3 Mar | 2025 Health position paper and redox perspectives - Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases. Cuadrado, A , Cazalla, E , Bach, A, Bathish, B, Naidu, SD, DeNicola, GM, Dinkova-Kostova, AT, Fernández-Ginés, R , Grochot-Przeczek, A, Hayes, JD, Kensler, TW, León, R, Liby, KT, López, MG, Manda, G, Shivakumar, AK, Hakomäki, H, Moerland, JA, Motohashi, H, Rojo, AI , Sykiotis, GP, Taguchi, K, Valverde, ÁM , Yamamoto, M, Levonen, AL. Redox Biol (PMID: 40059038) (doi:10.1016/j.redox.2025.103569)
19 Jan | 2025 Corrigendum to "Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases" [Redox Biol. 79 (2025) 103464]. Rojo, AI , Buttari, B, Cadenas, S, Carlos, AR, Cuadrado, A , Falcão, AS, López, MG, Georgiev, MI, Grochot-Przeczek, A, Gumeni, S, Jiménez-Villegas, J , Horbanczuk, JO, Konu, O, Lastres-Becker, I , Levonen, AL, Maksimova, V, Michaeloudes, C, Mihaylova, LV, Mickael, ME, Milisav, I, Miova, B, Rada, P , Santos, M, Seabra, MC, Strac, DS, Tenreiro, S, Trougakos, IP, Dinkova-Kostova, AT. Redox Biol (PMID: 39833011) (doi:10.1016/j.redox.2025.103496)
16 Dec | 2024 Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases. Rojo, AI , Buttari, B, Cadenas, S, Carlos, AR, Cuadrado, A , Falcão, AS, López, MG, Georgiev, MI, Grochot-Przeczek, A, Gumeni, S, Jimenez-Villegas, J, Horbanczuk, JO, Konu, O, Lastres-Becker, I , Levonen, AL, Maksimova, V, Michaeloudes, C, Mihaylova, LV, Mickael, ME, Milisav, I, Miova, B, Rada, P , Santos, M, Seabra, MC, Strac, DS, Tenreiro, S, Trougakos, IP, Dinkova-Kostova, AT. Redox Biol - 79 : 103464 (PMID: 39709790) (doi:10.1016/j.redox.2024.103464)
27 Nov | 2024 NRF2 activation by 6-MSITC increases the generation of neuroprotective, soluble α amyloid precursor protein by inducing the metalloprotease gene ADAM17. Carnicero-Senabre, D , Jiménez-Villegas, J , Álvarez-Garrote, S, Escoll, M , Cuadrado, A , Rojo, AI . Free Radic Biol Med (PMID: 39613049) (doi:10.1016/j.freeradbiomed.2024.11.048)
3 Jan | 2024 Specific targeting of the NRF2/β-TrCP axis promotes beneficial effects in NASH. Fernández-Ginés, R , Encinar, JA, Escoll, M , Carnicero-Senabre, D , Jiménez-Villegas, J , García-Yagüe, ÁJ , González-Rodríguez, Á , Garcia-Martinez, I , M Valverde, Á , Rojo, AI , Cuadrado, A . Redox Biol - 69 : 103027 (PMID: 38184999) (doi:10.1016/j.redox.2024.103027)
25 Sep | 2022 Dipeptide Repeat Pathology in C9orf72-ALS Is Associated with Redox, Mitochondrial and NRF2 Pathway Imbalance. Jiménez-Villegas, J , Kirby, J, Mata, A, Cadenas, S, Turner, MR, Malaspina, A, Shaw, PJ, Cuadrado, A , Rojo, AI . Antioxidants (Basel) - 11 (10) (PMID: 36290620) (doi:10.3390/antiox11101897)
12 Sep | 2022 Overlooked and valuable facts to know in the NRF2/KEAP1 field. Kopacz, A, Rojo, AI , Patibandla, C, Lastra-Martínez, D , Piechota-Polanczyk, A, Kloska, D, Jozkowicz, A, Sutherland, C, Cuadrado, A , Grochot-Przeczek, A. Free Radic Biol Med - 192 : 37-49 (PMID: 36100148) (doi:10.1016/j.freeradbiomed.2022.08.044)
1 Sep | 2022 Corrigendum to "An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver" [Redox Biol. 55 (2022) 102396/PMID: 35839629]. Fernández-Ginés, R , Encinar, JA, Hayes, JD, Oliva, B, Rodríguez-Franco, MI, Rojo, AI , Cuadrado, A . Redox Biol - 55 : 102428 (PMID: 35931641) (doi:10.1016/j.redox.2022.102428)
