7 Oct | 2024 SIRT1 Mediates the Antagonism of Wnt/β-Catenin Pathway by Vitamin D in Colon Carcinoma Cells. García-Martínez, JM , Chocarro-Calvo, A , Martínez-Useros, J, Regueira-Acebedo, N, Fernández-Aceñero, MJ, Muñoz, A , Larriba, MJ , García-Jiménez, C. Int J Biol Sci - 20 (14) : 5495-5509 (PMID: 39494323) (doi:10.7150/ijbs.95875)
29 Apr | 2024 Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids. Bustamante-Madrid, P , Barbáchano, A , Albandea-Rodríguez, D , Rodríguez-Cobos, J , Rodríguez-Salas, N, Prieto, I, Burgos, A, Martínez de Villarreal, J, Real, FX, González-Sancho, JM , Larriba, MJ , Lafarga, M, Muñoz, A , Fernández-Barral, A . Cell Death Dis - 15 (4) : 301 (PMID: 38684650) (doi:10.1038/s41419-024-06680-z)
24 Aug | 2023 Clinico-Pathological Features, Outcomes and Impacts of COVID-19 Pandemic on Patients with Early-Onset Colorectal Cancer: A Single-Institution Experience. Martinez-Perez, D, Viñal, D, Peña-Lopez, J, Jimenez-Bou, D, Ruiz-Gutierrez, I, Martinez-Recio, S, Alameda-Guijarro, M, Rueda-Lara, A, Martin-Montalvo, G, Ghanem, I, Custodio, AB, Trilla-Fuertes, L, Gamez-Pozo, A, Barbachano, A , Rodriguez-Cobos, J , Bustamante-Madrid, P , Fernandez-Barral, A , Burgos, A, Prieto-Nieto, MI, Pastrian, LG, González-Sancho, JM , Muñoz, A , Feliu, J, Rodríguez-Salas, N. Cancers (Basel) - 15 (17) (PMID: 37686518) (doi:10.3390/cancers15174242)
9 Aug | 2023 An amino acid transporter subunit as an antibody-drug conjugate target in colorectal cancer. Montero, JC, Del Carmen, S, Abad, M, Sayagués, JM, Barbáchano, A , Fernández-Barral, A , Muñoz, A , Pandiella, A. J Exp Clin Cancer Res - 42 (1) : 200 (PMID: 37559159) (doi:10.1186/s13046-023-02784-0)
2 Aug | 2023 Vitamin D induces SIRT1 activation through K610 deacetylation in colon cancer. García-Martínez, JM , Chocarro-Calvo, A , Martínez-Useros, J, Fernández-Aceñero, MJ, Fiuza, MC, Cáceres-Rentero, J, De la Vieja, A , Barbáchano, A , Muñoz, A , Larriba, MJ , García Jiménez, C. Elife - 12 (PMID: 37530744) (doi:10.7554/eLife.86913)
18 Jul | 2023 ERK2 stimulates MYC transcription by anchoring CDK9 to the MYC promoter in a kinase activity-independent manner. Agudo-Ibáñez, L , Morante, M, García-Gutiérrez, L, Quintanilla, A, Rodríguez, J, Muñoz, A , León, J, Crespo, P . Sci Signal - 16 (794) : eadg4193 (PMID: 37463244) (doi:10.1126/scisignal.adg4193)
12 Apr | 2023 PKD phosphorylation and COP9/Signalosome modulate intracellular Spry2 protein stability. Martínez, N, Gragera, T, de Lucas, MP, Cámara, AB, Ballester, A, Anta, B, Fernández-Medarde, A, López-Briones, T, Ortega, J, Peña-Jiménez, D, Barbáchano, A , Montero-Calle, A, Cordero, V, Barderas, R, Iglesias, T , Yunta, M, Oliva, JL, Muñoz, A , Santos, E, Zarich, N, Rojas-Cabañeros, JM. Oncogenesis - 12 (1) : 20 (PMID: 37045830) (doi:10.1038/s41389-023-00465-3)
28 Feb | 2023 Tailored chemotherapy for colorectal cancer peritoneal metastases based on a drug-screening platform in patient-derived organoids: a case report. Prieto, I, Barbáchano, A , Rodríguez-Salas, N, Viñal, D, Cortés-Guiral, D, Muñoz, A , Fernández-Barral, A . J Gastrointest Oncol - 14 (1) : 442-449 (PMID: 36915469) (doi:10.21037/jgo-22-599)
7 Jul | 2022 p38γ and p38δ as biomarkers in the interplay of colon cancer and inflammatory bowel diseases. Fajardo, P, Taskova, M, Martín-Serrano, MA, Hansen, J, Slott, S, Jakobsen, AK, Wibom, ML, Salegi, B, Muñoz, A , Barbachano, A , Sharma, A, Gubatan, JM, Habtezion, A, Sanz-Ezquerro, JJ, Astakhova, K, Cuenda, A. Cancer Commun (Lond) (PMID: 35796643) (doi:10.1002/cac2.12331)
23 May | 2022 p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis. Solé, L, Lobo-Jarne, T, Álvarez-Villanueva, D, Alonso-Marañón, J, Guillén, Y, Guix, M, Sangrador, I, Rozalén, C, Vert, A, Barbachano, A , Lop, J, Salido, M, Bellosillo, B, García-Romero, R, Garrido, M, González, J, Martínez-Iniesta, M, López-Arribillaga, E, Salazar, R, Montagut, C, Torres, F, Iglesias, M, Celià-Terrassa, T, Muñoz, A , Villanueva, A, Bigas, A, Espinosa, L. Nat Commun - 13 (1) : 2866 (PMID: 35606354) (doi:10.1038/s41467-022-30382-9)
30 Mar | 2022 Vitamin D and Cancer: An Historical Overview of the Epidemiology and Mechanisms. Muñoz, A , Grant, WB. Nutrients - 14 (7) (PMID: 35406059) (doi:10.3390/nu14071448)
30 Jan | 2022 An update on vitamin D signaling and cancer. Carlberg, C, Muñoz, A . Semin Cancer Biol (PMID: 32485310) (doi:10.1016/j.semcancer.2020.05.018)
28 May | 2021 Organoids and Colorectal Cancer. Barbáchano, A , Fernández-Barral, A , Bustamante-Madrid, P , Prieto, I, Rodríguez-Salas, N, Larriba, MJ , Muñoz, A . Cancers (Basel) - 13 (11) (PMID: 34071313) (doi:10.3390/cancers13112657)
28 Apr | 2021 Tankyrases as modulators of pro-tumoral functions: molecular insights and therapeutic opportunities. Zamudio-Martinez, E, Herrera-Campos, AB, Muñoz, A , Rodríguez-Vargas, JM, Oliver, FJ. J Exp Clin Cancer Res - 40 (1) : 144 (PMID: 33910596) (doi:10.1186/s13046-021-01950-6)
19 Nov | 2020 Wnt and Vitamin D at the Crossroads in Solid Cancer. González-Sancho, JM , Larriba, MJ , Muñoz, A . Cancers (Basel) - 12 (11) (PMID: 33227961) (doi:10.3390/cancers12113434)
25 Aug | 2020 Vitamin D Effects on Cell Differentiation and Stemness in Cancer. Fernández-Barral, A , Bustamante-Madrid, P , Ferrer-Mayorga, G , Barbáchano, A , Larriba, MJ , Muñoz, A . Cancers (Basel) - 12 (9) (PMID: 32854355) (doi:10.3390/cancers12092413)
15 Aug | 2020 Comparative Study of Organoids from Patient-Derived Normal and Tumor Colon and Rectal Tissue. Costales-Carrera, A , Fernández-Barral, A , Bustamante-Madrid, P , Domínguez, O, Guerra-Pastrián, L, Cantero, R, Del Peso, L , Burgos, A, Barbáchano, A , Muñoz, A . Cancers (Basel) - 12 (8) (PMID: 32824266) (doi:10.3390/cancers12082302)
1 Jan | 2020 Vitamin D differentially regulates colon stem cells in patient-derived normal and tumor organoids. Fernández-Barral, A , Costales-Carrera, A , Buira, SP, Jung, P, Ferrer-Mayorga, G , Larriba, MJ , Bustamante-Madrid, P , Domínguez, O, Real, FX, Guerra-Pastrián, L, Lafarga, M, García-Olmo, D, Cantero, R, Del Peso, L , Batlle, E, Rojo, F, Muñoz, A , Barbáchano, A . FEBS J. - 287 (1) : 53-72 (PMID: 31306552) (doi:10.1111/febs.14998)
