3 Mar | 2025 Health position paper and redox perspectives - Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases. Cuadrado, A , Cazalla, E , Bach, A, Bathish, B, Naidu, SD, DeNicola, GM, Dinkova-Kostova, AT, Fernández-Ginés, R , Grochot-Przeczek, A, Hayes, JD, Kensler, TW, León, R, Liby, KT, López, MG, Manda, G, Shivakumar, AK, Hakomäki, H, Moerland, JA, Motohashi, H, Rojo, AI , Sykiotis, GP, Taguchi, K, Valverde, ÁM , Yamamoto, M, Levonen, AL. Redox Biol (PMID: 40059038) (doi:10.1016/j.redox.2025.103569)
19 Jan | 2025 Corrigendum to "Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases" [Redox Biol. 79 (2025) 103464]. Rojo, AI , Buttari, B, Cadenas, S, Carlos, AR, Cuadrado, A , Falcão, AS, López, MG, Georgiev, MI, Grochot-Przeczek, A, Gumeni, S, Jiménez-Villegas, J , Horbanczuk, JO, Konu, O, Lastres-Becker, I , Levonen, AL, Maksimova, V, Michaeloudes, C, Mihaylova, LV, Mickael, ME, Milisav, I, Miova, B, Rada, P , Santos, M, Seabra, MC, Strac, DS, Tenreiro, S, Trougakos, IP, Dinkova-Kostova, AT. Redox Biol (PMID: 39833011) (doi:10.1016/j.redox.2025.103496)
16 Jan | 2025 Network-Based Drug Optimization toward the Treatment of Parkinson's Disease: NRF2, MAO-B, Oxidative Stress, and Chronic Neuroinflammation. Duarte, P , Sanchez-Porro, FJ, Crisman, E, Cores, Á, Jiménez, I, Cuadrado, A , Menéndez, JC, León, R. J Med Chem (PMID: 39818855) (doi:10.1021/acs.jmedchem.4c02659)
16 Dec | 2024 Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases. Rojo, AI , Buttari, B, Cadenas, S, Carlos, AR, Cuadrado, A , Falcão, AS, López, MG, Georgiev, MI, Grochot-Przeczek, A, Gumeni, S, Jimenez-Villegas, J, Horbanczuk, JO, Konu, O, Lastres-Becker, I , Levonen, AL, Maksimova, V, Michaeloudes, C, Mihaylova, LV, Mickael, ME, Milisav, I, Miova, B, Rada, P , Santos, M, Seabra, MC, Strac, DS, Tenreiro, S, Trougakos, IP, Dinkova-Kostova, AT. Redox Biol - 79 : 103464 (PMID: 39709790) (doi:10.1016/j.redox.2024.103464)
27 Nov | 2024 NRF2 activation by 6-MSITC increases the generation of neuroprotective, soluble α amyloid precursor protein by inducing the metalloprotease gene ADAM17. Carnicero-Senabre, D , Jiménez-Villegas, J , Álvarez-Garrote, S, Escoll, M , Cuadrado, A , Rojo, AI . Free Radic Biol Med (PMID: 39613049) (doi:10.1016/j.freeradbiomed.2024.11.048)
21 Nov | 2024 Role of the transcription factor NRF2 in maintaining the integrity of the Blood-Brain Barrier. Cazalla, E , Cuadrado, A , García-Yagüe, ÁJ . Fluids Barriers CNS - 21 (1) : 93 (PMID: 39574123) (doi:10.1186/s12987-024-00599-5)
30 Mar | 2024 Biomarkers of NRF2 signalling: Current status and future challenges. Morgenstern, C, Lastres-Becker, I , Demirdöğen, BC, Costa, VM, Daiber, A, Foresti, R, Motterlini, R, Kalyoncu, S, Arioz, BI, Genc, S, Jakubowska, M, Trougakos, IP, Piechota-Polanczyk, A, Mickael, M, Santos, M, Kensler, TW, Cuadrado, A , Copple, IM. Redox Biol - 72 : 103134 (PMID: 38643749) (doi:10.1016/j.redox.2024.103134)
7 Mar | 2024 Inhibition of glycogen synthase kinase-3 enhances NRF2 protein stability, nuclear localisation and target gene transcription in pancreatic beta cells. Patibandla, C, van Aalten, L, Dinkova-Kostova, AT, Honda, T, Cuadrado, A , Fernández-Ginés, R , McNeilly, AD, Hayes, JD, Cantley, J, Sutherland, C. Redox Biol - 71 : 103117 (PMID: 38479223) (doi:10.1016/j.redox.2024.103117)
3 Jan | 2024 Specific targeting of the NRF2/β-TrCP axis promotes beneficial effects in NASH. Fernández-Ginés, R , Encinar, JA, Escoll, M , Carnicero-Senabre, D , Jiménez-Villegas, J , García-Yagüe, ÁJ , González-Rodríguez, Á , Garcia-Martinez, I , M Valverde, Á , Rojo, AI , Cuadrado, A . Redox Biol - 69 : 103027 (PMID: 38184999) (doi:10.1016/j.redox.2024.103027)
7 Sep | 2023 Drug repurposing on Alzheimer's disease through modulation of NRF2 neighborhood. Bourdakou, MM, Fernández-Ginés, R , Cuadrado, A , Spyrou, GM. Redox Biol - 67 : 102881 (PMID: 37696195) (doi:10.1016/j.redox.2023.102881)
7 Sep | 2023 Redox Regulation of Microglial Inflammatory Response: Fine Control of NLRP3 Inflammasome through Nrf2 and NOX4. Palomino-Antolín, A, Decouty-Pérez, C, Farré-Alins, V, Narros-Fernández, P, Lopez-Rodriguez, AB, Álvarez-Rubal, M, Valencia, I, López-Muñoz, F, Ramos, E, Cuadrado, A , Casas, AI, Romero, A, Egea, J. Antioxidants (Basel) - 12 (9) (PMID: 37760032) (doi:10.3390/antiox12091729)
31 Jul | 2023 Mechanisms of NURR1 Regulation: Consequences for Its Biological Activity and Involvement in Pathology. García-Yagüe, ÁJ , Cuadrado, A . Int J Mol Sci - 24 (15) (PMID: 37569656) (doi:10.3390/ijms241512280)
6 Jan | 2023 Personalized redox medicine in inflammatory bowel diseases: an emerging role for HIF-1α and NRF2 as therapeutic targets. Bourgonje, AR, Kloska, D, Grochot-Przęczek, A, Feelisch, M, Cuadrado, A , van Goor, H. Redox Biol - 60 : 102603 (PMID: 36634466) (doi:10.1016/j.redox.2023.102603)
28 Dec | 2022 Introduction to Special Issue on "Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases". Cuadrado, A , Dinkova-Kostova, AT, Mann, GE. Free Radic Biol Med (PMID: 36586454) (doi:10.1016/j.freeradbiomed.2022.12.100)
28 Sep | 2022 The current status and future prospects for therapeutic targeting of KEAP1-NRF2 and β-TrCP-NRF2 interactions in cancer chemoresistance. Srivastava, R, Fernández-Ginés, R , Encinar, JA, Cuadrado, A , Wells, G. Free Radic Biol Med (PMID: 36181972) (doi:10.1016/j.freeradbiomed.2022.09.023)
25 Sep | 2022 Dipeptide Repeat Pathology in C9orf72-ALS Is Associated with Redox, Mitochondrial and NRF2 Pathway Imbalance. Jiménez-Villegas, J , Kirby, J, Mata, A, Cadenas, S, Turner, MR, Malaspina, A, Shaw, PJ, Cuadrado, A , Rojo, AI . Antioxidants (Basel) - 11 (10) (PMID: 36290620) (doi:10.3390/antiox11101897)
12 Sep | 2022 Overlooked and valuable facts to know in the NRF2/KEAP1 field. Kopacz, A, Rojo, AI , Patibandla, C, Lastra-Martínez, D , Piechota-Polanczyk, A, Kloska, D, Jozkowicz, A, Sutherland, C, Cuadrado, A , Grochot-Przeczek, A. Free Radic Biol Med - 192 : 37-49 (PMID: 36100148) (doi:10.1016/j.freeradbiomed.2022.08.044)
10 Sep | 2022 KEAP1-NRF2 protein-protein interaction inhibitors: Design, pharmacological properties and therapeutic potential. Crisman, E, Duarte, P , Dauden, E, Cuadrado, A , Rodríguez-Franco, MI, López, MG, León, R. Med Res Rev (PMID: 36086898) (doi:10.1002/med.21925)
