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spacerTrabajos Publicados por Mario Vallejo Fdez. de la Reguera
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  1. Mirasierra, M.; Fernández-Pérez, A.; Lizarbe, B.; Keiran, N.; Ruiz-Cañas, L.; Casarejos, M.J.; Cerdán, S.; Vendrell, J.; Fernández-Veledo, S.; Vallejo, M. "Alx3 deficiency disrupts energy homeostasis, alters body composition, and impairs hypothalamic regulation of food intake.". Cell Mol Life Sci. 81(1): 343. (2024). (PMID: 39129011).
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  2. Villanueva-Carmona, T.; Cedó, L.; Madeira, A.; Ceperuelo-Mallafré, V.; Rodríguez-Peña, M.M.; Núñez-Roa, C.; Maymó-Masip, E.; Repollés-de-Dalmau, M.; Badia, J.; Keiran, N.; Mirasierra, M.; Pimenta-Lopes, C.; Sabadell-Basallote, J.; Bosch, R.; Caubet, L.; Escolà-Gil, J.C.; Fernández-Real, J.M.; Vilarrasa, N.; Ventura, F.; Vallejo, M.; Vendrell, J.; Fernández-Veledo, S. "SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression.". Cell Metab. (): . (2023). (PMID: 36977414).
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  3. Fernández-Pérez, A.; Sanz-Magro, A.; Moratalla, R.; Vallejo, M. "Restricting feeding to dark phase fails to entrain circadian activity and energy expenditure oscillations in Pitx3-mutant Aphakia mice.". Cell Rep. 38(2): 110241. (2022). (PMID: 35021074).
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  4. Grajales, D.; Vázquez, P.; Ruíz-Rosario, M.; Tudurí, E.; Mirasierra, M.; Ferreira, V.; Hitos, A.B.; Koller, D.; Zubiaur, P.; Cigudosa, J.C.; Abad-Santos, F.; Vallejo, M.; Quesada, I.; Tirosh, B.; Leibowitz, G.; Valverde, Á.M. "The second-generation antipsychotic drug aripiprazole modulates the serotonergic system in pancreatic islets and induces beta cell dysfunction in female mice.". Diabetologia. (): . (2021). (PMID: 34932133).
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  5. Díaz-Catalán, D.; Alcarraz-Vizán, G.; Castaño, C.; de Pablo, S.; Rodríguez-Comas, J.; Fernández-Pérez, A.; Vallejo, M.; Ramírez, S.; Claret, M.; Parrizas, M.; Novials, A.; Servitja, J.M. "BACE2 suppression in mice aggravates the adverse metabolic consequences of an obesogenic diet.". Mol Metab. (): 101251. (2021). (PMID: 34015524).
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  6. Arcones, A.C.; Vila-Bedmar, R.; Mirasierra, M.; Cruces-Sande, M.; Vallejo, M.; Jones, B.; Tomas, A.; Mayor, F.; Murga, C. "GRK2 regulates GLP-1R-mediated early phase insulin secretion in vivo.". BMC Biol. 19(1): 40. (2021). (PMID: 33658023).
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  7. Ribo, S.; Sánchez-Infantes, D.; Martinez-Guino, L.; García-Mantrana, I.; Ramon-Krauel, M.; Tondo, M.; Arning, E.; Nofrarías, M.; Osorio-Conles, Ó.; Fernández-Pérez, A.; González-Torres, P.; Cebrià, J.; Gavaldà-Navarro, A.; Chenoll, E.; Isganaitis, E.; Villarroya, F.; Vallejo, M.; Segalés, J.; Jiménez-Chillarón, J.C.; Bottiglieri, T.; Demerath, E.W.; Fields, D.A.; Collado, M.C.; Lerin, C. "Increasing breast milk betaine modulates Akkermansia abundance in mammalian neonates and improves long-term metabolic health.". Sci Transl Med. 13(587): . (2021). (PMID: 33790021).
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  8. Ribas-Aulinas, F.; Ribo, S.; Parra-Vargas, M.; Fernández-Pérez, A.; Cebrià, J.; Guardiola-Perello, M.; Ramon-Krauel, M.; Lerin, C.; Diaz, R.; Kalko, S.G.; Vallejo, M.; Díez-Noguera, A.; Cambras, T.; Jimenez-Chillaron, J.C. "Neonatal overfeeding during lactation rapidly and permanently misaligns the hepatic circadian rhythm and programmes adult NAFLD.". Mol Metab. (): 101162. (2021). (PMID: 33422644).
