30 Jan | 2025 Liver X Receptors and Inflammatory-Induced C/EBPβ Selectively Cooperate to Control CD38 Transcription. Glaría, E, Martínez, PR, Font-Díaz, J, De la Rosa, JV, Castrillo, A , Crawshaw, DJ, Vidal Taboada, JM, Saura, J, Matalonga, J, Nunes Chini, E, Caelles, C, Valledor, AF. J Innate Immun - 17 (1) : 56-77 (PMID: 39701049) (doi:10.1159/000543274)
6 Nov | 2024 Immunometabolic Effect of Nitric Oxide on Human Macrophages Challenged With the SARS-CoV2-Induced Cytokine Storm. A Fluxomic Approach. Sánchez-García, S , Povo-Retana, A , Marin, S, Madurga, S, Fariñas, M, Aleixandre, N, Castrillo, A , de la Rosa, JV, Alvarez-Lucena, C , Landauro-Vera, R , Prieto, P , Cascante, M, Boscá, L . Adv Healthc Mater (PMID: 39502019) (doi:10.1002/adhm.202401688)
26 Oct | 2024 Potential Beneficial Role of Nitric Oxide in SARS-CoV-2 Infection: Beyond Spike-Binding Inhibition. Sánchez-García, S , Castrillo, A , Boscá, L , Prieto, P . Antioxidants (Basel) - 13 (11) (PMID: 39594443) (doi:10.3390/antiox13111301)
15 Aug | 2024 Modulation of the K/BxN arthritis mouse model and the effector functions of human fibroblast-like synoviocytes by liver X receptors. Domínguez-Luis, MJ, Castro-Hernández, J, Santos-Concepción, S, Díaz-Martín, A, Arce-Franco, M, Pérez-González, N, Díaz, M, Castrillo, A , Salido, E, Machado, JD, Gumá, M, Corr, M, Díaz-González, F. Eur J Immunol (PMID: 39148175) (doi:10.1002/eji.202451136)
6 Jul | 2024 Endogenous LXR signaling controls pulmonary surfactant homeostasis and prevents lung inflammation. Hernández-Hernández, I, De La Rosa, JV, Martín-Rodríguez, P, Díaz-Sarmiento, M, Recio, C, Guerra, B, Fernández-Pérez, L, León, TE, Torres, R, Font-Díaz, J, Roig, A, de Mora, F, Boscá, L , Díaz, M, Valledor, AF, Castrillo, A , Tabraue, C. Cell Mol Life Sci - 81 (1) : 287 (PMID: 38970705) (doi:10.1007/s00018-024-05310-3)
28 Mar | 2024 Reprogramming of the LXRα Transcriptome Sustains Macrophage Secondary Inflammatory Responses. Vladimir de la Rosa, J, Tabraue, C, Huang, Z, Orizaola, MC , Martin-Rodríguez, P, Steffensen, KR, Zapata, JM , Boscá, L , Tontonoz, P, Alemany, S , Treuter, E, Castrillo, A . Adv Sci (Weinh) (PMID: 38549193) (doi:10.1002/advs.202307201)
8 Dec | 2023 Transcriptomic and lipid profiling analysis reveals a functional interplay between testosterone and growth hormone in hypothyroid liver. Fernández-Pérez, L, Guerra, B, Recio, C, Cabrera-Galván, JJ, García, I, De La Rosa, JV, Castrillo, A , Iglesias-Gato, D, Díaz, M. Front Endocrinol (Lausanne) - 14 : 1266150 (PMID: 38144555) (doi:10.3389/fendo.2023.1266150)
22 Aug | 2023 Immunometabolic actions of trabectedin and lurbinectedin on human macrophages: relevance for their anti-tumor activity. Povo-Retana, A , Fariñas, M, Landauro-Vera, R , Mojena, M , Alvarez-Lucena, C , Fernández-Moreno, MA , Castrillo, A , de la Rosa Medina, JV, Sánchez-García, S , Foguet, C, Mas, F, Marin, S, Cascante, M, Boscá, L . Front Immunol - 14 : 1211068 (PMID: 37675104) (doi:10.3389/fimmu.2023.1211068)
17 Mar | 2023 Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB. de la Aleja, AG, Herrero, C, Torres-Torresano, M, Schiaffino, MT, Del Castillo, A, Alonso, B, Vega, MA, Puig-Kröger, A, Castrillo, A , Corbí, ÁL. Cell Mol Life Sci - 80 (4) : 96 (PMID: 36930354) (doi:10.1007/s00018-023-04745-4)
