28 mar | 2024 Reprogramming of the LXRα Transcriptome Sustains Macrophage Secondary Inflammatory Responses. Vladimir de la Rosa, J, Tabraue, C, Huang, Z, Orizaola, MC , Martin-Rodríguez, P, Steffensen, KR, Zapata, JM , Boscá, L , Tontonoz, P, Alemany, S , Treuter, E, Castrillo, A . Adv Sci (Weinh) (PMID: 38549193) (doi:10.1002/advs.202307201)
1 dic | 2023 The thyroid hormone enhances mouse embryonic fibroblasts reprogramming to pluripotent stem cells: role of the nuclear receptor corepressor 1. Contreras-Jurado, C , Montero-Pedrazuela, A , Pérez, RF, Alemany, S , Fraga, MF, Aranda, A . Front Endocrinol (Lausanne) - 14 : 1235614 (PMID: 38107517) (doi:10.3389/fendo.2023.1235614)
8 feb | 2023 Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease. Gutierrez, AH, Mazariegos, MS, Alemany, S , Nevzorova, YA, Cubero, FJ, Sanz-García, C. Biochim Biophys Acta Mol Basis Dis - 1869 (4) : 166660 (PMID: 36764206) (doi:10.1016/j.bbadis.2023.166660)
9 nov | 2022 Free triiodothyronine levels and age influences the metabolic profile and COVID-19 severity parameters in euthyroid and levothyroxine-treated patients. Amich, I, Anguita, E, Escribano-Serrat, S, Alvarez, C, Rodríguez-Muñoz, D , García, V, Bello, R, Peña-Pedrosa, JA, Martínez-Micaelo, N, Amigó, N, Ortiz, P, Torrejón, MJ, Boscá, L , Martín-Sánchez, J, Aranda, A , Alemany, S . Front Endocrinol (Lausanne) - 13 : 1025032 (PMID: 36440226) (doi:10.3389/fendo.2022.1025032)
22 jul | 2022 Regulation of metabolic and transcriptional responses by the thyroid hormone in cellular models of murine macrophages. López-Mateo, I , Rodríguez-Muñoz, D , de La Rosa, JV, Castrillo, A , Alemany, S , Aranda, A . Front Immunol - 13 : 923727 (PMID: 35935955) (doi:10.3389/fimmu.2022.923727)
8 abr | 2022 Hypothyroidism confers tolerance to cerebral malaria. Rodriguez-Muñoz, D , Sánchez, Á , Pérez-Benavente, S, Contreras-Jurado, C , Montero-Pedrazuela, A , Toledo-Castillo, M , Gutiérrez-Hernández, M , Rodrigues-Díez, R, Folgueira, C, Briones, AM, Sabio, G, Monedero-Cobeta, I, Chávez-Coira, I, Castejón, D, Fernández-Valle, E, Regadera, J, Bautista, JM, Aranda, A , Alemany, S . Sci Adv - 8 (14) : eabj7110 (PMID: 35385300) (doi:10.1126/sciadv.abj7110)
28 oct | 2020 Stress erythropoiesis in atherogenic mice. Sánchez, Á , Orizaola, MC , Rodríguez-Muñoz, D , Aranda, A , Castrillo, A , Alemany, S . Sci Rep - 10 (1) : 18469 (PMID: 33116141) (doi:10.1038/s41598-020-74665-x)
1 feb | 2020 Abnormal Dendritic Cell-poiesis in Patients With Lower-risk Myelodysplastic Syndromes. Sánchez, Á , Anguita, E, Chaparro, A, Roldán-Etcheverry, JJ, López-García, A, Ramos-Acosta, C, Oancea, R, Rodriguez-Muñoz, D , Alemany, S . Hemasphere - 4 (1) : e335 (PMID: 32072149) (doi:10.1097/HS9.0000000000000335)
1 ene | 2020 Hematopoiesis in aged female mice devoid of thyroid hormone receptors. Sánchez, Á , Contreras-Jurado, C , Rodríguez, D , Regadera, J, Alemany, S , Aranda, A . J. Endocrinol. - 244 (1) : 83-94 (PMID: 31585438) (doi:10.1530/JOE-19-0339)
