Publications

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All our publications

*Listed are the articles found in the PubMed database.

Publications by “Bruno Sainz Anding”

c-Rel drives pancreatic cancer metastasis through Fibronectin-Integrin signaling-induced isolation stress resistance and EMT activation.

Bakırdöğen, D, Görgülü, K, Xin, J, Alcalá, S, Ruiz-Cañas, L, Frank, K, Wu, N, Diakopoulos, KN, Dai, C, Öztürk, H, Demircioğlu, D, Peschke, K, Ranjan, R, Fusco, F, Martinez-Useros, J, Fernandez-Aceñero, MJ, Chhabra, NF, López-Gil, JC, Ai, J, Ruess, DA, Kaya-Aksoy, E, Steiger, K, Schmidt, F, Kohlmann, L, Berninger, A, Schmid, RM, Reichert, M, Adli, M, Lesina, M, Sainz, B , Algül, H.

Three-dimensional environment sensitizes pancreatic cancer cells to the anti-proliferative effect of budesonide by reprogramming energy metabolism.

Ibello, E, Saracino, F, Delle Cave, D, Buonaiuto, S, Amoroso, F, Andolfi, G, Corona, M, Guardiola, O, Colonna, V, Sainz, B , Altucci, L, De Cesare, D, Cobellis, G, Lonardo, E, Patriarca, EJ, D'Aniello, C, Minchiotti, G.

The Peptidoglycan Recognition Protein 1 confers immune evasive properties on pancreatic cancer stem cells.

López-Gil, JC , García-Silva, S , Ruiz-Cañas, L , Navarro, D , Palencia-Campos, A , Giráldez-Trujillo, A, Earl, J, Dorado, J , Gómez-López, G, Monfort-Vengut, A , Alcalá, S , Gaida, MM, García-Mulero, S, Cabezas-Sáinz, P, Batres-Ramos, S , Barreto, E, Sánchez-Tomero, P , Vallespinós, M, Ambler, L, Lin, ML, Aicher, A, García García de Paredes, A, de la Pinta, C, Sanjuanbenito, A, Ruz-Caracuel, I, Rodríguez-Garrote, M, Guerra, C, Carrato, A, de Cárcer, G , Sánchez, L, Nombela-Arrieta, C, Espinet, E, Sanchez-Arevalo Lobo, VJ, Heeschen, C, Sainz, B .

Targeting cancer stem cell OXPHOS with tailored ruthenium complexes as a new anti-cancer strategy.

Alcalá, S , Villarino, L, Ruiz-Cañas, L , Couceiro, JR, Martínez-Calvo, M, Palencia-Campos, A , Navarro, D , Cabezas-Sainz, P, Rodriguez-Arabaolaza, I , Cordero-Barreal, A , Trilla-Fuertes, L, Rubiolo, JA, Batres-Ramos, S , Vallespinos, M , González-Páramos, C , Rodríguez, J, Gámez-Pozo, A , Vara, JÁF, Fernández, SF, Berlinches, AB, Moreno-Mata, N, Redondo, AMT, Carrato, A, Hermann, PC, Sánchez, L, Torrente, S, Fernández-Moreno, MÁ , Mascareñas, JL, Sainz, B .

Everything you ever wanted to know about cancer stem cells in neuroendocrine neoplasms but were afraid to ask.

Ruz-Caracuel, I, Pedraza-Arevalo, S, Alonso-Gordoa, T, Molina-Cerrillo, J, Earl, J, Sainz, B .

Inhibiting NR5A2 targets stemness in pancreatic cancer by disrupting SOX2/MYC signaling and restoring chemosensitivity.

Zheng, Q, Tang, J, Aicher, A, Bou Kheir, T, Sabanovic, B, Ananthanarayanan, P, Reina, C, Chen, M, Gu, JM, He, B, Alcala, S , Behrens, D, Lawlo, RT, Scarpa, A, Hidalgo, M, Sainz, B , Sancho, P, Heeschen, C.

Splicing alterations in pancreatic ductal adenocarcinoma: a new molecular landscape with translational potential.

Alors-Pérez, E, Pedraza-Arevalo, S, Blázquez-Encinas, R, Moreno-Montilla, MT, García-Vioque, V, Berbel, I, Luque, RM, Sainz, B , Ibáñez-Costa, A, Castaño, JP.

Nanomedicine and epigenetics: New alliances to increase the odds in pancreatic cancer survival.

