Publications

F
All our publications

*Listed are the articles found in the PubMed database.

Publications by “Lisardo Boscá Gomar”

Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntington's disease.

Chakraborty, A, Sreenivasmurthy, SG, Miller, W, Huai, W, Biswas, T, Mandal, SM, Boscá, L , Krishnan, B, Ghosh, G, Hazra, T.

Endogenous LXR signaling controls pulmonary surfactant homeostasis and prevents lung inflammation.

Hernández-Hernández, I, De La Rosa, JV, Martín-Rodríguez, P, Díaz-Sarmiento, M, Recio, C, Guerra, B, Fernández-Pérez, L, León, TE, Torres, R, Font-Díaz, J, Roig, A, de Mora, F, Boscá, L , Díaz, M, Valledor, AF, Castrillo, A , Tabraue, C.

Percutaneous pulmonary thrombectomy with aspiration catheters in patients with high-risk pulmonary embolism and absolute contraindication to systemic thrombolysis.

Tébar, D, Jurado-Román, A, Jiménez-Valero, S, Galeote, G, Gonzálvez, A, Rivero, B, García, A, Añón Elizalde, JM, Lorenzo, A, Fernández Capitán, C, Torres, R, Soto, C, Alcolea, S, Rosillo, S, Caro Codón, J, Arbas, E, Tejera, F, Plaza, I, Boscá, L , Moreno, R.

Experience with the ACURATE neo and neo2 transcatheter aortic valves in Spain. The PRECISA (PRospective Evaluation Complementing Investigation with ACURATE devices) registry.

Tébar, D, Carrillo, X, García Del Blanco, B, Gómez-Hospital, JA, Nombela, L, Molina, E, Galeote, G, Vilalta, V, Serra-García, V, Carol, GM, Jiménez-Valero, S, Fernandez-Nofrerias, E, Calabuig-Goena, Á, Jurado-Román, A, Sánchez-Recalde, Á, Velasco, MF, Bosca, L , Moreno, R.

Biomarkers in Contrast-Induced Acute Kidney Injury: Towards A New Perspective.

González-Nicolás, MÁ, González-Guerrero, C, Goicoechea, M, Boscá, L , Valiño-Rivas, L, Lázaro, A.

A glycolytic metabolite restores DNA repair activity of polynucleotide kinase 3'-phosphatase in polyglutamine (PolyQ) diseases.

Chakraborty, A, Miller, W, Huai, W, Biswas, T, Mohan Mandal, S, Bosca, L , Ghosh, G, Hazra, T.

Quantitative Proteomics Analysis Reveals That Cyclooxygenase-2 Modulates Mitochondrial Respiratory Chain Complex IV in Cardiomyocytes.

Alvarez, MS, Núñez, E, Fuertes-Agudo, M, Cucarella, C, Fernandez-Velasco, M, Boscá, L , Vázquez, J, Rossignol, R, Martin-Sanz, P , Casado, M.

Specialized Proresolving Mediators Protect Against Experimental Autoimmune Myocarditis by Modulating Ca2+ Handling and NRF2 Activation.

Val-Blasco, A, Prieto, P , Jaén, RI , Gil-Fernández, M , Pajares, M , Domenech, N, Terrón, V , Tamayo, M , Jorge, I, Vázquez, J, Bueno-Sen, A, Vallejo-Cremades, MT, Pombo-Otero, J, Sanchez-García, S , Ruiz-Hurtado, G, Gómez, AM, Zaragoza, C, Crespo-Leiro, MG, López-Collazo, E, Cuadrado, A , Delgado, C , Boscá, L , Fernández-Velasco, M .

Tumor stem cells fuse with monocytes to form highly invasive tumor-hybrid cells.

Aguirre, LA, Montalbán-Hernández, K, Avendaño-Ortiz, J, Marín, E, Lozano, R, Toledano, V, Sánchez-Maroto, L, Terrón, V , Valentín, J, Pulido, E, Casalvilla, JC, Rubio, C, Diekhorst, L, Laso-García, F, Del Fresno, C, Collazo-Lorduy, A, Jiménez-Munarriz, B, Gómez-Campelo, P, Llanos-González, E, Fernández-Velasco, M , Rodríguez-Antolín, C, Pérez de Diego, R, Cantero-Cid, R, Hernádez-Jimenez, E, Álvarez, E, Rosas, R, Dies López-Ayllón, B, de Castro, J, Wculek, SK, Cubillos-Zapata, C, Ibáñez de Cáceres, I, Díaz-Agero, P, Gutiérrez Fernández, M, Paz de Miguel, M, Sancho, D, Schulte, L, Perona, R , Belda-Iniesta, C , Boscá, L , López-Collazo, E.

