18 Jan | 2025 Osmotic stress influences microtubule drug response via WNK1 kinase signaling. Monfort-Vengut, A , Sanz-Gómez, N , Ballesteros-Sánchez, S, Ortigosa, B , Cambón, A, Ramos, M, Lorenzo, ÁM, Escribano-Cebrián, M, Rosa-Rosa, JM, Martínez-López, J, Sánchez-Prieto, R , Sotillo, R, de Cárcer, G . Drug Resist Updat - 79 : 101203 (PMID: 39855050) (doi:10.1016/j.drup.2025.101203)
3 Dec | 2024 The CDK12-BRCA1 signaling axis mediates dinaciclib-associated radiosensitivity through p53-mediated cellular senescence. Flores, NG, Fernández-Aroca, DM, Garnés-García, C, Domínguez-Calvo, A, Jiménez-Suárez, J, Sabater, S, Fernández-Aroca, P, Andrés, I, Cimas, FJ, de Cárcer, G , Belandia, B , Palmero, I , Huertas, P, Ruiz-Hidalgo, MJ, Sánchez-Prieto, R . Mol Oncol (PMID: 39626031) (doi:10.1002/1878-0261.13773)
16 May | 2024 The Peptidoglycan Recognition Protein 1 confers immune evasive properties on pancreatic cancer stem cells. López-Gil, JC , García-Silva, S , Ruiz-Cañas, L , Navarro, D , Palencia-Campos, A , Giráldez-Trujillo, A, Earl, J, Dorado, J , Gómez-López, G, Monfort-Vengut, A , Alcalá, S , Gaida, MM, García-Mulero, S, Cabezas-Sáinz, P, Batres-Ramos, S , Barreto, E, Sánchez-Tomero, P , Vallespinós, M, Ambler, L, Lin, ML, Aicher, A, García García de Paredes, A, de la Pinta, C, Sanjuanbenito, A, Ruz-Caracuel, I, Rodríguez-Garrote, M, Guerra, C, Carrato, A, de Cárcer, G , Sánchez, L, Nombela-Arrieta, C, Espinet, E, Sanchez-Arevalo Lobo, VJ, Heeschen, C, Sainz, B . Gut (PMID: 38754953) (doi:10.1136/gutjnl-2023-330995)
15 Feb | 2024 TPX2 overexpression promotes sensitivity to dasatinib in breast cancer by activating YAP transcriptional signaling. Marugán, C, Sanz-Gómez, N , Ortigosa, B , Monfort-Vengut, A , Bertinetti, C , Teijo, A, González, M , Alonso de la Vega, A, Lallena, MJ, Moreno-Bueno, G , de Cárcer, G . Mol Oncol (PMID: 38357786) (doi:10.1002/1878-0261.13602)
1 Nov | 2023 PLK1 inhibition dampens NLRP3 inflammasome-elicited response in inflammatory disease models. Baldrighi, M, Doreth, C, Li, Y, Zhao, X, Warner, E, Chenoweth, H, Kishore, K, Umrania, Y, Minde, DP, Thome, S, Yu, X, Lu, Y, Knapton, A, Harrison, J, Clarke, M, Latz, E, de Cárcer, G , Malumbres, M, Ryffel, B, Bryant, C, Liu, J, Lilley, KS, Mallat, Z, Li, X. J Clin Invest - 133 (21) (PMID: 37698938) (doi:10.1172/JCI162129)
5 Jun | 2023 Whole-Genome Doubling as a source of cancer: how, when, where, and why? Sanz-Gómez, N , González-Álvarez, M , De Las Rivas, J, de Cárcer, G . Front Cell Dev Biol - 11 : 1209136 (PMID: 37342233) (doi:10.3389/fcell.2023.1209136)
13 Apr | 2023 Lights and Shadows on the Cancer Multi-Target Inhibitor Rigosertib (ON-01910.Na). Monfort-Vengut, A , de Cárcer, G . Pharmaceutics - 15 (4) (PMID: 37111716) (doi:10.3390/pharmaceutics15041232)
