14 Mar | 2023 Novel Loss of Function KCNA5 Variants in Pulmonary Arterial Hypertension. Vera-Zambrano, A , Lago-Docampo, M, Gallego, N, Franco-Gonzalez, JF, Morales-Cano, D, Cruz-Utrilla, A, Villegas-Esguevillas, M, Fernández-Malavé, E, Escribano-Subías, P, Tenorio-Castaño, JA, Perez-Vizcaino, F, Valverde, D, González, T , Cogolludo, A, , . Am J Respir Cell Mol Biol (PMID: 36917789) (doi:10.1165/rcmb.2022-0245OC)
3 Feb | 2023 Sigma-1 receptor modulation fine-tunes KV1.5 channels and impacts pulmonary vascular function. Vera-Zambrano, A , Baena-Nuevo, M , Rinné, S, Villegas-Esguevillas, M, Barreira, B, Telli, G, de Benito-Bueno, A , Blázquez, JA, Climent, B, Pérez-Vizcaino, F, Valenzuela, C , Decher, N, Gonzalez, T , Cogolludo, A. Pharmacol Res (PMID: 36740150) (doi:10.1016/j.phrs.2023.106684)
6 Sep | 2022 A novel loss-of-function mutation of the voltage-gated potassium channel Kv10.2 involved in epilepsy and autism. Galán-Vidal, J, Socuéllamos, PG , Baena-Nuevo, M , Contreras, L, González, T , Pérez-Poyato, MS, Valenzuela, C , González-Lamuño, D, Gandarillas, A. Orphanet J Rare Dis - 17 (1) : 345 (PMID: 36068614) (doi:10.1186/s13023-022-02499-z)
4 Apr | 2021 Identification of a critical binding site for local anesthetics in the side pockets of Kv1 channels. Kiper, AK, Bedoya, M, Stalke, S, Marzian, S , Ramírez, D, de la Cruz, A , Peraza, DA , Vera-Zambrano, A , Márquez Montesinos, JCE, Arévalo Ramos, BA, Rinné, S, Gonzalez, T , Valenzuela, C , Gonzalez, W, Decher, N. Br J Pharmacol (PMID: 33817777) (doi:10.1111/bph.15480)
29 Jan | 2021 KV1.5-KVβ1.3 Recycling Is PKC-Dependent. Macias, A , de la Cruz, A , Peraza, DA , Benito-Bueno, A , Gonzalez, T , Valenzuela, C . Int J Mol Sci - 22 (3) (PMID: 33572906) (doi:10.3390/ijms22031336)
13 May | 2019 Targeting the neuronal calcium sensor DREAM with small-molecules for Huntington's disease treatment. Lopez-Hurtado, A, Peraza, DA , Cercos, P, Lagartera, L, Gonzalez, P, Dopazo, XM, Herranz, R, Gonzalez, T , Martin-Martinez, M, Mellström, B, Naranjo, JR, Valenzuela, C , Gutierrez-Rodriguez, M. Sci Rep - 9 (1) : 7260 (PMID: 31086218) (doi:10.1038/s41598-019-43677-7)
18 Mar | 2019 "Activation of Kv7 channels as a novel mechanism for NO/cGMP-induced pulmonary vasodilation". Mondéjar-Parreño, G, Moral-Sanz, J, Barreira, B, De la Cruz, A , Gonzalez, T , Callejo, M, Esquivel-Ruiz, S, Morales-Cano, D, Moreno, L, Valenzuela, C , Perez-Vizcaino, F, Cogolludo, A. Br. J. Pharmacol. (PMID: 30883701) (doi:10.1111/bph.14662)
22 Jan | 2019 Corrigendum to Supplemental Material: 'D242N, a KV7.1 LQTS mutation uncovers a key residue for IKs voltage dependence' [Journal of Molecular and Cellular Cardiology, Volume 110, September 2017, Pages 61-69]. Moreno, C , Oliveras, A, Bartolucci, C, Muñoz, C, de la Cruz, A , Peraza, DA , Gimeno, JR, Martín-Martínez, M, Severi, S, Felipe, A , Lambiase, PD, González, T , Valenzuela, C . J. Mol. Cell. Cardiol. - 128 : 25 (PMID: 30682566) (doi:10.1016/j.yjmcc.2019.01.014)
