3 Mar | 2024 Cardiolipin Membranes Promote Cytochrome c Transformation of Polycyclic Aromatic Hydrocarbons and Their In Vivo Metabolites. Lopes, J, Marques-da-Silva, D, Videira, PA, Samhan-Arias, AK , Lagoa, R. Molecules - 29 (5) (PMID: 38474641) (doi:10.3390/molecules29051129)
2 Dec | 2023 Are There Lipid Membrane-Domain Subtypes in Neurons with Different Roles in Calcium Signaling? Samhan-Arias, AK , Poejo, J, Marques-da-Silva, D, Martínez-Costa, OH , Gutierrez-Merino, C. Molecules - 28 (23) (PMID: 38067638) (doi:10.3390/molecules28237909)
17 Oct | 2023 Hexa-Histidine, a Peptide with Versatile Applications in the Study of Amyloid-β(1-42) Molecular Mechanisms of Action. Salazar, J, Samhan-Arias, AK , Gutierrez-Merino, C. Molecules - 28 (20) (PMID: 37894616) (doi:10.3390/molecules28207138)
23 Dec | 2022 The Use of Flavylium Salts as Dynamic Inhibitor Moieties for Human Cb5R. Martínez-Costa, OH , Rodrigues-Miranda, L, Clemente, SM, Parola, AJ, Basilio, N, Samhan-Arias, AK . Molecules - 28 (1) (PMID: 36615312) (doi:10.3390/molecules28010123)
2 Dec | 2022 Biochemical and Biophysical Characterization of the Caveolin-2 Interaction with Membranes and Analysis of the Protein Structural Alteration by the Presence of Cholesterol. Gorospe, B, Moura, JJG, Gutierrez-Merino, C, Samhan-Arias, AK . Int J Mol Sci - 23 (23) (PMID: 36499524) (doi:10.3390/ijms232315203)
18 Feb | 2022 Design and Experimental Evaluation of a Peptide Antagonist against Amyloid β(1-42) Interactions with Calmodulin and Calbindin-D28k. Salazar, J, Poejo, J, Mata, AM, Samhan-Arias, AK , Gutierrez-Merino, C. Int J Mol Sci - 23 (4) (PMID: 35216403) (doi:10.3390/ijms23042289)
23 Dec | 2021 Structural Features of Cytochrome b5-Cytochrome b5 Reductase Complex Formation and Implications for the Intramolecular Dynamics of Cytochrome b5 Reductase. Gutiérrez-Merino, C, Martínez-Costa, OH , Monsalve, M , Samhan-Arias, AK . Int J Mol Sci - 23 (1) (PMID: 35008543) (doi:10.3390/ijms23010118)
9 Apr | 2021 Mitophagy in Human Diseases. Doblado, L , Lueck, C , Rey, C , Samhan-Arias, AK , Prieto, I , Stacchiotti, A, Monsalve, M . Int J Mol Sci - 22 (8) (PMID: 33918863) (doi:10.3390/ijms22083903)
5 Nov | 2020 Targeting Lipid Peroxidation for Cancer Treatment. Clemente, SM, Martínez-Costa, OH , Monsalve, M , Samhan-Arias, AK . Molecules - 25 (21) (PMID: 33167334) (doi:10.3390/molecules25215144)
1 Feb | 2020 Human erythrocytes exposure to juglone leads to an increase of superoxide anion production associated with cytochrome b5 reductase uncoupling. Valério, GN, Gutiérrez-Merino, C, Nogueira, F, Moura, I, Moura, JJG, Samhan-Arias, AK . Biochim Biophys Acta Bioenerg - 1861 (2) : 148134 (PMID: 31825806) (doi:10.1016/j.bbabio.2019.148134)
1 May | 2019 Ligand accessibility to heme cytochrome b5 coordinating sphere and enzymatic activity enhancement upon tyrosine ionization. Samhan-Arias, AK , Cordas, CM, Carepo, MS, Maia, LB, Gutierrez-Merino, C, Moura, I, Moura, JJG. J Biol Inorg Chem - 24 (3) : 317-330 (PMID: 30838452) (doi:10.1007/s00775-019-01649-2)