5 Nov | 2021 Mitotic Errors Promote Genomic Instability and Leukemia in a Novel Mouse Model of Fanconi Anemia. Edwards, DM, Mitchell, DK, Abdul-Sater, Z, Chan, KK, Sun, Z, Sheth, A, He, Y, Jiang, L, Yuan, J, Sharma, R, Czader, M, Chin, PJ, Liu, Y, de Cárcer, G , Nalepa, G, Broxmeyer, HE, Clapp, DW, Sierra Potchanant, EA. Front Oncol - 11 : 752933 (PMID: 34804941) (doi:10.3389/fonc.2021.752933)
23 Oct | 2021 Overcoming PLK1 inhibitor resistance by targeting mevalonate pathway to impair AXL-TWIST axis in colorectal cancer. Solanes-Casado, S, Cebrián, A , Rodríguez-Remírez, M, Mahíllo, I, García-García, L, Río-Vilariño, A, Baños, N, de Cárcer, G , Monfort-Vengut, A , Castellano, V, Fernández-Aceñero, MJ, García-Foncillas, J, Del Puerto-Nevado, L. Biomed Pharmacother - 144 : 112347 (PMID: 34700228) (doi:10.1016/j.biopha.2021.112347)
20 Feb | 2020 Squamous differentiation requires G2/mitosis slippage to avoid apoptosis. Sanz-Gómez, N , de Pedro, I, Ortigosa, B , Santamaría, D, Malumbres, M, de Cárcer, G , Gandarillas, A. Cell Death Differ. (PMID: 32080348) (doi:10.1038/s41418-020-0515-2)
11 Mar | 2019 The Mitotic Cancer Target Polo-Like Kinase 1: Oncogene or Tumor Suppressor? de Cárcer, G . Genes (Basel) - 10 (3) (PMID: 30862113) (doi:10.3390/genes10030208)
1 Aug | 2018 Plk1 overexpression induces chromosomal instability and suppresses tumor development. de Cárcer, G , Venkateswaran, SV, Salgueiro, L, El Bakkali, A, Somogyi, K, Rowald, K, Montañés, P, Sanclemente, M, Escobar, B, de Martino, A, McGranahan, N, Malumbres, M, Sotillo, R. Nat Commun - 9 (1) : 3012 (PMID: 30069007) (doi:10.1038/s41467-018-05429-5)
1 Aug | 2017 Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis. de Cárcer, G , Wachowicz, P, Martínez-Martínez, S, Oller, J, Méndez-Barbero, N, Escobar, B, González-Loyola, A, Takaki, T, El Bakkali, A, Cámara, JA, Jiménez-Borreguero, LJ, Bustelo, XR, Cañamero, M, Mulero, F, de Los Ángeles Sevilla, M, Montero, MJ, Redondo, JM, Malumbres, M. Nat. Med. - 23 (8) : 964-974 (PMID: 28692064) (doi:10.1038/nm.4364)
1 Jul | 2016 Genetic depletion of Polo-like kinase 1 leads to embryonic lethality due to mitotic aberrancies. Wachowicz, P, Fernández-Miranda, G, Marugán, C, Escobar, B, de Cárcer, G . Bioessays - 38 Suppl 1 : S96-S106 (PMID: 27417127) (doi:10.1002/bies.201670908)
19 Apr | 2016 Aurora A drives early signalling and vesicle dynamics during T-cell activation. Blas-Rus, N, Bustos-Morán, E, Pérez de Castro, I, de Cárcer, G , Borroto, A, Camafeita, E, Jorge, I, Vázquez, J, Alarcón, B, Malumbres, M, Martín-Cófreces, NB, Sánchez-Madrid, F. Nat Commun - 7 : 11389 (PMID: 27091106) (doi:10.1038/ncomms11389)
1 Oct | 2015 Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice. Trakala, M, Partida, D, Salazar-Roa, M, Maroto, M, Wachowicz, P, de Cárcer, G , Malumbres, M. Blood - 126 (14) : 1707-1714 (PMID: 26185128) (doi:10.1182/blood-2015-03-634402)
