanz-Fernández, I , Barbeito, P , Navarro-Zapata, A, Pérez-Martínez, A, Garcia-Gonzalo, FR , Calvo, V , Izquierdo Pastor, M . Elife - 13 (PMID: 39479958) (doi:10.7554/eLife.96942)
3 oct | 2024 Editorial: Structure and function of the immunological and redirecting artificial synapses and their clinical implications. Izquierdo, M , Ruiz-Navarro, J , Baldari, CT, Roda-Navarro, P. Front Immunol - 15 : 1497118 (PMID: 39421740) (doi:10.3389/fimmu.2024.1497118)
8 mayo | 2024 Newer generations of multi-target CAR and STAb-T immunotherapeutics: NEXT CART Consortium as a cooperative effort to overcome current limitations. Martín-Antonio, B, Blanco, B, González-Murillo, Á, Hidalgo, L, Minguillón, J, Pérez-Chacón, G , , , , , , . Front Immunol - 15 : 1386856 (PMID: 38779672) (doi:10.3389/fimmu.2024.1386856)
1 dic | 2023 Extracellular vesicles and microvilli in the immune synapse. Ruiz-Navarro, J , Calvo, V , Izquierdo, M . Front Immunol - 14 : 1324557 (PMID: 38268920) (doi:10.3389/fimmu.2023.1324557)
18 oct | 2023 NKG2D-CAR memory T cells target pediatric T-cell acute lymphoblastic leukemia in vitro and in vivo but fail to eliminate leukemia initiating cells. Ibáñez-Navarro, M, Fernández, A, Escudero, A, Esteso, G, Campos-Silva, C, Navarro-Aguadero, MÁ, Leivas, A, Caracuel, BR, Rodríguez-Antolín, C, Ortiz, A, Navarro-Zapata, A, Mestre-Durán, C, Izquierdo, M , Balaguer-Pérez, M, Ferreras, C, Martínez-López, J, Valés-Gómez, M, Pérez-Martínez, A, Fernández, L. Front Immunol - 14 : 1187665 (PMID: 37928520) (doi:10.3389/fimmu.2023.1187665)
1 ago | 2023 Saturated fatty acid-enriched small extracellular vesicles mediate a crosstalk inducing liver inflammation and hepatocyte insulin resistance. Garcia-Martinez, I , Alen, R , Pereira, L, Povo-Retana, A , Astudillo, AM, Hitos, AB , Gomez-Hurtado, I, Lopez-Collazo, E, Boscá, L , Francés, R, Lizasoain, I, Moro, MÁ, Balsinde, J, Izquierdo, M , Valverde, ÁM . JHEP Rep - 5 (8) : 100756 (PMID: 37360906) (doi:10.1016/j.jhepr.2023.100756)
13 jul | 2023 End-binding protein 1 regulates the metabolic fate of CD4+ T lymphoblasts and Jurkat T cells and the organization of the mitochondrial network. Gómez-Morón, Á, Requena, S, Pertusa, C, Lozano-Prieto, M, Calzada-Fraile, D, Scagnetti, C, Sánchez-García, I, Calero-García, AA, Izquierdo, M , Martín-Cófreces, NB. Front Immunol - 14 : 1197289 (PMID: 37520527) (doi:10.3389/fimmu.2023.1197289)
1 ene | 2023 Analysis of centrosomal area actin reorganization and centrosome polarization upon lymphocyte activation at the immunological synapse. Fernández-Hermira, S , Sanz-Fernández, I , Botas, M , Calvo, V , Izquierdo, M . Methods Cell Biol - 173 : 15-32 (PMID: 36653081) (doi:10.1016/bs.mcb.2021.11.002)
5 sep | 2022 Multiple ciliary localization signals control INPP5E ciliary targeting. Cilleros-Rodriguez, D , Martin-Morales, R , Barbeito, P , Deb Roy, A, Loukil, A, Sierra-Rodero, B , Herranz, G , Pampliega, O, Redrejo-Rodriguez, M , Goetz, SC, Izquierdo, M , Inoue, T, Garcia-Gonzalo, FR . Elife - 11 (PMID: 36063381) (doi:10.7554/eLife.78383)
