19 Feb | 2025 Premature ageing of lung alveoli and bone marrow cells from Terc deficient mice with different telomere lengths. Guerrero-López, R , Manguán-García, C , Carrascoso-Rubio, C , Lozano, ML, Toldos-Torres, M, García-Castro, L, Sánchez-Dominguez, R, Alberquilla, O, Sánchez-Pérez, I , Molina-Molina, M, Bueren, JA, Guenechea, G, Perona, R , Sastre, L . Sci Rep - 15 (1) : 6102 (PMID: 39971959) (doi:10.1038/s41598-025-90246-2)
23 Oct | 2024 A select thiosemicarbazone copper(II) complex induces apoptosis in gastric cancer and targets cancer stem cells reducing pluripotency markers. Fabra, D, Melones-Herrero, J , Velazquez-Gutierrez, J, Matesanz, AI, Aliseda, PD, Figueiras, S, Aguilar-Rico, F, Calés, C , Sánchez-Pérez, I , Quiroga, AG. Eur J Med Chem - 280 : 116994 (PMID: 39489985) (doi:10.1016/j.ejmech.2024.116994)
15 Jul | 2024 Trans-[Pt(amine)Cl2(PPh3)] Complexes Target Mitochondria and Endoplasmic Reticulum in Gastric Cancer Cells. Melones-Herrero, J , Delgado-Aliseda, P , Figueiras, S , Velázquez-Gutiérrez, J , Quiroga, AG, Calés, C , Sánchez-Pérez, I . Int J Mol Sci - 25 (14) (PMID: 39062981) (doi:10.3390/ijms25147739)
5 Jul | 2024 SARS-CoV-2 S Protein Reduces Cytoprotective Defenses and Promotes Human Endothelial Cell Senescence. Villacampa, A, Shamoon, L, Valencia, I, Morales, C, Figueiras, S , la Cuesta, F, Sánchez-Niño, D, Díaz-Araya, G, Sánchez-Pérez, I , Lorenzo, Ó, Sánchez-Ferrer, CF, Peiró, C. Aging Dis (PMID: 39012668) (doi:10.14336/AD.2024.0405)
22 Mar | 2024 Platinum iodido drugs show potential anti-tumor activity, affecting cancer cell metabolism and inducing ROS and senescence in gastrointestinal cancer cells. Melones-Herrero, J , Alcalá, S , Ruiz-Cañas, L , Benítez-Buelga, C , Batres-Ramos, S , Calés, C , Lorenzo, O, Perona, R , Quiroga, AG, Sainz, B , Sánchez-Pérez, I . Commun Biol - 7 (1) : 353 (PMID: 38519773) (doi:10.1038/s42003-024-06052-5)
1 Sep | 2023 Dithiobiureas Palladium(II) complexes' studies: From their synthesis to their biological action. Herrero, JM , Fabra, D, Matesanz, AI, Hernández, C, Sánchez-Pérez, I , Quiroga, AG. J Inorg Biochem - 246 : 112261 (PMID: 37271620) (doi:10.1016/j.jinorgbio.2023.112261)
1 Jul | 2023 Regulatory effects of miR-19a on MAD2 expression and tumorigenesis in gastric cancer. Bargiela-Iparraguirre, J , Herrero, JM , Pajuelo-Lozano, N, Perez, M, Perona, R , Quiroga, AG, Calés, C , Sanchez-Perez, I . Genes Dis - 10 (4) : 1180-1182 (PMID: 37397556) (doi:10.1016/j.gendis.2023.02.025)
16 Oct | 2021 ERK5 signalling pathway is a novel target of sorafenib: Implication in EGF biology. Ortega-Muelas, M, Roche, O , Fernández-Aroca, DM, Encinar, JA, Albandea-Rodríguez, D , Arconada-Luque, E, Pascual-Serra, R, Muñoz, I , Sánchez-Pérez, I , Belandia, B , Ruiz-Hidalgo, MJ, Sánchez-Prieto, R . J Cell Mol Med (PMID: 34655447) (doi:10.1111/jcmm.16990)
