1 Jul | 2012 Acid ceramidase as a chemotherapeutic target to overcome resistance to the antitumoral effect of choline kinase α inhibition. Ramírez de Molina, A, de la Cueva, A, Machado-Pinilla, R , Rodriguez-Fanjul, V , Gomez del Pulgar, T, Cebrian, A, Perona, R , Lacal, JC . Curr Cancer Drug Targets - 12 (6) : 617-624 (PMID: 22515519)
1 May | 2012 Sensitization of (colon) cancer cells to death receptor related therapies: a report from the FP6-ONCODEATH research consortium. Pintzas, A, Zhivotovsky, B, Workman, P, Clarke, PA, Linardopoulos, S, Martinou, JC, Lacal, JC , Robine, S, Nasioulas, G, Andera, L. Cancer Biol. Ther. - 13 (7) : 458-466 (PMID: 22406997) (doi:10.4161/cbt.19600)
1 Sep | 2011 Approaches for the study of cancer: towards the integration of genomics, proteomics and metabolomics. Casado-Vela, J , Cebrián, A , Gómez del Pulgar, MT, Lacal, JC . Clin Transl Oncol - 13 (9) : 617-628 (PMID: 21865133) (doi:10.1007/s12094-011-0707-9)
17 Jun | 2011 Human urine proteomics: building a list of human urine cancer biomarkers. Casado-Vela, J , Gómez del Pulgar, T , Cebrián, A , Alvarez-Ayerza, N , Lacal, JC . Expert Rev Proteomics - 8 (3) : 347-360 (PMID: 21679116) (doi:10.1586/epr.11.26)
3 Feb | 2011 Lights and shadows of proteomic technologies for the study of protein species including isoforms, splicing variants and protein post-translational modifications. Casado-Vela, J , Casado-Vela, J , Cebrián, A , Cebrián, A , Gómez del Pulgar, MT, Gómez del Pulgar, MT, Sánchez-López, E , Sánchez-López, E , Vilaseca, M, Vilaseca, M, Menchén, L , Menchén, L , Diema, C, Diema, C, Sellés-Marchart, S, Sellés-Marchart, S, Martínez-Esteso, MJ, Martínez-Esteso, MJ, Yubero, N , Yubero, N , Bru-Martínez, R, Bru-Martínez, R, Lacal, JC , Lacal, JC , Lacal, JC , Lacal, JC . Proteomics - 11 (4) : 590-603 (PMID: 21229583) (doi:10.1002/pmic.201000287)
12 Nov | 2009 Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment. Gallego-Ortega, D , Ramirez de Molina, A , Ramos, MA , Valdes-Mora, F , Barderas, MG, Sarmentero-Estrada, J , Lacal, JC . PLoS ONE - 4 (11) : e7819 (PMID: 19915674) (doi:10.1371/journal.pone.0007819)
16 Dec | 2008 Choline kinase alpha depletion selectively kills tumoral cells. Bañez-Coronel, M , Ramírez de Molina, A , Rodríguez-González, A , Sarmentero, J , Ramos, MA , García-Cabezas, MA , García-Oroz, L , Lacal, JC . Curr Cancer Drug Targets - 8 (8) : 709-719 (PMID: 19075594)
1 Aug | 2006 Generation and characterization of monoclonal antibodies against choline kinase alpha and their potential use as diagnostic tools in cancer. Gallego-Ortega, D , Ramirez De Molina, A , Gutierrez, R , Ramos, MA , Sarmentero, J , Cejas, P , Nistal, M, González Barón, M, Lacal, JC . Int. J. Oncol. - 29 (2) : 335-340 (PMID: 16820874)
1 Mar | 2006 18F-choline images murine atherosclerotic plaques ex vivo. Matter, CM, Wyss, MT, Meier, P, Späth, N, von Lukowicz, T, Lohmann, C, Weber, B, Ramirez de Molina, A , Lacal, JC , Ametamey, SM, von Schulthess, GK, Lüscher, TF, Kaufmann, PA, Buck, A. Arterioscler. Thromb. Vasc. Biol. - 26 (3) : 584-589 (PMID: 16357314) (doi:10.1161/01.ATV.0000200106.34016.18)
