12 Aug | 2024 Alx3 deficiency disrupts energy homeostasis, alters body composition, and impairs hypothalamic regulation of food intake. Mirasierra, M , Fernández-Pérez, A , Lizarbe, B , Keiran, N, Ruiz-Cañas, L , Casarejos, MJ, Cerdán, S , Vendrell, J, Fernández-Veledo, S, Vallejo, M . Cell Mol Life Sci - 81 (1) : 343 (PMID: 39129011) (doi:10.1007/s00018-024-05384-z)
21 Mar | 2023 SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression. Villanueva-Carmona, T, Cedó, L, Madeira, A, Ceperuelo-Mallafré, V, Rodríguez-Peña, MM, Núñez-Roa, C, Maymó-Masip, E, Repollés-de-Dalmau, M, Badia, J, Keiran, N, Mirasierra, M , Pimenta-Lopes, C, Sabadell-Basallote, J, Bosch, R, Caubet, L, Escolà-Gil, JC, Fernández-Real, JM, Vilarrasa, N, Ventura, F, Vallejo, M , Vendrell, J, Fernández-Veledo, S. Cell Metab (PMID: 36977414) (doi:10.1016/j.cmet.2023.03.004)
11 Jan | 2022 Restricting feeding to dark phase fails to entrain circadian activity and energy expenditure oscillations in Pitx3-mutant Aphakia mice. Fernández-Pérez, A , Sanz-Magro, A, Moratalla, R, Vallejo, M . Cell Rep - 38 (2) : 110241 (PMID: 35021074) (doi:10.1016/j.celrep.2021.110241)
21 Dec | 2021 The second-generation antipsychotic drug aripiprazole modulates the serotonergic system in pancreatic islets and induces beta cell dysfunction in female mice. Grajales, D , Vázquez, P , Ruíz-Rosario, M, Tudurí, E, Mirasierra, M , Ferreira, V , Hitos, AB , Koller, D, Zubiaur, P, Cigudosa, JC, Abad-Santos, F, Vallejo, M , Quesada, I, Tirosh, B, Leibowitz, G, Valverde, ÁM . Diabetologia (PMID: 34932133) (doi:10.1007/s00125-021-05630-0)
17 May | 2021 BACE2 suppression in mice aggravates the adverse metabolic consequences of an obesogenic diet. Díaz-Catalán, D, Alcarraz-Vizán, G, Castaño, C , de Pablo, S, Rodríguez-Comas, J, Fernández-Pérez, A , Vallejo, M , Ramírez, S, Claret, M, Parrizas, M, Novials, A, Servitja, JM. Mol Metab (PMID: 34015524) (doi:10.1016/j.molmet.2021.101251)
31 Mar | 2021 Increasing breast milk betaine modulates Akkermansia abundance in mammalian neonates and improves long-term metabolic health. Ribo, S, Sánchez-Infantes, D, Martinez-Guino, L, García-Mantrana, I, Ramon-Krauel, M, Tondo, M, Arning, E, Nofrarías, M, Osorio-Conles, Ó, Fernández-Pérez, A , González-Torres, P, Cebrià, J, Gavaldà-Navarro, A, Chenoll, E, Isganaitis, E, Villarroya, F, Vallejo, M , Segalés, J, Jiménez-Chillarón, JC, Bottiglieri, T, Demerath, EW, Fields, DA, Collado, MC, Lerin, C. Sci Transl Med - 13 (587) (PMID: 33790021) (doi:10.1126/scitranslmed.abb0322)
3 Mar | 2021 GRK2 regulates GLP-1R-mediated early phase insulin secretion in vivo. Arcones, AC, Vila-Bedmar, R, Mirasierra, M , Cruces-Sande, M, Vallejo, M , Jones, B, Tomas, A, Mayor, F, Murga, C. BMC Biol - 19 (1) : 40 (PMID: 33658023) (doi:10.1186/s12915-021-00966-w)
7 Jan | 2021 Neonatal overfeeding during lactation rapidly and permanently misaligns the hepatic circadian rhythm and programmes adult NAFLD. Ribas-Aulinas, F, Ribo, S, Parra-Vargas, M, Fernández-Pérez, A , Cebrià, J, Guardiola-Perello, M, Ramon-Krauel, M, Lerin, C, Diaz, R, Kalko, SG, Vallejo, M , Díez-Noguera, A, Cambras, T, Jimenez-Chillaron, JC. Mol Metab (PMID: 33422644) (doi:10.1016/j.molmet.2021.101162)