Urbanova, M, Cihova, M, Buocikova, V, Slopovsky, J, Dubovan, P, Pindak, D, Tomas, M, García-Bermejo, L, Rodríguez-Garrote, M, Earl, J, Kohl, Y, Kataki, A, Dusinska, M, Sainz, B , Smolkova, B, Gabelova, A.

Establishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh Tissue.

Díaz-Alejo, JF, April-Monn, S, Cihova, M, Buocikova, V, Villalón López, J, Urbanova, M, Lechuga, CG, Tomas, M, Dubovan, P, Sánchez, BL, Páez, SC, Sanjuanbenito, A, Lobo, E, Romio de la Heras, E, Guerra, C, de la Pinta, C, Barreto Melian, E, Rodríguez Garrote, M, Carrato, A, Ruiz-Cañas, L , Sainz, B , Torres, A, Smolkova, B, Earl, J.

Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancer.

Frank, KJ, Mulero-Sánchez, A, Berninger, A, Ruiz-Cañas, L , Bosma, A, Görgülü, K, Wu, N, Diakopoulos, KN, Kaya-Aksoy, E, Ruess, DA, Kabacaoğlu, D, Schmidt, F, Kohlmann, L, van Tellingen, O, Thijssen, B, van de Ven, M, Proost, N, Kossatz, S, Weber, WA, Sainz, B , Bernards, R, Algül, H, Lesina, M, Mainardi, S.

LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer.

Cave, DD, Buonaiuto, S, Sainz, B , Fantuz, M, Mangini, M, Carrer, A, Di Domenico, A, Iavazzo, TT, Andolfi, G, Cortina, C, Sevillano, M, Heeschen, C, Colonna, V, Corona, M, Cucciardi, A, Di Guida, M, Batlle, E, De Luca, A, Lonardo, E.

Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma.

Alonso-Nocelo, M , Ruiz-Cañas, L , Sancho, P, Görgülü, K, Alcalá, S , Pedrero, C , Vallespinos, M , López-Gil, JC , Ochando, M , García-García, E, David Trabulo, SM, Martinelli, P, Sánchez-Tomero, P , Sánchez-Palomo, C, Gonzalez-Santamaría, P , Yuste, L , Wörmann, SM, Kabacaoğlu, D, Earl, J, Martin, A , Salvador, F , Valle, S , Martin-Hijano, L , Carrato, A, Erkan, M, García-Bermejo, L, Hermann, PC, Algül, H, Moreno-Bueno, G , Heeschen, C, Portillo, F , Cano, A , Sainz, B .

Targeting BPTF Sensitizes Pancreatic Ductal Adenocarcinoma to Chemotherapy by Repressing ABC-Transporters and Impairing Multidrug Resistance (MDR).

Muñoz Velasco, R, Jiménez Sánchez, P, García García, A, Blanco Martinez-Illescas, R, Pastor Senovilla, Á, Lozano Yagüe, M, Trento, A, García-Martin, RM, Navarro, D , Sainz, B , Rodríguez Peralto, JL, Sánchez-Arévalo Lobo, VJ.

Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug.

Alors-Perez, E, Blázquez-Encinas, R, Alcalá, S , Viyuela-García, C, Pedraza-Arevalo, S, Herrero-Aguayo, V, Jiménez-Vacas, JM, Mafficini, A, Sánchez-Frías, ME, Cano, MT, Abollo-Jiménez, F, Marín-Sanz, JA, Cabezas-Sainz, P, Lawlor, RT, Luchini, C, Sánchez, L, Sánchez-Hidalgo, JM, Ventura, S, Martin-Hijano, L , Gahete, MD, Scarpa, A, Arjona-Sánchez, Á, Ibáñez-Costa, A, Sainz, B , Luque, RM, Castaño, JP.

Correction: Earl et al. Somatic Mutation Profiling in the Liquid Biopsy and Clinical Analysis of Hereditary and Familial Pancreatic Cancer Cases Reveals KRAS Negativity and a Longer Overall Survival. Cancers 2021, 13, 1612.

Earl, J, Barreto, E, Castillo, ME, Fuentes, R, Rodríguez-Garrote, M, Ferreiro, R, Reguera, P, Muñoz, G, Garcia-Seisdedos, D, López, JV, Sainz, B , Malats, N, Carrato, A.

Telomerase and Pluripotency Factors Jointly Regulate Stemness in Pancreatic Cancer Stem Cells.

Walter, K, Rodriguez-Aznar, E, Ferreira, MSV, Frappart, PO, Dittrich, T, Tiwary, K, Meessen, S, Lerma, L, Daiss, N, Schulte, LA, Najafova, Z, Arnold, F, Usachov, V, Azoitei, N, Erkan, M, Lechel, A, Brümmendorf, TH, Seufferlein, T, Kleger, A, Tabarés, E , Günes, C, Johnsen, SA, Beier, F, Sainz, B , Hermann, PC.