1 Jan | 2006 Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models. Al-Saffar, NM, Troy, H, Ramírez de Molina, A , Jackson, LE, Madhu, B, Griffiths, JR, Leach, MO, Workman, P, Lacal, JC , Judson, IR, Chung, YL. Cancer Res - 66 (1) : 427-434 (PMID: 16397258) (doi:10.1158/0008-5472.CAN-05-1338)
1 Jun | 2005 Rho GTPase expression in tumourigenesis: evidence for a significant link. Gómez del Pulgar, T , Benitah, SA, Valerón, PF, Espina, C , Lacal, JC . Bioessays - 27 (6) : 602-613 (PMID: 15892119) (doi:10.1002/bies.20238)
17 Dec | 2004 Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation. Benitah, SA, Valerón, PF, van Aelst, L, Marshall, CJ, Lacal, JC . Biochim. Biophys. Acta - 1705 (2) : 121-132 (PMID: 15588766) (doi:10.1016/j.bbcan.2004.10.002)
28 Oct | 2004 Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action. Rodríguez-González, A , Ramirez de Molina, A , Fernández, F, Lacal, JC . Oncogene - 23 (50) : 8247-8259 (PMID: 15378008) (doi:10.1038/sj.onc.1208045)
21 Oct | 2004 Influence of the linker in bispyridium compounds on the inhibition of human choline kinase. Conejo-García, A, Báñez-Coronel, M, Sánchez-Martín, RM, Rodríguez-González, A , Ramos, A, Ramírez de Molina, A , Espinosa, A, Gallo, MA, Campos, JM, Lacal, JC . J. Med. Chem. - 47 (22) : 5433-5440 (PMID: 15481981) (doi:10.1021/jm0496537)
15 Sep | 2004 Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression. Ramírez de Molina, A , Báñez-Coronel, M, Gutiérrez, R , Rodríguez-González, A , Olmeda, D , Megías, D, Lacal, JC . Cancer Res. - 64 (18) : 6732-6739 (PMID: 15374991) (doi:10.1158/0008-5472.CAN-04-0489)
8 Apr | 2004 From Ras signalling to ChoK inhibitors: a further advance in anticancer drug design. Ramírez de Molina, A , Rodríguez-González, A , Lacal, JC . Cancer Lett. - 206 (2) : 137-148 (PMID: 15013519) (doi:10.1016/j.canlet.2003.08.031)
8 Apr | 2004 Rho GTPases: potential candidates for anticancer therapy. Aznar, S, Fernández-Valerón, P, Espina, C , Lacal, JC . Cancer Lett. - 206 (2) : 181-191 (PMID: 15013523) (doi:10.1016/j.canlet.2003.08.035)
4 Dec | 2003 Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells. Rodríguez-González, A , Ramírez de Molina, A , Fernández, F, Ramos, MA , del Carmen Núñez, M, Campos, J, Lacal, JC . Oncogene - 22 (55) : 8803-8812 (PMID: 14654777) (doi:10.1038/sj.onc.1207062)
14 Jul | 2003 ROCK and nuclear factor-kappaB-dependent activation of cyclooxygenase-2 by Rho GTPases: effects on tumor growth and therapeutic consequences. Benitah, SA, Valerón, PF, Lacal, JC . Mol. Biol. Cell - 14 (7) : 3041-3054 (PMID: 12857884) (doi:10.1091/mbc.E03-01-0016)
16 Jan | 2003 STAT5a activation mediates the epithelial to mesenchymal transition induced by oncogenic RhoA. Benitah, SA, Valerón, PF, Rui, H, Lacal, JC . Mol. Biol. Cell - 14 (1) : 40-53 (PMID: 12529425) (doi:10.1091/mbc.E02-08-0454)