1 Sep | 2022 Corrigendum to "An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver" [Redox Biol. 55 (2022) 102396/PMID: 35839629]. Fernández-Ginés, R , Encinar, JA, Hayes, JD, Oliva, B, Rodríguez-Franco, MI, Rojo, AI , Cuadrado, A . Redox Biol - 55 : 102428 (PMID: 35931641) (doi:10.1016/j.redox.2022.102428)
11 Aug | 2022 Pros and cons of NRF2 activation as adjunctive therapy in rheumatoid arthritis. Manda, G, Milanesi, E, Genc, S, Niculite, CM, Neagoe, IV, Tastan, B, Dragnea, EM, Cuadrado, A . Free Radic Biol Med (PMID: 35964840) (doi:10.1016/j.freeradbiomed.2022.08.012)
19 Jul | 2022 Loss of KEAP1 Causes an Accumulation of Nondegradative Organelles. Uribe-Carretero, E, Martinez-Chacón, G, Yakhine-Diop, SMS, Duque-González, G, Rodríguez-Arribas, M, Alegre-Cortés, E, Paredes-Barquero, M, Canales-Cortés, S, Pizarro-Estrella, E, Cuadrado, A , González-Polo, RA, Fuentes, JM, Niso-Santano, M. Antioxidants (Basel) - 11 (7) (PMID: 35883891) (doi:10.3390/antiox11071398)
11 Jul | 2022 An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver. Fernández-Ginés, R , Encinar, JA, Hayes, JD, Oliva, B, Rodríguez-Franco, MI, Rojo, AI , Cuadrado, A . Redox Biol - 55 : 102396 (PMID: 35839629) (doi:10.1016/j.redox.2022.102396)
1 Jun | 2022 Specialized Proresolving Mediators Protect Against Experimental Autoimmune Myocarditis by Modulating Ca2+ Handling and NRF2 Activation. Val-Blasco, A, Prieto, P , Jaén, RI , Gil-Fernández, M , Pajares, M , Domenech, N, Terrón, V , Tamayo, M , Jorge, I, Vázquez, J, Bueno-Sen, A, Vallejo-Cremades, MT, Pombo-Otero, J, Sanchez-García, S , Ruiz-Hurtado, G, Gómez, AM, Zaragoza, C, Crespo-Leiro, MG, López-Collazo, E, Cuadrado, A , Delgado, C , Boscá, L , Fernández-Velasco, M . JACC Basic Transl Sci - 7 (6) : 544-560 (PMID: 35818504) (doi:10.1016/j.jacbts.2022.01.009)
22 May | 2022 Protective actions of nuclear factor erythroid 2-related factor 2 (NRF2) and downstream pathways against environmental stressors. Bayo Jimenez, MT, Frenis, K, Hahad, O, Steven, S, Cohen, G, Cuadrado, A , Münzel, T, Daiber, A. Free Radic Biol Med (PMID: 35613665) (doi:10.1016/j.freeradbiomed.2022.05.016)
21 May | 2022 Altered Blood and Brain Expression of Inflammation and Redox Genes in Alzheimer's Disease, Common to APPV717I × TAUP301L Mice and Patients. Cucos, CA, Milanesi, E, Dobre, M, Musat, IA, Manda, G, Cuadrado, A . Int J Mol Sci - 23 (10) (PMID: 35628609) (doi:10.3390/ijms23105799)
11 May | 2022 Transcription Factor NRF2 Participates in Cell Cycle Progression at the Level of G1/S and Mitotic Checkpoints. Lastra, D , Escoll, M , Cuadrado, A . Antioxidants (Basel) - 11 (5) (PMID: 35624810) (doi:10.3390/antiox11050946)
27 Jan | 2022 Novel Series of Dual NRF2 Inducers and Selective MAO-B Inhibitors for the Treatment of Parkinson's Disease. Duarte, P , Michalska, P, Crisman, E, Cuadrado, A , León, R. Antioxidants (Basel) - 11 (2) (PMID: 35204129) (doi:10.3390/antiox11020247)
20 Nov | 2021 Whole Blood Expression Pattern of Inflammation and Redox Genes in Mild Alzheimer's Disease. Milanesi, E, Dobre, M, Cucos, CA, Rojo, AI , Jiménez-Villegas, J , Capetillo-Zarate, E, Matute, C, Piñol-Ripoll, G, Manda, G, Cuadrado, A . J Inflamm Res - 14 : 6085-6102 (PMID: 34848989) (doi:10.2147/JIR.S334337)
12 Oct | 2021 Brain-Protective Mechanisms of Transcription Factor NRF2: Toward a Common Strategy for Neurodegenerative Diseases. Cuadrado, A . Annu Rev Pharmacol Toxicol (PMID: 34637322) (doi:10.1146/annurev-pharmtox-052220-103416)
5 Oct | 2021 α-Synuclein Induces the GSK-3-Mediated Phosphorylation and Degradation of NURR1 and Loss of Dopaminergic Hallmarks. García-Yagüe, ÁJ , Lastres-Becker, I , Stefanis, L, Vassilatis, DK, Cuadrado, A . Mol Neurobiol (PMID: 34609698) (doi:10.1007/s12035-021-02558-9)
29 Sep | 2021 Reduced Blood RGS2 Expression in Mild Cognitive Impairment Patients. Milanesi, E, Cucos, CA, Matias-Guiu, JA, Piñol-Ripoll, G, Manda, G, Dobre, M, Cuadrado, A . Front Aging Neurosci - 13 : 738244 (PMID: 34658840) (doi:10.3389/fnagi.2021.738244)
24 Jul | 2021 NRF2 as a therapeutic opportunity to impact in the molecular roadmap of ALS. Jiménez-Villegas, J , Ferraiuolo, L, Mead, RJ, Shaw, PJ, Cuadrado, A , Rojo, AI . Free Radic Biol Med - 173 : 125-141 (PMID: 34314817) (doi:10.1016/j.freeradbiomed.2021.07.022)
18 Feb | 2021 Distinctive Under-Expression Profile of Inflammatory and Redox Genes in the Blood of Elderly Patients with Cardiovascular Disease. Milanesi, E, Manda, G, Dobre, M, Codrici, E, Neagoe, IV, Popescu, BO, Bajenaru, OA, Spiru, L, Tudose, C, Prada, GI, Davidescu, EI, Piñol-Ripoll, G, Cuadrado, A . J Inflamm Res - 14 : 429-442 (PMID: 33658823) (doi:10.2147/JIR.S280328)
8 Feb | 2021 Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Klionsky, DJ, [ .., ], Bartolome, A , [ .., ], Cuadrado, A , [ .., ], Escalante, R , [ .., ], García-Sanz, P , [ .., ], Lastres-Becker, I , [ .., ], León, Y , [ .., ], Martin-Sanz, P , [ .., ], Pajares, M , [ .., ], Rojo, AI , [ .., ], Valverde, AM , [ .., ], Varela-Nieto, I , [ .., ], Villalobo, A , [ .., ], Vincent, O , [ .., ], Tong, CK. Autophagy (PMID: 33634751) (doi:10.1080/15548627.2020.1797280)
2 Oct | 2020 TAZ Represses the Neuronal Commitment of Neural Stem Cells. Robledinos-Antón, N , Escoll, M , Guan, KL, Cuadrado, A . Cells - 9 (10) (PMID: 33023162) (doi:10.3390/cells9102230)
1 Oct | 2020 On the Clinical Pharmacology of Reactive Oxygen Species. Casas, AI, Nogales, C, Mucke, HAM, Petraina, A, Cuadrado, A , Rojo, AI , Ghezzi, P, Jaquet, V, Augsburger, F, Dufrasne, F, Soubhye, J, Deshwal, S, Di Sante, M, Kaludercic, N, Di Lisa, F, Schmidt, HHHW. Pharmacol. Rev. - 72 (4) : 801-828 (PMID: 32859763) (doi:10.1124/pr.120.019422)
28 Aug | 2020 Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches. Duarte, P , Cuadrado, A , León, R. Handb Exp Pharmacol (PMID: 32852645) (doi:10.1007/164_2020_384)
