1 Jul | 2024 DUSP1 and SOX2 expression determine squamous cell carcinoma of the salivary gland progression. Acero-Riaguas, L , Griso-Acevedo, AB, SanLorenzo-Vaquero, A, Ibáñez-Herrera, B, Fernandez-Diaz, SM, Mascaraque, M, Sánchez-Siles, R, López-García, I, Benítez-Buelga, C , Bravo-Burguillos, ER, Castelo, B, Cebrián-Carretero, JL, Perona, R , Sastre, L , Sastre-Perona, A . Sci Rep - 14 (1) : 15007 (PMID: 38951654) (doi:10.1038/s41598-024-65945-x)
18 Apr | 2024 Clinical mutations in the TERT and TERC genes coding for telomerase components induced oxidative stress, DNA damage at telomeres and cell apoptosis besides decreased telomerase activity. Fernández-Varas, B , Manguan-García, C , Rodriguez-Centeno, J , Mendoza-Lupiáñez, L , Calatayud, J, Perona, R , Martín-Martínez, M, Gutierrez-Rodriguez, M, Benítez-Buelga, C , Sastre, L . Hum Mol Genet - 33 (9) : 818-834 (PMID: 38641551) (doi:10.1093/hmg/ddae015)
6 Apr | 2023 Gene therapy restores the transcriptional program of hematopoietic stem cells in Fanconi anemia. Lasaga, M, Río, P, Vilas-Zornoza, A, Planell, N, Navarro, S, Alignani, D, Fernández-Varas, B , Mouzo, D, Zubicaray, J, Pujol, RM, Nicoletti, E, Schwartz, JD, Sevilla, J, Ainciburi, M, Ullate-Agote, A, Surrallés, J, Perona, R , Sastre, L , Prosper, F, Gomez-Cabrero, D, Bueren, JA. Haematologica (PMID: 37021532) (doi:10.3324/haematol.2022.282418)
22 Aug | 2022 Shorter telomere length is associated with COVID-19 hospitalization and with persistence of radiographic lung abnormalities. Retuerto, M, Lledó, A, Fernandez-Varas, B , Guerrero-López, R , Usategui, A, Lalueza, A, García-García, R, Mancebo, E, Paz-Artal, E, Sastre, L , Perona, R , Pablos, JL. Immun Ageing - 19 (1) : 38 (PMID: 35996190) (doi:10.1186/s12979-022-00294-9)
1 Feb | 2022 Comparison of Colorectal Cancer Stem Cells and Oxaliplatin-Resistant Cells Unveils Functional Similarities. Rodríguez-Fanjul, V , Guerrero-López, R , Fernández-Varas, B , Perona, R , Sastre-Perona, A , Sastre, L . Cells - 11 (3) (PMID: 35159320) (doi:10.3390/cells11030511)
1 Apr | 2021 Next-generation Sequencing in Bone Marrow Failure Syndromes and Isolated Cytopenias: Experience of the Spanish Network on Bone Marrow Failure Syndromes. Gálvez, E, Vallespín, E, Arias-Salgado, EG , Sánchez-Valdepeñas, C, Giménez, Y, Navarro, S, Río, P, Bogliolo, M, Pujol, R, Peiró, M, Nevado, J , Zubicaray, J, Sebastián, E, Catalá, A, Beléndez, C, Díaz de Heredia, C, Galera, A, Badell, I, Madero, L, Perona, R , Sastre, L , Surrallés, J, Bueren, J, Lapunzina, P, Sevilla, J. Hemasphere - 5 (4) : e539 (PMID: 33718801) (doi:10.1097/HS9.0000000000000539)
1 Mar | 2021 GSE4-loaded nanoparticles a potential therapy for lung fibrosis that enhances pneumocyte growth, reduces apoptosis and DNA damage. Pintado-Berninches, L , Montes-Worboys, A, Manguan-García, C , Arias-Salgado, EG , Serrano, A, Fernandez-Varas, B , Guerrero-López, R , Iarriccio, L , Planas, L, Guenechea, G, Egusquiaguirre, SP, Hernandez, RM, Igartua, M, Luis Pedraz, J, Cortijo, J, Sastre, L , Molina-Molina, M, Perona, R . FASEB J - 35 (3) : e21422 (PMID: 33638895) (doi:10.1096/fj.202001160RR)