GRK2 levels in myeloid cells modulate adipose-liver crosstalk in high fat diet-induced obesity.

Vila-Bedmar, R, Cruces-Sande, M, Arcones, AC, Willemen, HLDM, Prieto, P , Moreno-Indias, I, Díaz-Rodríguez, D, Francisco, S, Jaén, RI , Gutiérrez-Repiso, C, Heijnen, CJ, Boscá, L , Fresno, M, Kavelaars, A, Mayor, F, Murga, C.

CIBER-CLAP (CIBERCV Cardioprotection Large Animal Platform): A multicenter preclinical network for testing reproducibility in cardiovascular interventions.

Rossello, X, Rodriguez-Sinovas, A, Vilahur, G, Crisóstomo, V, Jorge, I, Zaragoza, C, Zamorano, JL, Bermejo, J, Ordoñez, A, Boscá, L , Vázquez, J, Badimón, L, Sánchez-Margallo, FM, Fernández-Avilés, F, Garcia-Dorado, D, Ibanez, B.

GQ-11: A new PPAR agonist improves obesity-induced metabolic alterations in LDLr-/- mice.

Silva, JC, de Oliveira, EM, Turato, WM, Trossini, GHG, Maltarollo, VG, Pitta, MGR, Pitta, IR, de Las Heras, B, Boscá, L , Rudnicki, M, Abdalla, DSP.

Mild and Short-Term Caloric Restriction Prevents Obesity-Induced Cardiomyopathy in Young Zucker Rats without Changing in Metabolites and Fatty Acids Cardiac Profile.

Ruiz-Hurtado, G, García-Prieto, CF, Pulido-Olmo, H, Velasco-Martín, JP, Villa-Valverde, P, Fernández-Valle, ME, Boscá, L , Fernández-Velasco, M , Regadera, J, Somoza, B, Fernández-Alfonso, MS.

New PPARγ partial agonist improves obesity-induced metabolic alterations and atherosclerosis in LDLr(-/-) mice.

Silva, JC, César, FA, de Oliveira, EM, Turato, WM, Tripodi, GL, Castilho, G, Machado-Lima, A, de Las Heras, B, Boscá, L , Rabello, MM, Hernandes, MZ, Pitta, MG, Pitta, IR, Passarelli, M, Rudnicki, M, Abdalla, DS.

Epigenetics override pro-inflammatory PTGS transcriptomic signature towards selective hyperactivation of PGE2 in colorectal cancer.

Cebola, I, Custodio, J, Muñoz, M, Díez-Villanueva, A, Paré, L, Prieto, P , Aussó, S, Coll-Mulet, L, Boscá, L , Moreno, V, Peinado, MA.

A labdane diterpene exerts ex vivo and in vivo cardioprotection against post-ischemic injury: involvement of AKT-dependent mechanisms.

Cuadrado-Berrocal, I, Gómez-Gaviro, MV, Benito, Y, Barrio, A, Bermejo, J, Fernández-Santos, ME, Sánchez, PL, Desco, M, Fernández-Avilés, F, Fernández-Velasco, M , Boscá, L , de Las Heras, B.

NFκB2/p100 is a key factor for endotoxin tolerance in human monocytes: a demonstration using primary human monocytes from patients with sepsis.

Cubillos-Zapata, C, Hernández-Jiménez, E, Toledano, V, Esteban-Burgos, L, Fernández-Ruíz, I, Gómez-Piña, V, Del Fresno, C, Siliceo, M, Prieto-Chinchiña, P, Pérez de Diego, R, Boscá, L , Fresno, M, Arnalich, F, López-Collazo, E.

Mitochondrial DAMPs induce endotoxin tolerance in human monocytes: an observation in patients with myocardial infarction.

Fernández-Ruiz, I, Arnalich, F, Cubillos-Zapata, C, Hernández-Jiménez, E, Moreno-González, R, Toledano, V, Fernández-Velasco, M , Vallejo-Cremades, MT, Esteban-Burgos, L, de Diego, RP, Llamas-Matias, MA, García-Arumi, E, Martí, R, Boscá, L , Andreu, AL, López-Sendón, JL, López-Collazo, E.

2-deoxy-2-[18F]fluoro-D-mannose positron emission tomography imaging in atherosclerosis.

Tahara, N, Mukherjee, J, de Haas, HJ, Petrov, AD, Tawakol, A, Haider, N, Tahara, A, Constantinescu, CC, Zhou, J, Boersma, HH, Imaizumi, T, Nakano, M, Finn, A, Fayad, Z, Virmani, R, Fuster, V, Bosca, L , Narula, J.

Protein kinase C (PKC)ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts.