23 nov | 2019 The thyroid hormone receptor β inhibits self-renewal capacity of breast cancer stem cells. López-Mateo, I , Alonso-Merino, E , Suárez-Cabrera, C, Park, JW, Cheng, SY, Alemany, S , Paramio, JM, Aranda, A . Thyroid (PMID: 31760908) (doi:10.1089/thy.2019.0175)
2 ene | 2019 Common and Differential Transcriptional Actions of Nuclear Receptors LXRα and LXRβ in macrophages. Ramón-Vázquez, A , de la Rosa, JV, Tabraue, C, Lopez, F, Díaz-Chico, BN, Bosca, L , Tontonoz, P, Alemany, S , Castrillo, A . Mol. Cell. Biol. (PMID: 30602495) (doi:10.1128/MCB.00376-18)
2 nov | 2018 Influence of Preparation Methods of Chitooligosaccharides on Their Physicochemical Properties and Their Anti-Inflammatory Effects in Mice and in RAW264.7 Macrophages. Sánchez, Á , Mengíbar, M, Fernández, M , Alemany, S , Heras, A, Acosta, N. Mar Drugs - 16 (11) (PMID: 30400250) (doi:10.3390/md16110430)
1 mayo | 2018 Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity. Alsina-Beauchamp, D, Escós, A, Fajardo, P, González-Romero, D, Díaz-Mora, E, Risco, A, Martín-Serrano, MA, Del Fresno, C, Dominguez-Andrés, J, Aparicio, N, Zur, R, Shpiro, N, Brown, GD, Ardavín, C, Netea, MG, Alemany, S , Sanz-Ezquerro, JJ, Cuenda, A. EMBO Mol Med - 10 (5) (PMID: 29661910) (doi:10.15252/emmm.201708485)
31 oct | 2017 SIRT1 CONTROLS ACETAMINOPHEN HEPATOTOXICITY BY MODULATING INFLAMMATION AND OXIDATIVE STRESS. Rada, P , Pardo, V , Mobasher, M, Garcia, I, Ruiz, L , Gonzalez Rodriguez, A, Sánchez Ramos, C, Muntané, J, Alemany, S , James, LP, Simpson, KJ, Monsalve, M , Valdecantos, MP , Valverde, A . Antioxid. Redox Signal. (PMID: 29084443) (doi:10.1089/ars.2017.7373)
10 jul | 2017 Map3k8 controls granulocyte colony-stimulating factor production and neutrophil precursor proliferation in lipopolysaccharide-induced emergency granulopoiesis. Sánchez, Á , Relaño, C , Carrasco, A , Contreras-Jurado, C , Martín-Duce, A, Aranda, A , Alemany, S . Sci Rep - 7 (1) : 5010 (PMID: 28694430) (doi:10.1038/s41598-017-04538-3)
1 feb | 2017 Map3k8 Modulates Monocyte State and Atherogenesis in ApoE-/- Mice. Sanz-Garcia, C, Sánchez, Á , Contreras-Jurado, C , Cales, C, Barranquero, C, Muñoz, M, Merino, R, Escudero, P, Sanz, MJ, Osada, J, Aranda, A , Alemany, S . Arterioscler. Thromb. Vasc. Biol. - 37 (2) : 237-246 (PMID: 27856455) (doi:10.1161/ATVBAHA.116.308528)
3 ago | 2016 The Thyroid Hormone Receptors Inhibit Hepatic Interleukin-6 Signaling During Endotoxemia. Contreras-Jurado, C , Alonso-Merino, E , Saiz-Ladera, C, Valiño, AJ, Regadera, J, Alemany, S , Aranda, A . Sci Rep - 6 : 30990 (PMID: 27484112) (doi:10.1038/srep30990)
3 ago | 2015 Metabolic signatures linked to macrophage polarization: from glucose metabolism to oxidative phosphorylation. Boscá, L , González-Ramos, S , Prieto, P , Fernández-Velasco, M , Mojena, M , Martín-Sanz, P , Alemany, S . Biochem. Soc. Trans. - 43 (4) : 740-744 (PMID: 26551722) (doi:10.1042/BST20150107)