29 Jan | 2021 Generation of dyskeratosis congenita-like hematopoietic stem cells through the stable inhibition of DKC1. Carrascoso-Rubio, C , Zittersteijn, HA, Pintado-Berninches, L , Fernández-Varas, B , Lozano, ML, Manguan-Garcia, C , Sastre, L , Bueren, JA, Perona, R , Guenechea, G. Stem Cell Res Ther - 12 (1) : 92 (PMID: 33514435) (doi:10.1186/s13287-021-02145-8)
8 Nov | 2019 Dyskerin Mutations Present in Dyskeratosis Congenita Patients Increase Oxidative Stress and DNA Damage Signalling in Dictyostelium Discoideum. Rodriguez-Centeno, J , Perona, R , Sastre, L . Cells - 8 (11) (PMID: 31717312) (doi:10.3390/cells8111406)
24 Sep | 2019 Structure of Dictyostelium discoideum telomeres. Analysis of possible replication mechanisms. Rodriguez-Centeno, J , Manguán-García, C , Perona, R , Sastre, L . PLoS ONE - 14 (9) : e0222909 (PMID: 31550289) (doi:10.1371/journal.pone.0222909)
25 Apr | 2019 Role of Dusp6 Phosphatase as a Tumor Suppressor in Non-Small Cell Lung Cancer. Moncho-Amor, V , Pintado-Berninches, L , Ibañez de Cáceres, I, Martín-Villar, E , Quintanilla, M , Chakravarty, P, Cortes-Sempere, M , Fernández-Varas, B , Rodriguez-Antolín, C, de Castro, J, Sastre, L , Perona, R . Int J Mol Sci - 20 (8) (PMID: 31027181) (doi:10.3390/ijms20082036)
17 Apr | 2019 Genetic analyses of aplastic anemia and idiopathic pulmonary fibrosis patients with short telomeres, possible implication of DNA-repair genes. Arias-Salgado, EG , Galvez, E, Planas-Cerezales, L, Pintado-Berninches, L , Vallespin, E, Martinez, P, Carrillo, J , Iarriccio, L , Ruiz-Llobet, A, Catalá, A, Badell-Serra, I, Gonzalez-Granado, LI, Martín-Nalda, A, Martínez-Gallo, M, Galera-Miñarro, A, Rodríguez-Vigil, C, Bastos-Oreiro, M, Perez de Nanclares, G, Leiro-Fernández, V, Uria, ML, Diaz-Heredia, C, Valenzuela, C, Martín, S, López-Muñiz, B, Lapunzina, P, Sevilla, J, Molina-Molina, M, Perona, R , Sastre, L . Orphanet J Rare Dis - 14 (1) : 82 (PMID: 30995915) (doi:10.1186/s13023-019-1046-0)
22 Jan | 2019 GSE4 peptide suppresses oxidative and telomere deficiencies in ataxia telangiectasia patient cells. Pintado-Berninches, L , Fernandez-Varas, B , Benitez-Buelga, C, Manguan-Garcia, C , Serrano-Benitez, A, Iarriccio, L , Carrillo, J , Guenechea, G, Egusquiaguirre, SP, Pedraz, JL, Hernández, RM, Igartua, M, Arias-Salgado, EG , Cortés-Ledesma, F, Sastre, L , Perona, R . Cell Death Differ. (PMID: 30670828) (doi:10.1038/s41418-018-0272-7)
24 Mar | 2017 Mutations in xlf/nhej1/cernunnos Gene Results In Downregulation of Telomerase Genes Expression and Telomere Shortening. Carrillo, J , Calvete, O, Pintado Berninches, L, Manguan-García, C , Sevilla Navarro, J, Arias-Salgado, EG , Sastre, L , Guenechea, G, López Granados, E, de Villartay, JP, Revy, P, Benitez, J, Perona, R . Hum. Mol. Genet. (PMID: 28369633) (doi:10.1093/hmg/ddx098)
3 Feb | 2016 Biological Activity of the Alternative Promoters of the Dictyostelium discoideum Adenylyl Cyclase A Gene. Rodriguez-Centeno, J , Sastre, L . PLoS ONE - 11 (2) : e0148533 (PMID: 26840347) (doi:10.1371/journal.pone.0148533)
16 Nov | 2015 GSE4, a Small Dyskerin- and GSE24.2-Related Peptide, Induces Telomerase Activity, Cell Proliferation and Reduces DNA Damage, Oxidative Stress and Cell Senescence in Dyskerin Mutant Cells. Iarriccio, L , Manguán-García, C , Pintado-Berninches, L , Mancheño, JM, Molina, A, Perona, R , Sastre, L . PLoS ONE - 10 (11) : e0142980 (PMID: 26571381) (doi:10.1371/journal.pone.0142980)
