24 mayo | 2025 JNK1 in SF1 neurons regulates the central action of thyroid hormones on hepatic lipid metabolism. Fernández-González, I, Freire-Agulleiro, O, Ferreira, V , Silveira-Loureiro, M, Rial-Pensado, E, Garrido-Gil, P, Martínez, G, Rada, P , Labandeira-García, JL, Mittag, J, González-García, I, Diéguez, C, Nogueiras, R, Valverde, ÁM , Davis, RJ, Sabio, G, Barca-Mayo, O, López, M. Mol Metab (PMID: 40419019) (doi:10.1016/j.molmet.2025.102170)
19 mayo | 2025 Effect of lipotoxic hepatocyte-derived extracellular vesicles in pancreas inflammation: essential role of macrophage TLR4 in beta cell functionality. Alén, R , Garcia-Martinez, I , Cobo-Vuilleumier, N, Fernández-Millán, E, Gallardo-Villanueva, P, Ferreira, V , Izquierdo, M , Moro, MÁ, Lizasoain, I, Nieto, N, Gauthier, BR, Valverde, ÁM . Diabetologia (PMID: 40387904) (doi:10.1007/s00125-025-06445-z)
11 mayo | 2025 Development of SOCS1 mimetics as novel approach to harmonize inflammation, oxidative stress, and fibrogenesis in metabolic dysfunction-associated steatotic liver disease. Bernal, S, Prieto, I , Kavanagh, M, Del Real, IH, La Manna, S, Lázaro, I, Quiceno, H, López-Sanz, L, Picatoste, B, Valdecantos, MP , Mas-Fontao, S, Sala-Vila, A, Valverde, ÁM , Marasco, D, Egido, J, Gómez-Guerrero, C. Redox Biol - 84 : 103670 (PMID: 40373621) (doi:10.1016/j.redox.2025.103670)
3 mar | 2025 Health position paper and redox perspectives - Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases. Cuadrado, A , Cazalla, E , Bach, A, Bathish, B, Naidu, SD, DeNicola, GM, Dinkova-Kostova, AT, Fernández-Ginés, R , Grochot-Przeczek, A, Hayes, JD, Kensler, TW, León, R, Liby, KT, López, MG, Manda, G, Shivakumar, AK, Hakomäki, H, Moerland, JA, Motohashi, H, Rojo, AI , Sykiotis, GP, Taguchi, K, Valverde, ÁM , Yamamoto, M, Levonen, AL. Redox Biol (PMID: 40059038) (doi:10.1016/j.redox.2025.103569)
24 feb | 2025 Platelet C3G protects from liver fibrosis, while enhancing tumor growth through regulation of the immune response. Baquero, C, Iniesta-González, M, Palao, N, Fernández-Infante, C, Cueto-Remacha, M, Mancebo, J, de la Cámara-Fuentes, S, Rodrigo-Faus, M, Valdecantos, MP , Valverde, AM , Sequera, C, Manzano, S, Cuesta, ÁM, Gutierrez-Uzquiza, A, Bragado, P, Guerrero, C, Porras, A. J Pathol (PMID: 39989399) (doi:10.1002/path.6403)
19 ene | 2025 BMP6 participates in the molecular mechanisms involved in APAP hepatotoxicity. Marañón, P, Isaza, SC, Rey, E, Rada, P , García-García, Y, Dear, JW, García-Monzón, C, Valverde, ÁM , Egea, J, González-Rodríguez, Á . Arch Toxicol (PMID: 39827450) (doi:10.1007/s00204-024-03954-5)
28 nov | 2024 The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk. Valdecantos, MP , Ruiz, L , Folgueira, C, Rada, P , Gomez-Santos, B, Solas, M, Hitos, AB , Field, J, Francisco, V , Escalona-Garrido, C , Zagmutt, S, Calderon-Dominguez, M, Mera, P, Garcia-Martinez, I , Maymó-Masip, E, Grajales, D , Alen, R , Mora, A, Sáinz, N, Vides-Urrestarazu, I, Vilarrasa, N, Arbones-Mainar, JM, Zaragoza, C, Moreno-Aliaga, MJ, Aspichueta, P, Fernández-Veledo, S, Vendrell, J, Serra, D, Herrero, L, Schreiber, R, Zechner, R, Sabio, G, Hornigold, D, Rondinone, CM, Jermutus, L, Grimsby, J, Valverde, ÁM . Nat Commun - 15 (1) : 10342 (PMID: 39609390) (doi:10.1038/s41467-024-54080-w)
18 oct | 2024 Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis. Ardanaz, CG, de la Cruz, A, Minhas, PS, Hernández-Martín, N, Pozo, MÁ, Valdecantos, MP , Valverde, ÁM , Villa-Valverde, P, Elizalde-Horcada, M, Puerta, E, Ramírez, MJ, Ortega, JE, Urbiola, A, Ederra, C, Ariz, M, Ortiz-de-Solórzano, C, Fernández-Irigoyen, J, Santamaría, E, Karsenty, G, Brüning, JC, Solas, M. Sci Adv - 10 (42) : eadp1115 (PMID: 39423276) (doi:10.1126/sciadv.adp1115)
12 oct | 2024 Protein Kinase D2 modulates hepatic insulin sensitivity in male mice. Rada, P , Carceller-López, E , Hitos, AB , Gómez-Santos, B, Fernández-Hernández, C, Rey, E, Pose-Utrilla, J , García-Monzón, C, González-Rodríguez, Á , Sabio, G, García, A, Aspichueta, P, Iglesias, T , Valverde, ÁM . Mol Metab (PMID: 39401614) (doi:10.1016/j.molmet.2024.102045)
16 ago | 2024 PPARβ/δ attenuates hepatic fibrosis by reducing SMAD3 phosphorylation and p300 levels via AMPK in hepatic stellate cells. Zhang, M, Barroso, E, Peña, L, Rada, P , Valverde, ÁM , Wahli, W, Palomer, X, Vázquez-Carrera, M. Biomed Pharmacother - 179 : 117303 (PMID: 39153437) (doi:10.1016/j.biopha.2024.117303)
14 jun | 2024 The hepatocyte epidermal growth factor receptor (EGFR) pathway regulates the cellular interactome within the liver fibrotic niche. Gonzalez-Sanchez, E, Vaquero, J, Caballero-Diaz, D, Grzelak, J, Fusté, NP, Bertran, E, Amengual, J, Garcia-Saez, J, Martín-Mur, B, Gut, M, Esteve-Codina, A, Alay, A, Coulouarn, C, Calero-Perez, S, Valdecantos, P , Valverde, AM , Sánchez, A, Herrera, B, Fabregat, I. J Pathol (PMID: 38872438) (doi:10.1002/path.6299)
10 mayo | 2024 Estrogens prevent the hypothalamus-periphery crosstalk induced by olanzapine intraperitoneal treatment in female mice: Effects on brown/beige adipose tissues and liver. Ferreira, V , Folgueira, C, Montes-San Lorenzo, Á , Rodríguez-López, A, Gonzalez-Iglesias, E, Zubiaur, P, Abad-Santos, F, Sabio, G, Rada, P , Valverde, ÁM . Biochim Biophys Acta Mol Basis Dis - 1870 (5) : 167227 (PMID: 38733774) (doi:10.1016/j.bbadis.2024.167227)
8 abr | 2024 Uncovering a Novel Functional Interaction Between Adult Hepatic Progenitor Cells, Inflammation and EGFR Signaling During Bile Acids-Induced Injury. García-Sáez, J, Figueroa-Fuentes, M, González-Corralejo, C, Roncero, C, Lazcanoiturburu, N, Gutiérrez-Uzquiza, Á, Vaquero, J, González-Sánchez, E, Bhutia, K, Calero-Pérez, S , Maina, F, Traba, J, Valverde, ÁM , Fabregat, I, Herrera, B, Sánchez, A. Int J Biol Sci - 20 (7) : 2339-2355 (PMID: 38725853) (doi:10.7150/ijbs.90645)
