21 Apr | 2024 Tumors of the nervous system and hearing loss: Beyond vestibular schwannomas. Ruiz-García, C , Lassaletta, L , López-Larrubia, P , Varela-Nieto, I , Murillo-Cuesta, S . Hear Res - 447 : 109012 (PMID: 38703433) (doi:10.1016/j.heares.2024.109012)
11 Apr | 2024 A murine model for the del(GJB6-D13S1830) deletion recapitulating the phenotype of human DFNB1 hearing impairment: generation and functional and histopathological study. Domínguez-Ruiz, M, Murillo-Cuesta, S , Contreras, J , Cantero, M, Garrido, G, Martín-Bernardo, B, Gómez-Rosas, E, Fernández, A, Del Castillo, FJ, Montoliu, L, Varela-Nieto, I , Del Castillo, I. BMC Genomics - 25 (1) : 359 (PMID: 38605287) (doi:10.1186/s12864-024-10289-z)
23 Mar | 2024 Intraoperative assessment of cochlear nerve functionality in various vestibular schwannoma scenarios: Lessons learned. Lassaletta, L , Calvino, M, Díaz, M, Morales-Puebla, JM, Sánchez-Cuadrado, I, Varela-Nieto, I , Gavilán, J. Hear Res - 446 : 108997 (PMID: 38564963) (doi:10.1016/j.heares.2024.108997)
10 Feb | 2024 Clinical practice guideline on the management of vestibular schwannoma. Lassaletta, L , Acle Cervera, L, Altuna, X, Amilibia Cabeza, E, Arístegui Ruiz, M, Batuecas Caletrio, Á, Benítez Del Rosario, J, Cabanillas Farpón, R, Costales Marcos, M, Escada, P, Espinosa-Sánchez, JM, García Leal, R, Gavilán, J, Gómez Martínez, J, González-Aguado, R, Martinez-Glez, V, Guerra Jiménez, G, Harguindey Antolí-Candela, A, Hernández García, BJ, Orús Dotú, C, Polo López, R, Manrique, M, Martín Sanz, E, Martínez Álvarez, R, Martínez, H, Martínez-Martínez, M, Rey-Martinez, J, Ropero Romero, F, Santa Cruz Ruiz, S, Vallejo, LÁ, Soto Varela, A, Varela-Nieto, I , Morales Puebla, JM. Acta Otorrinolaringol Esp (Engl Ed) (PMID: 38346489) (doi:10.1016/j.otoeng.2023.10.005)
5 Apr | 2023 Dysfunction of programmed embryo senescence is linked to genetic developmental defects. de Lope, C , García-Lucena, R , Magariños, M , León, Y , Casa-Rodríguez, N , Contreras, N , Escudero-Iriarte, C , Varela-Nieto, I , Maire, P, Palmero, I . Development (PMID: 37017267) (doi:10.1242/dev.200903)
19 Jan | 2023 IGF-1 Controls Metabolic Homeostasis and Survival in HEI-OC1 Auditory Cells through AKT and mTOR Signaling. García-Mato, Á , Cervantes, B , Rodríguez-de la Rosa, L , Varela-Nieto, I . Antioxidants (Basel) - 12 (2) (PMID: 36829792) (doi:10.3390/antiox12020233)
13 Oct | 2022 Editorial: Inner ear biology: Development, physiopathology, repair and recovery. Alsina, B, Heller, S, Varela-Nieto, I . Front Cell Dev Biol - 10 : 1049463 (PMID: 36313579) (doi:10.3389/fcell.2022.1049463)
13 Apr | 2022 Editorial: Otologic Trauma, Pathology, and Therapy. Landegger, LD, Fujita, T, Jan, TA, Varela-Nieto, I . Front Cell Neurosci - 16 : 900074 (PMID: 35496907) (doi:10.3389/fncel.2022.900074)
30 Mar | 2022 Editorial: The Role of Cellular Senescence in Health and Disease. Palmero, I , Gorgoulis, V, Varela-Nieto, I . Front Cell Neurosci - 16 : 882417 (PMID: 35431814) (doi:10.3389/fncel.2022.882417)
29 Sep | 2021 Insulin-like Growth Factor 1 Signaling in Mammalian Hearing. García-Mato, Á , Cervantes, B , Murillo-Cuesta, S , Rodríguez-de la Rosa, L , Varela-Nieto, I . Genes (Basel) - 12 (10) (PMID: 34680948) (doi:10.3390/genes12101553)
1 Sep | 2021 Use of Radical Oxygen Species Scavenger Nitrones to Treat Oxidative Stress-Mediated Hearing Loss: State of the Art and Challenges. Varela-Nieto, I , Murillo-Cuesta, S , Rodríguez-de la Rosa, L , Oset-Gasque, MJ, Marco-Contelles, J. Front Cell Neurosci - 15 : 711269 (PMID: 34539349) (doi:10.3389/fncel.2021.711269)
25 Aug | 2021 Dual-Specificity Phosphatase 1 (DUSP1) Has a Central Role in Redox Homeostasis and Inflammation in the Mouse Cochlea. Bermúdez-Muñoz, JM , Celaya, AM , García-Mato, Á , Muñoz-Espín, D, Rodríguez-de la Rosa, L , Serrano, M, Varela-Nieto, I . Antioxidants (Basel) - 10 (9) (PMID: 34572983) (doi:10.3390/antiox10091351)
3 Jul | 2021 IGF-1 Haploinsufficiency Causes Age-Related Chronic Cochlear Inflammation and Increases Noise-Induced Hearing Loss. Celaya, AM , Rodríguez-de la Rosa, L , Bermúdez-Muñoz, JM , Zubeldia, JM, Romá-Mateo, C, Avendaño, C, Pallardó, FV, Varela-Nieto, I . Cells - 10 (7) (PMID: 34359856) (doi:10.3390/cells10071686)
4 Jun | 2021 Ceramide Kinase Inhibition Blocks IGF-1-Mediated Survival of Otic Neurosensory Progenitors by Impairing AKT Phosphorylation. León, Y , Magariños, M , Varela-Nieto, I . Front Cell Dev Biol - 9 : 678760 (PMID: 34179008) (doi:10.3389/fcell.2021.678760)
1 Apr | 2021 Therapeutic efficiency of the APAF-1 antagonist LPT99 in a rat model of cisplatin-induced hearing loss. Murillo-Cuesta, S , Celaya, AM , Cervantes, B , Bermúdez-Muñoz, JM , Rodríguez-de la Rosa, L , Contreras, J , Sánchez-Pérez, I , Varela-Nieto, I . Clin Transl Med - 11 (4) : e363 (PMID: 33931965) (doi:10.1002/ctm2.363)
9 Feb | 2021 Editorial: Neuroimmunology of the Inner Ear. Perin, P, Marino, F, Varela-Nieto, I , Szczepek, AJ. Front Neurol - 12 : 635359 (PMID: 33633679) (doi:10.3389/fneur.2021.635359)
