3 Dec | 2024 The CDK12-BRCA1 signaling axis mediates dinaciclib-associated radiosensitivity through p53-mediated cellular senescence. Flores, NG, Fernández-Aroca, DM, Garnés-García, C, Domínguez-Calvo, A, Jiménez-Suárez, J, Sabater, S, Fernández-Aroca, P, Andrés, I, Cimas, FJ, de Cárcer, G , Belandia, B , Palmero, I , Huertas, P, Ruiz-Hidalgo, MJ, Sánchez-Prieto, R . Mol Oncol (PMID: 39626031) (doi:10.1002/1878-0261.13773)
5 Apr | 2023 Dysfunction of programmed embryo senescence is linked to genetic developmental defects. de Lope, C , García-Lucena, R , Magariños, M , León, Y , Casa-Rodríguez, N , Contreras, N , Escudero-Iriarte, C , Varela-Nieto, I , Maire, P, Palmero, I . Development (PMID: 37017267) (doi:10.1242/dev.200903)
30 Mar | 2022 Editorial: The Role of Cellular Senescence in Health and Disease. Palmero, I , Gorgoulis, V, Varela-Nieto, I . Front Cell Neurosci - 16 : 882417 (PMID: 35431814) (doi:10.3389/fncel.2022.882417)
9 Mar | 2022 Dynamic regulation of myofibroblast phenotype in cellular senescence. López-Antona, I , Contreras-Jurado, C , Luque-Martín, L , Carpintero-Leyva, A , González-Méndez, P , Palmero, I . Aging Cell (PMID: 35266275) (doi:10.1111/acel.13580)
11 May | 2021 RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness. Benítez, S, Cordero, A, Santamaría, PG , Redondo-Pedraza, J, Rocha, AS, Collado-Solé, A, Jimenez, M, Sanz-Moreno, A, Yoldi, G, Santos, JC, De Benedictis, I, Gómez-Aleza, C, Da Silva-Álvarez, S, Troulé, K, Gómez-López, G, Alcazar, N, Palmero, I , Collado, M, Serrano, M, Gonzalez-Suarez, E. Dev Cell (PMID: 34004159) (doi:10.1016/j.devcel.2021.04.022)
31 May | 2019 The Tumor Suppressor ING5 Is a Dimeric, Bivalent Recognition Molecule of the Histone H3K4me3 Mark. Ormaza, G, Rodríguez, JA, Ibáñez de Opakua, A, Merino, N, Villate, M, Gorroño, I, Rábano, M, Palmero, I , Vilaseca, M, Kypta, R, Vivanco, MDM, Rojas, AL, Blanco, FJ. J. Mol. Biol. - 431 (12) : 2298-2319 (PMID: 31026448) (doi:10.1016/j.jmb.2019.04.018)
5 Feb | 2019 SIX1 represses senescence and promotes SOX2-mediated cellular plasticity during tumorigenesis. De Lope, C , Martín-Alonso, S , Auzmendi-Iriarte, J, Escudero, C , Mulet, I , Larrasa-Alonso, J , López-Antona, I , Matheu, A, Palmero, I . Sci Rep - 9 (1) : 1412 (PMID: 30723235) (doi:10.1038/s41598-018-38176-0)
23 Jan | 2019 Complementary and distinct roles of autophagy, apoptosis and senescence during early inner ear development. Varela-Nieto, I , Palmero, I , Magariños, M . Hear. Res. (PMID: 30711386) (doi:10.1016/j.heares.2019.01.014)
7 Jul | 2016 The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes. Adrados, I, Larrasa-Alonso, J, Galarreta, A, López-Antona, I, Menéndez, C, Abad, M, Gil, J, Moreno-Bueno, G , Palmero, I . Oncogene - 35 (27) : 3485-3494 (PMID: 26500063) (doi:10.1038/onc.2015.408)
10 Jul | 2015 RhoE is required for contact inhibition and negatively regulates tumor initiation and progression. Hernández-Sánchez, M, Poch, E, Guasch, RM, Ortega, J, López-Almela, I, Palmero, I , Pérez-Roger, I. Oncotarget - 6 (19) : 17479-17490 (PMID: 26036260) (doi:10.18632/oncotarget.4127)
1 Jul | 2014 Increased melanoma formation and dissemination in TyrNRas mice deficient in the tumor suppressor Ing1. Menéndez, C , Adrados, I , Fernández-Barral, A , Jiménez, B , Flores, JM, Cañamero, M, Fuchtbauer, EM, Beermann, F, Palmero, I . Pigment Cell Melanoma Res - 27 (4) : 674-677 (PMID: 24655373) (doi:10.1111/pcmr.12241)