García-Hoz, C, Sánchez-Fernández, G, García-Escudero, R, Fernández-Velasco, M , Palacios-García, J, Ruiz-Meana, M, Díaz-Meco, MT, Leitges, M, Moscat, J, García-Dorado, D, Boscá, L , Mayor, F, Ribas, C.

Anti-inflammatory and antioxidant properties of a new arylidene-thiazolidinedione in macrophages.

Faine, LA, Rudnicki, M, César, FA, Heras, BL, Boscá, L , Souza, ES, Hernandes, MZ, Galdino, SL, Lima, MC, Pitta, IR, Abdalla, DS.

Cilastatin attenuates cisplatin-induced proximal tubular cell damage.

Camano, S, Lazaro, A, Moreno-Gordaliza, E, Torres, AM, de Lucas, C, Humanes, B, Lazaro, JA, Milagros Gomez-Gomez, M, Bosca, L , Tejedor, A.

Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression.

Núñez, V, Alameda, D, Rico, D, Mota, R, Gonzalo, P, Cedenilla, M, Fischer, T, Boscá, L , Glass, CK, Arroyo, AG, Ricote, M.

Kaurane diterpenes protect against apoptosis and inhibition of phagocytosis in activated macrophages.

de las Heras, B, Hortelano, S, Girón, N, Bermejo, P, Rodríguez, B, Boscá, L .

Identification of conserved domains in the promoter regions of nitric oxide synthase 2: implications for the species-specific transcription and evolutionary differences.

Rico, D, Vaquerizas, JM, Dopazo, H, Boscá, L .

Atherogenesis takes place in cholesterol-fed rabbits when circulating concentrations of endogenous cortisol are increased and inflammation suppressed.

de Prada, TP, Pozzi, AO, Coronado, MT, Pounchard, MA, Gonzalez, P, Boscá, L , Fantidis, P.

TLR4-mediated survival of macrophages is MyD88 dependent and requires TNF-alpha autocrine signalling.

Lombardo, E, Alvarez-Barrientos, A, Maroto, B, Boscá, L , Knaus, UG.

Animal models for the study of liver regeneration: role of nitric oxide and prostaglandins.

Hortelano, S, Zeini, M, Casado, M, Martín-Sanz, P , Boscá, L .

Cyclooxygenase 2: understanding the pathophysiological role through genetically altered mouse models.

Martín Sanz, P, Hortelano, S, Bosca, L , Casado, M.

Specific contribution of p19(ARF) to nitric oxide-dependent apoptosis.

Zeini, M, Través, PG , López-Fontal, R, Pantoja, C, Matheu, A, Serrano, M, Boscá, L , Hortelano, S.

The flavonoid quercetin induces apoptosis and inhibits JNK activation in intimal vascular smooth muscle cells.

Perez-Vizcaino, F, Bishop-Bailley, D, Lodi, F, Duarte, J, Cogolludo, A, Moreno, L, Bosca, L , Mitchell, JA, Warner, TD.

Involvement of mitogen-activated protein kinases in the symbiosis Bradyrhizobium-Lupinus.

Fernandez-Pascual, M, Lucas, MM, de Felipe, MR, Boscá, L , Hirt, H, Golvano, MP.

Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms.

Pereira, MP, Hurtado, O, Cárdenas, A, Boscá, L , Castillo, J, Dávalos, A, Vivancos, J, Serena, J, Lorenzo, P, Lizasoain, I, Moro, MA.

The nonthiazolidinedione PPARgamma agonist L-796,449 is neuroprotective in experimental stroke.

Pereira, MP, Hurtado, O, Cárdenas, A, Alonso-Escolano, D, Boscá, L , Vivancos, J, Nombela, F, Leza, JC, Lorenzo, P, Lizasoain, I, Moro, MA.

Assessment of a dual regulatory role for NO in liver regeneration after partial hepatectomy: protection against apoptosis and retardation of hepatocyte proliferation.

Zeini, M, Hortelano, S, Través, PG , Gómez-Valadés, AG, Pujol, A, Perales, JC, Bartrons, R, Boscá, L .

A new family of synthetic diterpenes that regulates cytokine synthesis by inhibiting IkappaBalpha phosphorylation.

Chao, TH, Lam, T, Vong, BG, Través, PG , Hortelano, S, Chowdhury, C, Bahjat, FR, Lloyd, GK, Moldawer, LL, Boscá, L , Palladino, MA, Theodorakis, EA.

PGE1-induced NO reduces apoptosis by D-galactosamine through attenuation of NF-kappaB and NOS-2 expression in rat hepatocytes.

Siendones, E, Fouad, D, Díaz-Guerra, MJ, de la Mata, M, Boscá, L , Muntané, J.

Increased intrahepatic cyclooxygenase 2, matrix metalloproteinase 2, and matrix metalloproteinase 9 expression is associated with progressive liver disease in chronic hepatitis C virus infection: role of viral core and NS5A proteins.

