The laboratory led by Dr. Isabel Lastres-Becker specializes in translational research on neurodegenerative diseases, aiming to understand their molecular mechanisms and develop new therapeutic strategies. Our group integrates tools from molecular biology, pharmacology, and neuroscience to address urgent clinical challenges such as Parkinson’s disease, amyotrophic lateral sclerosis (ALS), and tauopathies (including frontotemporal dementia and Alzheimer’s disease).
Our research activities are grounded in a multidisciplinary approach that spans from cellular and animal models to biomarker analysis, enabling the identification of novel therapeutic targets and the preclinical validation of innovative compounds.
Research Lines
1. Cellular Mechanisms of Neurodegeneration
We study key processes such as proteostasis (including mitophagy), oxidative stress, and mitochondrial dysfunction, all implicated in progressive neuronal death. Our focus lies on neuron-glia interactions.
2. Oxidative Stress and Neuroinflammation
We investigate the role of the transcription factor NRF2 as a master regulator of antioxidant and anti-inflammatory responses. We also evaluate the contribution of pyroptosis (inflammation-driven cell death) to neurodegenerative processes. These pathways are targeted for neuroprotective strategies in models of Parkinson’s, Alzheimer’s, and ALS.
3. Endocannabinoid System and Neuroprotection
We explore the selective modulation of the CB2 cannabinoid receptor as a therapeutic approach in tauopathies.
4. Development of Therapeutic Compounds
We actively collaborate in the design and preclinical evaluation of novel molecules with therapeutic potential, including NRF2 activators, kinase inhibitors, and modulators of the endocannabinoid system.
AWARDS
- 2021: Award for the most cited publication published 5 years ago by IdiPAZ
- 2020: IdiPaz Award for the most relevant publication in the area of Neurosciences
- 2019: Award for the most cited publication published 5 years ago by IdiPAZ
- 2019: Special “Arquímedes” Jury Prize, for the Master's Thesis by student Marcos Galán Ganga.
- 2018: I International Congress of the ALS Community Award for the best poster in the RESEARCH category.
- 2015: Award for the most relevant publication in Area 1-Neurosciences of IdiPaz
- 2012: Award for the most relevant publication in Area 1-Neurosciences of IdiPaz
- 2012: Prize for the best oral presentation at the 6th European Congress of Pharmacology.
- 2010: L'Oreal-Unesco Research Grant for Women in Science.