26 Dec | 2019 Fibroblast-Derived 3D Matrix System Applicable to Endothelial Tube Formation Assay. Galindo-Pumariño, C, Herrera, A, Muñoz, A , Carrato, A, Herrera, M, Peña, C. J Vis Exp (PMID: 31929503) (doi:10.3791/60304)
19 Nov | 2019 Plocabulin Displays Strong Cytotoxic Activity in a Personalized Colon Cancer Patient-Derived 3D Organoid Assay. Costales-Carrera, A , Fernández-Barral, A , Bustamante-Madrid, P , Guerra, L, Cantero, R, Barbáchano, A , Muñoz, A . Mar Drugs - 17 (11) (PMID: 31752287) (doi:10.3390/md17110648)
27 Sep | 2019 Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity. Santos, CP, Lapi, E, Martínez de Villarreal, J, Álvaro-Espinosa, L, Fernández-Barral, A , Barbáchano, A , Domínguez, O, Laughney, AM, Megías, D, Muñoz, A , Real, FX. Nat Commun - 10 (1) : 4407 (PMID: 31562298) (doi:10.1038/s41467-019-12307-1)
30 May | 2019 Vitamin D and Wnt3A have additive and partially overlapping modulatory effects on gene expression and phenotype in human colon fibroblasts. Ferrer-Mayorga, G , Niell, N , Cantero, R, González-Sancho, JM , Del Peso, L , Muñoz, A , Larriba, MJ . Sci Rep - 9 (1) : 8085 (PMID: 31147591) (doi:10.1038/s41598-019-44574-9)
1 Jan | 2019 Mechanisms of action of vitamin D in colon cancer. Ferrer-Mayorga, G , Larriba, MJ , Crespo, P , Muñoz, A . J. Steroid Biochem. Mol. Biol. - 185 : 1-6 (PMID: 29981368) (doi:10.1016/j.jsbmb.2018.07.002)
24 Sep | 2018 Endothelial cell activation on 3D-matrices derived from PDGF-BB-stimulated fibroblasts is mediated by Snail1. Herrera, A, Herrera, M, Guerra-Perez, N, Galindo-Pumariño, C, Larriba, MJ , García-Barberán, V, Gil, B, Giménez-Moyano, S, Ferreiro-Monteagudo, R, Veguillas, P, Candia, A, Peña, R, Pinto, J, García-Bermejo, ML, Muñoz, A , García de Herreros, A, Bonilla, F, Carrato, A, Peña, C. Oncogenesis - 7 (9) : 76 (PMID: 30250018) (doi:10.1038/s41389-018-0085-z)
29 Jun | 2018 Aryl Hydrocarbon Receptor Promotes Liver Polyploidization and Inhibits PI3K, ERK, and Wnt/β-Catenin Signaling. Moreno-Marín, N, Merino, JM, Alvarez-Barrientos, A, Patel, DP, Takahashi, S, González-Sancho, JM , Gandolfo, P, Rios, RM, Muñoz, A , Gonzalez, FJ, Fernández-Salguero, PM. iScience - 4 : 44-63 (PMID: 30240752) (doi:10.1016/j.isci.2018.05.006)
15 Feb | 2018 The human PKP2/plakophilin-2 gene is induced by Wnt/β-catenin in normal and colon cancer-associated fibroblasts. Niell, N , Larriba, MJ , Ferrer-Mayorga, G , Sánchez-Pérez, I , Cantero, R, Real, FX, Del Peso, L , Muñoz, A , González-Sancho, JM . Int. J. Cancer - 142 (4) : 792-804 (PMID: 29044515) (doi:10.1002/ijc.31104)
15 Sep | 2017 The endocrine vitamin D system in the gut. Barbáchano, A , Fernández-Barral, A , Ferrer-Mayorga, G , Costales-Carrera, A , Larriba, MJ , Muñoz, A . Mol. Cell. Endocrinol. - 453 : 79-87 (PMID: 27913273) (doi:10.1016/j.mce.2016.11.028)
1 Aug | 2017 Vitamin D receptor expression and associated gene signature in tumour stromal fibroblasts predict clinical outcome in colorectal cancer. Ferrer-Mayorga, G , Gómez-López, G, Barbáchano, A , Fernández-Barral, A , Peña, C, Pisano, DG, Cantero, R, Rojo, F, Muñoz, A , Larriba, MJ . Gut - 66 (8) : 1449-1462 (PMID: 27053631) (doi:10.1136/gutjnl-2015-310977)
6 Oct | 2016 Twist1-induced activation of human fibroblasts promotes matrix stiffness by upregulating palladin and collagen α1(VI). García-Palmero, I , Torres, S, Bartolomé, RA, Peláez-García, A, Larriba, MJ , Lopez-Lucendo, M, Peña, C , Escudero-Paniagua, B, Muñoz, A , Casal, JI. Oncogene - 35 (40) : 5224-5236 (PMID: 26973246) (doi:10.1038/onc.2016.57)
28 Jul | 2016 PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes. Anta, B, Pérez-Rodríguez, A, Castro, J, García-Domínguez, CA, Ibiza, S, Martínez, N, Durá, LM, Hernández, S, Gragera, T, Peña-Jiménez, D, Yunta, M, Zarich, N, Crespo, P , Serrador, JM, Santos, E, Muñoz, A , Oliva, JL, Rojas-Cabañeros, JM. Cell Death Dis - 7 (7) : e2311 (PMID: 27468687) (doi:10.1038/cddis.2016.219)
9 Jun | 2016 SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150. Barbáchano, A , Fernández-Barral, A , Pereira, F, Segura, MF, Ordóñez-Morán, P , Carrillo-de Santa Pau, E, González-Sancho, JM , Hanniford, D, Martínez, N, Costales-Carrera, A, Real, FX, Pálmer, HG , Rojas, JM, Hernando, E, Muñoz, A . Oncogene - 35 (23) : 2991-3003 (PMID: 26455323) (doi:10.1038/onc.2015.366)
6 Jan | 2016 Vitamin D and the Epithelial to Mesenchymal Transition. Larriba, MJ , García de Herreros, A, Muñoz, A . Stem Cells Int - 2016 : 6213872 (PMID: 26880977) (doi:10.1155/2016/6213872)
13 Sep | 2015 Cystatin D Locates in the Nucleus at Sites of Active Transcription and Modulates Gene and Protein Expression. Ferrer-Mayorga, G , Alvarez-Diaz, S , Valle, N , De Las Rivas, J, Mendes, M, Barderas, R, Canals, F, Tapia, O, Casal, JI, Lafarga, M, Munoz, A . J. Biol. Chem. (PMID: 26364852) (doi:10.1074/jbc.M115.660175)
20 Mar | 2015 Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer. Aguilera, Ó, González-Sancho, JM , Zazo, S, Rincón, R, Fernández, AF, Tapia, O, Canals, F, Morte, B , Calvanese, V, Orgaz, JL , Niell, N , Aguilar, S, Freije, JM, Graña, O, Pisano, DG, Borrero, A, Martínez-Useros, J, Jiménez, B , Fraga, MF, García-Foncillas, J, López-Otín, C, Lafarga, M, Rojo, F, Muñoz, A . Oncotarget - 6 (8) : 5903-5917 (PMID: 25788273) (doi:10.18632/oncotarget.3464)
1 May | 2014 Snail1 expression is required for sarcomagenesis. Alba-Castellón, L, Batlle, R, Francí, C, Fernández-Aceñero, MJ, Mazzolini, R, Peña, R, Loubat, J, Alameda, F, Rodríguez, R , Curto, J, Albanell, J, Muñoz, A , Bonilla, F, Ignacio Casal, J, Rojo, F, García de Herreros, A. Neoplasia - 16 (5) : 413-421 (PMID: 24947186) (doi:10.1016/j.neo.2014.05.002)
10 Apr | 2014 SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer. Ordóñez-Morán, P , Irmisch, A, Barbáchano, A , Chicote, I, Tenbaum, S, Landolfi, S, Tabernero, J, Huelsken, J, Muñoz, A , Pálmer, HG . Oncogene - 33 (15) : 1975-1985 (PMID: 23624922) (doi:10.1038/onc.2013.140)
