29 Oct | 2024 Immunological and molecular features of the tumor microenvironment of long-term survivors of ovarian cancer. Nelson, BH, Hamilton, PT, Phung, MT, Milne, K, Harris, B, Thornton, S, Stevens, DL, Kalaria, S, Singh, K, Laumont, CM, Moss, E, Alimujiang, A, Meagher, NS, Bolithon, A, Fereday, S, Kennedy, CJ, Hendley, J, Ariyaratne, D, Alsop, K, Traficante, N, Goode, EL, Karnezis, AN, Shen, H, Richardson, J, McKinnon Deurloo, C, Chase, A, Grout, B, Doherty, JA, Harris, HR, Cushing-Haugen, KL, Anglesio, MS, Heinze, K, Huntsman, D, Talhouk, A, Hanley, GE, Alsop, J, Jimenez-Linan, M, Pharoah, PD, Boros, J, Brand, AH, Harnett, PR, Sharma, R, Hecht, JL, Sasamoto, N, Terry, KL, Karlan, BY, Lester, J, Carney, ME, Goodman, MT, Hernandez, BY, Wilkens, LR, Behrens, S, Turzanski Fortner, R, Fasching, PA, Bisinotto, C, Candido Dos Reis, FJ, Ghatage, P, Köbel, M, Elishaev, E, Modugno, F, Cook, LS, Le, ND, Gentry-Maharaj, A, Menon, U, García, MJ , Rodriguez-Antona, C , Farrington, KM, Kelemen, LE, Kommoss, S, Staebler, A, Garsed, DW, Brenton, JD, Piskorz, AM, Bowtell, DD, DeFazio, A, Ramus, SJ, Pike, MC, Pearce, CL. J Clin Invest (PMID: 39470729) (doi:10.1172/JCI179501)
4 Oct | 2024 Retrospective study assessing the role of the androgen receptor in clear cell renal cell cancer patients treated with VEGFR inhibitors in monotherapy. Osorio, L, Grazioso, TP, de Velasco, G, Etxaniz, O, Pérez-Gracia, JL, Pinto, Á, Durán, I, Grande, E, Garcia, PB, Lázaro, M, Rodriguez, L, Villalobos, ML, García, L, Cuellar, A, Solís-Hernández, MP, Pernaut, C, Rodríguez-Moreno, JF, Rodriguez-Antona, C , García-Donas, J. Clin Transl Oncol (PMID: 39365364) (doi:10.1007/s12094-024-03652-9)
29 Aug | 2024 MAML3-fusions modulate vascular and immune tumour microenvironment and confer high metastatic risk in pheochromocytoma and paraganglioma. Monteagudo, M, Calsina, B, Salazar-Hidalgo, ME, Martínez-Montes, ÁM, Piñeiro-Yáñez, E, Caleiras, E, Martín, MC, Rodríguez-Perales, S, Letón, R, Gil, E, Buffet, A, Burnichon, N, Fernández-Sanromán, Á, Díaz-Talavera, A, Mellid, S, Arroba, E, Reglero, C, Martínez-Puente, N, Roncador, G, Del Olmo, MI, Corrales, PJP, Oliveira, CL, Álvarez-Escolá, C, Gutiérrez, MC, López-Fernández, A, García, NP, Regojo, RM, Díaz, LR, Laorden, NR, Guadarrama, OS, Bechmann, N, Beuschlein, F, Canu, L, Eisenhofer, G, Fassnacht, M, Nölting, S, Quinkler, M, Rapizzi, E, Remde, H, Timmers, HJ, Favier, J, Gimenez-Roqueplo, AP, Rodriguez-Antona, C , Currás-Freixes, M, Al-Shahrour, F, Cascón, A, Leandro-García, LJ, Montero-Conde, C , Robledo, M. Best Pract Res Clin Endocrinol Metab (PMID: 39218714) (doi:10.1016/j.beem.2024.101931)
13 Aug | 2024 PharmVar GeneFocus: CYP4F2. Zubiaur, P, Rodríguez-Antona, C , Boone, EC, Daly, AK, Tsermpini, EE, Khasawneh, LQ, Sangkuhl, K, Duconge, J, Botton, MR, Savieo, J, Nofziger, C, Whirl-Carrillo, M, Klein, TE, Gaedigk, A. Clin Pharmacol Ther (PMID: 39135485) (doi:10.1002/cpt.3405)
6 Jun | 2024 Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions. Dareng, EO, Coetzee, SG, Tyrer, JP, Peng, PC, Rosenow, W, Chen, S, Davis, BD, Dezem, FS, Seo, JH, Nameki, R, Reyes, AL, Aben, KKH, Anton-Culver, H, Antonenkova, NN, Aravantinos, G, Bandera, EV, Beane Freeman, LE, Beckmann, MW, Beeghly-Fadiel, A, Benitez, J, Bernardini, MQ, Bjorge, L, Black, A, Bogdanova, NV, Bolton, KL, Brenton, JD, Budzilowska, A, Butzow, R, Cai, H, Campbell, I, Cannioto, R, Chang-Claude, J, Chanock, SJ, Chen, K, Chenevix-Trench, G, , , Chiew, YE, Cook, LS, DeFazio, A, Dennis, J, Doherty, JA, Dörk, T, du Bois, A, Dürst, M, Eccles, DM, Ene, G, Fasching, PA, Flanagan, JM, Fortner, RT, Fostira, F, Gentry-Maharaj, A, Giles, GG, Goodman, MT, Gronwald, J, Haiman, CA, Håkansson, N, Heitz, F, Hildebrandt, MAT, Høgdall, E, Høgdall, CK, Huang, RY, Jensen, A, Jones, ME, Kang, D, Karlan, BY, Karnezis, AN, Kelemen, LE, Kennedy, CJ, Khusnutdinova, EK, Kiemeney, LA, Kjaer, SK, Kupryjanczyk, J, Labrie, M, Lambrechts, D, Larson, MC, Le, ND, Lester, J, Li, L, Lubiński, J, Lush, M, Marks, JR, Matsuo, K, May, T, McLaughlin, JR, McNeish, IA, Menon, U, Missmer, S, Modugno, F, Moffitt, M, Monteiro, AN, Moysich, KB, Narod, SA, Nguyen-Dumont, T, Odunsi, K, Olsson, H, Onland-Moret, NC, Park, SK, Pejovic, T, Permuth, JB, Piskorz, A, Prokofyeva, D, Riggan, MJ, Risch, HA, Rodríguez-Antona, C , Rossing, MA, Sandler, DP, Setiawan, VW, Shan, K, Song, H, Southey, MC, Steed, H, Sutphen, R, Swerdlow, AJ, Teo, SH, Terry, KL, Thompson, PJ, Vestrheim Thomsen, LC, Titus, L, Trabert, B, Travis, R, Tworoger, SS, Valen, E, Van Nieuwenhuysen, E, Edwards, DV, Vierkant, RA, Webb, PM, , , Weinberg, CR, Weise, RM, Wentzensen, N, White, E, Winham, SJ, Wolk, A, Woo, YL, Wu, AH, Yan, L, Yannoukakos, D, Zeinomar, N, Zheng, W, Ziogas, A, Berchuck, A, Goode, EL, Huntsman, DG, Pearce, CL, Ramus, SJ, Sellers, TA, , , Freedman, ML, Lawrenson, K, Schildkraut, JM, Hazelett, D, Plummer, JT, Kar, S, Jones, MR, Pharoah, PDP, Gayther, SA. Am J Hum Genet - 111 (6) : 1061-1083 (PMID: 38723632) (doi:10.1016/j.ajhg.2024.04.011)
28 Apr | 2024 Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma. Mahmood, M, Liu, EM, Shergold, AL, Tolla, E, Tait-Mulder, J, Huerta-Uribe, A, Shokry, E, Young, AL, Lilla, S, Kim, M, Park, T, Boscenco, S, Manchon, JL, Rodríguez-Antona, C , Walters, RC, Springett, RJ, Blaza, JN, Mitchell, L, Blyth, K, Zanivan, S, Sumpton, D, Roberts, EW, Reznik, E, Gammage, PA. Nat Cancer - 5 (4) : 659-672 (PMID: 38286828) (doi:10.1038/s43018-023-00721-w)
5 Mar | 2024 Genome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease. Ramachandran, D, Tyrer, JP, Kommoss, S, DeFazio, A, Riggan, MJ, , , Webb, PM, Fasching, PA, Lambrechts, D, García, MJ , Rodríguez-Antona, C , Goodman, MT, Modugno, F, Moysich, KB, Karlan, BY, Lester, J, Kjaer, SK, Jensen, A, Høgdall, E, Goode, EL, Cliby, WA, Kumar, A, Wang, C, Cunningham, JM, Winham, SJ, Monteiro, AN, Schildkraut, JM, Cramer, DW, Terry, KL, Titus, L, Bjorge, L, Thomsen, LCV, , , Pejovic, T, Høgdall, CK, McNeish, IA, May, T, Huntsman, DG, Pfisterer, J, Canzler, U, Park-Simon, TW, Schröder, W, Belau, A, Hanker, L, Harter, P, Sehouli, J, Kimmig, R, de Gregorio, N, Schmalfeldt, B, Baumann, K, Hilpert, F, Burges, A, Winterhoff, B, Schürmann, P, Speith, LM, Hillemanns, P, Berchuck, A, Johnatty, SE, Ramus, SJ, Chenevix-Trench, G, Pharoah, PDP, Dörk, T, Heitz, F. NPJ Genom Med - 9 (1) : 19 (PMID: 38443389) (doi:10.1038/s41525-024-00395-y)
15 Sep | 2023 Deubiquitinase USP9X loss sensitizes renal cancer cells to mTOR inhibition. Roldán-Romero, JM, Valdivia, C, Santos, M, Lanillos, J, Maroto, P, Anguera, G, Calsina, B, Martinez-Montes, A, Monteagudo, M, Mellid, S, Leandro-García, LJ, Montero-Conde, C , Cascón, A, Roncador, G, Coloma, J, Robledo, M, Rodriguez-Antona, C . Int J Cancer - 153 (6) : 1300-1312 (PMID: 37260183) (doi:10.1002/ijc.34575)
21 Jul | 2023 DLST mutations in pheochromocytoma and paraganglioma cause proteome hyposuccinylation and metabolic remodeling. Mellid, S, García, F, Leandro-García, LJ, Díaz-Talavera, A, Martínez-Montes, ÁM, Gil, E, Calsina, B, Monteagudo, M, Letón, R, Roldán-Romero, JM, Santos, M, Lanillos, J, Valdivia, C, Martínez-Puente, N, de Nicolás-Hernández, J, Jiménez, S, Pérez-Martínez, M, Honrado, E, Coloma, J, Cerezo, A, Santiveri, CM, Esteller, M, Campos-Olivas, R, Caleiras, E, Montero-Conde, C , Rodríguez-Antona, C , Muñoz, J, Robledo, M, Cascón, A. Cancer Commun (Lond) - 43 (7) : 838-843 (PMID: 37139660) (doi:10.1002/cac2.12427)
27 Jun | 2023 Clinical parameters affecting survival outcomes in patients with low-grade serous ovarian carcinoma: an international multicentre analysis. May, T, Bernardini, M, Lheureux, S, Aben, KKH, Bandera, EV, Beckmann, MW, Benitez, J, Berchuck, A, Bjørge, L, Carney, ME, Cramer, DW, deFazio, A, Dörk, T, Eccles, DM, Friedlander, M, García, MJ, Goode, EL, Hein, A, Høgdall, CK, Jensen, A, Johnatty, S, Kennedy, CJ, Kiemeney, LA, Kjær, SK, Kupryjańczyk, J, Matsuo, K, McGuire, V, Modugno, F, Paddock, LE, Pejovic, T, Phelan, CM, Riggan, MJ, Rodriguez-Antona, C , Rothstein, JH, Sieh, W, Song, H, Terry, KL, van Altena, AM, Vanderstichele, A, Vergote, I, Thomsen, LCV, Webb, PM, Wentzensen, N, Wilkens, LR, Ziogas, A, Jiang, H, Tone, A, , . Can J Surg - 66 (3) : E310-E320 (PMID: 37369443) (doi:10.1503/cjs.017020)
15 May | 2023 PBRM1 and KDM5C cooperate to define high-angiogenesis tumors and increased antiangiogenic response in renal cancer. Santos, M, Lanillos, J, Caleiras, E, Valdivia, C, Roldan-Romero, JM, Laínez, N, Puente, J, Beuselinck, B, Oudard, S, Zucman-Rossi, J, Navarro, P, Robledo, M, Castellano, D, de Velasco, G, García-Donas, J, Rodriguez-Antona, C . Am J Cancer Res - 13 (5) : 2116-2125 (PMID: 37293154)