1 Jan | 2003 Choline kinase inhibitory effect and antiproliferative activity of new 1,1',1"-(benzene-1,3,5-triylmethylene)tris[4-[(disubstituted)amino]pyridinium] tribromides. Conejo-García, A, Campos, J, Sánchez, RM, Rodríguez-González, A , Lacal, JC , Gallo, MA, Espinosa, A. Eur J Med Chem - 38 (1) : 109-116 (PMID: 12593921)
1 Sep | 2002 Modulation of phospholipase D by Ras proteins mediated by its effectors Ral-GDS, PI3K and Raf-1. Lucas, L , Penalva, V , Ramírez de Molina, A , Del Peso, L , Lacal, JC . Int. J. Oncol. - 21 (3) : 477-485 (PMID: 12168089)
15 Aug | 2002 Cell stress and MEKK1-mediated c-Jun activation modulate NFkappaB activity and cell viability. Sánchez-Pérez, I , Benitah, SA, Martínez-Gomariz, M, Lacal, JC , Perona, R . Mol. Biol. Cell - 13 (8) : 2933-2945 (PMID: 12181357) (doi:10.1091/mbc.E02-01-0022)
1 Jul | 2002 Quantitative structure-activity relationships for a series of symmetrical bisquaternary anticancer compounds. Campos, JM, Núñez, MC, Sánchez, RM, Gómez-Vidal, JA, Rodríguez-González, A , Báñez, M, Gallo, MA, Lacal, JC , Espinosa, A. Bioorg. Med. Chem. - 10 (7) : 2215-2231 (PMID: 11983519)
20 Jun | 2002 Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy. Ramírez de Molina, A , Gutiérrez, R , Ramos, MA , Silva, JM, Silva, J, Bonilla, F, Sánchez, JJ, Lacal, JC . Oncogene - 21 (27) : 4317-4322 (PMID: 12082619) (doi:10.1038/sj.onc.1205556)
31 Jan | 2002 Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K. Ramírez de Molina, A , Penalva, V , Lucas, L , Lacal, JC . Oncogene - 21 (6) : 937-946 (PMID: 11840339) (doi:10.1038/sj.onc.1205144)
12 Oct | 2001 Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation. Aznar, S , Valerón, PF, del Rincon, SV, Pérez, LF, Perona, R , Lacal, JC . Mol. Biol. Cell - 12 (10) : 3282-3294 (PMID: 11598209)
27 Jul | 2001 Inhibition of ChoK is an efficient antitumor strategy for Harvey-, Kirsten-, and N-ras-transformed cells. Ramírez de Molina, A, Rodríguez-González, A, Penalva, V , Lucas, L , Lacal, JC . Biochem. Biophys. Res. Commun. - 285 (4) : 873-879 (PMID: 11467831) (doi:10.1006/bbrc.2001.5250)
10 Apr | 2001 Rho signals to cell growth and apoptosis. Aznar, S , Lacal, JC . Cancer Lett. - 165 (1) : 1-10 (PMID: 11248412)
1 Mar | 2001 LUMO energy of model compounds of bispyridinium compounds as an index for the inhibition of choline kinase. Campos, J, del Carmen Núñez, M, Rodríguez, V, Entrena, A, Hernández-Alcoceba, R , Fernández, F, Lacal, JC , Gallo, MA, Espinosa, A. Eur J Med Chem - 36 (3) : 215-225 (PMID: 11337100)
1 Mar | 2001 Modulation of phospholipase D by hexadecylphosphorylcholine: a putative novel mechanism for its antitumoral activity. Lucas, L , Hernández-Alcoceba, R , Penalva, V , Lacal, JC . Oncogene - 20 (9) : 1110-1117 (PMID: 11314048) (doi:10.1038/sj.onc.1204216)
21 Dec | 2000 Apoptosis induced by Rac GTPase correlates with induction of FasL and ceramides production. Embade, N , Valerón, PF, Aznar, S , López-Collazo, E, Lacal, JC . Mol. Biol. Cell - 11 (12) : 4347-4358 (PMID: 11102528)