8 Feb | 2021 Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Klionsky, DJ, [ .., ], Bartolome, A , [ .., ], Cuadrado, A , [ .., ], Escalante, R , [ .., ], García-Sanz, P , [ .., ], Lastres-Becker, I , [ .., ], León, Y , [ .., ], Martin-Sanz, P , [ .., ], Pajares, M , [ .., ], Rojo, AI , [ .., ], Valverde, AM , [ .., ], Varela-Nieto, I , [ .., ], Villalobo, A , [ .., ], Vincent, O , [ .., ], Tong, CK. Autophagy (PMID: 33634751) (doi:10.1080/15548627.2020.1797280)
22 Nov | 2020 G6PD overexpression protects from oxidative stress and age-related hearing loss. Bermúdez-Muñoz, JM , Celaya, AM , Hijazo-Pechero, S , Wang, J, Serrano, M, Varela-Nieto, I . Aging Cell (PMID: 33222382) (doi:10.1111/acel.13275)
14 Oct | 2020 The Value of Mouse Models of Rare Diseases: A Spanish Experience. Murillo-Cuesta, S , Artuch, R, Asensio, F, de la Villa, P, Dierssen, M, Enríquez, JA, Fillat, C, Fourcade, S, Ibáñez, B, Montoliu, L, Oliver, E, Pujol, A, Salido, E, Vallejo, M , Varela-Nieto, I . Front Genet - 11 : 583932 (PMID: 33173540) (doi:10.3389/fgene.2020.583932)
25 Aug | 2020 Drug development for noise-induced hearing loss. Varela-Nieto, I , Murillo-Cuesta, S , Calvino, M, Cediel, R , Lassaletta, L . Expert Opin Drug Discov (PMID: 32838572) (doi:10.1080/17460441.2020.1806232)
17 Aug | 2020 Otic Neurogenesis Is Regulated by TGFβ in a Senescence-Independent Manner. Magariños, M , Barajas-Azpeleta, R, Varela-Nieto, I , R Aburto, M. Frontiers in cellular neuroscience - 14 : 217 (PMID: 32973450) (doi:10.3389/fncel.2020.00217)
18 Sep | 2019 Biomarkers in Vestibular Schwannoma-Associated Hearing Loss. Lassaletta, L , Calvino, M, Morales-Puebla, JM, Lapunzina, P, Rodriguez-de la Rosa, L , Varela-Nieto, I , Martinez-Glez, V. Front Neurol - 10 : 978 (PMID: 31620068) (doi:10.3389/fneur.2019.00978)
14 Sep | 2019 Solid Lipid Nanoparticles Loaded with Glucocorticoids Protect Auditory Cells from Cisplatin-Induced Ototoxicity. Cervantes, B , Arana, L, Murillo-Cuesta, S , Bruno, M, Alkorta, I, Varela-Nieto, I . J Clin Med - 8 (9) (PMID: 31540035) (doi:10.3390/jcm8091464)
1 May | 2019 Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia. Partearroyo, T , Murillo-Cuesta, S , Vallecillo, N , Bermúdez-Muñoz, JM , Rodríguez-de la Rosa, L , Mandruzzato, G, Celaya, AM , Zeisel, SH, Pajares, MA , Varela-Moreiras, G , Varela-Nieto, I . FASEB J. - 33 (5) : 5942-5956 (PMID: 30753104) (doi:10.1096/fj.201801533R)
11 Apr | 2019 TGFβ2-induced senescence during early inner ear development. Gibaja, A , Aburto, MR , Pulido, S , Collado, M, Hurle, JM, Varela-Nieto, I , Magariños, M . Scientific reports - 9 (1) : 5912 (PMID: 30976015) (doi:10.1038/s41598-019-42040-0)
2 Apr | 2019 Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss. Celaya, AM , Sánchez-Pérez, I , Bermúdez-Muñoz, JM , Rodríguez-de la Rosa, L , Pintado-Berninches, L , Perona, R , Murillo-Cuesta, S , Varela-Nieto, I . Elife - 8 (PMID: 30938680) (doi:10.7554/eLife.39159)
1 Mar | 2019 Neuroglial Involvement in Abnormal Glutamate Transport in the Cochlear Nuclei of the Igf1-/- Mouse. Fuentes-Santamaría, V, Alvarado, JC, Rodríguez-de la Rosa, L , Juiz, JM, Varela-Nieto, I . Front Cell Neurosci - 13 : 67 (PMID: 30881288) (doi:10.3389/fncel.2019.00067)
23 Jan | 2019 Complementary and distinct roles of autophagy, apoptosis and senescence during early inner ear development. Varela-Nieto, I , Palmero, I , Magariños, M . Hear. Res. (PMID: 30711386) (doi:10.1016/j.heares.2019.01.014)
15 Nov | 2018 Editorial: Hormones and Neural Aging: Lessons From Experimental Models. Varela-Nieto, I , Chowen, JA, García-Segura, LM. Front Aging Neurosci - 10 : 374 (PMID: 30498442) (doi:10.3389/fnagi.2018.00374)
2 Oct | 2018 Modelling physical resilience in ageing mice. Schosserer, M, Banks, G, Dogan, S, Dungel, P, Fernandes, A, Presen, DM, Matheu, A, Osuchowski, M, Potter, P, Sanfeliu, C, Tuna, BG, Varela-Nieto, I , Bellantuono, I. Mech. Ageing Dev. (PMID: 30290161) (doi:10.1016/j.mad.2018.10.001)
1 Sep | 2018 Tackling frailty and functional decline: Background of the action group A3 of the European innovation partnership for active and healthy ageing. Cano, A, Dargent, G, Carriazo, A, López-Samaniego, L, Apostolo, J, Campos, E, Holland, C, Varela-Nieto, I , Luz Sánchez-Sánchez, M, Illario, M, Iaccarino, G, Roller, RE, Goossens, E, Vollenbroek-Hutten, M, Pais, S, Schena, F, Musian, D, Alvino, S, Maggio, M, Liotta, G, Ussai, S, Orfila, F, O'Caoimh, R, Paul, C, Pazzi, S, Romano, V, Obbia, P. Maturitas - 115 : 69-73 (PMID: 30049350) (doi:10.1016/j.maturitas.2018.06.009)
5 Jul | 2018 MPZL2, Encoding the Epithelial Junctional Protein Myelin Protein Zero-like 2, Is Essential for Hearing in Man and Mouse. Wesdorp, M, Murillo-Cuesta, S , Peters, T, Celaya, AM , Oonk, A, Schraders, M, Oostrik, J, Gomez-Rosas, E, Beynon, AJ, Hartel, BP, Okkersen, K, Koenen, HJPM, Weeda, J, Lelieveld, S, Voermans, NC, Joosten, I, Hoyng, CB, Lichtner, P, Kunst, HPM, Feenstra, I, de Bruijn, SE, , , Admiraal, RJC, Yntema, HG, van Wijk, E, Del Castillo, I, Serra, P, Varela-Nieto, I , Pennings, RJE, Kremer, H. Am. J. Hum. Genet. - 103 (1) : 74-88 (PMID: 29961571) (doi:10.1016/j.ajhg.2018.05.011)