1 Sep | 2017 D242N, a KV7.1 LQTS mutation uncovers a key residue for IKs voltage dependence. Moreno, C , Oliveras, A, Bartolucci, C, Muñoz, C, de la Cruz, A , Peraza, DA , Gimeno, JR, Martín-Martínez, M, Severi, S, Felipe, A , Lambiase, PD, Gonzalez, T , Valenzuela, C . J. Mol. Cell. Cardiol. - 110 : 61-69 (PMID: 28739325) (doi:10.1016/j.yjmcc.2017.07.009)
31 Mar | 2017 Fludarabine Inhibits KV1.3 Currents in Human B Lymphocytes. de la Cruz, A , Vera-Zambrano, A , Peraza, DA , Valenzuela, C , Zapata, JM , Perez-Chacon, G , Gonzalez, T . Front Pharmacol - 8 : 177 (PMID: 28408885) (doi:10.3389/fphar.2017.00177)
11 Jan | 2016 Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease. Naranjo, JR, Zhang, H, Villar, D , González, P, Dopazo, XM, Morón-Oset, J, Higueras, E, Oliveros, JC, Arrabal, MD, Prieto, A , Cercós, P, González, T , De la Cruz, A , Casado-Vela, J , Rábano, A, Valenzuela, C , Gutierrez-Rodriguez, M, Li, JY, Mellström, B. J. Clin. Invest. (PMID: 26752648) (doi:10.1172/JCI82670)
1 Sep | 2015 A new KCNQ1 mutation at the S5 segment that impairs its association with KCNE1 is responsible for short QT syndrome. Moreno, C , Oliveras, A, de la Cruz, A , Bartolucci, C, Muñoz, C, Salar, E, Gimeno, JR, Severi, S, Comes, N, Felipe, A , González, T , Lambiase, P, Valenzuela, C . Cardiovasc. Res. - 107 (4) : 613-623 (PMID: 26168993) (doi:10.1093/cvr/cvv196)
1 Nov | 2014 PKC inhibition results in a Kv 1.5 + Kv β1.3 pharmacology closer to Kv 1.5 channels. Macías, A , de la Cruz, A , Prieto, A , Peraza, DA , Tamkun, MM, González, T , Valenzuela, C . Br. J. Pharmacol. - 171 (21) : 4914-4926 (PMID: 24946104) (doi:10.1111/bph.12822)
1 Nov | 2012 Stereoselective interactions between local anesthetics and ion channels. Valenzuela, C , Moreno, C , de la Cruz, A , Macías, Á , Prieto, Á , González, T . Chirality - 24 (11) : 944-950 (PMID: 22674834) (doi:10.1002/chir.22051)
9 Jul | 2012 Effects of n-3 Polyunsaturated Fatty Acids on Cardiac Ion Channels. Moreno, C , Macías, A , Prieto, A , de la Cruz, A , González, T , Valenzuela, C . Front Physiol - 3 : 245 (PMID: 22934003) (doi:10.3389/fphys.2012.00245)
15 Jun | 2012 Protein kinase C (PKC) activity regulates functional effects of Kvβ1.3 subunit on KV1.5 channels: identification of a cardiac Kv1.5 channelosome. David, M , Macías, Á , Moreno, C , Prieto, Á , Martínez-Mármol, R, Vicente, R, González, T , Felipe, A , Tamkun, MM, Valenzuela, C . J. Biol. Chem. - 287 (25) : 21416-21428 (PMID: 22547057) (doi:10.1074/jbc.M111.328278)
1 Jul | 2011 Ceramide inhibits Kv currents and contributes to TP-receptor-induced vasoconstriction in rat and human pulmonary arteries. Moral-Sanz, J, Gonzalez, T , Menendez, C, David, M , Moreno, L, Macias, A , Cortijo, J, Valenzuela, C , Perez-Vizcaino, F, Cogolludo, A. Am. J. Physiol., Cell Physiol. - 301 (1) : C186-94 (PMID: 21490312) (doi:10.1152/ajpcell.00243.2010)
