23 abr | 2025 RvD1 and LXA4 inhibitory effects on cardiac voltage-gated potassium channels. Cruz, A , Ronchi, C, Bartolucci, C, Socuéllamos, PG , Benito-Bueno, A , Severi, S, Zaza, A, Valenzuela, C . Biomed Pharmacother - 187 : 118083 (PMID: 40273690) (doi:10.1016/j.biopha.2025.118083)
11 dic | 2024 Kir2.1 mutations differentially increase the risk of flecainide proarrhythmia in Andersen Tawil Syndrome. Cruz, FM, Moreno-Manuel, AI, Pérez, PS, Ruiz-Robles, JM, Socuellamos, PG, Gutiérrez, LK, Vera-Pedrosa, ML, Gutierrez, AT, Mondéjar Parreño, G, Macías, Á , Martínez-Carrascoso, I, Bermúdez-Jiménez, FJ, Arias Santiago, S, Martínez de Benito, F, Braza-Boils, A, Valenzuela, C , Morillo, CA, Zorio, E, Jiménez-Jaimez, J, Jalife, J. medRxiv (PMID: 39711719) (doi:10.1101/2024.12.10.24318629)
28 oct | 2024 Molecular mapping of KCNE4-dependent regulation of Kv1.3. Sastre, D, Colomer-Molera, M, Roig, SR, de Benito-Bueno, A , Socuellamos, PG , Fernandez-Ballester, G, Valenzuela, C , Felipe, A . Am J Physiol Cell Physiol (PMID: 39466181) (doi:10.1152/ajpcell.00499.2024)
14 jun | 2024 KCNE4-dependent modulation of Kv1.3 pharmacology. Sastre, D, Colomer-Molera, M, de Benito-Bueno, A , Valenzuela, C , Fernández-Ballester, G, Felipe, A . Biochem Pharmacol (PMID: 38880360) (doi:10.1016/j.bcp.2024.116368)
29 ene | 2024 Routing of Kv7.1 to endoplasmic reticulum plasma membrane junctions. Serrano-Novillo, C, Estadella, I, Navarro-Pérez, M, Oliveras, A, de Benito-Bueno, A , Socuéllamos, PG , Bosch, M, Coronado, MJ, Sastre, D, Valenzuela, C , Soeller, C, Felipe, A . Acta Physiol (Oxf) (PMID: 38282556) (doi:10.1111/apha.14106)
18 mar | 2023 Trabectedin modulates macrophage polarization in the tumor-microenvironment. Role of KV1.3 and KV1.5 channels. Peraza, DA , Povo-Retana, A , Mojena, M , García-Redondo, AB, Avilés, P, Boscá, L , Valenzuela, C . Biomed Pharmacother - 161 : 114548 (PMID: 36940615) (doi:10.1016/j.biopha.2023.114548)
10 feb | 2023 IQM-22110, a new selective inhibitor of KChIP3 and its electrophysiological effects on Kv4.3, Kv4.3/KChIP3 and Kv4.3/KChIP2 currents. Socuéllamos, PG , de Benito-Bueno, A , Ropero, M , Diez, S , Elizalde, P, Bonache, MA, Viedma, C, Martín-Martínez, M, Gutiérrez-Rodríguez, M, Valenzuela, C . Biophys J - 122 (3S1) : 255a (PMID: 36783256) (doi:10.1016/j.bpj.2022.11.1474)
3 feb | 2023 Sigma-1 receptor modulation fine-tunes KV1.5 channels and impacts pulmonary vascular function. Vera-Zambrano, A , Baena-Nuevo, M , Rinné, S, Villegas-Esguevillas, M, Barreira, B, Telli, G, de Benito-Bueno, A , Blázquez, JA, Climent, B, Pérez-Vizcaino, F, Valenzuela, C , Decher, N, Gonzalez, T , Cogolludo, A. Pharmacol Res (PMID: 36740150) (doi:10.1016/j.phrs.2023.106684)
1 feb | 2023 Beneficial effect of TLR4 blockade by a specific aptamer antagonist after acute myocardial infarction. Paz-García, M , Povo-Retana, A , Jaén, RI , Prieto, P , Peraza, DA , Zaragoza, C, Hernandez-Jimenez, M, Pineiro, D, Regadera, J, García-Bermejo, ML, Rodríguez-Serrano, EM, Sánchez-García, S , Moro, MA, Lizasoaín, I, Delgado, C , Valenzuela, C , Boscá, L . Biomed Pharmacother - 158 : 114214 (PMID: 36916435) (doi:10.1016/j.biopha.2023.114214)
7 nov | 2022 Resolvin D2 Attenuates Cardiovascular Damage in Angiotensin Ii-Induced Hypertension. Díaz Del Campo, LS, García-Redondo, AB, Rodriguez, C, Zaragoza, C, Duro-Sánchez, S, Palmas, F, de Benito-Bueno, A , Socuéllamos, PG , Peraza, DA , Rodrigues-Diez, R, Valenzuela, C , Dalli, J, Salaices, M, Briones, AM. Hypertension (PMID: 36337053) (doi:10.1161/HYPERTENSIONAHA.122.19448)
6 sep | 2022 A novel loss-of-function mutation of the voltage-gated potassium channel Kv10.2 involved in epilepsy and autism. Galán-Vidal, J, Socuéllamos, PG , Baena-Nuevo, M , Contreras, L, González, T , Pérez-Poyato, MS, Valenzuela, C , González-Lamuño, D, Gandarillas, A. Orphanet J Rare Dis - 17 (1) : 345 (PMID: 36068614) (doi:10.1186/s13023-022-02499-z)