23 Mar | 2023 Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade. Mahmood, M, Liu, EM, Shergold, AL, Tolla, E, Tait-Mulder, J, Huerta Uribe, A, Shokry, E, Young, AL, Lilla, S, Kim, M, Park, T, Manchon, JL, Rodríguez-Antona, C , Walters, RC, Springett, RJ, Blaza, JN, Zanivan, S, Sumpton, D, Roberts, EW, Reznik, E, Gammage, PA. bioRxiv (PMID: 36993533) (doi:10.1101/2023.03.21.533091)
1 Mar | 2023 CCNE1 and survival of patients with tubo-ovarian high-grade serous carcinoma: An Ovarian Tumor Tissue Analysis consortium study. Kang, EY, Weir, A, Meagher, NS, Farrington, K, Nelson, GS, Ghatage, P, Lee, CH, Riggan, MJ, Bolithon, A, Popovic, G, Leung, B, Tang, K, Lambie, N, Millstein, J, Alsop, J, Anglesio, MS, Ataseven, B, Barlow, E, Beckmann, MW, Berger, J, Bisinotto, C, Bösmüller, H, Boros, J, Brand, AH, Brooks-Wilson, A, Brucker, SY, Carney, ME, Casablanca, Y, Cazorla-Jiménez, A, Cohen, PA, Conrads, TP, Cook, LS, Coulson, P, Courtney-Brooks, M, Cramer, DW, Crowe, P, Cunningham, JM, Cybulski, C, Darcy, KM, El-Bahrawy, MA, Elishaev, E, Erber, R, Farrell, R, Fereday, S, Fischer, A, García, MJ , Gayther, SA, Gentry-Maharaj, A, Gilks, CB, , , Grube, M, Harnett, PR, Harrington, SP, Harter, P, Hartmann, A, Hecht, JL, Heikaus, S, Hein, A, Heitz, F, Hendley, J, Hernandez, BY, Polo, SH, Heublein, S, Hirasawa, A, Høgdall, E, Høgdall, CK, Horlings, HM, Huntsman, DG, Huzarski, T, Jewell, A, Jimenez-Linan, M, Jones, ME, Kaufmann, SH, Kennedy, CJ, Khabele, D, Kommoss, FKF, Kruitwagen, RFPM, Lambrechts, D, Le, ND, Lener, M, Lester, J, Leung, Y, Linder, A, Loverix, L, Lubiński, J, Madan, R, Maxwell, GL, Modugno, F, Neuhausen, SL, Olawaiye, A, Olbrecht, S, Orsulic, S, Palacios, J, Pearce, CL, Pike, MC, Quinn, CM, Mohan, GR, Rodríguez-Antona, C , Ruebner, M, Ryan, A, Salfinger, SG, Sasamoto, N, Schildkraut, JM, Schoemaker, MJ, Shah, M, Sharma, R, Shvetsov, YB, Singh, N, Sonke, GS, Steele, L, Stewart, CJR, Sundfeldt, K, Swerdlow, AJ, Talhouk, A, Tan, A, Taylor, SE, Terry, KL, Tołoczko, A, Traficante, N, Van de Vijver, KK, van der Aa, MA, Van Gorp, T, Van Nieuwenhuysen, E, van-Wagensveld, L, Vergote, I, Vierkant, RA, Wang, C, Wilkens, LR, Winham, SJ, Wu, AH, Benitez, J, Berchuck, A, Candido Dos Reis, FJ, DeFazio, A, Fasching, PA, Goode, EL, Goodman, MT, Gronwald, J, Karlan, BY, Kommoss, S, Menon, U, Sinn, HP, Staebler, A, Brenton, JD, Bowtell, DD, Pharoah, PDP, Ramus, SJ, Köbel, M. Cancer - 129 (5) : 697-713 (PMID: 36572991) (doi:10.1002/cncr.34582)
28 Feb | 2023 Genomic and immune landscape Of metastatic pheochromocytoma and paraganglioma. Calsina, B, Piñeiro-Yáñez, E, Martínez-Montes, ÁM, Caleiras, E, Fernández-Sanromán, Á, Monteagudo, M, Torres-Pérez, R, Fustero-Torre, C, Pulgarín-Alfaro, M, Gil, E, Letón, R, Jiménez, S, García-Martín, S, Martin, MC, Roldán-Romero, JM, Lanillos, J, Mellid, S, Santos, M, Díaz-Talavera, A, Rubio, Á, González, P, Hernando, B, Bechmann, N, Dona, M, Calatayud, M, Guadalix, S, Álvarez-Escolá, C, Regojo, RM, Aller, J, Del Olmo-Garcia, MI, López-Fernández, A, Fliedner, SMJ, Rapizzi, E, Fassnacht, M, Beuschlein, F, Quinkler, M, Toledo, RA, Mannelli, M, Timmers, HJ, Eisenhofer, G, Rodríguez-Perales, S, Domínguez, O, Macintyre, G, Currás-Freixes, M, Rodríguez-Antona, C , Cascón, A, Leandro-García, LJ, Montero-Conde, C , Roncador, G, García-García, JF, Pacak, K, Al-Shahrour, F, Robledo, M. Nat Commun - 14 (1) : 1122 (PMID: 36854674) (doi:10.1038/s41467-023-36769-6)
1 Dec | 2022 PharmVar GeneFocus: CYP3A5. Rodriguez-Antona, C , Savieo, JL, Lauschke, VM, Sangkuhl, K, Drögemöller, BI, Wang, D, van Schaik, RHN, Gilep, AA, Peter, AP, Boone, EC, Ramey, BE, Klein, TE, Whirl-Carrillo, M, Pratt, VM, Gaedigk, A. Clin Pharmacol Ther - 112 (6) : 1159-1171 (PMID: 35202484) (doi:10.1002/cpt.2563)
1 Sep | 2022 Interrogating the Significance of PARP1 Expression and PBRM1 Mutation as Biomarkers for Predicting the Response to Atezolizumab plus Bevacizumab or to Sunitinib in Patients with Clear Cell Renal Cell Carcinoma. Lanillos, J, Santos, M, Valdivia, C, Mora, A, Rodríguez-Antona, C . Eur Urol - 82 (3) : 334-335 (PMID: 35688666) (doi:10.1016/j.eururo.2022.05.013)
19 Aug | 2022 Comprehensive molecular analysis of immortalization hallmarks in thyroid cancer reveals new prognostic markers. Montero-Conde, C , Leandro-García, LJ, Martínez-Montes, ÁM, Martínez, P, Moya, FJ, Letón, R, Gil, E, Martínez-Puente, N, Guadalix, S, Currás-Freixes, M, García-Tobar, L, Zafon, C, Jordà, M, Riesco-Eizaguirre, G , González-García, P, Monteagudo, M, Torres-Pérez, R, Mancikova, V, Ruiz-Llorente, S , Pérez-Martínez, M, Pita, G, Galofré, JC, Gonzalez-Neira, A, Cascón, A, Rodríguez-Antona, C , Megías, D, Blasco, MA, Caleiras, E, Rodríguez-Perales, S, Robledo, M. Clin Transl Med - 12 (8) : e1001 (PMID: 35979662) (doi:10.1002/ctm2.1001)
30 Jul | 2022 Cabozantinib combination therapy for the treatment of solid tumors: a systematic review. Castellano, D, Apolo, AB, Porta, C, Capdevila, J, Viteri, S, Rodriguez-Antona, C , Martin, L, Maroto, P. Ther Adv Med Oncol - 14 : 17588359221108691 (PMID: 35923927) (doi:10.1177/17588359221108691)
26 Jul | 2022 Single-nucleotide polymorphism associations with efficacy and toxicity in metastatic castration-resistant prostate cancer treated with cabazitaxel. Herrero Rivera, D, Vacas, CG, Kovandzic, LM, Vázquez, JP, Alonso, LA, González, BM, Aragón, VC, Grande, E, Caro, RL, Virizuela Echaburu, JA, Rodríguez Moreno, JF, Etxebarria, AA, Rodríguez-Antona, C , Durán, I. Pharmacogenomics - 23 (11) : 627-638 (PMID: 35880554) (doi:10.2217/pgs-2022-0023)
13 Jul | 2022 Cabozantinib for the treatment of solid tumors: a systematic review. Maroto, P, Porta, C, Capdevila, J, Apolo, AB, Viteri, S, Rodriguez-Antona, C , Martin, L, Castellano, D. Ther Adv Med Oncol - 14 : 17588359221107112 (PMID: 35847482) (doi:10.1177/17588359221107112)
8 Jun | 2022 Genome-Wide Meta-Analysis Identifies Variants in DSCAM and PDLIM3 That Correlate with Efficacy Outcomes in Metastatic Renal Cell Carcinoma Patients Treated with Sunitinib. Diekstra, MHM, Swen, JJ, van der Zanden, LFM, Vermeulen, SH, Boven, E, Mathijssen, RHJ, Fukunaga, K, Mushiroda, T, Hongo, F, Oosterwijk, E, Cambon-Thomsen, A, Castellano, D, Fritsch, A, Donas, JG, Rodriguez-Antona, C , Ruijtenbeek, R, Radu, MT, Eisen, T, Junker, K, Roessler, M, Jaehde, U, Miki, T, Böhringer, S, Kubo, M, Kiemeney, LALM, Guchelaar, HJ. Cancers (Basel) - 14 (12) (PMID: 35740506) (doi:10.3390/cancers14122838)
1 May | 2022 Correction: Polygenic risk modeling for prediction of epithelial ovarian cancer risk. Dareng, EO, Tyrer, JP, Barnes, DR, Jones, MR, Yang, X, Aben, KKH, Adank, MA, Agata, S, Andrulis, IL, Anton-Culver, H, Antonenkova, NN, Aravantinos, G, Arun, BK, Augustinsson, A, Balmaña, J, Bandera, EV, Barkardottir, RB, Barrowdale, D, Beckmann, MW, Beeghly-Fadiel, A, Benitez, J, Bermisheva, M, Bernardini, MQ, Bjorge, L, Black, A, Bogdanova, NV, Bonanni, B, Borg, A, Brenton, JD, Budzilowska, A, Butzow, R, Buys, SS, Cai, H, Caligo, MA, Campbell, I, Cannioto, R, Cassingham, H, Chang-Claude, J, Chanock, SJ, Chen, K, Chiew, YE, Chung, WK, Claes, KBM, Colonna, S, , , , , , , Cook, LS, Couch, FJ, Daly, MB, Dao, F, Davies, E, de la Hoya, M, de Putter, R, Dennis, J, DePersia, A, Devilee, P, Diez, O, Ding, YC, Doherty, JA, Domchek, SM, Dörk, T, du Bois, A, Dürst, M, Eccles, DM, Eliassen, HA, Engel, C, Evans, GD, Fasching, PA, Flanagan, JM, Fortner, RT, Machackova, E, Friedman, E, Ganz, PA, Garber, J, Gensini, F, Giles, GG, Glendon, G, Godwin, AK, Goodman, MT, Greene, MH, Gronwald, J, , , , , Hahnen, E, Haiman, CA, Håkansson, N, Hamann, U, Hansen, TVO, Harris, HR, Hartman, M, Heitz, F, Hildebrandt, MAT, Høgdall, E, Høgdall, CK, Hopper, JL, Huang, RY, Huff, C, Hulick, PJ, Huntsman, DG, Imyanitov, EN, , , , , Isaacs, C, Jakubowska, A, James, PA, Janavicius, R, Jensen, A, Johannsson, OT, John, EM, Jones, ME, Kang, D, Karlan, BY, Karnezis, A, Kelemen, LE, Khusnutdinova, E, Kiemeney, LA, Kim, BG, Kjaer, SK, Komenaka, I, Kupryjanczyk, J, Kurian, AW, Kwong, A, Lambrechts, D, Larson, MC, Lazaro, C, Le, ND, Leslie, G, Lester, J, Lesueur, F, Levine, DA, Li, L, Li, J, Loud, JT, Lu, KH, Lubiński, J, Mai, PL, Manoukian, S, Marks, JR, Matsuno, RK, Matsuo, K, May, T, McGuffog, L, McLaughlin, JR, McNeish, IA, Mebirouk, N, Menon, U, Miller, A, Milne, RL, Minlikeeva, A, Modugno, F, Montagna, M, Moysich, KB, Munro, E, Nathanson, KL, Neuhausen, SL, Nevanlinna, H, Yie, JNY, Nielsen, HR, Nielsen, FC, Nikitina-Zake, L, Odunsi, K, Offit, K, Olah, E, Olbrecht, S, Olopade, OI, Olson, SH, Olsson, H, Osorio, A, Papi, L, Park, SK, Parsons, MT, Pathak, H, Pedersen, IS, Peixoto, A, Pejovic, T, Perez-Segura, P, Permuth, JB, Peshkin, B, Peterlongo, P, Piskorz, A, Prokofyeva, D, Radice, P, Rantala, J, Riggan, MJ, Risch, HA, Rodriguez-Antona, C , Ross, E, Rossing, MA, Runnebaum, I, Sandler, DP, Santamariña, M, Soucy, P, Schmutzler, RK, Setiawan, VW, Shan, K, Sieh, W, Simard, J, Singer, CF, Sokolenko, AP, Song, H, Southey, MC, Steed, H, Stoppa-Lyonnet, D, Sutphen, R, Swerdlow, AJ, Tan, YY, Teixeira, MR, Teo, SH, Terry, KL, Terry, MB, , , , , Thomassen, M, Thompson, PJ, Thomsen, LCV, Thull, DL, Tischkowitz, M, Titus, L, Toland, AE, Torres, D, Trabert, B, Travis, R, Tung, N, Tworoger, SS, Valen, E, van Altena, AM, van der Hout, AH, Van Nieuwenhuysen, E, van Rensburg, EJ, Vega, A, Edwards, DV, Vierkant, RA, Wang, F, Wappenschmidt, B, Webb, PM, Weinberg, CR, Weitzel, JN, Wentzensen, N, White, E, Whittemore, AS, Winham, SJ, Wolk, A, Woo, YL, Wu, AH, Yan, L, Yannoukakos, D, Zavaglia, KM, Zheng, W, Ziogas, A, Zorn, KK, Kleibl, Z, Easton, D, Lawrenson, K, DeFazio, A, Sellers, TA, Ramus, SJ, Pearce, CL, Monteiro, AN, Cunningham, J, Goode, EL, Schildkraut, JM, Berchuck, A, Chenevix-Trench, G, Gayther, SA, Antoniou, AC, Pharoah, PDP. Eur J Hum Genet - 30 (5) : 630-631 (PMID: 35314806) (doi:10.1038/s41431-022-01085-y)
1 Mar | 2022 Polygenic risk modeling for prediction of epithelial ovarian cancer risk. Dareng, EO, Tyrer, JP, Barnes, DR, Jones, MR, Yang, X, Aben, KKH, Adank, MA, Agata, S, Andrulis, IL, Anton-Culver, H, Antonenkova, NN, Aravantinos, G, Arun, BK, Augustinsson, A, Balmaña, J, Bandera, EV, Barkardottir, RB, Barrowdale, D, Beckmann, MW, Beeghly-Fadiel, A, Benitez, J, Bermisheva, M, Bernardini, MQ, Bjorge, L, Black, A, Bogdanova, NV, Bonanni, B, Borg, A, Brenton, JD, Budzilowska, A, Butzow, R, Buys, SS, Cai, H, Caligo, MA, Campbell, I, Cannioto, R, Cassingham, H, Chang-Claude, J, Chanock, SJ, Chen, K, Chiew, YE, Chung, WK, Claes, KBM, Colonna, S, , , , , , , Cook, LS, Couch, FJ, Daly, MB, Dao, F, Davies, E, de la Hoya, M, de Putter, R, Dennis, J, DePersia, A, Devilee, P, Diez, O, Ding, YC, Doherty, JA, Domchek, SM, Dörk, T, du Bois, A, Dürst, M, Eccles, DM, Eliassen, HA, Engel, C, Evans, GD, Fasching, PA, Flanagan, JM, Fortner, RT, Machackova, E, Friedman, E, Ganz, PA, Garber, J, Gensini, F, Giles, GG, Glendon, G, Godwin, AK, Goodman, MT, Greene, MH, Gronwald, J, , , , , Hahnen, E, Haiman, CA, Håkansson, N, Hamann, U, Hansen, TVO, Harris, HR, Hartman, M, Heitz, F, Hildebrandt, MAT, Høgdall, E, Høgdall, CK, Hopper, JL, Huang, RY, Huff, C, Hulick, PJ, Huntsman, DG, Imyanitov, EN, , , , , Isaacs, C, Jakubowska, A, James, PA, Janavicius, R, Jensen, A, Johannsson, OT, John, EM, Jones, ME, Kang, D, Karlan, BY, Karnezis, A, Kelemen, LE, Khusnutdinova, E, Kiemeney, LA, Kim, BG, Kjaer, SK, Komenaka, I, Kupryjanczyk, J, Kurian, AW, Kwong, A, Lambrechts, D, Larson, MC, Lazaro, C, Le, ND, Leslie, G, Lester, J, Lesueur, F, Levine, DA, Li, L, Li, J, Loud, JT, Lu, KH, Lubiński, J, Mai, PL, Manoukian, S, Marks, JR, Matsuno, RK, Matsuo, K, May, T, McGuffog, L, McLaughlin, JR, McNeish, IA, Mebirouk, N, Menon, U, Miller, A, Milne, RL, Minlikeeva, A, Modugno, F, Montagna, M, Moysich, KB, Munro, E, Nathanson, KL, Neuhausen, SL, Nevanlinna, H, Yie, JNY, Nielsen, HR, Nielsen, FC, Nikitina-Zake, L, Odunsi, K, Offit, K, Olah, E, Olbrecht, S, Olopade, OI, Olson, SH, Olsson, H, Osorio, A, Papi, L, Park, SK, Parsons, MT, Pathak, H, Pedersen, IS, Peixoto, A, Pejovic, T, Perez-Segura, P, Permuth, JB, Peshkin, B, Peterlongo, P, Piskorz, A, Prokofyeva, D, Radice, P, Rantala, J, Riggan, MJ, Risch, HA, Rodriguez-Antona, C , Ross, E, Rossing, MA, Runnebaum, I, Sandler, DP, Santamariña, M, Soucy, P, Schmutzler, RK, Setiawan, VW, Shan, K, Sieh, W, Simard, J, Singer, CF, Sokolenko, AP, Song, H, Southey, MC, Steed, H, Stoppa-Lyonnet, D, Sutphen, R, Swerdlow, AJ, Tan, YY, Teixeira, MR, Teo, SH, Terry, KL, Terry, MB, , , , , Thomassen, M, Thompson, PJ, Thomsen, LCV, Thull, DL, Tischkowitz, M, Titus, L, Toland, AE, Torres, D, Trabert, B, Travis, R, Tung, N, Tworoger, SS, Valen, E, van Altena, AM, van der Hout, AH, Van Nieuwenhuysen, E, van Rensburg, EJ, Vega, A, Edwards, DV, Vierkant, RA, Wang, F, Wappenschmidt, B, Webb, PM, Weinberg, CR, Weitzel, JN, Wentzensen, N, White, E, Whittemore, AS, Winham, SJ, Wolk, A, Woo, YL, Wu, AH, Yan, L, Yannoukakos, D, Zavaglia, KM, Zheng, W, Ziogas, A, Zorn, KK, Kleibl, Z, Easton, D, Lawrenson, K, DeFazio, A, Sellers, TA, Ramus, SJ, Pearce, CL, Monteiro, AN, Cunningham, J, Goode, EL, Schildkraut, JM, Berchuck, A, Chenevix-Trench, G, Gayther, SA, Antoniou, AC, Pharoah, PDP. Eur J Hum Genet - 30 (3) : 349-362 (PMID: 35027648) (doi:10.1038/s41431-021-00987-7)
28 Feb | 2022 Considerations on diagnosis and surveillance measures of PTEN hamartoma tumor syndrome: clinical and genetic study in a series of Spanish patients. Pena-Couso, L, Ercibengoa, M, Mercadillo, F, Gómez-Sánchez, D, Inglada-Pérez, L, Santos, M, Lanillos, J, Gutiérrez-Abad, D, Hernández, A, Carbonell, P, Letón, R, Robledo, M, Rodríguez-Antona, C , Perea, J, Urioste, M, , . Orphanet J Rare Dis - 17 (1) : 85 (PMID: 35227301) (doi:10.1186/s13023-021-02079-7)
21 Feb | 2022 Clinical Pharmacogenetics Implementation Consortium Guideline for the Use of Aminoglycosides Based on MT-RNR1 Genotype. McDermott, JH, Wolf, J, Hoshitsuki, K, Huddart, R, Caudle, KE, Whirl-Carrillo, M, Steyger, PS, Smith, RJH, Cody, N, Rodriguez-Antona, C , Klein, TE, Newman, WG. Clin Pharmacol Ther - 111 (2) : 366-372 (PMID: 34032273) (doi:10.1002/cpt.2309)
18 Feb | 2022 Clinical pharmacogenetic analysis in 5,001 individuals with diagnostic Exome Sequencing data. Lanillos, J, Carcajona, M, Maietta, P, Alvarez, S, Rodriguez-Antona, C . NPJ Genom Med - 7 (1) : 12 (PMID: 35181665) (doi:10.1038/s41525-022-00283-3)
1 Nov | 2021 Sunitinib and Evofosfamide (TH-302) in Systemic Treatment-Naïve Patients with Grade 1/2 Metastatic Pancreatic Neuroendocrine Tumors: The GETNE-1408 Trial. Grande, E, Rodriguez-Antona, C , López, C, Alonso-Gordoa, T, Benavent, M, Capdevila, J, Teulé, A, Custodio, A, Sevilla, I , Hernando, J, Gajate, P, Molina-Cerrillo, J, Díez, JJ, Santos, M, Lanillos, J, García-Carbonero, R. Oncologist - 26 (11) : 941-949 (PMID: 34190375) (doi:10.1002/onco.13885)
23 Sep | 2021 Analysis of Telomere Maintenance Related Genes Reveals NOP10 as a New Metastatic-Risk Marker in Pheochromocytoma/Paraganglioma. Monteagudo, M, Martínez, P, Leandro-García, LJ, Martínez-Montes, ÁM, Calsina, B, Pulgarín-Alfaro, M, Díaz-Talavera, A, Mellid, S, Letón, R, Gil, E, Pérez-Martínez, M, Megías, D, Torres-Ruiz, R, Rodriguez-Perales, S, González, P, Caleiras, E, Jiménez-Villa, S, Roncador, G, Álvarez-Escolá, C, Regojo, RM, Calatayud, M, Guadalix, S, Currás-Freixes, M, Rapizzi, E, Canu, L, Nölting, S, Remde, H, Fassnacht, M, Bechmann, N, Eisenhofer, G, Mannelli, M, Beuschlein, F, Quinkler, M, Rodríguez-Antona, C , Cascón, A, Blasco, MA, Montero-Conde, C , Robledo, M. Cancers (Basel) - 13 (19) (PMID: 34638246) (doi:10.3390/cancers13194758)
21 Jun | 2021 MicroRNAs Targeting HIF-2α, VEGFR1 and/or VEGFR2 as Potential Predictive Biomarkers for VEGFR Tyrosine Kinase and HIF-2α Inhibitors in Metastatic Clear-Cell Renal Cell Carcinoma. Kinget, L, Roussel, E, Verbiest, A, Albersen, M, Rodríguez-Antona, C , Graña-Castro, O, Inglada-Pérez, L, Zucman-Rossi, J, Couchy, G, Job, S, de Reyniès, A, Laenen, A, Baldewijns, M, Beuselinck, B. Cancers (Basel) - 13 (12) (PMID: 34205829) (doi:10.3390/cancers13123099)
7 Jun | 2021 Circulating Levels of the Interferon-γ-Regulated Chemokines CXCL10/CXCL11, IL-6 and HGF Predict Outcome in Metastatic Renal Cell Carcinoma Patients Treated with Antiangiogenic Therapy. Esteban, E, Exposito, F, Crespo, G, Lambea, J, Pinto, A, Puente, J, Arranz, JA, Redrado, M, Rodriguez-Antona, C , de Andrea, C, Lopez-Brea, M, Redin, E, Rodriguez, A, Serrano, D, Garcia, J, Grande, E, Castellano, D, Calvo, A. Cancers (Basel) - 13 (11) (PMID: 34200459) (doi:10.3390/cancers13112849)
1 Apr | 2021 Prevalence of pathogenic germline variants in patients with metastatic renal cell carcinoma. Santos, M, Lanillos, J, Roldan-Romero, JM, Caleiras, E, Montero-Conde, C , Cascón, A, Climent, MA, Anguera, G, Hernando, S, Laínez, N, Robledo, M, Robles, L, de Velasco, G, García-Donas, J, Rodriguez-Antona, C . Genet Med - 23 (4) : 698-704 (PMID: 33442023) (doi:10.1038/s41436-020-01062-0)