20 Jan | 2000 Ras protein is involved in the physiological regulation of phospholipase D by platelet derived growth factor. Lucas, L , del Peso, L , Rodríguez, P, Penalva, V , Lacal, JC . Oncogene - 19 (3) : 431-437 (PMID: 10656691) (doi:10.1038/sj.onc.1203323)
1 Jul | 1999 In vivo antitumor activity of choline kinase inhibitors: a novel target for anticancer drug discovery. Hernández-Alcoceba, R , Fernández, F, Lacal, JC . Cancer Res. - 59 (13) : 3112-3118 (PMID: 10397253)
26 Mar | 1999 Activation of serum response factor by RhoA is mediated by the nuclear factor-kappaB and C/EBP transcription factors. Montaner, S , Perona, R , Saniger, L, Lacal, JC . J. Biol. Chem. - 274 (13) : 8506-8515 (PMID: 10085083)
8 Oct | 1998 Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway. Esteve, P , Embade, N , Perona, R , Jiménez, B , del Peso, L , León, J, Arends, M, Miki, T, Lacal, JC . Oncogene - 17 (14) : 1855-1869 (PMID: 9778052) (doi:10.1038/sj.onc.1202082)
22 May | 1998 Multiple signalling pathways lead to the activation of the nuclear factor kappaB by the Rho family of GTPases. Montaner, S , Perona, R , Saniger, L, Lacal, JC . J. Biol. Chem. - 273 (21) : 12779-12785 (PMID: 9582304)
30 Jan | 1998 Wortmannin, an inhibitor of phosphatidyl-inositol 3-kinase, induces oocyte maturation through a MPF-MAPK-dependent pathway. Carnero, A, Lacal, JC . FEBS Lett. - 422 (2) : 155-159 (PMID: 9489996)
18 Dec | 1997 Rho proteins induce metastatic properties in vivo. del Peso, L , Hernández-Alcoceba, R , Embade, N , Carnero, A, Esteve, P , Paje, C, Lacal, JC . Oncogene - 15 (25) : 3047-3057 (PMID: 9444953) (doi:10.1038/sj.onc.1201499)
8 Dec | 1997 Micro-injection of recombinant lysyl oxidase blocks oncogenic p21-Ha-Ras and progesterone effects on Xenopus laevis oocyte maturation. Di Donato, A, Lacal, JC , Di Duca, M, Giampuzzi, M, Ghiggeri, G, Gusmano, R. FEBS Lett. - 419 (1) : 63-68 (PMID: 9426221)
6 Nov | 1997 Choline kinase inhibitors as a novel approach for antiproliferative drug design. Hernández-Alcoceba, R , Saniger, L, Campos, J, Núñez, MC, Khaless, F, Gallo, MA, Espinosa, A, Lacal, JC . Oncogene - 15 (19) : 2289-2301 (PMID: 9393874) (doi:10.1038/sj.onc.1201414)
15 Aug | 1997 Signaling from G protein-coupled receptors to the c-jun promoter involves the MEF2 transcription factor. Evidence for a novel c-jun amino-terminal kinase-independent pathway. Coso, OA, Montaner, S , Fromm, C, Lacal, JC , Prywes, R, Teramoto, H, Gutkind, JS. J. Biol. Chem. - 272 (33) : 20691-20697 (PMID: 9252389)
23 Jun | 1997 Regulation of proliferation and apoptosis by Ras and Rho GTPases through specific phospholipid-dependent signaling. Lacal, JC . FEBS Lett. - 410 (1) : 73-77 (PMID: 9247126)
1 Mar | 1997 Activation of phospholipase D by growth factors and oncogenes in murine fibroblasts follow alternative but cross-talking pathways. del Peso, L , Lucas, L , Esteve, P , Lacal, JC . Biochem. J. - 322 ( Pt 2) : 519-528 (PMID: 9065772)