22 Jan | 2018 Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss. Espino Guarch, M, Font-Llitjós, M, Murillo-Cuesta, S , Errasti-Murugarren, E, Celaya, AM , Girotto, G, Vuckovic, D, Mezzavilla, M, Vilches, C, Bodoy, S, Sahún, I, González, L , Prat, E, Zorzano, A, Dierssen, M, Varela-Nieto, I , Gasparini, P, Palacín, M, Nunes, V. Elife - 7 (PMID: 29355479) (doi:10.7554/eLife.31511)
14 Dec | 2017 The expression of oxidative stress response genes is modulated by a combination of resveratrol and N-acetylcysteine to ameliorate ototoxicity in the rat cochlea. García-Alcántara, F , Murillo-Cuesta, S , Pulido, S , Bermúdez-Muñoz, JM , Martínez-Vega, R , Milo, M , Varela-Nieto, I , Rivera, T . Hear. Res. - 358 : 10-21 (PMID: 29304389) (doi:10.1016/j.heares.2017.12.004)
12 Dec | 2017 The Role of Insulin-Like Growth Factor 1 in the Progression of Age-Related Hearing Loss. Rodríguez-de la Rosa, L , Lassaletta, L , Calvino, M, Murillo-Cuesta, S , Varela-Nieto, I . Front Aging Neurosci - 9 : 411 (PMID: 29311900) (doi:10.3389/fnagi.2017.00411)
1 Dec | 2017 Usefulness of Electrical Auditory Brainstem Responses to Assess the Functionality of the Cochlear Nerve Using an Intracochlear Test Electrode. Lassaletta, L , Polak, M, Huesers, J, Díaz-Gómez, M, Calvino, M, Varela-Nieto, I , Gavilán, J. Otol. Neurotol. - 38 (10) : e413-e420 (PMID: 29076926) (doi:10.1097/MAO.0000000000001584)
26 May | 2017 Autophagy in the Vertebrate Inner Ear. Magariños, M , Pulido, S , Aburto, MR , de Iriarte Rodríguez, R, Varela-Nieto, I . Front Cell Dev Biol - 5 : 56 (PMID: 28603711) (doi:10.3389/fcell.2017.00056)
25 Apr | 2017 Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss. Partearroyo, T , Vallecillo, N , Pajares, MA , Varela-Moreiras, G , Varela-Nieto, I . Front Mol Neurosci - 10 : 107 (PMID: 28487633) (doi:10.3389/fnmol.2017.00107)
8 Mar | 2017 A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection. Murillo-Cuesta, S , Vallecillo, N , Cediel, R , Celaya, AM , Lassaletta, L , Varela-Nieto, I , Contreras, J . J Vis Exp (PMID: 28362376) (doi:10.3791/54951)
19 Oct | 2016 Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Klionsky, DJ, [ .., ], Bartolomé, A , [ .., ], Escalante, R , [ .., ], Magariños, M , [ .., ], Martín-Sanz, P , [ .., ], Sanchez-Prieto, R , [ .., ], Valverde, AM , [ .., ], Varela-Nieto, I , [ .., ], Zughaier, SM. Autophagy - 12 (1) : 1-222 (PMID: 26799652) (doi:10.1080/15548627.2015.1100356)
1 Sep | 2016 Autophagy resolves early retinal inflammation in Igf1-deficient mice. Arroba, AI , Rodríguez-de la Rosa, L , Murillo-Cuesta, S , Vaquero-Villanueva, L, Hurlé, JM, Varela-Nieto, I , Valverde, ÁM . Dis Model Mech - 9 (9) : 965-974 (PMID: 27483352) (doi:10.1242/dmm.026344)
31 Aug | 2016 Long-Term Dietary Folate Deficiency Accelerates Progressive Hearing Loss on CBA/Ca Mice. Martínez-Vega, R , Murillo-Cuesta, S , Partearroyo, T , Varela-Moreiras, G , Varela-Nieto, I , Pajares, MA . Front Aging Neurosci - 8 : 209 (PMID: 27630560) (doi:10.3389/fnagi.2016.00209)
18 Jul | 2016 Frailty in mouse ageing: A conceptual approach. von Zglinicki, T, Nieto, IV , Brites, D, Karagianni, N, Ortolano, S, Georgopoulos, S, Cardoso, AL, Novella, S, Lepperdinger, G, Trendelenburg, AU, van Os, R. Mech. Ageing Dev. (PMID: 27443148) (doi:10.1016/j.mad.2016.07.004)
1 Mar | 2016 Erratum to: IGF-1 deficiency causes atrophic changes associated with upregulation of VGluT1 and downregulation of MEF2 transcription factors in the mouse cochlear nuclei. Fuentes-Santamaría, V, Alvarado, JC, Rodríguez-de la Rosa, L , Murillo-Cuesta, S , Contreras, J , Juiz, JM, Varela-Nieto, I . Brain Struct Funct - 221 (2) : 1205 (PMID: 25416135) (doi:10.1007/s00429-014-0945-z)
1 Mar | 2016 IGF-1 deficiency causes atrophic changes associated with upregulation of VGluT1 and downregulation of MEF2 transcription factors in the mouse cochlear nuclei. Fuentes-Santamaría, V, Alvarado, JC, Rodríguez-de la Rosa, L , Murillo-Cuesta, S , Contreras, J , Juiz, JM, Varela-Nieto, I . Brain Struct Funct - 221 (2) : 709-734 (PMID: 25378055) (doi:10.1007/s00429-014-0934-2)
1 Mar | 2016 Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing. Buniello, A, Ingham, NJ, Lewis, MA, Huma, AC, Martinez-Vega, R, Varela-Nieto, I , Vizcay-Barrena, G, Fleck, RA, Houston, O, Bardhan, T, Johnson, SL, White, JK, Yuan, H, Marcotti, W, Steel, KP. EMBO Mol Med - 8 (3) : 191-207 (PMID: 26881968) (doi:10.15252/emmm.201505523)
15 Dec | 2015 Long-term omega-3 fatty acid supplementation prevents expression changes in cochlear homocysteine metabolism and ameliorates progressive hearing loss in C57BL/6J mice. Martínez-Vega, R , Partearroyo, T , Vallecillo, N , Varela-Moreiras, G , Pajares, MA , Varela-Nieto, I . J. Nutr. Biochem. - 26 (12) : 1424-1433 (PMID: 26321228) (doi:10.1016/j.jnutbio.2015.07.011)
8 Dec | 2015 Age-regulated function of autophagy in the mouse inner ear. de Iriarte Rodríguez, R, Pulido, S , Rodríguez-de la Rosa, L , Magariños, M , Varela-Nieto, I . Hear. Res. - 330 (Pt A) : 39-50 (PMID: 26235979) (doi:10.1016/j.heares.2015.07.020)