20 Aug | 2020 Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology. Shi, L, Winchester, LM, Liu, BY, Killick, R, Ribe, EM, Westwood, S, Baird, AL, Buckley, NJ, Hong, S, Dobricic, V, Kilpert, F, Franke, A, Kiddle, S, Sattlecker, M, Dobson, R, Cuadrado, A , Hye, A, Ashton, NJ, Morgan, AR, Bos, I, Vos, SJB, Ten Kate, M, Scheltens, P, Vandenberghe, R, Gabel, S, Meersmans, K, Engelborghs, S, De Roeck, EE, Sleegers, K, Frisoni, GB, Blin, O, Richardson, JC, Bordet, R, Molinuevo, JL, Rami, L, Wallin, A, Kettunen, P, Tsolaki, M, Verhey, F, Lleó, A, Alcolea, D, Popp, J, Peyratout, G, Martinez-Lage, P, Tainta, M, Johannsen, P, Teunissen, CE, Freund-Levi, Y, Frölich, L, Legido-Quigley, C, Barkhof, F, Blennow, K, Rasmussen, KL, Nordestgaard, BG, Frikke-Schmidt, R, Nielsen, SF, Soininen, H, Vellas, B, Kloszewska, I, Mecocci, P, Zetterberg, H, Morgan, BP, Streffer, J, Visser, PJ, Bertram, L, Nevado-Holgado, AJ, Lovestone, S. J. Alzheimers Dis. (PMID: 32831200) (doi:10.3233/JAD-200208)
20 Aug | 2020 WIP Modulates Oxidative Stress through NRF2/KEAP1 in Glioblastoma Cells. Escoll, M , Lastra, D , Robledinos-Antón, N , Wandosell, F, Antón, IM, Cuadrado, A . Antioxidants (Basel) - 9 (9) (PMID: 32825452) (doi:10.3390/antiox9090773)
11 Aug | 2020 Perspectives on the Clinical Development of NRF2-Targeting Drugs. Lastra, D , Fernández-Ginés, R , Manda, G, Cuadrado, A . Handb Exp Pharmacol (PMID: 32776282) (doi:10.1007/164_2020_381)
14 Jul | 2020 Can Activation of NRF2 Be a Strategy against COVID-19? Cuadrado, A , Pajares, M , Benito, C , Jiménez-Villegas, J , Escoll, M , Fernández-Ginés, R , Garcia Yagüe, AJ , Lastra, D , Manda, G, Rojo, AI , Dinkova-Kostova, AT. Trends Pharmacol. Sci. (PMID: 32711925) (doi:10.1016/j.tips.2020.07.003)
14 Jul | 2020 Inflammation in Parkinson's Disease: Mechanisms and Therapeutic Implications. Pajares, M , I Rojo, A , Manda, G, Boscá, L , Cuadrado, A . Cells - 9 (7) (PMID: 32674367) (doi:10.3390/cells9071687)
2 Jun | 2020 NRF2 and Primary Cilia: An Emerging Partnership. Martin-Hurtado, A , Lastres-Becker, I , Cuadrado, A , Garcia-Gonzalo, FR . Antioxidants (Basel) - 9 (6) (PMID: 32498260) (doi:10.3390/antiox9060475)
28 Feb | 2020 Nordihydroguaiaretic Acid: From Herbal Medicine to Clinical Development for Cancer and Chronic Diseases. Manda, G, Rojo, AI , Martínez-Klimova, E, Pedraza-Chaverri, J, Cuadrado, A . Front Pharmacol - 11 : 151 (PMID: 32184727) (doi:10.3389/fphar.2020.00151)
25 Jan | 2020 Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties. Herrera-Arozamena, C, Estrada-Valencia, M, Pérez, C , Lagartera, L, Morales-García, JA , Pérez-Castillo, A , Franco-Gonzalez, JF, Michalska, P, Duarte, P , León, R, López, MG, Mills, A, Gago, F, García-Yagüe, ÁJ , Fernández-Ginés, R , Cuadrado, A , Rodríguez-Franco, MI. Eur J Med Chem - 190 : 112090 (PMID: 32018096) (doi:10.1016/j.ejmech.2020.112090)
2 Jan | 2020 Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomas. Escoll, M , Lastra, D , Pajares, M , Robledinos-Antón, N , Rojo, AI , Fernández-Ginés, R , Mendiola, M , Martínez-Marín, V, Esteban, I, López-Larrubia, P , Gargini, R, Cuadrado, A . Redox Biol - 30 : 101425 (PMID: 31918259) (doi:10.1016/j.redox.2019.101425)
12 Dec | 2019 Melatonin-sulforaphane hybrid ITH12674 attenuates glial response in vivo by blocking LPS binding to MD2 and receptor oligomerization. Michalska, P, Buendia, I, Duarte, P , FernandezMendivil, C, Negredo, P, Cuadrado, A , López, MG, Leon, R. Pharmacol. Res. (PMID: 31838078) (doi:10.1016/j.phrs.2019.104597)
25 Sep | 2019 NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling. Martin-Hurtado, A , Martin-Morales, R , Robledinos-Antón, N , Blanco, R , Palacios-Blanco, I , Lastres-Becker, I , Cuadrado, A , Garcia-Gonzalo, FR . Sci Rep - 9 (1) : 13896 (PMID: 31554934) (doi:10.1038/s41598-019-50356-0)
14 Jul | 2019 Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development. Robledinos-Antón, N , Fernández-Ginés, R , Manda, G, Cuadrado, A . Oxid Med Cell Longev - 2019 : 9372182 (PMID: 31396308) (doi:10.1155/2019/9372182)
1 Apr | 2019 Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases. Cuadrado, A , Rojo, AI , Wells, G, Hayes, JD, Cousin, SP, Rumsey, WL, Attucks, OC, Franklin, S, Levonen, AL, Kensler, TW, Dinkova-Kostova, AT. Nat Rev Drug Discov - 18 (4) : 295-317 (PMID: 30610225) (doi:10.1038/s41573-018-0008-x)
1 Sep | 2018 Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy. Rojo, AI , Pajares, M , García-Yagüe, AJ , Buendia, I, Van Leuven, F, Yamamoto, M, López, MG, Cuadrado, A . Redox Biol - 18 : 173-180 (PMID: 30029164) (doi:10.1016/j.redox.2018.07.006)
26 Jul | 2018 Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A. Pajares, M , Rojo, AI , Arias, E, Díaz-Carretero, A, Cuervo, AM, Cuadrado, A . Autophagy - 14 (8) : 1310-1322 (PMID: 29950142) (doi:10.1080/15548627.2018.1474992)
1 Apr | 2018 Emerging Therapeutic Targets in Oncologic Photodynamic Therapy. Manda, G, Hinescu, ME, Neagoe, IV, Ferreira, LFV, Boscencu, R, Vasos, P, Basaga, SH, Cuadrado, A . Curr. Pharm. Des. - 24 (44) : 5268-5295 (PMID: 30674246) (doi:10.2174/1381612825666190122163832)
1 Apr | 2018 Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach. Cuadrado, A , Manda, G, Hassan, A, Alcaraz, MJ, Barbas, C, Daiber, A, Ghezzi, P, León, R, López, MG, Oliva, B, Pajares, M , Rojo, AI , Robledinos-Antón, N , Valverde, AM , Guney, E, Schmidt, HHHW. Pharmacol. Rev. - 70 (2) : 348-383 (PMID: 29507103) (doi:10.1124/pr.117.014753)
26 Feb | 2018 The Role of Free Radicals in Autophagy Regulation: Implications for Ageing. Pajares, M , Cuadrado, A , Engedal, N, Jirsova, Z, Cahova, M. Oxid Med Cell Longev - 2018 : 2450748 (PMID: 29682156) (doi:10.1155/2018/2450748)
6 Nov | 2017 Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy. Cuadrado, A , Kügler, S, Lastres-Becker, I . Redox Biol - 14 : 522-534 (PMID: 29121589) (doi:10.1016/j.redox.2017.10.010)