18 Feb | 2014 Interaction of vitamin D with membrane-based signaling pathways. Larriba, MJ , González-Sancho, JM , Bonilla, F, Muñoz, A . Front Physiol - 5 : 60 (PMID: 24600406) (doi:10.3389/fphys.2014.00060)
21 Oct | 2013 Vitamin D Is a Multilevel Repressor of Wnt/b-Catenin Signaling in Cancer Cells. Larriba, MJ , González-Sancho, JM , Barbáchano, A , Niell, N , Ferrer-Mayorga, G , Muñoz, A . Cancers (Basel) - 5 (4) : 1242-1260 (PMID: 24202444) (doi:10.3390/cancers5041242)
21 May | 2013 c-Jun N-terminal kinase phosphorylation is a biomarker of plitidepsin activity. Muñoz-Alonso, MJ , Álvarez, E, Guillén-Navarro, MJ, Pollán, M, Avilés, P, Galmarini, CM, Muñoz, A . Mar Drugs - 11 (5) : 1677-1692 (PMID: 23697951) (doi:10.3390/md11051677)
19 Dec | 2012 Plasma 25-hydroxyvitamin D(3) and bladder cancer risk according to tumor stage and FGFR3 status: a mechanism-based epidemiological study. Amaral, AF, Méndez-Pertuz, M, Muñoz, A , Silverman, DT, Allory, Y, Kogevinas, M, Lloreta, J, Rothman, N, Carrato, A, Rivas del Fresno, M, Real, FX, Malats, N, , . J. Natl. Cancer Inst. - 104 (24) : 1897-1904 (PMID: 23108201) (doi:10.1093/jnci/djs444)
25 Oct | 2012 Synthesis and biological evaluation of 1α,25-dihydroxyvitamin D₃ analogues with a long side chain at C12 and short C17 side chains. Carballa, DM, Seoane, S, Zacconi, F, Pérez, X, Rumbo, A, Alvarez-Díaz, S , Larriba, MJ , Pérez-Fernández, R, Muñoz, A , Maestro, M, Mouriño, A, Torneiro, M. J. Med. Chem. - 55 (20) : 8642-8656 (PMID: 22989379) (doi:10.1021/jm3008272)
1 Jun | 2012 Vitamin D and colon cancer. Pereira, F , Larriba, MJ , Muñoz, A . Endocr. Relat. Cancer - 19 (3) : R51-71 (PMID: 22383428) (doi:10.1530/ERC-11-0388)
1 Jun | 2012 β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer. Tenbaum, SP , Ordóñez-Morán, P , Puig, I, Chicote, I, Arqués, O, Landolfi, S, Fernández, Y, Herance, JR, Gispert, JD, Mendizabal, L, Aguilar, S, Ramón y Cajal, S, Schwartz, S, Vivancos, A, Espín, E, Rojas, S, Baselga, J, Tabernero, J, Muñoz, A , Palmer, HG . Nat. Med. - 18 (6) : 892-901 (PMID: 22610277) (doi:10.1038/nm.2772)
15 May | 2012 MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells. Alvarez-Díaz, S , Valle, N , Ferrer-Mayorga, G , Lombardía, L, Herrera, M, Domínguez, O, Segura, MF, Bonilla, F, Hernando, E, Muñoz, A . Hum. Mol. Genet. - 21 (10) : 2157-2165 (PMID: 22328083) (doi:10.1093/hmg/dds031)
15 Mar | 2012 Vitamin D has wide regulatory effects on histone demethylase genes. Pereira, F , Barbáchano, A , Singh, PK, Campbell, MJ, Muñoz, A , Larriba, MJ . Cell Cycle - 11 (6) : 1081-1089 (PMID: 22370479) (doi:10.4161/cc.11.6.19508)
9 Jan | 2012 Design, synthesis, evaluation, and structure of vitamin D analogues with furan side chains. Fraga, R, Zacconi, F, Sussman, F, Ordóñez-Morán, P , Muñoz, A , Huet, T, Molnár, F, Moras, D, Rochel, N, Maestro, M, Mouriño, A. Chemistry - 18 (2) : 603-612 (PMID: 22162241) (doi:10.1002/chem.201102695)
21 Dec | 2011 Proteomic analysis of 1α,25-dihydroxyvitamin D3 action on human colon cancer cells reveals a link to splicing regulation. Cristobo, I, Larriba, MJ , de los Ríos, V, García, F, Muñoz, A , Casal, JI. J Proteomics - 75 (2) : 384-397 (PMID: 21864731) (doi:10.1016/j.jprot.2011.08.003)
1 Dec | 2011 KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells. Pereira, F , Barbáchano, A , Silva, J, Bonilla, F, Campbell, MJ, Muñoz, A , Larriba, MJ . Hum. Mol. Genet. - 20 (23) : 4655-4665 (PMID: 21890490) (doi:10.1093/hmg/ddr399)
15 Aug | 2011 Vitamin D receptor deficiency enhances Wnt/β-catenin signaling and tumor burden in colon cancer. Larriba, MJ , Ordóñez-Morán, P , Chicote, I, Martín-Fernández, G , Puig, I, Muñoz, A , Pálmer, HG . PLoS ONE - 6 (8) : e23524 (PMID: 21858154) (doi:10.1371/journal.pone.0023524)
9 Jun | 2011 Synthesis and biological evaluation of 1α,25-dihydroxyvitamin D(3) analogues hydroxymethylated at C-26. Regueira, MA, Samanta, S, Malloy, PJ, Ordonez-Moran, P , Resende, D, Sussman, F, Munoz, A , Mourino, A, Feldman, D, Torneiro, M. J. Med. Chem. - 54 (11) : 3950-3962 (PMID: 21524075) (doi:10.1021/jm200276y)
2 May | 2011 Synthesis, structure, and biological activity of des-side chain analogues of 1α,25-dihydroxyvitamin D3 with substituents at C18. Verlinden, L, Verstuyf, A, Eelen, G, Bouillon, R, Ordóñez-Morán, P , Larriba, MJ , Muñoz, A , Rochel, N, Sato, Y, Moras, D, Maestro, M, Seoane, S, Dominguez, F, Eduardo-Canosa, S, Nicoletti, D, Moman, E, Mouriño, A. ChemMedChem - 6 (5) : 788-793 (PMID: 21520419) (doi:10.1002/cmdc.201100021)
1 Oct | 2010 Site-dependent E-cadherin cleavage and nuclear translocation in a metastatic colorectal cancer model. Céspedes, MV, Larriba, MJ , Pavón, MA, Alamo, P, Casanova, I, Parreño, M, Feliu, A, Sancho, FJ, Muñoz, A , Mangues, R. Am. J. Pathol. - 177 (4) : 2067-2079 (PMID: 20813963) (doi:10.2353/ajpath.2010.100079)
26 Aug | 2010 SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity. Barbáchano, A , Ordóñez-Morán, P , García, JM , Sánchez, A, Pereira, F, Larriba, MJ , Martínez, N, Hernández, J, Landolfi, S, Bonilla, F, Pálmer, HG , Rojas, JM, Muñoz, A . Oncogene - 29 (34) : 4800-4813 (PMID: 20543868) (doi:10.1038/onc.2010.225)
19 Jul | 2010 CD-ring modified vitamin D3 analogs and their superagonistic action. Eelen, G, Verlinden, L, Bouillon, R, De Clercq, P, Muñoz, A , Verstuyf, A. J. Steroid Biochem. Mol. Biol. - 121 (1-2) : 417-419 (PMID: 20132886) (doi:10.1016/j.jsbmb.2010.01.010)
19 Jul | 2010 The effects of 1,25-dihydroxyvitamin D3 on colon cancer cells depend on RhoA-ROCK-p38MAPK-MSK signaling. Ordóñez-Morán, P , Alvarez-Díaz, S , Valle, N , Larriba, MJ , Bonilla, F, Muñoz, A . J. Steroid Biochem. Mol. Biol. - 121 (1-2) : 355-361 (PMID: 20223287) (doi:10.1016/j.jsbmb.2010.02.031)
19 Jul | 2010 The transcription factors Snail1 and Snail2 repress vitamin D receptor during colon cancer progression. Larriba, MJ , Bonilla, F, Muñoz, A . J. Steroid Biochem. Mol. Biol. - 121 (1-2) : 106-109 (PMID: 20138990) (doi:10.1016/j.jsbmb.2010.01.014)