1 Nov | 2015 Loss of lysophosphatidic acid receptor LPA1 alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex. García-Díaz, B, Riquelme, R , Varela-Nieto, I , Jiménez, AJ, de Diego, I, Gómez-Conde, AI, Matas-Rico, E, Aguirre, JÁ, Chun, J, Pedraza, C, Santín, LJ, Fernández, O, Rodríguez de Fonseca, F, Estivill-Torrús, G. Brain Struct Funct - 220 (6) : 3701-3720 (PMID: 25226845) (doi:10.1007/s00429-014-0885-7)
22 Oct | 2015 Mild cognitive decline. A position statement of the Cognitive Decline Group of the European Innovation Partnership for Active and Healthy Ageing (EIPAHA). Apostolo, J, Holland, C, O'Connell, MD, Feeney, J, Tabares-Seisdedos, R, Tadros, G, Campos, E, Santos, N, Robertson, DA, Marcucci, M, Varela-Nieto, I , Crespo-Facorro, B, Vieta, E, Navarro-Pardo, E, Selva-Vera, G, Balanzá-Martínez, V, Cano, A. Maturitas (PMID: 26520249) (doi:10.1016/j.maturitas.2015.10.008)
3 Oct | 2015 Public investment in biomedical research in Europe. Bouillon, R, Slordahl, S, Nogueria, MM, Steinhausen, K, Varela-Nieto, I , Pacini, G, Röllinghoff, M, Syka, J. Lancet - 386 (10001) : 1335 (PMID: 26460768) (doi:10.1016/S0140-6736(15)00326-8)
1 Oct | 2015 C-Raf deficiency leads to hearing loss and increased noise susceptibility. de Iriarte Rodríguez, R, Magariños, M , Pfeiffer, V, Rapp, UR, Varela-Nieto, I . Cell. Mol. Life Sci. - 72 (20) : 3983-3998 (PMID: 25975225) (doi:10.1007/s00018-015-1919-x)
1 Sep | 2015 Comparative gene expression study of the vestibular organ of the Igf1 deficient mouse using whole-transcript arrays. Rodríguez-de la Rosa, L , Sánchez-Calderón, H , Contreras, J , Murillo-Cuesta, S , Falagan, S, Avendaño, C, Dopazo, J, Varela-Nieto, I , Milo, M . Hear. Res. (PMID: 26341476) (doi:10.1016/j.heares.2015.08.016)
17 Jul | 2015 Editorial: Aging, neurogenesis and neuroinflammation in hearing loss and protection. Magariños, M , Milo, M , Varela-Nieto, I . Front Aging Neurosci - 7 : 138 (PMID: 26236234) (doi:10.3389/fnagi.2015.00138)
12 May | 2015 Corrigendum to: Swept-sine noise-induced damage as a hearing loss model for preclinical assays. Sanz, L , Murillo-Cuesta, S , Cobo, P, Cediel, R , Contreras, J , Rivera, T , Varela-Nieto, I , Avendaño, C. Front Aging Neurosci - 7 : 79 (PMID: 26029100) (doi:10.3389/fnagi.2015.00079)
8 May | 2015 Corrigendum: Transforming growth factor β1 inhibition protects from noise-induced hearing loss. Murillo-Cuesta, S , Rodríguez-de la Rosa, L , Contreras, J , Celaya, AM , Camarero, G , Rivera, T , Varela-Nieto, I . Front Aging Neurosci - 7 : 72 (PMID: 26005416) (doi:10.3389/fnagi.2015.00072)
1 Apr | 2015 Differential organ phenotypes after postnatal Igf1r gene conditional deletion induced by tamoxifen in UBC-CreERT2; Igf1r (fl/fl) double transgenic mice. López, IP, Rodriguez-de la Rosa, L , Pais, RS, Piñeiro-Hermida, S, Torrens, R, Contreras, J , Varela-Nieto, I , Pichel, JG. Transgenic Res. - 24 (2) : 279-294 (PMID: 25238791) (doi:10.1007/s11248-014-9837-5)
20 Mar | 2015 Transforming growth factor β1 inhibition protects from noise-induced hearing loss. Murillo-Cuesta, S , Rodríguez-de la Rosa, L , Contreras, J , Celaya, AM , Camarero, G , Rivera, T , Varela-Nieto, I . Front Aging Neurosci - 7 : 32 (PMID: 25852546) (doi:10.3389/fnagi.2015.00032)
16 Feb | 2015 Swept-sine noise-induced damage as a hearing loss model for preclinical assays. Sanz, L , Murillo-Cuesta, S , Cobo, P, Cediel-Algovia, R, Contreras, J , Rivera, T , Varela-Nieto, I , Avendaño, C. Front Aging Neurosci - 7 : 7 (PMID: 25762930) (doi:10.3389/fnagi.2015.00007)
4 Feb | 2015 Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism. Martínez-Vega, R , Garrido, F , Partearroyo, T , Cediel, R , Zeisel, SH, Martínez-Álvarez, C, Varela-Moreiras, G , Varela-Nieto, I , Pajares, MA . FASEB J. - 29 (2) : 418-432 (PMID: 25384423) (doi:10.1096/fj.14-259283)
29 Jan | 2015 Targeting cholesterol homeostasis to fight hearing loss: a new perspective. Malgrange, B, Varela-Nieto, I , de Medina, P, Paillasse, MR. Front Aging Neurosci - 7 : 3 (PMID: 25688206) (doi:10.3389/fnagi.2015.00003)
4 Feb | 2014 Treatment with N- and C-terminal peptides of parathyroid hormone-related protein partly compensate the skeletal abnormalities in IGF-I deficient mice. Rodríguez-de la Rosa, L , López-Herradón, A, Portal-Núñez, S, Murillo-Cuesta, S , Lozano, D, Cediel, R , Varela-Nieto, I , Esbrit, P. PLoS ONE - 9 (2) : e87536 (PMID: 24503961) (doi:10.1371/journal.pone.0087536)
21 Nov | 2013 Programmed cell senescence during mammalian embryonic development. Muñoz-Espín, D, Cañamero, M, Maraver, A, Gómez-López, G, Contreras, J , Murillo-Cuesta, S , Rodríguez-Baeza, A, Varela-Nieto, I , Ruberte, J, Collado, M, Serrano, M. Cell - 155 (5) : 1104-1118 (PMID: 24238962) (doi:10.1016/j.cell.2013.10.019)
1 Jul | 2013 IGF-I deficiency and hearing loss: molecular clues and clinical implications. Varela-Nieto, I , Murillo-Cuesta, S , Rodríguez-de la Rosa, L , Lassatetta, L, Contreras, J . Pediatr Endocrinol Rev - 10 (4) : 460-472 (PMID: 23957197)
1 Nov | 2012 Early development of the vertebrate inner ear. Magariños, M , Contreras, J , Aburto, MR , Varela-Nieto, I . Anat Rec (Hoboken) - 295 (11) : 1775-1790 (PMID: 23044927) (doi:10.1002/ar.22575)