11 Jul | 2022 An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver. Fernández-Ginés, R , Encinar, JA, Hayes, JD, Oliva, B, Rodríguez-Franco, MI, Rojo, AI , Cuadrado, A . Redox Biol - 55 : 102396 (PMID: 35839629) (doi:10.1016/j.redox.2022.102396)
20 Nov | 2021 Whole Blood Expression Pattern of Inflammation and Redox Genes in Mild Alzheimer's Disease. Milanesi, E, Dobre, M, Cucos, CA, Rojo, AI , Jiménez-Villegas, J , Capetillo-Zarate, E, Matute, C, Piñol-Ripoll, G, Manda, G, Cuadrado, A . J Inflamm Res - 14 : 6085-6102 (PMID: 34848989) (doi:10.2147/JIR.S334337)
24 Jul | 2021 NRF2 as a therapeutic opportunity to impact in the molecular roadmap of ALS. Jiménez-Villegas, J , Ferraiuolo, L, Mead, RJ, Shaw, PJ, Cuadrado, A , Rojo, AI . Free Radic Biol Med - 173 : 125-141 (PMID: 34314817) (doi:10.1016/j.freeradbiomed.2021.07.022)
8 Feb | 2021 Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Klionsky, DJ, [ .., ], Bartolome, A , [ .., ], Cuadrado, A , [ .., ], Escalante, R , [ .., ], García-Sanz, P , [ .., ], Lastres-Becker, I , [ .., ], León, Y , [ .., ], Martin-Sanz, P , [ .., ], Pajares, M , [ .., ], Rojo, AI , [ .., ], Valverde, AM , [ .., ], Varela-Nieto, I , [ .., ], Villalobo, A , [ .., ], Vincent, O , [ .., ], Tong, CK. Autophagy (PMID: 33634751) (doi:10.1080/15548627.2020.1797280)
1 Oct | 2020 On the Clinical Pharmacology of Reactive Oxygen Species. Casas, AI, Nogales, C, Mucke, HAM, Petraina, A, Cuadrado, A , Rojo, AI , Ghezzi, P, Jaquet, V, Augsburger, F, Dufrasne, F, Soubhye, J, Deshwal, S, Di Sante, M, Kaludercic, N, Di Lisa, F, Schmidt, HHHW. Pharmacol. Rev. - 72 (4) : 801-828 (PMID: 32859763) (doi:10.1124/pr.120.019422)
14 Jul | 2020 Can Activation of NRF2 Be a Strategy against COVID-19? Cuadrado, A , Pajares, M , Benito, C , Jiménez-Villegas, J , Escoll, M , Fernández-Ginés, R , Garcia Yagüe, AJ , Lastra, D , Manda, G, Rojo, AI , Dinkova-Kostova, AT. Trends Pharmacol. Sci. (PMID: 32711925) (doi:10.1016/j.tips.2020.07.003)
14 Jul | 2020 Inflammation in Parkinson's Disease: Mechanisms and Therapeutic Implications. Pajares, M , I Rojo, A , Manda, G, Boscá, L , Cuadrado, A . Cells - 9 (7) (PMID: 32674367) (doi:10.3390/cells9071687)
28 Feb | 2020 Nordihydroguaiaretic Acid: From Herbal Medicine to Clinical Development for Cancer and Chronic Diseases. Manda, G, Rojo, AI , Martínez-Klimova, E, Pedraza-Chaverri, J, Cuadrado, A . Front Pharmacol - 11 : 151 (PMID: 32184727) (doi:10.3389/fphar.2020.00151)
2 Jan | 2020 Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomas. Escoll, M , Lastra, D , Pajares, M , Robledinos-Antón, N , Rojo, AI , Fernández-Ginés, R , Mendiola, M , Martínez-Marín, V, Esteban, I, López-Larrubia, P , Gargini, R, Cuadrado, A . Redox Biol - 30 : 101425 (PMID: 31918259) (doi:10.1016/j.redox.2019.101425)
1 Apr | 2019 Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases. Cuadrado, A , Rojo, AI , Wells, G, Hayes, JD, Cousin, SP, Rumsey, WL, Attucks, OC, Franklin, S, Levonen, AL, Kensler, TW, Dinkova-Kostova, AT. Nat Rev Drug Discov - 18 (4) : 295-317 (PMID: 30610225) (doi:10.1038/s41573-018-0008-x)
1 Sep | 2018 Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy. Rojo, AI , Pajares, M , García-Yagüe, AJ , Buendia, I, Van Leuven, F, Yamamoto, M, López, MG, Cuadrado, A . Redox Biol - 18 : 173-180 (PMID: 30029164) (doi:10.1016/j.redox.2018.07.006)