15 feb | 2024 Inhibition of ALK3-mediated signalling pathway protects against acetaminophen-induced liver injury. Marañón, P, Rey, E, Isaza, SC, Wu, H, Rada, P , Choya-Foces, C, Martínez-Ruiz, A, Martín, MÁ, Ramos, S, García-Monzón, C, Cubero, FJ, Valverde, ÁM , González-Rodríguez, Á . Redox Biol - 71 : 103088 (PMID: 38401290) (doi:10.1016/j.redox.2024.103088)
31 ene | 2024 An altered expression of miR-376a-3p and miR-20a-5p in peripheral blood exosomes regulates the autophagy and inflammatory systemic substrates, and relates to the smoking habit and age in Crohn's disease. Caparrós, E, García-Martinez, I , Pedro Zapater, , Lucía Madero, , Valverde, ÁM , Ana Gutiérrez, , Francés, R. FASEB J - 38 (2) : e23418 (PMID: 38226870) (doi:10.1096/fj.202301761R)
17 ene | 2024 Synergistic Effect of a Flavonoid-Rich Cocoa-Carob Blend and Metformin in Preserving Pancreatic Beta Cells in Zucker Diabetic Fatty Rats. Gallardo-Villanueva, P, Fernández-Marcelo, T, Villamayor, L , Valverde, AM , Ramos, S, Fernández-Millán, E, Martín, MA. Nutrients - 16 (2) (PMID: 38257166) (doi:10.3390/nu16020273)
3 ene | 2024 GDF15 activates AMPK and inhibits gluconeogenesis and fibrosis in the liver by attenuating the TGF-β1/SMAD3 pathway. Jurado-Aguilar, J, Barroso, E, Bernard, M, Zhang, M, Peyman, M, Rada, P , Valverde, ÁM , Wahli, W, Palomer, X, Vázquez-Carrera, M. Metabolism - 152 : 155772 (PMID: 38176644) (doi:10.1016/j.metabol.2023.155772)
3 ene | 2024 Specific targeting of the NRF2/β-TrCP axis promotes beneficial effects in NASH. Fernández-Ginés, R , Encinar, JA, Escoll, M , Carnicero-Senabre, D , Jiménez-Villegas, J , García-Yagüe, ÁJ , González-Rodríguez, Á , Garcia-Martinez, I , M Valverde, Á , Rojo, AI , Cuadrado, A . Redox Biol - 69 : 103027 (PMID: 38184999) (doi:10.1016/j.redox.2024.103027)
28 nov | 2023 Pharmacological and genetic increases in liver NADPH levels ameliorate NASH progression in female mice. Rodriguez-Ramiro, I, Pastor-Fernández, A, López-Aceituno, JL, Garcia-Dominguez, E, Sierra-Ramirez, A, Valverde, AM , Martinez-Pastor, B, Efeyan, A, Gomez-Cabrera, MC, Viña, J, Fernandez-Marcos, PJ. Free Radic Biol Med (PMID: 38036067) (doi:10.1016/j.freeradbiomed.2023.11.019)
10 oct | 2023 Soluble epoxide hydrolase-targeting PROTAC activates AMPK and inhibits endoplasmic reticulum stress. Peyman, M, Barroso, E, Turcu, AL, Estrany, F, Smith, D, Jurado-Aguilar, J, Rada, P , Morisseau, C, Hammock, BD, Valverde, ÁM , Palomer, X, Galdeano, C, Vázquez, S, Vázquez-Carrera, M. Biomed Pharmacother - 168 : 115667 (PMID: 37826940) (doi:10.1016/j.biopha.2023.115667)
30 sep | 2023 Elafibranor upregulates the EMT-inducer S100A4 via PPARβ/δ. Zhang, M, Barroso, E, Ruart, M, Peña, L, Peyman, M, Aguilar-Recarte, D, Montori-Grau, M, Rada, P , Cugat, C, Montironi, C, Zarei, M, Jurado-Aguilar, J, Camins, A, Balsinde, J, Valverde, ÁM , Wahli, W, Palomer, X, Vázquez-Carrera, M. Biomed Pharmacother - 167 : 115623 (PMID: 37783154) (doi:10.1016/j.biopha.2023.115623)
1 ago | 2023 Maresin 1 activates brown adipose tissue and promotes browning of white adipose tissue in mice. Laiglesia, LM, Escoté, X, Sáinz, N, Felix-Soriano, E, Santamaría, E, Collantes, M, Fernández-Galilea, M, Colón-Mesa, I, Martínez-Fernández, L, Quesada-López, T, Quesada-Vázquez, S, Rodríguez-Ortigosa, C, Arbones-Mainar, JM, Valverde, ÁM , Martínez, JA, Dalli, J, Herrero, L, Lorente-Cebrián, S, Villarroya, F, Moreno-Aliaga, MJ. Mol Metab - 74 : 101749 (PMID: 37271337) (doi:10.1016/j.molmet.2023.101749)
1 ago | 2023 Saturated fatty acid-enriched small extracellular vesicles mediate a crosstalk inducing liver inflammation and hepatocyte insulin resistance. Garcia-Martinez, I , Alen, R , Pereira, L, Povo-Retana, A , Astudillo, AM, Hitos, AB , Gomez-Hurtado, I, Lopez-Collazo, E, Boscá, L , Francés, R, Lizasoain, I, Moro, MÁ, Balsinde, J, Izquierdo, M , Valverde, ÁM . JHEP Rep - 5 (8) : 100756 (PMID: 37360906) (doi:10.1016/j.jhepr.2023.100756)
1 jul | 2023 The protective role of peroxisome proliferator-activated receptor gamma in lipotoxic podocytes. Carrasco, AG, Izquierdo-Lahuerta, A, Valverde, ÁM , Ni, L, Flores-Salguero, E, Coward, RJ, Medina-Gómez, G . Biochim Biophys Acta Mol Cell Biol Lipids - 1868 (7) : 159329 (PMID: 37156296) (doi:10.1016/j.bbalip.2023.159329)
12 jun | 2023 Protective effects of the succinate/SUCNR1 axis on damaged hepatocytes in NAFLD. Marsal-Beltran, A, Rodríguez-Castellano, A, Astiarraga, B, Calvo, E, Rada, P , Madeira, A, Rodríguez-Peña, MM, Llauradó, G, Núñez-Roa, C, Gómez-Santos, B, Maymó-Masip, E, Bosch, R, Frutos, MD, Moreno-Navarrete, JM, Ramos-Molina, B, Aspichueta, P, Joven, J, Fernández-Real, JM, Quer, JC, Valverde, ÁM , Pardo, A, Vendrell, J, Ceperuelo-Mallafré, V, Fernández-Veledo, S. Metabolism (PMID: 37315889) (doi:10.1016/j.metabol.2023.155630)
15 mayo | 2023 Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewiring that prevents hepatic steatosis in male mice treated with olanzapine via intraperitoneal: Additional effects of PTP1B inhibition. Ferreira, V , Folgueira, C, García-Altares, M, Guillén, M , Ruíz-Rosario, M, DiNunzio, G, Garcia-Martinez, I , Alen, R , Bookmeyer, C, Jones, JG, Cigudosa, JC, López-Larrubia, P , Correig-Blanchar, X, Davis, RJ, Sabio, G, Rada, P , Valverde, ÁM . Redox Biol - 63 : 102741 (PMID: 37230004) (doi:10.1016/j.redox.2023.102741)
27 abr | 2023 Circulating bone morphogenetic protein 8A is a novel biomarker to predict advanced liver fibrosis. Marañón, P, Isaza, SC, Fernández-García, CE, Rey, E, Gallego-Durán, R, Montero-Vallejo, R, de Cía, JR, Ampuero, J, Valverde, ÁM , Romero-Gómez, M, García-Monzón, C, González-Rodríguez, Á . Biomark Res - 11 (1) : 46 (PMID: 37106416) (doi:10.1186/s40364-023-00489-2)