15 ago | 2022 Modulation of KV4.3-KChIP2 Channels by IQM-266: Role of DPP6 and KCNE2. de Benito-Bueno, A , Socuellamos, PG , Merinero, YG , Cercos, P, Izquierdo, C, Daniel-Mozo, M, Marín-Olivero, I, Perez-Lara, A, Gonzalez-Vera, JA, Orte, A, Albert, A, Martin-Martinez, M, Gutierrez-Rodriguez, M, Valenzuela, C . Int J Mol Sci - 23 (16) (PMID: 36012438) (doi:10.3390/ijms23169170)
15 feb | 2022 IQM-PC332, a Novel DREAM Ligand with Antinociceptive Effect on Peripheral Nerve Injury-Induced Pain. Socuéllamos, PG , Olivos-Oré, LA, Barahona, MV, Cercós, P, Pérez Pascual, M, Arribas-Blázquez, M , Naranjo, JR, Valenzuela, C , Gutiérrez-Rodríguez, M, Artalejo, AR. Int J Mol Sci - 23 (4) (PMID: 35216258) (doi:10.3390/ijms23042142)
29 sep | 2021 Graphene Particles Interfere with Pro-Inflammatory Polarization of Human Macrophages: Functional and Electrophysiological Evidence. Povo-Retana, A , Mojena, M , Boscá, A, Pedrós, J, Peraza, DA , Valenzuela, C , Laparra, JM, Calle, F, Boscá, L . Adv Biol (Weinh) (PMID: 34590442) (doi:10.1002/adbi.202100882)
4 abr | 2021 Identification of a critical binding site for local anesthetics in the side pockets of Kv1 channels. Kiper, AK, Bedoya, M, Stalke, S, Marzian, S , Ramírez, D, de la Cruz, A , Peraza, DA , Vera-Zambrano, A , Márquez Montesinos, JCE, Arévalo Ramos, BA, Rinné, S, Gonzalez, T , Valenzuela, C , Gonzalez, W, Decher, N. Br J Pharmacol (PMID: 33817777) (doi:10.1111/bph.15480)
8 feb | 2021 KV 1.3 channels are novel determinants of macrophage-dependent endothelial dysfunction in a mouse model with angiotensin II-induced hypertension. Olivencia, MA, Martínez-Casales, M, Peraza, DA , García-Redondo, AB, Mondéjar-Parreño, G, Hernanz, R, Salaices, M, Cogolludo, A, Pennington, MW, Valenzuela, C , Briones, AM. Br J Pharmacol (PMID: 33556997) (doi:10.1111/bph.15407)
31 ene | 2021 Pharmacological Approaches for the Modulation of the Potassium Channel KV4.x and KChIPs. Cercós, P, Peraza, DA , Benito-Bueno, A , Socuéllamos, PG , Aziz-Nignan, A, Arrechaga-Estévez, D, Beato, E, Peña-Acevedo, E, Albert, A, González-Vera, JA, Rodríguez, Y, Martín-Martínez, M, Valenzuela, C , Gutiérrez-Rodríguez, M. Int J Mol Sci - 22 (3) (PMID: 33572566) (doi:10.3390/ijms22031419)
29 ene | 2021 KV1.5-KVβ1.3 Recycling Is PKC-Dependent. Macias, A , de la Cruz, A , Peraza, DA , Benito-Bueno, A , Gonzalez, T , Valenzuela, C . Int J Mol Sci - 22 (3) (PMID: 33572906) (doi:10.3390/ijms22031336)
1 abr | 2020 The unconventional biogenesis of Kv7.1-KCNE1 complexes. Oliveras, A, Serrano-Novillo, C, Moreno, C , de la Cruz, A , Valenzuela, C , Soeller, C, Comes, N, Felipe, A . Sci Adv - 6 (14) : eaay4472 (PMID: 32270035) (doi:10.1126/sciadv.aay4472)
13 mayo | 2019 Targeting the neuronal calcium sensor DREAM with small-molecules for Huntington's disease treatment. Lopez-Hurtado, A, Peraza, DA , Cercos, P, Lagartera, L, Gonzalez, P, Dopazo, XM, Herranz, R, Gonzalez, T , Martin-Martinez, M, Mellström, B, Naranjo, JR, Valenzuela, C , Gutierrez-Rodriguez, M. Sci Rep - 9 (1) : 7260 (PMID: 31086218) (doi:10.1038/s41598-019-43677-7)
18 mar | 2019 "Activation of Kv7 channels as a novel mechanism for NO/cGMP-induced pulmonary vasodilation". Mondéjar-Parreño, G, Moral-Sanz, J, Barreira, B, De la Cruz, A , Gonzalez, T , Callejo, M, Esquivel-Ruiz, S, Morales-Cano, D, Moreno, L, Valenzuela, C , Perez-Vizcaino, F, Cogolludo, A. Br. J. Pharmacol. (PMID: 30883701) (doi:10.1111/bph.14662)
4 feb | 2019 Identification of IQM-266, a Novel DREAM Ligand That Modulates KV4 Currents. Peraza, DA , Cercós, P, Miaja, P , Merinero, YG , Lagartera, L, Socuéllamos, PG , Izquierdo García, C, Sánchez, SA , López-Hurtado, A, Martín-Martínez, M, Olivos-Oré, LA, Naranjo, JR, Artalejo, AR, Gutiérrez-Rodríguez, M, Valenzuela, C . Front Mol Neurosci - 12 : 11 (PMID: 30787866) (doi:10.3389/fnmol.2019.00011)
22 ene | 2019 Corrigendum to Supplemental Material: 'D242N, a KV7.1 LQTS mutation uncovers a key residue for IKs voltage dependence' [Journal of Molecular and Cellular Cardiology, Volume 110, September 2017, Pages 61-69]. Moreno, C , Oliveras, A, Bartolucci, C, Muñoz, C, de la Cruz, A , Peraza, DA , Gimeno, JR, Martín-Martínez, M, Severi, S, Felipe, A , Lambiase, PD, González, T , Valenzuela, C . J. Mol. Cell. Cardiol. - 128 : 25 (PMID: 30682566) (doi:10.1016/j.yjmcc.2019.01.014)