24 feb | 2022 T Lymphocyte and CAR-T Cell-Derived Extracellular Vesicles and Their Applications in Cancer Therapy. Calvo, V , Izquierdo, M . Cells - 11 (5) (PMID: 35269412) (doi:10.3390/cells11050790)
4 feb | 2021 Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunological Synapse. Calvo, V , Izquierdo, M . Front Cell Dev Biol - 9 : 629097 (PMID: 33614660) (doi:10.3389/fcell.2021.629097)
19 jun | 2020 Actin reorganization at the centrosomal area and the immune synapse regulates polarized secretory traffic of multivesicular bodies in T lymphocytes. Bello-Gamboa, A , Velasco, M , Moreno, S , Herranz, G , Ilie, R, Huetos, S, Dávila, S , Sánchez, A , Bernardino De La Serna, J, Calvo, V , Izquierdo, M . J Extracell Vesicles - 9 (1) : 1759926 (PMID: 32939232) (doi:10.1080/20013078.2020.1759926)
10 abr | 2020 Inducible Polarized Secretion of Exosomes in T and B Lymphocytes. Calvo, V , Izquierdo, M . Int J Mol Sci - 21 (7) (PMID: 32290050) (doi:10.3390/ijms21072631)
26 dic | 2019 Imaging the Human Immunological Synapse. Bello-Gamboa, A , Bello-Gamboa, A , Izquierdo, JM , Izquierdo, JM , Velasco, M , Velasco, M , Moreno, S , Moreno, S , Garrido, A , Garrido, A , Meyers, L , Meyers, L , Palomino, JC, Palomino, JC, Calvo, V , Calvo, V , Izquierdo, M , Izquierdo, M . J Vis Exp (PMID: 31929507) (doi:10.3791/60312)
26 abr | 2019 Protein Kinase C δ Regulates the Depletion of Actin at the Immunological Synapse Required for Polarized Exosome Secretion by T Cells. Herranz, G , Aguilera, P , Dávila, S , Sánchez, A , Stancu, B , Gómez, J , Fernández-Moreno, D , de Martín, R , Quintanilla, M , Fernández, T , Rodríguez-Silvestre, P , Márquez-Expósito, L , Bello-Gamboa, A , Fraile-Ramos, A, Calvo, V , Izquierdo, M . Frontiers in immunology - 10 : 851 (PMID: 31105694) (doi:10.3389/fimmu.2019.00851)
15 mayo | 2018 Role of Microvesicles in the Spread of Herpes Simplex Virus 1 in Oligodendrocytic Cells. Bello-Morales, R, Praena, B, de la Nuez, C, Rejas, MT, Guerra, M, Galán-Ganga, M , Izquierdo, M , Calvo, V , Krummenacher, C, López-Guerrero, JA. J. Virol. - 92 (10) (PMID: 29514899) (doi:10.1128/JVI.00088-18)
6 abr | 2018 Imaging Polarized Secretory Traffic at the Immune Synapse in Living T Lymphocytes. Calvo, V , Izquierdo, M . Front Immunol - 9 : 684 (PMID: 29681902) (doi:10.3389/fimmu.2018.00684)
1 mayo | 2017 Exosomes from eosinophils autoregulate and promote eosinophil functions. Cañas, JA, Sastre, B, Mazzeo, C , Fernández-Nieto, M, Rodrigo-Muñoz, JM, González-Guerra, A, Izquierdo, M , Barranco, P, Quirce, S, Sastre, J, Del Pozo, V. J. Leukoc. Biol. - 101 (5) : 1191-1199 (PMID: 28096299) (doi:10.1189/jlb.3AB0516-233RR)
1 ene | 2016 Protein kinase D1/2 is involved in the maturation of multivesicular bodies and secretion of exosomes in T and B lymphocytes. Mazzeo, C , Calvo, V , Alonso, R, Mérida, I, Izquierdo, M . Cell Death Differ. - 23 (1) : 99-9109 (PMID: 26045048) (doi:10.1038/cdd.2015.72)
8 jun | 2015 Exosome secretion by eosinophils: A possible role in asthma pathogenesis. Mazzeo, C , Cañas, JA, Zafra, MP, Rojas Marco, A, Fernández-Nieto, M, Sanz, V, Mittelbrunn, M, Izquierdo, M , Baixaulli, F, Sastre, J, Del Pozo, V. J. Allergy Clin. Immunol. - 135 (6) : 1603-1613 (PMID: 25617225) (doi:10.1016/j.jaci.2014.11.026)