26 Oct | 2017 Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162]. Egea, J, Fabregat, I, Frapart, YM, Ghezzi, P, Görlach, A, Kietzmann, T, Kubaichuk, K, Knaus, UG, Lopez, MG, Olaso-Gonzalez, G, Petry, A, Schulz, R, Vina, J, Winyard, P, Abbas, K, Ademowo, OS, Afonso, CB, Andreadou, I, Antelmann, H, Antunes, F, Aslan, M, Bachschmid, MM, Barbosa, RM, Belousov, V, Berndt, C, Bernlohr, D, Bertrán, E, Bindoli, A, Bottari, SP, Brito, PM, Carrara, G, Casas, AI, Chatzi, A, Chondrogianni, N, Conrad, M, Cooke, MS, Costa, JG, Cuadrado, A , My-Chan Dang, P, De Smet, B, Debelec-Butuner, B, Dias, IHK, Dunn, JD, Edson, AJ, El Assar, M, El-Benna, J, Ferdinandy, P, Fernandes, AS, Fladmark, KE, Förstermann, U, Giniatullin, R, Giricz, Z, Görbe, A, Griffiths, H, Hampl, V, Hanf, A, Herget, J, Hernansanz-Agustín, P, Hillion, M, Huang, J, Ilikay, S, Jansen-Dürr, P, Jaquet, V, Joles, JA, Kalyanaraman, B, Kaminskyy, D, Karbaschi, M, Kleanthous, M, Klotz, LO, Korac, B, Korkmaz, KS, Koziel, R, Kračun, D, Krause, KH, Křen, V, Krieg, T, Laranjinha, J, Lazou, A, Li, H, Martínez-Ruiz, A, Matsui, R, McBean, GJ, Meredith, SP, Messens, J, Miguel, V, Mikhed, Y, Milisav, I, Milković, L, Miranda-Vizuete, A, Mojović, M, Monsalve, M , Mouthuy, PA, Mulvey, J, Münzel, T, Muzykantov, V, Nguyen, ITN, Oelze, M, Oliveira, NG, Palmeira, CM, Papaevgeniou, N, Pavićević, A, Pedre, B, Peyrot, F, Phylactides, M, Pircalabioru, GG, Pitt, AR, Poulsen, HE, Prieto, I, Rigobello, MP, Robledinos-Antón, N, Rodríguez-Mañas, L, Rolo, AP, Rousset, F, Ruskovska, T, Saraiva, N, Sasson, S, Schröder, K, Semen, K, Seredenina, T, Shakirzyanova, A, Smith, GL, Soldati, T, Sousa, BC, Spickett, CM, Stancic, A, Stasia, MJ, Steinbrenner, H, Stepanić, V, Steven, S, Tokatlidis, K, Tuncay, E, Turan, B, Ursini, F, Vacek, J, Vajnerova, O, Valentová, K, Van Breusegem, F, Varisli, L, Veal, EA, Yalçın, AS, Yelisyeyeva, O, Žarković, N, Zatloukalová, M, Zielonka, J, Touyz, RM, Papapetropoulos, A, Grune, T, Lamas, S, Schmidt, HHHW, Di Lisa, F, Daiber, A. Redox Biol (PMID: 29107648) (doi:10.1016/j.redox.2017.10.001)
19 Oct | 2017 Amyloid beta synaptotoxicity is Wnt-planar cell polarity dependent and blocked by fasudil. Sellers, KJ, Elliott, C, Jackson, J, Ghosh, A, Ribe, E, Rojo-Sanchís, A , Jarosz-Griffiths, HH, Watson, IA, Xia, W, Semenov, M, Morin, P, Hooper, NM, Porter, R, Preston, J, Al-Shawi, R, Baillie, G, Lovestone, S, Cuadrado, A , Harte, M, Simons, P, Srivastava, DP, Killick, R. Alzheimers Dement (PMID: 29055813) (doi:10.1016/j.jalz.2017.09.008)
1 Oct | 2017 NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology. Rojo, AI , Pajares, M , Rada, P , Nuñez, A, Nevado-Holgado, AJ, Killik, R, Van Leuven, F, Ribe, E, Lovestone, S, Yamamoto, M, Cuadrado, A . Redox Biol - 13 : 444-451 (PMID: 28704727) (doi:10.1016/j.redox.2017.07.006)
1 Oct | 2017 Transcription factor NRF2 controls the fate of neural stem cells in the subgranular zone of the hippocampus. Robledinos-Antón, N , Rojo, AI , Ferreiro, E, Núñez, Á, Krause, KH, Jaquet, V, Cuadrado, A . Redox Biol - 13 : 393-401 (PMID: 28667908) (doi:10.1016/j.redox.2017.06.010)
1 Sep | 2017 Retraction notice to "RETRACTED: 6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors" [Toxicology (2013) 109 - 119]. Tobón-Velasco, JC, Limón-Pacheco, JH, Orozco-Ibarra, M, Macías-Silva, M, Vázquez-Victorio, G, Cuevas, E, Ali, SF, Cuadrado, A , Pedraza-Chaverrí, J, Santamaría, A. Toxicology - 390 : 167 (PMID: 28991642) (doi:10.1016/j.tox.2017.10.001)
22 Jun | 2017 Mutant p53 oncogenic functions in cancer stem cells are regulated by WIP through YAP/TAZ. Escoll, M, Gargini, R, Cuadrado, A , Anton, IM, Wandosell, F. Oncogene - 36 (25) : 3515-3527 (PMID: 28166194) (doi:10.1038/onc.2016.518)
15 Jun | 2017 Oxidative Stress and Inflammation Induced by Environmental and Psychological Stressors: A Biomarker Perspective. Ghezzi, P, Floridi, L, Boraschi, D, Cuadrado, A , Manda, G, Levic, S, D'Acquisto, F, Hamilton, A, Athersuch, TJ, Selley, L. Antioxid. Redox Signal. (PMID: 28494612) (doi:10.1089/ars.2017.7147)
18 May | 2017 European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Egea, J, Fabregat, I, Frapart, YM, Ghezzi, P, Görlach, A, Kietzmann, T, Kubaichuk, K, Knaus, UG, Lopez, MG, Olaso-Gonzalez, G, Petry, A, Schulz, R, Vina, J, Winyard, P, Abbas, K, Ademowo, OS, Afonso, CB, Andreadou, I, Antelmann, H, Antunes, F, Aslan, M, Bachschmid, MM, Barbosa, RM, Belousov, V, Berndt, C, Bernlohr, D, Bertrán, E, Bindoli, A, Bottari, SP, Brito, PM, Carrara, G, Casas, AI, Chatzi, A, Chondrogianni, N, Conrad, M, Cooke, MS, Costa, JG, Cuadrado, A , My-Chan Dang, P, De Smet, B, Debelec-Butuner, B, Dias, IHK, Dunn, JD, Edson, AJ, El Assar, M, El-Benna, J, Ferdinandy, P, Fernandes, AS, Fladmark, KE, Förstermann, U, Giniatullin, R, Giricz, Z, Görbe, A, Griffiths, H, Hampl, V, Hanf, A, Herget, J, Hernansanz-Agustín, P , Hillion, M, Huang, J, Ilikay, S, Jansen-Dürr, P, Jaquet, V, Joles, JA, Kalyanaraman, B, Kaminskyy, D, Karbaschi, M, Kleanthous, M, Klotz, LO, Korac, B, Korkmaz, KS, Koziel, R, Kračun, D, Krause, KH, Křen, V, Krieg, T, Laranjinha, J, Lazou, A, Li, H, Martínez-Ruiz, A, Matsui, R, McBean, GJ, Meredith, SP, Messens, J, Miguel, V, Mikhed, Y, Milisav, I, Milković, L, Miranda-Vizuete, A, Mojović, M, Monsalve, M , Mouthuy, PA, Mulvey, J, Münzel, T, Muzykantov, V, Nguyen, ITN, Oelze, M, Oliveira, NG, Palmeira, CM, Papaevgeniou, N, Pavićević, A, Pedre, B, Peyrot, F, Phylactides, M, Pircalabioru, GG, Pitt, AR, Poulsen, HE, Prieto, I , Rigobello, MP, Robledinos-Antón, N , Rodríguez-Mañas, L, Rolo, AP, Rousset, F, Ruskovska, T, Saraiva, N, Sasson, S, Schröder, K, Semen, K, Seredenina, T, Shakirzyanova, A, Smith, GL, Soldati, T, Sousa, BC, Spickett, CM, Stancic, A, Stasia, MJ, Steinbrenner, H, Stepanić, V, Steven, S, Tokatlidis, K, Tuncay, E, Turan, B, Ursini, F, Vacek, J, Vajnerova, O, Valentová, K, Van Breusegem, F, Varisli, L, Veal, EA, Yalçın, AS, Yelisyeyeva, O, Žarković, N, Zatloukalová, M, Zielonka, J, Touyz, RM, Papapetropoulos, A, Grune, T, Lamas, S, Schmidt, HHHW, Di Lisa, F, Daiber, A. Redox Biol - 13 : 94-9162 (PMID: 28577489) (doi:10.1016/j.redox.2017.05.007)
24 Apr | 2017 Decreased neural precursor cell pool in NADPH oxidase 2-deficiency: From mouse brain to neural differentiation of patient derived iPSC. Nayernia, Z, Colaianna, M, Robledinos-Antón, N , Gutzwiller, E, Sloan-Béna, F, Stathaki, E, Hibaoui, Y, Cuadrado, A , Hescheler, J, José Stasia, M, Saric, T, Jaquet, V, Krause, KH. Redox Biol - 13 : 82-93 (PMID: 28575744) (doi:10.1016/j.redox.2017.04.026)
31 Mar | 2017 Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's disease. Gameiro, I, Michalska, P, Tenti, G, Cores, Á, Buendia, I, Rojo, AI , Georgakopoulos, ND, Hernández-Guijo, JM, Teresa Ramos, M, Wells, G, López, MG, Cuadrado, A , Menéndez, JC, León, R. Sci Rep - 7 : 45701 (PMID: 28361919) (doi:10.1038/srep45701)
1 Mar | 2017 Retraction notice toS-Allyl cysteine protects against 6-hydroxydopamine-induced neurotoxicity in the rat striatum: involvement of Nrf2 transcription factor activation and modulation of signaling kinase cascades [FRB 53/5 (2012) 1024 - 1040]. Tobón-Velasco, JC, Vázquez-Victorio, G, Macías-Silva, M, Cuevas, E, Ali, SF, Maldonado, PD, González-Trujano, ME, Cuadrado, A , José Pedraza-Chaverrí, , Santamaría, A. Free Radic. Biol. Med. - 104 : 382 (PMID: 28237391) (doi:10.1016/j.freeradbiomed.2016.12.044)