28 Mar | 2021 MicroRNAs Possibly Involved in the Development of Bone Metastasis in Clear-Cell Renal Cell Carcinoma. Kinget, L, Roussel, E, Lambrechts, D, Boeckx, B, Vanginderhuysen, L, Albersen, M, Rodríguez-Antona, C , Graña-Castro, O, Inglada-Pérez, L, Verbiest, A, Zucman-Rossi, J, Couchy, G, Caruso, S, Laenen, A, Baldewijns, M, Beuselinck, B. Cancers (Basel) - 13 (7) (PMID: 33800656) (doi:10.3390/cancers13071554)
1 Dec | 2020 Molecular characterization of chromophobe renal cell carcinoma reveals mTOR pathway alterations in patients with poor outcome. Roldan-Romero, JM, Santos, M, Lanillos, J, Caleiras, E, Anguera, G, Maroto, P, García-Donas, J, de Velasco, G, Martinez-Montes, ÁM, Calsina, B, Monteagudo, M, Letón, R, Leandro-García, LJ, Montero-Conde, C , Cascón, A, Robledo, M, Rodriguez-Antona, C . Mod Pathol - 33 (12) : 2580-2590 (PMID: 32616874) (doi:10.1038/s41379-020-0607-z)
1 Dec | 2020 Overexpression of miR-483-5p is confined to metastases and linked to high circulating levels in patients with metastatic pheochromocytoma/paraganglioma. Castro-Vega, LJ, Calsina, B, Burnichon, N, Drossart, T, Martínez-Montes, ÁM, Verkarre, V, Amar, L, Bertherat, J, Rodríguez-Antona, C , Favier, J, Robledo, M, Gimenez-Roqueplo, AP. Clin Transl Med - 10 (8) : e260 (PMID: 33377638) (doi:10.1002/ctm2.260)
13 Nov | 2020 The need of the clinical implementation of pharmacogenetics in European health services for routine drug prescription. What's next? An urgent clinical unmet need for patients. Taron, M, Llerena, A, Manolopoulos, VG, Rodriguez-Antona, C , Stankovic, S, van Schaik, RHN. Drug Metab Pers Ther (PMID: 33185569) (doi:10.1515/dmdi-2020-0172)
13 Nov | 2020 The need of the clinical implementation of pharmacogenetics in European health services for routine drug prescription. What's next? An urgent clinical unmet need for patients. Taron, M, Llerena, A, Manolopoulos, VG, Rodriguez-Antona, C , Stankovic, S, van Schaik, RHN. Drug Metab Pers Ther - 35 (4) (PMID: 34704693) (doi:10.1515/dmpt-2020-0172)
9 Nov | 2020 Novel DNMT3A Germline Variant in a Patient with Multiple Paragangliomas and Papillary Thyroid Carcinoma. Mellid, S, Coloma, J, Calsina, B, Monteagudo, M, Roldán-Romero, JM, Santos, M, Leandro-García, LJ, Lanillos, J, Martínez-Montes, ÁM, Rodríguez-Antona, C , Montero-Conde, C , Martínez-López, J, Ayala, R, Matias-Guiu, X, Robledo, M, Cascón, A. Cancers (Basel) - 12 (11) (PMID: 33182397) (doi:10.3390/cancers12113304)
1 Nov | 2020 CD133 Expression in Medullary Thyroid Cancer Cells Identifies Patients with Poor Prognosis. Cordero-Barreal, A , Caleiras, E, López de Maturana, E, Monteagudo, M, Martínez-Montes, ÁM, Letón, R, Gil, E, Álvarez-Escolá, C, Regojo, RM, Andía, V, Marazuela, M, Guadalix, S, Calatayud, M, Robles-Díaz, L, Aguirre, M, Cano, JM, Díaz, JÁ, Saavedra, P, Lamas, C, Azriel, S, Sastre, J, Aller, J, Leandro-García, LJ, Calsina, B, Roldán-Romero, JM, Santos, M, Lanillos, J, Cascón, A, Rodríguez-Antona, C , Robledo, M, Montero-Conde, C . J Clin Endocrinol Metab - 105 (11) (PMID: 32791518) (doi:10.1210/clinem/dgaa527)
15 Oct | 2020 Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE). Talhouk, A, George, J, Wang, C, Budden, T, Tan, TZ, Chiu, DS, Kommoss, S, Leong, HS, Chen, S, Intermaggio, MP, Gilks, B, Nazeran, TM, Volchek, M, Elatre, W, Bentley, RC, Senz, J, Lum, A, Chow, V, Sudderuddin, H, Mackenzie, R, Leong, SCY, Liu, G, Johnson, D, Chen, B, Group, A, Alsop, J, Banerjee, SN, Behrens, S, Bodelon, C, Brand, AH, Brinton, L, Carney, ME, Chiew, YE, Cushing-Haugen, KL, Cybulski, C, Ennis, D, Fereday, S, Fortner, RT, García-Donas, J, Gentry-Maharaj, A, Glasspool, R, Goranova, T, Greene, CS, Haluska, P, Harris, HR, Hendley, J, Hernandez, BY, Herpel, E, Jimenez-Linan, M, Karpinskyj, C, Kaufmann, SH, Keeney, GL, Kennedy, CJ, Köbel, M, Koziak, JM, Larson, MC, Lester, J, Lewsley, LA, Lissowska, J, Lubiński, J, Luk, H, Macintyre, G, Mahner, S, McNeish, IA, Menkiszak, J, Nevins, N, Osorio, A, Oszurek, O, Palacios, J, Hinsley, S, Pearce, CL, Pike, MC, Piskorz, AM, Ray-Coquard, I, Rhenius, V, Rodriguez-Antona, C , Sharma, R, Sherman, ME, De Silva, D, Singh, N, Sinn, P, Slamon, D, Song, H, Steed, H, Stronach, EA, Thompson, PJ, Tołoczko, A, Trabert, B, Traficante, N, Tseng, CC, Widschwendter, M, Wilkens, LR, Winham, SJ, Winterhoff, B, Beeghly-Fadiel, A, Benitez, J, Berchuck, A, Brenton, JD, Brown, R, Chang-Claude, J, Chenevix-Trench, G, deFazio, A, Fasching, PA, García, MJ , Gayther, SA, Goodman, MT, Gronwald, J, Henderson, MJ, Karlan, BY, Kelemen, LE, Menon, U, Orsulic, S, Pharoah, PDP, Wentzensen, N, Wu, AH, Schildkraut, JM, Rossing, MA, Konecny, GE, Huntsman, DG, Huang, RY, Goode, EL, Ramus, SJ, Doherty, JA, Bowtell, DD, Anglesio, MS. Clin Cancer Res - 26 (20) : 5411-5423 (PMID: 32554541) (doi:10.1158/1078-0432.CCR-20-0103)
11 Sep | 2020 MicroRNA expression profiles in molecular subtypes of clear-cell renal cell carcinoma are associated with clinical outcome and repression of specific mRNA targets. Verbiest, A, Van Hoef, V, Rodriguez-Antona, C , García-Donas, J, Graña-Castro, O, Albersen, M, Baldewijns, M, Laenen, A, Roussel, E, Schöffski, P, Wozniak, A, Caruso, S, Couchy, G, Zucman-Rossi, J, Beuselinck, B. PLoS One - 15 (9) : e0238809 (PMID: 32915890) (doi:10.1371/journal.pone.0238809)
1 Sep | 2020 Clinical and pathological associations of PTEN expression in ovarian cancer: a multicentre study from the Ovarian Tumour Tissue Analysis Consortium. Martins, FC, Couturier, DL, Paterson, A, Karnezis, AN, Chow, C, Nazeran, TM, Odunsi, A, Gentry-Maharaj, A, Vrvilo, A, Hein, A, Talhouk, A, Osorio, A, Hartkopf, AD, Brooks-Wilson, A, DeFazio, A, Fischer, A, Hartmann, A, Hernandez, BY, McCauley, BM, Karpinskyj, C, de Sousa, CB, Høgdall, C, Tiezzi, DG, Herpel, E, Taran, FA, Modugno, F, Keeney, G, Nelson, G, Steed, H, Song, H, Luk, H, Benitez, J, Alsop, J, Koziak, JM, Lester, J, Rothstein, JH, de Andrade, JM, Lundvall, L, Paz-Ares, L, Robles-Díaz, L, Wilkens, LR, Garcia, MJ , Intermaggio, MP, Alcaraz, ML, Brett, MA, Beckmann, MW, Jimenez-Linan, M, Anglesio, M, Carney, ME, Schneider, M, Traficante, N, Pejovic, N, Singh, N, Le, N, Sinn, P, Ghatage, P, Erber, R, Edwards, R, Vierkant, R, Ness, RB, Leung, S, Orsulic, S, Brucker, SY, Kaufmann, SH, Fereday, S, Gayther, S, Winham, SJ, Kommoss, S, Pejovic, T, Longacre, TA, McGuire, V, Rhenius, V, Sieh, W, Shvetsov, YB, Whittemore, AS, Staebler, A, Karlan, BY, Rodriguez-Antona, C , Bowtell, DD, Goode, EL, Høgdall, E, Candido Dos Reis, FJ, Gronwald, J, Chang-Claude, J, Moysich, KB, Kelemen, LE, Cook, LS, Goodman, MT, Fasching, PA, Crawford, R, Deen, S, Menon, U, Huntsman, DG, Köbel, M, Ramus, SJ, Pharoah, PDP, Brenton, JD. Br J Cancer - 123 (5) : 793-802 (PMID: 32555365) (doi:10.1038/s41416-020-0900-0)
1 Sep | 2020 Genetic association of gemcitabine/carboplatin-induced leukopenia and neutropenia in non-small cell lung cancer patients using whole-exome sequencing. Svedberg, A, Björn, N, Sigurgeirsson, B, Pradhananga, S, Brandén, E, Koyi, H, Lewensohn, R, De Petris, L, Apellániz-Ruiz, M, Rodríguez-Antona, C , Lundeberg, J, Gréen, H. Lung Cancer - 147 : 106-114 (PMID: 32683206) (doi:10.1016/j.lungcan.2020.07.005)
1 Sep | 2020 P-Glycoprotein Inhibition Exacerbates Paclitaxel Neurotoxicity in Neurons and Patients With Cancer. Stage, TB, Mortensen, C, Khalaf, S, Steffensen, V, Hammer, HS, Xiong, C, Nielsen, F, Poetz, O, Svenningsen, ÅF, Rodriguez-Antona, C , Kroetz, DL. Clin Pharmacol Ther - 108 (3) : 671-680 (PMID: 32275773) (doi:10.1002/cpt.1847)
2 Jul | 2020 A Novel Approach for the Identification of Pharmacogenetic Variants in MT-RNR1 through Next-Generation Sequencing Off-Target Data. Lanillos, J, Santos, M, Carcajona, M, Roldan-Romero, JM, Martinez, AM, Calsina, B, Monteagudo, M, Leandro-García, LJ, Montero-Conde, C , Cascón, A, Maietta, P, Alvarez, S, Robledo, M, Rodriguez-Antona, C . J Clin Med - 9 (7) (PMID: 32630724) (doi:10.3390/jcm9072082)
1 Jul | 2020 MicroRNAs as potential predictors of extreme response to tyrosine kinase inhibitors in renal cell cancer. Garrigós, C, Molina-Pinelo, S, Meléndez, R, Espinosa, M, Lerma, A, Taron, M, García-Donas, J, Rodriguez-Antona, C , Duran, I. Urol Oncol - 38 (7) : 640.e23-640.e29 (PMID: 32081561) (doi:10.1016/j.urolonc.2020.01.012)
22 Apr | 2020 Effect of the Most Relevant CYP3A4 and CYP3A5 Polymorphisms on the Pharmacokinetic Parameters of 10 CYP3A Substrates. Saiz-Rodríguez, M, Almenara, S, Navares-Gómez, M, Ochoa, D, Román, M, Zubiaur, P, Koller, D, Santos, M, Mejía, G, Borobia, AM, Rodríguez-Antona, C , Abad-Santos, F. Biomedicines - 8 (4) (PMID: 32331352) (doi:10.3390/biomedicines8040094)
