1 abr | 2021 Mitochondrial LonP1 protease is implicated in the degradation of unstable Parkinson's disease-associated DJ-1/PARK 7 missense mutants. Sánchez-Lanzas, R , Castaño, JG . Sci Rep - 11 (1) : 7320 (PMID: 33795807) (doi:10.1038/s41598-021-86847-2)
26 jul | 2018 Inhibitors of lysosomal function or serum starvation in control or LAMP2 deficient cells do not modify the cellular levels of Parkinson disease-associated DJ-1/PARK 7 protein. Sánchez-Lanzas, R , Castaño, JG . PLoS ONE - 13 (7) : e0201152 (PMID: 30048497) (doi:10.1371/journal.pone.0201152)
8 dic | 2017 Lysine-Less Variants of Spinal Muscular Atrophy SMN and SMNΔ7 Proteins Are Degraded by the Proteasome Pathway. Sánchez-Lanzas, R , Castaño, JG . Int J Mol Sci - 18 (12) (PMID: 29292768) (doi:10.3390/ijms18122667)
19 oct | 2017 CCAAT/Enhancer binding protein β silencing mitigates glial activation and neurodegeneration in a rat model of Parkinson's disease. Morales-Garcia, JA , Gine, E, Hernandez-Encinas, E, Aguilar-Morante, D , Sierra-Magro, A , Sanz-SanCristobal, M , Alonso-Gil, S , Sanchez-Lanzas, R, Castaño, JG , Santos, A , Perez-Castillo, A . Sci Rep - 7 (1) : 13526 (PMID: 29051532) (doi:10.1038/s41598-017-13269-4)
1 ago | 2016 Protein degradation in a LAMP-2-deficient B-lymphoblastoid cell line from a patient with Danon disease. Sánchez-Lanzas, R , Alvarez-Castelao, B , Bermejo, T , Ayuso, T, Tuñón, T, Castaño, JG . Biochim. Biophys. Acta - 1862 (8) : 1423-1432 (PMID: 27130438) (doi:10.1016/j.bbadis.2016.04.014)
19 dic | 2014 Proteins directly interacting with mammalian 20S proteasomal subunits and ubiquitin-independent proteasomal degradation. Sánchez-Lanzas, R , Castaño, JG . Biomolecules - 4 (4) : 1140-1154 (PMID: 25534281) (doi:10.3390/biom4041140)
15 jul | 2014 Epitope Mapping of Antibodies to Alpha-Synuclein in LRRK2 Mutation Carriers, Idiopathic Parkinson Disease Patients, and Healthy Controls. Alvarez-Castelao, B , Gorostidi, A, Ruíz-Martínez, J, López de Munain, A, Castaño, JG . Front Aging Neurosci - 6 : 169 (PMID: 25076905) (doi:10.3389/fnagi.2014.00169)
1 feb | 2014 Mechanism of cleavage of alpha-synuclein by the 20S proteasome and modulation of its degradation by the RedOx state of the N-terminal methionines. Alvarez-Castelao, B , Goethals, M, Vandekerckhove, J, Castaño, JG . Biochim. Biophys. Acta - 1843 (2) : 352-365 (PMID: 24315858) (doi:10.1016/j.bbamcr.2013.11.018)
7 feb | 2013 The N-terminal region of Nurr1 (a.a 1-31) is essential for its efficient degradation by the ubiquitin proteasome pathway. Alvarez-Castelao, B , Losada, F, Ahicart, P, Castaño, JG . PLoS ONE - 8 (2) : e55999 (PMID: 23409108) (doi:10.1371/journal.pone.0055999)
21 oct | 2012 A critical appraisal of quantitative studies of protein degradation in the framework of cellular proteostasis. Alvarez-Castelao, B , Ruiz-Rivas, C, Castaño, JG . Biochem Res Int - 2012 : 823597 (PMID: 23119163) (doi:10.1155/2012/823597)
6 feb | 2012 Reduced protein stability of human DJ-1/PARK7 L166P, linked to autosomal recessive Parkinson disease, is due to direct endoproteolytic cleavage by the proteasome. Alvarez-Castelao, B , Muñoz, C , Sánchez, I , Goethals, M, Vandekerckhove, J, Castaño, JG . Biochim. Biophys. Acta - 1823 (2) : 524-533 (PMID: 22173095) (doi:10.1016/j.bbamcr.2011.11.010)