4 Oct | 2012 Early otic development depends on autophagy for apoptotic cell clearance and neural differentiation. Aburto, MR , Sánchez-Calderón, H , Hurlé, JM, Varela-Nieto, I , Magariños, M . Cell Death Dis - 3 : e394 (PMID: 23034329) (doi:10.1038/cddis.2012.132)
2 Aug | 2012 Autophagy during vertebrate development. Aburto, MR , Hurlé, JM, Varela-Nieto, I , Magariños, M . Cells - 1 (3) : 428-448 (PMID: 24710484) (doi:10.3390/cells1030428)
4 May | 2012 Drug delivery to the inner ear: strategies and their therapeutic implications for sensorineural hearing loss. Rivera, T , Sanz, L , Camarero, G , Varela-Nieto, I . Curr Drug Deliv - 9 (3) : 231-242 (PMID: 22283653)
1 May | 2012 Age-related functional and structural retinal modifications in the Igf1-/- null mouse. Rodriguez-de la Rosa, L , Fernandez-Sanchez, L, Germain, F, Murillo-Cuesta, S , Varela-Nieto, I , de la Villa, P, Cuenca, N. Neurobiol. Dis. - 46 (2) : 476-485 (PMID: 22402333) (doi:10.1016/j.nbd.2012.02.013)
30 Mar | 2012 Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function. Murillo-Cuesta, S , Camarero, G , González-Rodríguez, A , De La Rosa, LR , Burks, DJ, Avendaño, C, Valverde, AM , Varela-Nieto, I . Mol. Med. - 18 : 260-269 (PMID: 22160220) (doi:10.2119/molmed.2011.00328)
23 Jan | 2012 AKT signaling mediates IGF-I survival actions on otic neural progenitors. Aburto, MR , Magariños, M , Leon, Y , Varela-Nieto, I , Sanchez-Calderon, H . PLoS ONE - 7 (1) : e30790 (PMID: 22292041) (doi:10.1371/journal.pone.0030790)
25 Jul | 2011 The role of insulin-like growth factor-I in the physiopathology of hearing. Murillo-Cuesta, S , Rodríguez-de la Rosa, L , Cediel, R , Lassaletta, L , Varela-Nieto, I . Front Mol Neurosci - 4 : 11 (PMID: 21845174) (doi:10.3389/fnmol.2011.00011)
28 Dec | 2010 RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development. Magariños, M , Aburto, MR , Sánchez-Calderón, H , Muñoz-Agudo, C , Rapp, UR, Varela-Nieto, I . PLoS ONE - 5 (12) : e14435 (PMID: 21203386) (doi:10.1371/journal.pone.0014435)
23 Jun | 2010 A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice. Riquelme, R , Cediel, R , Contreras, J , la Rosa Lourdes, RD , Murillo-Cuesta, S , Hernandez-Sanchez, C, Zubeldia, JM , Cerdan, S , Varela-Nieto, I . Front Neuroanat - 4 : 27 (PMID: 20661454) (doi:10.3389/fnana.2010.00027)
16 Jun | 2010 European scientific, ethical, and legal issues on human stem cell research and regenerative medicine. Hovatta, O, Stojkovic, M, Nogueira, M, Varela-Nieto, I . Stem Cells - 28 (6) : 1005-1007 (PMID: 20533567) (doi:10.1002/stem.436)
1 Apr | 2010 Comparison of different aminoglycoside antibiotic treatments to refine ototoxicity studies in adult mice. Murillo-Cuesta, S , Contreras, J , Cediel, R , Varela-Nieto, I . Lab. Anim. - 44 (2) : 124-131 (PMID: 19858169) (doi:10.1258/la.2009.009046)
1 Feb | 2010 Melanin precursors prevent premature age-related and noise-induced hearing loss in albino mice. Murillo-Cuesta, S , Contreras, J , Zurita, E, Cediel, R , Cantero, M, Varela-Nieto, I , Montoliu, L. Pigment Cell Melanoma Res - 23 (1) : 72-83 (PMID: 19843244) (doi:10.1111/j.1755-148X.2009.00646.x)
25 Jan | 2010 RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors. Sanchez-Calderon, H , Rodriguez-de la Rosa, L , Milo, M , Pichel, JG, Holley, M, Varela-Nieto, I . PLoS ONE - 5 (1) : e8699 (PMID: 20111592) (doi:10.1371/journal.pone.0008699)
24 Nov | 2009 Direct drug application to the round window: a comparative study of ototoxicity in rats. Murillo-Cuesta, S , García-Alcántara, F , Vacas, E , Sistiaga, JA, Camarero, G , Varela-Nieto, I , Rivera, T . Otolaryngol Head Neck Surg - 141 (5) : 584-590 (PMID: 19861195) (doi:10.1016/j.otohns.2009.07.014)
11 Nov | 2009 Behavioral phenotype of maLPA1-null mice: increased anxiety-like behavior and spatial memory deficits. Santin, LJ, Bilbao, A, Pedraza, C, Matas-Rico, E, López-Barroso, D, Castilla-Ortega, E, Sánchez-López, J, Riquelme, R , Varela-Nieto, I , de la Villa, P, Suardíaz, M, Chun, J, De Fonseca, FR, Estivill-Torrús, G. Genes Brain Behav. - 8 (8) : 772-784 (PMID: 19689455) (doi:10.1111/j.1601-183X.2009.00524.x)
31 Jul | 2009 RasGRF1 disruption causes retinal photoreception defects and associated transcriptomic alterations. Fernández-Medarde, A, Barhoum, R, Riquelme, R , Porteros, A, Núñez, A, de Luis, A, de Las Rivas, J, de la Villa, P, Varela-Nieto, I , Santos, E. J. Neurochem. - 110 (2) : 641-652 (PMID: 19457086) (doi:10.1111/j.1471-4159.2009.06162.x)
1 Oct | 2008 Spatial and temporal segregation of auditory and vestibular neurons in the otic placode. Bell, D, Streit, A, Gorospe, I , Varela-Nieto, I , Alsina, B, Giraldez, F. Dev. Biol. - 322 (1) : 109-120 (PMID: 18674529) (doi:10.1016/j.ydbio.2008.07.011)
12 Feb | 2008 [Neurotrophic action of insulin-like growth factor-I in the inner ear]. Rodríguez-de la Rosa, L , Contreras-Rodríguez, J , Cediel-Algovia, R , León, Y , Sánchez-Calderón, H , Murillo-Cuesta, S , Riquelme-Galiana, R , de Diego-Sastre, JI , Prim-Espada, MP , Varela-Nieto, I , , . Rev Neurol - 45 (4) : 245-250 (PMID: 17668408)