1 Jul | 2010 Epigenetics and environment: a complex relationship. Aguilera, O , Fernández, AF, Muñoz, A , Fraga, MF. J. Appl. Physiol. - 109 (1) : 243-251 (PMID: 20378707) (doi:10.1152/japplphysiol.00068.2010)
30 Jun | 2010 Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer. Lara, E, Calvanese, V, Huidobro, C, Fernández, AF, Moncada-Pazos, A, Obaya, AJ, Aguilera, O , González-Sancho, JM , Sánchez, L, Astudillo, A, Muñoz, A , López-Otín, C, Esteller, M, Fraga, MF. Mol. Cancer - 9 : 170 (PMID: 20591152) (doi:10.1186/1476-4598-9-170)
20 Apr | 2010 Novel snail1 target proteins in human colon cancer identified by proteomic analysis. Larriba, MJ , Casado-Vela, J , Pendás-Franco, N , Peña, R, García de Herreros, A, Berciano, MT, Lafarga, M, Casal, JI, Muñoz, A . PLoS ONE - 5 (4) : e10221 (PMID: 20421926) (doi:10.1371/journal.pone.0010221)
1 Jan | 2010 Vitamin D: Proteases, protease inhibitors and cancer. Alvarez-Díaz, S , Larriba, MJ , López-Otín, C, Muñoz, A . Cell Cycle - 9 (1) : 32-37 (PMID: 20016282)
10 Dec | 2009 SNAI1 expression in colon cancer related with CDH1 and VDR downregulation in normal adjacent tissue. Peña, C , García, JM , Larriba, MJ , Barderas, R, Gómez, I, Herrera, M, García, V, Silva, J, Domínguez, G , Rodríguez, R, Cuevas, J, de Herreros, AG, Casal, JI, Muñoz, A , Bonilla, F. Oncogene - 28 (49) : 4375-4385 (PMID: 19802011) (doi:10.1038/onc.2009.285)
27 Aug | 2009 Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells. Alvarez-Díaz, S , Valle, N , García, JM , Peña, C, Freije, JM, Quesada, V, Astudillo, A, Bonilla, F, López-Otín, C, Muñoz, A . J. Clin. Invest. - 119 (8) : 2343-2358 (PMID: 19662683)
1 Aug | 2009 Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer. Larriba, MJ , Martín-Villar, E , García, JM , Pereira, F , Peña, C, de Herreros, AG, Bonilla, F, Muñoz, A . Carcinogenesis - 30 (8) : 1459-1468 (PMID: 19502595) (doi:10.1093/carcin/bgp140)
10 Jun | 2009 The mechanism of action of plitidepsin. Muñoz-Alonso, MJ , González-Santiago, L , Martínez, T , Losada, A , Galmarini, CM, Muñoz, A . Curr Opin Investig Drugs - 10 (6) : 536-542 (PMID: 19513942)
1 Jun | 2009 Nuclear receptors: genomic and non-genomic effects converge. Ordóñez-Morán, P , Muñoz, A . Cell Cycle - 8 (11) : 1675-1680 (PMID: 19448403)
1 Jan | 2009 Combination of polymorphisms within 5' and 3' untranslated regions of thymidylate synthase gene modulates survival in 5 fluorouracil-treated colorectal cancer patients. Fernández-Contreras, ME, Sánchez-Hernández, JJ, González, E, Herráez, B, Domínguez, I, Lozano, M, García De Paredes, ML, Muñoz, A , Gamallo, C . Int. J. Oncol. - 34 (1) : 219-229 (PMID: 19082493)
16 Dec | 2008 Vitamin D and Wnt/beta-catenin pathway in colon cancer: role and regulation of DICKKOPF genes. Pendás-Franco, N , Aguilera, O , Pereira, F , González-Sancho, JM , Muñoz, A . Anticancer Res. - 28 (5A) : 2613-2623 (PMID: 19035286)
17 Nov | 2008 RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells. Ordóñez-Morán, P , Larriba, MJ , Pálmer, HG , Valero, RA, Barbáchano, A , Duñach, M, de Herreros, AG, Villalobos, C, Berciano, MT, Lafarga, M, Muñoz, A . J. Cell Biol. - 183 (4) : 697-710 (PMID: 19015318) (doi:10.1083/jcb.200803020)
20 Oct | 2008 Superagonistic fluorinated vitamin D3 analogs stabilize helix 12 of the vitamin D receptor. Eelen, G, Valle, N , Sato, Y, Rochel, N, Verlinden, L, De Clercq, P, Moras, D, Bouillon, R, Muñoz, A , Verstuyf, A. Chem. Biol. - 15 (10) : 1029-1034 (PMID: 18940664) (doi:10.1016/j.chembiol.2008.08.008)
24 Jul | 2008 DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3. Pendás-Franco, N , García, JM , Peña, C , Valle, N , Pálmer, HG , Heinäniemi, M, Carlberg, C, Jiménez, B , Bonilla, F, Muñoz, A , González-Sancho, JM . Oncogene - 27 (32) : 4467-4477 (PMID: 18408752) (doi:10.1038/onc.2008.88)
10 Jul | 2008 Vitamin D3 and colorectal cancer. Larriba, MJ , Valle, N , Alvarez, S , Muñoz, A . Adv. Exp. Med. Biol. - 617 : 271-280 (PMID: 18497050) (doi:10.1007/978-0-387-69080-3_25)
1 Jul | 2008 E-cadherin controls beta-catenin and NF-kappaB transcriptional activity in mesenchymal gene expression. Solanas, G, Porta-de-la-Riva, M, Agustí, C, Casagolda, D, Sánchez-Aguilera, F, Larriba, MJ , Pons, F, Peiró, S, Escrivà, M, Muñoz, A , Duñach, M, de Herreros, AG, Baulida, J. J. Cell. Sci. - 121 (Pt 13) : 2224-2234 (PMID: 18565826) (doi:10.1242/jcs.021667)
24 Mar | 2008 Plitidepsin has a dual effect inhibiting cell cycle and inducing apoptosis via Rac1/c-Jun NH2-terminal kinase activation in human melanoma cells. Muñoz-Alonso, MJ , González-Santiago, L , Zarich, N, Martínez, T , Alvarez, E, Rojas, JM, Muñoz, A . J. Pharmacol. Exp. Ther. - 324 (3) : 1093-1101 (PMID: 18089842) (doi:10.1124/jpet.107.132662)
28 Sep | 2007 The Wnt antagonist DICKKOPF-1 gene is induced by 1alpha,25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells. Aguilera, O , Peña, C, García, JM , Larriba, MJ , Ordóñez-Morán, P , Navarro, D , Barbáchano, A , López de Silanes, I, Ballestar, E, Fraga, MF, Esteller, M, Gamallo, C , Bonilla, F, González-Sancho, JM , Muñoz, A . Carcinogenesis - 28 (9) : 1877-1884 (PMID: 17449905) (doi:10.1093/carcin/bgm094)
9 Apr | 2007 Proteomic analysis of the resistance to aplidin in human cancer cells. González-Santiago, L , Alfonso, P, Suárez, Y , Núñez, A, García-Fernández, LF , Alvarez, E, Muñoz, A , Casal, JI. J. Proteome Res. - 6 (4) : 1286-1294 (PMID: 17338558) (doi:10.1021/pr060430+)
30 Mar | 2007 The inhibition of Wnt/beta-catenin signalling by 1alpha,25-dihydroxyvitamin D3 is abrogated by Snail1 in human colon cancer cells. Larriba, MJ , Valle, N , Pálmer, HG , Ordóñez-Morán, P , Alvarez-Díaz, S , Becker, KF, Gamallo, C , de Herreros, AG, González-Sancho, JM , Muñoz, A . Endocr. Relat. Cancer - 14 (1) : 141-151 (PMID: 17395983) (doi:10.1677/ERC-06-0028)
15 Mar | 2007 Vitamin D regulates the phenotype of human breast cancer cells. Pendás-Franco, N , González-Sancho, JM , Suárez, Y , Aguilera, O , Steinmeyer, A, Gamallo, C , Berciano, MT, Lafarga, M, Muñoz, A . Differentiation - 75 (3) : 193-207 (PMID: 17288543) (doi:10.1111/j.1432-0436.2006.00131.x)