1 Dec | 2010 Celecoxib blocks cardiac Kv1.5, Kv4.3 and Kv7.1 (KCNQ1) channels: effects on cardiac action potentials. Macías, A , Moreno, C , Moral-Sanz, J, Cogolludo, A, David, M , Alemanni, M, Pérez-Vizcaíno, F, Zaza, A, Valenzuela, C , González, T . J. Mol. Cell. Cardiol. - 49 (6) : 984-992 (PMID: 20858500) (doi:10.1016/j.yjmcc.2010.09.012)
15 Sep | 2010 Immunomodulatory effects of diclofenac in leukocytes through the targeting of Kv1.3 voltage-dependent potassium channels. Villalonga, N, David, M , Bielańska, J, González, T , Parra, D, Soler, C, Comes, N, Valenzuela, C , Felipe, A . Biochem. Pharmacol. - 80 (6) : 858-866 (PMID: 20488163) (doi:10.1016/j.bcp.2010.05.012)
1 Jun | 2010 Kv1.5-Kv beta interactions: molecular determinants and pharmacological consequences. González, T , David, M , Moreno, C , Macías, A , Valenzuela, C . Mini Rev Med Chem - 10 (7) : 635-642 (PMID: 20500153)
3 Dec | 2008 Structural determinants of Kvbeta1.3-induced channel inactivation: a hairpin modulated by PIP2. Decher, N, Gonzalez, T , Streit, AK, Sachse, FB, Renigunta, V, Soom, M, Heinemann, SH, Daut, J, Sanguinetti, MC. EMBO J. - 27 (23) : 3164-3174 (PMID: 18987637) (doi:10.1038/emboj.2008.231)
11 Apr | 2008 Differential regulation of Na(v)beta subunits during myogenesis. David, M , Martínez-Mármol, R, Gonzalez, T , Felipe, A , Valenzuela, C . Biochem. Biophys. Res. Commun. - 368 (3) : 761-766 (PMID: 18261980) (doi:10.1016/j.bbrc.2008.01.138)
29 Oct | 2007 Kvbeta1.3 reduces the degree of stereoselective bupivacaine block of Kv1.5 channels. Arias, C, Guizy, M, David, M , Marzian, S , González, T , Decher, N, Valenzuela, C . Anesthesiology - 107 (4) : 641-651 (PMID: 17893461) (doi:10.1097/01.anes.0000282100.32923.5c)
1 Oct | 2006 Binding site of a novel Kv1.5 blocker: a "foot in the door" against atrial fibrillation. Decher, N, Kumar, P, Gonzalez, T , Pirard, B, Sanguinetti, MC. Mol. Pharmacol. - 70 (4) : 1204-1211 (PMID: 16835355) (doi:10.1124/mol.106.026203)
7 Nov | 2005 {Omega}-3 and {omega}-6 polyunsaturated fatty acids block HERG channels. Guizy, M, Arias, C, David, M , González, T , Valenzuela, C . Am. J. Physiol., Cell Physiol. - 289 (5) : C1251-60 (PMID: 15987770) (doi:10.1152/ajpcell.00036.2005)
1 Oct | 2005 Structural basis for competition between drug binding and Kvbeta 1.3 accessory subunit-induced N-type inactivation of Kv1.5 channels. Decher, N, Kumar, P, Gonzalez, T , Renigunta, V, Sanguinetti, MC. Mol. Pharmacol. - 68 (4) : 995-991005 (PMID: 16024663) (doi:10.1124/mol.105.011668)
15 Jun | 2004 Novel KChIP2 isoforms increase functional diversity of transient outward potassium currents. Decher, N, Barth, AS, Gonzalez, T , Steinmeyer, K, Sanguinetti, MC. J. Physiol. (Lond.) - 557 (Pt 3) : 761-772 (PMID: 15107477) (doi:10.1113/jphysiol.2004.066720)
1 Apr | 2004 Interaction of angiotensin II with the angiotensin type 2 receptor inhibits the cardiac transient outward potassium current. Caballero, R, Gómez, R, Moreno, I, Nuñez, L, González, T , Arias, C, Guizy, M, Valenzuela, C , Tamargo, J, Delpón, E. Cardiovasc. Res. - 62 (1) : 86-95 (PMID: 15023555) (doi:10.1016/j.cardiores.2003.12.029)