4 Aug | 2022 Unraveling the interplay between iron homeostasis, ferroptosis and extramedullary hematopoiesis. Fernández-García, V , González-Ramos, S , Martín-Sanz, P , Castrillo, A , Boscá, L . Pharmacol Res - 183 : 106386 (PMID: 35933006) (doi:10.1016/j.phrs.2022.106386)
22 Jul | 2022 Regulation of metabolic and transcriptional responses by the thyroid hormone in cellular models of murine macrophages. López-Mateo, I , Rodríguez-Muñoz, D , de La Rosa, JV, Castrillo, A , Alemany, S , Aranda, A . Front Immunol - 13 : 923727 (PMID: 35935955) (doi:10.3389/fimmu.2022.923727)
5 Jul | 2022 High-fat diet activates splenic NOD1 and enhances neutrophil recruitment and neutrophil extracellular traps release in the spleen of ApoE-deficient mice. Fernández-García, V , González-Ramos, S , Avendaño-Ortiz, J, Martín-Sanz, P , Gómez-Coronado, D, Delgado, C , Castrillo, A , Boscá, L . Cell Mol Life Sci - 79 (8) : 396 (PMID: 35789437) (doi:10.1007/s00018-022-04415-x)
3 Mar | 2022 NOD1 splenic activation confers ferroptosis protection and reduces macrophage recruitment under pro-atherogenic conditions. Fernández-García, V , González-Ramos, S , Avendaño-Ortiz, J, Martín-Sanz, P , Delgado, C , Castrillo, A , Boscá, L . Biomed Pharmacother - 148 : 112769 (PMID: 35247718) (doi:10.1016/j.biopha.2022.112769)
24 Feb | 2022 Activation of LXR Nuclear Receptors Impairs the Anti-Inflammatory Gene and Functional Profile of M-CSF-Dependent Human Monocyte-Derived Macrophages. González de la Aleja, A, Herrero, C, Torres-Torresano, M, de la Rosa, JV, Alonso, B, Capa-Sardón, E, Muller, IB, Jansen, G, Puig-Kröger, A, Vega, MA, Castrillo, A , Corbí, ÁL. Front Immunol - 13 : 835478 (PMID: 35280993) (doi:10.3389/fimmu.2022.835478)
27 May | 2021 Crosstalk Between LXR and Caveolin-1 Signaling Supports Cholesterol Efflux and Anti-Inflammatory Pathways in Macrophages. Ramírez, CM, Torrecilla-Parra, M, Pardo-Marqués, V, de-Frutos, MF, Pérez-García, A, Tabraue, C, de la Rosa, JV, Martín-Rodriguez, P, Díaz-Sarmiento, M, Nuñez, U, Orizaola, MC , Través, PG , Camps, M, Boscá, L , Castrillo, A . Front Endocrinol (Lausanne) - 12 : 635923 (PMID: 34122329) (doi:10.3389/fendo.2021.635923)
23 Dec | 2020 Pharmacological activation of LXR alters the expression profile of tumor-associated macrophages and the abundance of regulatory T cells in the tumor microenvironment. Carbó, JM, León, TE, Font-Díaz, J, De la Rosa, JV, Castrillo, A , Picard, FR, Staudenraus, D, Huber, M, Cedó, L, Escolà-Gil, JC, Campos, L, Bakiri, L, Wagner, EF, Caelles, C, Stratmann, T, Van Ginderachter, JA, Valledor, AF. Cancer Res (PMID: 33361391) (doi:10.1158/0008-5472.CAN-19-3360)
9 Dec | 2020 Nuclear receptors: lipid and hormone sensors with essential roles in the control of cancer development. Font-Díaz, J, Jiménez-Panizo, A, Caelles, C, Vivanco, MD, Pérez, P, Aranda, A , Estébanez-Perpiñá, E, Castrillo, A , Ricote, M, Valledor, AF. Semin Cancer Biol (PMID: 33309851) (doi:10.1016/j.semcancer.2020.12.007)
28 Oct | 2020 Stress erythropoiesis in atherogenic mice. Sánchez, Á , Orizaola, MC , Rodríguez-Muñoz, D , Aranda, A , Castrillo, A , Alemany, S . Sci Rep - 10 (1) : 18469 (PMID: 33116141) (doi:10.1038/s41598-020-74665-x)