26 Jul | 2018 Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A. Pajares, M , Rojo, AI , Arias, E, Díaz-Carretero, A, Cuervo, AM, Cuadrado, A . Autophagy - 14 (8) : 1310-1322 (PMID: 29950142) (doi:10.1080/15548627.2018.1474992)
1 Apr | 2018 Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach. Cuadrado, A , Manda, G, Hassan, A, Alcaraz, MJ, Barbas, C, Daiber, A, Ghezzi, P, León, R, López, MG, Oliva, B, Pajares, M , Rojo, AI , Robledinos-Antón, N , Valverde, AM , Guney, E, Schmidt, HHHW. Pharmacol. Rev. - 70 (2) : 348-383 (PMID: 29507103) (doi:10.1124/pr.117.014753)
19 Oct | 2017 Amyloid beta synaptotoxicity is Wnt-planar cell polarity dependent and blocked by fasudil. Sellers, KJ, Elliott, C, Jackson, J, Ghosh, A, Ribe, E, Rojo-Sanchís, A , Jarosz-Griffiths, HH, Watson, IA, Xia, W, Semenov, M, Morin, P, Hooper, NM, Porter, R, Preston, J, Al-Shawi, R, Baillie, G, Lovestone, S, Cuadrado, A , Harte, M, Simons, P, Srivastava, DP, Killick, R. Alzheimers Dement (PMID: 29055813) (doi:10.1016/j.jalz.2017.09.008)
1 Oct | 2017 NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology. Rojo, AI , Pajares, M , Rada, P , Nuñez, A, Nevado-Holgado, AJ, Killik, R, Van Leuven, F, Ribe, E, Lovestone, S, Yamamoto, M, Cuadrado, A . Redox Biol - 13 : 444-451 (PMID: 28704727) (doi:10.1016/j.redox.2017.07.006)
1 Oct | 2017 Transcription factor NRF2 controls the fate of neural stem cells in the subgranular zone of the hippocampus. Robledinos-Antón, N , Rojo, AI , Ferreiro, E, Núñez, Á, Krause, KH, Jaquet, V, Cuadrado, A . Redox Biol - 13 : 393-401 (PMID: 28667908) (doi:10.1016/j.redox.2017.06.010)
31 Mar | 2017 Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's disease. Gameiro, I, Michalska, P, Tenti, G, Cores, Á, Buendia, I, Rojo, AI , Georgakopoulos, ND, Hernández-Guijo, JM, Teresa Ramos, M, Wells, G, López, MG, Cuadrado, A , Menéndez, JC, León, R. Sci Rep - 7 : 45701 (PMID: 28361919) (doi:10.1038/srep45701)
10 Jan | 2017 Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases. Pajares, M , Cuadrado, A , Rojo, AI . Redox Biol - 11 : 543-553 (PMID: 28104575) (doi:10.1016/j.redox.2017.01.006)
2 Oct | 2016 Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes. Pajares, M , Jiménez-Moreno, N, García-Yagüe, ÁJ , Escoll, M , de Ceballos, ML, Van Leuven, F, Rábano, A, Yamamoto, M, Rojo, AI , Cuadrado, A . Autophagy - 12 (10) : 1902-1916 (PMID: 27427974) (doi:10.1080/15548627.2016.1208889)
1 Mar | 2015 WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes. Rada, P , Rojo, AI , Offergeld, A, Feng, GJ, Velasco-Martín, JP, González-Sancho, JM , Valverde, ÁM , Dale, T, Regadera, J, Cuadrado, A . Antioxid. Redox Signal. - 22 (7) : 555-571 (PMID: 25336178) (doi:10.1089/ars.2014.6040)
20 Dec | 2014 The PTEN/NRF2 axis promotes human carcinogenesis. Rojo, AI , Rada, P , Mendiola, M , Ortega-Molina, A, Wojdyla, K, Rogowska-Wrzesinska, A, Hardisson, D, Serrano, M, Cuadrado, A . Antioxid. Redox Signal. - 21 (18) : 2498-2514 (PMID: 24892215) (doi:10.1089/ars.2014.5843)
22 Feb | 2013 Nuclear import and export signals control the subcellular localization of Nurr1 protein in response to oxidative stress. García-Yagüe, ÁJ , Rada, P , Rojo, AI , Lastres-Becker, I , Cuadrado, A . J. Biol. Chem. - 288 (8) : 5506-5517 (PMID: 23283970) (doi:10.1074/jbc.M112.439190)