1 Apr | 2021 Therapeutic efficiency of the APAF-1 antagonist LPT99 in a rat model of cisplatin-induced hearing loss. Murillo-Cuesta, S , Celaya, AM , Cervantes, B , Bermúdez-Muñoz, JM , Rodríguez-de la Rosa, L , Contreras, J , Sánchez-Pérez, I , Varela-Nieto, I . Clin Transl Med - 11 (4) : e363 (PMID: 33931965) (doi:10.1002/ctm2.363)
25 Jul | 2020 Targeting MAD2 modulates stemness and tumorigenesis in human Gastric Cancer cell lines. Pajuelo-Lozano, N , Alcalá, S , Sainz, B , Perona, R , Sanchez-Perez, I . Theranostics - 10 (21) : 9601-9618 (PMID: 32863948) (doi:10.7150/thno.49270)
24 Dec | 2019 New Findings in the Signaling Pathways of cis and trans Platinum Iodido Complexes' Interaction with DNA of Cancer Cells. Quiroga, AG, Cama, M , Pajuelo-Lozano, N , Álvarez-Valdés, A, Perez, IS . ACS Omega - 4 (26) : 21855-21861 (PMID: 31891063) (doi:10.1021/acsomega.9b02831)
1 Jun | 2019 P53 pathway is a major determinant in the radiosensitizing effect of Palbociclib: Implication in cancer therapy. Fernández-Aroca, DM, Roche, O, Sabater, S, Pascual-Serra, R, Ortega-Muelas, M, Sánchez Pérez, I , Belandia, B , Ruiz-Hidalgo, MJ, Sánchez-Prieto, R . Cancer Lett. - 451 : 23-33 (PMID: 30872077) (doi:10.1016/j.canlet.2019.02.049)
2 Apr | 2019 Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss. Celaya, AM , Sánchez-Pérez, I , Bermúdez-Muñoz, JM , Rodríguez-de la Rosa, L , Pintado-Berninches, L , Perona, R , Murillo-Cuesta, S , Varela-Nieto, I . Elife - 8 (PMID: 30938680) (doi:10.7554/eLife.39159)
17 Oct | 2018 XPA, XPC, and XPD Modulate Sensitivity in Gastric Cisplatin Resistance Cancer Cells. Pajuelo-Lozano, N , Bargiela-Iparraguirre, J , Dominguez, G , Quiroga, AG, Perona, R , Sanchez-Perez, I . Front Pharmacol - 9 : 1197 (PMID: 30386247) (doi:10.3389/fphar.2018.01197)
21 Feb | 2018 Using phosphine ligands with a biological role to modulate reactivity in novel platinum complexes. Echeverri, M, Alvarez-Valdés, A, Navas, F, Perles, J, Sánchez-Pérez, I , Quiroga, AG. R Soc Open Sci - 5 (2) : 171340 (PMID: 29515851) (doi:10.1098/rsos.171340)
15 Feb | 2018 The human PKP2/plakophilin-2 gene is induced by Wnt/β-catenin in normal and colon cancer-associated fibroblasts. Niell, N , Larriba, MJ , Ferrer-Mayorga, G , Sánchez-Pérez, I , Cantero, R, Real, FX, Del Peso, L , Muñoz, A , González-Sancho, JM . Int. J. Cancer - 142 (4) : 792-804 (PMID: 29044515) (doi:10.1002/ijc.31104)
26 Jul | 2017 In vivo FRET-FLIM reveals cell-type-specific protein interactions in Arabidopsis roots. Long, Y, Stahl, Y, Weidtkamp-Peters, S, Postma, M, Zhou, W, Goedhart, J, Sánchez-Pérez, MI , Gadella, TWJ, Simon, R, Scheres, B, Blilou, I. Nature (PMID: 28746306) (doi:10.1038/nature23317)