1 jul | 2015 The Tpl2 Kinase Regulates the COX-2/Prostaglandin E2 Axis in Adipocytes in Inflammatory Conditions. Berthou, F, Ceppo, F, Dumas, K, Massa, F, Vergoni, B, Alemany, S , Cormont, M, Tanti, JF. Mol. Endocrinol. - 29 (7) : 1025-1036 (PMID: 26020725) (doi:10.1210/me.2015-1027)
3 jun | 2014 Cot/tpl2 participates in the activation of macrophages by adiponectin. Sanz-Garcia, C, Nagy, LE, Lasunción, MA, Fernandez, M, Alemany, S . J. Leukoc. Biol. - 95 (6) : 917-930 (PMID: 24532642) (doi:10.1189/jlb.0913486)
24 mayo | 2013 Sterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2. Sanz-Garcia, C, Ferrer-Mayorga, G , González-Rodríguez, Á , Valverde, AM , Martín-Duce, A, Velasco-Martín, JP, Regadera, J, Fernández, M , Alemany, S . J. Biol. Chem. - 288 (21) : 15342-15351 (PMID: 23572518) (doi:10.1074/jbc.M112.439547)
1 ago | 2012 Cot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like receptor-activated macrophages. López-Pelaéz, M , Fumagalli, S, Sanz, C , Herrero, C, Guerra, S, Fernandez, M, Alemany, S . Mol. Biol. Cell - 23 (15) : 2982-2992 (PMID: 22675026) (doi:10.1091/mbc.E12-02-0135)
12 ago | 2011 Involvement of Cot activity in the proliferation of ALCL lymphoma cells. Fernández, M , Manso, R , Bernaldo de Quirós, F, Bernáldez, F, López, P , Martín-Duce, A, Alemany, S . Biochem. Biophys. Res. Commun. - 411 (4) : 655-660 (PMID: 21741362) (doi:10.1016/j.bbrc.2011.06.157)
1 jun | 2011 Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression. López-Peláez, M , Soria-Castro, I , Boscá, L , Fernández, M , Alemany, S . Eur. J. Immunol. - 41 (6) : 1733-1741 (PMID: 21469113) (doi:10.1002/eji.201041101)
29 oct | 2010 Cot/tpl2 (MAP3K8) mediates myeloperoxidase activity and hypernociception following peripheral inflammation. Soria-Castro, I , Krzyzanowska, A, Pelaéz, ML , Regadera, J, Ferrer, G, Montoliu, L, Rodríguez-Ramos, R, Fernández, M , Alemany, S . J. Biol. Chem. - 285 (44) : 33805-33815 (PMID: 20736176) (doi:10.1074/jbc.M110.169409)
1 sep | 2008 COX2 expression and Erk1/Erk2 activity mediate Cot-induced cell migration. Rodríguez, C, López, P , Pozo, M , Duce, AM, López-Pelaéz, M , Fernández, M , Alemany, S . Cell. Signal. - 20 (9) : 1625-1631 (PMID: 18572386) (doi:10.1016/j.cellsig.2008.05.008)
1 sep | 2006 TRAF6 and Src kinase activity regulates Cot activation by IL-1. Rodríguez, C, Pozo, M , Nieto, E , Fernández, M , Alemany, S . Cell. Signal. - 18 (9) : 1376-1385 (PMID: 16371247) (doi:10.1016/j.cellsig.2005.10.016)
5 jun | 2006 Bruton's tyrosine kinase is not essential for LPS-induced activation of human monocytes. Pérez de Diego, R, López-Granados, E, Pozo, M , Rodríguez, C, Sabina, P, Ferreira, A, Fontan, G, García-Rodríguez, MC , Alemany, S . J. Allergy Clin. Immunol. - 117 (6) : 1462-1469 (PMID: 16751014) (doi:10.1016/j.jaci.2006.01.037)