20 abr | 2023 "MiR-7 controls cholesterol biosynthesis through posttranscriptional regulation of DHCR24 expression". Frutos, MF, Pardo-Marqués, V, Torrecilla-Parra, M, Rada, P , Pérez-García, A, Martín-Martín, Y, de la Peña, G, Gómez, A, Toledano-Zaragoza, A, Gómez-Coronado, D, Casarejos, MJ, Solís, JM, Rotllán, N, Pastor, Ó, Ledesma, MD, Valverde, ÁM , Busto, R, Ramírez, CM. Biochim Biophys Acta Gene Regul Mech (PMID: 37086967) (doi:10.1016/j.bbagrm.2023.194938)
5 feb | 2023 Effects of the second-generation antipsychotic drugs aripiprazole and olanzapine on human adipocyte differentiation. Vranic, M, Ahmed, F, Hetty, S, Sarsenbayeva, A, Ferreira, V , Fanni, G, Valverde, ÁM , Eriksson, JW, Pereira, MJ. Mol Cell Endocrinol - 561 : 111828 (PMID: 36526026) (doi:10.1016/j.mce.2022.111828)
23 nov | 2022 A positive feedback loop between AMPK and GDF15 promotes metformin antidiabetic effects. Aguilar-Recarte, D, Barroso, E, Zhang, M, Rada, P , Pizarro-Delgado, J, Peña, L, Palomer, X, Valverde, ÁM , Wahli, W, Vázquez-Carrera, M. Pharmacol Res (PMID: 36435271) (doi:10.1016/j.phrs.2022.106578)
1 nov | 2022 Lack of EGFR catalytic activity in hepatocytes improves liver regeneration following DDC-induced cholestatic injury by promoting a pro-restorative inflammatory response. Lazcanoiturburu, N, García-Sáez, J, González-Corralejo, C, Roncero, C, Sanz, J, Martín-Rodríguez, C, Valdecantos, MP , Martínez-Palacián, A, Almalé, L, Bragado, P, Calero-Pérez, S , Fernández, A, García-Bravo, M, Guerra, C, Montoliu, L, Segovia, JC, Valverde, ÁM , Fabregat, I, Herrera, B, Sánchez, A. J Pathol - 258 (3) : 312-324 (PMID: 36148647) (doi:10.1002/path.6002)
19 oct | 2022 Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight. Ferreira, V , Folgueira, C, Guillén, M , Zubiaur, P, Navares, M, Sarsenbayeva, A, López-Larrubia, P , Eriksson, JW, Pereira, MJ, Abad-Santos, F, Sabio, G, Rada, P , Valverde, ÁM . Metabolism - 137 : 155335 (PMID: 36272468) (doi:10.1016/j.metabol.2022.155335)
30 sep | 2022 Effects of a Mealworm (Tenebrio molitor) Extract on Metabolic Syndrome-Related Pathologies: In Vitro Insulin Sensitivity, Inflammatory Response, Hypolipidemic Activity and Oxidative Stress. Navarro Del Hierro, J, Cantero-Bahillo, E, Fernández-Felipe, MT, García-Risco, MR, Fornari, T, Rada, P , Doblado, L , Ferreira, V , Hitos, AB , Valverde, ÁM , Monsalve, M , Martin, D. Insects - 13 (10) (PMID: 36292844) (doi:10.3390/insects13100896)
9 jun | 2022 Ptpn1 deletion protects oval cells against lipoapoptosis by favoring lipid droplet formation and dynamics. Barahona, I , Rada, P , Calero-Pérez, S , Grillo-Risco, R, Pereira, L, Soler-Vázquez, MC, LaIglesia, LM, Moreno-Aliaga, MJ, Herrero, L, Serra, D, García-Monzon, C, González-Rodriguez, Á , Balsinde, J, García-García, F, Valdecantos, MP , Valverde, ÁM . Cell Death Differ (PMID: 35681014) (doi:10.1038/s41418-022-01023-x)
16 mayo | 2022 Attenuation of Olanzapine-Induced Endoplasmic Reticulum Stress Improves Insulin Secretion in Pancreatic Beta Cells. Grajales, D , Vázquez, P , Alén, R , Hitos, AB , Valverde, ÁM . Metabolites - 12 (5) (PMID: 35629947) (doi:10.3390/metabo12050443)
24 feb | 2022 Enhanced Wild-Type MET Receptor Levels in Mouse Hepatocytes Attenuates Insulin-Mediated Signaling. Rada, P , Lamballe, F, Carceller-López, E , Hitos, AB , Sequera, C, Maina, F, Valverde, ÁM . Cells - 11 (5) (PMID: 35269415) (doi:10.3390/cells11050793)
21 dic | 2021 The second-generation antipsychotic drug aripiprazole modulates the serotonergic system in pancreatic islets and induces beta cell dysfunction in female mice. Grajales, D , Vázquez, P , Ruíz-Rosario, M, Tudurí, E, Mirasierra, M , Ferreira, V , Hitos, AB , Koller, D, Zubiaur, P, Cigudosa, JC, Abad-Santos, F, Vallejo, M , Quesada, I, Tirosh, B, Leibowitz, G, Valverde, ÁM . Diabetologia (PMID: 34932133) (doi:10.1007/s00125-021-05630-0)
19 oct | 2021 Metformin reduces macrophage HIF1α-dependent proinflammatory signaling to restore brown adipocyte function in vitro. Pescador, N , Francisco, V , Vázquez, P , Esquinas, EM , González-Páramos, C , Valdecantos, MP , García-Martínez, I , Urrutia, AA, Ruiz, L , Escalona-Garrido, C , Foretz, M, Viollet, B, Fernández-Moreno, MÁ , Calle-Pascual, AL, Obregón, MJ , Aragonés, J, Valverde, ÁM . Redox Biol - 48 : 102171 (PMID: 34736121) (doi:10.1016/j.redox.2021.102171)
13 ago | 2021 Increased Hypothalamic Anti-Inflammatory Mediators in Non-Diabetic Insulin Receptor Substrate 2-Deficient Mice. Vinaixa, M, Canelles, S, González-Murillo, Á, Ferreira, V , Grajales, D , Guerra-Cantera, S, Campillo-Calatayud, A, Ramírez-Orellana, M, Yanes, Ó, Frago, LM , Valverde, ÁM , Barrios, V. Cells - 10 (8) (PMID: 34440853) (doi:10.3390/cells10082085)
29 mar | 2021 Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress. Brea, R , Valdecantos, P , Rada, P , Alen, R , García-Monzón, C, Boscá, L , Fuertes-Agudo, M, Casado, M, Martín-Sanz, P , Valverde, ÁM . Aging (Albany NY) - 13 (6) : 7800-7827 (PMID: 33780353) (doi:10.18632/aging.202884)
18 mar | 2021 Anti-Inflammatory (M2) Response Is Induced by a sp2-Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy. Cano-Cano, F, Alcalde-Estévez, E , Gómez-Jaramillo, L, Iturregui, M, Sánchez-Fernández, EM, García Fernández, JM, Ortiz Mellet, C, Campos-Caro, A, López-Tinoco, C, Aguilar-Diosdado, M, Valverde, ÁM , Arroba, AI . Front Immunol - 12 : 632132 (PMID: 33815384) (doi:10.3389/fimmu.2021.632132)
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14 dic | 2020 Aging in male Wistar rats associates with changes in intestinal microbiota, gut structure and cholecystokinin-mediated gut-brain axis function. Rubio, C , Lizárraga, E, Álvarez-Cilleros, D, Pérez-Pardo, P, Sanmartín-Salinas, P, Toledo-Lobo, MV, Alvarez, C, Escrivá, F, Fernández-Lobato, M, Guijarro, LG, Valverde, AM , Carrascosa, JM. J Gerontol A Biol Sci Med Sci (PMID: 33315062) (doi:10.1093/gerona/glaa313)