26 Oct | 2020 Contribution of Extramedullary Hematopoiesis to Atherosclerosis. The Spleen as a Neglected Hub of Inflammatory Cells. Fernández-García, V , González-Ramos, S , Martín-Sanz, P , Castrillo, A , Boscá, L . Front Immunol - 11 : 586527 (PMID: 33193412) (doi:10.3389/fimmu.2020.586527)
15 Sep | 2020 A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart. Nicolás-Ávila, JA, Lechuga-Vieco, AV, Esteban-Martínez, L, Sánchez-Díaz, M, Díaz-García, E, Santiago, DJ, Rubio-Ponce, A, Li, JL, Balachander, A, Quintana, JA, Martínez-de-Mena, R , Castejón-Vega, B, Pun-García, A, Través, PG , Bonzón-Kulichenko, E, García-Marqués, F, Cussó, L, A-González, N, González-Guerra, A, Roche-Molina, M, Martin-Salamanca, S, Crainiciuc, G, Guzmán, G, Larrazabal, J, Herrero-Galán, E, Alegre-Cebollada, J, Lemke, G, Rothlin, CV, Jimenez-Borreguero, LJ, Reyes, G, Castrillo, A , Desco, M, Muñoz-Cánoves, P, Ibáñez, B, Torres, M, Ng, LG, Priori, SG, Bueno, H, Vázquez, J, Cordero, MD, Bernal, JA, Enríquez, JA, Hidalgo, A. Cell (PMID: 32937105) (doi:10.1016/j.cell.2020.08.031)
23 Jul | 2020 NOD1 deficiency promotes an imbalance of thyroid hormones and microbiota homeostasis in mice fed high fat diet. González-Ramos, S , Paz-García, M , Fernández-García, V , Portune, KJ, Acosta-Medina, EF, Sanz, Y, Castrillo, A , Martín-Sanz, P , Obregon, MJ , Boscá, L . Sci Rep - 10 (1) : 12317 (PMID: 32704052) (doi:10.1038/s41598-020-69295-2)
15 Jul | 2019 Analysis of LXR Nuclear Receptor Cistrome Through ChIP-Seq Data Bioinformatics. de la Rosa, JV, Ramón-Vázquez, A , Tabraue, C, Castrillo, A . Methods Mol. Biol. - 1951 : 99-9109 (PMID: 30825147) (doi:10.1007/978-1-4939-9130-3_8)
15 Jul | 2019 Bone Marrow-Derived Macrophage Immortalization of LXR Nuclear Receptor-Deficient Cells. Ramón-Vázquez, A , de la Rosa, JV, Tabraue, C, Castrillo, A . Methods Mol. Biol. - 1951 : 75-85 (PMID: 30825145) (doi:10.1007/978-1-4939-9130-3_6)
15 Jul | 2019 LXR Signaling Regulates Macrophage Survival and Inflammation in Response to Ionizing Radiation. Tabraue, C, Lara, PC, De Mirecki-Garrido, M, De La Rosa, JV, López-Blanco, F, Fernández-Pérez, L, Boscá, L , Castrillo, A . Int. J. Radiat. Oncol. Biol. Phys. - 104 (4) : 913-923 (PMID: 30922944) (doi:10.1016/j.ijrobp.2019.03.028)
1 May | 2019 SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity. Keiran, N, Ceperuelo-Mallafré, V, Calvo, E, Hernández-Alvarez, MI, Ejarque, M, Núñez-Roa, C, Horrillo, D, Maymó-Masip, E, Rodríguez, MM, Fradera, R, de la Rosa, JV, Jorba, R, Megia, A, Zorzano, A, Medina-Gómez, G , Serena, C, Castrillo, A , Vendrell, J, Fernández-Veledo, S. Nat. Immunol. - 20 (5) : 581-592 (PMID: 30962591) (doi:10.1038/s41590-019-0372-7)
2 Jan | 2019 Common and Differential Transcriptional Actions of Nuclear Receptors LXRα and LXRβ in macrophages. Ramón-Vázquez, A , de la Rosa, JV, Tabraue, C, Lopez, F, Díaz-Chico, BN, Bosca, L , Tontonoz, P, Alemany, S , Castrillo, A . Mol. Cell. Biol. (PMID: 30602495) (doi:10.1128/MCB.00376-18)