5 Mar | 2003 Effects of propafenone and its main metabolite, 5-hydroxypropafenone, on HERG channels. Arias, C, González, T , Moreno, I, Caballero, R, Delpón, E, Tamargo, J, Valenzuela, C . Cardiovasc. Res. - 57 (3) : 660-669 (PMID: 12618228)
18 Feb | 2003 Spironolactone and its main metabolite, canrenoic acid, block human ether-a-go-go-related gene channels. Caballero, R, Moreno, I, González, T , Arias, C, Valenzuela, C , Delpón, E, Tamargo, J. Circulation - 107 (6) : 889-895 (PMID: 12591761)
1 Feb | 2003 Effects of irbesartan on cloned potassium channels involved in human cardiac repolarization. Moreno, I, Caballero, R, González, T , Arias, C, Valenzuela, C , Iriepa, I, Gálvez, E, Tamargo, J, Delpón, E. J. Pharmacol. Exp. Ther. - 304 (2) : 862-873 (PMID: 12538844) (doi:10.1124/jpet.102.042325)
9 Dec | 2002 Assembly with the Kvbeta1.3 subunit modulates drug block of hKv1.5 channels. González, T , Navarro-Polanco, R, Arias, C, Caballero, R, Moreno, I, Delpón, E, Tamargo, J, Tamkun, MM, Valenzuela, C . Mol. Pharmacol. - 62 (6) : 1456-1463 (PMID: 12435814)
5 Dec | 2002 Effects of levobupivacaine, ropivacaine and bupivacaine on HERG channels: stereoselective bupivacaine block. González, T , Arias, C, Caballero, R, Moreno, I, Delpón, E, Tamargo, J, Valenzuela, C . Br. J. Pharmacol. - 137 (8) : 1269-1279 (PMID: 12466236) (doi:10.1038/sj.bjp.0704978)
1 Oct | 2002 Putative binding sites for benzocaine on a human cardiac cloned channel (Kv1.5). Caballero, R, Moreno, I, González, T , Valenzuela, C , Tamargo, J, Delpón, E. Cardiovasc. Res. - 56 (1) : 104-117 (PMID: 12237171)
20 Sep | 2001 Bupivacaine effects on hKv1.5 channels are dependent on extracellular pH. Longobardo, M, González, T , Caballero, R, Delpón, E, Tamargo, J, Valenzuela, C . Br. J. Pharmacol. - 134 (2) : 359-369 (PMID: 11564654) (doi:10.1038/sj.bjp.0704251)
19 Apr | 2001 Direct effects of candesartan and eprosartan on human cloned potassium channels involved in cardiac repolarization. Caballero, R, Delpón, E, Valenzuela, C , Longobardo, M, González, T , Tamargo, J. Mol. Pharmacol. - 59 (4) : 825-836 (PMID: 11259627)
22 Feb | 2001 Effects of bupivacaine and a novel local anesthetic, IQB-9302, on human cardiac K+ channels. González, T , Longobardo, M, Caballero, R, Delpón, E, Tamargo, J, Valenzuela, C . J. Pharmacol. Exp. Ther. - 296 (2) : 573-583 (PMID: 11160646)
1 Jan | 2001 Stereoselective effects of the enantiomers of a new local anaesthetic, IQB-9302, on a human cardiac potassium channel (Kv1.5). González, T , Longobardo, M, Caballero, R, Delpón, E, Sinisterra, JV, Tamargo, J, Valenzuela, C . Br. J. Pharmacol. - 132 (2) : 385-392 (PMID: 11159686) (doi:10.1038/sj.bjp.0703844)
1 May | 2000 Effects of a quaternary bupivacaine derivative on delayed rectifier K(+) currents. Longobardo, M, González, T , Navarro-Polanco, R, Caballero, R, Delpón, E, Tamargo, J, Snyders, DJ, Tamkun, MM, Valenzuela, C . Br. J. Pharmacol. - 130 (2) : 391-401 (PMID: 10807678) (doi:10.1038/sj.bjp.0703334)