Núñez, O, Fernández-Martínez, A, Majano, PL, Apolinario, A, Gómez-Gonzalo, M, Benedicto, I, López-Cabrera, M, Boscá, L , Clemente, G, García-Monzón, C, Martín-Sanz, P .

The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras.

Oliva, JL, Zarich, N, Martínez, N, Jorge, R, Castrillo, A , Azañedo, M, García-Vargas, S, Gutiérrez-Eisman, S, Juarranz, A, Boscá, L , Gutkind, JS, Rojas, JM.

Induction of nitric oxide synthase-2 proceeds with the concomitant downregulation of the endogenous caveolin levels.

Navarro-Lérida, I, Portolés, MT, Barrientos, AA, Gavilanes, F, Boscá, L , Rodríguez-Crespo, I.

Sustained nitric oxide delivery delays nitric oxide-dependent apoptosis in macrophages: contribution to the physiological function of activated macrophages.

Hortelano, S, Través, PG , Zeini, M, Alvarez, AM, Boscá, L .

Induction of cyclooxygenase-2 accounts for restraint stress-induced oxidative status in rat brain.

Madrigal, JL, Moro, MA, Lizasoain, I, Lorenzo, P, Fernández, AP, Rodrigo, J, Boscá, L , Leza, JC.

Terpenoids: sources, structure elucidation and therapeutic potential in inflammation.

de las Heras, B, Rodríguez, B, Boscá, L , Villar, AM.

Ammonia prevents glutamate-induced but not low K(+)-induced apoptosis in cerebellar neurons in culture.

Llansola, M, Boscá, L , Felipo, V, Hortelano, S.

The nNOS inhibitor, AR-R17477AR, prevents the loss of NF68 immunoreactivity induced by methamphetamine in the mouse striatum.

Sanchez, V, Zeini, M, Camarero, J, O'Shea, E, Bosca, L , Green, AR, Colado, MI.

PKCepsilon is a permissive link in integrin-dependent IFN-gamma signalling that facilitates JAK phosphorylation of STAT1.

Ivaska, J, Bosca, L , Parker, PJ.

Selective inhibitors of cyclooxygenase-2 delay the activation of nuclear factor kappa B and attenuate the expression of inflammatory genes in murine macrophages treated with lipopolysaccharide.

Callejas, NA, Fernández-Martínez, A, Castrillo, A , Boscá, L , Martín-Sanz, P .

Potentiation of protein kinase C zeta activity by 15-deoxy-delta(12,14)-prostaglandin J(2) induces an imbalance between mitogen-activated protein kinases and NF-kappa B that promotes apoptosis in macrophages.

Castrillo, A , Través, PG , Martín-Sanz, P , Parkinson, S, Parker, PJ, Boscá, L .

Nitric oxide and resolution of inflammation.

Hortelano, S, Zeini, M, Boscá, L .

Coexistence of translocated cytochrome c and nitrated protein in neurons of the rat cerebral cortex after oxygen and glucose deprivation.

Alonso, D, Encinas, JM, Uttenthal, LO, Boscá, L , Serrano, J, Fernández, AP, Castro-Blanco, S, Santacana, M, Bentura, ML, Richart, A, Fernández-Vizarra, P, Rodrigo, J.

Interleukin-4 and interleukin-10 modulate nuclear factor kappaB activity and nitric oxide synthase-2 expression in Theiler's virus-infected brain astrocytes.

Molina-Holgado, E, Arévalo-Martín, A, Castrillo, A , Boscá, L , Vela, JM, Guaza, C.

Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection.

Castrillo, A , Pennington, DJ, Otto, F, Parker, PJ, Owen, MJ, Boscá, L .

Interferon (IFN)-gamma and Herpes simplex virus/tumor necrosis factor-alpha synergistically induce nitric oxide synthase 2 in macrophages through cooperative action of nuclear factor-kappa B and IFN regulatory factor-1.

Paludan, SR, Malmgaard, L, Ellermann-Eriksen, S, Boscá, L , Mogensen, SC.

Up-regulation of TNF-alpha convertase (TACE/ADAM17) after oxygen-glucose deprivation in rat forebrain slices.

Hurtado, O, Cárdenas, A, Lizasoain, I, Boscá, L , Leza, JC, Lorenzo, P, Moro, MA.

Inhibition of the nuclear factor kappa B (NF-kappa B) pathway by tetracyclic kaurene diterpenes in macrophages. Specific effects on NF-kappa B-inducing kinase activity and on the coordinate activation of ERK and p38 MAPK.

Castrillo, A , de Las Heras, B, Hortelano, S, Rodriguez, B, Villar, A, Bosca, L .