24 Sep | 2007 A network of growth and transcription factors controls neuronal differentation and survival in the developing ear. Sanchez-Calderon, H , Milo, M , Leon, Y , Varela-Nieto, I . Int. J. Dev. Biol. - 51 (6-7) : 557-570 (PMID: 17891717) (doi:10.1387/ijdb.072373hs)
5 Apr | 2007 Anti-apoptotic actions of insulin-like growth factors: lessons from development and implications in neoplastic cell transformation. Varela-Nieto, I , Hartl, M, Gorospe, I , León, Y . Curr. Pharm. Des. - 13 (7) : 687-703 (PMID: 17346184)
15 Mar | 2007 Pollen-induced airway inflammation, hyper-responsiveness and apoptosis in a murine model of allergy. Conejero, L, Higaki, Y, Baeza, ML, Fernández, M , Varela-Nieto, I , Zubeldia, JM. Clin. Exp. Allergy - 37 (3) : 331-338 (PMID: 17359383) (doi:10.1111/j.1365-2222.2007.02660.x)
1 Jan | 2006 Sensorineural hearing loss in insulin-like growth factor I-null mice: a new model of human deafness. Cediel, R , Riquelme, R , Contreras, J , Díaz, A, Varela-Nieto, I . Eur J Neurosci - 23 (2) : 587-590 (PMID: 16420467) (doi:10.1111/j.1460-9568.2005.04584.x)
22 Dec | 2005 Regulation of vertebrate sensory organ development: a scenario for growth hormone and insulin-like growth factors action. Diaz-Casares, A, Leon, Y , de la Rosa, EJ, Varela-Nieto, I . Adv. Exp. Med. Biol. - 567 : 221-242 (PMID: 16370141) (doi:10.1007/0-387-26274-1_9)
3 Jan | 2005 Phosphorylation of glycosyl-phosphatidylinositol by phosphatidylinositol 3-kinase changes its properties as a substrate for phospholipases. Jones, DR, Pañeda, C , Villar, AV, Alonso, A, Goñi, FM, Bütikofer, P, Brodbeck, U, Shepherd, PR, Varela-Nieto, I . FEBS Lett. - 579 (1) : 59-65 (PMID: 15620691) (doi:10.1016/j.febslet.2004.11.035)
6 Oct | 2004 Trophic effects of insulin-like growth factor-I (IGF-I) in the inner ear. Varela-Nieto, I , Morales-Garcia, JA , Vigil, P, Diaz-Casares, A, Gorospe, I , Sánchez-Galiano, S, Cañon, S , Camarero, G , Contreras, J , Cediel, R , Leon, Y . Hear. Res. - 196 (1-2) : 19-25 (PMID: 15464297) (doi:10.1016/j.heares.2003.12.022)
1 Mar | 2004 Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis. Marí, M, Colell, A, Morales, A, Pañeda, C , Varela-Nieto, I , García-Ruiz, C, Fernández-Checa, JC. J. Clin. Invest. - 113 (6) : 895-904 (PMID: 15067322) (doi:10.1172/JCI19852)
16 Dec | 2003 Growth factors and early development of otic neurons: interactions between intrinsic and extrinsic signals. Alsina, B, Giraldez, F, Varela-Nieto, I . Curr. Top. Dev. Biol. - 57 : 177-206 (PMID: 14674481)
15 Oct | 2003 Insulin-like growth factor 1 is required for survival of transit-amplifying neuroblasts and differentiation of otic neurons. Camarero, G , Leon, Y , Gorospe, I , De Pablo, F, Alsina, B, Giraldez, F , Varela-Nieto, I . Dev. Biol. - 262 (2) : 242-253 (PMID: 14550788)
1 Aug | 2003 Cell death in the nervous system: lessons from insulin and insulin-like growth factors. Varela-Nieto, I , de la Rosa, EJ, Valenciano, AI, León, Y . Mol. Neurobiol. - 28 (1) : 23-50 (PMID: 14514984) (doi:10.1385/MN:28:1:23)
1 Feb | 2003 Programmed cell death in the developing inner ear is balanced by nerve growth factor and insulin-like growth factor I. Frago, LM , Cañón, S , de la Rosa, EJ, León, Y , Varela-Nieto, I . J. Cell. Sci. - 116 (Pt 3) : 475-486 (PMID: 12508109)
30 Oct | 2002 Expression and function of phospholipase A(2) in brain. Balboa, MA, Varela-Nieto, I , Killermann Lucas, K, Dennis, EA. FEBS Lett. - 531 (1) : 12-17 (PMID: 12401195)
1 Aug | 2002 Cochlear abnormalities in insulin-like growth factor-1 mouse mutants. Camarero, G , Villar, MA, Contreras, J , Fernández-Moreno, C, Pichel, JG, Avendaño, C, Varela-Nieto, I . Hear. Res. - 170 (1-2) : 2-11 (PMID: 12208536)
21 Jun | 2002 Liver cell proliferation requires methionine adenosyltransferase 2A mRNA up-regulation. Pañeda, C , Gorospe, I , Herrera, B, Nakamura, T, Fabregat, I, Varela-Nieto, I . Hepatology - 35 (6) : 1381-1391 (PMID: 12029623) (doi:10.1053/jhep.2002.32538)
5 Apr | 2002 Serum deprivation increases ceramide levels and induces apoptosis in undifferentiated HN9.10e cells. Colombaioni, L, Frago, LM , Varela-Nieto, I , Pesi, R, Garcia-Gil, M. Neurochem. Int. - 40 (4) : 327-336 (PMID: 11792463)
1 Oct | 2001 Delayed inner ear maturation and neuronal loss in postnatal Igf-1-deficient mice. Camarero, G , Avendano, C, Fernandez-Moreno, C, Villar, A, Contreras, J , de Pablo, F, Pichel, JG, Varela-Nieto, I . J. Neurosci. - 21 (19) : 7630-7641 (PMID: 11567053)
1 Jul | 2001 Purification and characterization of insulin-mimetic inositol phosphoglycan-like molecules from grass pea (Lathyrus sativus) seeds. Pañeda, C , Villar, AV, Alonso, A, Goñi, FM, Varela, F, Brodbeck, U, León, Y , Varela-Nieto, I , Jones, DR. Mol. Med. - 7 (7) : 454-460 (PMID: 11683370)
1 Feb | 2001 Short-chain ceramide regulates hepatic methionine adenosyltransferase expression. Frago, LM , Pañeda, C , Fabregat, I, Varela-Nieto, I . J. Hepatol. - 34 (2) : 192-201 (PMID: 11281546)