1 ene | 2019 Differential effect of Androctonus australis hector venom components on macrophage KV channels: electrophysiological characterization. Khemili, D, Valenzuela, C , Laraba-Djebari, F, Hammoudi-Triki, D. Eur. Biophys. J. - 48 (1) : 1-13 (PMID: 30006779) (doi:10.1007/s00249-018-1323-1)
1 sep | 2017 D242N, a KV7.1 LQTS mutation uncovers a key residue for IKs voltage dependence. Moreno, C , Oliveras, A, Bartolucci, C, Muñoz, C, de la Cruz, A , Peraza, DA , Gimeno, JR, Martín-Martínez, M, Severi, S, Felipe, A , Lambiase, PD, Gonzalez, T , Valenzuela, C . J. Mol. Cell. Cardiol. - 110 : 61-69 (PMID: 28739325) (doi:10.1016/j.yjmcc.2017.07.009)
31 mar | 2017 Fludarabine Inhibits KV1.3 Currents in Human B Lymphocytes. de la Cruz, A , Vera-Zambrano, A , Peraza, DA , Valenzuela, C , Zapata, JM , Perez-Chacon, G , Gonzalez, T . Front Pharmacol - 8 : 177 (PMID: 28408885) (doi:10.3389/fphar.2017.00177)
24 nov | 2016 In-Depth Study of the Interaction, Sensitivity, and Gating Modulation by PUFAs on K(+) Channels; Interaction and New Targets. Moreno, C , de la Cruz, A , Valenzuela, C . Front Physiol - 7 : 578 (PMID: 27933000) (doi:10.3389/fphys.2016.00578)
1 sep | 2016 M-channels and n-3 polyunsaturated fatty acids: role in pain and epilepsy. Valenzuela, C . Acta Physiol (Oxf) - 218 (1) : 7-9 (PMID: 27287186) (doi:10.1111/apha.12734)
11 ene | 2016 Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease. Naranjo, JR, Zhang, H, Villar, D , González, P, Dopazo, XM, Morón-Oset, J, Higueras, E, Oliveros, JC, Arrabal, MD, Prieto, A , Cercós, P, González, T , De la Cruz, A , Casado-Vela, J , Rábano, A, Valenzuela, C , Gutierrez-Rodriguez, M, Li, JY, Mellström, B. J. Clin. Invest. (PMID: 26752648) (doi:10.1172/JCI82670)
16 oct | 2015 Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death. Molina-Guijarro, JM, García, C, Macías, Á , García-Fernández, LF, Moreno, C , Reyes, F, Martínez-Leal, JF, Fernández, R, Martínez, V, Valenzuela, C , Lillo, MP, Galmarini, CM. PLoS ONE - 10 (10) : e0140782 (PMID: 26474061) (doi:10.1371/journal.pone.0140782)
1 sep | 2015 A new KCNQ1 mutation at the S5 segment that impairs its association with KCNE1 is responsible for short QT syndrome. Moreno, C , Oliveras, A, de la Cruz, A , Bartolucci, C, Muñoz, C, Salar, E, Gimeno, JR, Severi, S, Comes, N, Felipe, A , González, T , Lambiase, P, Valenzuela, C . Cardiovasc. Res. - 107 (4) : 613-623 (PMID: 26168993) (doi:10.1093/cvr/cvv196)
1 feb | 2015 Marine n-3 PUFAs modulate IKs gating, channel expression, and location in membrane microdomains. Moreno, C , de la Cruz, A , Oliveras, A, Kharche, SR, Guizy, M, Comes, N, Starý, T, Ronchi, C, Rocchetti, M, Baró, I, Loussouarn, G, Zaza, A, Severi, S, Felipe, A , Valenzuela, C . Cardiovasc. Res. - 105 (2) : 223-232 (PMID: 25497550) (doi:10.1093/cvr/cvu250)
1 nov | 2014 PKC inhibition results in a Kv 1.5 + Kv β1.3 pharmacology closer to Kv 1.5 channels. Macías, A , de la Cruz, A , Prieto, A , Peraza, DA , Tamkun, MM, González, T , Valenzuela, C . Br. J. Pharmacol. - 171 (21) : 4914-4926 (PMID: 24946104) (doi:10.1111/bph.12822)
1 jul | 2014 Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology. Oliveras, A, Roura-Ferrer, M, Solé, L, de la Cruz, A , Prieto, A , Etxebarria, A, Manils, J, Morales-Cano, D, Condom, E, Soler, C, Cogolludo, A, Valenzuela, C , Villarroel, A, Comes, N, Felipe, A . Arterioscler. Thromb. Vasc. Biol. - 34 (7) : 1522-1530 (PMID: 24855057) (doi:10.1161/ATVBAHA.114.303801)
15 dic | 2013 Modulation of voltage-dependent and inward rectifier potassium channels by 15-epi-lipoxin-A4 in activated murine macrophages: implications in innate immunity. Moreno, C , Prieto, P , Macías, Á , Pimentel-Santillana, M , de la Cruz, A , Través, PG , Boscá, L , Valenzuela, C . J. Immunol. - 191 (12) : 6136-6146 (PMID: 24249731) (doi:10.4049/jimmunol.1300235)