1 Mar | 2015 Biomarkers of erlotinib response in non-small cell lung cancer tumors that do not harbor the more common epidermal growth factor receptor mutations. López-Ayllón, BD, de Castro-Carpeño, J, Rodriguez, C, Pernía, O, Ibañez de Cáceres, I, Belda-Iniesta, C , Perona, R , Sastre, L . Int J Clin Exp Pathol - 8 (3) : 2888-2898 (PMID: 26045797)
20 Oct | 2014 Cancer stem cells and cisplatin-resistant cells isolated from non-small-lung cancer cell lines constitute related cell populations. Lopez-Ayllon, BD, Moncho-Amor, V, Abarrategi, A, Ibañez de Cáceres, I, Castro-Carpeño, J, Belda-Iniesta, C , Perona, R , Sastre, L . Cancer Med - 3 (5) : 1099-1111 (PMID: 24961511) (doi:10.1002/cam4.291)
2 Jul | 2014 Expression of the genetic suppressor element 24.2 (GSE24.2) decreases DNA damage and oxidative stress in X-linked dyskeratosis congenita cells. Manguan-Garcia, C , Pintado-Berninches, L , Carrillo, J , Machado-Pinilla, R , Sastre, L , Pérez-Quilis, C, Esmoris, I, Gimeno, A, García-Giménez, JL, Pallardó, FV, Perona, R . PLoS ONE - 9 (7) : e101424 (PMID: 24987982) (doi:10.1371/journal.pone.0101424)
11 Apr | 2013 Mef2A, a homologue of animal Mef2 transcription factors, regulates cell differentiation in Dictyostelium discoideum. Galardi-Castilla, M , Fernandez-Aguado, I, Suarez, T, Sastre, L . BMC Dev. Biol. - 13 : 12 (PMID: 23577638) (doi:10.1186/1471-213X-13-12)
11 Oct | 2012 Defects in mTR stability and telomerase activity produced by the Dkc1 A353V mutation in dyskeratosis congenita are rescued by a peptide from the dyskerin TruB domain. Machado-Pinilla, R , Carrillo, J , Manguan-Garcia, C , Sastre, L , Mentzer, A, Gu, BW, Mason, PJ, Perona, R . Clin Transl Oncol - 14 (10) : 755-763 (PMID: 22855157) (doi:10.1007/s12094-012-0865-4)
2 Jun | 2012 High resolution melting analysis for the identification of novel mutations in DKC1 and TERT genes in patients with dyskeratosis congenita. Carrillo, J , Martínez, P, Solera, J, Moratilla, C , González, A, Manguán-García, C , Aymerich, M, Canal, L, Del Campo, M, Dapena, JL, Escoda, L, García-Sagredo, JM, Martín-Sala, S, Rives, S, Sevilla, J, Sastre, L , Perona, R . Blood Cells Mol. Dis. - 49 (3-4) : 140-146 (PMID: 22664374) (doi:10.1016/j.bcmd.2012.05.008)
20 May | 2011 New DNA sequencing technologies open a promising era for cancer research and treatment. Sastre, L . Clin Transl Oncol - 13 (5) : 301-306 (PMID: 21596657) (doi:10.1007/s12094-011-0658-1)
18 Mar | 2011 The dual-specificity protein phosphatase MkpB, homologous to mammalian MKP phosphatases, is required for D. discoideum post-aggregative development and cisplatin response. Moncho-Amor, V , Galardi-Castilla, M , Perona, R , Sastre, L . Differentiation - 81 (3) : 199-207 (PMID: 21300429) (doi:10.1016/j.diff.2011.01.004)
11 Oct | 2010 The Dictyostelium discoideum acaA gene is transcribed from alternative promoters during aggregation and multicellular development. Galardi-Castilla, M , Garciandía, A, Suarez, T, Sastre, L . PLoS ONE - 5 (10) : e13286 (PMID: 20949015) (doi:10.1371/journal.pone.0013286)
15 Apr | 2008 SrfB, a member of the Serum Response Factor family of transcription factors, regulates starvation response and early development in Dictyostelium. Galardi-Castilla, M , Pergolizzi, B, Bloomfield, G, Skelton, J, Ivens, A, Kay, RR, Bozzaro, S, Sastre, L . Dev. Biol. - 316 (2) : 260-274 (PMID: 18339368) (doi:10.1016/j.ydbio.2008.01.026)