1 Apr | 2020 Genes and variants in hematopoiesis-related pathways are associated with gemcitabine/carboplatin-induced thrombocytopenia. Björn, N, Sigurgeirsson, B, Svedberg, A, Pradhananga, S, Brandén, E, Koyi, H, Lewensohn, R, de Petris, L, Apellániz-Ruiz, M, Rodríguez-Antona, C , Lundeberg, J, Gréen, H. Pharmacogenomics J - 20 (2) : 179-191 (PMID: 31616045) (doi:10.1038/s41397-019-0099-8)
1 Mar | 2020 PTEN expression and mutations in TSC1, TSC2 and MTOR are associated with response to rapalogs in patients with renal cell carcinoma. Roldan-Romero, JM, Beuselinck, B, Santos, M, Rodriguez-Moreno, JF, Lanillos, J, Calsina, B, Gutierrez, A, Tang, K, Lainez, N, Puente, J, Castellano, D, Esteban, E, Climent, MA, Arranz, JA, Albersen, M, Oudard, S, Couchy, G, Caleiras, E, Montero-Conde, C , Cascón, A, Robledo, M, Rodríguez-Antona, C , García-Donas, J, , . Int J Cancer - 146 (5) : 1435-1444 (PMID: 31335987) (doi:10.1002/ijc.32579)
15 Jan | 2020 Hsa-miR-139-5p is a prognostic thyroid cancer marker involved in HNRNPF-mediated alternative splicing. Montero-Conde, C , Graña-Castro, O, Martín-Serrano, G, Martínez-Montes, ÁM, Zarzuela, E, Muñoz, J, Torres-Perez, R, Pita, G, Cordero-Barreal, A , Leandro-García, LJ, Letón, R, López de Silanes, I, Guadalix, S, Pérez-Barrios, A, Hawkins, F, Guerrero-Álvarez, A, Álvarez-Escolá, C, Regojo-Zapata, RM, Calsina, B, Remacha, L, Roldán-Romero, JM, Santos, M, Lanillos, J, Jordá, M, Riesco-Eizaguirre, G , Zafon, C, González-Neira, A, Blasco, MA, Al-Shahrour, F, Rodríguez-Antona, C , Cascón, A, Robledo, M. Int J Cancer - 146 (2) : 521-530 (PMID: 31403184) (doi:10.1002/ijc.32622)
19 Dec | 2019 Prognostic and Predictive Value of PBRM1 in Clear Cell Renal Cell Carcinoma. Carril-Ajuria, L, Santos, M, Roldán-Romero, JM, Rodriguez-Antona, C , de Velasco, G. Cancers (Basel) - 12 (1) (PMID: 31861590) (doi:10.3390/cancers12010016)
1 Nov | 2019 A Pilot, Phase II, Randomized, Open-Label Clinical Trial Comparing the Neurotoxicity of Three Dose Regimens of Nab-Paclitaxel to That of Solvent-Based Paclitaxel as the First-Line Treatment for Patients with Human Epidermal Growth Factor Receptor Type 2-Negative Metastatic Breast Cancer. Ciruelos, E, Apellániz-Ruiz, M, Cantos, B, Martinez-Jáñez, N, Bueno-Muiño, C, Echarri, MJ, Enrech, S, Guerra, JA, Manso, L, Pascual, T, Dominguez, C, Gonzalo, JF, Sanz, JL, Rodriguez-Antona, C , Sepúlveda, JM. Oncologist - 24 (11) : e1024-e1033 (PMID: 31023863) (doi:10.1634/theoncologist.2017-0664)
1 Aug | 2019 Concomitant Medications and Risk of Chemotherapy-Induced Peripheral Neuropathy. Sánchez-Barroso, L, Apellaniz-Ruiz, M, Gutiérrez-Gutiérrez, G, Santos, M, Roldán-Romero, JM, Curras, M, Remacha, L, Calsina, B, Calvo, I, Sereno, M, Merino, M, García-Donas, J, Castelo, B, Guerra, E, Letón, R, Montero-Conde, C , Cascón, A, Inglada-Pérez, L, Robledo, M, Rodríguez-Antona, C . Oncologist - 24 (8) : e784-e792 (PMID: 30470691) (doi:10.1634/theoncologist.2018-0418)
9 Jul | 2019 Integrative multi-omics analysis identifies a prognostic miRNA signature and a targetable miR-21-3p/TSC2/mTOR axis in metastatic pheochromocytoma/paraganglioma. Calsina, B, Castro-Vega, LJ, Torres-Pérez, R, Inglada-Pérez, L, Currás-Freixes, M, Roldán-Romero, JM, Mancikova, V, Letón, R, Remacha, L, Santos, M, Burnichon, N, Lussey-Lepoutre, C, Rapizzi, E, Graña, O, Álvarez-Escolá, C, de Cubas, AA, Lanillos, J, Cordero-Barreal, A , Martínez-Montes, ÁM, Bellucci, A, Amar, L, Fernandes-Rosa, FL, Calatayud, M, Aller, J, Lamas, C, Sastre-Marcos, J, Canu, L, Korpershoek, E, Timmers, HJ, Lenders, JW, Beuschlein, F, Fassnacht-Capeller, M, Eisenhofer, G, Mannelli, M, Al-Shahrour, F, Favier, J, Rodríguez-Antona, C , Cascón, A, Montero-Conde, C , Gimenez-Roqueplo, AP, Robledo, M. Theranostics - 9 (17) : 4946-4958 (PMID: 31410193) (doi:10.7150/thno.35458)
2 May | 2019 Recurrent Germline DLST Mutations in Individuals with Multiple Pheochromocytomas and Paragangliomas. Remacha, L, Pirman, D, Mahoney, CE, Coloma, J, Calsina, B, Currás-Freixes, M, Letón, R, Torres-Pérez, R, Richter, S, Pita, G, Herráez, B, Cianchetta, G, Honrado, E, Maestre, L, Urioste, M, Aller, J, García-Uriarte, Ó, Gálvez, MÁ, Luque, RM, Lahera, M, Moreno-Rengel, C, Eisenhofer, G, Montero-Conde, C , Rodríguez-Antona, C , Llorca, Ó, Smolen, GA, Robledo, M, Cascón, A. Am J Hum Genet - 104 (5) : 1008-1010 (PMID: 31051110) (doi:10.1016/j.ajhg.2019.04.010)
4 Apr | 2019 Recurrent Germline DLST Mutations in Individuals with Multiple Pheochromocytomas and Paragangliomas. Remacha, L, Pirman, D, Mahoney, CE, Coloma, J, Calsina, B, Currás-Freixes, M, Letón, R, Torres-Pérez, R, Richter, S, Pita, G, Herráez, B, Cianchetta, G, Honrado, E, Maestre, L, Urioste, M, Aller, J, García-Uriarte, Ó, Gálvez, MÁ, Luque, RM, Lahera, M, Moreno-Rengel, C, Eisenhofer, G, Montero-Conde, C , Rodríguez-Antona, C , Llorca, Ó, Smolen, GA, Robledo, M, Cascón, A. Am J Hum Genet - 104 (4) : 651-664 (PMID: 30929736) (doi:10.1016/j.ajhg.2019.02.017)
1 Feb | 2019 Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk. Yang, Y, Wu, L, Shu, X, Lu, Y, Shu, XO, Cai, Q, Beeghly-Fadiel, A, Li, B, Ye, F, Berchuck, A, Anton-Culver, H, Banerjee, S, Benitez, J, Bjørge, L, Brenton, JD, Butzow, R, Campbell, IG, Chang-Claude, J, Chen, K, Cook, LS, Cramer, DW, deFazio, A, Dennis, J, Doherty, JA, Dörk, T, Eccles, DM, Edwards, DV, Fasching, PA, Fortner, RT, Gayther, SA, Giles, GG, Glasspool, RM, Goode, EL, Goodman, MT, Gronwald, J, Harris, HR, Heitz, F, Hildebrandt, MA, Høgdall, E, Høgdall, CK, Huntsman, DG, Kar, SP, Karlan, BY, Kelemen, LE, Kiemeney, LA, Kjaer, SK, Koushik, A, Lambrechts, D, Le, ND, Levine, DA, Massuger, LF, Matsuo, K, May, T, McNeish, IA, Menon, U, Modugno, F, Monteiro, AN, Moorman, PG, Moysich, KB, Ness, RB, Nevanlinna, H, Olsson, H, Onland-Moret, NC, Park, SK, Paul, J, Pearce, CL, Pejovic, T, Phelan, CM, Pike, MC, Ramus, SJ, Riboli, E, Rodriguez-Antona, C , Romieu, I, Sandler, DP, Schildkraut, JM, Setiawan, VW, Shan, K, Siddiqui, N, Sieh, W, Stampfer, MJ, Sutphen, R, Swerdlow, AJ, Szafron, LM, Teo, SH, Tworoger, SS, Tyrer, JP, Webb, PM, Wentzensen, N, White, E, Willett, WC, Wolk, A, Woo, YL, Wu, AH, Yan, L, Yannoukakos, D, Chenevix-Trench, G, Sellers, TA, Pharoah, PDP, Zheng, W, Long, J. Cancer Res - 79 (3) : 505-517 (PMID: 30559148) (doi:10.1158/0008-5472.CAN-18-2726)
1 Dec | 2018 Gain-of-function mutations in DNMT3A in patients with paraganglioma. Remacha, L, Currás-Freixes, M, Torres-Ruiz, R, Schiavi, F, Torres-Pérez, R, Calsina, B, Letón, R, Comino-Méndez, I, Roldán-Romero, JM, Montero-Conde, C , Santos, M, Pérez, LI, Pita, G, Alonso, MR, Honrado, E, Pedrinaci, S, Crespo-Facorro, B, Percesepe, A, Falcioni, M, Rodríguez-Perales, S, Korpershoek, E, Ramón-Maiques, S, Opocher, G, Rodríguez-Antona, C , Robledo, M, Cascón, A. Genet Med - 20 (12) : 1644-1651 (PMID: 29740169) (doi:10.1038/s41436-018-0003-y)
1 Dec | 2018 Role of MDH2 pathogenic variant in pheochromocytoma and paraganglioma patients. Calsina, B, Currás-Freixes, M, Buffet, A, Pons, T, Contreras, L, Letón, R, Comino-Méndez, I, Remacha, L, Calatayud, M, Obispo, B, Martin, A, Cohen, R, Richter, S, Balmaña, J, Korpershoek, E, Rapizzi, E, Deutschbein, T, Vroonen, L, Favier, J, de Krijger, RR, Fassnacht, M, Beuschlein, F, Timmers, HJ, Eisenhofer, G, Mannelli, M, Pacak, K, Satrústegui, J, Rodríguez-Antona, C , Amar, L, Cascón, A, Dölker, N, Gimenez-Roqueplo, AP, Robledo, M. Genet Med - 20 (12) : 1652-1662 (PMID: 30008476) (doi:10.1038/s41436-018-0068-7)
20 Nov | 2018 Prognostic and predictive biomarkers for somatostatin analogs, peptide receptor radionuclide therapy and serotonin pathway targets in neuroendocrine tumours. Barriuso, J, Custodio, A, Afonso, R, Alonso, V, Astudillo, A, Capdevila, J, García-Carbonero, R, Grande, E, Jimenez-Fonseca, P, Marazuela, M, Rodríguez-Antona, C , Aller, J. Cancer Treat Rev - 70 : 209-222 (PMID: 30292979) (doi:10.1016/j.ctrv.2018.09.008)