1 Jan | 2019 DEL-1 promotes macrophage efferocytosis and clearance of inflammation. Kourtzelis, I, Li, X, Mitroulis, I, Grosser, D, Kajikawa, T, Wang, B, Grzybek, M, von Renesse, J, Czogalla, A, Troullinaki, M, Ferreira, A, Doreth, C, Ruppova, K, Chen, LS, Hosur, K, Lim, JH, Chung, KJ, Grossklaus, S, Tausche, AK, Joosten, LAB, Moutsopoulos, NM, Wielockx, B, Castrillo, A , Korostoff, JM, Coskun, Ü, Hajishengallis, G, Chavakis, T. Nat. Immunol. - 20 (1) : 40-49 (PMID: 30455459) (doi:10.1038/s41590-018-0249-1)
1 Nov | 2018 Phenalenone-photodynamic therapy induces apoptosis on human tumor cells mediated by caspase-8 and p38-MAPK activation. Salmerón, ML, Quintana-Aguiar, J, De La Rosa, JV, López-Blanco, F, Castrillo, A , Gallardo, G, Tabraue, C. Mol. Carcinog. - 57 (11) : 1525-1539 (PMID: 30035337) (doi:10.1002/mc.22875)
1 Aug | 2018 Origin and specialization of splenic macrophages. A-Gonzalez, N, Castrillo, A . Cell. Immunol. - 330 : 151-158 (PMID: 29779612) (doi:10.1016/j.cellimm.2018.05.005)
10 Jul | 2018 Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation. Gage, MC, Bécares, N, Louie, R, Waddington, KE, Zhang, Y, Tittanegro, TH, Rodríguez-Lorenzo, S, Jathanna, A, Pourcet, B, Pello, OM, De la Rosa, JV, Castrillo, A , Pineda-Torra, I. Proc. Natl. Acad. Sci. U.S.A. - 115 (28) : E6556-E6565 (PMID: 29950315) (doi:10.1073/pnas.1721245115)
15 May | 2018 Liver X Receptor Nuclear Receptors Are Transcriptional Regulators of Dendritic Cell Chemotaxis. Beceiro, S, Pap, A, Czimmerer, Z, Sallam, T, Guillén, JA , Gallardo, G, Hong, C, A-Gonzalez, N, Tabraue, C, Diaz, M , Lopez, F, Matalonga, J, Valledor, AF, Dominguez, P, Ardavin, C, Delgado-Martin, C, Partida-Sanchez, S, Rodriguez-Fernandez, JL, Nagy, L, Tontonoz, P, Castrillo, A . Mol. Cell. Biol. - 38 (10) (PMID: 29507185) (doi:10.1128/MCB.00534-17)
1 Mar | 2018 Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA. Sallam, T, Jones, M, Thomas, BJ, Wu, X, Gilliland, T, Qian, K, Eskin, A, Casero, D, Zhang, Z, Sandhu, J, Salisbury, D, Rajbhandari, P, Civelek, M, Hong, C, Ito, A, Liu, X, Daniel, B, Lusis, AJ, Whitelegge, J, Nagy, L, Castrillo, A , Smale, S, Tontonoz, P. Nat. Med. - 24 (3) : 304-312 (PMID: 29431742) (doi:10.1038/nm.4479)
29 Jan | 2018 The Activin A-Peroxisome Proliferator-Activated Receptor Gamma Axis Contributes to the Transcriptome of GM-CSF-Conditioned Human Macrophages. Nieto, C, Bragado, R, Municio, C, Sierra-Filardi, E, Alonso, B, Escribese, MM, Domínguez-Andrés, J, Ardavín, C, Castrillo, A , Vega, MA, Puig-Kröger, A, Corbí, AL. Front Immunol - 9 : 31 (PMID: 29434585) (doi:10.3389/fimmu.2018.00031)
25 Oct | 2017 Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP. Zhang, L, Rajbhandari, P, Priest, C, Sandhu, J, Wu, X, Temel, R, Castrillo, A , de Aguiar Vallim, TQ, Sallam, T, Tontonoz, P. Elife - 6 (PMID: 29068315) (doi:10.7554/eLife.28766)
17 Oct | 2017 Outbreak and Eradication of Tropical Rat Mite (Acari: Macronyssidae) in a European Animal Facility. Brito-Casillas, Y, Díaz-Sarmiento, M, García-Arencibia, M, Carranza, C, Castrillo, A , Fernández-Pérez, L, Zumbado-Peña, M, González, JF, Wägner, AM, Florin, D. J. Med. Entomol. (PMID: 29045705) (doi:10.1093/jme/tjx184)