1 nov | 2012 Stereoselective interactions between local anesthetics and ion channels. Valenzuela, C , Moreno, C , de la Cruz, A , Macías, Á , Prieto, Á , González, T . Chirality - 24 (11) : 944-950 (PMID: 22674834) (doi:10.1002/chir.22051)
10 sep | 2012 Polyunsaturated Fatty acids modify the gating of kv channels. Moreno, C , Macias, A , Prieto, A , De La Cruz, A , Valenzuela, C . Front Pharmacol - 3 : 163 (PMID: 22973228) (doi:10.3389/fphar.2012.00163)
1 ago | 2012 Female gender: risk factor for congenital long QT-related arrhythmias. Valenzuela, C . Cardiovasc. Res. - 95 (3) : 263-264 (PMID: 22721991) (doi:10.1093/cvr/cvs203)
9 jul | 2012 Effects of n-3 Polyunsaturated Fatty Acids on Cardiac Ion Channels. Moreno, C , Macías, A , Prieto, A , de la Cruz, A , González, T , Valenzuela, C . Front Physiol - 3 : 245 (PMID: 22934003) (doi:10.3389/fphys.2012.00245)
15 jun | 2012 Protein kinase C (PKC) activity regulates functional effects of Kvβ1.3 subunit on KV1.5 channels: identification of a cardiac Kv1.5 channelosome. David, M , Macías, Á , Moreno, C , Prieto, Á , Martínez-Mármol, R, Vicente, R, González, T , Felipe, A , Tamkun, MM, Valenzuela, C . J. Biol. Chem. - 287 (25) : 21416-21428 (PMID: 22547057) (doi:10.1074/jbc.M111.328278)
1 jul | 2011 Ceramide inhibits Kv currents and contributes to TP-receptor-induced vasoconstriction in rat and human pulmonary arteries. Moral-Sanz, J, Gonzalez, T , Menendez, C, David, M , Moreno, L, Macias, A , Cortijo, J, Valenzuela, C , Perez-Vizcaino, F, Cogolludo, A. Am. J. Physiol., Cell Physiol. - 301 (1) : C186-94 (PMID: 21490312) (doi:10.1152/ajpcell.00243.2010)
27 abr | 2011 Irvalec inserts into the plasma membrane causing rapid loss of integrity and necrotic cell death in tumor cells. Molina-Guijarro, JM, Macías, Á , García, C, Muñoz, E, García-Fernández, LF , David, M , Núñez, L, Martínez-Leal, JF, Moneo, V, Cuevas, C, Lillo, MP, Villalobos Jorge, C, Valenzuela, C , Galmarini, CM. PLoS ONE - 6 (4) : e19042 (PMID: 21556352) (doi:10.1371/journal.pone.0019042)
1 dic | 2010 Celecoxib blocks cardiac Kv1.5, Kv4.3 and Kv7.1 (KCNQ1) channels: effects on cardiac action potentials. Macías, A , Moreno, C , Moral-Sanz, J, Cogolludo, A, David, M , Alemanni, M, Pérez-Vizcaíno, F, Zaza, A, Valenzuela, C , González, T . J. Mol. Cell. Cardiol. - 49 (6) : 984-992 (PMID: 20858500) (doi:10.1016/j.yjmcc.2010.09.012)
15 sep | 2010 Immunomodulatory effects of diclofenac in leukocytes through the targeting of Kv1.3 voltage-dependent potassium channels. Villalonga, N, David, M , Bielańska, J, González, T , Parra, D, Soler, C, Comes, N, Valenzuela, C , Felipe, A . Biochem. Pharmacol. - 80 (6) : 858-866 (PMID: 20488163) (doi:10.1016/j.bcp.2010.05.012)
1 jun | 2010 Kv1.5-Kv beta interactions: molecular determinants and pharmacological consequences. González, T , David, M , Moreno, C , Macías, A , Valenzuela, C . Mini Rev Med Chem - 10 (7) : 635-642 (PMID: 20500153)
1 feb | 2010 Immunomodulation of voltage-dependent K+ channels in macrophages: molecular and biophysical consequences. Villalonga, N, David, M , Bielanska, J, Vicente, R, Comes, N, Valenzuela, C , Felipe, A . J. Gen. Physiol. - 135 (2) : 135-147 (PMID: 20100893) (doi:10.1085/jgp.200910334)
8 oct | 2008 Ultrafast sodium channel block by dietary fish oil prevents dofetilide-induced ventricular arrhythmias in rabbit hearts. Dujardin, KS, Dumotier, B, David, M , Guizy, M, Valenzuela, C , Hondeghem, LM. Am. J. Physiol. Heart Circ. Physiol. - 295 (4) : H1414-21 (PMID: 18676685) (doi:10.1152/ajpheart.01219.2007)
1 mayo | 2008 Cell cycle-dependent expression of Kv1.5 is involved in myoblast proliferation. Villalonga, N, Martínez-Mármol, R, Roura-Ferrer, M, David, M , Valenzuela, C , Soler, C, Felipe, A . Biochim. Biophys. Acta - 1783 (5) : 728-736 (PMID: 18230363) (doi:10.1016/j.bbamcr.2008.01.001)
11 abr | 2008 Differential regulation of Na(v)beta subunits during myogenesis. David, M , Martínez-Mármol, R, Gonzalez, T , Felipe, A , Valenzuela, C . Biochem. Biophys. Res. Commun. - 368 (3) : 761-766 (PMID: 18261980) (doi:10.1016/j.bbrc.2008.01.138)