1 May | 2000 c-Raf regulates cell survival and retinal ganglion cell morphogenesis during neurogenesis. Pimentel, B, Sanz, C , Varela-Nieto, I , Rapp, UR, De Pablo, F, de La Rosa, EJ. J. Neurosci. - 20 (9) : 3254-3262 (PMID: 10777790)
1 Apr | 2000 Role of diffusible and transcription factors in inner ear development: implications in regeneration. Frago, LM , Camerero, G, Cañón, S, Pañeda, C , Sanz, C , Leon, Y , Giraldez, F , Varela-Nieto, I . Histol. Histopathol. - 15 (2) : 657-666 (PMID: 10809387)
1 Nov | 1999 Pattern of expression of the jun family of transcription factors during the early development of the inner ear: implications in apoptosis. Sanz, C , León, Y , Cañón, S, Alvarez, L , Giraldez, F , Varela-Nieto, I . J. Cell. Sci. - 112 ( Pt 22) : 3967-3974 (PMID: 10547357)
20 Aug | 1999 Towards the in vitro reconstitution of caveolae. Asymmetric incorporation of glycosylphosphatidylinositol (GPI) and gangliosides into liposomal membranes. Villar, AV, Alonso, A, Pañeda, C , Varela-Nieto, I , Brodbeck, U, Goñi, FM. FEBS Lett. - 457 (1) : 71-74 (PMID: 10486566)
1 Aug | 1999 Diabetes and the role of inositol-containing lipids in insulin signaling. Jones, DR, Varela-Nieto, I . Mol. Med. - 5 (8) : 505-514 (PMID: 10501653)
29 Jul | 1999 Introduction to structural and functional studies on nerve growth factor. Varela-Nieto, I , Silos-Santiago, I. Microsc. Res. Tech. - 45 (4-5) : 206 (PMID: 10383111) (doi:10.1002/(SICI)1097-0029(19990515/01)45:4/5<206::AID-JEMT2>3.0.CO;2-I)
22 Jun | 1999 Involvement of insulin-like growth factor-I in inner ear organogenesis and regeneration. León, Y , Sanz, C , Frago, LM , Camarero, G , Cañón, S, Varela-Nieto, I , Giráldez, F. Horm. Metab. Res. - 31 (2-3) : 126-132 (PMID: 10226792)
14 Jan | 1999 Strict regulation of c-Raf kinase levels is required for early organogenesis of the vertebrate inner ear. Sanz, C , León, Y , Troppmair, J, Rapp, UR, Varela-Nieto, I . Oncogene - 18 (2) : 429-437 (PMID: 9927199) (doi:10.1038/sj.onc.1202312)
1 Dec | 1998 Glycosyl phosphatidylinositol (GPI)/inositolphosphate glycan (IPG): an intracellular signalling system involved in the control of thyroid cell proliferation. Petitfrere, E, Sartelet, H, Vivien, D, Varela-Nieto, I , Elbtaouri, H, Martiny, L, Haye, B. Biochimie - 80 (12) : 1063-1067 (PMID: 9924986)
31 Aug | 1998 Induction of cell growth by insulin and insulin-like growth factor-I is associated with Jun expression in the otic vesicle. León, Y , Sanz, C , Giráldez, F, Varela-Nieto, I . J. Comp. Neurol. - 398 (3) : 323-332 (PMID: 9714146)
7 Aug | 1998 Phospholipase cleavage of glycosylphosphatidylinositol reconstituted in liposomal membranes. Villar, AV, Goñi, FM, Alonso, A, Jones, DR, León, Y , Varela-Nieto, I . FEBS Lett. - 432 (3) : 150-154 (PMID: 9720914)
24 Apr | 1998 Pattern of methionine adenosyltransferase isoenzyme expression during rat liver regeneration after partial hepatectomy. Frago, LM , Giménez, A, Rodriguez, EN , Varela-Nieto, I . FEBS Lett. - 426 (3) : 305-308 (PMID: 9600256)
1 Mar | 1998 Nerve growth factor and ceramides modulate cell death in the early developing inner ear. Frago, LM , León, Y , de la Rosa, EJ, Gómez-Muñoz, A, Varela-Nieto, I . J. Cell. Sci. - 111 ( Pt 5) : 549-556 (PMID: 9454729)
1 Mar | 1998 The role of glycosyl-phosphatidylinositol in signal transduction. Jones, DR, Varela-Nieto, I . Int. J. Biochem. Cell Biol. - 30 (3) : 313-326 (PMID: 9611774)
1 Aug | 1997 Isolation and partial characterisation of insulin-mimetic inositol phosphoglycans from human liver. Caro, HN, Kunjara, S, Rademacher, TW, León, Y , Jones, DR, Avila, MA, Varela-Nieto, I . Biochem. Mol. Med. - 61 (2) : 214-228 (PMID: 9259987)
15 Jul | 1997 Stimulation of DNA synthesis by natural ceramide 1-phosphate. Gomez-Muñoz, A, Frago, LM , Alvarez, L , Varela-Nieto, I . Biochem. J. - 325 ( Pt 2) : 435-440 (PMID: 9230125)
17 Apr | 1997 Glycosyl-phosphatidylinositol-phospholipase type D: a possible candidate for the generation of second messengers. Jones, DR, Avila, MA, Sanz, C , Varela-Nieto, I . Biochem. Biophys. Res. Commun. - 233 (2) : 432-437 (PMID: 9144552)
1 Feb | 1997 Inositol-phosphoglycan inhibits calcium oscillations in hepatocytes by reducing calcium entry. Sanchez-Bueno, A, Greenwood, MR, Varela-Nieto, I , Marrero, I, Gil, B, Mato, JM , Cobbold, PH. Cell Calcium - 21 (2) : 125-133 (PMID: 9132295)
1 Feb | 1997 Neural cell adhesion molecule expression in the developing chick otic vesicle. Leon, Y , Varela-Nieto, I , Breen, KC. Biochem. Soc. Trans. - 25 (1) : 10S (PMID: 9056908)
1 Oct | 1996 Cell signalling by inositol phosphoglycans from different species. Varela-Nieto, I , León, Y , Caro, HN. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. - 115 (2) : 223-241 (PMID: 8939003)
1 Jul | 1996 Role of Raf kinases during inner ear development. Sanz, C , Leon, Y , Garcia-Gil, M, Varela-Nieto, I . Int. J. Dev. Biol. - Suppl 1 : 83S-84S (PMID: 9087707)
1 Aug | 1995 Insulin-like growth factor-I regulates cell proliferation in the developing inner ear, activating glycosyl-phosphatidylinositol hydrolysis and Fos expression. León, Y , Vazquez, E, Sanz, C , Vega, JA, Mato, JM , Giraldez, F , Represa, J, Varela-Nieto, I . Endocrinology - 136 (8) : 3494-3503 (PMID: 7628386) (doi:10.1210/endo.136.8.7628386)
