2 Feb | 2024 β-cell Jagged1 is sufficient but not necessary for islet Notch activity and insulin secretory defects in obese mice. Suda, N, Bartolomé, A , Liang, J, Son, J, Yagishita, Y, Siebel, C, Accili, D, Ding, H, Pajvani, UB. Mol Metab (PMID: 38311286) (doi:10.1016/j.molmet.2024.101894)
8 Mar | 2023 The Pancreatic Beta Cell: Editorial. Bartolomé, A . Biomolecules - 13 (3) (PMID: 36979430) (doi:10.3390/biom13030495)
8 Feb | 2023 Notch-mediated hepatocyte MCP-1 secretion causes liver fibrosis. Kang, J, Postigo-Fernandez, J, Kim, K, Zhu, C, Yu, J, Meroni, M, Mayfield, B, Bartolomé, A , Dapito, DH, Ferrante, AW, Dongiovanni, P, Valenti, L, Creusot, RJ, Pajvani, UB. JCI Insight - 8 (3) (PMID: 36752206) (doi:10.1172/jci.insight.165369)
9 Aug | 2022 An Overfeeding-Induced Obesity Mouse Model Reveals Necessity for Sin3a in Postnatal Peak β Cell Mass Acquisition. Bartolomé, A , Ravusin, Y, Yu, J, Ferrante, AW, Pajvani, UB. Diabetes (PMID: 35944274) (doi:10.2337/db22-0306)
31 Mar | 2022 MafA Regulation in β-Cells: From Transcriptional to Post-Translational Mechanisms. Liang, J, Chirikjian, M, Pajvani, UB, Bartolomé, A . Biomolecules - 12 (4) (PMID: 35454124) (doi:10.3390/biom12040535)
22 Mar | 2022 Notch-mediated Ephrin signaling disrupts islet architecture and β cell function. Bartolomé, A , Suda, N, Yu, J, Zhu, C, Son, J, Ding, H, Califano, A, Accili, D, Pajvani, UB. JCI Insight - 7 (6) (PMID: 35167496) (doi:10.1172/jci.insight.157694)
2 Jan | 2022 Stem Cell-Derived β Cells: A Versatile Research Platform to Interrogate the Genetic Basis of β Cell Dysfunction. Bartolomé, A . Int J Mol Sci - 23 (1) (PMID: 35008927) (doi:10.3390/ijms23010501)
23 Jun | 2021 Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis. Yu, J, Zhu, C, Wang, X, Kim, K, Bartolome, A , Dongiovanni, P, Yates, KP, Valenti, L, Carrer, M, Sadowski, T, Qiang, L, Tabas, I, Lavine, JE, Pajvani, UB. Sci Transl Med - 13 (599) (PMID: 34162749) (doi:10.1126/scitranslmed.abe1692)
7 May | 2021 Angiotensin converting enzyme 2 is a novel target of the γ-secretase complex. Bartolomé, A , Liang, J, Wang, P, Ho, DD, Pajvani, UB. Sci Rep - 11 (1) : 9803 (PMID: 33963249) (doi:10.1038/s41598-021-89379-x)
8 Mar | 2021 MTOR and Beta Cell Adaptation in T2D. Bartolomé, A , Pajvani, UB. J Clin Endocrinol Metab - 106 (3) : e1466-e1467 (PMID: 33274365) (doi:10.1210/clinem/dgaa906)
1 Mar | 2021 Notch activity characterizes a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features. Zhu, C, Ho, YJ, Salomao, MA, Dapito, DH, Bartolome, A , Schwabe, RF, Lee, JS, Lowe, SW, Pajvani, UB. J Hepatol - 74 (3) : 613-626 (PMID: 33038431) (doi:10.1016/j.jhep.2020.09.032)
8 Feb | 2021 Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Klionsky, DJ, [ .., ], Bartolome, A , [ .., ], Cuadrado, A , [ .., ], Escalante, R , [ .., ], García-Sanz, P , [ .., ], Lastres-Becker, I , [ .., ], León, Y , [ .., ], Martin-Sanz, P , [ .., ], Pajares, M , [ .., ], Rojo, AI , [ .., ], Valverde, AM , [ .., ], Varela-Nieto, I , [ .., ], Villalobo, A , [ .., ], Vincent, O , [ .., ], Tong, CK. Autophagy (PMID: 33634751) (doi:10.1080/15548627.2020.1797280)