9 Mar | 2007 Epigenetic alterations of the Wnt/beta-catenin pathway in human disease. Aguilera, O , Muñoz, A , Esteller, M, Fraga, MF. Endocr Metab Immune Disord Drug Targets - 7 (1) : 13-21 (PMID: 17346200)
21 Nov | 2006 Aplidin induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation. González-Santiago, L, Suárez, Y , Zarich, N, Muñoz-Alonso, MJ , Cuadrado, A , Martínez, T , Goya, L, Iradi, A, Sáez-Tormo, G, Maier, JV, Moorthy, A, Cato, AC, Rojas, JM, Muñoz, A . Cell Death Differ. - 13 (11) : 1968-1981 (PMID: 16543941) (doi:10.1038/sj.cdd.4401898)
1 Nov | 2006 Plitidepsin cellular binding and Rac1/JNK pathway activation depend on membrane cholesterol content. Suárez, Y , González-Santiago, L , Zarich, N, Dávalos, A, Aranda, JF, Alonso, MA, Lasunción, MA, Rojas, JM, Muñoz, A . Mol. Pharmacol. - 70 (5) : 1654-1663 (PMID: 16928956) (doi:10.1124/mol.106.025569)
1 Nov | 2006 The expression levels of the transcriptional regulators p300 and CtBP modulate the correlations between SNAIL, ZEB1, E-cadherin and vitamin D receptor in human colon carcinomas. Peña, C, García, JM , García, V , Silva, J, Domínguez, G , Rodríguez, R , Maximiano, C, García de Herreros, A, Muñoz, A , Bonilla, F. Int. J. Cancer - 119 (9) : 2098-2104 (PMID: 16804902) (doi:10.1002/ijc.22083)
22 Aug | 2006 Effects of 1alpha,25-dihydroxyvitamin D3 in human colon cancer cells. González-Sancho, JM , Larriba, MJ , Ordóñez-Morán, P , Pálmer, HG , Muñoz, A . Anticancer Res. - 26 (4A) : 2669-2681 (PMID: 16886677)
6 Jul | 2006 Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer. Aguilera, O , Fraga, MF, Ballestar, E, Paz, MF, Herranz, M, Espada, J , García, JM , Muñoz, A , Esteller, M, González-Sancho, JM . Oncogene - 25 (29) : 4116-4121 (PMID: 16491118) (doi:10.1038/sj.onc.1209439)
14 Apr | 2006 Snail1 transcriptional repressor binds to its own promoter and controls its expression. Peiró, S, Escrivà, M, Puig, I, Barberà, MJ, Dave, N, Herranz, N, Larriba, MJ , Takkunen, M, Francí, C, Muñoz, A , Virtanen, I, Baulida, J, García de Herreros, A. Nucleic Acids Res. - 34 (7) : 2077-2084 (PMID: 16617148) (doi:10.1093/nar/gkl141)
15 Nov | 2005 E-cadherin and vitamin D receptor regulation by SNAIL and ZEB1 in colon cancer: clinicopathological correlations. Peña, C, García, JM , Silva, J, García, V , Rodríguez, R , Alonso, I, Millán, I, Salas, C, de Herreros, AG, Muñoz, A , Bonilla, F. Hum Mol Genet - 14 (22) : 3361-3370 (PMID: 16203744) (doi:10.1093/hmg/ddi366)
29 Sep | 2005 1alpha,25-Dihydroxyvitamin D3 regulates the expression of Id1 and Id2 genes and the angiogenic phenotype of human colon carcinoma cells. Fernandez-Garcia, NI , Palmer, HG , Garcia, M, Gonzalez-Martin, A , del Rio, M, Barettino, D , Volpert, O, Muñoz, A , Jimenez, B . Oncogene - 24 (43) : 6533-6544 (PMID: 16007183) (doi:10.1038/sj.onc.1208801)
1 Sep | 2005 Vitamin D and cancer: an update of in vitro and in vivo data. Ordonez-Moran, P , Larriba, MJ , Pendas-Franco, N , Aguilera, O , Gonzalez-Sancho, JM , Munoz, A . Front. Biosci. - 10 : 2723-2749 (PMID: 15970529)
19 Aug | 2005 Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism. Fu, M, Wang, C, Rao, M, Wu, X, Bouras, T, Zhang, X, Li, Z, Jiao, X, Yang, J, Li, A, Perkins, ND, Thimmapaya, B, Kung, AL, Munoz, A , Giordano, A, Lisanti, MP, Pestell, RG. J Biol Chem - 280 (33) : 29728-29742 (PMID: 15951563) (doi:10.1074/jbc.M503188200)
5 Jul | 2005 Postnatal thyroid hormone supplementation rescues developmental abnormalities induced by congenital-neonatal hypothyroidism in the rat retina. Pinazo-Durán, MD, Iborra, FJ, Pons, S, Sevilla-Romero, E, Gallego-Pinazo, R, Muñoz, A . Ophthalmic Res. - 37 (4) : 225-234 (PMID: 16006782) (doi:10.1159/000086863)
28 Mar | 2005 SNAIL vs vitamin D receptor expression in colon cancer: therapeutics implications. Larriba, MJ , Muñoz, A . Br. J. Cancer - 92 (6) : 985-989 (PMID: 15770204) (doi:10.1038/sj.bjc.6602484)
3 Feb | 2005 The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer. González-Sancho, JM , Aguilera, O , García, JM , Pendás-Franco, N , Peña, C, Cal, S, García de Herreros, A, Bonilla, F, Muñoz, A . Oncogene - 24 (6) : 1098-1103 (PMID: 15592505) (doi:10.1038/sj.onc.1208303)
1 Sep | 2004 The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer. Pálmer, HG , Larriba, MJ , García, JM , Ordóñez-Morán, P , Peña, C, Peiró, S, Puig, I, Rodríguez, R , de la Fuente, R, Bernad, A, Pollán, M, Bonilla, F, Gamallo, C , de Herreros, AG, Muñoz, A . Nat. Med. - 10 (9) : 917-919 (PMID: 15322538) (doi:10.1038/nm1095)
10 Jun | 2004 JNK activation is critical for Aplidin-induced apoptosis. Cuadrado, A , González, L , Suárez, Y , Martínez, T , Muñoz, A . Oncogene - 23 (27) : 4673-4680 (PMID: 15122339) (doi:10.1038/sj.onc.1207636)
7 Apr | 2004 Neuroserpin is post-transcriptionally regulated by thyroid hormone. Navarro-Yubero, C , Cuadrado, A , Sonderegger, P, Muñoz, A . Brain Res. Mol. Brain Res. - 123 (1-2) : 56-65 (PMID: 15046866) (doi:10.1016/j.molbrainres.2003.12.018)
31 Dec | 2003 Mixed lineage kinase 2 enhances trans-repression of Alien and nuclear receptors. Eckey, M, Tenbaum, SP , Muñoz, A , Baniahmad, A. Mol. Cell. Endocrinol. - 213 (1) : 71-78 (PMID: 15062575) (doi:10.1016/j.mce.2003.10.035)
17 Nov | 2003 Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids. Bruna, A, Nicolàs, M, Muñoz, A , Kyriakis, JM, Caelles, C. EMBO J. - 22 (22) : 6035-6044 (PMID: 14609950) (doi:10.1093/emboj/cdg590)
15 Nov | 2003 Genetic signatures of differentiation induced by 1alpha,25-dihydroxyvitamin D3 in human colon cancer cells. Pálmer, HG , Sánchez-Carbayo, M, Ordóñez-Morán, P , Larriba, MJ , Cordón-Cardó, C, Muñoz, A . Cancer Res. - 63 (22) : 7799-7806 (PMID: 14633706)
30 Oct | 2003 The first locked side-chain analogues of calcitriol (1alpha,25-dihydroxyvitamin D3) induce vitamin D receptor transcriptional activity. Pérez-García, X, Rumbo, A, Larriba, MJ , Ordóñez, P , Muñoz, A , Mouriño, A. Org. Lett. - 5 (22) : 4033-4036 (PMID: 14572242) (doi:10.1021/ol0351246)