15 Sep | 2018 A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk. Lu, Y, Beeghly-Fadiel, A, Wu, L, Guo, X, Li, B, Schildkraut, JM, Im, HK, Chen, YA, Permuth, JB, Reid, BM, Teer, JK, Moysich, KB, Andrulis, IL, Anton-Culver, H, Arun, BK, Bandera, EV, Barkardottir, RB, Barnes, DR, Benitez, J, Bjorge, L, Brenton, J, Butzow, R, Caldes, T, Caligo, MA, Campbell, I, Chang-Claude, J, Claes, KBM, Couch, FJ, Cramer, DW, Daly, MB, deFazio, A, Dennis, J, Diez, O, Domchek, SM, Dörk, T, Easton, DF, Eccles, DM, Fasching, PA, Fortner, RT, Fountzilas, G, Friedman, E, Ganz, PA, Garber, J, Giles, GG, Godwin, AK, Goldgar, DE, Goodman, MT, Greene, MH, Gronwald, J, Hamann, U, Heitz, F, Hildebrandt, MAT, Høgdall, CK, Hollestelle, A, Hulick, PJ, Huntsman, DG, Imyanitov, EN, Isaacs, C, Jakubowska, A, James, P, Karlan, BY, Kelemen, LE, Kiemeney, LA, Kjaer, SK, Kwong, A, Le, ND, Leslie, G, Lesueur, F, Levine, DA, Mattiello, A, May, T, McGuffog, L, McNeish, IA, Merritt, MA, Modugno, F, Montagna, M, Neuhausen, SL, Nevanlinna, H, Nielsen, FC, Nikitina-Zake, L, Nussbaum, RL, Offit, K, Olah, E, Olopade, OI, Olson, SH, Olsson, H, Osorio, A, Park, SK, Parsons, MT, Peeters, PHM, Pejovic, T, Peterlongo, P, Phelan, CM, Pujana, MA, Ramus, SJ, Rennert, G, Risch, H, Rodriguez, GC, Rodríguez-Antona, C , Romieu, I, Rookus, MA, Rossing, MA, Rzepecka, IK, Sandler, DP, Schmutzler, RK, Setiawan, VW, Sharma, P, Sieh, W, Simard, J, Singer, CF, Song, H, Southey, MC, Spurdle, AB, Sutphen, R, Swerdlow, AJ, Teixeira, MR, Teo, SH, Thomassen, M, Tischkowitz, M, Toland, AE, Trichopoulou, A, Tung, N, Tworoger, SS, van Rensburg, EJ, Vanderstichele, A, Vega, A, Edwards, DV, Webb, PM, Weitzel, JN, Wentzensen, N, White, E, Wolk, A, Wu, AH, Yannoukakos, D, Zorn, KK, Gayther, SA, Antoniou, AC, Berchuck, A, Goode, EL, Chenevix-Trench, G, Sellers, TA, Pharoah, PDP, Zheng, W, Long, J. Cancer Res - 78 (18) : 5419-5430 (PMID: 30054336) (doi:10.1158/0008-5472.CAN-18-0951)
1 Jun | 2018 Novel copy-number variations in pharmacogenes contribute to interindividual differences in drug pharmacokinetics. Santos, M, Niemi, M, Hiratsuka, M, Kumondai, M, Ingelman-Sundberg, M, Lauschke, VM, Rodríguez-Antona, C . Genet Med - 20 (6) : 622-629 (PMID: 29261188) (doi:10.1038/gim.2017.156)
15 May | 2018 A Genetic Polymorphism in CTLA-4 Is Associated with Overall Survival in Sunitinib-Treated Patients with Clear Cell Metastatic Renal Cell Carcinoma. Liu, X, Swen, JJ, Diekstra, MHM, Boven, E, Castellano, D, Gelderblom, H, Mathijssen, RHJ, Vermeulen, SH, Oosterwijk, E, Junker, K, Roessler, M, Alexiusdottir, K, Sverrisdottir, A, Radu, MT, Ambert, V, Eisen, T, Warren, A, Rodríguez-Antona, C , García-Donas, J, Böhringer, S, Koudijs, KKM, Kiemeney, LALM, Rini, BI, Guchelaar, HJ. Clin Cancer Res - 24 (10) : 2350-2356 (PMID: 29490989) (doi:10.1158/1078-0432.CCR-17-2815)
15 May | 2018 Advanced sporadic renal epithelioid angiomyolipoma: case report of an extraordinary response to sirolimus linked to TSC2 mutation. Espinosa, M, Roldán-Romero, JM, Duran, I, de Álava, E, Apellaniz-Ruiz, M, Cascón, A, Garrigos, C, Robledo, M, Rodriguez-Antona, C . BMC Cancer - 18 (1) : 561 (PMID: 29764404) (doi:10.1186/s12885-018-4467-6)
1 Apr | 2018 Biallelic TSC2 Mutations in a Patient With Chromophobe Renal Cell Carcinoma Showing Extraordinary Response to Temsirolimus. Maroto, P, Anguera, G, Roldan-Romero, JM, Apellániz-Ruiz, M, Algaba, F, Boonman, J, Nellist, M, Montero-Conde, C , Cascón, A, Robledo, M, Rodríguez-Antona, C . J Natl Compr Canc Netw - 16 (4) : 352-358 (PMID: 29632054) (doi:10.6004/jnccn.2017.7041)
1 Feb | 2018 Influence of donor liver CYP3A4*20 loss-of-function genotype on tacrolimus pharmacokinetics in transplanted patients. Gómez-Bravo, MA, Apellaniz-Ruiz, M, Salcedo, M, Fondevila, C, Suarez, F, Castellote, J, Rufian, S, Pons, JA, Bilbao, I, Alamo, JM, Millán, O , Brunet, M, Rodríguez-Antona, C . Pharmacogenet Genomics - 28 (2) : 41-48 (PMID: 29256966) (doi:10.1097/FPC.0000000000000321)
1 Dec | 2017 Association between SLC19A1 Gene Polymorphism and High Dose Methotrexate Toxicity in Childhood Acute Lymphoblastic Leukaemia and Non Hodgkin Malignant Lymphoma: Introducing a Haplotype based Approach. Kotnik, BF, Jazbec, J, Grabar, PB, Rodriguez-Antona, C , Dolzan, V. Radiol Oncol - 51 (4) : 455-462 (PMID: 29333125) (doi:10.1515/raon-2017-0040)
1 Nov | 2017 Exceptional Response to Temsirolimus in a Metastatic Clear Cell Renal Cell Carcinoma With an Early Novel MTOR-Activating Mutation. Rodríguez-Moreno, JF, Apellaniz-Ruiz, M, Roldan-Romero, JM, Durán, I, Beltrán, L, Montero-Conde, C , Cascón, A, Robledo, M, García-Donas, J, Rodríguez-Antona, C . J Natl Compr Canc Netw - 15 (11) : 1310-1315 (PMID: 29118224) (doi:10.6004/jnccn.2017.7018)
1 Oct | 2017 A Prospective Observational Study for Assessment and Outcome Association of Circulating Endothelial Cells in Clear Cell Renal Cell Carcinoma Patients Who Show Initial Benefit from First-line Treatment. The CIRCLES (CIRCuLating Endothelial cellS) Study (SOGUG-CEC-2011-01). García-Donas, J, Leon, LA, Esteban, E, Vidal-Mendez, MJ, Arranz, JA, Garcia Del Muro, X, Basterretxea, L, González Del Alba, A, Climent, MA, Virizuela, JA, Álvarez, C, Sepúlveda, J, Anido, U, López, C, Ortiz-Morales, MJ, Pérez, X, Rodriguez-Antona, C , Rodriguez-Moreno, JF, Hernando, S, Castellano, D. Eur Urol Focus - 3 (4-5) : 430-436 (PMID: 28753791) (doi:10.1016/j.euf.2016.09.004)
1 Sep | 2017 mTOR Pathway Mutations and Response to Rapalogs in RCC-Letter. Roldan-Romero, JM, Rodríguez-Moreno, JF, García-Donás, J, Rodríguez-Antona, C . Clin Cancer Res - 23 (17) : 5320 (PMID: 28864728) (doi:10.1158/1078-0432.CCR-17-1280)
1 Aug | 2017 Description of the EuroTARGET cohort: A European collaborative project on TArgeted therapy in renal cell cancer-GEnetic- and tumor-related biomarkers for response and toxicity. van der Zanden, LFM, Vermeulen, SH, Oskarsdottir, A, Maurits, JSF, Diekstra, MHM, Ambert, V, Cambon-Thomsen, A, Castellano, D, Fritsch, A, Garcia Donas, J, Guarch Troyas, R, Guchelaar, HJ, Hartmann, A, Hulsbergen-van de Kaa, C, Jaehde, U, Junker, K, Martinez-Cardus, A, Masson, G, Oosterwijk-Wakka, J, Radu, MT, Rafnar, T, Rodriguez-Antona, C , Roessler, M, Ruijtenbeek, R, Stefansson, K, Warren, A, Wessels, L, Eisen, T, Kiemeney, LALM, Oosterwijk, E. Urol Oncol - 35 (8) : 529.e9-529.e16 (PMID: 28385611) (doi:10.1016/j.urolonc.2017.03.009)
20 Jul | 2017 Polymorphisms associated with everolimus pharmacokinetics, toxicity and survival in metastatic breast cancer. Pascual, T, Apellániz-Ruiz, M, Pernaut, C, Cueto-Felgueroso, C, Villalba, P, Álvarez, C, Manso, L, Inglada-Pérez, L, Robledo, M, Rodríguez-Antona, C , Ciruelos, E. PLoS One - 12 (7) : e0180192 (PMID: 28727815) (doi:10.1371/journal.pone.0180192)
1 Jul | 2017 PheoSeq: A Targeted Next-Generation Sequencing Assay for Pheochromocytoma and Paraganglioma Diagnostics. Currás-Freixes, M, Piñeiro-Yañez, E, Montero-Conde, C , Apellániz-Ruiz, M, Calsina, B, Mancikova, V, Remacha, L, Richter, S, Ercolino, T, Rogowski-Lehmann, N, Deutschbein, T, Calatayud, M, Guadalix, S, Álvarez-Escolá, C, Lamas, C, Aller, J, Sastre-Marcos, J, Lázaro, C, Galofré, JC, Patiño-García, A, Meoro-Avilés, A, Balmaña-Gelpi, J, De Miguel-Novoa, P, Balbín, M, Matías-Guiu, X, Letón, R, Inglada-Pérez, L, Torres-Pérez, R, Roldán-Romero, JM, Rodríguez-Antona, C , Fliedner, SMJ, Opocher, G, Pacak, K, Korpershoek, E, de Krijger, RR, Vroonen, L, Mannelli, M, Fassnacht, M, Beuschlein, F, Eisenhofer, G, Cascón, A, Al-Shahrour, F, Robledo, M. J Mol Diagn - 19 (4) : 575-588 (PMID: 28552549) (doi:10.1016/j.jmoldx.2017.04.009)
1 Jun | 2017 Evaluation of KDR rs34231037 as a predictor of sunitinib efficacy in patients with metastatic renal cell carcinoma. Apellániz-Ruiz, M, Diekstra, MH, Roldán, JM, Boven, E, Castellano, D, Gelderblom, H, Mathijssen, RHJ, Swen, JJ, Böhringer, S, García-Donás, J, Rini, BI, Guchelaar, HJ, Rodríguez-Antona, C . Pharmacogenet Genomics - 27 (6) : 227-231 (PMID: 28430711) (doi:10.1097/FPC.0000000000000280)
1 May | 2017 Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer. 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1 Aug | 2013 Molecular markers to predict response to therapy. Garcia-Donas, J, Rodriguez-Antona, C , Jonasch, E. Semin Oncol - 40 (4) : 444-458 (PMID: 23972708) (doi:10.1053/j.seminoncol.2013.05.005)
1 Jun | 2013 Tumoral EPAS1 (HIF2A) mutations explain sporadic pheochromocytoma and paraganglioma in the absence of erythrocytosis. Comino-Méndez, I, de Cubas, AA, Bernal, C, Álvarez-Escolá, C, Sánchez-Malo, C, Ramírez-Tortosa, CL, Pedrinaci, S, Rapizzi, E, Ercolino, T, Bernini, G, Bacca, A, Letón, R, Pita, G, Alonso, MR, Leandro-García, LJ, Gómez-Graña, A, Inglada-Pérez, L, Mancikova, V, Rodríguez-Antona, C , Mannelli, M, Robledo, M, Cascón, A. Hum Mol Genet - 22 (11) : 2169-2176 (PMID: 23418310) (doi:10.1093/hmg/ddt069)