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  9. Castaño, C.; Mirasierra, M.; Vallejo, M.; Novials, A.; Párrizas, M. "Delivery of muscle-derived exosomal miRNAs induced by HIIT improves insulin sensitivity through down-regulation of hepatic FoxO1 in mice.". Proc Natl Acad Sci U S A. (): . (2020). (PMID: 33199621).
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  10. Murillo-Cuesta, S.; Artuch, R.; Asensio, F.; de la Villa, P.; Dierssen, M.; Enríquez, J.A.; Fillat, C.; Fourcade, S.; Ibáñez, B.; Montoliu, L.; Oliver, E.; Pujol, A.; Salido, E.; Vallejo, M.; Varela-Nieto, I. "The Value of Mouse Models of Rare Diseases: A Spanish Experience.". Front Genet. 11(): 583932. (2020). (PMID: 33173540).
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  11. Pérez-Taboada, I.; Alberquilla, S.; Martín, E.D.; Anand, R.; Vietti-Michelina, S.; Tebeka, N.N.; Cantley, J.; Cragg, S.J.; Moratalla, R.; Vallejo, M. "Diabetes Causes Dysfunctional Dopamine Neurotransmission Favoring Nigrostriatal Degeneration in Mice.". Mov. Disord.. (): . (2020). (PMID: 32666590).
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  12. Ràfols, P.; Heijs, B.; Del Castillo, E.; Yanes, O.; McDonnell, L.A.; Brezmes, J.; Pérez-Taboada, I.; Vallejo, M.; García-Altares, M.; Correig, X. "rMSIproc: an R package for mass spectrometry imaging data processing.". Bioinformatics. (): . (2020). (PMID: 32108859).
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  13. Del Río-Martín, A.; Pérez-Taboada, I.; Fernández-Pérez, A.; Moratalla, R.; de la Villa, P.; Vallejo, M. "Hypomorphic Expression of Pitx3 Disrupts Circadian Clocks and Prevents Metabolic Entrainment of Energy Expenditure.". Cell Rep. 29(11): 3678-3692.e4. (2019). (PMID: 31825844).
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  14. Lizarbe, B.; Fernández-Pérez, A.; Caz, V.; Largo, C.; Vallejo, M.; López-Larrubia, P.; Cerdán, S. "Systemic Glucose Administration Alters Water Diffusion and Microvascular Blood Flow in Mouse Hypothalamic Nuclei - An fMRI Study.". Front Neurosci. 13(): 921. (2019). (PMID: 31551685).
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  15. Ramon-Krauel, M.; Pentinat, T.; Bloks, V.W.; Cebrià, J.; Ribo, S.; Pérez-Wienese, R.; Vilà, M.; Palacios-Marin, I.; Fernández-Pérez, A.; Vallejo, M.; Téllez, N.; Rodríguez, M.À.; Yanes, O.; Lerin, C.; Díaz, R.; Plosch, T.; Tietge, U.J.F.; Jimenez-Chillaron, J.C. "Epigenetic programming at the Mogat1 locus may link neonatal overnutrition with long-term hepatic steatosis and insulin resistance.". FASEB J.. (): fj201700717RR. (2018). (PMID: 29812971).
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  16. García-Sanz, P.; Mirasierra, M.; Moratalla, R.; Vallejo, M. "Embryonic defence mechanisms against glucose-dependent oxidative stress require enhanced expression of Alx3 to prevent malformations during diabetic pregnancy.". Sci Rep. 7(1): 389. (2017). (PMID: 28341857).
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  17. Molinero, A.; Fernandez-Perez, A.; Mogas, A.; Giralt, M.; Comes, G.; Fernandez-Gayol, O.; Vallejo, M.; Hidalgo, J. "Role of muscle IL-6 in gender-specific metabolism in mice.". PLoS ONE. 12(3): e0173675. (2017). (PMID: 28319140).