19 oct | 2020 Defective liver glycogen autophagy related to hyperinsulinemia in intrauterine growth-restricted newborn wistar rats. de Toro-Martín, J, Fernández-Marcelo, T, González-Rodríguez, Á , Escrivá, F, Valverde, ÁM , Álvarez, C, Fernández-Millán, E. Sci Rep - 10 (1) : 17651 (PMID: 33077861) (doi:10.1038/s41598-020-74702-9)
10 oct | 2020 Moderate SIRT1 overexpression protects against inflammation of brown adipose tissue. Escalona-Garrido, C , Vázquez, P , Mera, P, Zagmutt, S, García-Casarrubios, E , Montero-Pedrazuela, A , Rey-Stolle, F, Guadaño-Ferraz, A , Rupérez, FJ, Serra, D, Herrero, L, Obregon, MJ , Valverde, ÁM . Mol Metab (PMID: 33049408) (doi:10.1016/j.molmet.2020.101097)
25 sep | 2020 Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver? Rada, P , González-Rodríguez, Á , García-Monzón, C, Valverde, ÁM . Cell Death Dis - 11 (9) : 802 (PMID: 32978374) (doi:10.1038/s41419-020-03003-w)
11 ago | 2020 Insights Into Extracellular Vesicles as Biomarker of NAFLD Pathogenesis. Garcia-Martinez, I , Alen, R , Rada, P , Valverde, AM . Front Med (Lausanne) - 7 : 395 (PMID: 32850903) (doi:10.3389/fmed.2020.00395)
10 ago | 2020 Effect of Topical Administration of Somatostatin on Retinal Inflammation and Neurodegeneration in an Experimental Model of Diabetes. Hernández, C, Arroba, AI , Bogdanov, P, Ramos, H, Simó-Servat, O, Simó, R, Valverde, AM . J Clin Med - 9 (8) (PMID: 32784955) (doi:10.3390/jcm9082579)
17 jun | 2020 Aripiprazole cytotoxicity coincides with activation of the unfolded protein response in human hepatic cells. Forno, F, Maatuf, Y, Boukeileh, S, Dipta, P, Mahameed, M, Darawshi, O, Ferreira, V , Rada, P , Garcia-Martinez, I , Gross, E, Priel, A, Martinez Valverde, A , Tirosh, B. J. Pharmacol. Exp. Ther. (PMID: 32554435) (doi:10.1124/jpet.119.264481)
6 feb | 2020 Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice. Rubio, C , Puerto, M, García-Rodríquez, JJ, Lu, VB, García-Martínez, I , Alén, R , Sanmartín-Salinas, P, Toledo-Lobo, MV, Saiz, J, Ruperez, J, Barbas, C, Menchén, L, Gribble, FM, Reimann, F, Guijarro, LG, Carrascosa, JM, Valverde, ÁM . Mol Metab - 35 : 100954 (PMID: 32244182) (doi:10.1016/j.molmet.2020.01.018)
1 feb | 2020 Adipose tissue as a target for second-generation (atypical) antipsychotics: A molecular view. Ferreira, V , Grajales, D , Valverde, ÁM . Biochim Biophys Acta Mol Cell Biol Lipids - 1865 (2) : 158534 (PMID: 31672575) (doi:10.1016/j.bbalip.2019.158534)
30 ene | 2020 Metabolic impact of partial hepatectomy in the non-alcoholic steatohepatitis animal model of methionine-choline deficient diet. Carril, E, Valdecantos, MP , Lanzón, B, Angulo, S, Valverde, ÁM , Godzien, J, Rupérez, FJ. J Pharm Biomed Anal - 178 : 112958 (PMID: 31718984) (doi:10.1016/j.jpba.2019.112958)
29 oct | 2019 Second-Generation Antipsychotics and Dysregulation of Glucose Metabolism: Beyond Weight Gain. Grajales, D , Ferreira, V , Valverde, ÁM . Cells - 8 (11) (PMID: 31671770) (doi:10.3390/cells8111336)
1 sep | 2019 Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases. García-Ruiz, I , Blanes Ruiz, N , Rada, P , Pardo, V , Ruiz, L , Blas-García, A, Valdecantos, MP , Grau Sanz, M, Solís Herruzo, JA, Valverde, ÁM . Redox Biol - 26 : 101263 (PMID: 31299613) (doi:10.1016/j.redox.2019.101263)
16 jul | 2019 Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury. Villar-Lorenzo, A , Rada, P , Rey, E, Marañón, P, Arroba, AI , Santamaría, B , Sáiz, J, Rupérez, FJ, Barbas, C, García-Monzón, C, Valverde, ÁM , González-Rodríguez, Á . Dis Model Mech - 12 (7) (PMID: 31262748) (doi:10.1242/dmm.038810)
7 mar | 2019 p38α deficiency restrains liver regeneration after partial hepatectomy triggering oxidative stress and liver injury. Rius-Pérez, S, Tormos, AM, Pérez, S, Finamor, I, Rada, P , Valverde, ÁM , Nebreda, AR, Sastre, J, Taléns-Visconti, R. Sci Rep - 9 (1) : 3775 (PMID: 30846722) (doi:10.1038/s41598-019-39428-3)
15 ene | 2019 Differential effects of metformin glycinate and hydrochloride in glucose production, AMPK phosphorylation and insulin sensitivity in hepatocytes from non-diabetic and diabetic mice. Rada, P , Mosquera, A , Muntané, J, Ferrandiz, F, Rodriguez-Mañas, L, de Pablo, F, González-Canudas, J, Valverde, ÁM . Food Chem. Toxicol. - 123 : 470-480 (PMID: 30414960) (doi:10.1016/j.fct.2018.11.019)
1 dic | 2018 Increased FGF21 in brown adipose tissue of tyrosine hydroxylase heterozygous mice: implications for cold adaptation. Vázquez, P , Hernández-Sánchez, C, Escalona-Garrido, C , Pereira, L, Contreras, C, López, M, Balsinde, J, de Pablo, F, Valverde, ÁM . J. Lipid Res. - 59 (12) : 2308-2320 (PMID: 30352954) (doi:10.1194/jlr.M085209)
7 nov | 2018 Differential Effects of a Glucagon-Like Peptide 1 Receptor Agonist in Non-Alcoholic Fatty Liver Disease and in Response to Hepatectomy. Valdecantos, MP , Ruiz, L , Pardo, V , Castro-Sanchez, L, García-Monzón, C, Lanzón, B, Rupérez, J, Barbas, C, Naylor, J, Trevaskis, JL, Grimsby, J, Rondinone, CM, Valverde, ÁM . Sci Rep - 8 (1) : 16461 (PMID: 30405191) (doi:10.1038/s41598-018-33949-z)
24 sep | 2018 Involvement of G protein-coupled receptor kinase 2 (GRK2) in the development of non-alcoholic steatosis and steatohepatitis in mice and humans. Cruces-Sande, M, Vila-Bedmar, R, Arcones, AC, González-Rodríguez, Á , Rada, P , Gutiérrez-de-Juan, V, Vargas-Castrillón, J, Iruzubieta, P, Sánchez-González, C, Formentini, L, Crespo, J, García-Monzón, C, Martínez-Chantar, ML, Valverde, ÁM , Mayor, F, Murga, C. Biochim Biophys Acta Mol Basis Dis (PMID: 30261289) (doi:10.1016/j.bbadis.2018.09.027)
5 jul | 2018 IGF-1, Inflammation and Retinal Degeneration: A Close Network. Arroba, AI , Campos-Caro, A, Aguilar-Diosdado, M, Valverde, ÁM . Front Aging Neurosci - 10 : 203 (PMID: 30026694) (doi:10.3389/fnagi.2018.00203)
1 jul | 2018 Protection against gamma-radiation injury by protein tyrosine phosphatase 1B. Mojena, M , Pimentel-Santillana, M , Povo-Retana, A , Fernández-García, V , González-Ramos, S , Rada, P , Tejedor, A, Rico, D, Martín-Sanz, P , Valverde, AM , Boscá, L . Redox Biol - 17 : 213-223 (PMID: 29705509) (doi:10.1016/j.redox.2018.04.018)