1 Jun | 2014 Regulatory and functional connection of microphthalmia-associated transcription factor and anti-metastatic pigment epithelium derived factor in melanoma. Fernández-Barral, A , Orgaz, JL , Baquero, P, Ali, Z, Moreno, A , Tiana, M, Gómez, V, Riveiro-Falkenbach, E, Cañadas, C, Zazo, S, Bertolotto, C, Davidson, I, Rodríguez-Peralto, JL, Palmero, I , Rojo, F, Jensen, LD, del Peso, L , Jiménez, B . Neoplasia - 16 (6) : 529-542 (PMID: 25030625) (doi:10.1016/j.neo.2014.06.001)
10 Apr | 2014 ING4 regulates a secretory phenotype in primary fibroblasts with dual effects on cell proliferation and tumor growth. Moreno, A, Soleto, I, García-Sanz, P, Moreno-Bueno, G , Palmero, I . Oncogene - 33 (15) : 1945-1953 (PMID: 23604125) (doi:10.1038/onc.2013.145)
1 Oct | 2013 DGCR8-mediated disruption of miRNA biogenesis induces cellular senescence in primary fibroblasts. Gómez-Cabello, D , Adrados, I , Gamarra, D, Kobayashi, H, Takatsu, Y, Takatsu, K, Gil, J, Palmero, I . Aging Cell - 12 (5) : 923-931 (PMID: 23773483) (doi:10.1111/acel.12117)
1 Oct | 2013 microRNA biogenesis and senescence. Gómez-Cabello, D , Adrados, I , Palmero, I . Aging (Albany NY) - 5 (10) : 721-722 (PMID: 24142392)
7 Jun | 2012 Direct promoter induction of p19Arf by Pit-1 explains the dependence receptor RET/Pit-1/p53-induced apoptosis in the pituitary somatotroph cells. Diaz-Rodriguez, E, García-Lavandeira, M, Perez-Romero, S, Senra, A, Cañibano, C, Palmero, I , Borrello, MG, Dieguez, C, Alvarez, CV. Oncogene - 31 (23) : 2824-2835 (PMID: 22020338) (doi:10.1038/onc.2011.458)
30 Mar | 2012 Crystal structure of inhibitor of growth 4 (ING4) dimerization domain reveals functional organization of ING family of chromatin-binding proteins. Culurgioni, S, Muñoz, IG, Moreno, A , Palacios, A, Villate, M, Palmero, I , Montoya, G, Blanco, FJ. J. Biol. Chem. - 287 (14) : 10876-10884 (PMID: 22334692) (doi:10.1074/jbc.M111.330001)
15 Oct | 2011 New role for Spinophilin in tumor suppression. Palmero, I . Cell Cycle - 10 (20) : 3427 (PMID: 22024930) (doi:10.4161/cc.10.20.17527)
1 Feb | 2011 The tumor suppressor ING1 contributes to epigenetic control of cellular senescence. Abad, M , Moreno, A , Palacios, A, Narita, M, Blanco, F, Moreno-Bueno, G , Narita, M, Palmero, I . Aging Cell - 10 (1) : 158-171 (PMID: 21078114) (doi:10.1111/j.1474-9726.2010.00651.x)
16 Nov | 2010 Functional impact of cancer-associated mutations in the tumor suppressor protein ING4. Moreno, A , Palacios, A, Orgaz, JL , Jimenez, B , Blanco, FJ, Palmero, I . Carcinogenesis - 31 (11) : 1932-1938 (PMID: 20705953) (doi:10.1093/carcin/bgq171)
5 Mar | 2010 The dimeric structure and the bivalent recognition of H3K4me3 by the tumor suppressor ING4 suggests a mechanism for enhanced targeting of the HBO1 complex to chromatin. Palacios, A, Moreno, A , Oliveira, BL, Rivera, T , Prieto, J, García, P, Fernández-Fernández, MR, Bernadó, P, Palmero, I , Blanco, FJ. J. Mol. Biol. - 396 (4) : 1117-1127 (PMID: 20053357) (doi:10.1016/j.jmb.2009.12.049)
1 Mar | 2010 Regulation of the microRNA processor DGCR8 by the tumor suppressor ING1. Gómez-Cabello, D , Callejas, S, Benguría, A, Moreno, A , Alonso, J , Palmero, I . Cancer Res. - 70 (5) : 1866-1874 (PMID: 20179197) (doi:10.1158/0008-5472.CAN-09-2088)