12 Feb | 2016 CHK1 expression in Gastric Cancer is modulated by p53 and RB1/E2F1: implications in chemo/radiotherapy response. Bargiela-Iparraguirre, J , Prado-Marchal, L, Fernandez-Fuente, M, Gutierrez-González, A, Moreno-Rubio, J, Muñoz-Fernandez, M, Sereno, M, Sanchez-Prieto, R , Perona, R , Sanchez-Perez, I . Sci Rep - 6 : 21519 (PMID: 26867682) (doi:10.1038/srep21519)
1 Aug | 2015 Hepatitis C virus-mediated Aurora B kinase inhibition modulates inflammatory pathway and viral infectivity. Madejón, A, Sheldon, J, Francisco-Recuero, I , Perales, C, Domínguez-Beato, M, Lasa, M , Sánchez-Perez, I , Muntané, J, Domingo, E, García-Samaniego, J, Sánchez-Pacheco, A . J. Hepatol. - 63 (2) : 312-319 (PMID: 25733156) (doi:10.1016/j.jhep.2015.02.036)
4 Sep | 2014 E1a promotes c-Myc-dependent replicative stress: implications in glioblastoma radiosensitization. Valero, ML, Cimas, FJ, Arias, L, Melgar-Rojas, P, García, E, Callejas-Valera, JL, García-Cano, J, Serrano-Oviedo, L, de la Cruz-Morcillo, MÁ, Sánchez-Pérez, I , Sánchez-Prieto, R . Cell Cycle - 13 (1) : 52-61 (PMID: 24196438) (doi:10.4161/cc.26754)
1 Apr | 2014 Mad2 and BubR1 modulates tumourigenesis and paclitaxel response in MKN45 gastric cancer cells. Bargiela-Iparraguirre, J , Prado-Marchal, L, Pajuelo-Lozano, N, Jiménez, B , Perona, R , Sánchez-Pérez, I . Cell Cycle - 13 (22) : 3590-3601 (PMID: 25483095) (doi:10.4161/15384101.2014.962952)
1 Mar | 2013 Targeting Chk2 improves gastric cancer chemotherapy by impairing DNA damage repair. Gutiérrez-González, A, Belda-Iniesta, C , Bargiela-Iparraguirre, J , Dominguez, G, García Alfonso, P, Perona, R , Sanchez-Perez, I . Apoptosis - 18 (3) : 347-360 (PMID: 23271172) (doi:10.1007/s10495-012-0794-2)
6 Feb | 2012 Reduced protein stability of human DJ-1/PARK7 L166P, linked to autosomal recessive Parkinson disease, is due to direct endoproteolytic cleavage by the proteasome. Alvarez-Castelao, B , Muñoz, C , Sánchez, I , Goethals, M, Vandekerckhove, J, Castaño, JG . Biochim. Biophys. Acta - 1823 (2) : 524-533 (PMID: 22173095) (doi:10.1016/j.bbamcr.2011.11.010)
10 Feb | 2011 DUSP1/MKP1 promotes angiogenesis, invasion and metastasis in non-small-cell lung cancer. Moncho-Amor, V , Ibañez de Cáceres, I , Bandres, E, Martínez-Poveda, B , Orgaz, JL , Sánchez-Pérez, I , Zazo, S, Rovira, A, Albanell, J, Jiménez, B , Rojo, F, Belda-Iniesta, C , García-Foncillas, J, Perona, R . Oncogene - 30 (6) : 668-678 (PMID: 20890299) (doi:10.1038/onc.2010.449)
4 Feb | 2010 Checkpoint kinase 1 modulates sensitivity to cisplatin after spindle checkpoint activation in SW620 cells. Peralta-Sastre, A , Manguan-Garcia, C , de Luis, A, Belda-Iniesta, C , Moreno, S, Perona, R , Sanchez-Perez, I . Int. J. Biochem. Cell Biol. - 42 (2) : 318-328 (PMID: 19931410) (doi:10.1016/j.biocel.2009.11.011)