1 Mar | 2008 A dyskerin motif reactivates telomerase activity in X-linked dyskeratosis congenita and in telomerase-deficient human cells. Machado-Pinilla, R , Sánchez-Pérez, I , Murguía, JR , Sastre, L , Perona, R . Blood - 111 (5) : 2606-2614 (PMID: 18057229) (doi:10.1182/blood-2007-04-083261)
3 Jan | 2008 Structural and functional studies of a family of Dictyostelium discoideum developmentally regulated, prestalk genes coding for small proteins. Vicente, JJ , Galardi-Castilla, M , Escalante, R , Sastre, L . BMC Microbiol. - 8 : 1 (PMID: 18173832) (doi:10.1186/1471-2180-8-1)
10 Jul | 2007 Role of SP65 in assembly of the Dictyostelium discoideum spore coat. Metcalf, T, van der Wel, H, Escalante, R , Sastre, L , West, CM. Eukaryotic Cell - 6 (7) : 1137-1149 (PMID: 17416892) (doi:10.1128/EC.00329-06)
10 Jan | 2007 Molecular systematics of dictyostelids: 5.8S ribosomal DNA and internal transcribed spacer region analyses. Romeralo, M, Escalante, R , Sastre, L , Lado, C. Eukaryotic Cell - 6 (1) : 110-116 (PMID: 17056743) (doi:10.1128/EC.00233-06)
10 Oct | 2006 Investigating gene expression: in situ hybridization and reporter genes. Escalante, R , Sastre, L . Methods Mol. Biol. - 346 : 247-260 (PMID: 16957295) (doi:10.1385/1-59745-144-4:247)
15 Mar | 2006 Functional genomics in Dictyostelium: MidA, a new conserved protein, is required for mitochondrial function and development. Torija, P , Vicente, JJ , Rodrigues, TB , Robles, A , Cerdán, S , Sastre, L , Calvo, RM , Escalante, R . J. Cell. Sci. - 119 (Pt 6) : 1154-1164 (PMID: 16507593) (doi:10.1242/jcs.02819)
12 Apr | 2004 Identification of genes dependent on the MADS box transcription factor SrfA in Dictyostelium discoideum development. Escalante, R , Iranfar, N, Sastre, L , Loomis, WF. Eukaryotic Cell - 3 (2) : 564-566 (PMID: 15075287)
1 Mar | 2004 Overexpression of the multidrug efflux pump SmeDEF impairs Stenotrophomonas maltophilia physiology. Alonso, A, Morales, G, Escalante, R , Campanario, E, Sastre, L , Martinez, JL. J. Antimicrob. Chemother. - 53 (3) : 432-434 (PMID: 14739147) (doi:10.1093/jac/dkh074)
6 Jan | 2004 The MADS-box transcription factor SrfA is required for actin cytoskeleton organization and spore coat stability during Dictyostelium sporulation. Escalante, R , Yamada, Y, Cotter, D, Sastre, L , Sameshima, M. Mech. Dev. - 121 (1) : 51-56 (PMID: 14706699)
10 Dec | 2003 Dictyostelium discoideum developmentally regulated genes whose expression is dependent on MADS box transcription factor SrfA. Escalante, R , Moreno, N, Sastre, L . Eukaryotic Cell - 2 (6) : 1327-1335 (PMID: 14665466)
1 May | 2003 Regulation of promoter occupancy during activation of cryptobiotic embryos from the crustacean Artemia franciscana. Martinez-Lamparero, A , Casero, MC , Ortiz-Caro, J , Sastre, L . J. Exp. Biol. - 206 (Pt 9) : 1565-1573 (PMID: 12654895)
2 Sep | 2002 Regulated expression of the MADS-box transcription factor SrfA mediates activation of gene expression by protein kinase A during Dictyostelium sporulation. Escalante, R , Sastre, L . Mech. Dev. - 117 (1-2) : 201-208 (PMID: 12204259)