Inducible nitric oxide synthase expression in brain cortex after acute restraint stress is regulated by nuclear factor kappaB-mediated mechanisms.

Madrigal, JL, Moro, MA, Lizasoain, I, Lorenzo, P, Castrillo, A , Boscá, L , Leza, JC.

Potentiation by nitric oxide of cyclosporin A and FK506-induced apoptosis in renal proximal tubule cells.

Hortelano, S, Castilla, M, Torres, AM, Tejedor, A, Boscá, L .

Contribution of cyclopentenone prostaglandins to the resolution of inflammation through the potentiation of apoptosis in activated macrophages.

Hortelano, S, Castrillo, A , Alvarez, AM, Boscá, L .

Regulation of cyclooxygenase 2 expression in hepatocytes by CCAAT/enhancer-binding proteins.

Callejas, NA, Boscá, L , Williams, CS, DuBOIS, RN, Martín-Sanz, P .

Implication of glutamate in the expression of inducible nitric oxide synthase after oxygen and glucose deprivation in rat forebrain slices.

Cárdenas, A, Moro, MA, Hurtado, O, Leza, JC, Lorenzo, P, Castrillo, A , Bodelón, OG, Boscá, L , Lizasoain, I.

Mechanisms of the neuroprotective effect of aspirin after oxygen and glucose deprivation in rat forebrain slices.

Moro, MA, De Alba, J, Cárdenas, A, De Cristóbal, J, Leza, JC, Lizasoain, I, Díaz-Guerra, MJ, Boscá, L , Lorenzo, P.

Inhibition of IkappaB kinase and IkappaB phosphorylation by 15-deoxy-Delta(12,14)-prostaglandin J(2) in activated murine macrophages.

Castrillo, A , Díaz-Guerra, MJ, Hortelano, S, Martín-Sanz, P , Boscá, L .

Chronic stress induces the expression of inducible nitric oxide synthase in rat brain cortex.

Olivenza, R, Moro, MA, Lizasoain, I, Lorenzo, P, Fernández, AP, Rodrigo, J, Boscá, L , Leza, JC.

Inhibitory effect of IGF-I on type 2 nitric oxide synthase expression in Ins-1 cells and protection against activation-dependent apoptosis: involvement of phosphatidylinositol 3-kinase.

Castrillo, A , Bodelón, OG, Boscá, L .

Nitric oxide induces tyrosine nitration and release of cytochrome c preceding an increase of mitochondrial transmembrane potential in macrophages.

Hortelano, S, Alvarez, AM, Boscá, L .

Requirement of nuclear factor kappaB for the constitutive expression of nitric oxide synthase-2 and cyclooxygenase-2 in rat trophoblasts.

Callejas, NA, Casado, M, Boscá, L , Martín-Sanz, P .

Presence of a nitric oxide synthase inhibitor in the graft efflux during reperfusion in human liver transplantation.

Martín-Sanz, P , Boscá, L , Olmedilla, L, Perez-Peña, J, Garutti, I, Sanz, J, Calleja, J, Avellanal, M, Ortega, A, Aleixandre, A, Barrigón, S.

Mechanisms of nitric oxide-dependent apoptosis: involvement of mitochondrial mediators.

Boscá, L , Hortelano, S.

Down-regulation of neuronal nitric oxide synthase by nitric oxide after oxygen-glucose deprivation in rat forebrain slices.

De Alba, J, Cárdenas, A, Moro, MA, Leza, JC, Lorenzo, P, Boscá, L , Lizasoain, I.

Interferon-alpha/beta inhibits the apoptosis induced by lipopolysaccharide and interferon-gamma in murine peritoneal macrophages.

López-Collazo, E, Hortelano, S, Boscá, L .

The c-erbA alpha protooncogene induces apoptosis in glial cells via a protein kinase C- and bcl-2-suppressible mechanism.

Llanos, S, Caelles, C , Azorín, I, Renau-Piqueras, J, Fernández-Luna, JL, Boscá, L , Muñoz, A .

Suppression of HIV-1 infection in linomide-treated SCID-hu-PBL mice.

del Real, G, Llorente, M, Boscá, L , Hortelano, S, Serrano, A, Lucas, P, Gómez, L, Torán, JL, Redondo, C, Martínez, C.

Triggering of peritoneal macrophages with IFN-alpha/beta attenuates the expression of inducible nitric oxide synthase through a decrease in NF-kappaB activation.

López-Collazo, E, Hortelano, S, Rojas, A, Boscá, L .

Neuronal expression of inducible nitric oxide synthase after oxygen and glucose deprivation in rat forebrain slices.

Moro, MA, De Alba, J, Leza, JC, Lorenzo, P, Fernández, AP, Bentura, ML, Boscá, L , Rodrigo, J, Lizasoain, I.