Biomarkers Associated with Regorafenib First-Line Treatment Benefits in Metastatic Colorectal Cancer Patients: REFRAME Molecular Study.

Conde, E, Earl, J, Crespo-Toro, L, Blanco-Agudo, C, Ramos-Muñoz, E, Rodríguez-Serrano, EM, Martínez Ávila, JC, Salinas-Muñoz, L, Serrano-Huertas, S, Ferreiro, R, Rodriguez-Garrote, M, Sainz, B , Massuti, B, Alfonso, PG, Benavides, M, Aranda, E, García-Bermejo, ML, Carrato, A.

BCL3 couples cancer stem cell enrichment with pancreatic cancer molecular subtypes.

Ai, J, Wörmann, SM, Görgülü, K, Vallespinos, M , Zagorac, S, Alcala, S , Wu, N, Kabacaoglu, D, Berninger, A, Navarro, D , Kaya-Aksoy, E, Ruess, DA, Ciecielski, KJ, Kowalska, M, Demir, EI, Ceyhan, GO, Heid, I, Braren, R, Riemann, M, Schreiner, S, Hofmann, S, Kutschke, M, Jastroch, M, Slotta-Huspenina, J, Muckenhuber, A, Schlitter, AM, Schmid, RM, Steiger, K, Diakopoulos, KN, Lesina, M, Sainz, B , Algül, H.

Somatic Mutation Profiling in the Liquid Biopsy and Clinical Analysis of Hereditary and Familial Pancreatic Cancer Cases Reveals KRAS Negativity and a Longer Overall Survival.

Earl, J, Barreto, E, Castillo, ME, Fuentes, R, Rodríguez-Garrote, M, Ferreiro, R, Reguera, P, Muñoz, G, Garcia-Seisdedos, D, López, JV, Sainz, B , Malats, N, Carrato, A.

Inhibition of Mitochondrial Dynamics Preferentially Targets Pancreatic Cancer Cells with Enhanced Tumorigenic and Invasive Potential.

Courtois, S, de Luxán-Delgado, B, Penin-Peyta, L, Royo-García, A, Parejo-Alonso, B, Jagust, P, Alcalá, S , Rubiolo, JA, Sánchez, L, Sainz, B , Heeschen, C, Sancho, P.

Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells.

Valle, S , Alcalá, S , Martin-Hijano, L , Cabezas-Sáinz, P, Navarro, D , Muñoz, ER, Yuste, L , Tiwary, K, Walter, K, Ruiz-Cañas, L , Alonso-Nocelo, M , Rubiolo, JA, González-Arnay, E, Heeschen, C, Garcia-Bermejo, L, Hermann, PC, Sánchez, L, Sancho, P, Fernández-Moreno, MÁ , Sainz, B .

Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer.

Gout, J, Perkhofer, L, Morawe, M, Arnold, F, Ihle, M, Biber, S, Lange, S, Roger, E, Kraus, JM, Stifter, K, Hahn, SA, Zamperone, A, Engleitner, T, Müller, M, Walter, K, Rodriguez-Aznar, E, Sainz, B , Hermann, PC, Hessmann, E, Müller, S, Azoitei, N, Lechel, A, Liebau, S, Wagner, M, Simeone, DM, Kestler, HA, Seufferlein, T, Wiesmüller, L, Rad, R, Frappart, PO, Kleger, A.

Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells.

Cash, TP, Alcalá, S , Rico-Ferreira, MDR, Hernández-Encinas, E, García, J, Albarrán, MI, Valle, S , Muñoz, J, Martínez-González, S, Blanco-Aparicio, C, Pastor, J, Serrano, M, Sainz, B .

Pancreatic cancer-derived organoids - a disease modeling tool to predict drug response.

Frappart, PO, Walter, K, Gout, J, Beutel, AK, Morawe, M, Arnold, F, Breunig, M, Barth, TF, Marienfeld, R, Schulte, L, Ettrich, T, Hackert, T, Svinarenko, M, Rösler, R, Wiese, S, Wiese, H, Perkhofer, L, Müller, M, Lechel, A, Sainz, B , Hermann, PC, Seufferlein, T, Kleger, A.

MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo.

Walter, K, Tiwary, K, Trajkovic-Arsic, M, Hidalgo-Sastre, A, Dierichs, L, Liffers, ST, Gu, J, Gout, J, Schulte, LA, Münch, J, Seufferlein, T, Sainz, B , Siveke, JT, Rodriguez-Aznar, E, Hermann, PC.