1 Sep | 2003 Kahalalide F, a new marine-derived compound, induces oncosis in human prostate and breast cancer cells. Suárez, Y , González, L , Cuadrado, A , Berciano, M, Lafarga, M, Muñoz, A . Mol. Cancer Ther. - 2 (9) : 863-872 (PMID: 14555705)
1 Aug | 2003 Neuronal HuD gene encoding a mRNA stability regulator is transcriptionally repressed by thyroid hormone. Cuadrado, A , Navarro-Yubero, C , Furneaux, H, Muñoz, A . J. Neurochem. - 86 (3) : 763-773 (PMID: 12859688)
1 Jul | 2003 Role of HuR in skeletal myogenesis through coordinate regulation of muscle differentiation genes. Figueroa, A , Cuadrado, A , Fan, J, Atasoy, U, Muscat, GE, Muñoz-Canoves, P, Gorospe, M, Muñoz, A . Mol. Cell. Biol. - 23 (14) : 4991-5004 (PMID: 12832484)
31 Mar | 2003 Thyroid hormone receptors/THR genes in human cancer. González-Sancho, JM , García, V , Bonilla, F, Muñoz, A . Cancer Lett. - 192 (2) : 121-132 (PMID: 12668276)
1 Feb | 2003 Alien/CSN2 gene expression is regulated by thyroid hormone in rat brain. Tenbaum, SP , Juenemann, S, Schlitt, T, Bernal, J , Renkawitz, R, Muñoz, A , Baniahmad, A. Dev. Biol. - 254 (1) : 149-160 (PMID: 12606288)
3 Jan | 2003 Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK. Cuadrado, A , Garcia-Fernandez, LF , Gonzalez, L, Suarez, Y, Losada, A , Alcaide, V, Martinez, T, Fernandez-Sousa, JM, Sanchez-Puelles, JM, Munoz, A . J. Biol. Chem. - 278 (1) : 241-250 (PMID: 12414812) (doi:10.1074/jbc.M201010200)
20 Nov | 2002 Low thyroid hormone levels impair the perinatal development of the rat retina. Sevilla-Romero, E, Muñoz, A , Pinazo-Durán, MD. Ophthalmic Res. - 34 (4) : 181-191 (PMID: 12297689) (doi:63885)
24 Oct | 2002 Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta. García-Fernández, LF , Losada, A , Alcaide, V, Alvarez, AM, Cuadrado, A , González, L , Nakayama, K, Nakayama, KI, Fernández-Sousa, JM, Muñoz, A , Sánchez-Puelles, JM. Oncogene - 21 (49) : 7533-7544 (PMID: 12386816) (doi:10.1038/sj.onc.1205972)
1 Oct | 2002 Glucocorticoid receptor antagonism of AP-1 activity by inhibition of MAPK family. Caelles, C , Bruna, A, Morales, M, González-Sancho, JM , González, MV , Jiménez, B , Muñoz, A . Ernst Schering Res. Found. Workshop (PMID: 12355714)
20 Jun | 2002 Expression of thyroid hormone receptor/erbA genes is altered in human breast cancer. Silva, JM, Domínguez, G , González-Sancho, JM , García, JM, Silva, J, García-Andrade, C, Navarro, A, Muñoz, A , Bonilla, F. Oncogene - 21 (27) : 4307-4316 (PMID: 12082618) (doi:10.1038/sj.onc.1205534)
1 Jun | 2002 Regulation of tau RNA maturation by thyroid hormone is mediated by the neural RNA-binding protein musashi-1. Cuadrado, A , García-Fernández, LF , Imai, T, Okano, H, Muñoz, A . Mol. Cell. Neurosci. - 20 (2) : 198-210 (PMID: 12093154)
15 May | 2002 HuD binds to three AU-rich sequences in the 3'-UTR of neuroserpin mRNA and promotes the accumulation of neuroserpin mRNA and protein. Cuadrado, A , Navarro-Yubero, C , Furneaux, H, Kinter, J, Sonderegger, P, Muñoz, A . Nucleic Acids Res. - 30 (10) : 2202-2211 (PMID: 12000840)
1 May | 2002 Inhibition of proliferation and expression of T1 and cyclin D1 genes by thyroid hormone in mammary epithelial cells. González-Sancho, JM , Figueroa, A , López-Barahona, M, López, E, Beug, H, Muñoz, A . Mol. Carcinog. - 34 (1) : 25-34 (PMID: 12112320) (doi:10.1002/mc.10046)
10 Dec | 2001 Role of thyroid hormone in craniofacial and eye development using a rat model. Gamborino, MJ, Sevilla-Romero, E, Muñoz, A , Hernández-Yago, J, Renau-Piqueras, J, Pinazo-Durán, MD. Ophthalmic Res. - 33 (5) : 283-291 (PMID: 11586062) (doi:55682)
1 Oct | 2001 Thyroid hormone regulates TAG-1 expression in the developing rat brain. Alvarez-Dolado, M , Figueroa, A, Kozlov, S, Sonderegger, P, Furley, AJ, Muñoz, A . Eur. J. Neurosci. - 14 (8) : 1209-1218 (PMID: 11703450)
23 Jul | 2001 Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. Pálmer, HG , González-Sancho, JM , Espada, J , Berciano, MT, Puig, I, Baulida, J, Quintanilla, M , Cano, A , de Herreros, AG, Lafarga, M, Muñoz, A . J. Cell Biol. - 154 (2) : 369-387 (PMID: 11470825)
20 Jun | 2001 Thyroid hormone regulates the obesity gene tub. Koritschoner, NP, Alvarez-Dolado, M , Kurz, SM, Heikenwälder, MF, Hacker, C, Vogel, F, Muñoz, A , Zenke, M. EMBO Rep. - 2 (6) : 499-504 (PMID: 11415982) (doi:10.1093/embo-reports/kve107)
7 Jun | 2001 c-Jun N-terminal kinase activation is required for the inhibition of neovascularization by thrombospondin-1. Jiménez, B , Volpert, OV, Reiher, F, Chang, L, Muñoz, A , Karin, M, Bouck, N. Oncogene - 20 (26) : 3443-3448 (PMID: 11423995) (doi:10.1038/sj.onc.1204464)
1 Mar | 2001 Effect of hypothyroidism on G protein-coupled receptor kinase 2 expression levels in rat liver, lung, and heart. Penela, P, Barradas, M, Alvarez-Dolado, M , Muñoz, A , Mayor, F. Endocrinology - 142 (3) : 987-991 (PMID: 11181510) (doi:10.1210/endo.142.3.8039)
1 Oct | 2000 Regulation of the L1 cell adhesion molecule by thyroid hormone in the developing brain. Alvarez-Dolado, M , Cuadrado, A , Navarro-Yubero, C , Sonderegger, P, Furley, AJ, Bernal, J , Muñoz, A . Mol. Cell. Neurosci. - 16 (4) : 499-514 (PMID: 11085884) (doi:10.1006/mcne.2000.0879)
4 Sep | 2000 Glucocorticoids antagonize AP-1 by inhibiting the Activation/phosphorylation of JNK without affecting its subcellular distribution. González, MV , Jiménez, B , Berciano, MT, González-Sancho, JM , Caelles, C , Lafarga, M, Muñoz, A . J. Cell Biol. - 150 (5) : 1199-1208 (PMID: 10974006)
17 Aug | 2000 Dexamethasone induces lipocalin-type prostaglandin D synthase gene expression in mouse neuronal cells. García-Fernández, LF , Iñiguez, MA, Eguchi, N, Fresno, M, Urade, Y, Muñoz, A . J. Neurochem. - 75 (2) : 460-470 (PMID: 10899920)
1 Jul | 2000 Expression patterns of the regulatory proteins G protein-coupled receptor kinase 2 and beta-arrestin 1 during rat postnatal brain development: effect of hypothyroidism. Penela, P, Alvarez-Dolado, M , Muñoz, A , Mayor, F. Eur. J. Biochem. - 267 (14) : 4390-4396 (PMID: 10880962)