26 dic | 2003 15-Deoxy-Delta12,14-prostaglandin J2 regulates endogenous Cot MAPK kinase kinase 1 activity induced by lipopolysaccharide. Caivano, M, Rodriguez, C, Cohen, P, Alemany, S . J. Biol. Chem. - 278 (52) : 52124-52130 (PMID: 14557273) (doi:10.1074/jbc.M306583200)
1 oct | 2003 The COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activity. Gándara, ML , López, P , Hernando, R, Castaño, JG , Alemany, S . Mol. Cell. Biol. - 23 (20) : 7377-7390 (PMID: 14517305)
20 jul | 2001 Cot kinase induces cyclooxygenase-2 expression in T cells through activation of the nuclear factor of activated T cells. de Gregorio, R, Iñiguez, MA, Fresno, M, Alemany, S . J. Biol. Chem. - 276 (29) : 27003-27009 (PMID: 11356833) (doi:10.1074/jbc.M100885200)
15 mayo | 2001 p27kip protein levels and E2F activity are targets of Cot kinase during G1 phase progression in T cells. Velasco-Sampayo, A, Alemany, S . J. Immunol. - 166 (10) : 6084-6090 (PMID: 11342626)
6 oct | 2000 COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activation. Sánchez-Góngora, E , Lisbona, C , de Gregorio, R, Ballester, A , Calvo, V , Pérez-Jurado, L, Alemany, S . J. Biol. Chem. - 275 (40) : 31379-31386 (PMID: 10896655) (doi:10.1074/jbc.M000382200)
13 ago | 1999 Regulation of cyclooxygenase activity by metamizol. Campos, C, de Gregorio, R, García-Nieto, R, Gago, F, Ortiz, P, Alemany, S . Eur. J. Pharmacol. - 378 (3) : 339-347 (PMID: 10493111)
5 jun | 1998 Cot kinase activates tumor necrosis factor-alpha gene expression in a cyclosporin A-resistant manner. Ballester, A , Velasco, A, Tobeña, R , Alemany, S . J. Biol. Chem. - 273 (23) : 14099-14106 (PMID: 9603908)
1 nov | 1997 Regulation of ERK2 dephosphorylation in G1-stimulated rat T lymphoblasts. Lisbona, C , Alemany, S , Fernández-Renart, M . J. Clin. Immunol. - 17 (6) : 494-501 (PMID: 9418190)
15 ago | 1997 Cot kinase regulation of IL-2 production in Jurkat T cells. Ballester, A , Tobeña, R , Lisbona, C , Calvo, V , Alemany, S . J. Immunol. - 159 (4) : 1613-1618 (PMID: 9257820)
1 nov | 1996 Interleukin-2 induces gamma-S-adenosyl-L-methionine synthetase gene expression during T-lymphocyte activation. Tobeña, R , Horikawa, S, Calvo, V , Alemany, S . Biochem. J. - 319 ( Pt 3) : 929-933 (PMID: 8921001)
1 nov | 1996 The catalytic domain of pp56(lck), but not its regulatory domain, is sufficient for inducing IL-2 production. Carrera, AC, Calvo, V , Borlado, LR, Paradis, H, Alemany, S , Roberts, TM, Martinez-A, C. J. Immunol. - 157 (9) : 3775-3782 (PMID: 8892605)
1 nov | 1994 Raf-1 and ERK2 kinases are required for phorbol 12,13-dibutyrate-stimulated proliferation of rat lymphoblasts. ERK2 activation precedes Raf-1 hyperphosphorylation. Lisbona, C , Alemany, S , Calvo, V , Fernandez-Renart, M. Eur. J. Immunol. - 24 (11) : 2746-2754 (PMID: 7957567) (doi:10.1002/eji.1830241126)