18 feb | 2008 Modulation of the atrial specific Kv1.5 channel by the n-3 polyunsaturated fatty acid, alpha-linolenic acid. Guizy, M, David, M , Arias, C, Zhang, L, Cofán, M, Ruiz-Gutiérrez, V, Ros, E, Lillo, MP, Martens, JR, Valenzuela, C . J. Mol. Cell. Cardiol. - 44 (2) : 323-335 (PMID: 18155022) (doi:10.1016/j.yjmcc.2007.11.004)
1 dic | 2007 Voltage-dependent Na+ channel phenotype changes in myoblasts. Consequences for cardiac repair. Martínez-Mármol, R, David, M , Sanches, R, Roura-Ferrer, M, Villalonga, N, Sorianello, E, Webb, SM, Zorzano, A, Gumà, A, Valenzuela, C , Felipe, A . Cardiovasc. Res. - 76 (3) : 430-441 (PMID: 17900547) (doi:10.1016/j.cardiores.2007.08.009)
29 oct | 2007 Kvbeta1.3 reduces the degree of stereoselective bupivacaine block of Kv1.5 channels. Arias, C, Guizy, M, David, M , Marzian, S , González, T , Decher, N, Valenzuela, C . Anesthesiology - 107 (4) : 641-651 (PMID: 17893461) (doi:10.1097/01.anes.0000282100.32923.5c)
1 ene | 2006 The induction of NOS2 expression by the hybrid cecropin A-melittin antibiotic peptide CA(1-8)M(1-18) in the monocytic line RAW 264.7 is triggered by a temporary and reversible plasma membrane permeation. Arias, C, Guizy, M, Luque-Ortega, JR, Guerrero, E, de la Torre, BG, Andreu, D, Rivas, L, Valenzuela, C . Biochim. Biophys. Acta - 1763 (1) : 110-119 (PMID: 16377003) (doi:10.1016/j.bbamcr.2005.11.003)
7 nov | 2005 {Omega}-3 and {omega}-6 polyunsaturated fatty acids block HERG channels. Guizy, M, Arias, C, David, M , González, T , Valenzuela, C . Am. J. Physiol., Cell Physiol. - 289 (5) : C1251-60 (PMID: 15987770) (doi:10.1152/ajpcell.00036.2005)
1 abr | 2004 Interaction of angiotensin II with the angiotensin type 2 receptor inhibits the cardiac transient outward potassium current. Caballero, R, Gómez, R, Moreno, I, Nuñez, L, González, T , Arias, C, Guizy, M, Valenzuela, C , Tamargo, J, Delpón, E. Cardiovasc. Res. - 62 (1) : 86-95 (PMID: 15023555) (doi:10.1016/j.cardiores.2003.12.029)
1 abr | 2004 Pharmacology of cardiac potassium channels. Tamargo, J, Caballero, R, Gómez, R, Valenzuela, C , Delpón, E. Cardiovasc. Res. - 62 (1) : 9-33 (PMID: 15023549) (doi:10.1016/j.cardiores.2003.12.026)
1 jun | 2003 Pharmacological electrical remodelling in human atria induced by chronic beta-blockade. Valenzuela, C . Cardiovasc. Res. - 58 (3) : 498-500 (PMID: 12798421)
5 mar | 2003 Effects of propafenone and its main metabolite, 5-hydroxypropafenone, on HERG channels. Arias, C, González, T , Moreno, I, Caballero, R, Delpón, E, Tamargo, J, Valenzuela, C . Cardiovasc. Res. - 57 (3) : 660-669 (PMID: 12618228)
18 feb | 2003 Spironolactone and its main metabolite, canrenoic acid, block human ether-a-go-go-related gene channels. Caballero, R, Moreno, I, González, T , Arias, C, Valenzuela, C , Delpón, E, Tamargo, J. Circulation - 107 (6) : 889-895 (PMID: 12591761)
1 feb | 2003 Effects of irbesartan on cloned potassium channels involved in human cardiac repolarization. Moreno, I, Caballero, R, González, T , Arias, C, Valenzuela, C , Iriepa, I, Gálvez, E, Tamargo, J, Delpón, E. J. Pharmacol. Exp. Ther. - 304 (2) : 862-873 (PMID: 12538844) (doi:10.1124/jpet.102.042325)
9 dic | 2002 Assembly with the Kvbeta1.3 subunit modulates drug block of hKv1.5 channels. González, T , Navarro-Polanco, R, Arias, C, Caballero, R, Moreno, I, Delpón, E, Tamargo, J, Tamkun, MM, Valenzuela, C . Mol. Pharmacol. - 62 (6) : 1456-1463 (PMID: 12435814)
5 dic | 2002 Effects of levobupivacaine, ropivacaine and bupivacaine on HERG channels: stereoselective bupivacaine block. González, T , Arias, C, Caballero, R, Moreno, I, Delpón, E, Tamargo, J, Valenzuela, C . Br. J. Pharmacol. - 137 (8) : 1269-1279 (PMID: 12466236) (doi:10.1038/sj.bjp.0704978)
1 oct | 2002 Putative binding sites for benzocaine on a human cardiac cloned channel (Kv1.5). Caballero, R, Moreno, I, González, T , Valenzuela, C , Tamargo, J, Delpón, E. Cardiovasc. Res. - 56 (1) : 104-117 (PMID: 12237171)