Pathogenic variants in glutamyl-tRNAGln amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder.

Friederich, MW, Timal, S, Powell, CA, Dallabona, C, Kurolap, A, Palacios-Zambrano, S , Bratkovic, D, Derks, TGJ, Bick, D, Bouman, K, Chatfield, KC, Damouny-Naoum, N, Dishop, MK, Falik-Zaccai, TC, Fares, F, Fedida, A, Ferrero, I, Gallagher, RC, Garesse, R , Gilberti, M, González, C , Gowan, K, Habib, C, Halligan, RK, Kalfon, L, Knight, K, Lefeber, D, Mamblona, L , Mandel, H, Mory, A, Ottoson, J, Paperna, T, Pruijn, GJM, Rebelo-Guiomar, PF, Saada, A, Sainz, B , Salvemini, H, Schoots, MH, Smeitink, JA, Szukszto, MJ, Ter Horst, HJ, van den Brandt, F, van Spronsen, FJ, Veltman, JA, Wartchow, E, Wintjes, LT, Zohar, Y, Fernández-Moreno, MA , Baris, HN, Donnini, C, Minczuk, M, Rodenburg, RJ, Van Hove, JLK.

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.

Ruess, DA, Heynen, GJ, Ciecielski, KJ, Ai, J, Berninger, A, Kabacaoglu, D, Görgülü, K, Dantes, Z, Wörmann, SM, Diakopoulos, KN, Karpathaki, AF, Kowalska, M, Kaya-Aksoy, E, Song, L, van der Laan, EAZ, López-Alberca, MP, Nazaré, M, Reichert, M, Saur, D, Erkan, MM, Hopt, UT, Sainz, B , Birchmeier, W, Schmid, RM, Lesina, M, Algül, H.

Current perspectives on the crosstalk between lung cancer stem cells and cancer-associated fibroblasts.

Alguacil-Núñez, C, Ferrer-Ortiz, I, García-Verdú, E, López-Pirez, P, Llorente-Cortijo, IM, Sainz, B .

A Label Free Disposable Device for Rapid Isolation of Rare Tumor Cells from Blood by Ultrasounds.

González, I, Earl, J, Fernández, LJ, Sainz, B , Pinto, A, Monge, R, Alcalá, S , Castillejo, A, Soto, JL, Carrato, A.

Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors.

Djurec, M, Graña, O, Lee, A, Troulé, K, Espinet, E, Cabras, L, Navas, C, Blasco, MT, Martín-Díaz, L, Burdiel, M, Li, J, Liu, Z, Vallespinós, M, Sanchez-Bueno, F, Sprick, MR, Trumpp, A, Sainz, B , Al-Shahrour, F, Rabadan, R, Guerra, C, Barbacid, M.

Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling.

Hohwieler, M, Illing, A, Hermann, PC, Mayer, T, Stockmann, M, Perkhofer, L, Eiseler, T, Antony, JS, Müller, M, Renz, S, Kuo, CC, Lin, Q, Sendler, M, Breunig, M, Kleiderman, SM, Lechel, A, Zenker, M, Leichsenring, M, Rosendahl, J, Zenke, M, Sainz, B , Mayerle, J, Costa, IG, Seufferlein, T, Kormann, M, Wagner, M, Liebau, S, Kleger, A.

GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer.

Martinelli, P, Carrillo-de Santa Pau, E, Cox, T, Sainz, B , Dusetti, N, Greenhalf, W, Rinaldi, L, Costello, E, Ghaneh, P, Malats, N, Büchler, M, Pajic, M, Biankin, AV, Iovanna, J, Neoptolemos, J, Real, FX.

Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment.

Sainz, B , Alcala, S , Garcia, E, Sanchez-Ripoll, Y, Azevedo, MM, Cioffi, M, Tatari, M, Miranda-Lorenzo, I, Hidalgo, M, Gomez-Lopez, G, Cañamero, M, Erkan, M, Kleeff, J, García-Silva, S , Sancho, P, Hermann, PC, Heeschen, C.

The miR-17-92 cluster counteracts quiescence and chemoresistance in a distinct subpopulation of pancreatic cancer stem cells.

Cioffi, M, Trabulo, SM, Sanchez-Ripoll, Y, Miranda-Lorenzo, I, Lonardo, E, Dorado, J , Reis Vieira, C, Ramirez, JC, Hidalgo, M, Aicher, A, Hahn, S, Sainz, B , Heeschen, C.