15 Feb | 1997 Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins. Perona, R , Montaner, S , Saniger, L, Sánchez-Pérez, I , Bravo, R, Lacal, JC . Genes Dev. - 11 (4) : 463-475 (PMID: 9042860)
15 Jun | 1996 Activation of phospholipase D by ras proteins is independent of protein kinase C. del Peso, L , Hernández, R, Esteve, P , Lacal, JC . J. Cell. Biochem. - 61 (4) : 599-608 (PMID: 8806084) (doi:10.1002/(SICI)1097-4644(19960616)61:4<599::AID-JCB14>3.0.CO;2-B)
21 Dec | 1995 Induction of apoptosis by rho in NIH 3T3 cells requires two complementary signals. Ceramides function as a progression factor for apoptosis. Esteve, P , del Peso, L , Lacal, JC . Oncogene - 11 (12) : 2657-2665 (PMID: 8545123)
16 Feb | 1995 Activation of intracellular kinases in Xenopus oocytes by p21ras and phospholipases: a comparative study. Carnero, A, Lacal, JC . Mol. Cell. Biol. - 15 (2) : 1094-1101 (PMID: 7823925)
1 Jan | 1995 Generation of phosphorylcholine as an essential event in the activation of Raf-1 and MAP-kinases in growth factors-induced mitogenic stimulation. Jiménez, B , del Peso, L , Montaner, S , Esteve, P , Lacal, JC . J. Cell. Biochem. - 57 (1) : 141-149 (PMID: 7721953) (doi:10.1002/jcb.240570114)
1 Aug | 1994 Progesterone but not ras requires MPF for in vivo activation of MAPK and S6 KII: MAPK is an essential conexion point of both signaling pathways. Carnero, A, Jiménez, B , Lacal, JC . J. Cell. Biochem. - 55 (4) : 465-476 (PMID: 7962177) (doi:10.1002/jcb.240550406)
10 May | 1994 Activation of type D phospholipase by serum stimulation and ras-induced transformation in NIH3T3 cells. Carnero, A, Cuadrado, A , del Peso, L , Lacal, JC . Oncogene - 9 (5) : 1387-1395 (PMID: 8152799)
24 Nov | 1993 Phosphorylcholine: a novel second messenger essential for mitogenic activity of growth factors. Cuadrado, A , Carnero, A, Dolfi, F, Jiménez, B , Lacal, JC . Oncogene - 8 (11) : 2959-2968 (PMID: 8414498)
2 Aug | 1993 Acylphosphatase synergizes with progesterone during maturation of Xenopus laevis oocytes. Dolfi, F, Carnero, A, Cuadrado, A , Ramponi, G, Lacal, JC . FEBS Lett. - 327 (3) : 265-270 (PMID: 8394242)
12 Jul | 1993 Localization of rap1 and rap2 proteins in the gelatinase-containing granules of human neutrophils. Mollinedo, F, Perez-Sala, D, Gajate, C, Jimenez, B , Rodriguez, P, Lacal, JC . FEBS Lett. - 326 (1-3) : 209-214 (PMID: 8391995)
12 Jul | 1993 Microinjection of acylphosphatase blocks Xenopus laevis oocytes maturation induced by ras-p21. Dolfi, F, Carnero, A, Ramponi, G, Lacal, JC . FEBS Lett. - 326 (1-3) : 167-170 (PMID: 8391991)
24 May | 1993 Tumorigenic activity of rho genes from Aplysia californica. Perona, R , Esteve, P , Jiménez, B , Ballestero, RP, Ramón y Cajal, S, Lacal, JC . Oncogene - 8 (5) : 1285-1292 (PMID: 8479750)
25 Jun | 1990 Regulation of protein kinase C activity in neuronal differentiation induced by the N-ras oncogene in PC-12 cells. Lacal, JC , Cuadrado, A , Jones, JE, Trotta, R, Burstein, DE, Thomson, T, Pellicer, A. Mol. Cell. Biol. - 10 (6) : 2983-2990 (PMID: 2188105)