1 Sep | 2012 Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis. Rada, P , Rojo, AI , Evrard-Todeschi, N, Innamorato, NG , Cotte, A, Jaworski, T, Tobón-Velasco, JC, Devijver, H, García-Mayoral, MF, Van Leuven, F, Hayes, JD, Bertho, G, Cuadrado, A . Mol. Cell. Biol. - 32 (17) : 3486-3499 (PMID: 22751928) (doi:10.1128/MCB.00180-12)
15 Jan | 2012 Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3. Rojo, AI , Medina-Campos, ON, Rada, P , Zúñiga-Toalá, A, López-Gazcón, A, Espada, S , Pedraza-Chaverri, J, Cuadrado, A . Free Radic. Biol. Med. - 52 (2) : 473-487 (PMID: 22142471) (doi:10.1016/j.freeradbiomed.2011.11.003)
15 Jun | 2011 Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism. Jazwa, A , Rojo, AI , Innamorato, NG , Hesse, M, Fernández-Ruiz, J, Cuadrado, A . Antioxid. Redox Signal. - 14 (12) : 2347-2360 (PMID: 21254817) (doi:10.1089/ars.2010.3731)
1 Mar | 2011 SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner. Rada, P , Rojo, AI , Chowdhry, S, McMahon, M, Hayes, JD, Cuadrado, A . Mol. Cell. Biol. - 31 (6) : 1121-1133 (PMID: 21245377) (doi:10.1128/MCB.01204-10)
1 Aug | 2010 The purinergic P2Y(13) receptor activates the Nrf2/HO-1 axis and protects against oxidative stress-induced neuronal death. Espada, S , Ortega, F, Molina-Jijón, E, Rojo, AI , Pérez-Sen, R, Pedraza-Chaverri, J, Miras-Portugal, MT, Cuadrado, A . Free Radic. Biol. Med. - 49 (3) : 416-426 (PMID: 20447456) (doi:10.1016/j.freeradbiomed.2010.04.031)
28 Jul | 2010 Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1. Innamorato, NG , Jazwa, A , Rojo, AI , García, C, Fernández-Ruiz, J, Grochot-Przeczek, A, Stachurska, A, Jozkowicz, A, Dulak, J, Cuadrado, A . PLoS ONE - 5 (7) : e11838 (PMID: 20676377) (doi:10.1371/journal.pone.0011838)
27 Apr | 2010 Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease. Rojo, AI , Innamorato, NG , Martín-Moreno, AM, De Ceballos, ML, Yamamoto, M, Cuadrado, A . Glia - 58 (5) : 588-598 (PMID: 19908287) (doi:10.1002/glia.20947)
13 Jan | 2010 Fibroblast growth factor-1 within the ventral tegmental area participates in motor sensitizing effects of morphine. Flores, JA, Galan-Rodriguez, B, Rojo, AI , Ramiro-Fuentes, S, Cuadrado, A , Fernandez-Espejo, E. Neuroscience - 165 (1) : 198-211 (PMID: 19819303) (doi:10.1016/j.neuroscience.2009.10.009)
7 Aug | 2009 The muscarinic M1 receptor activates Nrf2 through a signaling cascade that involves protein kinase C and inhibition of GSK-3beta: connecting neurotransmission with neuroprotection. Espada, S , Rojo, AI , Salinas, M , Cuadrado, A . J. Neurochem. - 110 (3) : 1107-1119 (PMID: 19558456) (doi:10.1111/j.1471-4159.2009.06208.x)
15 Jun | 2009 Heme oxygenase-1 induction modulates microsomal prostaglandin E synthase-1 expression and prostaglandin E(2) production in osteoarthritic chondrocytes. Megías, J, Guillén, MI, Clérigues, V, Rojo, AI , Cuadrado, A , Castejón, MA, Gomar, F, Alcaraz, MJ. Biochem. Pharmacol. - 77 (12) : 1806-1813 (PMID: 19428335) (doi:10.1016/j.bcp.2009.03.009)
1 Sep | 2008 Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death. Rojo, AI , Rada, P , Egea, J, Rosa, AO, López, MG, Cuadrado, A . Mol. Cell. Neurosci. - 39 (1) : 125-132 (PMID: 18619545) (doi:10.1016/j.mcn.2008.06.007)