10 Jan | 2017 Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases. Pajares, M , Cuadrado, A , Rojo, AI . Redox Biol - 11 : 543-553 (PMID: 28104575) (doi:10.1016/j.redox.2017.01.006)
2 Oct | 2016 Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes. Pajares, M , Jiménez-Moreno, N, García-Yagüe, ÁJ , Escoll, M , de Ceballos, ML, Van Leuven, F, Rábano, A, Yamamoto, M, Rojo, AI , Cuadrado, A . Autophagy - 12 (10) : 1902-1916 (PMID: 27427974) (doi:10.1080/15548627.2016.1208889)
23 Aug | 2016 Heme-oxygenase I and PCG-1α regulate mitochondrial biogenesis via microglial activation of alpha7 nicotinic acetylcholine receptors using PNU282987. Navarro, E, Gonzalez-Lafuente, L, Perez-Liebana, I, Buendia, I, López-Bernardo, E, Sanchez-Ramos, C , Prieto, I , Cuadrado, A , Satrustegui, J, Cadenas, S, Monsalve, M , Lopez, MG. Antioxid. Redox Signal. (PMID: 27554853) (doi:10.1089/ars.2016.6698)
10 Jul | 2016 Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease. Lastres-Becker, I , García-Yagüe, AJ , Scannevin, RH, Casarejos, MJ, Kügler, S, Rábano, A, Cuadrado, A . Antioxid. Redox Signal. - 25 (2) : 61-77 (PMID: 27009601) (doi:10.1089/ars.2015.6549)
1 Jul | 2016 Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice. Freitas, AE, Egea, J, Buendia, I, Gómez-Rangel, V, Parada, E, Navarro, E, Casas, AI, Wojnicz, A, Ortiz, JA, Cuadrado, A , Ruiz-Nuño, A, Rodrigues, ALS, Lopez, MG. Mol. Neurobiol. - 53 (5) : 3030-3045 (PMID: 25966970) (doi:10.1007/s12035-015-9182-6)
20 Mar | 2016 Response to I. Batinic-Haberle et al. Schmidt, HH, Stocker, R, Paulsen, G, Ghezzi, P, Riley, D, Daiber, A, Cuadrado, A . Antioxid. Redox Signal. - 24 (9) : 525-526 (PMID: 27003744) (doi:10.1089/ars.2016.29029.hhs)
1 Dec | 2015 Redox control of protein degradation. Pajares, M , Jiménez-Moreno, N, Dias, IH, Debelec, B, Vucetic, M, Fladmark, KE, Basaga, H, Ribaric, S, Milisav, I, Cuadrado, A . Redox Biol - 6 : 409-420 (PMID: 26381917) (doi:10.1016/j.redox.2015.07.003)
10 Nov | 2015 Antioxidants in Translational Medicine. Schmidt, HH, Stocker, R, Vollbracht, C, Paulsen, G, Riley, D, Daiber, A, Cuadrado, A . Antioxid. Redox Signal. - 23 (14) : 1130-1143 (PMID: 26154592) (doi:10.1089/ars.2015.6393)
10 Nov | 2015 Clinical Relevance of Biomarkers of Oxidative Stress. Frijhoff, J, Winyard, PG, Zarkovic, N, Davies, SS, Stocker, R, Cheng, D, Knight, AR, Taylor, EL, Oettrich, J, Ruskovska, T, Gasparovic, AC, Cuadrado, A , Weber, D, Poulsen, HE, Grune, T, Schmidt, HH, Ghezzi, P. Antioxid. Redox Signal. - 23 (14) : 1144-1170 (PMID: 26415143) (doi:10.1089/ars.2015.6317)
10 Nov | 2015 Pharmacology and Clinical Drug Candidates in Redox Medicine. Dao, VT, Casas, AI, Maghzal, GJ, Seredenina, T, Kaludercic, N, Robledinos-Anton, N , Di Lisa, F, Stocker, R, Ghezzi, P, Jaquet, V, Cuadrado, A , Schmidt, HH. Antioxid. Redox Signal. - 23 (14) : 1113-1129 (PMID: 26415051) (doi:10.1089/ars.2015.6430)
10 Nov | 2015 Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications. Casas, AI, Dao, VT, Daiber, A, Maghzal, GJ, Di Lisa, F, Kaludercic, N, Leach, S, Cuadrado, A , Jaquet, V, Seredenina, T, Krause, KH, López, MG, Stocker, R, Ghezzi, P, Schmidt, HH. Antioxid. Redox Signal. - 23 (14) : 1171-1185 (PMID: 26583264) (doi:10.1089/ars.2015.6433)
28 Oct | 2015 Activation of autophagy in macrophages by pro-resolving lipid mediators. Prieto, P , Rosales-Mendoza, CE, Terrón, V , Toledano, V, Cuadrado, A , López-Collazo, E, Bannenberg, G, Martín-Sanz, P , Fernández-Velasco, M , Boscá, L . Autophagy - 11 (10) : 1729-1744 (PMID: 26506892) (doi:10.1080/15548627.2015.1078958)
4 Aug | 2015 Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1-independent manner. González-Rodríguez, Á , Santamaría, B , Mas-Gutierrez, JA, Rada, P , Fernández-Millán, E, Pardo, V , Álvarez, C, Cuadrado, A , Ros, M, Serrano, M, Valverde, ÁM . Mol Nutr Food Res - 59 (8) : 1431-1442 (PMID: 25808216) (doi:10.1002/mnfr.201400933)
1 Jul | 2015 Essential role of Nrf2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes. Valdecantos, MP , Prieto-Hontoria, PL, Pardo, V , Módol, T, Santamaría, B , Weber, M, Herrero, L, Serra, D, Muntané, J, Cuadrado, A , Moreno-Aliaga, MJ, Alfredo Martínez, J, Valverde, ÁM . Free Radic. Biol. Med. - 84 : 263-278 (PMID: 25841776) (doi:10.1016/j.freeradbiomed.2015.03.019)
1 Jul | 2015 Nrf2 protects the lung against inflammation induced by titanium dioxide nanoparticles: A positive regulator role of Nrf2 on cytokine release. Delgado-Buenrostro, NL, Medina-Reyes, EI, Lastres-Becker, I , Freyre-Fonseca, V, Ji, Z, Hernández-Pando, R, Marquina, B, Pedraza-Chaverri, J, Espada, S , Cuadrado, A , Chirino, YI. Environ. Toxicol. - 30 (7) : 782-792 (PMID: 24615891) (doi:10.1002/tox.21957)
12 Jun | 2015 Transcription Factor Nrf2: a novel target to modulate inflammatory and neuroprotective responses in Parkinson's disease. Cuadrado, A . Springerplus - 4 (Suppl 1) : L43 (PMID: 27386205) (doi:10.1186/2193-1801-4-S1-L43)
30 Apr | 2015 Structural and functional characterization of NRF2 degradation by glycogen synthase kinase 3/β-TrCP. Cuadrado, A . Free Radic. Biol. Med. (PMID: 25937177) (doi:10.1016/j.freeradbiomed.2015.04.029)
1 Mar | 2015 WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes. Rada, P , Rojo, AI , Offergeld, A, Feng, GJ, Velasco-Martín, JP, González-Sancho, JM , Valverde, ÁM , Dale, T, Regadera, J, Cuadrado, A . Antioxid. Redox Signal. - 22 (7) : 555-571 (PMID: 25336178) (doi:10.1089/ars.2014.6040)
20 Dec | 2014 The PTEN/NRF2 axis promotes human carcinogenesis. Rojo, AI , Rada, P , Mendiola, M , Ortega-Molina, A, Wojdyla, K, Rogowska-Wrzesinska, A, Hardisson, D, Serrano, M, Cuadrado, A . Antioxid. Redox Signal. - 21 (18) : 2498-2514 (PMID: 24892215) (doi:10.1089/ars.2014.5843)
7 Jul | 2014 Effects of Nrf2 deficiency on bone microarchitecture in an experimental model of osteoporosis. Ibáñez, L, Ferrándiz, ML, Brines, R, Guede, D, Cuadrado, A , Alcaraz, MJ. Oxid Med Cell Longev - 2014 : 726590 (PMID: 25120886) (doi:10.1155/2014/726590)