1 abr | 2018 Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach. Cuadrado, A , Manda, G, Hassan, A, Alcaraz, MJ, Barbas, C, Daiber, A, Ghezzi, P, León, R, López, MG, Oliva, B, Pajares, M , Rojo, AI , Robledinos-Antón, N , Valverde, AM , Guney, E, Schmidt, HHHW. Pharmacol. Rev. - 70 (2) : 348-383 (PMID: 29507103) (doi:10.1124/pr.117.014753)
9 feb | 2018 Imbalance between pro-apoptotic and pro-survival factors in human retinal pericytes in diabetic-like conditions. Beltramo, E, Arroba, AI , Mazzeo, A, Valverde, AM , Porta, M. Acta Ophthalmol - 96 (1) : e19-e26 (PMID: 28127871) (doi:10.1111/aos.13377)
1 feb | 2018 Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease. Zarei, M, Barroso, E, Palomer, X, Dai, J, Rada, P , Quesada-López, T, Escolà-Gil, JC, Cedó, L, Zali, MR, Molaei, M, Dabiri, R, Vázquez, S, Pujol, E, Valverde, ÁM , Villarroya, F, Liu, Y, Wahli, W, Vázquez-Carrera, M. Mol Metab - 8 : 117-131 (PMID: 29289645) (doi:10.1016/j.molmet.2017.12.008)
1 ene | 2018 Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis. González-Rodríguez, Á , Valdecantos, MP , Rada, P , Addante, A, Barahona, I , Rey, E, Pardo, V , Ruiz, L , Laiglesia, LM, Moreno-Aliaga, MJ, García-Monzón, C, Sánchez, A, Valverde, ÁM . Mol Metab - 7 : 132-146 (PMID: 29126873) (doi:10.1016/j.molmet.2017.10.008)
1 ene | 2018 The sp2-iminosugar glycolipid 1-dodecylsulfonyl-5N,6O-oxomethylidenenojirimycin (DSO2-ONJ) as selective anti-inflammatory agent by modulation of hemeoxygenase-1 in Bv.2 microglial cells and retinal explants. Alcalde-Estévez, E , Arroba, AI , Sánchez-Fernández, EM, Mellet, CO, García Fernández, JM, Masgrau, L, Valverde, ÁM . Food Chem. Toxicol. - 111 : 454-466 (PMID: 29191728) (doi:10.1016/j.fct.2017.11.050)
1 nov | 2017 Somatostatin protects human retinal pericytes from inflammation mediated by microglia. Mazzeo, A, Arroba, AI , Beltramo, E, Valverde, AM , Porta, M. Exp. Eye Res. - 164 : 46-54 (PMID: 28734673) (doi:10.1016/j.exer.2017.07.011)
31 oct | 2017 SIRT1 CONTROLS ACETAMINOPHEN HEPATOTOXICITY BY MODULATING INFLAMMATION AND OXIDATIVE STRESS. Rada, P , Pardo, V , Mobasher, M, Garcia, I, Ruiz, L , Gonzalez Rodriguez, A, Sánchez Ramos, C, Muntané, J, Alemany, S , James, LP, Simpson, KJ, Monsalve, M , Valdecantos, MP , Valverde, A . Antioxid. Redox Signal. (PMID: 29084443) (doi:10.1089/ars.2017.7373)
1 jun | 2017 Modulation of microglia in the retina: new insights into diabetic retinopathy. Arroba, AI , Valverde, ÁM . Acta Diabetol - 54 (6) : 527-533 (PMID: 28349217) (doi:10.1007/s00592-017-0984-z)
1 mar | 2017 A novel glucagon-like peptide 1/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice. Valdecantos, MP , Pardo, V , Ruiz, L , Castro-Sánchez, L, Lanzón, B, Fernández-Millán, E, García-Monzón, C, Arroba, AI , González-Rodríguez, Á , Escrivá, F, Álvarez, C, Rupérez, FJ, Barbas, C, Konkar, A, Naylor, J, Hornigold, D, Santos, AD, Bednarek, M, Grimsby, J, Rondinone, CM, Valverde, ÁM . Hepatology - 65 (3) : 950-968 (PMID: 27880981) (doi:10.1002/hep.28962)
6 feb | 2017 p38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and aging. Tormos, AM, Rius-Pérez, S, Jorques, M, Rada, P , Ramirez, L, Valverde, ÁM , Nebreda, ÁR, Sastre, J, Taléns-Visconti, R. PLoS ONE - 12 (2) : e0171738 (PMID: 28166285) (doi:10.1371/journal.pone.0171738)
30 dic | 2016 Somatostatin protects photoreceptor cells against high glucose-induced apoptosis. Arroba, AI , Mazzeo, A, Cazzoni, D, Beltramo, E, Hernández, C, Porta, M, Simó, R, Valverde, ÁM . Mol. Vis. - 22 : 1522-1531 (PMID: 28050125)
15 dic | 2016 Friedelane-type triterpenoids as selective anti-inflammatory agents by regulation of differential signaling pathways in LPS-stimulated macrophages. Villar-Lorenzo, A , Ardiles, AE, Arroba, AI , Hernández-Jiménez, E, Pardo, V , López-Collazo, E, Jiménez, IA, Bazzocchi, IL, González-Rodríguez, Á , Valverde, ÁM . Toxicol. Appl. Pharmacol. - 313 : 57-67 (PMID: 27751938) (doi:10.1016/j.taap.2016.10.004)
1 dic | 2016 Effects of the neuroprotective drugs somatostatin and brimonidine on retinal cell models of diabetic retinopathy. Beltramo, E, Lopatina, T, Mazzeo, A, Arroba, AI , Valverde, AM , Hernández, C, Simó, R, Porta, M. Acta Diabetol - 53 (6) : 957-964 (PMID: 27552833) (doi:10.1007/s00592-016-0895-4)
19 oct | 2016 Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Klionsky, DJ, [ .., ], Bartolomé, A , [ .., ], Escalante, R , [ .., ], Magariños, M , [ .., ], Martín-Sanz, P , [ .., ], Sanchez-Prieto, R , [ .., ], Valverde, AM , [ .., ], Varela-Nieto, I , [ .., ], Zughaier, SM. Autophagy - 12 (1) : 1-222 (PMID: 26799652) (doi:10.1080/15548627.2015.1100356)
10 oct | 2016 p21(Cip1) plays a critical role in the physiological adaptation to fasting through activation of PPARα. Lopez-Guadamillas, E, Fernandez-Marcos, PJ, Pantoja, C, Muñoz-Martin, M, Martínez, D, Gómez-López, G, Campos-Olivas, R, Valverde, AM , Serrano, M. Sci Rep - 6 : 34542 (PMID: 27721423) (doi:10.1038/srep34542)
1 oct | 2016 Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and Is Activated by PPARβ/δ Deficiency. Zarei, M, Barroso, E, Leiva, R, Barniol-Xicota, M, Pujol, E, Escolano, C, Vázquez, S, Palomer, X, Pardo, V , González-Rodríguez, Á , Valverde, ÁM , Quesada-López, T, Villarroya, F, Wahli, W, Vázquez-Carrera, M. Diabetes - 65 (10) : 3185-3199 (PMID: 27486236) (doi:10.2337/db16-0155)
26 sep | 2016 Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes. García-Casarrubios, E , de Moura, C, Arroba, AI , Pescador, N , Calderon-Dominguez, M, Garcia, L, Herrero, L, Serra, D, Cadenas, S, Reis, F, Carvalho, E, Obregon, MJ , Valverde, ÁM . Biochim. Biophys. Acta - 1861 (12 Pt A) : 1929-1941 (PMID: 27686967) (doi:10.1016/j.bbalip.2016.09.016)
