14 Feb | 2025 Matrix mechano-sensing at the invasive front induces a cytoskeletal and transcriptional memory supporting metastasis. Maiques, O, Sallan, MC, Laddach, R, Pandya, P, Varela, A, Crosas-Molist, E, Barcelo, J, Courbot, O, Liu, Y, Graziani, V, Arafat, Y, Sewell, J, Rodriguez-Hernandez, I, Fanshawe, B, Jung-Garcia, Y, Imbert, PR, Grasset, EM, Albrengues, J, Santacana, M, Macià, A, Tarragona, J, Matias-Guiu, X, Marti, RM, Tsoka, S, Gaggioli, C, Orgaz, JL , Fruhwirth, GO, Wallberg, F, Betteridge, K, Reyes-Aldasoro, CC, Haider, S, Braun, A, Karagiannis, SN, Elosegui-Artola, A, Sanz-Moreno, V . Nat Commun - 16 (1) : 1394 (PMID: 39952917) (doi:10.1038/s41467-025-56299-7)
23 Sep | 2024 Creating a path during melanoma amoeboid migration: When too crowded, start worrying. Orgaz, JL . Dev Cell - 59 (18) : 2395-2397 (PMID: 39317164) (doi:10.1016/j.devcel.2024.07.009)
20 Oct | 2023 CD73 controls Myosin II-driven invasion, metastasis, and immunosuppression in amoeboid pancreatic cancer cells. Samain, R, Maiques, O, Monger, J, Lam, H, Candido, J, George, S, Ferrari, N, KohIhammer, L, Lunetto, S, Varela, A, Orgaz, JL , Vilardell, F, Olsina, JJ, Matias-Guiu, X, Sarker, D, Biddle, A, Balkwill, FR, Eyles, J, Wilkinson, RW, Kocher, HM, Calvo, F , Wells, CM, Sanz-Moreno, V . Sci Adv - 9 (42) : eadi0244 (PMID: 37851808) (doi:10.1126/sciadv.adi0244)
2 Feb | 2022 Cytoskeletal Remodelling as an Achilles' Heel for Therapy Resistance in Melanoma. Barreno, A , Orgaz, JL . Cells - 11 (3) (PMID: 35159327) (doi:10.3390/cells11030518)
20 Sep | 2021 RhoGTPase Signalling in Cancer Progression and Dissemination. Crosas-Molist, E, Samain, R, Kohlhammer, L, Orgaz, J , George, S, Maiques, O, Barcelo, J, Sanz-Moreno, V . Physiol Rev (PMID: 34541899) (doi:10.1152/physrev.00045.2020)
25 Jun | 2021 A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma. Maiques, O, Fanshawe, B, Crosas-Molist, E, Rodriguez-Hernandez, I, Volpe, A, Cantelli, G, Boehme, L, Orgaz, JL , Mardakheh, FK, Sanz-Moreno, V , Fruhwirth, GO. Br J Cancer (PMID: 34172930) (doi:10.1038/s41416-021-01442-6)
20 Oct | 2020 WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion. Rodriguez-Hernandez, I, Maiques, O, Kohlhammer, L, Cantelli, G, Perdrix-Rosell, A, Monger, J, Fanshawe, B, Bridgeman, VL, Karagiannis, SN, Penin, RM, Marcolval, J, Marti, RM, Matias-Guiu, X, Fruhwirth, GO, Orgaz, JL , Malanchi, I, Sanz-Moreno, V . Nat Commun - 11 (1) : 5315 (PMID: 33082334) (doi:10.1038/s41467-020-18951-2)
7 Sep | 2020 CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion. Farrugia, AJ, Rodríguez, J, Orgaz, JL , Lucas, M, Sanz-Moreno, V , Calvo, F . J Cell Biol - 219 (9) (PMID: 32798219) (doi:10.1083/jcb.201912159)
26 Mar | 2020 What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation. Orgaz, JL , Sanz-Moreno, V . Mol Cell Oncol - 7 (3) : 1735911 (PMID: 32391428) (doi:10.1080/23723556.2020.1735911)
13 Jan | 2020 Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance. Orgaz, JL , Crosas-Molist, E, Sadok, A, Perdrix-Rosell, A, Maiques, O, Rodriguez-Hernandez, I, Monger, J, Mele, S, Georgouli, M, Bridgeman, V, Karagiannis, P, Lee, R, Pandya, P, Boehme, L, Wallberg, F, Tape, C, Karagiannis, SN, Malanchi, I, Sanz-Moreno, V . Cancer Cell - 37 (1) : 85-103.e9 (PMID: 31935375) (doi:10.1016/j.ccell.2019.12.003)