1 Oct | 2015 Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development. González-Loyola, A, Fernández-Miranda, G, Trakala, M, Partida, D, Samejima, K, Ogawa, H, Cañamero, M, de Martino, A, Martínez-Ramírez, Á, de Cárcer, G , Pérez de Castro, I, Earnshaw, WC, Malumbres, M. Mol. Cell. Biol. - 35 (20) : 3566-3578 (PMID: 26240282) (doi:10.1128/MCB.01286-14)
1 Jun | 2014 A centrosomal route for cancer genome instability. de Cárcer, G , Malumbres, M. Nat. Cell Biol. - 16 (6) : 504-506 (PMID: 24875738) (doi:10.1038/ncb2978)
24 Sep | 2013 Low dose of amino-modified nanoparticles induces cell cycle arrest. Kim, JA, Åberg, C, de Cárcer, G , Malumbres, M, Salvati, A, Dawson, KA. ACS Nano - 7 (9) : 7483-7494 (PMID: 23941353) (doi:10.1021/nn403126e)
14 Dec | 2012 HIF2α acts as an mTORC1 activator through the amino acid carrier SLC7A5. Elorza, A, Soro-Arnáiz, I, Meléndez-Rodríguez, F, Rodríguez-Vaello, V, Marsboom, G, de Cárcer, G , Acosta-Iborra, B , Albacete-Albacete, L, Ordóñez, A, Serrano-Oviedo, L, Giménez-Bachs, JM, Vara-Vega, A, Salinas, A, Sánchez-Prieto, R , Martín del Río, R, Sánchez-Madrid, F, Malumbres, M, Landázuri, MO, Aragonés, J. Mol. Cell - 48 (5) : 681-691 (PMID: 23103253) (doi:10.1016/j.molcel.2012.09.017)
15 Jul | 2011 From Plk1 to Plk5: functional evolution of polo-like kinases. de Cárcer, G , Manning, G, Malumbres, M. Cell Cycle - 10 (14) : 2255-2262 (PMID: 21654194) (doi:10.4161/cc.10.14.16494)
1 Mar | 2011 Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. de Cárcer, G , Escobar, B, Higuero, AM , García, L, Ansón, A, Pérez, G, Mollejo, M, Manning, G, Meléndez, B, Abad-Rodríguez, J, Malumbres, M. Mol. Cell. Biol. - 31 (6) : 1225-1239 (PMID: 21245385) (doi:10.1128/MCB.00607-10)
1 Jan | 2011 Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin. Muñoz, IG, Yébenes, H, Zhou, M, Mesa, P, Serna, M, Park, AY, Bragado-Nilsson, E, Beloso, A, de Cárcer, G , Malumbres, M, Robinson, CV, Valpuesta, JM, Montoya, G. Nat. Struct. Mol. Biol. - 18 (1) : 14-19 (PMID: 21151115) (doi:10.1038/nsmb.1971)
14 Dec | 2010 Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase. Manchado, E, Guillamot, M, de Cárcer, G , Eguren, M, Trickey, M, García-Higuera, I, Moreno, S, Yamano, H, Cañamero, M, Malumbres, M. Cancer Cell - 18 (6) : 641-654 (PMID: 21156286) (doi:10.1016/j.ccr.2010.10.028)
15 Nov | 2010 Brick1 is an essential regulator of actin cytoskeleton required for embryonic development and cell transformation. Escobar, B, de Cárcer, G , Fernández-Miranda, G, Cascón, A, Bravo-Cordero, JJ, Montoya, MC, Robledo, M, Cañamero, M, Malumbres, M. Cancer Res. - 70 (22) : 9349-9359 (PMID: 20861187) (doi:10.1158/0008-5472.CAN-09-4491)
1 Aug | 2010 RINGO C is required to sustain the spindle-assembly checkpoint. Mourón, S, de Cárcer, G , Seco, E, Fernández-Miranda, G, Malumbres, M, Nebreda, AR. J. Cell. Sci. - 123 (Pt 15) : 2586-2595 (PMID: 20605920) (doi:10.1242/jcs.059964)