28 Dec | 2009 MKP1 repression is required for the chemosensitizing effects of NF-kappaB and PI3K inhibitors to cisplatin in non-small cell lung cancer. Cortes-Sempere, M , Chattopadhyay, S, Rovira, A, Rodriguez-Fanjul, V , Belda-Iniesta, C , Tapia, M, Cejas, P , Machado-Pinilla, R , Manguan-García, C , Sánchez-Pérez, I , Nistal, M, Moratilla, C , de Castro-Carpeño, J, Gonzalez-Barón, M, Albanell, J, Perona, R . Cancer Lett. - 286 (2) : 206-216 (PMID: 19553005) (doi:10.1016/j.canlet.2009.05.029)
7 Aug | 2009 Clinical impact of aneuploidy on gastric cancer patients. Sánchez-Pérez, I , García Alonso, P, Belda Iniesta, C. Clin Transl Oncol - 11 (8) : 493-498 (PMID: 19661021)
18 Jan | 2009 hCCR4/cNOT6 targets DNA-damage response proteins. Sanchez-Perez, I , Manguan-Garcia, C , Menacho-Marquez, M, Murguía, JR , Perona, R . Cancer Lett. - 273 (2) : 281-291 (PMID: 18818012) (doi:10.1016/j.canlet.2008.08.026)
17 Sep | 2008 Role of CHK2 in cancer development. Perona, R , Moncho-Amor, V , Machado-Pinilla, R , Belda-Iniesta, C , Sánchez Pérez, I . Clin Transl Oncol - 10 (9) : 538-542 (PMID: 18796370)
6 Mar | 2008 The role of the NFkappaB signalling pathway in cancer. Cortés Sempere, M, Rodríguez Fanjul, V , Sánchez Pérez, I , Perona, R . Clin Transl Oncol - 10 (3) : 143-147 (PMID: 18321816)
1 Mar | 2008 A dyskerin motif reactivates telomerase activity in X-linked dyskeratosis congenita and in telomerase-deficient human cells. Machado-Pinilla, R , Sánchez-Pérez, I , Murguía, JR , Sastre, L , Perona, R . Blood - 111 (5) : 2606-2614 (PMID: 18057229) (doi:10.1182/blood-2007-04-083261)
1 Oct | 2007 Human recombinant erythropoietin does not promote cancer growth in presence of functional receptors expressed in cancer cells. Belda-Iniesta, C , Perona, R , Carpeño, Jde C, Cejas, P , Casado, E , Manguan-García, C , Ibanez de Caceres, I , Sanchez-Perez, I , Andreu, FB, Ferreira, JA, Aguilera, A, de la Peña, J, Perez-Sánchez, E, Madero, R, Feliu, J, Sereno, M, González-Barón, M. Cancer Biol. Ther. - 6 (10) : 1600-1605 (PMID: 17938574)
1 Oct | 2007 Signalling pathways involved in clinical responses to chemotherapy. Perona, R , Sánchez-Pérez, I . Clin Transl Oncol - 9 (10) : 625-633 (PMID: 17974523)
28 Sep | 2006 DNA repair inhibitors in cancer treatment. Sánchez-Pérez, I . Clin Transl Oncol - 8 (9) : 642-646 (PMID: 17005466)
17 Aug | 2005 The DASH complex and Klp5/Klp6 kinesin coordinate bipolar chromosome attachment in fission yeast. Sanchez-Perez, I , Renwick, SJ, Crawley, K, Karig, I, Buck, V, Meadows, JC, Franco-Sanchez, A, Fleig, U, Toda, T, Millar, JB. EMBO J. - 24 (16) : 2931-2943 (PMID: 16079915) (doi:10.1038/sj.emboj.7600761)
30 Jul | 2004 Subcellular localization determines the protective effects of activated ERK2 against distinct apoptogenic stimuli in myeloid leukemia cells. Ajenjo, N, Cañón, E , Sánchez-Pérez, I , Matallanas, D, León, J, Perona, R , Crespo, P . J. Biol. Chem. - 279 (31) : 32813-32823 (PMID: 15173174) (doi:10.1074/jbc.M313656200)