Differential regulation of nitric oxide synthase mRNA expression by lipopolysaccharide and pro-inflammatory cytokines in fetal hepatocytes treated with cycloheximide.

Casado, M, Díaz-Guerra, MJ, Boscá, L , Martín-Sanz, P .

Nuclear factor kappaB is required for the transcriptional control of type II NO synthase in regenerating liver.

Díaz-Guerra, MJ, Velasco, M, Martín-Sanz, P , Boscá, L .

Rapid Up-regulation of IkappaBbeta and abrogation of NF-kappaB activity in peritoneal macrophages stimulated with lipopolysaccharide.

Velasco, M, Díaz-Guerra, MJ, Martín-Sanz, P , Alvarez, A, Boscá, L .

Requirement of nitric oxide and calcium mobilization for the induction of apoptosis in adrenal vascular endothelial cells.

López-Collazo, E, Mateo, J, Miras-Portugal, MT, Boscá, L .

Nitric oxide induces apoptosis via triggering mitochondrial permeability transition.

Hortelano, S, Dallaporta, B, Zamzami, N, Hirsch, T, Susin, SA, Marzo, I, Boscá, L , Kroemer, G.

Involvement of nitric oxide synthesis in hepatic perturbations induced in rats by a necrogenic dose of thioacetamide.

Díez-Fernández, C, Sanz, N, Boscá, L , Hortelano, S, Cascales, M.

Expression of the calcium-independent cytokine-inducible (iNOS) isoform of nitric oxide synthase in rat placenta.

Casado, M, D-iaz-Guerra, MJ, Rodrigo, J, Fernández, AP, Boscá, L , Martín-Sanz, P .

Macrophage triggering with cecropin A and melittin-derived peptides induces type II nitric oxide synthase expression.

Velasco, M, Díaz-Guerra, MJ, Díaz-Achirica, P, Andreu, D, Rivas, L, Boscá, L .

6-Mercaptopurine decreases the Bcl-2/Bax ratio and induces apoptosis in activated splenic B lymphocytes.

Hortelano, S, Boscá, L .

Linomide administration to mice attenuates the induction of nitric oxide synthase elicited by lipopolysaccharide-activated macrophages and prevents nephritis in MRL/Mp-lpr/lpr mice.

Hortelano, S, Díaz-Guerra, MJ, Gonzalez-García, A, Leonardo, E, Gamallo, C , Boscá, L , Martínez-A, C.

Up-regulation of protein kinase C-epsilon promotes the expression of cytokine-inducible nitric oxide synthase in RAW 264.7 cells.

Díaz-Guerra, MJ, Bodelón, OG, Velasco, M, Whelan, R, Parker, PJ, Boscá, L .

Evidence for common mechanisms in the transcriptional control of type II nitric oxide synthase in isolated hepatocytes. Requirement of NF-kappaB activation after stimulation with bacterial cell wall products and phorbol esters.

Díaz-Guerra, MJ, Velasco, M, Martín-Sanz, P , Boscá, L .

Characterization of nitric oxide dependent changes in carbohydrate hepatic metabolism during septic shock.

Casada, M, Dìaz-Guerra, MJ, Boscà, L , Martìn-Sanz, P .

CD53 antigen and epidermal growth factor induce similar changes in the pattern of phorbol ester binding in a B cell lymphoma.

Barcia, R, García-Vargas, S, Boscá, L , Lazo, PA.

Multiple forms of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase are expressed in perinatal rat liver.

Casado, M, Boscá, L , Martín-Sanz, P .

Characterization of signals leading to clonal expansion or to cell death during lymphocyte B cell activation.

Bosca, L , Stauber, C, Hortelano, S, Baixeras, E, Martinez, C.

Epidermal growth factor inhibits cytokine-dependent nitric oxide synthase expression in hepatocytes.

Terenzi, F, Casado, M, Martín-Sanz, P , Boscá, L .

Nitric oxide synthesis in rat peritoneal macrophages is induced by IgE/DNP complexes and cyclic AMP analogues. Evidence in favor of a common signaling mechanism.

Alonso, A, Carvalho, J, Alonso-Torre, SR, Núñez, L, Boscá, L , Sánchez Crespo, M.

Splenic B lymphocyte programmed cell death is prevented by nitric oxide release through mechanisms involving sustained Bcl-2 levels.

Genaro, AM, Hortelano, S, Alvarez, A, Martínez, C, Boscá, L .

Bacterial lipopeptides induce nitric oxide synthase and promote apoptosis through nitric oxide-independent pathways in rat macrophages.

Terenzi, F, Díaz-Guerra, MJ, Casado, M, Hortelano, S, Leoni, S, Boscá, L .

Nitric oxide is released in regenerating liver after partial hepatectomy.