1 Feb | 2013 Differential gene expression of medullary thyroid carcinoma reveals specific markers associated with genetic conditions. Maliszewska, A, Leandro-Garcia, LJ, Castelblanco, E, Macià, A, de Cubas, A, Goméz-López, G, Inglada-Pérez, L, Álvarez-Escolá, C, De la Vega, L, Letón, R, Gómez-Graña, Á, Landa, I, Cascón, A, Rodríguez-Antona, C , Borrego, S, Zane, M, Schiavi, F, Merante-Boschin, I, Pelizzo, MR, Pisano, DG, Opocher, G, Matias-Guiu, X, Encinas, M, Robledo, M. Am J Pathol - 182 (2) : 350-362 (PMID: 23201134) (doi:10.1016/j.ajpath.2012.10.025)
1 Nov | 2012 Constitutional genetic variants as predictors of antiangiogenic therapy outcome in renal cell carcinoma. Rodríguez-Antona, C , García-Donas, J. Pharmacogenomics - 13 (14) : 1621-1633 (PMID: 23148638) (doi:10.2217/pgs.12.142)
1 Nov | 2012 Genetic variation in the SLC19A1 gene and methotrexate toxicity in rheumatoid arthritis patients. Bohanec Grabar, P, Leandro-García, LJ, Inglada-Pérez, L, Logar, D, Rodríguez-Antona, C , Dolžan, V. Pharmacogenomics - 13 (14) : 1583-1594 (PMID: 23148635) (doi:10.2217/pgs.12.150)
15 Sep | 2012 Hematologic β-tubulin VI isoform exhibits genetic variability that influences paclitaxel toxicity. Leandro-García, LJ, Leskelä, S, Inglada-Pérez, L, Landa, I, de Cubas, AA, Maliszewska, A, Comino-Méndez, I, Letón, R, Gómez-Graña, Á, Torres, R, Ramírez, JC, Álvarez, S, Rivera, J, Martínez, C, Lozano, ML, Cascón, A, Robledo, M, Rodríguez-Antona, C . Cancer Res - 72 (18) : 4744-4752 (PMID: 22805305) (doi:10.1158/0008-5472.CAN-11-2861)
10 Sep | 2012 Identification of candidate SNPs for drug induced toxicity from differentially expressed genes in associated tissues. Hasmats, J, Kupershmidt, I, Rodríguez-Antona, C , Su, QJ, Khan, MS, Jara, C, Mielgo, X, Lundeberg, J, Green, H. Gene - 506 (1) : 62-68 (PMID: 22759513) (doi:10.1016/j.gene.2012.06.053)
15 Aug | 2012 Regulatory polymorphisms in β-tubulin IIa are associated with paclitaxel-induced peripheral neuropathy. Leandro-García, LJ, Leskelä, S, Jara, C, Gréen, H, Avall-Lundqvist, E, Wheeler, HE, Dolan, ME, Inglada-Perez, L, Maliszewska, A, de Cubas, AA, Comino-Méndez, I, Mancikova, V, Cascón, A, Robledo, M, Rodríguez-Antona, C . Clin Cancer Res - 18 (16) : 4441-4448 (PMID: 22718863) (doi:10.1158/1078-0432.CCR-12-1221)
11 Jun | 2012 Deregulated miRNAs in hereditary breast cancer revealed a role for miR-30c in regulating KRAS oncogene. Tanic, M, Yanowsky, K, Rodriguez-Antona, C , Andrés, R, Márquez-Rodas, I, Osorio, A, Benitez, J, Martinez-Delgado, B. PLoS One - 7 (6) : e38847 (PMID: 22701724) (doi:10.1371/journal.pone.0038847)
1 Nov | 2011 Detection of the first gross CDC73 germline deletion in an HPT-JT syndrome family. Cascón, A, Huarte-Mendicoa, CV, Javier Leandro-García, L, Letón, R, Suela, J, Santana, A, Costa, MB, Comino-Méndez, I, Landa, I, Sánchez, L, Rodríguez-Antona, C , Cigudosa, JC, Robledo, M. Genes Chromosomes Cancer - 50 (11) : 922-929 (PMID: 21837707) (doi:10.1002/gcc.20911)
1 Nov | 2011 Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study. Garcia-Donas, J, Esteban, E, Leandro-García, LJ, Castellano, DE, González del Alba, A, Climent, MA, Arranz, JA, Gallardo, E, Puente, J, Bellmunt, J, Mellado, B, Martínez, E, Moreno, F, Font, A, Robledo, M, Rodríguez-Antona, C . Lancet Oncol - 12 (12) : 1143-1150 (PMID: 22015057) (doi:10.1016/S1470-2045(11)70266-2)
19 Jun | 2011 Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma. Comino-Méndez, I, Gracia-Aznárez, FJ, Schiavi, F, Landa, I, Leandro-García, LJ, Letón, R, Honrado, E, Ramos-Medina, R, Caronia, D, Pita, G, Gómez-Graña, A, de Cubas, AA, Inglada-Pérez, L, Maliszewska, A, Taschin, E, Bobisse, S, Pica, G, Loli, P, Hernández-Lavado, R, Díaz, JA, Gómez-Morales, M, González-Neira, A, Roncador, G, Rodríguez-Antona, C , Benítez, J, Mannelli, M, Opocher, G, Robledo, M, Cascón, A. Nat Genet - 43 (7) : 663-667 (PMID: 21685915) (doi:10.1038/ng.861)
1 Apr | 2011 Microtubule-targeting drugs and personalization of cancer treatment. Rodríguez-Antona, C , Gréen, H. Pharmacogenomics - 12 (4) : 449-451 (PMID: 21521015) (doi:10.2217/pgs.11.12)
1 Apr | 2011 Polymorphisms in cytochromes P450 2C8 and 3A5 are associated with paclitaxel neurotoxicity. Leskelä, S, Jara, C, Leandro-García, LJ, Martínez, A, García-Donas, J, Hernando, S, Hurtado, A, Vicario, JC, Montero-Conde, C, Landa, I, López-Jiménez, E, Cascón, A, Milne, RL, Robledo, M, Rodríguez-Antona, C . Pharmacogenomics J - 11 (2) : 121-129 (PMID: 20212519) (doi:10.1038/tpj.2010.13)
1 Feb | 2011 The miR-200 family controls beta-tubulin III expression and is associated with paclitaxel-based treatment response and progression-free survival in ovarian cancer patients. Leskelä, S, Leandro-García, LJ, Mendiola, M , Barriuso, J, Inglada-Pérez, L, Muñoz, I, Martínez-Delgado, B, Redondo, A, de Santiago, J, Robledo, M, Hardisson, D, Rodríguez-Antona, C . Endocr Relat Cancer - 18 (1) : 85-95 (PMID: 21051560) (doi:10.1677/ERC-10-0148)
1 Dec | 2010 Research resource: Transcriptional profiling reveals different pseudohypoxic signatures in SDHB and VHL-related pheochromocytomas. López-Jiménez, E, Gómez-López, G, Leandro-García, LJ, Muñoz, I, Schiavi, F, Montero-Conde, C , de Cubas, AA, Ramires, R, Landa, I, Leskelä, S, Maliszewska, A, Inglada-Pérez, L, de la Vega, L, Rodríguez-Antona, C , Letón, R, Bernal, C, de Campos, JM, Diez-Tascón, C, Fraga, MF, Boullosa, C, Pisano, DG, Opocher, G, Robledo, M, Cascón, A. Mol Endocrinol - 24 (12) : 2382-2391 (PMID: 20980436) (doi:10.1210/me.2010-0256)
1 Jun | 2010 Allelic variant at -79 (C>T) in CDKN1B (p27Kip1) confers an increased risk of thyroid cancer and alters mRNA levels. Landa, I, Montero-Conde, C , Malanga, D, De Gisi, S, Pita, G, Leandro-García, LJ, Inglada-Pérez, L, Letón, R, De Marco, C, Rodríguez-Antona, C , Viglietto, G, Robledo, M. Endocr Relat Cancer - 17 (2) : 317-328 (PMID: 20075119) (doi:10.1677/ERC-09-0016)
1 May | 2010 Pharmacogenomics of paclitaxel. Rodríguez-Antona, C . Pharmacogenomics - 11 (5) : 621-623 (PMID: 20415548) (doi:10.2217/pgs.10.32)
1 Apr | 2010 Tumoral and tissue-specific expression of the major human beta-tubulin isotypes. Leandro-García, LJ, Leskelä, S, Landa, I, Montero-Conde, C , López-Jiménez, E, Letón, R, Cascón, A, Robledo, M, Rodríguez-Antona, C . Cytoskeleton (Hoboken) - 67 (4) : 214-223 (PMID: 20191564) (doi:10.1002/cm.20436)
1 Mar | 2010 Overexpression and activation of EGFR and VEGFR2 in medullary thyroid carcinomas is related to metastasis. Rodríguez-Antona, C , Pallares, J, Montero-Conde, C , Inglada-Pérez, L, Castelblanco, E, Landa, I, Leskelä, S, Leandro-García, LJ, López-Jiménez, E, Letón, R, Cascón, A, Lerma, E, Martin, MC, Carralero, MC, Mauricio, D, Cigudosa, JC, Matias-Guiu, X, Robledo, M. Endocr Relat Cancer - 17 (1) : 7-16 (PMID: 19776290) (doi:10.1677/ERC-08-0304)
1 Jan | 2010 Molecular genetics and epigenetics of the cytochrome P450 gene family and its relevance for cancer risk and treatment. Rodriguez-Antona, C , Gomez, A, Karlgren, M, Sim, SC, Ingelman-Sundberg, M. Hum Genet - 127 (1) : 1-17 (PMID: 19823875) (doi:10.1007/s00439-009-0748-0)
16 Dec | 2009 The hematopoietic-specific beta1-tubulin is naturally resistant to 2-methoxyestradiol and protects patients from drug-induced myelosuppression. Escuin, D, Burke, PA, McMahon-Tobin, G, Hembrough, T, Wang, Y, Alcaraz, AA, Leandro-García, LJ, Rodríguez-Antona, C , Snyder, JP, Lavallee, TM, Giannakakou, P. Cell Cycle - 8 (23) : 3914-3924 (PMID: 19901556) (doi:10.4161/cc.8.23.10105)
4 Sep | 2009 The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. Landa, I, Ruiz-Llorente, S , Montero-Conde, C , Inglada-Pérez, L, Schiavi, F, Leskelä, S, Pita, G, Milne, R, Maravall, J, Ramos, I, Andía, V, Rodríguez-Poyo, P, Jara-Albarrán, A, Meoro, A, del Peso, C, Arribas, L, Iglesias, P, Caballero, J, Serrano, J, Picó, A, Pomares, F, Giménez, G, López-Mondéjar, P, Castello, R, Merante-Boschin, I, Pelizzo, MR, Mauricio, D, Opocher, G, Rodríguez-Antona, C , González-Neira, A, Matías-Guiu, X, Santisteban, P , Robledo, M. PLoS Genet. - 5 (9) : e1000637 (PMID: 19730683) (doi:10.1371/journal.pgen.1000637)
1 Sep | 2009 Rationalization of genetic testing in patients with apparently sporadic pheochromocytoma/paraganglioma. Cascón, A, López-Jiménez, E, Landa, I, Leskelä, S, Leandro-García, LJ, Maliszewska, A, Letón, R, de la Vega, L, García-Barcina, MJ, Sanabria, C, Alvarez-Escolá, C, Rodríguez-Antona, C , Robledo, M. Horm Metab Res - 41 (9) : 672-675 (PMID: 19343621) (doi:10.1055/s-0029-1202814)
1 Aug | 2009 Improving pharmacovigilance in Europe: TPMT genotyping and phenotyping in the UK and Spain. Gurwitz, D, Rodríguez-Antona, C , Payne, K, Newman, W, Gisbert, JP, de Mesa, EG, Ibarreta, D. Eur J Hum Genet - 17 (8) : 991-998 (PMID: 19223932) (doi:10.1038/ejhg.2009.10)