20 sep | 2001 Bupivacaine effects on hKv1.5 channels are dependent on extracellular pH. Longobardo, M, González, T , Caballero, R, Delpón, E, Tamargo, J, Valenzuela, C . Br. J. Pharmacol. - 134 (2) : 359-369 (PMID: 11564654) (doi:10.1038/sj.bjp.0704251)
19 abr | 2001 Direct effects of candesartan and eprosartan on human cloned potassium channels involved in cardiac repolarization. Caballero, R, Delpón, E, Valenzuela, C , Longobardo, M, González, T , Tamargo, J. Mol. Pharmacol. - 59 (4) : 825-836 (PMID: 11259627)
22 feb | 2001 Effects of bupivacaine and a novel local anesthetic, IQB-9302, on human cardiac K+ channels. González, T , Longobardo, M, Caballero, R, Delpón, E, Tamargo, J, Valenzuela, C . J. Pharmacol. Exp. Ther. - 296 (2) : 573-583 (PMID: 11160646)
1 ene | 2001 Stereoselective effects of the enantiomers of a new local anaesthetic, IQB-9302, on a human cardiac potassium channel (Kv1.5). González, T , Longobardo, M, Caballero, R, Delpón, E, Sinisterra, JV, Tamargo, J, Valenzuela, C . Br. J. Pharmacol. - 132 (2) : 385-392 (PMID: 11159686) (doi:10.1038/sj.bjp.0703844)
1 mayo | 2000 Effects of a quaternary bupivacaine derivative on delayed rectifier K(+) currents. Longobardo, M, González, T , Navarro-Polanco, R, Caballero, R, Delpón, E, Tamargo, J, Snyders, DJ, Tamkun, MM, Valenzuela, C . Br. J. Pharmacol. - 130 (2) : 391-401 (PMID: 10807678) (doi:10.1038/sj.bjp.0703334)
14 mar | 2000 Losartan and its metabolite E3174 modify cardiac delayed rectifier K(+) currents. Caballero, R, Delpón, E, Valenzuela, C , Longobardo, M, Tamargo, J. Circulation - 101 (10) : 1199-1205 (PMID: 10715269)
1 dic | 1999 Blockade of cardiac potassium and other channels by antihistamines. Delpón, E, Valenzuela, C , Tamargo, J. Drug Saf - 21 Suppl 1 : 11-8; discussion 81-7 (PMID: 10597864)
1 nov | 1999 Effects of rupatadine, a new dual antagonist of histamine and platelet-activating factor receptors, on human cardiac kv1.5 channels. Caballero, R, Valenzuela, C , Longobardo, M, Tamargo, J, Delpón, E. Br. J. Pharmacol. - 128 (5) : 1071-1081 (PMID: 10556945) (doi:10.1038/sj.bjp.0702890)
1 mayo | 1999 Benzocaine enhances and inhibits the K+ current through a human cardiac cloned channel (Kv1.5). Delpón, E, Caballero, R, Valenzuela, C , Longobardo, M, Snyders, D, Tamargo, J. Cardiovasc. Res. - 42 (2) : 510-520 (PMID: 10533586)
1 ene | 1999 Functional expression of an inactivating potassium channel (Kv4.3) in a mammalian cell line. Franqueza, L, Valenzuela, C , Eck, J, Tamkun, MM, Tamargo, J, Snyders, DJ. Cardiovasc. Res. - 41 (1) : 212-219 (PMID: 10325968)
1 nov | 1998 Effects of propafenone and 5-hydroxy-propafenone on hKv1.5 channels. Franqueza, L, Valenzuela, C , Delpón, E, Longobardo, M, Caballero, R, Tamargo, J. Br. J. Pharmacol. - 125 (5) : 969-978 (PMID: 9846634) (doi:10.1038/sj.bjp.0702129)
1 jul | 1998 Structural determinants of potency and stereoselective block of hKv1.5 channels induced by local anesthetics. Longobardo, M, Delpón, E, Caballero, R, Tamargo, J, Valenzuela, C . Mol. Pharmacol. - 54 (1) : 162-169 (PMID: 9658202)
31 dic | 1997 Molecular determinants of stereoselective bupivacaine block of hKv1.5 channels. Franqueza, L, Longobardo, M, Vicente, J, Delpón, E, Tamkun, MM, Tamargo, J, Snyders, DJ, Valenzuela, C . Circ. Res. - 81 (6) : 1053-1064 (PMID: 9400387)
1 nov | 1997 Effect of descarboethoxyloratadine, the major metabolite of loratadine, on the human cardiac potassium channel Kv1.5. Caballero, R, Delpón, E, Valenzuela, C , Longobardo, M, Franqueza, L, Tamargo, J. Br. J. Pharmacol. - 122 (5) : 796-798 (PMID: 9384491) (doi:10.1038/sj.bjp.0701468)
1 ago | 1997 Block of human cardiac Kv1.5 channels by loratadine: voltage-, time- and use-dependent block at concentrations above therapeutic levels. Delpón, E, Valenzuela, C , Gay, P, Franqueza, L, Snyders, DJ, Tamargo, J. Cardiovasc. Res. - 35 (2) : 341-350 (PMID: 9349397)
20 mayo | 1997 Comparative effects of nonsedating histamine H1 receptor antagonists, ebastine and terfenadine, on human Kv1.5 channels. Valenzuela, C , Delpón, E, Franqueza, L, Gay, P, Vicente, J, Tamargo, J. Eur. J. Pharmacol. - 326 (2-3) : 257-263 (PMID: 9196279)