16 Nov | 2020 Delivery of muscle-derived exosomal miRNAs induced by HIIT improves insulin sensitivity through down-regulation of hepatic FoxO1 in mice. Castaño, C , Mirasierra, M , Vallejo, M , Novials, A, Párrizas, M. Proc Natl Acad Sci U S A (PMID: 33199621) (doi:10.1073/pnas.2016112117)
14 Oct | 2020 The Value of Mouse Models of Rare Diseases: A Spanish Experience. Murillo-Cuesta, S , Artuch, R, Asensio, F, de la Villa, P, Dierssen, M, Enríquez, JA, Fillat, C, Fourcade, S, Ibáñez, B, Montoliu, L, Oliver, E, Pujol, A, Salido, E, Vallejo, M , Varela-Nieto, I . Front Genet - 11 : 583932 (PMID: 33173540) (doi:10.3389/fgene.2020.583932)
15 Jul | 2020 Diabetes Causes Dysfunctional Dopamine Neurotransmission Favoring Nigrostriatal Degeneration in Mice. Pérez-Taboada, I , Alberquilla, S, Martín, ED, Anand, R, Vietti-Michelina, S, Tebeka, NN, Cantley, J, Cragg, SJ, Moratalla, R, Vallejo, M . Mov. Disord. (PMID: 32666590) (doi:10.1002/mds.28124)
28 Feb | 2020 rMSIproc: an R package for mass spectrometry imaging data processing. Ràfols, P, Heijs, B, Del Castillo, E, Yanes, O, McDonnell, LA, Brezmes, J, Pérez-Taboada, I , Vallejo, M , García-Altares, M, Correig, X. Bioinformatics (PMID: 32108859) (doi:10.1093/bioinformatics/btaa142)
10 Dec | 2019 Hypomorphic Expression of Pitx3 Disrupts Circadian Clocks and Prevents Metabolic Entrainment of Energy Expenditure. Del Río-Martín, A , Pérez-Taboada, I , Fernández-Pérez, A , Moratalla, R, de la Villa, P, Vallejo, M . Cell Rep - 29 (11) : 3678-3692.e4 (PMID: 31825844) (doi:10.1016/j.celrep.2019.11.027)
3 Sep | 2019 Systemic Glucose Administration Alters Water Diffusion and Microvascular Blood Flow in Mouse Hypothalamic Nuclei - An fMRI Study. Lizarbe, B , Fernández-Pérez, A , Caz, V, Largo, C, Vallejo, M , López-Larrubia, P , Cerdán, S . Front Neurosci - 13 : 921 (PMID: 31551685) (doi:10.3389/fnins.2019.00921)
29 May | 2018 Epigenetic programming at the Mogat1 locus may link neonatal overnutrition with long-term hepatic steatosis and insulin resistance. Ramon-Krauel, M, Pentinat, T, Bloks, VW, Cebrià, J, Ribo, S, Pérez-Wienese, R, Vilà, M, Palacios-Marin, I, Fernández-Pérez, A , Vallejo, M , Téllez, N, Rodríguez, MÀ, Yanes, O, Lerin, C, Díaz, R, Plosch, T, Tietge, UJF, Jimenez-Chillaron, JC. FASEB J. (PMID: 29812971) (doi:10.1096/fj.201700717RR)
24 Mar | 2017 Embryonic defence mechanisms against glucose-dependent oxidative stress require enhanced expression of Alx3 to prevent malformations during diabetic pregnancy. García-Sanz, P , Mirasierra, M , Moratalla, R, Vallejo, M . Sci Rep - 7 (1) : 389 (PMID: 28341857) (doi:10.1038/s41598-017-00334-1)
20 Mar | 2017 Role of muscle IL-6 in gender-specific metabolism in mice. Molinero, A, Fernandez-Perez, A , Mogas, A, Giralt, M, Comes, G, Fernandez-Gayol, O, Vallejo, M , Hidalgo, J. PLoS ONE - 12 (3) : e0173675 (PMID: 28319140) (doi:10.1371/journal.pone.0173675)
24 Nov | 2016 Developmental mechanisms of stripe patterns in rodents. Mallarino, R, Henegar, C, Mirasierra, M , Manceau, M, Schradin, C, Vallejo, M , Beronja, S, Barsh, GS, Hoekstra, HE. Nature - 539 (7630) : 518-523 (PMID: 27806375) (doi:10.1038/nature20109)
1 Apr | 2016 Glucose-dependent downregulation of glucagon gene expression mediated by selective interactions between ALX3 and PAX6 in mouse alpha cells. Mirasierra, M , Vallejo, M . Diabetologia - 59 (4) : 766-775 (PMID: 26739814) (doi:10.1007/s00125-015-3849-4)