27 Dec | 1999 Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions. Alvarez-Dolado, M , González-Moreno, M, Valencia, A, Zenke, M, Bernal, J , Muñoz, A . J. Neurochem. - 73 (6) : 2240-2249 (PMID: 10582581)
15 Oct | 1999 Retinoic acid and 1,25-dihydroxyvitamin D3 inhibit tenascin-C expression in rat glioma C6 cells. Alvarez-Dolado, M , González-Sancho, JM , Navarro-Yubero, C , García-Fernández, LF , Muñoz, A . J. Neurosci. Res. - 58 (2) : 293-300 (PMID: 10502285)
8 Oct | 1999 Hormone-activated nuclear receptors inhibit the stimulation of the JNK and ERK signalling pathways in endothelial cells. González, MV , González-Sancho, JM , Caelles, C , Munoz, A , Jiménez, B . FEBS Lett. - 459 (2) : 272-276 (PMID: 10518034)
25 Aug | 1999 Identification of the mammalian homolog of the splicing regulator Suppressor-of-white-apricot as a thyroid hormone regulated gene. Cuadrado, A , Bernal, J , Muñoz, A . Brain Res. Mol. Brain Res. - 71 (2) : 332-340 (PMID: 10521587)
15 Aug | 1999 Thyroid hormone regulates reelin and dab1 expression during brain development. Alvarez-Dolado, M , Ruiz, M, Del Río, JA, Alcántara, S, Burgaya, F, Sheldon, M, Nakajima, K, Bernal, J , Howell, BW, Curran, T, Soriano, E , Muñoz, A . J. Neurosci. - 19 (16) : 6979-6993 (PMID: 10436054)
1 Feb | 1999 Inhibition of tenascin-C expression in mammary epithelial cells by thyroid hormone. González-Sancho, JM , Alvarez-Dolado, M , Caelles, C , Muñoz, A . Mol. Carcinog. - 24 (2) : 99-9107 (PMID: 10078937)
1 Sep | 1998 Vitamin D3 inhibits proliferation and increases c-myc expression in fibroblasts from psoriatic patients. Casado, M, Martin, M, Muñoz, A , Bernal, J . J. Endocrinol. Invest. - 21 (8) : 520-525 (PMID: 9801993)
5 Jun | 1998 The c-erbA alpha protooncogene induces apoptosis in glial cells via a protein kinase C- and bcl-2-suppressible mechanism. Llanos, S, Caelles, C , Azorín, I, Renau-Piqueras, J, Fernández-Luna, JL, Boscá, L , Muñoz, A . J. Neurochem. - 70 (6) : 2315-2326 (PMID: 9603196)
8 May | 1998 Developmental expression of the tenascin-C is altered by hypothyroidism in the rat brain. Alvarez-Dolado, M , González-Sancho, JM , Bernal, J , Muñoz, A . Neuroscience - 84 (1) : 309-322 (PMID: 9580330)
17 Apr | 1998 1,25-Dihydroxyvitamin D3 inhibits tenascin-C expression in mammary epithelial cells. González-Sancho, JM , Alvarez-Dolado, M , Muñoz, A . FEBS Lett. - 426 (2) : 225-228 (PMID: 9599013)
1 Apr | 1998 Identification of a thyroid hormone response element in the promoter region of the rat lipocalin-type prostaglandin D synthase (beta-trace) gene. García-Fernández, LF , Urade, Y, Hayaishi, O, Bernal, J , Muñoz, A . Brain Res. Mol. Brain Res. - 55 (2) : 321-330 (PMID: 9582446)
15 Dec | 1997 Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway. Caelles, C , González-Sancho, JM , Muñoz, A . Genes Dev. - 11 (24) : 3351-3364 (PMID: 9407028)
1 Nov | 1997 Biological activities of thyroid hormone receptors. Muñoz, A , Bernal, J . Eur. J. Endocrinol. - 137 (5) : 433-445 (PMID: 9405018)
1 Aug | 1997 Hypothyroidism alters the expression of prostaglandin D2 synthase/beta trace in specific areas of the developing rat brain. García-Fernández, LF , Rausell, E, Urade, Y, Hayaishi, O, Bernal, J , Muñoz, A . Eur. J. Neurosci. - 9 (8) : 1566-1573 (PMID: 9283811)
1 Dec | 1996 Post-transcriptional induction of beta 1-adrenergic receptor by retinoic acid, but not triiodothyronine, in C6 glioma cells expressing thyroid hormone receptors. López-Barahona, M, Iglesias, T , García-Higuera, I, Mayor, F, Zaballos, A, Bernal, J , Muñoz, A . Eur. J. Endocrinol. - 135 (6) : 709-715 (PMID: 9025717)
15 Aug | 1996 Thyroid hormone-dependent transcriptional repression of neural cell adhesion molecule during brain maturation. Iglesias, T , Caubín, J, Stunnenberg, HG, Zaballos, A, Bernal, J , Muñoz, A . EMBO J. - 15 (16) : 4307-4316 (PMID: 8861959)
1 Mar | 1996 v-erbA oncogene induces invasiveness and anchorage-independent growth in cultured glial cells by mechanisms involving platelet-derived growth factor. Llanos, S, Iglesias, T , Riese, HH, Garrido, T, Caelles, C , Muñoz, A . Cell Growth Differ. - 7 (3) : 373-382 (PMID: 8838867)
25 May | 1995 Identification of the mitochondrial NADH dehydrogenase subunit 3 (ND3) as a thyroid hormone regulated gene by whole genome PCR analysis. Iglesias, T , Caubín, J, Zaballos, A, Bernal, J , Muñoz, A . Biochem. Biophys. Res. Commun. - 210 (3) : 995-991000 (PMID: 7763274)
16 Mar | 1995 Induction of platelet-derived growth factor B/c-sis by the v-erbA oncogene in glial cells. Iglesias, T , Llanos, S, López-Barahona, M, Seliger, B, Rodríguez-Peña, A , Bernal, J , Muñoz, A . Oncogene - 10 (6) : 1103-1110 (PMID: 7700635)
15 Mar | 1995 Thyroid hormone regulates stromelysin expression, protease secretion and the morphogenetic potential of normal polarized mammary epithelial cells. López-Barahona, M, Fialka, I, González-Sancho, JM , Asunción, M , González, M, Iglesias, T , Bernal, J , Beug, H, Muñoz, A . EMBO J. - 14 (6) : 1145-1155 (PMID: 7720705)
1 Dec | 1994 Characterization of the promoter region and flanking sequences of the neuron-specific gene RC3 (neurogranin). Iñiguez, MA, Morte, B , Rodriguez-Peña, A , Muñoz, A , Gerendasy, D, Sutcliffe, JG, Bernal, J . Brain Res. Mol. Brain Res. - 27 (2) : 205-214 (PMID: 7898304)
1 Dec | 1994 Expression of neurotrophins and the trk family of neurotrophin receptors in normal and hypothyroid rat brain. Alvarez-Dolado, M , Iglesias, T , Rodríguez-Peña, A , Bernal, J , Muñoz, A . Brain Res. Mol. Brain Res. - 27 (2) : 249-257 (PMID: 7898308)
11 Oct | 1994 Isolation of genomic DNA fragments corresponding to genes modulated in vivo by a transcription factor. Caubín, J, Iglesias, T , Bernal, J , Muñoz, A , Márquez, G, Barbero, JL, Zaballos, A. Nucleic Acids Res. - 22 (20) : 4132-4138 (PMID: 7937138)