Expression of the immediate early IE180 protein under the control of the hTERT and CEA tumor-specific promoters in recombinant pseudorabies viruses: Effects of IE180 protein on promoter activity and apoptosis induction.

Lerma, L, Alcalá, S, Piñero, C, Torres, M, Martin, B, Lim, F, Sainz, B , Tabarés, E.

MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells.

Sancho, P, Burgos-Ramos, E, Tavera, A, Bou Kheir, T, Jagust, P, Schoenhals, M, Barneda, D, Sellers, K, Campos-Olivas, R, Graña, O, Viera, CR, Yuneva, M, Sainz, B , Heeschen, C.

Intracellular autofluorescence: a biomarker for epithelial cancer stem cells.

Miranda-Lorenzo, I, Dorado, J , Lonardo, E, Alcala, S , Serrano, AG, Clausell-Tormos, J, Cioffi, M, Megias, D, Zagorac, S, Balic, A, Hidalgo, M, Erkan, M, Kleeff, J, Scarpa, A, Sainz, B , Heeschen, C.

Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.

Hermann, PC, Sancho, P, Cañamero, M, Martinelli, P, Madriles, F, Michl, P, Gress, T, de Pascual, R, Gandia, L, Guerra, C, Barbacid, M, Wagner, M, Vieira, CR, Aicher, A, Real, FX, Sainz, B , Heeschen, C.

Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling.

Balic, A, Sørensen, MD, Trabulo, SM, Sainz, B , Cioffi, M, Vieira, CR, Miranda-Lorenzo, I, Hidalgo, M, Kleeff, J, Erkan, M, Heeschen, C.

Determining the involvement and therapeutic implications of host cellular factors in hepatitis C virus cell-to-cell spread.

Barretto, N, Sainz, B , Hussain, S, Uprichard, SL.

Differential induction of apoptosis, interferon signaling, and phagocytosis in macrophages infected with a panel of attenuated and nonattenuated poxviruses.

Royo, S, Sainz, B , Hernández-Jiménez, E, Reyburn, H, López-Collazo, E, Guerra, S.

Multimodal Treatment Eliminates Cancer Stem Cells and Leads to Long-Term Survival in Primary Human Pancreatic Cancer Tissue Xenografts.

Hermann, PC, Trabulo, SM, Sainz, B , Balic, A, Garcia, E, Hahn, SA, Vandana, M, Sahoo, SK, Tunici, P, Bakker, A, Hidalgo, M, Heeschen, C.

Identification of hepatitis C virus inhibitors targeting different aspects of infection using a cell-based assay.

Yu, X, Sainz, B , Petukhov, PA, Uprichard, SL.

Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor.

Sainz, B , Barretto, N, Martin, DN, Hiraga, N, Imamura, M, Hussain, S, Marsh, KA, Yu, X, Chayama, K, Alrefai, WA, Uprichard, SL.

Development of a cell-based hepatitis C virus infection fluorescent resonance energy transfer assay for high-throughput antiviral compound screening.

Yu, X, Sainz, B , Uprichard, SL.

Effects of once versus twice-daily parathyroid hormone 1-34 therapy in children with hypoparathyroidism.

Winer, KK, Sinaii, N, Peterson, D, Sainz, B , Cutler, GB.

Anti-20S proteasome antibodies in psoriatic arthritis.

Colmegna, I, Sainz, B , Citera, G, Maldonado-Cocco, JA, Garry, RF, Espinoza, LR.

Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein.

Sainz, B , Mossel, EC, Gallaher, WR, Wimley, WC, Peters, CJ, Wilson, RB, Garry, RF.

The proteasome and its implications in rheumatology.

Colmegna, I, Sainz, B , Garry, RF, Espinoza, LR.

The aromatic domain of the coronavirus class I viral fusion protein induces membrane permeabilization: putative role during viral entry.

Sainz, B , Rausch, JM, Gallaher, WR, Garry, RF, Wimley, WC.

Alpha/Beta interferon and gamma interferon synergize to inhibit the replication of herpes simplex virus type 1.

Sainz, B , Halford, WP.

Effect of famciclovir on herpes simplex virus type 1 corneal disease and establishment of latency in rabbits.

Loutsch, JM, Sainz, B , Marquart, ME, Zheng, X, Kesavan, P, Higaki, S, Hill, JM, Tal-Singer, R.

HSV-1 migration in latently infected and naive rabbits after penetrating keratoplasty.

Zheng, X, Marquart, ME, Loustch, JM, Shah, P, Sainz, B , Ray, A, O'Callaghan, RJ, Kaufman, HE, Hill, JM.
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