15 oct | 1994 Induction of NGFI-B gene expression during T cell activation. Role of protein phosphatases. Garcia, I, Pipaon, C, Alemany, S , Perez-Castillo, A . J. Immunol. - 153 (8) : 3417-3425 (PMID: 7930567)
15 sep | 1993 NGFI-A gene expression is necessary for T lymphocyte proliferation. Perez-Castillo, A , Pipaón, C, García, I, Alemany, S . J. Biol. Chem. - 268 (26) : 19445-19450 (PMID: 8366092)
1 dic | 1992 Beta-endorphin inhibits interleukin-2 release and expression of interleukin-2 receptors in concanavalin A-stimulated splenic lymphocytes. Garcia, I, Perez-Castillo, A , Moreno, J, Alemany, S . Lymphokine Cytokine Res. - 11 (6) : 339-345 (PMID: 1477186)
26 oct | 1990 Phospho-oligosaccharide dependent phosphorylation of ATP citrate lyase. Puerta, J, Mato, JM , Alemany, S . Adv. Enzyme Regul. - 30 : 109-117 (PMID: 2119547)
30 jul | 1990 Phosphorylation control by insulin in adipocytes is interfered with at a post-receptor step by phosphoinositol and glucosamine. Strålfors, P, Alemany, S . FEBS Lett. - 268 (1) : 169-172 (PMID: 1696549)
25 mar | 1990 Modulation of casein kinase II activity by the polar head group of an insulin-sensitive glycosyl-phosphatidylinositol. Alemany, S , Puerta, J, Guadaño, A, Mato, JM . J. Biol. Chem. - 265 (9) : 4849-4852 (PMID: 2138621)
28 dic | 1988 Specific loss of the high-molecular-weight form of S-adenosyl-L-methionine synthetase in human liver cirrhosis. Cabrero, C, Duce, AM, Ortiz, P, Alemany, S , Mato, JM . Hepatology - 8 (6) : 1530-1534 (PMID: 3192166)
29 sep | 1988 Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle. Cohen, P, Alemany, S , Hemmings, BA, Resink, TJ, Strålfors, P, Tung, HY. Meth. Enzymol. - 159 : 390-408 (PMID: 2842604)
10 feb | 1988 Conversion of rat liver S-adenosyl-L-methionine synthetase from high-Mr form to low-Mr form by LiBr. Cabrero, C, Alemany, S . Biochim. Biophys. Acta - 952 (3) : 277-281 (PMID: 2827780)
30 dic | 1987 Purification and comparison of two forms of S-adenosyl-L-methionine synthetase from rat liver. Cabrero, C, Puerta, J, Alemany, S . Eur. J. Biochem. - 170 (1-2) : 299-304 (PMID: 3121322)
16 dic | 1987 Phospho-dephospho-control by insulin is mimicked by a phospho-oligosaccharide in adipocytes. Alemany, S , Mato, JM , Strålfors, P. Nature - 330 (6143) : 77-79 (PMID: 3313056) (doi:10.1038/330077a0)
14 sep | 1987 Isolation and sequence analysis of a cDNA clone encoding the entire catalytic subunit of a type-2A protein phosphatase. da Cruz e Silva, OB, Alemany, S , Campbell, DG, Cohen, PT. FEBS Lett. - 221 (2) : 415-422 (PMID: 3040474)
1 abr | 1986 The protein phosphatases involved in cellular regulation. Evidence that dephosphorylation of glycogen phosphorylase and glycogen synthase in the glycogen and microsomal fractions of rat liver are catalysed by the same enzyme: protein phosphatase-1. Alemany, S , Pelech, S, Brierley, CH, Cohen, P. Eur. J. Biochem. - 156 (1) : 101-110 (PMID: 3007140)