1 May | 2018 Cytochrome b5 reductase is the component from neuronal synaptic plasma membrane vesicles that generates superoxide anion upon stimulation by cytochrome c. Samhan-Arias, AK , Fortalezas, S, Cordas, CM, Moura, I, Moura, JJG, Gutierrez-Merino, C. Redox Biol - 15 : 109-114 (PMID: 29227865) (doi:10.1016/j.redox.2017.11.021)
1 May | 2018 Structural characterization of cardiolipin-driven activation of cytochrome c into a peroxidase and membrane perturbation. Mohammadyani, D, Yanamala, N, Samhan-Arias, AK , Kapralov, AA, Stepanov, G, Nuar, N, Planas-Iglesias, J, Sanghera, N, Kagan, VE, Klein-Seetharaman, J. Biochim Biophys Acta Biomembr - 1860 (5) : 1057-1068 (PMID: 29317202) (doi:10.1016/j.bbamem.2018.01.009)
1 Feb | 2018 Peroxidase-like activity of cytochrome b5 is triggered upon hemichrome formation in alkaline pH. Samhan-Arias, AK , Maia, LB, Cordas, CM, Moura, I, Gutierrez-Merino, C, Moura, JJG. Biochim Biophys Acta Proteins Proteom - 1866 (2) : 373-378 (PMID: 28958890) (doi:10.1016/j.bbapap.2017.09.010)
1 Feb | 2018 Topography of human cytochrome b5/cytochrome b5 reductase interacting domain and redox alterations upon complex formation. Samhan-Arias, AK , Almeida, RM, Ramos, S, Cordas, CM, Moura, I, Gutierrez-Merino, C, Moura, JJG. Biochim Biophys Acta Bioenerg - 1859 (2) : 78-87 (PMID: 29111436) (doi:10.1016/j.bbabio.2017.10.005)
6 May | 2017 Correlation between the potency of flavonoids for cytochrome c reduction and inhibition of cardiolipin-induced peroxidase activity. Lagoa, R, Samhan-Arias, AK , Gutierrez-Merino, C. Biofactors - 43 (3) : 451-468 (PMID: 28317253) (doi:10.1002/biof.1357)
1 May | 2016 High expression of cytochrome b 5 reductase isoform 3/cytochrome b 5 system in the cerebellum and pyramidal neurons of adult rat brain. Samhan-Arias, AK , López-Sánchez, C, Marques-da-Silva, D, Lagoa, R, Garcia-Lopez, V, García-Martínez, V, Gutierrez-Merino, C. Brain Struct Funct - 221 (4) : 2147-2162 (PMID: 25850901) (doi:10.1007/s00429-015-1036-5)
1 Aug | 2014 Purified NADH-cytochrome b5 reductase is a novel superoxide anion source inhibited by apocynin: sensitivity to nitric oxide and peroxynitrite. Samhan-Arias, AK , Gutierrez-Merino, C. Free Radic Biol Med - 73 : 174-189 (PMID: 24816293) (doi:10.1016/j.freeradbiomed.2014.04.033)
1 Oct | 2012 Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury. Ji, J, Kline, AE, Amoscato, A, Samhan-Arias, AK , Sparvero, LJ, Tyurin, VA, Tyurina, YY, Fink, B, Manole, MD, Puccio, AM, Okonkwo, DO, Cheng, JP, Alexander, H, Clark, RS, Kochanek, PM, Wipf, P, Kagan, VE, Bayır, H. Nat Neurosci - 15 (10) : 1407-1413 (PMID: 22922784) (doi:10.1038/nn.3195)
1 Oct | 2012 Oxidized phospholipids as biomarkers of tissue and cell damage with a focus on cardiolipin. Samhan-Arias, AK , Ji, J, Demidova, OM, Sparvero, LJ, Feng, W, Tyurin, V, Tyurina, YY, Epperly, MW, Shvedova, AA, Greenberger, JS, Bayır, H, Kagan, VE, Amoscato, AA. Biochim Biophys Acta - 1818 (10) : 2413-2423 (PMID: 22464971) (doi:10.1016/j.bbamem.2012.03.014)
6 Jun | 2012 Stimulation and clustering of cytochrome b5 reductase in caveolin-rich lipid microdomains is an early event in oxidative stress-mediated apoptosis of cerebellar granule neurons. Samhan-Arias, AK , Marques-da-Silva, D, Yanamala, N, Gutierrez-Merino, C. J Proteomics - 75 (10) : 2934-2949 (PMID: 22200675) (doi:10.1016/j.jprot.2011.12.007)