1 Mar | 2009 TRF1 controls telomere length and mitotic fidelity in epithelial homeostasis. Muñoz, P, Blanco, R, de Carcer, G , Schoeftner, S, Benetti, R, Flores, JM, Malumbres, M, Blasco, MA. Mol. Cell. Biol. - 29 (6) : 1608-1625 (PMID: 19124610) (doi:10.1128/MCB.01339-08)
1 Aug | 2008 Emerging cancer therapeutic opportunities by inhibiting mitotic kinases. Pérez de Castro, I, de Cárcer, G , Montoya, G, Malumbres, M. Curr Opin Pharmacol - 8 (4) : 375-383 (PMID: 18644252) (doi:10.1016/j.coph.2008.06.013)
8 May | 2007 Targeting cell cycle kinases for cancer therapy. de Cárcer, G , Pérez de Castro, I, Malumbres, M. Curr. Med. Chem. - 14 (9) : 969-985 (PMID: 17439397)
1 May | 2007 A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy. Pérez de Castro, I, de Cárcer, G , Malumbres, M. Carcinogenesis - 28 (5) : 899-912 (PMID: 17259655) (doi:10.1093/carcin/bgm019)
27 Feb | 2007 Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization. García-Alvarez, B, de Cárcer, G , Ibañez, S, Bragado-Nilsson, E, Montoya, G. Proc. Natl. Acad. Sci. U.S.A. - 104 (9) : 3107-3112 (PMID: 17307877) (doi:10.1073/pnas.0609131104)
1 Aug | 2004 Heat shock protein 90 regulates the metaphase-anaphase transition in a polo-like kinase-dependent manner. de Cárcer, G . Cancer Res. - 64 (15) : 5106-5112 (PMID: 15289312) (doi:10.1158/0008-5472.CAN-03-2214)
1 Jun | 2001 Requirement of Hsp90 for centrosomal function reflects its regulation of Polo kinase stability. de Cárcer, G , do Carmo Avides, M, Lallena, MJ, Glover, DM, González, C. EMBO J. - 20 (11) : 2878-2884 (PMID: 11387220) (doi:10.1093/emboj/20.11.2878)
1 Oct | 2000 The functional organization of the nucleolus in proliferating plant cells. Medina, FJ, Cerdido, A, de Cárcer, G . Eur J Histochem - 44 (2) : 117-131 (PMID: 10968360)
21 Dec | 1999 The N-terminal 209-aa domain of high molecular-weight 4.1R isoforms abrogates 4.1R targeting to the nucleus. Luque, CM, Lallena, MJ, Pérez-Ferreiro, CM, de Isidro, Y, De Cárcer, G , Alonso, MA, Correas, I. Proc. Natl. Acad. Sci. U.S.A. - 96 (26) : 14925-14930 (PMID: 10611314)
15 Dec | 1999 Simultaneous localization of transcription and early processing markers allows dissection of functional domains in the plant cell nucleolus. de Carcer, G , Medina, FJ. J. Struct. Biol. - 128 (2) : 139-151 (PMID: 10600568) (doi:10.1006/jsbi.1999.4187)
21 May | 1998 Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. Sanchez, P, De Carcer, G , Sandoval, IV, Moscat, J, Diaz-Meco, MT. Mol. Cell. Biol. - 18 (5) : 3069-3080 (PMID: 9566925)
24 Jun | 1997 NopA64, a novel nucleolar phosphoprotein from proliferating onion cells, sharing immunological determinants with mammalian nucleolin. de Cárcer, G , Cerdido, A, Medina, FJ. Planta - 201 (4) : 487-495 (PMID: 9151450) (doi:10.1007/s004250050093)
15 Dec | 1995 Protein 4.1 is a component of the nuclear matrix of mammalian cells. de Cárcer, G , Lallena, MJ, Correas, I. Biochem. J. - 312 ( Pt 3) : 871-877 (PMID: 8554533)