1 May | 2017 Phagocytosis imprints heterogeneity in tissue-resident macrophages. A-Gonzalez, N, Quintana, JA, García-Silva, S , Mazariegos, M, González de la Aleja, A, Nicolás-Ávila, JA, Walter, W, Adrover, JM, Crainiciuc, G, Kuchroo, VK, Rothlin, CV, Peinado, H , Castrillo, A , Ricote, M, Hidalgo, A. J. Exp. Med. - 214 (5) : 1281-1296 (PMID: 28432199) (doi:10.1084/jem.20161375)
1 Mar | 2017 MAFB Determines Human Macrophage Anti-Inflammatory Polarization: Relevance for the Pathogenic Mechanisms Operating in Multicentric Carpotarsal Osteolysis. Cuevas, VD, Anta, L, Samaniego, R, Orta-Zavalza, E, Vladimir de la Rosa, J, Baujat, G, Domínguez-Soto, Á, Sánchez-Mateos, P, Escribese, MM, Castrillo, A , Cormier-Daire, V, Vega, MA, Corbí, ÁL. J. Immunol. - 198 (5) : 2070-2081 (PMID: 28093525) (doi:10.4049/jimmunol.1601667)
31 Jan | 2017 The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism. Matalonga, J, Glaria, E, Bresque, M, Escande, C, Carbó, JM, Kiefer, K, Vicente, R, León, TE, Beceiro, S, Pascual-García, M, Serret, J, Sanjurjo, L, Morón-Ros, S, Riera, A, Paytubi, S, Juarez, A, Sotillo, F, Lindbom, L, Caelles, C, Sarrias, MR, Sancho, J, Castrillo, A , Chini, EN, Valledor, AF. Cell Rep - 18 (5) : 1241-1255 (PMID: 28147278) (doi:10.1016/j.celrep.2017.01.007)
20 Dec | 2016 Cholesterol Accumulation in CD11c(+) Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease. Ito, A, Hong, C, Oka, K, Salazar, JV, Diehl, C, Witztum, JL, Diaz, M , Castrillo, A , Bensinger, SJ, Chan, L, Tontonoz, P. Immunity - 45 (6) : 1311-1326 (PMID: 28002731) (doi:10.1016/j.immuni.2016.11.008)
6 Oct | 2016 Fungal pattern receptors down-regulate the inflammatory response by a cross-inhibitory mechanism independent of IL-10 production. Rodríguez, M, Márquez, S, de la Rosa, JV, Alonso, S, Castrillo, A , Sánchez Crespo, M, Fernández, N. Immunology (PMID: 27709605) (doi:10.1111/imm.12678)
6 May | 2016 The nuclear receptor LXR modulates interleukin-18 levels in macrophages through multiple mechanisms. Pourcet, B, Gage, MC, León, TE, Waddington, KE, Pello, OM, Steffensen, KR, Castrillo, A , Valledor, AF, Pineda-Torra, I. Sci Rep - 6 : 25481 (PMID: 27149934) (doi:10.1038/srep25481)
15 Nov | 2014 Intravenous immunoglobulin promotes antitumor responses by modulating macrophage polarization. Domínguez-Soto, A, de las Casas-Engel, M, Bragado, R, Medina-Echeverz, J, Aragoneses-Fenoll, L, Martín-Gayo, E, van Rooijen, N, Berraondo, P, Toribio, ML, Moro, MA, Cuartero, I, Castrillo, A , Sancho, D, Sánchez-Torres, C, Bruhns, P, Sánchez-Ramón, S, Corbí, AL. J. Immunol. - 193 (10) : 5181-5189 (PMID: 25326025) (doi:10.4049/jimmunol.1303375)
14 Aug | 2014 Anti-inflammatory actions of acanthoic acid-related diterpenes involve activation of the PI3K p110γ/δ subunits and inhibition of NF-κB. Través, PG , Pimentel-Santillana, M , Rico, D, Rodriguez, N, Miethke, T, Castrillo, A , Theodorakis, EA, Martín-Sanz, P , Palladino, MA, Boscá, L . Chem. Biol. - 21 (8) : 955-966 (PMID: 25065531) (doi:10.1016/j.chembiol.2014.06.005)
1 Aug | 2013 The nuclear receptor LXRα controls the functional specialization of splenic macrophages. A-Gonzalez, N, Guillen, JA, Gallardo, G, Diaz, M , de la Rosa, JV, Hernandez, IH, Casanova-Acebes, M, Lopez, F, Tabraue, C, Beceiro, S, Hong, C, Lara, PC, Andujar, M, Arai, S, Miyazaki, T, Li, S, Corbi, AL, Tontonoz, P, Hidalgo, A, Castrillo, A . Nat. Immunol. - 14 (8) : 831-839 (PMID: 23770640) (doi:10.1038/ni.2622)