11 Oct | 2011 A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death. Atkinson, J, Kapralov, AA, Yanamala, N, Tyurina, YY, Amoscato, AA, Pearce, L, Peterson, J, Huang, Z, Jiang, J, Samhan-Arias, AK , Maeda, A, Feng, W, Wasserloos, K, Belikova, NA, Tyurin, VA, Wang, H, Fletcher, J, Wang, Y, Vlasova, II, Klein-Seetharaman, J, Stoyanovsky, DA, Bayîr, H, Pitt, BR, Epperly, MW, Greenberger, JS, Kagan, VE. Nat Commun - 2 : 497 (PMID: 21988913) (doi:10.1038/ncomms1499)
27 Sep | 2011 Global phospholipidomics analysis reveals selective pulmonary peroxidation profiles upon inhalation of single-walled carbon nanotubes. Tyurina, YY, Kisin, ER, Murray, A, Tyurin, VA, Kapralova, VI, Sparvero, LJ, Amoscato, AA, Samhan-Arias, AK , Swedin, L, Lahesmaa, R, Fadeel, B, Shvedova, AA, Kagan, VE. ACS Nano - 5 (9) : 7342-7353 (PMID: 21800898) (doi:10.1021/nn202201j)
12 Sep | 2011 Topography of tyrosine residues and their involvement in peroxidation of polyunsaturated cardiolipin in cytochrome c/cardiolipin peroxidase complexes. Kapralov, AA, Yanamala, N, Tyurina, YY, Castro, L, Samhan-Arias, A , Vladimirov, YA, Maeda, A, Weitz, AA, Peterson, J, Mylnikov, D, Demicheli, V, Tortora, V, Klein-Seetharaman, J, Radi, R, Kagan, VE. Biochim Biophys Acta - 1808 (9) : 2147-2155 (PMID: 21550335) (doi:10.1016/j.bbamem.2011.04.009)
1 Aug | 2011 Neuroprotective actions of flavonoids. Gutierrez-Merino, C, Lopez-Sanchez, C, Lagoa, R, Samhan-Arias, AK , Bueno, C, Garcia-Martinez, V. Curr Med Chem - 18 (8) : 1195-1212 (PMID: 21291366) (doi:10.2174/092986711795029735)
1 Mar | 2011 Early disruption of the actin cytoskeleton in cultured cerebellar granule neurons exposed to 3-morpholinosydnonimine-oxidative stress is linked to alterations of the cytosolic calcium concentration. Tiago, T, Marques-da-Silva, D, Samhan-Arias, AK , Aureliano, M, Gutierrez-Merino, C. Cell Calcium - 49 (3) : 174-183 (PMID: 21356558) (doi:10.1016/j.ceca.2011.01.009)
1 Jan | 2011 Lipid antioxidants: free radical scavenging versus regulation of enzymatic lipid peroxidation. Samhan-Arias, AK , Tyurina, YY, Kagan, VE. J Clin Biochem Nutr - 48 (1) : 91-95 (PMID: 21297919) (doi:10.3164/jcbn.11-009FR)
10 Aug | 2010 Phosphomimetic substitution of cytochrome C tyrosine 48 decreases respiration and binding to cardiolipin and abolishes ability to trigger downstream caspase activation. Pecina, P, Borisenko, GG, Belikova, NA, Tyurina, YY, Pecinova, A, Lee, I, Samhan-Arias, AK , Przyklenk, K, Kagan, VE, Hüttemann, M. Biochemistry - 49 (31) : 6705-6714 (PMID: 20586425) (doi:10.1021/bi100486s)
7 Jul | 2010 Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice. Hiona, A, Sanz, A, Kujoth, GC, Pamplona, R, Seo, AY, Hofer, T, Someya, S, Miyakawa, T, Nakayama, C, Samhan-Arias, AK , Servais, S, Barger, JL, Portero-Otín, M, Tanokura, M, Prolla, TA, Leeuwenburgh, C. PLoS One - 5 (7) : e11468 (PMID: 20628647) (doi:10.1371/journal.pone.0011468)
16 Jun | 2010 L-type calcium channels and cytochrome b5 reductase are components of protein complexes tightly associated with lipid rafts microdomains of the neuronal plasma membrane. Marques-da-Silva, D, Samhan-Arias, AK , Tiago, T, Gutierrez-Merino, C. J Proteomics - 73 (8) : 1502-1510 (PMID: 20188223) (doi:10.1016/j.jprot.2010.02.014)