Hortelano, S, Dewez, B, Genaro, AM, Díaz-Guerra, MJ, Boscá, L .

Platelet-activating factor: the effector of protein-rich plasma extravasation and nitric oxide synthase induction in rat immune complex peritonitis.

Steil, AA, Garcia Rodriguez, MC, Alonso, A, Crespo, MS, Bosca, L .

Protein kinase C (PKC)-induced PKC degradation: a model for down-regulation.

Parker, PJ, Bosca, L , Dekker, L, Goode, NT, Hajibagheri, N, Hansra, G.

[Changes in distribution and isoenzymatic expression of protein kinase C in B lymphocytes induced by alloantigenic stimulation].

Genaro, AM, Hortelano, S, Boscá, L .

From apoptosis to autoimmunity: insights from the signaling pathways leading to proliferation or to programmed cell death.

Baixeras, E, Bosca, L , Stauber, C, Gonzalez, A, Carrera, AC, Gonzalo, JA, Martinez, C.

Cocaine-induced liver injury in mice elicits specific changes in DNA ploidy and induces programmed death of hepatocytes.

Cascales, M, Alvarez, A, Gascó, P, Fernández-Simón, L, Sanz, N, Boscá, L .

Protein kinase C V3 domain mutants with differential sensitivities to m-calpain are not resistant to phorbol-ester-induced down-regulation.

Junco, M, Webster, C, Crawford, C, Bosca, L , Parker, PJ.

Induction of nitric oxide release by MRC OX-44 (anti-CD53) through a protein kinase C-dependent pathway in rat macrophages.

Boscá, L , Lazo, PA.

Relationship between genomic DNA ploidy and parameters of liver damage during necrosis and regeneration induced by thioacetamide.

Díez-Fernández, C, Boscá, L , Fernández-Simón, L, Alvarez, A, Cascales, M.

Early signals in alloantigen induced B-cell proliferation. Comparison between B-cell triggering by intact allogeneic cells and solubilized alloantigen.

Genaro, AM, Boscá, L .

Sulfonylureas activate glycogen phosphorylase and increase cytosolic free-Ca2+ levels in isolated rat hepatocytes.

López-Alarcón, L, Melián, E, Muñoz-Alonso, MJ , Guijarro, C, Boscá, L , Felíu, JE .

Phorbol esters induce nitric oxide synthase and increase arginine influx in cultured peritoneal macrophages.

Hortelano, S, Genaro, AM, Boscá, L .

Signal transduction pathways involved in B-cell induction.

Baixeras, E, Kroemer, G, Cuende, E, Márquez, C, Boscá, L , Alés Martínez, JE, Martínez, C.

Circular dichroism analysis of ligand-induced conformational changes in protein kinase C. Mechanism of translocation of the enzyme from the cytosol to the membranes and its implications.

Boscá, L , Morán, F.

Differential calcium mobilization by vasopressin, angiotensin II, gastrin-releasing peptide, and adenosine triphosphate in adult and fetal hepatocytes. Relevance for the activation of calcium-dependent enzymes.

Junco, M, Díaz-Guerra, MJ, Boscá, L .

Phorbol esters induce nitric oxide synthase activity in rat hepatocytes. Antagonism with the induction elicited by lipopolysaccharide.

Hortelano, S, Genaro, AM, Boscá, L .

Protein kinase C isoenzymes display differential affinity for phorbol esters. Analysis of phorbol ester receptors in B cell differentiation.

Marquez, C, Martinez, C, Kroemer, G, Bosca, L .

Isoenzymes of carbohydrate metabolism in primary cultures of hepatocytes from thioacetamide-induced rat liver necrosis: responses to growth factors.

Cascales, M, Martin-Sanz, P , Alvarez, A, Sanchez-Pérez, M, Diez Fernández, C, Boscá, L .

Phorbol esters, bombesin and insulin elicit differential responses on the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase system in primary cultures of foetal and adult rat hepatocytes.

Cascales, M, Martin-Sanz, P , Bosca, L .

Inhibition of 6-phosphofructo-2-kinase activity by mercaptopurines.

Mojena, M , Bosca, L , Rider, MH, Rousseau, GG, Hue, L.

Oleic acid promotes changes in the subcellular distribution of protein kinase C in isolated hepatocytes.

Díaz-Guerra, MJ, Junco, M, Boscá, L .

B cell triggering by bacterial lipopeptide involves both translocation and activation of the membrane-bound form of protein kinase C.

Boscá, L , Márquez, C, Martínez, C.

Protein kinase C mobilization in B lymphocytes. Differential isoenzyme translocation upon activation.

Márquez, C, Martínez, C, Boscá, L .

Substrate specificity of protein kinase C inhibitors.