15 Jan | 2015 Activation of DREAM (downstream regulatory element antagonistic modulator), a calcium-binding protein, reduces L-DOPA-induced dyskinesias in mice. Ruiz-DeDiego, I, Mellstrom, B, Vallejo, M , Naranjo, JR, Moratalla, R. Biol. Psychiatry - 77 (2) : 95-9105 (PMID: 24857398) (doi:10.1016/j.biopsych.2014.03.023)
15 Oct | 2014 Pdx1 and USF transcription factors co-ordinately regulate Alx3 gene expression in pancreatic β-cells. Fernández-Pérez, A , Vallejo, M . Biochem. J. - 463 (2) : 287-296 (PMID: 25040025) (doi:10.1042/BJ20140643)
15 Feb | 2013 Differential configurations involving binding of USF transcription factors and Twist1 regulate Alx3 promoter activity in mesenchymal and pancreatic cells. García-Sanz, P , Fernández-Pérez, A , Vallejo, M . Biochem. J. - 450 (1) : 199-208 (PMID: 23181698) (doi:10.1042/BJ20120962)
1 Apr | 2012 Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging. González-Rodríguez, A , Más-Gutierrez, JA, Mirasierra, M , Fernandez-Pérez, A , Lee, YJ, Ko, HJ, Kim, JK, Romanos, E, Carrascosa, JM, Ros, M, Vallejo, M , Rondinone, CM, Valverde, AM . Aging Cell - 11 (2) : 284-296 (PMID: 22221695) (doi:10.1111/j.1474-9726.2011.00786.x)
1 Mar | 2011 The aristaless-like homeobox protein Alx3 as an etiopathogenic factor for diabetes mellitus. Vallejo, M . Islets - 3 (2) : 66-68 (PMID: 21350340)
23 Feb | 2011 Regulation of somatostatin gene expression by brain derived neurotrophic factor in fetal rat cerebrocortical cells. Sánchez-Muñoz, I, Sánchez-Franco, F, Vallejo, M , Fernández-Pérez, A , Palacios, N, Fernández, M, Sánchez-Grande, M, Cacicedo, L. Brain Res. - 1375 : 28-40 (PMID: 21184749) (doi:10.1016/j.brainres.2010.12.031)
1 Feb | 2011 Alx3-deficient mice exhibit decreased insulin in beta cells, altered glucose homeostasis and increased apoptosis in pancreatic islets. Mirasierra, M , Fernández-Pérez, A , Díaz-Prieto, N , Vallejo, M . Diabetologia - 54 (2) : 403-414 (PMID: 21104068) (doi:10.1007/s00125-010-1975-6)
15 Aug | 2010 Alx3-deficient mice exhibit folic acid-resistant craniofacial midline and neural tube closure defects. Lakhwani, S , García-Sanz, P , Vallejo, M . Dev. Biol. - 344 (2) : 869-880 (PMID: 20534379) (doi:10.1016/j.ydbio.2010.06.002)
25 Mar | 2010 Activity-dependent somatostatin gene expression is regulated by cAMP-dependent protein kinase and Ca2+-calmodulin kinase pathways. Sánchez-Muñoz, I, Sánchez-Franco, F, Vallejo, M , Fernández-Pérez, A , Palacios, N, Fernández, M, Cacicedo, L. J. Neurosci. Res. - 88 (4) : 825-836 (PMID: 19859966) (doi:10.1002/jnr.22264)
1 Apr | 2009 PACAP signaling to DREAM: a cAMP-dependent pathway that regulates cortical astrogliogenesis. Vallejo, M . Mol. Neurobiol. - 39 (2) : 90-9100 (PMID: 19238593) (doi:10.1007/s12035-009-8055-2)
1 Nov | 2008 Pituitary adenylate cyclase-activating polypeptide stimulates glial fibrillary acidic protein gene expression in cortical precursor cells by activating Ras and Rap1. Lastres-Becker, I , Fernández-Pérez, A , Cebolla, B , Vallejo, M . Mol. Cell. Neurosci. - 39 (3) : 291-301 (PMID: 18707003) (doi:10.1016/j.mcn.2008.07.009)
25 Jun | 2008 DREAM mediates cAMP-dependent, Ca2+-induced stimulation of GFAP gene expression and regulates cortical astrogliogenesis. Cebolla, B , Fernández-Pérez, A , Perea, G, Araque, A, Vallejo, M . J. Neurosci. - 28 (26) : 6703-6713 (PMID: 18579744) (doi:10.1523/JNEUROSCI.0215-08.2008)