7 Feb | 2019 Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment. Georgouli, M, Herraiz, C, Crosas-Molist, E, Fanshawe, B, Maiques, O, Perdrix, A, Pandya, P, Rodriguez-Hernandez, I, Ilieva, KM, Cantelli, G, Karagiannis, P, Mele, S, Lam, H, Josephs, DH, Matias-Guiu, X, Marti, RM, Nestle, FO, Orgaz, JL , Malanchi, I, Fruhwirth, GO, Karagiannis, SN, Sanz-Moreno, V . Cell - 176 (4) : 757-774.e23 (PMID: 30712866) (doi:10.1016/j.cell.2018.12.038)
1 Jul | 2018 T-type calcium channels drive migration/invasion in BRAFV600E melanoma cells through Snail1. Maiques, O, Barceló, C, Panosa, A, Pijuan, J, Orgaz, JL , Rodriguez-Hernandez, I, Matas-Nadal, C, Tell, G, Vilella, R, Fabra, A, Puig, S, Sanz-Moreno, V , Matias-Guiu, X, Canti, C, Herreros, J, Marti, RM, Macià, A. Pigment Cell Melanoma Res - 31 (4) : 484-495 (PMID: 29385656) (doi:10.1111/pcmr.12690)
1 Oct | 2017 Actomyosin contractility and collective migration: may the force be with you. Pandya, P, Orgaz, JL , Sanz-Moreno, V . Curr Opin Cell Biol - 48 : 87-96 (PMID: 28715714) (doi:10.1016/j.ceb.2017.06.006)
1 Jan | 2017 Modes of invasion during tumour dissemination. Pandya, P, Orgaz, JL , Sanz-Moreno, V . Mol Oncol - 11 (1) : 5-27 (PMID: 28085224) (doi:10.1002/1878-0261.12019)
1 Jan | 2016 Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination. Herraiz, C, Calvo, F , Pandya, P, Cantelli, G, Rodriguez-Hernandez, I, Orgaz, JL , Kang, N, Chu, T, Sahai, E, Sanz-Moreno, V . J Natl Cancer Inst - 108 (1) (PMID: 26464464) (doi:10.1093/jnci/djv289)
16 Nov | 2015 TGF-β-Induced Transcription Sustains Amoeboid Melanoma Migration and Dissemination. Cantelli, G, Orgaz, JL , Rodriguez-Hernandez, I, Karagiannis, P, Maiques, O, Matias-Guiu, X, Nestle, FO, Marti, RM, Karagiannis, SN, Sanz-Moreno, V . Curr Biol - 25 (22) : 2899-2914 (PMID: 26526369) (doi:10.1016/j.cub.2015.09.054)
1 Jul | 2015 Microphthalmia-Associated Transcription Factor: A Central Regulator of Pigment Epithelium-Derived Factor Controlling Human Melanoma Progression. Jiménez Cuenca, B , Fernández-Barral, A , Orgaz, JL . Am. J. Pathol. - 185 (7) : 2069-2070 (PMID: 26093986) (doi:10.1016/j.ajpath.2015.03.029)
20 Mar | 2015 Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer. Aguilera, Ó, González-Sancho, JM , Zazo, S, Rincón, R, Fernández, AF, Tapia, O, Canals, F, Morte, B , Calvanese, V, Orgaz, JL , Niell, N , Aguilar, S, Freije, JM, Graña, O, Pisano, DG, Borrero, A, Martínez-Useros, J, Jiménez, B , Fraga, MF, García-Foncillas, J, López-Otín, C, Lafarga, M, Rojo, F, Muñoz, A . Oncotarget - 6 (8) : 5903-5917 (PMID: 25788273) (doi:10.18632/oncotarget.3464)
25 Jun | 2014 Diverse matrix metalloproteinase functions regulate cancer amoeboid migration. Orgaz, JL , Pandya, P, Dalmeida, R, Karagiannis, P, Sanchez-Laorden, B, Viros, A, Albrengues, J, Nestle, FO, Ridley, AJ, Gaggioli, C, Marais, R, Karagiannis, SN, Sanz-Moreno, V . Nat Commun - 5 : 4255 (PMID: 24963846) (doi:10.1038/ncomms5255)
1 Jun | 2014 Regulatory and functional connection of microphthalmia-associated transcription factor and anti-metastatic pigment epithelium derived factor in melanoma. Fernández-Barral, A , Orgaz, JL , Baquero, P, Ali, Z, Moreno, A , Tiana, M, Gómez, V, Riveiro-Falkenbach, E, Cañadas, C, Zazo, S, Bertolotto, C, Davidson, I, Rodríguez-Peralto, JL, Palmero, I , Rojo, F, Jensen, LD, del Peso, L , Jiménez, B . Neoplasia - 16 (6) : 529-542 (PMID: 25030625) (doi:10.1016/j.neo.2014.06.001)