1 ago | 2011 Synphilin-1 inhibits alpha-synuclein degradation by the proteasome. Alvarez-Castelao, B , Castaño, JG . Cell. Mol. Life Sci. - 68 (15) : 2643-2654 (PMID: 21103907) (doi:10.1007/s00018-010-0592-3)
9 oct | 2009 Cytomegalovirus promoter up-regulation is the major cause of increased protein levels of unstable reporter proteins after treatment of living cells with proteasome inhibitors. Alvarez-Castelao, B , Martín-Guerrero, I, García-Orad, A, Castaño, JG . J. Biol. Chem. - 284 (41) : 28253-28262 (PMID: 19679666) (doi:10.1074/jbc.M109.004101)
21 sep | 2009 Parkin deficiency increases the resistance of midbrain neurons and glia to mild proteasome inhibition: the role of autophagy and glutathione homeostasis. Casarejos, MJ, Solano, RM, Rodriguez-Navarro, JA, Gómez, A, Perucho, J, Castaño, JG , García de Yébenes, J, Mena, MA. J. Neurochem. - 110 (5) : 1523-1537 (PMID: 19549073) (doi:10.1111/j.1471-4159.2009.06248.x)
1 sep | 2007 Infection with Salmonella typhimurium has no effect on the composition and cleavage specificity of the 20S proteasome in human lymphoid cells. Marcilla, M, de Castro, JA, Castaño, JG , Alvarez, I. Immunology - 122 (1) : 131-139 (PMID: 17490436) (doi:10.1111/j.1365-2567.2007.02624.x)
25 mayo | 2007 Constitutive/hypoxic degradation of HIF-alpha proteins by the proteasome is independent of von Hippel Lindau protein ubiquitylation and the transactivation activity of the protein. Kong, X, Alvarez-Castelao, B , Lin, Z, Castaño, JG , Caro, J. J. Biol. Chem. - 282 (21) : 15498-15505 (PMID: 17403672) (doi:10.1074/jbc.M700704200)
1 sep | 2006 Inhibition of 26S proteasome activity by huntingtin filaments but not inclusion bodies isolated from mouse and human brain. Díaz-Hernández, M, Valera, AG, Morán, MA, Gómez-Ramos, P, Alvarez-Castelao, B , Castaño, JG , Hernández, F, Lucas, JJ. J. Neurochem. - 98 (5) : 1585-1596 (PMID: 16787406) (doi:10.1111/j.1471-4159.2006.03968.x)
2 sep | 2005 Generation of DNA double-strand breaks by two independent enzymatic activities in nuclear extracts. Blanco, MG, Boán, F, Barros, P, Castaño, JG , Gómez-Márquez, J. J. Mol. Biol. - 351 (5) : 995-991006 (PMID: 16051267) (doi:10.1016/j.jmb.2005.06.065)
29 ago | 2005 Mechanism of direct degradation of IkappaBalpha by 20S proteasome. Alvarez-Castelao, B , Castaño, JG . FEBS Lett. - 579 (21) : 4797-4802 (PMID: 16098527) (doi:10.1016/j.febslet.2005.07.060)
17 dic | 2004 alpha-Synuclein expression levels do not significantly affect proteasome function and expression in mice and stably transfected PC12 cell lines. Martìn-Clemente, B, Alvarez-Castelao, B , Mayo, I , Sierra, AB , Dìaz, V, Milán, M, Fariñas, I, Gómez-Isla, T, Ferrer, I, Castaño, JG . J. Biol. Chem. - 279 (51) : 52984-52990 (PMID: 15466467) (doi:10.1074/jbc.M409028200)
1 mayo | 2004 Proteasomal expression, induction of immunoproteasome subunits, and local MHC class I presentation in myofibrillar myopathy and inclusion body myositis. Ferrer, I, Martín, B, Castaño, JG , Lucas, JJ, Moreno, D, Olivé, M. J. Neuropathol. Exp. Neurol. - 63 (5) : 484-498 (PMID: 15198127)