1 Nov | 2006 The homeoprotein Alx3 expressed in pancreatic beta-cells regulates insulin gene transcription by interacting with the basic helix-loop-helix protein E47. Mirasierra, M , Vallejo, M . Mol. Endocrinol. - 20 (11) : 2876-2889 (PMID: 16825292) (doi:10.1210/me.2005-0472)
11 May | 2006 Nuclear factor-I regulates glial fibrillary acidic protein gene expression in astrocytes differentiated from cortical precursor cells. Cebolla, B , Vallejo, M . J. Neurochem. - 97 (4) : 1057-1070 (PMID: 16606365) (doi:10.1111/j.1471-4159.2006.03804.x)
3 Sep | 2004 The homeoprotein Alx3 contains discrete functional domains and exhibits cell-specific and selective monomeric binding and transactivation. Pérez-Villamil, B, Mirasierra, M , Vallejo, M . J. Biol. Chem. - 279 (36) : 38062-38071 (PMID: 15226305) (doi:10.1074/jbc.M400800200)
30 Dec | 2002 Pituitary adenylate cyclase-activating polypeptide induces astrocyte differentiation of precursor cells from developing cerebral cortex. Vallejo, I, Vallejo, M . Mol. Cell. Neurosci. - 21 (4) : 671-683 (PMID: 12504599)
12 Apr | 2001 Prevalence, phenotypic spectrum, and modes of inheritance of gonadotropin-releasing hormone receptor mutations in idiopathic hypogonadotropic hypogonadism. Beranova, M, Oliveira, LM, Bédécarrats, GY, Schipani, E, Vallejo, M , Ammini, AC, Quintos, JB, Hall, JE, Martin, KA, Hayes, FJ, Pitteloud, N, Kaiser, UB, Crowley, WF, Seminara, SB. J. Clin. Endocrinol. Metab. - 86 (4) : 1580-1588 (PMID: 11297587) (doi:10.1210/jcem.86.4.7395)
12 Apr | 2001 The importance of autosomal genes in Kallmann syndrome: genotype-phenotype correlations and neuroendocrine characteristics. Oliveira, LM, Seminara, SB, Beranova, M, Hayes, FJ, Valkenburgh, SB, Schipani, E, Costa, EM, Latronico, AC, Crowley, WF, Vallejo, M . J. Clin. Endocrinol. Metab. - 86 (4) : 1532-1538 (PMID: 11297579) (doi:10.1210/jcem.86.4.7420)
14 Mar | 2001 Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Zulewski, H, Abraham, EJ, Gerlach, MJ, Daniel, PB, Moritz, W, Müller, B, Vallejo, M , Thomas, MK, Habener, JF. Diabetes - 50 (3) : 521-533 (PMID: 11246871)
23 Jun | 2000 Pancreatic homeodomain transcription factor IDX1/IPF1 expressed in developing brain regulates somatostatin gene transcription in embryonic neural cells. Schwartz, PT, Perez-Villamil, B, Rivera, A, Moratalla, R, Vallejo, M . J. Biol. Chem. - 275 (25) : 19106-19114 (PMID: 10751390) (doi:10.1074/jbc.M000655200)
15 Oct | 1999 Astroglial differentiation of cortical precursor cells triggered by activation of the cAMP-dependent signaling pathway. McManus, MF, Chen, LC, Vallejo, I, Vallejo, M . J. Neurosci. - 19 (20) : 9004-9015 (PMID: 10516318)
17 Aug | 1999 The pancreatic homeodomain transcription factor IDX1/IPF1 is expressed in neural cells during brain development. Perez-Villamil, B, Schwartz, PT, Vallejo, M . Endocrinology - 140 (8) : 3857-3860 (PMID: 10433248) (doi:10.1210/endo.140.8.7048)
1 Sep | 1998 Differential regulation of basal and cyclic adenosine 3',5'-monophosphate-induced somatostatin gene transcription in neural cells by DNA control elements that bind homeodomain proteins. Schwartz, PT, Vallejo, M . Mol. Endocrinol. - 12 (9) : 1280-1293 (PMID: 9731698) (doi:10.1210/mend.12.9.0171)