8 May | 2014 Rho GTPases modulate malignant transformation of tumor cells. Orgaz, JL , Herraiz, C, Sanz-Moreno, V . Small GTPases - 5 : e29019 (PMID: 25036871) (doi:10.4161/sgtp.29019)
10 Jul | 2013 (V600E)BRAF promotes invasiveness of thyroid cancer cells by decreasing E-cadherin expression through a Snail-dependent mechanism. Baquero, P, Sánchez-Hernández, I, Jiménez-Mora, E, Orgaz, JL , Jiménez, B , Chiloeches, A. Cancer Lett. - 335 (1) : 232-241 (PMID: 23435375) (doi:10.1016/j.canlet.2013.02.033)
1 Jun | 2013 Cellular plasticity confers migratory and invasive advantages to a population of glioblastoma-initiating cells that infiltrate peritumoral tissue. Ruiz-Ontañon, P, Orgaz, JL , Aldaz, B, Elosegui-Artola, A, Martino, J, Berciano, MT, Montero, JA, Grande, L, Nogueira, L, Diaz-Moralli, S, Esparís-Ogando, A, Vazquez-Barquero, A, Lafarga, M, Pandiella, A, Cascante, M, Segura, V, Martinez-Climent, JA, Sanz-Moreno, V , Fernandez-Luna, JL. Stem Cells - 31 (6) : 1075-1085 (PMID: 23401361) (doi:10.1002/stem.1349)
1 Jan | 2013 Emerging molecular targets in melanoma invasion and metastasis. Orgaz, JL , Sanz-Moreno, V . Pigment Cell Melanoma Res - 26 (1) : 39-57 (PMID: 23095214) (doi:10.1111/pcmr.12041)
23 Mar | 2012 Hypoxia negatively regulates antimetastatic PEDF in melanoma cells by a hypoxia inducible factor-independent, autophagy dependent mechanism. Fernández-Barral, A , Orgaz, JL , Gomez, V, del Peso, L , Calzada, MJ, Jiménez, B . PLoS ONE - 7 (3) : e32989 (PMID: 22457728) (doi:10.1371/journal.pone.0032989)
1 Aug | 2011 Changes in the gene expression profile of A375 human melanoma cells induced by overexpression of multifunctional pigment epithelium-derived factor. Orgaz, JL , Benguria, A, Sanchez-Martinez, C , Ladhani, O, Volpert, OV, Jimenez, B . Melanoma Res. - 21 (4) : 285-297 (PMID: 21673604) (doi:10.1097/CMR.0b013e32834495c3)
13 Jul | 2011 Pigment epithelium-derived factor blocks tumor extravasation by suppressing amoeboid morphology and mesenchymal proteolysis. Ladhani, O, Sánchez-Martinez, C, Orgaz, JL , Jimenez, B , Volpert, OV. Neoplasia - 13 (7) : 633-642 (PMID: 21750657)
10 Feb | 2011 DUSP1/MKP1 promotes angiogenesis, invasion and metastasis in non-small-cell lung cancer. Moncho-Amor, V , Ibañez de Cáceres, I , Bandres, E, Martínez-Poveda, B , Orgaz, JL , Sánchez-Pérez, I , Zazo, S, Rovira, A, Albanell, J, Jiménez, B , Rojo, F, Belda-Iniesta, C , García-Foncillas, J, Perona, R . Oncogene - 30 (6) : 668-678 (PMID: 20890299) (doi:10.1038/onc.2010.449)
16 Nov | 2010 Functional impact of cancer-associated mutations in the tumor suppressor protein ING4. Moreno, A , Palacios, A, Orgaz, JL , Jimenez, B , Blanco, FJ, Palmero, I . Carcinogenesis - 31 (11) : 1932-1938 (PMID: 20705953) (doi:10.1093/carcin/bgq171)
26 Nov | 2009 'Loss of pigment epithelium-derived factor enables migration, invasion and metastatic spread of human melanoma'. Orgaz, JL , Ladhani, O, Hoek, KS, Fernández-Barral, A , Mihic, D, Aguilera, O , Seftor, EA, Bernad, A, Rodríguez-Peralto, JL, Hendrix, MJ, Volpert, OV, Jiménez, B . Oncogene - 28 (47) : 4147-4161 (PMID: 19767774) (doi:10.1038/onc.2009.284)
1 Aug | 2008 Following up tumour angiogenesis: from the basic laboratory to the clinic. Orgaz, JL , Martínez-Poveda, B , Fernández-García, NI , Jiménez, B . Clin Transl Oncol - 10 (8) : 468-477 (PMID: 18667377)