15 abr | 2013 Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses. Través, PG , Pimentel-Santillana, M , Carrasquero, LM, Pérez-Sen, R, Delicado, EG, Luque, A, Izquierdo, M , Martín-Sanz, P , Miras-Portugal, MT, Boscá, L . J. Immunol. - 190 (8) : 4226-4235 (PMID: 23479225) (doi:10.4049/jimmunol.1203029)
1 jul | 2011 Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes. Alonso, R, Mazzeo, C , Rodriguez, MC, Marsh, M, Fraile-Ramos, A, Calvo, V , Avila-Flores, A, Merida, I, Izquierdo, M . Cell Death Differ. - 18 (7) : 1161-1173 (PMID: 21252909) (doi:10.1038/cdd.2010.184)
2 feb | 2007 A new role of diacylglycerol kinase alpha on the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes. Alonso, R, Mazzeo, C , Mérida, I, Izquierdo, M . Biochimie - 89 (2) : 213-221 (PMID: 16989932) (doi:10.1016/j.biochi.2006.07.018)
5 ago | 2005 Diacylglycerol kinase alpha regulates the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes. Alonso, R, Rodríguez, MC, Pindado, J , Merino, E, Mérida, I, Izquierdo, M . J Biol Chem - 280 (31) : 28439-28450 (PMID: 15870081) (doi:10.1074/jbc.M501112200)
1 nov | 2003 Exacerbated inflammatory responses in transgenic mice expressing an inhibitor of apoptosis protein (OpIAP). Robles, MS, Leonardo, E, Criado, LM, Izquierdo, M , Martínez-A, C. Cell Death Differ. - 10 (11) : 1226-1233 (PMID: 14576774) (doi:10.1038/sj.cdd.4401297)
18 abr | 2003 Calcium influx through receptor-operated channel induces mitochondria-triggered paraptotic cell death. Jambrina, E, Alonso, R, Alcalde, M, del Carmen Rodríguez, M, Serrano, A, Martínez-A, C, García-Sancho, J, Izquierdo, M . J. Biol. Chem. - 278 (16) : 14134-14145 (PMID: 12571238) (doi:10.1074/jbc.M211388200)
19 dic | 2002 Degradation of cellular mRNA is a general early apoptosis-induced event. Del Prete, MJ, Robles, MS, Guáo, A, Martínez-A, C, Izquierdo, M , Garcia-Sanz, JA. FASEB J. - 16 (14) : 2003-2005 (PMID: 12397088) (doi:10.1096/fj.02-0392fje)
15 feb | 2002 Inhibitor of apoptosis protein from Orgyia pseudotsugata nuclear polyhedrosis virus provides a costimulatory signal required for optimal proliferation of developing thymocytes. Robles, MS, Leonardo, E, Criado, LM, Izquierdo, M , Martínez-A, C. J. Immunol. - 168 (4) : 1770-1779 (PMID: 11823509)
2 abr | 2001 Role of diacylglycerol kinase alpha in the attenuation of receptor signaling. Sanjuán, MA, Jones, DR, Izquierdo, M , Mérida, I. J. Cell Biol. - 153 (1) : 207-220 (PMID: 11285286)
1 nov | 1999 Protein kinase C inhibits CD95 (Fas/APO-1)-mediated apoptosis by at least two different mechanisms in Jurkat T cells. Ruiz-Ruiz, C, Robledo, G, Font, J, Izquierdo, M , López-Rivas, A. J. Immunol. - 163 (9) : 4737-4746 (PMID: 10528172)
4 ene | 1999 Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor. Izquierdo, M , Grandien, A, Criado, LM, Robles, S, Leonardo, E, Albar, JP, de Buitrago, GG, Martínez-A, C. EMBO J. - 18 (1) : 156-166 (PMID: 9878059) (doi:10.1093/emboj/18.1.156)