31 mar | 1986 Phosphorylase a is an allosteric inhibitor of the glycogen and microsomal forms of rat hepatic protein phosphatase-1. Alemany, S , Cohen, P. FEBS Lett. - 198 (2) : 194-202 (PMID: 3007211)
15 abr | 1985 The protein phosphatases involved in cellular regulation. 2. Purification, subunit structure and properties of protein phosphatases-2A0, 2A1, and 2A2 from rabbit skeletal muscle. Tung, HY, Alemany, S , Cohen, P. Eur. J. Biochem. - 148 (2) : 253-263 (PMID: 2985385)
15 nov | 1984 The protein phosphatases involved in cellular regulation. Antibody to protein phosphatase-2A as a probe of phosphatase structure and function. Alemany, S , Tung, HY, Shenolikar, S, Pilkis, SJ, Cohen, P. Eur. J. Biochem. - 145 (1) : 51-56 (PMID: 6092082)
1 oct | 1984 Purification and photoaffinity labelling of lipid methyltransferase from rat liver. Pajares, MA , Alemany, S , Varela, I , Marin Cao, D, Mato, JM . Biochem. J. - 223 (1) : 61-66 (PMID: 6497846)
15 oct | 1983 [Hormonal regulation of the synthesis of phosphatidylcholine by transmethylation]. Mato, JM , Alvarez Chiva, V, Marín Cao, D, Varela, I , García Gil, M, Alemany, S . Rev Clin Esp - 171 (1) : 7-10 (PMID: 6658087)
3 oct | 1983 Effect of fatty acid anilides on the generation of arachidonic acid by human polymorphonuclear leukocytes. Gil, MG, van Lookeren Campagne, MW, Alemany, S , Municio, AM, Mato, JM . FEBS Lett. - 162 (1) : 151-155 (PMID: 6413256)
1 jul | 1983 What is the function of phospholipid N-methylation? Mato, JM , Alemany, S . Biochem. J. - 213 (1) : 1-10 (PMID: 6311156)
15 nov | 1982 Inhibition of phosphatidylcholine synthesis by vasopressin and angiotensin in rat hepatocytes. Alemany, S , Varela, I , Mato, JM . Biochem. J. - 208 (2) : 453-457 (PMID: 6818955)
25 ago | 1982 Calmodulin regulation of phospholipid and fatty acid methylation by rat liver microsomes. Alemany, S , Varela, I , Harper, JF, Mato, JM . J. Biol. Chem. - 257 (16) : 9249-9251 (PMID: 6809733)
30 nov | 1981 Stimulation by vasopressin and angiotensin of phospholipid methyltransferase in isolated rat hepatocytes. Alemany, S , Varela, I , Mato, JM . FEBS Lett. - 135 (1) : 111-114 (PMID: 6797839)
1 dic | 1980 Regulation by guanosine 3':5'-cyclic monophosphate of phospholipid methylation during chemotaxis in Dictyostelium discoideum. Alemany, S , García Gil, M, Mato, JM . Proc. Natl. Acad. Sci. U.S.A. - 77 (12) : 6996-6999 (PMID: 6261233)
10 oct | 1980 Activation of phospholipid methyltransferase by glucagon in rat hepatocytes. Castaño, JG , Alemany, S , Nieto, A, Mato, JM . J. Biol. Chem. - 255 (19) : 9041-9043 (PMID: 6251072)
30 jun | 1980 Calmodulin modulates phospholipid methylation in Dictyostelium discoideum. Gil, MG, Alemany, S , Cao, DM, Castano, JG, Mato, JM . Biochem. Biophys. Res. Commun. - 94 (4) : 1325-1330 (PMID: 6772186)