30 May | 2014 Transcription factors NRF2 and NF-κB are coordinated effectors of the Rho family, GTP-binding protein RAC1 during inflammation. Cuadrado, A , Martín-Moldes, Z, Ye, J, Lastres-Becker, I . J. Biol. Chem. - 289 (22) : 15244-15258 (PMID: 24759106) (doi:10.1074/jbc.M113.540633)
15 Jan | 2014 Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis. Lastres-Becker, I , Innamorato, NG , Jaworski, T, Rábano, A, Kügler, S, Van Leuven, F, Cuadrado, A . Brain - 137 (Pt 1) : 78-91 (PMID: 24277722) (doi:10.1093/brain/awt323)
1 Oct | 2013 Nrf2 participates in depressive disorders through an anti-inflammatory mechanism. Martín-de-Saavedra, MD, Budni, J, Cunha, MP, Gómez-Rangel, V, Lorrio, S, Del Barrio, L, Lastres-Becker, I , Parada, E, Tordera, RM, Rodrigues, AL, Cuadrado, A , López, MG. Psychoneuroendocrinology - 38 (10) : 2010-2022 (PMID: 23623252) (doi:10.1016/j.psyneuen.2013.03.020)
9 May | 2013 Protein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity. Mobasher, MA, González-Rodriguez, A, Santamaría, B, Ramos, S, Martín, MÁ, Goya, L, Rada, P, Letzig, L, James, LP, Cuadrado, A , Martín-Pérez, J , Simpson, KJ, Muntané, J, Valverde, AM . Cell Death Dis - 4 : e626 (PMID: 23661004) (doi:10.1038/cddis.2013.150)
22 Feb | 2013 Nuclear import and export signals control the subcellular localization of Nurr1 protein in response to oxidative stress. García-Yagüe, ÁJ , Rada, P , Rojo, AI , Lastres-Becker, I , Cuadrado, A . J. Biol. Chem. - 288 (8) : 5506-5517 (PMID: 23283970) (doi:10.1074/jbc.M112.439190)
1 Sep | 2012 S-allyl cysteine protects against 6-hydroxydopamine-induced neurotoxicity in the rat striatum: involvement of Nrf2 transcription factor activation and modulation of signaling kinase cascades. Tobón-Velasco, JC, Vázquez-Victorio, G, Macías-Silva, M, Cuevas, E, Ali, SF, Maldonado, PD, González-Trujano, ME, Cuadrado, A , Pedraza-Chaverrí, J, Santamaría, A. Free Radic. Biol. Med. - 53 (5) : 1024-1040 (PMID: 22781654) (doi:10.1016/j.freeradbiomed.2012.06.040)
1 Sep | 2012 Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis. Rada, P , Rojo, AI , Evrard-Todeschi, N, Innamorato, NG , Cotte, A, Jaworski, T, Tobón-Velasco, JC, Devijver, H, García-Mayoral, MF, Van Leuven, F, Hayes, JD, Bertho, G, Cuadrado, A . Mol. Cell. Biol. - 32 (17) : 3486-3499 (PMID: 22751928) (doi:10.1128/MCB.00180-12)
15 Jul | 2012 α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease. Lastres-Becker, I , Ulusoy, A, Innamorato, NG , Sahin, G, Rábano, A, Kirik, D, Cuadrado, A . Hum. Mol. Genet. - 21 (14) : 3173-3192 (PMID: 22513881) (doi:10.1093/hmg/dds143)
16 Jan | 2012 Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice. Martín-Moreno, AM, Brera, B, Spuch, C, Carro, E, García-García, L, Delgado, M, Pozo, MA, Innamorato, NG , Cuadrado, A , de Ceballos, ML. J Neuroinflammation - 9 : 8 (PMID: 22248049) (doi:10.1186/1742-2094-9-8)
15 Jan | 2012 Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3. Rojo, AI , Medina-Campos, ON, Rada, P , Zúñiga-Toalá, A, López-Gazcón, A, Espada, S , Pedraza-Chaverri, J, Cuadrado, A . Free Radic. Biol. Med. - 52 (2) : 473-487 (PMID: 22142471) (doi:10.1016/j.freeradbiomed.2011.11.003)
1 Dec | 2011 Nrf2 deficiency potentiates methamphetamine-induced dopaminergic axonal damage and gliosis in the striatum. Granado, N, Lastres-Becker, I , Ares-Santos, S, Oliva, I, Martin, E, Cuadrado, A , Moratalla, R. Glia - 59 (12) : 1850-1863 (PMID: 21882243) (doi:10.1002/glia.21229)
15 Aug | 2011 Deficiency of Nrf2 accelerates the effector phase of arthritis and aggravates joint disease. Maicas, N, Ferrándiz, ML, Brines, R, Ibáñez, L, Cuadrado, A , Koenders, MI, van den Berg, WB, Alcaraz, MJ. Antioxid. Redox Signal. - 15 (4) : 889-901 (PMID: 21406003) (doi:10.1089/ars.2010.3835)
15 Jun | 2011 Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism. Jazwa, A , Rojo, AI , Innamorato, NG , Hesse, M, Fernández-Ruiz, J, Cuadrado, A . Antioxid. Redox Signal. - 14 (12) : 2347-2360 (PMID: 21254817) (doi:10.1089/ars.2010.3731)
1 Jun | 2011 Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer's disease. Martín-Moreno, AM, Reigada, D, Ramírez, BG, Mechoulam, R, Innamorato, N , Cuadrado, A , de Ceballos, ML. Mol. Pharmacol. - 79 (6) : 964-973 (PMID: 21350020) (doi:10.1124/mol.111.071290)
1 Mar | 2011 SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner. Rada, P , Rojo, AI , Chowdhry, S, McMahon, M, Hayes, JD, Cuadrado, A . Mol. Cell. Biol. - 31 (6) : 1121-1133 (PMID: 21245377) (doi:10.1128/MCB.01204-10)
1 Dec | 2010 Targeting heme oxygenase-1 for neuroprotection and neuroinflammation in neurodegenerative diseases. Jazwa, A , Cuadrado, A . Curr Drug Targets - 11 (12) : 1517-1531 (PMID: 20704549)
1 Aug | 2010 The purinergic P2Y(13) receptor activates the Nrf2/HO-1 axis and protects against oxidative stress-induced neuronal death. Espada, S , Ortega, F, Molina-Jijón, E, Rojo, AI , Pérez-Sen, R, Pedraza-Chaverri, J, Miras-Portugal, MT, Cuadrado, A . Free Radic. Biol. Med. - 49 (3) : 416-426 (PMID: 20447456) (doi:10.1016/j.freeradbiomed.2010.04.031)
28 Jul | 2010 Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1. Innamorato, NG , Jazwa, A , Rojo, AI , García, C, Fernández-Ruiz, J, Grochot-Przeczek, A, Stachurska, A, Jozkowicz, A, Dulak, J, Cuadrado, A . PLoS ONE - 5 (7) : e11838 (PMID: 20676377) (doi:10.1371/journal.pone.0011838)
15 May | 2010 Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis. Niso-Santano, M, González-Polo, RA, Bravo-San Pedro, JM, Gómez-Sánchez, R, Lastres-Becker, I , Ortiz-Ortiz, MA, Soler, G, Morán, JM, Cuadrado, A , Fuentes, JM, , . Free Radic. Biol. Med. - 48 (10) : 1370-1381 (PMID: 20202476) (doi:10.1016/j.freeradbiomed.2010.02.024)
27 Apr | 2010 Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease. Rojo, AI , Innamorato, NG , Martín-Moreno, AM, De Ceballos, ML, Yamamoto, M, Cuadrado, A . Glia - 58 (5) : 588-598 (PMID: 19908287) (doi:10.1002/glia.20947)
13 Jan | 2010 Fibroblast growth factor-1 within the ventral tegmental area participates in motor sensitizing effects of morphine. Flores, JA, Galan-Rodriguez, B, Rojo, AI , Ramiro-Fuentes, S, Cuadrado, A , Fernandez-Espejo, E. Neuroscience - 165 (1) : 198-211 (PMID: 19819303) (doi:10.1016/j.neuroscience.2009.10.009)