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  18. Mallarino, R.; Henegar, C.; Mirasierra, M.; Manceau, M.; Schradin, C.; Vallejo, M.; Beronja, S.; Barsh, G.S.; Hoekstra, H.E. "Developmental mechanisms of stripe patterns in rodents.". Nature. 539(7630): 518-523. (2016). (PMID: 27806375).
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  19. Mirasierra, M.; Vallejo, M. "Glucose-dependent downregulation of glucagon gene expression mediated by selective interactions between ALX3 and PAX6 in mouse alpha cells.". Diabetologia. 59(4): 766-775. (2016). (PMID: 26739814).
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  20. Ruiz-DeDiego, I.; Mellstrom, B.; Vallejo, M.; Naranjo, J.R.; Moratalla, R. "Activation of DREAM (downstream regulatory element antagonistic modulator), a calcium-binding protein, reduces L-DOPA-induced dyskinesias in mice.". Biol. Psychiatry. 77(2): 95-9105. (2015). (PMID: 24857398).
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  21. Fernández-Pérez, A.; Vallejo, M. "Pdx1 and USF transcription factors co-ordinately regulate Alx3 gene expression in pancreatic β-cells.". Biochem. J.. 463(2): 287-296. (2014). (PMID: 25040025).
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  22. García-Sanz, P.; Fernández-Pérez, A.; Vallejo, M. "Differential configurations involving binding of USF transcription factors and Twist1 regulate Alx3 promoter activity in mesenchymal and pancreatic cells.". Biochem. J.. 450(1): 199-208. (2013). (PMID: 23181698).
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  23. González-Rodríguez, A.; Más-Gutierrez, J.A.; Mirasierra, M.; Fernandez-Pérez, A.; Lee, Y.J.; Ko, H.J.; Kim, J.K.; Romanos, E.; Carrascosa, J.M.; Ros, M.; Vallejo, M.; Rondinone, C.M.; Valverde, A.M. "Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging.". Aging Cell. 11(2): 284-296. (2012). (PMID: 22221695).
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  24. Vallejo, M. "The aristaless-like homeobox protein Alx3 as an etiopathogenic factor for diabetes mellitus.". Islets. 3(2): 66-68. (2011). (PMID: 21350340).
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  25. Mirasierra, M.; Fernández-Pérez, A.; Díaz-Prieto, N.; Vallejo, M. "Alx3-deficient mice exhibit decreased insulin in beta cells, altered glucose homeostasis and increased apoptosis in pancreatic islets.". Diabetologia. 54(2): 403-414. (2011). (PMID: 21104068).
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  26. Sánchez-Muñoz, I.; Sánchez-Franco, F.; Vallejo, M.; Fernández-Pérez, A.; Palacios, N.; Fernández, M.; Sánchez-Grande, M.; Cacicedo, L. "Regulation of somatostatin gene expression by brain derived neurotrophic factor in fetal rat cerebrocortical cells.". Brain Res.. 1375(): 28-40. (2011). (PMID: 21184749).
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  27. Lakhwani, S.; García-Sanz, P.; Vallejo, M. "Alx3-deficient mice exhibit folic acid-resistant craniofacial midline and neural tube closure defects.". Dev. Biol.. 344(2): 869-880. (2010). (PMID: 20534379).
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  28. Sánchez-Muñoz, I.; Sánchez-Franco, F.; Vallejo, M.; Fernández-Pérez, A.; Palacios, N.; Fernández, M.; Cacicedo, L. "Activity-dependent somatostatin gene expression is regulated by cAMP-dependent protein kinase and Ca2+-calmodulin kinase pathways.". J. Neurosci. Res.. 88(4): 825-836. (2010). (PMID: 19859966).
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  29. Vallejo, M. "PACAP signaling to DREAM: a cAMP-dependent pathway that regulates cortical astrogliogenesis.". Mol. Neurobiol.. 39(2): 90-9100. (2009). (PMID: 19238593).
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  30. Lastres-Becker, I.; Fernández-Pérez, A.; Cebolla, B.; Vallejo, M. "Pituitary adenylate cyclase-activating polypeptide stimulates glial fibrillary acidic protein gene expression in cortical precursor cells by activating Ras and Rap1.". Mol. Cell. Neurosci.. 39(3): 291-301. (2008). (PMID: 18707003).