1 Sep | 2020 Angiotensin converting enzyme 2 is a novel target of the γ-secretase complex. Bartolomé, A , Liang, J, Wang, P, Ho, DD, Pajvani, UB. bioRxiv (PMID: 32908985) (doi:10.1101/2020.09.01.277954)
7 May | 2020 GCN2 regulates pancreatic β cell mass by sensing intracellular amino acid levels. Kanno, A, Asahara, SI, Furubayashi, A, Masuda, K, Yoshitomi, R, Suzuki, E, Takai, T, Kimura-Koyanagi, M, Matsuda, T, Bartolome, A , Hirota, Y, Yokoi, N, Inaba, Y, Inoue, H, Matsumoto, M, Inoue, K, Abe, T, Wei, FY, Tomizawa, K, Ogawa, W, Seino, S, Kasuga, M, Kido, Y. JCI Insight - 5 (9) (PMID: 32376799) (doi:10.1172/jci.insight.128820)
30 Sep | 2019 Essential role of glucokinase in the protection of pancreatic β cells to the glucose energetic status. Marqués, P, Kamitz, A, Bartolomé, A , Burillo, J, Martínez, H, Jiménez, B, Fernández-Rhodes, M, Guillén, C, Benito, M. Cell Death Discov - 5 : 138 (PMID: 31583121) (doi:10.1038/s41420-019-0219-x)
2 Jan | 2019 Notch signaling dynamically regulates adult β cell proliferation and maturity. Bartolome, A , Zhu, C, Sussel, L, Pajvani, UB. J Clin Invest - 129 (1) : 268-280 (PMID: 30375986) (doi:10.1172/JCI98098)
21 Nov | 2018 Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis. Zhu, C, Kim, K, Wang, X, Bartolome, A , Salomao, M, Dongiovanni, P, Meroni, M, Graham, MJ, Yates, KP, Diehl, AM, Schwabe, RF, Tabas, I, Valenti, L, Lavine, JE, Pajvani, UB. Sci Transl Med - 10 (468) (PMID: 30463916) (doi:10.1126/scitranslmed.aat0344)
7 Aug | 2018 Evidence for a Non-leptin System that Defends against Weight Gain in Overfeeding. Ravussin, Y, Edwin, E, Gallop, M, Xu, L, Bartolomé, A , Kraakman, MJ, LeDuc, CA, Ferrante, AW. Cell Metab - 28 (2) : 289-299.e5 (PMID: 29937378) (doi:10.1016/j.cmet.2018.05.029)
1 Dec | 2017 MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling. Bartolomé, A , García-Aguilar, A, Asahara, SI, Kido, Y, Guillén, C, Pajvani, UB, Benito, M. Mol Cell Biol - 37 (23) (PMID: 28894028) (doi:10.1128/MCB.00441-17)
8 Sep | 2017 Histone deacetylase regulates insulin signaling via two pathways in pancreatic β cells. Kawada, Y, Asahara, SI, Sugiura, Y, Sato, A, Furubayashi, A, Kawamura, M, Bartolome, A , Terashi-Suzuki, E, Takai, T, Kanno, A, Koyanagi-Kimura, M, Matsuda, T, Hashimoto, N, Kido, Y. PLoS One - 12 (9) : e0184435 (PMID: 28886131) (doi:10.1371/journal.pone.0184435)
1 Nov | 2016 TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy. García-Aguilar, A, Guillén, C, Nellist, M, Bartolomé, A , Benito, M. Biochim Biophys Acta - 1863 (11) : 2658-2667 (PMID: 27542907) (doi:10.1016/j.bbamcr.2016.08.006)
19 Oct | 2016 Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Klionsky, DJ, [ .., ], Bartolomé, A , [ .., ], Escalante, R , [ .., ], Magariños, M , [ .., ], Martín-Sanz, P , [ .., ], Sanchez-Prieto, R , [ .., ], Valverde, AM , [ .., ], Varela-Nieto, I , [ .., ], Zughaier, SM. Autophagy - 12 (1) : 1-222 (PMID: 26799652) (doi:10.1080/15548627.2015.1100356)