Boscá, L , Junco, M, Díaz-Guerra, MJ.

Lack of translocation of protein kinase C from the cytosol to the membranes in vasopressin-stimulated hepatocytes.

Díaz-Guerra, MJ, Boscá, L .

Substrate-dependent inhibition of protein kinase C by specific inhibitors.

Junco, M, Díaz-Guerra, MJ, Boscá, L .

Identification of an anti-A and anti-B blood group glycosyltransferase antibody after incompatible bone marrow transplant.

Mojena, M , Boscá, L .

Lack of correlation between translocation and biological effects mediated by protein kinase C: an appraisal.

Boscá, L , Márquez, C, Martínez, C.

Oleate-induced translocation of protein kinase C to hepatic microsomal membranes.

Boscá, L , Díaz-Guerra, MJ, Mojena, M .

Translocation of phosphatidate phosphohydrolase from the cytosol to microsomal membranes in thioacetamide-induced liver tumours in rats.

Cascales, C, Boscá, L , Martín-Sanz, P , Brindley, DN, Cascales, M.

Glucagon-induced changes in fructose 2,6-bisphosphate and 6-phosphofructo-2-kinase in cultured rat foetal hepatocytes.

Martin-Sanz, P , Cascales, M, Boscá, L .

Presence of antibody to A- and B-transferases in minor incompatible bone marrow transplant.

Barbolla, L, Mojena, M , Boscá, L .

Age-related changes in the translocation of phosphatidate phosphohydrolase from the cytosol to microsomal membranes in rat liver.

Cascales, C, Boscá, L , Martin, A, Brindley, DN, Cascales, M.

Phorbol 12,13-dibutyrate and mitogens increase fructose 2,6-bisphosphate in lymphocytes. Comparison of lymphocyte and rat-liver 6-phosphofructo-2-kinase.

Bosca, L , Mojena, M , Diaz-Guerra, JM, Marquez, C.

Phorbol ester translocation of protein kinase C in guinea-pig synaptosomes and the potentiation of calcium-dependent glutamate release.

Díaz-Guerra, MJ, Sánchez-Prieto, J, Bosca, L , Pocock, J, Barrie, A, Nicholls, D.

Activation of protein kinase C from B lymphocytes by lipid A.

Boscá, L , Díaz-Guerra, MJ.

Expression of the v-src or v-fps oncogene increases fructose 2,6-bisphosphate in chick-embryo fibroblasts. Novel mechanism for the stimulation of glycolysis by retroviruses.

Bosca, L , Mojena, M , Ghysdael, J, Rousseau, GG, Hue, L.

Effect of glutamine on fructose 2,6-bisphosphate and on glucose metabolism in HeLa cells and in chick-embryo fibroblasts.

Mojena, M , Bosca, L , Hue, L.

Phorbol 12-myristate 13-acetate and insulin increase the concentration of fructose 2,6-bisphosphate and stimulate glycolysis in chicken embryo fibroblasts.

Bosca, L , Rousseau, GG, Hue, L.

The effect of fructose 2,6-bisphosphate on muscle fructose-1,6-bisphosphatase activity.

Bosca, L , Challiss, RA, Newsholme, EA.

Modulation of muscle phosphofructokinase at physiological concentration of enzyme.

Boscá, L , Aragón, JJ , Sols, A.

Difference in glucose sensitivity of liver glycolysis and glycogen synthesis. Relationship between lactate production and fructose 2,6-bisphosphate concentration.

Hue, L, Sobrino, F, Bosca, L .

Biphasic effect of fructose 2,6-bisphosphate on the liver fructose-1,6-bisphosphatase: mechanistic and physiological implications.

Corredor, C, Boscá, L , Sols, A.

Mitochondrial membrane-bound hexokinase of ascites tumor cells. Functional implications of lysine residues studied by modification with imidoesters.

Lazo, PA, Bosca, L .

Specific activation by fructose 2,6-bisphosphate and inhibition by P-enolpyruvate of ascites tumor phosphofructokinase.

Boscá, L , Aragón, JJ , Sols, A.
Ministerio de ciencia, innovación y universidades
Consejo Superior de Investigaciones Científicas
Universidad Autónoma de Madrid
FEDER
Plan de Recuperación, Transformación y Resiliencia
Vicepresidencia, Consejería de Educación y Universidades
Unión Europea Next Generation
worldwidecancerresearch
Agencia Estatal de Investigación
Unión Europea Fondo Social Europeo
Instituto de Salud Carlos iii
España Puede
Confederación de Sociedades Científicas de España
IQNet Certified Quality System
AENOR
SED
FERO

C/ Arturo Duperier 4 | 28029 Madrid (España) | Teléfono +(34) 91 585 4400 | Código DIR3: E02764003