1 jul | 1997 CD38 ligation results in activation of the Raf-1/mitogen-activated protein kinase and the CD3-zeta/zeta-associated protein-70 signaling pathways in Jurkat T lymphocytes. Zubiaur, M, Izquierdo, M , Terhorst, C, Malavasi, F, Sancho, J. J. Immunol. - 159 (1) : 193-205 (PMID: 9200455)
1 jun | 1997 Activation of protein kinase C attenuates early signals in Fas-mediated apoptosis. Ruiz-Ruiz, MC, Izquierdo, M , de Murcia, G, López-Rivas, A. Eur. J. Immunol. - 27 (6) : 1442-1450 (PMID: 9209497) (doi:10.1002/eji.1830270622)
1 jul | 1996 Stimulation of phosphatidylinositol turnover is a key event for Fas-dependent, activation-induced apoptosis in human T lymphocytes. Izquierdo, M , Ruiz-Ruiz, MC, López-Rivas, A. J. Immunol. - 157 (1) : 21-28 (PMID: 8683117)
1 sep | 1995 Activation-induced apoptosis in Jurkat cells through a myc-independent mechanism. Ruiz-Ruiz, MC, Oliver, FJ, Izquierdo, M , López-Rivas, A. Mol. Immunol. - 32 (13) : 947-955 (PMID: 7477000)
19 mayo | 1995 Regulation and function of p21ras in T lymphocytes. Pastor, MI , Woodrow, M, Cantrell, D. Cancer Surv. - 22 : 75-83 (PMID: 7720060)
1 mar | 1995 The regulation and function of p21ras during T-cell activation and growth. Izquierdo Pastor, M , Reif, K, Cantrell, D. Immunol. Today - 16 (3) : 159-164 (PMID: 7718090)
2 dic | 1994 Signal transduction by the T-cell antigen receptor: regulation and function of p21ras and PtdIns-3 kinase. Cantrell, D, Izquierdo-Pastor, M , Reif, K, Woodrow, M. Chem. Immunol. - 59 : 115-127 (PMID: 7945924)
1 dic | 1994 The regulation and function of p21ras in signal transduction by the T cell antigen receptor. Cantrell, D, Pastor, MI , Woodrow, M. Adv. Exp. Med. Biol. - 365 : 73-79 (PMID: 7887315)
1 oct | 1994 The role of protein kinase C in the regulation of extracellular signal-regulated kinase by the T cell antigen receptor. Izquierdo, M , Leevers, SJ, Williams, DH, Marshall, CJ, Weiss, A, Cantrell, D. Eur. J. Immunol. - 24 (10) : 2462-2468 (PMID: 7925576) (doi:10.1002/eji.1830241031)
1 jul | 1994 The role of Raf-1 in the regulation of extracellular signal-regulated kinase 2 by the T cell antigen receptor. Izquierdo, M , Bowden, S, Cantrell, D. J. Exp. Med. - 180 (1) : 401-406 (PMID: 8006597)
1 oct | 1993 p21ras couples the T cell antigen receptor to extracellular signal-regulated kinase 2 in T lymphocytes. Izquierdo, M , Leevers, SJ, Marshall, CJ, Cantrell, D. J. Exp. Med. - 178 (4) : 1199-1208 (PMID: 8376929)
1 oct | 1993 Regulation of PtdIns-3-kinase and the guanine nucleotide binding proteins p21ras during signal transduction by the T cell antigen receptor and the interleukin-2 receptor. Cantrell, DA, Izquierdo, M , Reif, K, Woodrow, M. Semin. Immunol. - 5 (5) : 319-326 (PMID: 8260648) (doi:10.1006/smim.1993.1038)
1 ene | 1993 Protein tyrosine kinases couple the interleukin-2 receptor to p21ras. Izquierdo, M , Cantrell, DA. Eur. J. Immunol. - 23 (1) : 131-135 (PMID: 8419163) (doi:10.1002/eji.1830230121)
19 nov | 1992 T lymphocyte activation signals. Cantrell, DA, Graves, JD, Izquierdo, M , Lucas, S, Downward, J. Ciba Found. Symp. - 164 : 208-18; discussion 218-22 (PMID: 1395932)