1 Nov | 2009 Haeme oxygenase-1 overexpression via nAChRs and the transcription factor Nrf2 has antinociceptive effects in the formalin test. Egea, J, Rosa, AO, Lorrio, S, del Barrio, L, Cuadrado, A , López, MG. Pain - 146 (1-2) : 75-83 (PMID: 19660867) (doi:10.1016/j.pain.2009.07.007)
7 Aug | 2009 The muscarinic M1 receptor activates Nrf2 through a signaling cascade that involves protein kinase C and inhibition of GSK-3beta: connecting neurotransmission with neuroprotection. Espada, S , Rojo, AI , Salinas, M , Cuadrado, A . J. Neurochem. - 110 (3) : 1107-1119 (PMID: 19558456) (doi:10.1111/j.1471-4159.2009.06208.x)
15 Jun | 2009 Heme oxygenase-1 induction modulates microsomal prostaglandin E synthase-1 expression and prostaglandin E(2) production in osteoarthritic chondrocytes. Megías, J, Guillén, MI, Clérigues, V, Rojo, AI , Cuadrado, A , Castejón, MA, Gomar, F, Alcaraz, MJ. Biochem. Pharmacol. - 77 (12) : 1806-1813 (PMID: 19428335) (doi:10.1016/j.bcp.2009.03.009)
1 Jun | 2009 Role of microglial redox balance in modulation of neuroinflammation. Innamorato, NG , Lastres-Becker, I , Cuadrado, A . Curr. Opin. Neurol. - 22 (3) : 308-314 (PMID: 19359988) (doi:10.1097/WCO.0b013e32832a3225)
1 Mar | 2009 The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease. Cuadrado, A , Moreno-Murciano, P , Pedraza-Chaverri, J. Expert Opin. Ther. Targets - 13 (3) : 319-329 (PMID: 19236154) (doi:10.1517/13543780802716501)
12 Dec | 2008 Nordihydroguaiaretic acid activates the antioxidant pathway Nrf2/HO-1 and protects cerebellar granule neurons against oxidative stress. Guzmán-Beltrán, S, Espada, S , Orozco-Ibarra, M, Pedraza-Chaverri, J, Cuadrado, A . Neurosci. Lett. - 447 (2-3) : 167-171 (PMID: 18852027) (doi:10.1016/j.neulet.2008.09.079)
1 Sep | 2008 Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death. Rojo, AI , Rada, P , Egea, J, Rosa, AO, López, MG, Cuadrado, A . Mol. Cell. Neurosci. - 39 (1) : 125-132 (PMID: 18619545) (doi:10.1016/j.mcn.2008.06.007)
15 Jul | 2008 Nrf2-mediated haeme oxygenase-1 up-regulation induced by cobalt protoporphyrin has antinociceptive effects against inflammatory pain in the formalin test in mice. Rosa, AO, Egea, J, Lorrio, S, Rojo, AI , Cuadrado, A , López, MG. Pain - 137 (2) : 332-339 (PMID: 17964723) (doi:10.1016/j.pain.2007.09.015)
1 Jul | 2008 The transcription factor Nrf2 is a therapeutic target against brain inflammation. Innamorato, NG , Rojo, AI , García-Yagüe, AJ , Yamamoto, M, de Ceballos, ML, Cuadrado, A . J. Immunol. - 181 (1) : 680-689 (PMID: 18566435)
7 May | 2008 Heme oxygenase-1 as a therapeutic target in neurodegenerative diseases and brain infections. Cuadrado, A , Rojo, AI . Curr. Pharm. Des. - 14 (5) : 429-442 (PMID: 18289070)
28 Apr | 2008 GSK-3beta down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress. Rojo, AI , Sagarra, MR , Cuadrado, A . J. Neurochem. - 105 (1) : 192-202 (PMID: 18005231) (doi:10.1111/j.1471-4159.2007.05124.x)
1 Nov | 2007 Chronic inhalation of rotenone or paraquat does not induce Parkinson's disease symptoms in mice or rats. Rojo, AI , Cavada, C, de Sagarra, MR , Cuadrado, A . Exp. Neurol. - 208 (1) : 120-126 (PMID: 17880941) (doi:10.1016/j.expneurol.2007.07.022)
4 Sep | 2007 Nicotinic receptor activation by epibatidine induces heme oxygenase-1 and protects chromaffin cells against oxidative stress. Egea, J, Rosa, AO, Cuadrado, A , García, AG, López, MG. J. Neurochem. - 102 (6) : 1842-1852 (PMID: 17540012) (doi:10.1111/j.1471-4159.2007.04665.x)
15 Mar | 2007 Xanthine oxidase-derived extracellular superoxide anions stimulate activator protein 1 activity and hypertrophy in human vascular smooth muscle via c-Jun N-terminal kinase and p38 mitogen-activated protein kinases. Matesanz, N , Lafuente, N, Azcutia, V, Martín, D , Cuadrado, A , Nevado, J , Rodríguez-Mañas, L, Sánchez-Ferrer, CF, Peiró, C. J. Hypertens. - 25 (3) : 609-618 (PMID: 17278978) (doi:10.1097/HJH.0b013e328013e7c4)
27 Oct | 2006 Persistent penetration of MPTP through the nasal route induces Parkinson's disease in mice. Rojo, AI , Montero, C, Salazar, M , Close, RM, Fernández-Ruiz, J, Sánchez-González, MA, de Sagarra, MR , Jackson-Lewis, V, Cavada, C, Cuadrado, A . Eur. J. Neurosci. - 24 (7) : 1874-1884 (PMID: 17067291) (doi:10.1111/j.1460-9568.2006.05060.x)
15 Jul | 2006 Regulation of heme oxygenase-1 gene expression through the phosphatidylinositol 3-kinase/PKC-zeta pathway and Sp1. Rojo, AI , Salina, M, Salazar, M , Takahashi, S, Suske, G, Calvo, V , de Sagarra, MR , Cuadrado, A . Free Radic. Biol. Med. - 41 (2) : 247-261 (PMID: 16814105) (doi:10.1016/j.freeradbiomed.2006.04.002)
26 May | 2006 Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2. Salazar, M , Rojo, AI , Velasco, D , de Sagarra, RM , Cuadrado, A . J. Biol. Chem. - 281 (21) : 14841-14851 (PMID: 16551619) (doi:10.1074/jbc.M513737200)
26 May | 2006 Interleukin-1beta enhances GABAA receptor cell-surface expression by a phosphatidylinositol 3-kinase/Akt pathway: relevance to sepsis-associated encephalopathy. Serantes, R , Arnalich, F, Figueroa, M, Salinas, M , Andrés-Mateos, E, Codoceo, R, Renart, J , Matute, C, Cavada, C, Cuadrado, A , Montiel, C. J. Biol. Chem. - 281 (21) : 14632-14643 (PMID: 16567807) (doi:10.1074/jbc.M512489200)
21 Apr | 2006 Inhibition of heme oxygenase-1 interferes with the transforming activity of the Kaposi sarcoma herpesvirus-encoded G protein-coupled receptor. Marinissen, MJ , Tanos, T, Bolós, M , de Sagarra, MR , Coso, OA, Cuadrado, A . J. Biol. Chem. - 281 (16) : 11332-11346 (PMID: 16476737) (doi:10.1074/jbc.M512199200)
3 Dec | 2004 Protein kinase Akt/PKB phosphorylates heme oxygenase-1 in vitro and in vivo. Salinas, M , Wang, J, Rosa de Sagarra, M, Martín, D , Rojo, AI , Martin-Perez, J , Ortiz de Montellano, PR, Cuadrado, A . FEBS Lett. - 578 (1-2) : 90-94 (PMID: 15581622) (doi:10.1016/j.febslet.2004.10.077)
18 Aug | 2004 Regulation of Cu/Zn-superoxide dismutase expression via the phosphatidylinositol 3 kinase/Akt pathway and nuclear factor-kappaB. Rojo, AI , Salinas, M , Martín, D , Perona, R , Cuadrado, A . J. Neurosci. - 24 (33) : 7324-7334 (PMID: 15317858) (doi:10.1523/JNEUROSCI.2111-04.2004)
1 Aug | 2004 Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells. Sánchez-Sánchez, N, Riol-Blanco, L, de la Rosa, G, Puig-Kröger, A, García-Bordas, J, Martín, D , Longo, N, Cuadrado, A , Cabañas, C, Corbí, AL, Sánchez-Mateos, P, Rodríguez-Fernández, JL. Blood - 104 (3) : 619-625 (PMID: 15059845) (doi:10.1182/blood-2003-11-3943)