1 sep | 2016 Autophagy resolves early retinal inflammation in Igf1-deficient mice. Arroba, AI , Rodríguez-de la Rosa, L , Murillo-Cuesta, S , Vaquero-Villanueva, L, Hurlé, JM, Varela-Nieto, I , Valverde, ÁM . Dis Model Mech - 9 (9) : 965-974 (PMID: 27483352) (doi:10.1242/dmm.026344)
1 sep | 2016 Cyclooxygenase-2 expression in hepatocytes attenuates non-alcoholic steatohepatitis and liver fibrosis in mice. Motiño, O , Agra, N , Brea Contreras, R, Domínguez-Moreno, M, García-Monzón, C, Vargas-Castrillón, J, Carnovale, CE, Boscá, L , Casado, M, Mayoral, R , Valdecantos, MP , Valverde, ÁM , Francés, DE , Martín-Sanz, P . Biochim. Biophys. Acta - 1862 (9) : 1710-1723 (PMID: 27321932) (doi:10.1016/j.bbadis.2016.06.009)
1 sep | 2016 Modulation of microglia polarization dynamics during diabetic retinopathy in db/db mice. Arroba, AI , Alcalde-Estevez, E, García-Ramírez, M, Cazzoni, D, de la Villa, P, Sánchez-Fernández, EM, Mellet, CO, García Fernández, JM, Hernández, C, Simó, R, Valverde, ÁM . Biochim. Biophys. Acta - 1862 (9) : 1663-1674 (PMID: 27267343) (doi:10.1016/j.bbadis.2016.05.024)
20 jul | 2016 Carnitine Palmitoyltransferase 1 Increases Lipolysis, UCP1 Protein Expression and Mitochondrial Activity in Brown Adipocytes. Calderon-Dominguez, M, Sebastián, D, Fucho, R, Weber, M, Mir, JF, García-Casarrubios, E , Obregón, MJ , Zorzano, A, Valverde, ÁM , Serra, D, Herrero, L. PLoS ONE - 11 (7) : e0159399 (PMID: 27438137) (doi:10.1371/journal.pone.0159399)
20 jul | 2016 Inhibition of T-cell activation by CTLA4-Fc is sufficient to ameliorate proteinuric kidney disease. Herrera, M, Söderberg, M, Sabirsh, A, Valastro, B, Molne, J, Santamaría, B , Valverde, AM , Guionaud, S, Heasman, S, Bigley, A, Jermutus, L, Rondinone, C, Coghlan, M, Baker, D, Moreno Quinn, C. Am. J. Physiol. Renal Physiol. (PMID: 27440778) (doi:10.1152/ajprenal.00179.2016)
1 mayo | 2016 Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model. Baquedano, E, Burgos-Ramos, E, Canelles, S, González-Rodríguez, A , Chowen, JA, Argente, J, Barrios, V, Valverde, AM , Frago, LM . Dis Model Mech - 9 (5) : 573-583 (PMID: 27013528) (doi:10.1242/dmm.023515)
4 mar | 2016 Single administration of recombinant IL-6 restores the gene expression of lipogenic enzymes in liver of fasting IL-6-deficient mice. Gavito, AL, Cabello, R, Suarez, J, Serrano, A, Pavón, FJ, Vida, M, Romero, M, Pardo, V , Bautista, D, Arrabal, S, Decara, J, Cuesta, AL, Valverde, AM , Rodríguez de Fonseca, F, Baixeras, E. Br. J. Pharmacol. - 173 (6) : 1070-1084 (PMID: 26750868) (doi:10.1111/bph.13423)
1 feb | 2016 Dissecting the role of epidermal growth factor receptor catalytic activity during liver regeneration and hepatocarcinogenesis. López-Luque, J, Caballero-Díaz, D, Martinez-Palacián, A, Roncero, C, Moreno-Càceres, J, García-Bravo, M, Grueso, E, Fernández, A, Crosas-Molist, E, García-Álvaro, M, Addante, A, Bertran, E, Valverde, AM , González-Rodríguez, Á , Herrera, B, Montoliu, L, Serrano, T, Segovia, JC, Fernández, M , Ramos, E, Sánchez, A, Fabregat, I. Hepatology - 63 (2) : 604-619 (PMID: 26313466) (doi:10.1002/hep.28134)
5 ene | 2016 Down-regulation of oxidative phosphorylation in the liver by expression of the ATPase inhibitory factor 1 induces a tumor-promoter metabolic state. Santacatterina, F, Sánchez-Cenizo, L, Formentini, L, Mobasher, MA, Casas, E, Rueda, CB, Martínez-Reyes, I, Núñez de Arenas, C, García-Bermúdez, J, Zapata, JM , Sánchez-Aragó, M, Satrústegui, J, Valverde, ÁM , Cuezva, JM. Oncotarget - 7 (1) : 490-508 (PMID: 26595676) (doi:10.18632/oncotarget.6357)
1 ene | 2016 Topical Administration of GLP-1 Receptor Agonists Prevents Retinal Neurodegeneration in Experimental Diabetes. Hernández, C, Bogdanov, P, Corraliza, L, García-Ramírez, M, Solà-Adell, C, Arranz, JA, Arroba, AI , Valverde, AM , Simó, R. Diabetes - 65 (1) : 172-187 (PMID: 26384381) (doi:10.2337/db15-0443)
31 dic | 2015 IRS2 and PTEN are key molecules in controlling insulin sensitivity in podocytes. Santamaria, B , Marquez, E, Lay, A, Carew, RM, González-Rodríguez, Á , Welsh, GI, Ni, L, Hale, LJ, Ortiz, A, Saleem, MA, Brazil, DP, Coward, RJ, Valverde, ÁM . Biochim. Biophys. Acta - 1853 (12) : 3224-3234 (PMID: 26384875) (doi:10.1016/j.bbamcr.2015.09.020)
1 dic | 2015 Inhibition of Protein Tyrosine Phosphatase 1B Improves IGF-I Receptor Signaling and Protects Against Inflammation-Induced Gliosis in the Retina. Arroba, AI , Valverde, ÁM . Invest. Ophthalmol. Vis. Sci. - 56 (13) : 8031-8044 (PMID: 26720454) (doi:10.1167/iovs.15-17234)
1 dic | 2015 Response to Comment on Francés et al. Hepatic Cyclooxygenase-2 Expression Protects Against Diet-Induced Steatosis, Obesity, and Insulin Resistance. Diabetes 2015;64:1522-1531. Valverde, ÁM , Martín-Sanz, P . Diabetes - 64 (12) : e43-4 (PMID: 26604179) (doi:10.2337/dbi15-0023)
21 oct | 2015 RNA Interference as a Therapeutic Strategy for the Treatment of Liver Diseases. Gonzalez-Rodriguez, A , Valverde, AM . Curr. Pharm. Des. - 21 (31) : 4574-4586 (PMID: 26486144)
4 ago | 2015 Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1-independent manner. González-Rodríguez, Á , Santamaría, B , Mas-Gutierrez, JA, Rada, P , Fernández-Millán, E, Pardo, V , Álvarez, C, Cuadrado, A , Ros, M, Serrano, M, Valverde, ÁM . Mol Nutr Food Res - 59 (8) : 1431-1442 (PMID: 25808216) (doi:10.1002/mnfr.201400933)
1 jul | 2015 Essential role of Nrf2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes. Valdecantos, MP , Prieto-Hontoria, PL, Pardo, V , Módol, T, Santamaría, B , Weber, M, Herrero, L, Serra, D, Muntané, J, Cuadrado, A , Moreno-Aliaga, MJ, Alfredo Martínez, J, Valverde, ÁM . Free Radic. Biol. Med. - 84 : 263-278 (PMID: 25841776) (doi:10.1016/j.freeradbiomed.2015.03.019)