15 Jul | 2008 Nrf2-mediated haeme oxygenase-1 up-regulation induced by cobalt protoporphyrin has antinociceptive effects against inflammatory pain in the formalin test in mice. Rosa, AO, Egea, J, Lorrio, S, Rojo, AI , Cuadrado, A , López, MG. Pain - 137 (2) : 332-339 (PMID: 17964723) (doi:10.1016/j.pain.2007.09.015)
1 Jul | 2008 The transcription factor Nrf2 is a therapeutic target against brain inflammation. Innamorato, NG , Rojo, AI , García-Yagüe, AJ , Yamamoto, M, de Ceballos, ML, Cuadrado, A . J. Immunol. - 181 (1) : 680-689 (PMID: 18566435)
7 May | 2008 Heme oxygenase-1 as a therapeutic target in neurodegenerative diseases and brain infections. Cuadrado, A , Rojo, AI . Curr. Pharm. Des. - 14 (5) : 429-442 (PMID: 18289070)
28 Apr | 2008 GSK-3beta down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress. Rojo, AI , Sagarra, MR , Cuadrado, A . J. Neurochem. - 105 (1) : 192-202 (PMID: 18005231) (doi:10.1111/j.1471-4159.2007.05124.x)
1 Nov | 2007 Chronic inhalation of rotenone or paraquat does not induce Parkinson's disease symptoms in mice or rats. Rojo, AI , Cavada, C, de Sagarra, MR , Cuadrado, A . Exp. Neurol. - 208 (1) : 120-126 (PMID: 17880941) (doi:10.1016/j.expneurol.2007.07.022)
27 Oct | 2006 Persistent penetration of MPTP through the nasal route induces Parkinson's disease in mice. Rojo, AI , Montero, C, Salazar, M , Close, RM, Fernández-Ruiz, J, Sánchez-González, MA, de Sagarra, MR , Jackson-Lewis, V, Cavada, C, Cuadrado, A . Eur. J. Neurosci. - 24 (7) : 1874-1884 (PMID: 17067291) (doi:10.1111/j.1460-9568.2006.05060.x)
15 Jul | 2006 Regulation of heme oxygenase-1 gene expression through the phosphatidylinositol 3-kinase/PKC-zeta pathway and Sp1. Rojo, AI , Salina, M, Salazar, M , Takahashi, S, Suske, G, Calvo, V , de Sagarra, MR , Cuadrado, A . Free Radic. Biol. Med. - 41 (2) : 247-261 (PMID: 16814105) (doi:10.1016/j.freeradbiomed.2006.04.002)
26 May | 2006 Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2. Salazar, M , Rojo, AI , Velasco, D , de Sagarra, RM , Cuadrado, A . J. Biol. Chem. - 281 (21) : 14841-14851 (PMID: 16551619) (doi:10.1074/jbc.M513737200)
3 Dec | 2004 Protein kinase Akt/PKB phosphorylates heme oxygenase-1 in vitro and in vivo. Salinas, M , Wang, J, Rosa de Sagarra, M, Martín, D , Rojo, AI , Martin-Perez, J , Ortiz de Montellano, PR, Cuadrado, A . FEBS Lett. - 578 (1-2) : 90-94 (PMID: 15581622) (doi:10.1016/j.febslet.2004.10.077)
18 Aug | 2004 Regulation of Cu/Zn-superoxide dismutase expression via the phosphatidylinositol 3 kinase/Akt pathway and nuclear factor-kappaB. Rojo, AI , Salinas, M , Martín, D , Perona, R , Cuadrado, A . J. Neurosci. - 24 (33) : 7324-7334 (PMID: 15317858) (doi:10.1523/JNEUROSCI.2111-04.2004)
16 Apr | 2004 Signaling through the leukocyte integrin LFA-1 in T cells induces a transient activation of Rac-1 that is regulated by Vav and PI3K/Akt-1. Sánchez-Martín, L, Sánchez-Sánchez, N, Gutiérrez-López, MD, Rojo, AI , Vicente-Manzanares, M, Pérez-Alvarez, MJ, Sánchez-Mateos, P, Bustelo, XR, Cuadrado, A , Sánchez-Madrid, F, Rodríguez-Fernández, JL, Cabañas, C. J. Biol. Chem. - 279 (16) : 16194-16205 (PMID: 14960575) (doi:10.1074/jbc.M400905200)
5 Mar | 2004 Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol. Martin, D, Rojo, AI , Salinas, M , Diaz, R, Gallardo, G, Alam, J, De Galarreta, CM, Cuadrado, A . J. Biol. Chem. - 279 (10) : 8919-8929 (PMID: 14688281) (doi:10.1074/jbc.M309660200)