1 sep | 1992 T-cell activation. Izquierdo, M , Cantrell, DA. Trends Cell Biol. - 2 (9) : 268-271 (PMID: 14731519)
1 jul | 1992 Role of protein kinase C in T-cell antigen receptor regulation of p21ras: evidence that two p21ras regulatory pathways coexist in T cells. Izquierdo, M , Downward, J, Graves, JD, Cantrell, DA. Mol. Cell. Biol. - 12 (7) : 3305-3312 (PMID: 1620132)
15 abr | 1992 The growth factor IL-2 activates p21ras proteins in normal human T lymphocytes. Graves, JD, Downward, J, Izquierdo-Pastor, M , Rayter, S, Warne, PH, Cantrell, DA. J. Immunol. - 148 (8) : 2417-2422 (PMID: 1532814)
1 mar | 1992 Analysis of different protein kinase C-dependent events in T cells from allogeneic bone marrow transplantation recipients. Balboa, MA, Izquierdo, M , Sánchez-Madrid, F, Fernández-Rañada, JM, López-Botet, M. Clin. Exp. Immunol. - 87 (3) : 478-484 (PMID: 1544233)
1 mar | 1992 Interleukin (IL)-2 activation of p21ras in murine myeloid cells transfected with human IL-2 receptor beta chain. Izquierdo, M , Downward, J, Otani, H, Leonard, WJ, Cantrell, DA. Eur. J. Immunol. - 22 (3) : 817-821 (PMID: 1547824) (doi:10.1002/eji.1830220328)
15 jul | 1991 A novel functional cell surface dimer (Kp43) expressed by natural killer cells and gamma/delta TCR+ T lymphocytes. II. Modulation of natural killer cytotoxicity by anti-Kp43 monoclonal antibody. Aramburu, J, Balboa, MA, Izquierdo, M , López-Botet, M. J. Immunol. - 147 (2) : 714-721 (PMID: 1830071)
1 feb | 1991 Autonomous roles for the cytoplasmic domains of the CD2 and CD4 T cell surface antigens. Beyers, AD, Davis, SJ, Cantrell, DA, Izquierdo, M , Williams, AF. EMBO J. - 10 (2) : 377-385 (PMID: 1671352)
1 oct | 1990 Relation between the increase of circulating CD3+ CD57+ lymphocytes and T cell dysfunction in recipients of bone marrow transplantation. Izquierdo, M , Balboa, MA, Fernández-Rañada, JM, Figuera, A, Torres, A, Iriondo, A, López-Botet, M. Clin. Exp. Immunol. - 82 (1) : 145-150 (PMID: 1698579)
1 oct | 1989 Deficient protein kinase C-dependent Na+/H+ exchanger activity in T cells from bone marrow transplantation recipients. Izquierdo, M , Redondo, JM, Balboa, MA, López-Rivas, A, Cragoe, EJ, Vázquez, L, Fernández-Rañada, JM, López-Botet, M. J. Immunol. - 143 (7) : 2185-2192 (PMID: 2550550)
15 abr | 1989 High toxic efficiency of ricin immunotoxins specific for the T-cell antigen receptor of a human leukemia T-cell line. Izquierdo, M , Balboa, MA, Lamana, ML, López-Botet, M. Int. J. Cancer - 43 (4) : 697-702 (PMID: 2467887)
1 nov | 1988 Selective T cell subset depletion with anti-CD4 and anti-CD8 intact ricin immunotoxins. Izquierdo, M , Balboa, MA, Figuera, A, López-Botet, M. Clin. Exp. Immunol. - 74 (2) : 300-304 (PMID: 3265657)
1 ago | 1987 Defective interleukin 2 receptor expression is associated with the T cell disfunction subsequent to bone marrow transplantation. López-Botet, M, De Landazuri, MO, Izquierdo, M , Ramirez, A, Cámara, R, Fernández-Rañada, J. Eur. J. Immunol. - 17 (8) : 1167-1174 (PMID: 3113980) (doi:10.1002/eji.1830170814)