1 oct | 2003 The COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activity. Gándara, ML , López, P , Hernando, R, Castaño, JG , Alemany, S . Mol. Cell. Biol. - 23 (20) : 7377-7390 (PMID: 14517305)
31 dic | 2002 The proteasome is a major autoantigen in multiple sclerosis. Mayo, I , Arribas, J, Villoslada, P, Alvarez DoForno, R, Rodríguez-Vilariño, S, Montalban, X, De Sagarra, MR, Castaño, JG . Brain - 125 (Pt 12) : 2658-2667 (PMID: 12429593)
15 ago | 2002 Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome. Lafarga, M, Berciano, MT, Pena, E, Mayo, I , Castaño, JG , Bohmann, D, Rodrigues, JP, Tavanez, JP, Carmo-Fonseca, M. Mol. Biol. Cell - 13 (8) : 2771-2782 (PMID: 12181345) (doi:10.1091/mbc.E02-03-0122)
1 jun | 2002 Proteasome dynamics during cell cycle in rat Schwann cells. Lafarga, M, Fernández, R, Mayo, I , Berciano, MT, Castaño, JG . Glia - 38 (4) : 313-328 (PMID: 12007144) (doi:10.1002/glia.10075)
1 oct | 2000 Antibodies against the COOH-terminal region of E. coli ClpP protease in patients with primary biliary cirrhosis. Mayo, I , Arizti, P, Parés, A, Oliva, J, Doforno, RA, de Sagarra, MR, Rodés, J, Castaño, JG . J. Hepatol. - 33 (4) : 528-536 (PMID: 11059856)
3 mar | 2000 Proteolytic processing and assembly of the C5 subunit into the proteasome complex. Rodriguez-Vilariño, S, Arribas, J, Arizti, P, Castaño, JG . J. Biol. Chem. - 275 (9) : 6592-6599 (PMID: 10692467)
25 dic | 1998 Degradation of the G protein-coupled receptor kinase 2 by the proteasome pathway. Penela, P, Ruiz-Gómez, A, Castaño, JG , Mayor, F. J. Biol. Chem. - 273 (52) : 35238-35244 (PMID: 9857063)
15 oct | 1996 Immunohistochemical distribution and electron microscopic subcellular localization of the proteasome in the rat CNS. Mengual, E, Arizti, P, Rodrigo, J, Giménez-Amaya, JM, Castaño, JG . J. Neurosci. - 16 (20) : 6331-6341 (PMID: 8815912)
26 mar | 1996 Phosphorylation of C8 and C9 subunits of the multicatalytic proteinase by casein kinase II and identification of the C8 phosphorylation sites by direct mutagenesis. Castaño, JG , Mahillo, E, Arizti, P, Arribas, J. Biochemistry - 35 (12) : 3782-3789 (PMID: 8619999) (doi:10.1021/bi952540s)
29 abr | 1994 Antibodies against the C2 COOH-terminal region discriminate the active and latent forms of the multicatalytic proteinase complex. Arribas, J, Arizti, P, Castaño, JG . J. Biol. Chem. - 269 (17) : 12858-12864 (PMID: 8175701)
5 oct | 1993 A comparative study of the chymotrypsin-like activity of the rat liver multicatalytic proteinase and the ClpP from Escherichia coli. Arribas, J, Castaño, JG . J. Biol. Chem. - 268 (28) : 21165-21171 (PMID: 8407953)
1 ago | 1991 Insulin-like effects of inositol phosphate-glycan on messenger RNA expression in rat hepatocytes. Alvarez, L , Avila, MA, Mato, JM , Castaño, JG , Varela-Nieto, I . Mol. Endocrinol. - 5 (8) : 1062-1068 (PMID: 1719385) (doi:10.1210/mend-5-8-1062)
10 oct | 1980 Activation of phospholipid methyltransferase by glucagon in rat hepatocytes. Castaño, JG , Alemany, S , Nieto, A, Mato, JM . J Biol Chem - 255 (19) : 9041-9043 (PMID: 6251072)