1 mar | 1997 Effects of ropivacaine on a potassium channel (hKv1.5) cloned from human ventricle. Valenzuela, C , Delpón, E, Franqueza, L, Gay, P, Snyders, DJ, Tamargo, J. Anesthesiology - 86 (3) : 718-728 (PMID: 9066339)
1 ene | 1997 Electrophysiological effects of CI-980, a tubulin binding agent, on guinea-pig papillary muscles. Pérez, O, Valenzuela, C , Delpón, E, Tamargo, J. Br. J. Pharmacol. - 120 (2) : 187-192 (PMID: 9117108) (doi:10.1038/sj.bjp.0700878)
1 ago | 1996 Class III antiarrhythmic effects of zatebradine. Time-, state-, use-, and voltage-dependent block of hKv1.5 channels. Valenzuela, C , Delpón, E, Franqueza, L, Gay, P, Pérez, O, Tamargo, J, Snyders, DJ. Circulation - 94 (3) : 562-570 (PMID: 8759103)
1 mar | 1996 Mechanisms of block of a human cloned potassium channel by the enantiomers of a new bradycardic agent: S-16257-2 and S-16260-2. Delpón, E, Valenzuela, C , Pérez, O, Franqueza, L, Gay, P, Snyders, DJ, Tamargo, J. Br. J. Pharmacol. - 117 (6) : 1293-1301 (PMID: 8882628)
15 nov | 1995 Stereoselective block of cardiac sodium channels by bupivacaine in guinea pig ventricular myocytes. Valenzuela, C , Snyders, DJ, Bennett, PB, Tamargo, J, Hondeghem, LM. Circulation - 92 (10) : 3014-3024 (PMID: 7586272)
21 sep | 1995 On the molecular nature of the lidocaine receptor of cardiac Na+ channels. Modification of block by alterations in the alpha-subunit III-IV interdomain. Bennett, PB, Valenzuela, C , Chen, LQ, Kallen, RG. Circ. Res. - 77 (3) : 584-592 (PMID: 7641328)
1 ago | 1995 Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers. Valenzuela, C , Delpón, E, Tamkun, MM, Tamargo, J, Snyders, DJ. Biophys. J. - 69 (2) : 418-427 (PMID: 8527655) (doi:10.1016/S0006-3495(95)79914-3)
1 jul | 1995 Effects of the two enantiomers, S-16257-2 and S-16260-2, of a new bradycardic agent on guinea-pig isolated cardiac preparations. Pérez, O, Gay, P, Franqueza, L, Carrón, R, Valenzuela, C , Delpón, E, Tamargo, J. Br. J. Pharmacol. - 115 (5) : 787-794 (PMID: 8548178)
1 jul | 1995 Electromechanical effects of zatebradine on isolated guinea pig cardiac preparations. Pérez, O, Gay, P, Franqueza, L, Carrón, R, Valenzuela, C , Delpón, E, Tamargo, J. J. Cardiovasc. Pharmacol. - 26 (1) : 46-54 (PMID: 7564364)
28 feb | 1995 Propafenone preferentially blocks the rapidly activating component of delayed rectifier K+ current in guinea pig ventricular myocytes. Voltage-independent and time-dependent block of the slowly activating component. Delpón, E, Valenzuela, C , Pérez, O, Casis, O, Tamargo, J. Circ. Res. - 76 (2) : 223-235 (PMID: 7834833)
1 sep | 1994 Effects of lisinopril on cardiac contractility and ionic currents. Valenzuela, C , Pérez, O, Delpón, E, Tamargo, J. Gen. Pharmacol. - 25 (5) : 825-832 (PMID: 7835625)
1 jul | 1994 Gating of cardiac Na+ channels in excised membrane patches after modification by alpha-chymotrypsin. Valenzuela, C , Bennett, PB. Biophys. J. - 67 (1) : 161-171 (PMID: 7918983) (doi:10.1016/S0006-3495(94)80465-5)
28 abr | 1994 Imipramine blocks rapidly activating and delays slowly activating K+ current activation in guinea pig ventricular myocytes. Valenzuela, C , Sánchez-Chapula, J, Delpón, E, Elizalde, A, Pérez, O, Tamargo, J. Circ. Res. - 74 (4) : 687-699 (PMID: 8137505)
1 mar | 1994 Class I and III antiarrhythmic actions of prazosin in guinea-pig papillary muscles. Pérez, O, Valenzuela, C , Delpón, E, Tamargo, J. Br. J. Pharmacol. - 111 (3) : 717-722 (PMID: 8019750)
1 nov | 1993 Treatment of left ventricular hypertrophy in hypertensive patients. Tamargo, J, Delpón, E, Valenzuela, C . Eur. Heart J. - 14 Suppl J : 102-106 (PMID: 8281952)
1 jul | 1993 Effects of lisinopril on electromechanical properties and membrane currents in guinea-pig cardiac preparations. Valenzuela, C , Pérez, O, Casis, O, Duarte, J, Pérez-Vizcaino, F, Delpón, E, Tamargo, J. Br. J. Pharmacol. - 109 (3) : 873-879 (PMID: 7689408)
1 mar | 1993 [Anti-arrhythmia agents: classification, mode of action, and therapeutic usefulness]. Tamargo, J, Delpón, E, Valenzuela, C , Pérez, O. Rev Clin Esp - 192 (4) : 189-196 (PMID: 8386844)