1 May | 1995 Intracellular mediators of insulin-like growth factor I during otic vesicle development. Leon, Y , Sanz, C , Varela-Nieto, I . Biochem. Soc. Trans. - 23 (2) : 185S (PMID: 7672208)
1 May | 1995 Role of glycosyl-phosphatidylinositol hydrolysis as a mitogenic signal for epidermal growth factor. Clemente, R, Jones, DR, Ochoa, P , Romero, G, Mato, JM , Varela-Nieto, I . Cell. Signal. - 7 (4) : 411-421 (PMID: 8527310)
1 May | 1995 Signalling at the epidermal growth factor receptor: role of glycosylphosphatidylinositol hydrolysis. Jones, DR, Clemente, R, Varela-Nieto, I . Biochem. Soc. Trans. - 23 (2) : 174S (PMID: 7672200)
1 Nov | 1994 Synthesis and investigation of the possible insulin-like activity of 1D-4-O- and 1D-6-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-myo-inositol 1-phosphate and 1D-6-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-myo-inositol 1,2-(cyclic phosphate). Zapata, A, León, Y , Mato, JM , Varela-Nieto, I , Penadés, S, Martín-Lomas, M. Carbohydr. Res. - 264 (1) : 21-31 (PMID: 8001018)
1 Feb | 1994 Mannosamine is an unspecific inhibitor of glycosyl-phosphatidylinositol biosynthesis in T-lymphocytes. Avila, MA, Clemente, R, Varela-Nieto, I . Biochem. Soc. Trans. - 22 (1) : 11S (PMID: 8206201)
1 Sep | 1993 Brain-derived neurotrophic factor and neurotrophin-3 induce cell proliferation in the cochleovestibular ganglion through a glycosyl-phosphatidylinositol signaling system. Represa, J, Avila, MA, Romero, G, Mato, JM , Giraldez, F , Varela-Nieto, I . Dev. Biol. - 159 (1) : 257-265 (PMID: 8365564) (doi:10.1006/dbio.1993.1238)
1 Sep | 1993 Brain-derived neurotrophic factor and neurotrophin-3 support the survival and neuritogenesis response of developing cochleovestibular ganglion neurons. Avila, MA, Varela-Nieto, I , Romero, G, Mato, JM , Giraldez, F , Van De Water, TR, Represa, J. Dev. Biol. - 159 (1) : 266-275 (PMID: 8365565) (doi:10.1006/dbio.1993.1239)
2 Jun | 1992 Role of the glycosylphosphatidylinositol/inositol phosphoglycan system in human fibroblast proliferation. Vasta, V, Bruni, P, Clemente, R, Vannini, F, Ochoa, P , Romero, G, Farnararo, M, Varela-Nieto, I . Exp. Cell Res. - 200 (2) : 439-443 (PMID: 1374038)
15 Mar | 1992 A phosphatidylinositol-linkage-deficient T-cell mutant contains insulin-sensitive glycosyl-phosphatidylinositol. Avila, MA, Clemente, R, Varela-Nieto, I . Biochem. J. - 282 ( Pt 3) : 681-686 (PMID: 1532490)
31 Oct | 1991 An inositol phosphoglycan stimulates glycolysis in human platelets. Bruni, P, Vasta, V, Berti, L, Avila, MA, Farnararo, M, Varela-Nieto, I . Biochem. Biophys. Res. Commun. - 180 (2) : 1041-1047 (PMID: 1835382)
15 Sep | 1991 Glycosyl-phosphatidylinositol/inositol phosphoglycan: a signaling system for the low-affinity nerve growth factor receptor. Represa, J, Avila, MA, Miner, C, Giraldez, F , Romero, G, Clemente, R, Mato, JM , Varela-Nieto, I . Proc. Natl. Acad. Sci. U.S.A. - 88 (18) : 8016-8019 (PMID: 1654553)
1 Aug | 1991 Insulin-like effects of inositol phosphate-glycan on messenger RNA expression in rat hepatocytes. Alvarez, L , Avila, MA, Mato, JM , Castaño, JG , Varela-Nieto, I . Mol. Endocrinol. - 5 (8) : 1062-1068 (PMID: 1719385) (doi:10.1210/mend-5-8-1062)
1 Feb | 1991 Inositol phospho-oligosaccharide stimulates cell proliferation in the early developing inner ear. Varela-Nieto, I , Represa, J, Avila, MA, Miner, C, Mato, JM , Giraldez, F . Dev. Biol. - 143 (2) : 432-435 (PMID: 1991566)
12 Dec | 1985 Modulation by the ratio S-adenosylmethionine/S-adenosylhomocysteine of cyclic AMP-dependent phosphorylation of the 50 kDa protein of rat liver phospholipid methyltransferase. Villalba, M, Varela, I , Mérida, I, Pajares, MA , Martínez del Pozo, A, Mato, JM . Biochim. Biophys. Acta - 847 (3) : 273-279 (PMID: 2998482)
1 Oct | 1984 Purification and photoaffinity labelling of lipid methyltransferase from rat liver. Pajares, MA , Alemany, S , Varela, I , Marin Cao, D, Mato, JM . Biochem. J. - 223 (1) : 61-66 (PMID: 6497846)
16 Aug | 1984 Activation of partially purified rat liver lipid methyltransferase by phosphorylation. Varela, I , Mérida, I, Pajares, M , Villalba, M, Mato, JM . Biochem. Biophys. Res. Commun. - 122 (3) : 1065-1070 (PMID: 6332623)
15 Oct | 1983 [Hormonal regulation of the synthesis of phosphatidylcholine by transmethylation]. Mato, JM , Alvarez Chiva, V, Marín Cao, D, Varela, I , García Gil, M, Alemany, S . Rev Clin Esp - 171 (1) : 7-10 (PMID: 6658087)
15 Nov | 1982 Inhibition of phosphatidylcholine synthesis by vasopressin and angiotensin in rat hepatocytes. Alemany, S , Varela, I , Mato, JM . Biochem. J. - 208 (2) : 453-457 (PMID: 6818955)
25 Aug | 1982 Calmodulin regulation of phospholipid and fatty acid methylation by rat liver microsomes. Alemany, S , Varela, I , Harper, JF, Mato, JM . J. Biol. Chem. - 257 (16) : 9249-9251 (PMID: 6809733)
30 Nov | 1981 Stimulation by vasopressin and angiotensin of phospholipid methyltransferase in isolated rat hepatocytes. Alemany, S , Varela, I , Mato, JM . FEBS Lett. - 135 (1) : 111-114 (PMID: 6797839)