2 Aug | 2002 Transactivation domains are not functionally conserved between vertebrate and invertebrate serum response factors. Avila, S , Casero, MC , Fernandez-Cantón, R , Sastre, L . Eur. J. Biochem. - 269 (15) : 3669-3677 (PMID: 12153563)
20 Jul | 2001 cAMP and DIF-1 repress the expression of the Dictyostelium MADS-box gene srfA at early stages of development. Escalante, R , Sastre, L . Biochem. Biophys. Res. Commun. - 285 (3) : 820-824 (PMID: 11453666) (doi:10.1006/bbrc.2001.5235)
15 Jul | 2001 The MADS-box gene srfA is expressed in a complex pattern under the control of alternative promoters and is essential for different aspects of Dictyostelium development. Escalante, R , Vicente, JJ , Moreno, N, Sastre, L . Dev. Biol. - 235 (2) : 314-329 (PMID: 11437439) (doi:10.1006/dbio.2001.0303)
1 May | 2001 Characterization of a functional serum response element in the Actin403 gene promoter from the crustacean Artemia franciscana. Casero, MC , Sastre, L . Eur. J. Biochem. - 268 (9) : 2587-2592 (PMID: 11322877)
1 Sep | 2000 A serum response factor homologue is expressed in ectodermal tissues during development of the crustacean Artemia franciscana. Casero, MC , Sastre, L . Mech. Dev. - 96 (2) : 229-232 (PMID: 10960789)
1 Feb | 2000 High DNA sequence variability at the alpha 1 Na/K-ATPase locus of Artemia franciscana (brine shrimp): polymorphism in a gene for salt-resistance in a salt-resistant organism. Sáez, AG, Escalante, R , Sastre, L . Mol. Biol. Evol. - 17 (2) : 235-250 (PMID: 10677846)
9 Jun | 1999 Isolation and characterization of the gene coding for Artemia franciscana TATA-binding protein: expression in cryptobiotic and developing embryos. Sastre, L . Biochim. Biophys. Acta - 1445 (3) : 271-282 (PMID: 10366711)
1 Oct | 1998 A Serum Response Factor homolog is required for spore differentiation in Dictyostelium. Escalante, R , Sastre, L . Development - 125 (19) : 3801-3808 (PMID: 9729488)
15 Jan | 1997 Polymorphism and structure of the gene coding for the alpha 1 subunit of the Artemia franciscana Na/K-ATPase. García-Sáez, A, Perona, R , Sastre, L . Biochem. J. - 321 ( Pt 2) : 509-518 (PMID: 9020888)
1 Nov | 1996 Transcriptional regulation during the activation and development of Artemia franciscana encysted embryos. Martinez-Lamparero, A , Casero, MC , Ortiz-Caro, J , Sastre, L . Int. J. Dev. Biol. - Suppl 1 : 91S-92S (PMID: 9087711)
1 Sep | 1996 Actin gene structure in two Artemia species, A. franciscana and A. parthenogenetica. Ortega, MA, Díaz-Guerra, M , Sastre, L . J. Mol. Evol. - 43 (3) : 224-235 (PMID: 8703088)
1 Apr | 1996 Tissue-specific expression of two Artemia franciscana sarco/endoplasmic reticulum Ca-ATPase isoforms. Escalante, R , Sastre, L . J. Histochem. Cytochem. - 44 (4) : 321-325 (PMID: 8601691)
1 Oct | 1995 Tissue-specific alternative promoters regulate the expression of the two sarco/endoplasmic reticulum Ca-ATPase isoforms from Artemia franciscana. Escalante, R , Sastre, L . DNA Cell Biol. - 14 (10) : 893-900 (PMID: 7546295)
26 Apr | 1995 In situ hybridization analyses of Na, K-ATPase alpha-subunit expression during early larval development of Artemia franciscana. Escalante, R , García-Sáez, A, Sastre, L . J. Histochem. Cytochem. - 43 (4) : 391-399 (PMID: 7897181)