1 mayo | 2015 Hepatic cyclooxygenase-2 expression protects against diet-induced steatosis, obesity, and insulin resistance. Francés, DE , Motiño, O , Agrá, N, González-Rodríguez, Á , Fernández-Álvarez, A, Cucarella, C, Mayoral, R , Castro-Sánchez, L, García-Casarrubios, E , Boscá, L , Carnovale, CE, Casado, M, Valverde, ÁM , Martín-Sanz, P . Diabetes - 64 (5) : 1522-1531 (PMID: 25422106) (doi:10.2337/db14-0979)
3 abr | 2015 Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, lipotoxicity, insulin resistance and in oleic acid-induced protection. Pardo, V , González-Rodríguez, Á , Muntané, J, Kozma, SC, Valverde, ÁM . Food Chem. Toxicol. (PMID: 25846498) (doi:10.1016/j.fct.2015.03.029)
19 mar | 2015 Opposite Cross-Talk by Oleate and Palmitate on Insulin Signaling in Hepatocytes through Macrophage Activation. Pardo, V , Gonzalez-Rodriguez, A , Guijas, C, Balsinde, J, Valverde, AM . J. Biol. Chem. (PMID: 25792746) (doi:10.1074/jbc.M115.649483)
1 mar | 2015 WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes. Rada, P , Rojo, AI , Offergeld, A, Feng, GJ, Velasco-Martín, JP, González-Sancho, JM , Valverde, ÁM , Dale, T, Regadera, J, Cuadrado, A . Antioxid. Redox Signal. - 22 (7) : 555-571 (PMID: 25336178) (doi:10.1089/ars.2014.6040)
16 feb | 2015 SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function. Boutant, M, Joffraud, M, Kulkarni, SS, García-Casarrubios, E , García-Roves, PM, Ratajczak, J, Fernández-Marcos, PJ, Valverde, AM , Serrano, M, Cantó, C. Mol Metab - 4 (2) : 118-131 (PMID: 25685699) (doi:10.1016/j.molmet.2014.12.008)
17 oct | 2014 Essential role of protein-tyrosine phosphatase 1B in the modulation of insulin signaling by acetaminophen in hepatocytes. Mobasher, MA, de Toro-Martín, J, González-Rodríguez, Á , Ramos, S, Letzig, LG, James, LP, Muntané, J, Álvarez, C, Valverde, ÁM . J. Biol. Chem. - 289 (42) : 29406-29419 (PMID: 25204659) (doi:10.1074/jbc.M113.539189)
1 sep | 2014 In vivo siRNA delivery of Keap1 modulates death and survival signaling pathways and attenuates concanavalin-A-induced acute liver injury in mice. González-Rodríguez, Á , Reibert, B, Amann, T, Constien, R, Rondinone, CM, Valverde, ÁM . Dis Model Mech - 7 (9) : 1093-1100 (PMID: 24997191) (doi:10.1242/dmm.015537)
1 mayo | 2014 Signalling pathways involved in paracetamol-induced hepatotoxicity: new insights on the role of protein tyrosine phosphatase 1B. Mobasher, MA, Valverde, ÁM . Arch. Physiol. Biochem. - 120 (2) : 51-63 (PMID: 24738658) (doi:10.3109/13813455.2014.893365)
13 mar | 2014 Pivotal role of protein tyrosine phosphatase 1B (PTP1B) in the macrophage response to pro-inflammatory and anti-inflammatory challenge. Través, PG , Pardo, V , Pimentel-Santillana, M, González-Rodríguez, Á, Mojena, M , Rico, D, Montenegro, Y, Calés, C , Martín-Sanz, P , Valverde, AM , Boscá, L . Cell Death Dis - 5 : e1125 (PMID: 24625984) (doi:10.1038/cddis.2014.90)
19 jun | 2013 Loss of protein tyrosine phosphatase 1B increases IGF-I receptor tyrosine phosphorylation but does not rescue retinal defects in IRS2-deficient mice. Arroba, AI , Revuelta-Cervantes, J , Menes, L, González-Rodríguez, Á , Pardo, V , de la Villa, P, Burks, DJ, Valverde, ÁM . Invest. Ophthalmol. Vis. Sci. - 54 (6) : 4215-4225 (PMID: 23702782) (doi:10.1167/iovs.12-11438)
24 mayo | 2013 Sterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2. Sanz-Garcia, C, Ferrer-Mayorga, G , González-Rodríguez, Á , Valverde, AM , Martín-Duce, A, Velasco-Martín, JP, Regadera, J, Fernández, M , Alemany, S . J. Biol. Chem. - 288 (21) : 15342-15351 (PMID: 23572518) (doi:10.1074/jbc.M112.439547)
9 mayo | 2013 Protein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity. Mobasher, MA, González-Rodriguez, A, Santamaría, B, Ramos, S, Martín, MÁ, Goya, L, Rada, P, Letzig, L, James, LP, Cuadrado, A , Martín-Pérez, J , Simpson, KJ, Muntané, J, Valverde, AM . Cell Death Dis - 4 : e626 (PMID: 23661004) (doi:10.1038/cddis.2013.150)
1 mar | 2013 Cyclooxygenase-2 over-expression inhibits liver apoptosis induced by hyperglycemia. Francés, DE, Ingaramo, PI , Mayoral, R , Través, P, Casado, M, Valverde, ÁM , Martín-Sanz, P , Carnovale, CE. J. Cell. Biochem. - 114 (3) : 669-680 (PMID: 23059845) (doi:10.1002/jcb.24409)
7 ene | 2013 Proapoptotic and survival signaling in the neuroretina at early stages of diabetic retinopathy. Valverde, AM , Miranda, S , García-Ramírez, M, González-Rodriguez, Á , Hernández, C, Simó, R. Mol. Vis. - 19 : 47-53 (PMID: 23335850)
1 dic | 2012 Studies of naturally occurring friedelane triterpenoids as insulin sensitizers in the treatment type 2 diabetes mellitus. Ardiles, AE, González-Rodríguez, A , Núñez, MJ, Perestelo, NR, Pardo, V , Jiménez, IA, Valverde, AM , Bazzocchi, IL. Phytochemistry - 84 : 116-124 (PMID: 22925829) (doi:10.1016/j.phytochem.2012.07.025)
1 jun | 2012 Beneficial effects of fenofibrate in retinal pigment epithelium by the modulation of stress and survival signaling under diabetic conditions. Miranda, S , González-Rodríguez, Á , García-Ramírez, M, Revuelta-Cervantes, J , Hernández, C, Simó, R, Valverde, ÁM . J. Cell. Physiol. - 227 (6) : 2352-2362 (PMID: 21826649) (doi:10.1002/jcp.22970)
1 jun | 2012 Protein-tyrosine phosphatases are involved in interferon resistance associated with insulin resistance in HepG2 cells and obese mice. García-Ruiz, I , Solís-Muñoz, P, Gómez-Izquierdo, E, Muñoz-Yagüe, MT, Valverde, AM , Solís-Herruzo, JA. J. Biol. Chem. - 287 (23) : 19564-19573 (PMID: 22493491) (doi:10.1074/jbc.M112.342709)
4 mayo | 2012 Protein-tyrosine phosphatase 1B (PTP1B) deficiency confers resistance to transforming growth factor-β (TGF-β)-induced suppressor effects in hepatocytes. Ortiz, C, Caja, L, Bertran, E, Gonzalez-Rodriguez, Á , Valverde, ÁM , Fabregat, I, Sancho, P. J. Biol. Chem. - 287 (19) : 15263-15274 (PMID: 22427664) (doi:10.1074/jbc.M111.303958)
1 abr | 2012 Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging. González-Rodríguez, A , Más-Gutierrez, JA, Mirasierra, M , Fernandez-Pérez, A , Lee, YJ, Ko, HJ, Kim, JK, Romanos, E, Carrascosa, JM, Ros, M, Vallejo, M , Rondinone, CM, Valverde, AM . Aging Cell - 11 (2) : 284-296 (PMID: 22221695) (doi:10.1111/j.1474-9726.2011.00786.x)