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  31. Cebolla, B.; Fernández-Pérez, A.; Perea, G.; Araque, A.; Vallejo, M. "DREAM mediates cAMP-dependent, Ca2+-induced stimulation of GFAP gene expression and regulates cortical astrogliogenesis.". J. Neurosci.. 28(26): 6703-6713. (2008). (PMID: 18579744).
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  32. Mirasierra, M.; Vallejo, M. "The homeoprotein Alx3 expressed in pancreatic beta-cells regulates insulin gene transcription by interacting with the basic helix-loop-helix protein E47.". Mol. Endocrinol.. 20(11): 2876-2889. (2006). (PMID: 16825292).
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  33. Cebolla, B.; Vallejo, M. "Nuclear factor-I regulates glial fibrillary acidic protein gene expression in astrocytes differentiated from cortical precursor cells.". J. Neurochem.. 97(4): 1057-1070. (2006). (PMID: 16606365).
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  34. Pérez-Villamil, B.; Mirasierra, M.; Vallejo, M. "The homeoprotein Alx3 contains discrete functional domains and exhibits cell-specific and selective monomeric binding and transactivation.". J. Biol. Chem.. 279(36): 38062-38071. (2004). (PMID: 15226305).
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  35. Vallejo, I.; Vallejo, M. "Pituitary adenylate cyclase-activating polypeptide induces astrocyte differentiation of precursor cells from developing cerebral cortex.". Mol. Cell. Neurosci.. 21(4): 671-683. (2002). (PMID: 12504599).
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  36. Beranova, M.; Oliveira, L.M.; Bédécarrats, G.Y.; Schipani, E.; Vallejo, M.; Ammini, A.C.; Quintos, J.B.; Hall, J.E.; Martin, K.A.; Hayes, F.J.; Pitteloud, N.; Kaiser, U.B.; Crowley, W.F.; Seminara, S.B. "Prevalence, phenotypic spectrum, and modes of inheritance of gonadotropin-releasing hormone receptor mutations in idiopathic hypogonadotropic hypogonadism.". J. Clin. Endocrinol. Metab.. 86(4): 1580-1588. (2001). (PMID: 11297587).
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  37. Oliveira, L.M.; Seminara, S.B.; Beranova, M.; Hayes, F.J.; Valkenburgh, S.B.; Schipani, E.; Costa, E.M.; Latronico, A.C.; Crowley, W.F.; Vallejo, M. "The importance of autosomal genes in Kallmann syndrome: genotype-phenotype correlations and neuroendocrine characteristics.". J. Clin. Endocrinol. Metab.. 86(4): 1532-1538. (2001). (PMID: 11297579).
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  38. Zulewski, H.; Abraham, E.J.; Gerlach, M.J.; Daniel, P.B.; Moritz, W.; Müller, B.; Vallejo, M.; Thomas, M.K.; Habener, J.F. "Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes.". Diabetes. 50(3): 521-533. (2001). (PMID: 11246871).
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  39. Schwartz, P.T.; Perez-Villamil, B.; Rivera, A.; Moratalla, R.; Vallejo, M. "Pancreatic homeodomain transcription factor IDX1/IPF1 expressed in developing brain regulates somatostatin gene transcription in embryonic neural cells.". J. Biol. Chem.. 275(25): 19106-19114. (2000). (PMID: 10751390).
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  40. McManus, M.F.; Chen, L.C.; Vallejo, I.; Vallejo, M. "Astroglial differentiation of cortical precursor cells triggered by activation of the cAMP-dependent signaling pathway.". J. Neurosci.. 19(20): 9004-9015. (1999). (PMID: 10516318).
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  41. Perez-Villamil, B.; Schwartz, P.T.; Vallejo, M. "The pancreatic homeodomain transcription factor IDX1/IPF1 is expressed in neural cells during brain development.". Endocrinology. 140(8): 3857-3860. (1999). (PMID: 10433248).
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  42. Schwartz, P.T.; Vallejo, M. "Differential regulation of basal and cyclic adenosine 3',5'-monophosphate-induced somatostatin gene transcription in neural cells by DNA control elements that bind homeodomain proteins.". Mol. Endocrinol.. 12(9): 1280-1293. (1998). (PMID: 9731698).
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Instituto de Investigaciones Biomédicas "Alberto Sols"
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