1 Jul | 1994 c-erbA and v-erbA modulate growth and gene expression of a mouse glial precursor cell line. Iglesias, T , Llanos, S, López-Barahona, M, Pérez-Aranda, A, Rodríguez-Peña, A , Bernal, J , Höhne, A, Seliger, B, Muñoz, A . Cell Growth Differ. - 5 (7) : 697-704 (PMID: 7947384)
5 Dec | 1993 Retinoic acid posttranscriptionally up-regulates proteolipid protein gene expression in C6 glioma cells. López-Barahona, M, Miñano, M , Mira, E, Iglesias, T , Stunnenberg, HG, Rodríguez-Peña, A , Bernal, J , Muñoz, A . J. Biol. Chem. - 268 (34) : 25617-25623 (PMID: 7503983)
15 Oct | 1993 Brain-specific prostaglandin D2 synthetase mRNA is dependent on thyroid hormone during rat brain development. García-Fernández, LF , Iñiguez, MA, Rodríguez-Peña, A , Muñoz, A , Bernal, J . Biochem. Biophys. Res. Commun. - 196 (1) : 396-401 (PMID: 8216319)
1 Aug | 1993 Thyroid hormone regulation of RC3, a brain-specific gene encoding a protein kinase-C substrate. Iñiguez, MA, Rodriguez-Peña, A , Ibarrola, N , Aguilera, M, Muñoz, A , Bernal, J . Endocrinology - 133 (2) : 467-473 (PMID: 8344193) (doi:10.1210/endo.133.2.8344193)
1 Apr | 1993 Thyroid hormone receptor/c-erbA: control of commitment and differentiation in the neuronal/chromaffin progenitor line PC12. Muñoz, A , Wrighton, C, Seliger, B, Bernal, J , Beug, H. J. Cell Biol. - 121 (2) : 423-438 (PMID: 8385673)
1 Mar | 1993 Neonatal hypothyroidism affects the timely expression of myelin-associated glycoprotein in the rat brain. Rodriguez-Peña, A , Ibarrola, N , Iñiguez, MA, Muñoz, A , Bernal, J . J. Clin. Invest. - 91 (3) : 812-818 (PMID: 7680668) (doi:10.1172/JCI116301)
6 Oct | 1992 Influence of thyroid hormone on brain gene expression. Bernal, J , Rodriguez-Pena, A , Iniguez, MA, Ibarrola, N , Munoz, A . Acta Med. Austriaca - 19 Suppl 1 : 32-35 (PMID: 1519449)
1 Feb | 1991 Effects of neonatal hypothyroidism on rat brain gene expression. Muñoz, A , Rodriguez-Peña, A , Perez-Castillo, A , Ferreiro, B, Sutcliffe, JG, Bernal, J . Mol. Endocrinol. - 5 (2) : 273-280 (PMID: 1710032) (doi:10.1210/mend-5-2-273)
31 Dec | 1990 Ectopic expression of the erythrocyte band 3 anion exchange protein, using a new avian retrovirus vector. Fuerstenberg, S, Beug, H, Introna, M, Khazaie, K, Muñoz, A , Ness, S, Nordström, K, Sap, J, Stanley, I, Zenke, M. J. Virol. - 64 (12) : 5891-5902 (PMID: 2173771)
15 Jun | 1990 v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA. Zenke, M, Muñoz, A , Sap, J, Vennström, B , Beug, H. Cell - 61 (6) : 1035-1049 (PMID: 1972036)
1 Mar | 1990 Requirement for the C-terminal domain of the v-erbA oncogene protein for biological function and transcriptional repression. Forrest, D, Muñoz, A , Raynoschek, C, Vennström, B , Beug, H. Oncogene - 5 (3) : 309-316 (PMID: 1969136)
1 Feb | 1990 The chicken c-erbA alpha-product induces expression of thyroid hormone-responsive genes in 3,5,3'-triiodothyronine receptor-deficient rat hepatoma cells. Muñoz, A , Höppner, W, Sap, J, Brady, G, Nordström, K, Seitz, HJ, Vennström, B . Mol. Endocrinol. - 4 (2) : 312-320 (PMID: 2158623) (doi:10.1210/mend-4-2-312)
20 Jul | 1989 Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product. Sap, J, Muñoz, A , Schmitt, J, Stunnenberg, H, Vennström, B . Nature - 340 (6230) : 242-244 (PMID: 2569164) (doi:10.1038/340242a0)
1 Jan | 1988 Characterization of the hormone-binding domain of the chicken c-erbA/thyroid hormone receptor protein. Muñoz, A , Zenke, M, Gehring, U, Sap, J, Beug, H, Vennström, B . EMBO J. - 7 (1) : 155-159 (PMID: 3359993)
17 Feb | 1987 The c-erb-A protein is a high-affinity receptor for thyroid hormone. Sap, J, Muñoz, A , Damm, K, Goldberg, Y, Ghysdael, J, Leutz, A, Beug, H, Vennström, B . Nature - 324 (6098) : 635-640 (PMID: 2879242) (doi:10.1038/324635a0)
1 Jul | 1986 Potentiation by levamisole, methisoprinol, and adenine or adenosine of the inhibitory activity of human interferon against encephalomyocarditis virus. Muñoz, A , García, RA, Pérez-Aranda, A. Antimicrob. Agents Chemother. - 30 (1) : 192-195 (PMID: 2428301)
17 Dec | 1985 Cloning and expression of human interleukin 2 in Streptomyces lividans using the Escherichia coli consensus promoter. Muñoz, A , Perez-Aranda, A, Barbero, JL. Biochem. Biophys. Res. Commun. - 133 (2) : 511-519 (PMID: 3910038)
30 Oct | 1985 Modification of membrane permeability during Semliki Forest virus infection. Muñoz, A , Castrillo, JL, Carrasco, L. Virology - 146 (2) : 203-212 (PMID: 4049733)
1 Oct | 1985 The regulation of translation in reovirus-infected cells. Muñoz, A , Alonso, MA, Carrasco, L. J. Gen. Virol. - 66 ( Pt 10) : 2161-2170 (PMID: 2995553)
1 Aug | 1984 Synthesis of heat-shock proteins in HeLa cells: inhibition by virus infection. Muñoz, A , Alonso, MA, Carrasco, L. Virology - 137 (1) : 150-159 (PMID: 6089412)
1 Jun | 1984 Formation of non-infective herpesvirus particles in cultured cells treated with human interferon. Muñoz, A , Carrasco, L. J. Gen. Virol. - 65 ( Pt 6) : 1069-1078 (PMID: 6327892)
1 Feb | 1984 Action of human lymphoblastoid interferon on HeLa cells infected with RNA-containing animal viruses. Muñoz, A , Carrasco, L. J. Gen. Virol. - 65 ( Pt 2) : 377-390 (PMID: 6319580)
15 Dec | 1983 Effect of interferon treatment on blockade of protein synthesis induced by poliovirus infection. Muñoz, A , Carrasco, L. Eur. J. Biochem. - 137 (3) : 623-629 (PMID: 6198175)
26 Aug | 1983 Enhancement of susceptibility of HSV-1-infected cells to natural killer lysis by interferon. Muñoz, A , Carrasco, L, Fresno, M. J. Immunol. - 131 (2) : 783-787 (PMID: 6190939)
22 Aug | 1983 Cellular RNA is not degraded in interferon-treated HeLa cells after poliovirus infection. Muñoz, A , Harvey, R, Carrasco, L. FEBS Lett. - 160 (1-2) : 87-92 (PMID: 6309570)
1 Oct | 1981 Reversal by hypotonic medium of the antiviral state induced by lymphoblastoid interferon in human HeLa cells. Muñoz, A , Carrasco, L. Intervirology - 16 (2) : 106-113 (PMID: 6173348)
1 Sep | 1981 Protein synthesis and membrane integrity in interferon-treated HeLa cells infected with encephalomyocarditis virus. Muñoz, A , Carrasco, L. J. Gen. Virol. - 56 (Pt 1) : 153-162 (PMID: 6170728)