30 mar | 2012 Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function. Murillo-Cuesta, S , Camarero, G , González-Rodríguez, A , De La Rosa, LR , Burks, DJ, Avendaño, C, Valverde, AM , Varela-Nieto, I . Mol. Med. - 18 : 260-269 (PMID: 22160220) (doi:10.2119/molmed.2011.00328)
7 mar | 2012 Pten positively regulates brown adipose function, energy expenditure, and longevity. Ortega-Molina, A, Efeyan, A, Lopez-Guadamillas, E, Muñoz-Martin, M, Gómez-López, G, Cañamero, M, Mulero, F, Pastor, J, Martinez, S, Romanos, E, Mar Gonzalez-Barroso, M, Rial, E, Valverde, AM , Bischoff, JR, Serrano, M. Cell Metab. - 15 (3) : 382-394 (PMID: 22405073) (doi:10.1016/j.cmet.2012.02.001)
1 mar | 2012 Differential insulin receptor substrate-1 (IRS1)-related modulation of neuropeptide Y and proopiomelanocortin expression in nondiabetic and diabetic IRS2-/- mice. Burgos-Ramos, E, González-Rodríguez, A , Canelles, S, Baquedano, E, Frago, LM , Revuelta-Cervantes, J , Gómez-Ambrosi, J, Frühbeck, G, Chowen, JA, Argente, J, Valverde, AM , Barrios, V. Endocrinology - 153 (3) : 1129-1140 (PMID: 22210743) (doi:10.1210/en.2011-1278)
1 jul | 2011 IRS2 and PTP1B: Two opposite modulators of hepatic insulin signalling. Valverde, AM , González-Rodríguez, A . Arch. Physiol. Biochem. - 117 (3) : 105-115 (PMID: 21401320) (doi:10.3109/13813455.2011.557386)
1 abr | 2011 Protein Tyrosine Phosphatase 1B (PTP1B) deficiency accelerates hepatic regeneration in mice. Revuelta-Cervantes, J , Mayoral, R , Miranda, S , González-Rodríguez, A , Fernández, M , Martín-Sanz, P , Valverde, AM . Am. J. Pathol. - 178 (4) : 1591-1604 (PMID: 21406170) (doi:10.1016/j.ajpath.2010.12.020)
1 ene | 2011 Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C. García-Monzón, C, Lo Iacono, O, Mayoral, R , González-Rodríguez, A , Miquilena-Colina, ME, Lozano-Rodríguez, T, García-Pozo, L, Vargas-Castrillón, J, Casado, M, Boscá, L , Valverde, AM , Martín-Sanz, P . J. Hepatol. - 54 (1) : 142-152 (PMID: 20888662) (doi:10.1016/j.jhep.2010.06.021)
1 oct | 2010 PTP1B deficiency enhances liver growth during suckling by increasing the expression of insulin-like growth factor-I. Escrivá, F, González-Rodriguez, A , Fernández-Millán, E, Rondinone, CM, Alvarez, C, Valverde, AM . J. Cell. Physiol. - 225 (1) : 214-222 (PMID: 20506299) (doi:10.1002/jcp.22246)
1 abr | 2010 Beneficial effects of PTP1B deficiency on brown adipocyte differentiation and protection against apoptosis induced by pro- and anti-inflammatory stimuli. Miranda, S , González-Rodríguez, A , Revuelta-Cervantes, J , Rondinone, CM, Valverde, AM . Cell. Signal. - 22 (4) : 645-659 (PMID: 20026400) (doi:10.1016/j.cellsig.2009.11.019)
30 mar | 2010 Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice. González-Rodríguez, A , Mas Gutierrez, JA, Sanz-González, S, Ros, M, Burks, DJ, Valverde, AM . Diabetes - 59 (3) : 588-599 (PMID: 20028942) (doi:10.2337/db09-0796)
5 feb | 2010 Impairment of transforming growth factor beta signaling in caveolin-1-deficient hepatocytes: role in liver regeneration. Mayoral, R , Valverde, AM , Llorente Izquierdo, C , González-Rodríguez, A , Boscá, L , Martín-Sanz, P . J. Biol. Chem. - 285 (6) : 3633-3642 (PMID: 19966340) (doi:10.1074/jbc.M109.072900)
18 ene | 2010 Normal proliferation and tumorigenesis but impaired pancreatic function in mice lacking the cell cycle regulator sei1. Fernandez-Marcos, PJ, Pantoja, C, Gonzalez-Rodriguez, A , Martin, N, Flores, JM, Valverde, AM , Hara, E, Serrano, M. PLoS ONE - 5 (1) : e8744 (PMID: 20090907) (doi:10.1371/journal.pone.0008744)
28 jul | 2009 S6K1 deficiency protects against apoptosis in hepatocytes. González-Rodriguez, A , Alba, J, Zimmerman, V, Kozma, SC, Valverde, AM . Hepatology - 50 (1) : 216-229 (PMID: 19437488) (doi:10.1002/hep.22915)
8 ago | 2008 PTP1B deficiency increases glucose uptake in neonatal hepatocytes: involvement of IRA/GLUT2 complexes. González-Rodriguez, A , Nevado, C, Escrivá, F, Sesti, G, Rondinone, CM, Benito, M, Valverde, AM . Am. J. Physiol. Gastrointest. Liver Physiol. - 295 (2) : G338-47 (PMID: 18535291) (doi:10.1152/ajpgi.00514.2007)
1 mar | 2008 Role of insulin receptor and balance in insulin receptor isoforms A and B in regulation of apoptosis in simian virus 40-immortalized neonatal hepatocytes. Nevado, C, Benito, M, Valverde, AM . Mol. Biol. Cell - 19 (3) : 1185-1198 (PMID: 18172021) (doi:10.1091/mbc.E07-05-0473)
27 jul | 2007 Levels of protein tyrosine phosphatase 1B determine susceptibility to apoptosis in serum-deprived hepatocytes. González-Rodriguez, A , Escribano, O, Alba, J, Rondinone, CM, Benito, M, Valverde, AM . J. Cell. Physiol. - 212 (1) : 76-88 (PMID: 17323378) (doi:10.1002/jcp.21004)
1 mayo | 2007 Nuclear forkhead box O1 controls and integrates key signaling pathways in hepatocytes. Naïmi, M, Gautier, N, Chaussade, C, Valverde, AM , Accili, D, Van Obberghen, E. Endocrinology - 148 (5) : 2424-2434 (PMID: 17303659) (doi:10.1210/en.2006-1411)
30 mar | 2007 IRS-3 mediates insulin-induced glucose uptake in differentiated IRS-2(-/-) brown adipocytes. Escribano, O, Arribas, M, Valverde, AM , Benito, M. Mol. Cell. Endocrinol. - 268 (1-2) : 1-9 (PMID: 17316975) (doi:10.1016/j.mce.2006.12.039)
27 feb | 2007 Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes. Gonzalez-Rodriguez, A , Clampit, JE, Escribano, O, Benito, M, Rondinone, CM, Valverde, AM . Endocrinology - 148 (2) : 594-608 (PMID: 17068137) (doi:10.1210/en.2006-0644)
1 feb | 2007 Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-alpha-induced insulin resistance. Nieto-Vazquez, I, Fernández-Veledo, S, de Alvaro, C, Rondinone, CM, Valverde, AM , Lorenzo, M. Diabetes - 56 (2) : 404-413 (PMID: 17259385) (doi:10.2337/db06-0989)