27 Nov | 2012 Oxysterol-induced soluble endoglin release and its involvement in hypertension. Valbuena-Diez, AC, Blanco, FJ, Oujo, B, Langa, C, Gonzalez-Nuñez, M, Llano, E, Pendas, AM, Díaz, M, Castrillo, A , Lopez-Novoa, JM, Bernabeu, C. Circulation - 126 (22) : 2612-2624 (PMID: 23110859) (doi:10.1161/CIRCULATIONAHA.112.101261)
4 Jan | 2012 Coordinate regulation of neutrophil homeostasis by liver X receptors in mice. Hong, C, Kidani, Y, A-Gonzalez, N, Phung, T, Ito, A, Rong, X, Ericson, K, Mikkola, H, Beaven, SW, Miller, LS, Shao, WH, Cohen, PL, Castrillo, A , Tontonoz, P, Bensinger, SJ. J. Clin. Invest. - 122 (1) : 337-347 (PMID: 22156197) (doi:10.1172/JCI58393)
5 Aug | 2011 Liver X receptors as regulators of macrophage inflammatory and metabolic pathways. A-González, N, Castrillo, A . Biochim. Biophys. Acta - 1812 (8) : 982-994 (PMID: 21193033) (doi:10.1016/j.bbadis.2010.12.015)
15 Jun | 2011 Involvement of adenosine A2A receptors in engulfment-dependent apoptotic cell suppression of inflammation. Köröskényi, K, Duró, E, Pallai, A, Sarang, Z, Kloor, D, Ucker, DS, Beceiro, S, Castrillo, A , Chawla, A, Ledent, CA, Fésüs, L, Szondy, Z. J. Immunol. - 186 (12) : 7144-7155 (PMID: 21593381) (doi:10.4049/jimmunol.1002284)
3 Jun | 2011 Cooperation of adenosine with macrophage Toll-4 receptor agonists leads to increased glycolytic flux through the enhanced expression of PFKFB3 gene. Ruiz-García, A, Monsalve, E, Novellasdemunt, L, Navarro-Sabaté, A, Manzano, A, Rivero, S, Castrillo, A , Casado, M, Laborda, J, Bartrons, R, Díaz-Guerra, MJ. J. Biol. Chem. - 286 (22) : 19247-19258 (PMID: 21464136) (doi:10.1074/jbc.M110.190298)
21 Aug | 2009 Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. A-Gonzalez, N, Bensinger, SJ, Hong, C, Beceiro, S, Bradley, MN, Zelcer, N, Deniz, J, Ramirez, C, Díaz, M, Gallardo, G, de Galarreta, CR, Salazar, J, Lopez, F, Edwards, P, Parks, J, Andujar, M, Tontonoz, P, Castrillo, A . Immunity - 31 (2) : 245-258 (PMID: 19646905) (doi:10.1016/j.immuni.2009.06.018)
30 Sep | 2008 Activation of liver X receptors promotes neuroprotection and reduces brain inflammation in experimental stroke. Morales, JR, Ballesteros, I, Deniz, JM, Hurtado, O, Vivancos, J, Nombela, F, Lizasoain, I, Castrillo, A , Moro, MA. Circulation - 118 (14) : 1450-1459 (PMID: 18794391) (doi:10.1161/CIRCULATIONAHA.108.782300)
1 Jun | 2008 Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity. Gallardo-Soler, A, Gómez-Nieto, C, Campo, ML, Marathe, C, Tontonoz, P, Castrillo, A , Corraliza, I. Mol Endocrinol - 22 (6) : 1394-1402 (PMID: 18323470) (doi:10.1210/me.2007-0525)
1 Jun | 2007 Selective activation of liver X receptors by acanthoic acid-related diterpenes. Traves, PG, Hortelano, S, Zeini, M, Chao, TH, Lam, T, Neuteboom, ST, Theodorakis, EA, Palladino, MA, Castrillo, A , Bosca, L . Mol. Pharmacol. - 71 (6) : 1545-1553 (PMID: 17329499) (doi:10.1124/mol.106.031906)