30 Nov | 2009 Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions. Kagan, VE, Wipf, P, Stoyanovsky, D, Greenberger, JS, Borisenko, G, Belikova, NA, Yanamala, N, Samhan Arias, AK , Tungekar, MA, Jiang, J, Tyurina, YY, Ji, J, Klein-Seetharaman, J, Pitt, BR, Shvedova, AA, Bayir, H. Adv Drug Deliv Rev - 61 (14) : 1375-1385 (PMID: 19716396) (doi:10.1016/j.addr.2009.06.008)
30 Oct | 2009 Hydrogen sulfide is a reversible inhibitor of the NADH oxidase activity of synaptic plasma membranes. Samhan-Arias, AK , Garcia-Bereguiain, MA, Gutierrez-Merino, C. Biochem Biophys Res Commun - 388 (4) : 718-722 (PMID: 19695225) (doi:10.1016/j.bbrc.2009.08.076)
22 Oct | 2009 Kaempferol protects against rat striatal degeneration induced by 3-nitropropionic acid. Lagoa, R, Lopez-Sanchez, C, Samhan-Arias, AK , Gañan, CM, Garcia-Martinez, V, Gutierrez-Merino, C. J Neurochem - 111 (2) : 473-487 (PMID: 19682208) (doi:10.1111/j.1471-4159.2009.06331.x)
19 Aug | 2009 Heterolytic reduction of fatty acid hydroperoxides by cytochrome c/cardiolipin complexes: antioxidant function in mitochondria. Belikova, NA, Tyurina, YY, Borisenko, G, Tyurin, V, Samhan Arias, AK , Yanamala, N, Furtmüller, PG, Klein-Seetharaman, J, Obinger, C, Kagan, VE. J Am Chem Soc - 131 (32) : 11288-11289 (PMID: 19627079) (doi:10.1021/ja904343c)
27 Jan | 2009 Clustering of plasma membrane-bound cytochrome b5 reductase within 'lipid raft' microdomains of the neuronal plasma membrane. Samhan-Arias, AK , Garcia-Bereguiain, MA, Martin-Romero, FJ, Gutierrez-Merino, C. Mol Cell Neurosci - 40 (1) : 14-26 (PMID: 18973815) (doi:10.1016/j.mcn.2008.08.013)
15 Jan | 2008 Reduction of ascorbate free radical by the plasma membrane of synaptic terminals from rat brain. Samhan-Arias, AK , Duarte, RO, Martín-Romero, FJ, Moura, JJ, Gutiérrez-Merino, C. Arch Biochem Biophys - 469 (2) : 243-254 (PMID: 17963686) (doi:10.1016/j.abb.2007.10.004)
1 Jan | 2008 Hydrogen sulfide raises cytosolic calcium in neurons through activation of L-type Ca2+ channels. García-Bereguiaín, MA, Samhan-Arias, AK , Martín-Romero, FJ, Gutiérrez-Merino, C. Antioxid Redox Signal - 10 (1) : 31-42 (PMID: 17956188) (doi:10.1089/ars.2007.1656)
28 Nov | 2007 Blood micromolar concentrations of kaempferol afford protection against ischemia/reperfusion-induced damage in rat brain. López-Sánchez, C, Martín-Romero, FJ, Sun, F, Luis, L, Samhan-Arias, AK , García-Martínez, V, Gutiérrez-Merino, C. Brain Res - 1182 : 123-137 (PMID: 17950707) (doi:10.1016/j.brainres.2007.08.087)
1 May | 2006 Regionalization of plasma membrane-bound flavoproteins of cerebellar granule neurons in culture by fluorescence energy transfer imaging. Samhan-Arias, AK , García-Bereguiaín, MA, Martín-Romero, FJ, Gutiérrez-Merino, C. J Fluoresc - 16 (3) : 393-401 (PMID: 16538396) (doi:10.1007/s10895-005-0065-5)
1 Jul | 2004 Kaempferol blocks oxidative stress in cerebellar granule cells and reveals a key role for reactive oxygen species production at the plasma membrane in the commitment to apoptosis. Samhan-Arias, AK , Martín-Romero, FJ, Gutiérrez-Merino, C. Free Radic Biol Med - 37 (1) : 48-61 (PMID: 15183194) (doi:10.1016/j.freeradbiomed.2004.04.002)