30 Mar | 2004 FK506 sensitizes mammalian cells to high osmolarity by modulating p38 MAP kinase activation. Sanchez-Perez, I , Rodriguez-Hernandez, CJ, Manguan-García, C , Torres, A, Perona, R , Murguía, JR . Cell. Mol. Life Sci. - 61 (6) : 700-708 (PMID: 15052412) (doi:10.1007/s00018-003-3388-x)
9 Feb | 2004 Control of oncogenesis and cancer therapy resistance. Perona, R , Sánchez-Pérez, I . Br. J. Cancer - 90 (3) : 573-577 (PMID: 14760366) (doi:10.1038/sj.bjc.6601552)
31 Oct | 2003 The antidiabetic agent sodium tungstate activates glycogen synthesis through an insulin receptor-independent pathway. Domínguez, JE, Muñoz, MC, Zafra, D, Sanchez-Perez, I , Baqué, S, Caron, M, Mercurio, C, Barberà, A, Perona, R , Gomis, R, Guinovart, JJ. J. Biol. Chem. - 278 (44) : 42785-42794 (PMID: 12925525) (doi:10.1074/jbc.M308334200)
5 Sep | 2003 The immunosuppressant FK506 uncovers a positive regulatory cross-talk between the Hog1p and Gcn2p pathways. Rodriguez-Hernandez, CJ, Sanchez-Perez, I , Gil-Mascarell, R, Rodríguez-Afonso, A, Torres, A, Perona, R , Murguia, JR . J. Biol. Chem. - 278 (36) : 33887-33895 (PMID: 12813040) (doi:10.1074/jbc.M305220200)
5 Mar | 2003 Schizosaccharomyces pombe essential genes: a pilot study. Decottignies, A, Sanchez-Perez, I , Nurse, P. Genome Res. - 13 (3) : 399-406 (PMID: 12618370) (doi:10.1101/gr.636103)
8 Oct | 2002 Growth hormone protects against radiotherapy-induced cell death. Madrid, O, Varea, S, Sanchez-Perez, I , Gomez-Garcia, L, De Miguel, E, Gomez De Segura, IA, Perona, R . Eur. J. Endocrinol. - 147 (4) : 535-541 (PMID: 12370117)
15 Aug | 2002 Cell stress and MEKK1-mediated c-Jun activation modulate NFkappaB activity and cell viability. Sánchez-Pérez, I , Benitah, SA, Martínez-Gomariz, M, Lacal, JC , Perona, R . Mol. Biol. Cell - 13 (8) : 2933-2945 (PMID: 12181357) (doi:10.1091/mbc.E02-01-0022)
26 Oct | 2000 CL100/MKP-1 modulates JNK activation and apoptosis in response to cisplatin. Sánchez-Pérez, I , Martínez-Gomariz, M, Williams, D, Keyse, SM, Perona, R . Oncogene - 19 (45) : 5142-5152 (PMID: 11064451) (doi:10.1038/sj.onc.1203887)
18 Jun | 1999 Lack of c-Jun activity increases survival to cisplatin. Sánchez-Pérez, I , Perona, R . FEBS Lett. - 453 (1-2) : 151-158 (PMID: 10403393)
29 Jan | 1998 Cisplatin induces a persistent activation of JNK that is related to cell death. Sánchez-Perez, I , Murguía, JR , Perona, R . Oncogene - 16 (4) : 533-540 (PMID: 9484843) (doi:10.1038/sj.onc.1201578)
15 Feb | 1997 Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins. Perona, R , Montaner, S , Saniger, L, Sánchez-Pérez, I , Bravo, R, Lacal, JC . Genes Dev. - 11 (4) : 463-475 (PMID: 9042860)