6 Aug | 2004 The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras. Oliva, JL, Zarich, N, Martínez, N, Jorge, R, Castrillo, A , Azañedo, M, García-Vargas, S, Gutiérrez-Eisman, S, Juarranz, A, Boscá, L , Gutkind, JS, Rojas, JM. J. Biol. Chem. - 279 (32) : 33480-33491 (PMID: 15181015) (doi:10.1074/jbc.M404058200)
15 Apr | 2003 The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras. Oliva, JL, Pérez-Sala, D, Castrillo, A , Martínez, N, Cañada, FJ, Boscá, L , Rojas, JM. Proc. Natl. Acad. Sci. U.S.A. - 100 (8) : 4772-4777 (PMID: 12684535) (doi:10.1073/pnas.0735842100)
1 Mar | 2003 Selective inhibitors of cyclooxygenase-2 delay the activation of nuclear factor kappa B and attenuate the expression of inflammatory genes in murine macrophages treated with lipopolysaccharide. Callejas, NA, Fernández-Martínez, A, Castrillo, A , Boscá, L , Martín-Sanz, P . Mol. Pharmacol. - 63 (3) : 671-677 (PMID: 12606776)
1 Feb | 2003 Potentiation of protein kinase C zeta activity by 15-deoxy-delta(12,14)-prostaglandin J(2) induces an imbalance between mitogen-activated protein kinases and NF-kappa B that promotes apoptosis in macrophages. Castrillo, A , Través, PG , Martín-Sanz, P , Parkinson, S, Parker, PJ, Boscá, L . Mol. Cell. Biol. - 23 (4) : 1196-1208 (PMID: 12556480)
30 Jan | 2003 H-Ras-specific activation of NF-kappaB protects NIH 3T3 cells against stimulus-dependent apoptosis. Millán, O , Ballester, A, Castrillo, A , Oliva, JL, Través, PG , Rojas, JM, Boscá, L . Oncogene - 22 (4) : 477-483 (PMID: 12555061) (doi:10.1038/sj.onc.1206179)
17 Jun | 2002 Interleukin-4 and interleukin-10 modulate nuclear factor kappaB activity and nitric oxide synthase-2 expression in Theiler's virus-infected brain astrocytes. Molina-Holgado, E, Arévalo-Martín, A, Castrillo, A , Boscá, L , Vela, JM, Guaza, C. J. Neurochem. - 81 (6) : 1242-1252 (PMID: 12068072)
1 Jun | 2002 Induction of apoptosis by nitric oxide in macrophages is independent of apoptotic volume decrease. Hortelano, S, Zeini, M, Castrillo, A , Alvarez, AM, Boscá, L . Cell Death Differ. - 9 (6) : 643-650 (PMID: 12032673) (doi:10.1038/sj/cdd/4401017)
20 Feb | 2002 The increase in TNF-alpha levels is implicated in NF-kappaB activation and inducible nitric oxide synthase expression in brain cortex after immobilization stress. Madrigal, JL, Hurtado, O, Moro, MA, Lizasoain, I, Lorenzo, P, Castrillo, A , Boscá, L , Leza, JC. Neuropsychopharmacology - 26 (2) : 155-163 (PMID: 11790511) (doi:10.1016/S0893-133X(01)00292-5)
5 Nov | 2001 Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection. Castrillo, A , Pennington, DJ, Otto, F, Parker, PJ, Owen, MJ, Boscá, L . J. Exp. Med. - 194 (9) : 1231-1242 (PMID: 11696589)
12 Oct | 2001 Intracellular water motion decreases in apoptotic macrophages after caspase activation. Hortelano, S, García-Martín, ML , Cerdán, S , Castrillo, A , Alvarez, AM, Boscá, L . Cell Death Differ. - 8 (10) : 1022-1028 (PMID: 11598800) (doi:10.1038/sj.cdd.4400913)
7 Sep | 2001 Peroxisome proliferator-activated receptor-gamma-independent inhibition of macrophage activation by the non-thiazolidinedione agonist L-796,449. Comparison with the effects of 15-deoxy-delta(12,14)-prostaglandin J(2). Castrillo, A , Mojena, M , Hortelano, S, Boscá, L . J. Biol. Chem. - 276 (36) : 34082-34088 (PMID: 11438523) (doi:10.1074/jbc.M102472200)