16 Apr | 2004 Signaling through the leukocyte integrin LFA-1 in T cells induces a transient activation of Rac-1 that is regulated by Vav and PI3K/Akt-1. Sánchez-Martín, L, Sánchez-Sánchez, N, Gutiérrez-López, MD, Rojo, AI , Vicente-Manzanares, M, Pérez-Alvarez, MJ, Sánchez-Mateos, P, Bustelo, XR, Cuadrado, A , Sánchez-Madrid, F, Rodríguez-Fernández, JL, Cabañas, C. J. Biol. Chem. - 279 (16) : 16194-16205 (PMID: 14960575) (doi:10.1074/jbc.M400905200)
5 Mar | 2004 Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol. Martin, D, Rojo, AI , Salinas, M , Diaz, R, Gallardo, G, Alam, J, De Galarreta, CM, Cuadrado, A . J. Biol. Chem. - 279 (10) : 8919-8929 (PMID: 14688281) (doi:10.1074/jbc.M309660200)
18 Apr | 2003 Nerve growth factor protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a phosphatidylinositol 3-kinase-dependent manner. Salinas, M , Diaz, R, Abraham, NG, Ruiz de Galarreta, CM, Cuadrado, A . J. Biol. Chem. - 278 (16) : 13898-13904 (PMID: 12578834) (doi:10.1074/jbc.M209164200)
8 Nov | 2002 Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B. Martin, D, Salinas, M , Fujita, N, Tsuruo, T, Cuadrado, A . J. Biol. Chem. - 277 (45) : 42943-42952 (PMID: 12213802) (doi:10.1074/jbc.M201070200)
23 May | 2002 Insulin restores differentiation of Ras-transformed C2C12 myoblasts by inducing NF-kappaB through an AKT/P70S6K/p38-MAPK pathway. Conejo, R, de Alvaro, C, Benito, M, Cuadrado, A , Lorenzo, M. Oncogene - 21 (23) : 3739-3753 (PMID: 12032842) (doi:10.1038/sj.onc.1205469)
12 Sep | 2001 Effect of the Alzheimer amyloid fragment Abeta(25-35) on Akt/PKB kinase and survival of PC12 cells. Martín, D , Salinas, M , López-Valdaliso, R , Serrano, E, Recuero, M, Cuadrado, A . J. Neurochem. - 78 (5) : 1000-1008 (PMID: 11553674)
1 Jan | 2001 Akt1/PKBalpha protects PC12 cells against the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium and reduces the levels of oxygen-free radicals. Salinas, M , Martín, D , Alvarez, A, Cuadrado, A . Mol. Cell. Neurosci. - 17 (1) : 67-77 (PMID: 11161470) (doi:10.1006/mcne.2000.0921)
1 Feb | 2000 Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells. Salinas, M , López-Valdaliso, R , Martín, D , Alvarez, A, Cuadrado, A . Mol. Cell. Neurosci. - 15 (2) : 156-169 (PMID: 10673324) (doi:10.1006/mcne.1999.0813)
24 Jul | 1998 Activation of Akt/protein kinase B by G protein-coupled receptors. A role for alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinasegamma. Murga, C, Laguinge, L, Wetzker, R, Cuadrado, A , Gutkind, JS. J. Biol. Chem. - 273 (30) : 19080-19085 (PMID: 9668091)
21 Jun | 1994 Uneven distribution of protein kinase C-alpha and -beta isozymes in human sarcomas and carcinomas. Cuadrado, A , Issing, W, Fleming, TP, Molloy, CJ. J. Cell. Physiol. - 159 (3) : 434-440 (PMID: 8188761) (doi:10.1002/jcp.1041590307)
10 May | 1994 Activation of type D phospholipase by serum stimulation and ras-induced transformation in NIH3T3 cells. Carnero, A, Cuadrado, A , del Peso, L , Lacal, JC . Oncogene - 9 (5) : 1387-1395 (PMID: 8152799)
24 Nov | 1993 Phosphorylcholine: a novel second messenger essential for mitogenic activity of growth factors. Cuadrado, A , Carnero, A, Dolfi, F, Jiménez, B , Lacal, JC . Oncogene - 8 (11) : 2959-2968 (PMID: 8414498)
28 Sep | 1993 H-ras and raf-1 cooperate in transformation of NIH3T3 fibroblasts. Cuadrado, A , Bruder, JT, Heidaran, MA, App, H, Rapp, UR, Aaronson, SA. Oncogene - 8 (9) : 2443-2448 (PMID: 8361757)
2 Aug | 1993 Acylphosphatase synergizes with progesterone during maturation of Xenopus laevis oocytes. Dolfi, F, Carnero, A, Cuadrado, A , Ramponi, G, Lacal, JC . FEBS Lett. - 327 (3) : 265-270 (PMID: 8394242)
23 Sep | 1992 Platelet-derived growth factor stimulation of GTPase-activating protein tyrosine phosphorylation in control and c-H-ras-expressing NIH 3T3 cells correlates with p21ras activation. Molloy, CJ, Fleming, TP, Bottaro, DP, Cuadrado, A , Aaronson, SA. Mol. Cell. Biol. - 12 (9) : 3903-3909 (PMID: 1508192)
1 Dec | 1990 The probability of G1 cells to enter into S increases with their size while S length decreases with cell enlargement in Allium cepa. Cánovas, JL, Cuadrado, A , Escalera, M, Navarrete, MH. Exp. Cell Res. - 191 (2) : 163-170 (PMID: 2257874)
1 Nov | 1990 Overexpression of phospholipase C-gamma in NIH 3T3 fibroblasts results in increased phosphatidylinositol hydrolysis in response to platelet-derived growth factor and basic fibroblast growth factor. Cuadrado, A , Molloy, CJ. Mol. Cell. Biol. - 10 (11) : 6069-6072 (PMID: 2172791)
31 Jul | 1990 Increased tyrosine phosphorylation in ras transformed fibroblasts occurs prior to manifestation of the transformed phenotype. Cuadrado, A . Biochem. Biophys. Res. Commun. - 170 (2) : 526-532 (PMID: 2200402)
25 Jun | 1990 Regulation of protein kinase C activity in neuronal differentiation induced by the N-ras oncogene in PC-12 cells. Lacal, JC , Cuadrado, A , Jones, JE, Trotta, R, Burstein, DE, Thomson, T, Pellicer, A. Mol. Cell. Biol. - 10 (6) : 2983-2990 (PMID: 2188105)
29 Jan | 1990 Expression of protein kinase CI in NIH 3T3 cells increases its growth response to specific activators. Cuadrado, A , Molloy, CJ, Pech, M. FEBS Lett. - 260 (2) : 281-284 (PMID: 2298303)
1 Nov | 1989 Cell size of proliferating plant cells increases with temperature: implications in the control of cell division. Cuadrado, A , Navarrete, MH, Canovas, JL. Exp. Cell Res. - 185 (1) : 277-282 (PMID: 2806410)
1 Mar | 1989 Exponential pattern of cell age distribution in dividing cells of plant meristems. Cuadrado, A , Navarrete, MH, Canovas, JL. Cell Biol. Int. Rep. - 13 (3) : 283-289 (PMID: 2706689)
1 Jun | 1987 Regulation of G2 by cell size contributes to maintaining cell size variability within certain limits in higher plants. Navarrete, MH, Cuadrado, A , Escalera, M, Cánovas, JL. J. Cell. Sci. - 87 ( Pt 5) : 635-641 (PMID: 3667721)
1 Jun | 1985 The effect of partial protein synthesis inhibition on cell proliferation in higher plants. Cuadrado, A , Navarrete, MH, Cánovas, JL. J. Cell. Sci. - 76 : 97-9104 (PMID: 4066798)
15 Oct | 1983 Partial elimination of G1 and G2 periods in higher plant cells by increasing the S period. Navarrete, MH, Cuadrado, A , Cánovas, JL. Exp. Cell Res. - 148 (2) : 273-280 (PMID: 6628558)