14 Feb | 1995 Gene expression after resumption of development of Artemia franciscana cryptobiotic embryos. Escalante, R , García-Sáez, A, Ortega, MA, Sastre, L . Biochem. Cell Biol. - 72 (3-4) : 78-83 (PMID: 7818853)
18 Nov | 1994 Identification of an Artemia franciscana retropseudogene containing part of the last exons of the sarco/endoplasmic reticulum Ca-ATPase-encoding SERCA gene. Escalante, R , Sastre, L . Gene - 149 (2) : 377-378 (PMID: 7959022)
29 Apr | 1994 Structure of Artemia franciscana sarco/endoplasmic reticulum Ca-ATPase gene. Escalante, R , Sastre, L . J. Biol. Chem. - 269 (17) : 13005-13012 (PMID: 8175720)
5 Jul | 1993 Similar alternative splicing events generate two sarcoplasmic or endoplasmic reticulum Ca-ATPase isoforms in the crustacean Artemia franciscana and in vertebrates. Escalante, R , Sastre, L . J. Biol. Chem. - 268 (19) : 14090-14095 (PMID: 8314776)
15 Sep | 1991 Cloning of a cDNA encoding an Artemia franciscana Na/K ATPase alpha-subunit. Macías, MT , Palmero, I , Sastre, L . Gene - 105 (2) : 197-204 (PMID: 1657719)
11 Sep | 1990 Molecular cloning and expression of four actin isoforms during Artemia development. Macias, MT , Sastre, L . Nucleic Acids Res. - 18 (17) : 5219-5225 (PMID: 2402445)
20 Dec | 1989 Complementary DNA cloning of a protein highly homologous to mammalian sarcoplasmic reticulum Ca-ATPase from the crustacean Artemia. Palmero, I , Sastre, L . J. Mol. Biol. - 210 (4) : 737-748 (PMID: 2533270)
31 Jul | 1989 Differential expression of a gene highly homologous to c-ras during the development of the brine shrimp Artemia. Díaz-Guerra, M , Quintanilla, M , Palmero, I , Sastre, L , Renart, J . Biochem. Biophys. Res. Commun. - 162 (2) : 802-808 (PMID: 2502981)
7 Sep | 1988 Isolation of cDNA clones coding for mitochondrial 16S ribosomal RNA from the crustacean Artemia. Palmero, I , Renart, J , Sastre, L . Gene - 68 (2) : 239-248 (PMID: 3220256)
1 Aug | 1986 A partial genomic DNA clone for the alpha subunit of the mouse complement receptor type 3 and cellular adhesion molecule Mac-1. Sastre, L , Roman, JM, Teplow, DB, Dreyer, WJ, Gee, CE, Larson, RS, Roberts, TM, Springer, TA. Proc. Natl. Acad. Sci. U.S.A. - 83 (15) : 5644-5648 (PMID: 2942940)
1 Aug | 1986 The mouse leukocyte adhesion proteins Mac-1 and LFA-1: studies on mRNA translation and protein glycosylation with emphasis on Mac-1. Sastre, L , Kishimoto, TK, Gee, C, Roberts, T, Springer, TA. J. Immunol. - 137 (3) : 1060-1065 (PMID: 3522736)
1 Jul | 1986 Differentiation of myeloid cells is accompanied by increased levels of pp60c-src protein and kinase activity. Gee, CE, Griffin, J, Sastre, L , Miller, LJ, Springer, TA, Piwnica-Worms, H, Roberts, TM. Proc. Natl. Acad. Sci. U.S.A. - 83 (14) : 5131-5135 (PMID: 2425362)
1 Feb | 1985 Purification and subunit structure of RNA polymerases I and II from Dictyostelium discoideum vegetative cells. Renart, MF , Sastre, L , Díaz, V, Sebastián, J. Mol. Cell. Biochem. - 66 (1) : 21-29 (PMID: 3982401)
1 Sep | 1983 Developmental changes in poly(A) polymerase activity in Artemia. Sastre, L , Sebastián, J. Eur. J. Biochem. - 135 (1) : 69-74 (PMID: 6309518)
29 Oct | 1982 In vitro polyadenylation of messenger ribonucleoprotein particles stored in Artemia dormant embryos. Sastre, L , Sebastián, J. Biochem. Biophys. Res. Commun. - 108 (4) : 1609-1613 (PMID: 6129848)