11 May | 2001 Inhibition of the nuclear factor kappa B (NF-kappa B) pathway by tetracyclic kaurene diterpenes in macrophages. Specific effects on NF-kappa B-inducing kinase activity and on the coordinate activation of ERK and p38 MAPK. Castrillo, A , de Las Heras, B, Hortelano, S, Rodriguez, B, Villar, A, Bosca, L . J. Biol. Chem. - 276 (19) : 15854-15860 (PMID: 11278990) (doi:10.1074/jbc.M100010200)
22 Mar | 2001 Protection by nitric oxide against liver inflammatory injury in animals carrying a nitric oxide synthase-2 transgene. Mojena, M , Hortelano, S, Castrillo, A , Diaz-Guerra, MJ, Garcia-Barchino, MJ, Saez, GT, Bosca, L . FASEB J. - 15 (3) : 583-585 (PMID: 11259374) (doi:10.1096/fj.00-0509fje)
1 Jan | 2001 Inducible nitric oxide synthase expression in brain cortex after acute restraint stress is regulated by nuclear factor kappaB-mediated mechanisms. Madrigal, JL, Moro, MA, Lizasoain, I, Lorenzo, P, Castrillo, A , Boscá, L , Leza, JC. J. Neurochem. - 76 (2) : 532-538 (PMID: 11208916)
1 Dec | 2000 Contribution of cyclopentenone prostaglandins to the resolution of inflammation through the potentiation of apoptosis in activated macrophages. Hortelano, S, Castrillo, A , Alvarez, AM, Boscá, L . J. Immunol. - 165 (11) : 6525-6531 (PMID: 11086094)
25 May | 2000 Implication of glutamate in the expression of inducible nitric oxide synthase after oxygen and glucose deprivation in rat forebrain slices. Cárdenas, A, Moro, MA, Hurtado, O, Leza, JC, Lorenzo, P, Castrillo, A , Bodelón, OG, Boscá, L , Lizasoain, I. J. Neurochem. - 74 (5) : 2041-2048 (PMID: 10800947)
16 Mar | 2000 Inhibition of IkappaB kinase and IkappaB phosphorylation by 15-deoxy-Delta(12,14)-prostaglandin J(2) in activated murine macrophages. Castrillo, A , Díaz-Guerra, MJ, Hortelano, S, Martín-Sanz, P , Boscá, L . Mol. Cell. Biol. - 20 (5) : 1692-1698 (PMID: 10669746)
1 Feb | 2000 Inhibitory effect of IGF-I on type 2 nitric oxide synthase expression in Ins-1 cells and protection against activation-dependent apoptosis: involvement of phosphatidylinositol 3-kinase. Castrillo, A , Bodelón, OG, Boscá, L . Diabetes - 49 (2) : 209-217 (PMID: 10868937)
1 Oct | 1999 Inhibition of NOS-2 expression in macrophages through the inactivation of NF-kappaB by andalusol. de las Heras, B, Navarro, A, Díaz-Guerra, MJ, Bermejo, P, Castrillo, A , Boscá, L , Villar, A. Br. J. Pharmacol. - 128 (3) : 605-612 (PMID: 10516639) (doi:10.1038/sj.bjp.0702844)
1 Jun | 1999 Negative regulation by protein tyrosine phosphatase of IFN-gamma-dependent expression of inducible nitric oxide synthase. Díaz-Guerra, MJ, Castrillo, A , Martín-Sanz, P , Boscá, L . J. Immunol. - 162 (11) : 6776-6783 (PMID: 10352298)
15 May | 1999 Negative regulation by phosphatidylinositol 3-kinase of inducible nitric oxide synthase expression in macrophages. Díaz-Guerra, MJ, Castrillo, A , Martín-Sanz, P , Boscá, L . J. Immunol. - 162 (10) : 6184-6190 (PMID: 10229863)
1 Mar | 1999 Inhibition of prostaglandin synthesis up-regulates cyclooxygenase-2 induced by lipopolysaccharide and peroxisomal proliferators. Callejas, NA, Castrillo, A , Boscá, L , Martín-Sanz, P . J. Pharmacol. Exp. Ther. - 288 (3) : 1235-1241 (PMID: 10027864)