12 Jun | 2009 Cytochrome P450 2D6 genotyping: potential role in improving treatment outcomes in psychiatric disorders. Kirchheiner, J, Rodriguez-Antona, C . CNS Drugs - 23 (3) : 181-191 (PMID: 19320528) (doi:10.2165/00023210-200923030-00001)
1 Jun | 2009 Determination of CYP2D6 gene copy number by multiplex polymerase chain reaction analysis. Leandro-García, LJ, Leskelä, S, Montero-Conde, C , Landa, I, López-Jimenez, E, Letón, R, Seeringer, A, Kirchheiner, J, Cascón, A, Robledo, M, Rodríguez-Antona, C . Anal Biochem - 389 (1) : 74-76 (PMID: 19303860) (doi:10.1016/j.ab.2009.03.021)
28 May | 2009 Genetics of pheochromocytoma and paraganglioma in Spanish patients. Cascón, A, Pita, G, Burnichon, N, Landa, I, López-Jiménez, E, Montero-Conde, C , Leskelä, S, Leandro-García, LJ, Letón, R, Rodríguez-Antona, C , Díaz, JA, López-Vidriero, E, González-Neira, A, Velasco, A, Matias-Guiu, X, Gimenez-Roqueplo, AP, Robledo, M. J Clin Endocrinol Metab - 94 (5) : 1701-1705 (PMID: 19258401) (doi:10.1210/jc.2008-2756)
1 Apr | 2009 CYP2D6 genotyping for psychiatric patients treated with risperidone: considerations for cost-effectiveness studies. Rodríguez-Antona, C , Gurwitz, D, de Leon, J, Llerena, A, Kirchheiner, J, de Mesa, EG, Ibarreta, D. Pharmacogenomics - 10 (4) : 685-699 (PMID: 19374522) (doi:10.2217/pgs.09.15)
1 Dec | 2008 SDHC mutation in an elderly patient without familial antecedents. López-Jiménez, E, de Campos, JM, Kusak, EM, Landa, I, Leskelä, S, Montero-Conde, C , Leandro-García, LJ, Vallejo, LA, Madrigal, B, Rodríguez-Antona, C , Robledo, M, Cascón, A. Clin Endocrinol (Oxf) - 69 (6) : 906-910 (PMID: 18681855) (doi:10.1111/j.1365-2265.2008.03368.x)
1 Aug | 2008 Characterization of novel CYP2C8 haplotypes and their contribution to paclitaxel and repaglinide metabolism. Rodríguez-Antona, C , Niemi, M, Backman, JT, Kajosaari, LI, Neuvonen, PJ, Robledo, M, Ingelman-Sundberg, M. Pharmacogenomics J - 8 (4) : 268-277 (PMID: 17923851) (doi:10.1038/sj.tpj.6500482)
30 Apr | 2008 Molecular characterisation of a common SDHB deletion in paraganglioma patients. Cascón, A, Landa, I, López-Jiménez, E, Díez-Hernández, A, Buchta, M, Montero-Conde, C, Leskelä, S, Leandro-García, LJ, Letón, R, Rodríguez-Antona, C , Eng, C, Neumann, HP, Robledo, M. J Med Genet - 45 (4) : 233-238 (PMID: 18057081) (doi:10.1136/jmg.2007.054965)
1 Mar | 2008 Impact of genetic polymorphisms in CYP2C8 and rosiglitazone intake on the urinary excretion of dihydroxyeicosatrienoic acids. Kirchheiner, J, Meineke, I, Fuhr, U, Rodríguez-Antona, C , Lebedeva, E, Brockmöller, J. Pharmacogenomics - 9 (3) : 277-288 (PMID: 18303964) (doi:10.2217/14622416.9.3.277)
1 Dec | 2007 Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects. Ingelman-Sundberg, M, Sim, SC, Gomez, A, Rodriguez-Antona, C . Pharmacol Ther - 116 (3) : 496-526 (PMID: 18001838) (doi:10.1016/j.pharmthera.2007.09.004)
1 Nov | 2007 Expression of CYP3A4 as a predictor of response to chemotherapy in peripheral T-cell lymphomas. Rodríguez-Antona, C , Leskelä, S, Zajac, M, Cuadros, M, Alvés, J, Moneo, MV, Martín, C, Cigudosa, JC, Carnero, A, Robledo, M, Benitez, J, Martínez-Delgado, B. Blood - 110 (9) : 3345-3351 (PMID: 17634410) (doi:10.1182/blood-2007-02-075036)
1 Sep | 2007 Cytochrome P450 3A5 is highly expressed in normal prostate cells but absent in prostate cancer. Leskelä, S, Honrado, E, Montero-Conde, C, Landa, I, Cascón, A, Letón, R, Talavera, P, Cózar, JM, Concha, A, Robledo, M, Rodríguez-Antona, C . Endocr Relat Cancer - 14 (3) : 645-654 (PMID: 17914095) (doi:10.1677/ERC-07-0078)
1 Jun | 2007 Loss of the actin regulator HSPC300 results in clear cell renal cell carcinoma protection in Von Hippel-Lindau patients. Cascón, A, Escobar, B, Montero-Conde, C , Rodríguez-Antona, C , Ruiz-Llorente, S , Osorio, A, Mercadillo, F, Letón, R, Campos, JM, García-Sagredo, JM, Benítez, J, Malumbres, M, Robledo, M. Hum Mutat - 28 (6) : 613-621 (PMID: 17311301) (doi:10.1002/humu.20496)
1 Dec | 2006 Novel aspects of drug metabolism and transport. Afzelius, L, Ingelman-Sundberg, M, Karlgren, M, Rodriguez-Antona, C . Drug News Perspect - 19 (10) : 637-651 (PMID: 17299607)
28 Mar | 2006 Gross SDHB deletions in patients with paraganglioma detected by multiplex PCR: a possible hot spot? Cascón, A, Montero-Conde, C , Ruiz-Llorente, S , Mercadillo, F, Letón, R, Rodríguez-Antona, C , Martínez-Delgado, B, Delgado, M, Díez, A, Rovira, A, Díaz, JA, Robledo, M. Genes Chromosomes Cancer - 45 (3) : 213-219 (PMID: 16258955) (doi:10.1002/gcc.20283)
13 Mar | 2006 Cytochrome P450 pharmacogenetics and cancer. Rodriguez-Antona, C , Ingelman-Sundberg, M. Oncogene - 25 (11) : 1679-1691 (PMID: 16550168) (doi:10.1038/sj.onc.1209377)
10 Mar | 2006 Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1. Karlgren, M, Gomez, A, Stark, K, Svärd, J, Rodriguez-Antona, C , Oliw, E, Bernal, ML, Ramón y Cajal, S, Johansson, I, Ingelman-Sundberg, M. Biochem Biophys Res Commun - 341 (2) : 451-458 (PMID: 16426568) (doi:10.1016/j.bbrc.2005.12.200)
9 Dec | 2005 Phenotype-genotype variability in the human CYP3A locus as assessed by the probe drug quinine and analyses of variant CYP3A4 alleles. Rodríguez-Antona, C , Sayi, JG, Gustafsson, LL, Bertilsson, L, Ingelman-Sundberg, M. Biochem Biophys Res Commun - 338 (1) : 299-305 (PMID: 16171783) (doi:10.1016/j.bbrc.2005.09.020)
29 Aug | 2005 Pharmacogenetics of drug-metabolizing enzymes: implications for a safer and more effective drug therapy. Ingelman-Sundberg, M, Rodriguez-Antona, C . Philos Trans R Soc Lond B Biol Sci - 360 (1460) : 1563-1570 (PMID: 16096104) (doi:10.1098/rstb.2005.1685)
5 Aug | 2005 A novel polymorphic cytochrome P450 formed by splicing of CYP3A7 and the pseudogene CYP3AP1. Rodriguez-Antona, C , Axelson, M, Otter, C, Rane, A, Ingelman-Sundberg, M. J Biol Chem - 280 (31) : 28324-28331 (PMID: 15937338) (doi:10.1074/jbc.M502309200)
1 May | 2005 Transcriptional regulation of the human CYP2A6 gene. Pitarque, M, Rodríguez-Antona, C , Oscarson, M, Ingelman-Sundberg, M. J Pharmacol Exp Ther - 313 (2) : 814-822 (PMID: 15671201) (doi:10.1124/jpet.104.081570)
1 Apr | 2005 Identification and phenotype characterization of two CYP3A haplotypes causing different enzymatic capacity in fetal livers. Rodríguez-Antona, C , Jande, M, Rane, A, Ingelman-Sundberg, M. Clin Pharmacol Ther - 77 (4) : 259-270 (PMID: 15903124) (doi:10.1016/j.clpt.2004.11.003)
1 Nov | 2004 New approaches and applications in chemical biology. Gomez, A, Ingelman-Sundberg, M, Johansson, I, Karlgren, M, Rodriguez-Antona, C , Sim, SC. Drug News Perspect - 17 (9) : 594-605 (PMID: 15645017)
1 Jun | 2004 Polymorphic NF-Y dependent regulation of human nicotine C-oxidase (CYP2A6). von Richter, O, Pitarque, M, Rodríguez-Antona, C , Testa, A, Mantovani, R, Oscarson, M, Ingelman-Sundberg, M. Pharmacogenetics - 14 (6) : 369-379 (PMID: 15247629) (doi:10.1097/00008571-200406000-00006)
25 Mar | 2004 A nicotine C-oxidase gene (CYP2A6) polymorphism important for promoter activity. Pitarque, M, von Richter, O, Rodríguez-Antona, C , Wang, J, Oscarson, M, Ingelman-Sundberg, M. Hum Mutat - 23 (3) : 258-266 (PMID: 14974084) (doi:10.1002/humu.20002)
13 May | 2003 Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma. Rodríguez-Antona, C , Bort, R, Jover, R, Tindberg, N, Ingelman-Sundberg, M, Gómez-Lechón, MJ, Castell, JV. Mol Pharmacol - 63 (5) : 1180-1189 (PMID: 12695546) (doi:10.1124/mol.63.5.1180)
1 Jun | 2002 Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells. Rodríguez-Antona, C , Donato, MT, Boobis, A, Edwards, RJ, Watts, PS, Castell, JV, Gómez-Lechón, MJ. Xenobiotica - 32 (6) : 505-520 (PMID: 12160483) (doi:10.1080/00498250210128675)
15 Sep | 2001 Cytochrome P-450 mRNA expression in human liver and its relationship with enzyme activity. Rodríguez-Antona, C , Donato, MT, Pareja, E, Gómez-Lechón, MJ, Castell, JV. Arch Biochem Biophys - 393 (2) : 308-315 (PMID: 11556818) (doi:10.1006/abbi.2001.2499)
20 Nov | 2000 CYP2A5/CYP2A6 expression in mouse and human hepatocytes treated with various in vivo inducers. Donato, MT, Viitala, P, Rodriguez-Antona, C , Lindfors, A, Castell, JV, Raunio, H, Gómez-Lechón, MJ, Pelkonen, O. Drug Metab Dispos - 28 (11) : 1321-1326 (PMID: 11038160)
1 Apr | 2000 Quantitative RT-PCR measurement of human cytochrome P-450s: application to drug induction studies. Rodríguez-Antona, C , Jover, R, Gómez-Lechón, MJ, Castell, JV. Arch Biochem Biophys - 376 (1) : 109-116 (PMID: 10729196) (doi:10.1006/abbi.2000.1697)