7 Jul | 2015 Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c. Asahara, S, Etoh, H, Inoue, H, Teruyama, K, Shibutani, Y, Ihara, Y, Kawada, Y, Bartolome, A , Hashimoto, N, Matsuda, T, Koyanagi-Kimura, M, Kanno, A, Hirota, Y, Hosooka, T, Nagashima, K, Nishimura, W, Inoue, H, Matsumoto, M, Higgins, MJ, Yasuda, K, Inagaki, N, Seino, S, Kasuga, M, Kido, Y. Proc Natl Acad Sci U S A - 112 (27) : 8332-8337 (PMID: 26100882) (doi:10.1073/pnas.1422104112)
19 Jun | 2015 Regulation of Pancreatic β Cell Mass by Cross-Interaction between CCAAT Enhancer Binding Protein β Induced by Endoplasmic Reticulum Stress and AMP-Activated Protein Kinase Activity. Matsuda, T, Takahashi, H, Mieda, Y, Shimizu, S, Kawamoto, T, Matsuura, Y, Takai, T, Suzuki, E, Kanno, A, Koyanagi-Kimura, M, Asahara, S, Bartolome, A , Yokoi, N, Inoue, H, Ogawa, W, Seino, S, Kido, Y. PLoS One - 10 (6) : e0130757 (PMID: 26091000) (doi:10.1371/journal.pone.0130757)
1 Sep | 2014 Pancreatic β-cell failure mediated by mTORC1 hyperactivity and autophagic impairment. Bartolomé, A , Kimura-Koyanagi, M, Asahara, S, Guillén, C, Inoue, H, Teruyama, K, Shimizu, S, Kanno, A, García-Aguilar, A, Koike, M, Uchiyama, Y, Benito, M, Noda, T, Kido, Y. Diabetes - 63 (9) : 2996-3008 (PMID: 24740570) (doi:10.2337/db13-0970)
1 Jan | 2014 Role of the mammalian target of rapamycin (mTOR) complexes in pancreatic β-cell mass regulation. Bartolome, A , Guillén, C. Vitam Horm - 95 : 425-469 (PMID: 24559928) (doi:10.1016/B978-0-12-800174-5.00017-X)
1 Nov | 2013 Autophagy impairment aggravates the inhibitory effects of high glucose on osteoblast viability and function. Bartolomé, A , López-Herradón, A, Portal-Núñez, S, García-Aguilar, A, Esbrit, P, Benito, M, Guillén, C. Biochem J - 455 (3) : 329-337 (PMID: 23981124) (doi:10.1042/BJ20130562)
1 Oct | 2013 Concerted expression of the thermogenic and bioenergetic mitochondrial protein machinery in brown adipose tissue. Guillen, C, Bartolome, A , Vila-Bedmar, R, García-Aguilar, A, Gomez-Hernandez, A, Benito, M. J Cell Biochem - 114 (10) : 2306-2313 (PMID: 23606415) (doi:10.1002/jcb.24577)
1 Dec | 2012 Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death. Bartolome, A , Guillen, C, Benito, M. Autophagy - 8 (12) : 1757-1768 (PMID: 22951927) (doi:10.4161/auto.21994)
1 Oct | 2012 DPP4 inhibitor vildagliptin preserves β-cell mass through amelioration of endoplasmic reticulum stress in C/EBPB transgenic mice. Shimizu, S, Hosooka, T, Matsuda, T, Asahara, S, Koyanagi-Kimura, M, Kanno, A, Bartolome, A , Etoh, H, Fuchita, M, Teruyama, K, Takahashi, H, Inoue, H, Mieda, Y, Hashimoto, N, Seino, S, Kido, Y. J Mol Endocrinol - 49 (2) : 125-135 (PMID: 22822047) (doi:10.1530/JME-12-0039)
5 Jul | 2010 Role of the TSC1-TSC2 complex in the integration of insulin and glucose signaling involved in pancreatic beta-cell proliferation. Bartolomé, A , Guillén, C, Benito, M. Endocrinology - 151 (7) : 3084-3094 (PMID: 20427478) (doi:10.1210/en.2010-0048)