15 May | 2009 ING proteins in cellular senescence. Menéndez, C , Abad, M , Gómez-Cabello, D , Moreno, A , Palmero, I . Curr Drug Targets - 10 (5) : 406-417 (PMID: 19442113)
19 Oct | 2007 Ing1 mediates p53 accumulation and chromatin modification in response to oncogenic stress. Abad, M , Menéndez, C , Füchtbauer, A, Serrano, M, Füchtbauer, EM, Palmero, I . J. Biol. Chem. - 282 (42) : 31060-31067 (PMID: 17693408) (doi:10.1074/jbc.M701639200)
24 Aug | 2006 A functional link between the tumour suppressors ARF and p33ING1. González, L, Freije, JM, Cal, S, López-Otín, C, Serrano, M , Palmero, I . Oncogene - 25 (37) : 5173-5179 (PMID: 16607280) (doi:10.1038/sj.onc.1209526)
18 Jan | 2005 Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras. Goeman, F, Thormeyer, D, Abad, M, Serrano, M, Schmidt, O, Palmero, I , Baniahmad, A. Mol. Cell. Biol. - 25 (1) : 422-431 (PMID: 15601862) (doi:10.1128/MCB.25.1.422-431.2005)
2 May | 2002 Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2. Palmero, I , Murga, M, Zubiaga, A, Serrano, M. Oncogene - 21 (19) : 2939-2947 (PMID: 12082524) (doi:10.1038/sj.onc.1205371)
1 Aug | 2001 Identification of the gene immediately downstream of the murine INK4a/ARF locus. Pantoja, C , Palmero, I , Serrano, M . Exp Gerontol - 36 (8) : 1289-1302 (PMID: 11602205) (doi:10.1016/s0531-5565(01)00104-8)
10 Sep | 1998 p19ARF links the tumour suppressor p53 to Ras. Palmero, I , Pantoja, C , Serrano, M . Nature - 395 (6698) : 125-126 (PMID: 9744268) (doi:10.1038/25870)
1 Sep | 1998 The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. Stott, FJ, Bates, S, James, MC, McConnell, BB, Starborg, M, Brookes, S, Palmero, I , Ryan, K, Hara, E, Vousden, KH, Peters, G. EMBO J. - 17 (17) : 5001-5014 (PMID: 9724636) (doi:10.1093/emboj/17.17.5001)
31 Jul | 1997 Accumulation of p16INK4a in mouse fibroblasts as a function of replicative senescence and not of retinoblastoma gene status. Palmero, I , McConnell, B, Parry, D, Brookes, S, Hara, E, Bates, S, Jat, P, Peters, G. Oncogene - 15 (5) : 495-503 (PMID: 9247303) (doi:10.1038/sj.onc.1201212)
9 Feb | 1995 Expression of cyclin D2 in Epstein-Barr virus-positive Burkitt's lymphoma cell lines is related to methylation status of the gene. Sinclair, AJ, Palmero, I , Holder, A, Peters, G, Farrell, PJ. J. Virol. - 69 (2) : 1292-1295 (PMID: 7529333)
15 Sep | 1991 Cloning of a cDNA encoding an Artemia franciscana Na/K ATPase alpha-subunit. Macías, MT , Palmero, I , Sastre, L . Gene - 105 (2) : 197-204 (PMID: 1657719)
20 Dec | 1989 Complementary DNA cloning of a protein highly homologous to mammalian sarcoplasmic reticulum Ca-ATPase from the crustacean Artemia. Palmero, I , Sastre, L . J. Mol. Biol. - 210 (4) : 737-748 (PMID: 2533270)
31 Jul | 1989 Differential expression of a gene highly homologous to c-ras during the development of the brine shrimp Artemia. Díaz-Guerra, M , Quintanilla, M , Palmero, I , Sastre, L , Renart, J . Biochem. Biophys. Res. Commun. - 162 (2) : 802-808 (PMID: 2502981)
7 Sep | 1988 Isolation of cDNA clones coding for mitochondrial 16S ribosomal RNA from the crustacean Artemia. Palmero, I , Renart, J , Sastre, L . Gene - 68 (2) : 239-248 (PMID: 3220256)