1 mar | 1993 [Cardiac arrhythmias (III). The classification of anti-arrhythmia drugs in the 90s: a focus for the cardiologist]. Tamargo, J, Valenzuela, C , Delpón, E. Rev Esp Cardiol - 46 (3) : 183-194 (PMID: 8387683)
1 ene | 1993 Electrophysiological effects of the combination of imipramine and desipramine in guinea pig papillary muscles. Delpón, E, Valenzuela, C , Pérez, O, Tamargo, J. J. Cardiovasc. Pharmacol. - 21 (1) : 13-20 (PMID: 7678668)
1 nov | 1992 New insights into the pharmacology of sodium channel blockers. Tamargo, J, Valenzuela, C , Delpón, E. Eur. Heart J. - 13 Suppl F : 2-13 (PMID: 1335869)
1 oct | 1992 Electrophysiological effects of CRE-1087 in guinea-pig ventricular muscles. Delpón, E, Valenzuela, C , Pérez, O, Tamargo, J. Br. J. Pharmacol. - 107 (2) : 515-520 (PMID: 1422597)
1 jun | 1991 Electrophysiological effects of the combination of mexiletine and flecainide in guinea-pig ventricular fibres. Delpón, E, Valenzuela, C , Tamargo, J. Br. J. Pharmacol. - 103 (2) : 1411-1416 (PMID: 1909200)
1 jun | 1991 Tonic and frequency-dependent Vmax block induced by (S)-nafenodone, a new antidepressant drug, in guinea-pig papillary muscles. Delpón, E, Valenzuela, C , Carrón, R, Pérez-Vizcaino, F, Tamargo, J. Naunyn Schmiedebergs Arch. Pharmacol. - 343 (6) : 638-644 (PMID: 1944605)
1 jun | 1991 Voltage- and use-dependent modulation of calcium channel current in guinea pig ventricular cells by amiodarone and des-oxo-amiodarone. Valenzuela, C , Bennett, PB. J. Cardiovasc. Pharmacol. - 17 (6) : 894-902 (PMID: 1714012)
1 mar | 1990 Tonic and frequency-dependent Vmax block induced by imipramine in guinea pig ventricular muscle fibers. Delpón, E, Valenzuela, C , Tamargo, J. J. Cardiovasc. Pharmacol. - 15 (3) : 414-420 (PMID: 1691365)
1 ene | 1990 [Amiodarone: new concepts on its anti-arrhythmic effect]. Tamargo, J, Valenzuela, C , Delpón, E. An Med Interna - 7 (1) : 42-50 (PMID: 2103198)
1 nov | 1989 Electrophysiologic interactions between mexiletine-quinidine and mexiletine-ropitoin in guinea pig papillary muscle. Valenzuela, C , Sanchez-Chapula, J. J. Cardiovasc. Pharmacol. - 14 (5) : 783-789 (PMID: 2481194)
1 sep | 1989 Electrophysiologic interactions between mexiletine and propafenone in guinea pig papillary muscles. Valenzuela, C , Delpón, E, Tamargo, J. J. Cardiovasc. Pharmacol. - 14 (3) : 351-357 (PMID: 2476612)
1 abr | 1989 Electrophysiological effects of E-3753, a new antiarrhythmic drug, in guinea-pig ventricular muscle. Delpón, E, Valenzuela, C , Tamargo, J. Br. J. Pharmacol. - 96 (4) : 970-976 (PMID: 2743087)
1 oct | 1988 Tonic and phasic Vmax block induced by 5-hydroxypropafenone in guinea pig ventricular muscles. Valenzuela, C , Delpón, E, Tamargo, J. J. Cardiovasc. Pharmacol. - 12 (4) : 423-431 (PMID: 2465442)
1 jun | 1988 Comparison of six new antidepressants on isolated rat atria. Manzanares, J, Valenzuela, C , Delgado, C , Tamargo, J. Arzneimittelforschung - 38 (6) : 805-809 (PMID: 3178921)
1 nov | 1987 Electrophysiological effects of 5-hydroxypropafenone on guinea pig ventricular muscle fibers. Valenzuela, C , Delgado, C , Tamargo, J. J. Cardiovasc. Pharmacol. - 10 (5) : 523-529 (PMID: 2447400)
1 ago | 1987 Comparative effects of oxodipine and nifedipine in the isolated guinea-pig heart. Tejerina, T, Delgado, C , Valenzuela, C , Tamargo, J. Arch Int Pharmacodyn Ther - 288 (2) : 186-199 (PMID: 3675081)
1 mar | 1987 Effects of 5-hydroxy-propafenone in guinea-pig atrial fibres. Delgado, C , Tamargo, J, Tejerina, T, Valenzuela, C . Br. J. Pharmacol. - 90 (3) : 575-582 (PMID: 2882804)
1 feb | 1986 Electrophysiological effects of amoxapine in untreated and in amoxapine-pretreated rat atria. Delgado, C , Manzanares, J, Tamargo, J, Valenzuela, C . Br. J. Pharmacol. - 87 (2) : 317-325 (PMID: 3955303)
1 nov | 1985 Negative inotropic effect of somatostatin in guinea-pig atrial fibres. Diez, J, Tamargo, J, Valenzuela, C . Br. J. Pharmacol. - 86 (3) : 547-555 (PMID: 2866001)