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PUBLICACIONES

 

 

spacerTrabajos Publicados por María Antonia Günther Nonell
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  1. Günther Sillero, M.A.; de Diego, A.; Sillero, A. "Methylenebisphosphonate and triphosphate derivatives of the mevalonate pathway are substrates of yeast UTP:glucose-1-phosphate uridylyltransferase.". Biochimie. 94(9): 1871-1875. (2012). (PMID: 22580055).
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  2. Pérez-Zúñiga, F.J.; Günther Sillero, M.A.; Sillero, A. "Bisphosphonates activate the 5-fluorouracil/uracil phosphoribosyltransferase activity present in Saccharomyces cerevisiae cell extracts: implications for tumor treatments.". Biochem. Pharmacol.. 76(7): 825-830. (2008). (PMID: 18706399).
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  3. Günther Sillero, M.A.; de Diego, A.; Pérez-Zúñiga, F.J.; Sillero, A. "Synthesis of bisphosphonate derivatives of ATP by T4 DNA ligase, ubiquitin activating enzyme (E1) and other ligases.". Biochem. Pharmacol.. 75(10): 1959-1965. (2008). (PMID: 18378215).
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  4. Günther Sillero, M.A.; Pérez-Zúñiga, F.; Gomes, J.; de Carvalho, A.I.; Martins, S.; Silles, E.; Sillero, A. "Synthesis of FUDP-N-acetylglucosamine and FUDP-glucose in Saccharomyces cerevisiae cells treated with 5-fluorouracil.". FEMS Yeast Res.. 8(2): 257-265. (2008). (PMID: 17995957).
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  5. Sillero, M.A.; de Diego, A.; Silles, E.; Pérez-Zúñiga, F.; Sillero, A. "Synthesis of bisphosphonate derivatives of ATP by T4 RNA ligase.". FEBS Lett.. 580(24): 5723-5727. (2006). (PMID: 17010342).
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  6. Günther Sillero, M.A.; de Diego, A.; Silles, E.; Sillero, A. "Synthesis of (di)nucleoside polyphosphates by the ubiquitin activating enzyme E1.". FEBS Lett.. 579(27): 6223-6229. (2005). (PMID: 16256113).
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  7. Silles, E.; Osorio, H.; Maia, R.; Günther Sillero, M.A.; Sillero, A. "Micromolar HgCl2 concentrations transitorily duplicate the ATP level in Saccharomyces cerevisiae cells.". FEBS Lett.. 579(19): 4044-4048. (2005). (PMID: 16023109).
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  8. Osório, H.; Silles, E.; Maia, R.; Peleteiro, B.; Moradas-Ferreira, P.; Günther Sillero, M.A.; Sillero, A. "Influence of chronological aging on the survival and nucleotide content of Saccharomyces cerevisiae cells grown in different conditions: occurrence of a high concentration of UDP-N-acetylglucosamine in stationary cells grown in 2% glucose.". FEMS Yeast Res. 5(4-5): 387-398. (2005). (PMID: 15691744).
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  9. Osório, H.; Moradas-Ferreira, P.; Günther Sillero, M.A.; Sillero, A. "In Saccharomyces cerevisiae, the effect of H2O2 on ATP, but not on glyceraldehyde-3-phosphate dehydrogenase, depends on the glucose concentration.". Arch. Microbiol.. 181(3): 231-236. (2004). (PMID: 14735298).
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  10. Guranowski, A.; de Diego, A.; Sillero, A.; Günther Sillero, M.A. "Uridine 5'-polyphosphates (p4U and p5U) and uridine(5')polyphospho(5')nucleosides (Up(n)Ns) can be synthesized by UTP:glucose-1-phosphate uridylyltransferase from Saccharomyces cerevisiae.". FEBS Lett.. 561(1-3): 83-88. (2004). (PMID: 15013755).
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  11. Guranowski, A.; Sillero, A.; Günther Sillero, M.A. "Selective splitting of 3'-adenylated dinucleoside polyphosphates by specific enzymes degrading dinucleoside polyphosphates.". Acta Biochim. Pol.. 50(1): 123-130. (2003). (PMID: 12673352).
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  12. Sillero, M.A.; de Diego, A.; Silles, E.; Osorio, H.; Sillero, A. "Polyphosphates strongly inhibit the tRNA dependent synthesis of poly(A) catalyzed by poly(A) polymerase from Saccharomyces cerevisiae.". FEBS Lett.. 550(1-3): 41-45. (2003). (PMID: 12935883).
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  13. Osorio, H.; Carvalho, E.; del Valle, M.; Günther Sillero, M.A.; Moradas-Ferreira, P.; Sillero, A. "H2O2, but not menadione, provokes a decrease in the ATP and an increase in the inosine levels in Saccharomyces cerevisiae. An experimental and theoretical approach.". Eur. J. Biochem.. 270(7): 1578-1589. (2003). (PMID: 12654013).
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  14. Sillero, M.A.; De Diego, A.; Osorio, H.; Sillero, A. "Dinucleoside polyphosphates stimulate the primer independent synthesis of poly(A) catalyzed by yeast poly(A) polymerase.". Eur. J. Biochem.. 269(21): 5323-5329. (2002). (PMID: 12392566).
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  15. Sillero, M.A.; Socorro, S.; Baptista, M.J.; Del Valle, M.; De Diego, A.; Sillero, A. "Poly(A) polymerase from Escherichia coli adenylylates the 3'-hydroxyl residue of nucleosides, nucleoside 5'-phosphates and nucleoside(5')oligophospho(5')nucleosides (NpnN).". Eur. J. Biochem.. 268(12): 3605-3611. (2001). (PMID: 11422392).
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  16. Torrecilla, A.; Marques, A.F.; Buscalioni, R.D.; Oliveira, J.M.; Teixeira, N.A.; Atencia, E.A.; Günther Sillero, M.A.; Sillero, A. "Metabolic fate of AMP, IMP, GMP and XMP in the cytosol of rat brain: an experimental and theoretical analysis.". J. Neurochem.. 76(5): 1291-1307. (2001). (PMID: 11238714).
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  17. Sillero, A.; Sillero, M.A. "Synthesis of dinucleoside polyphosphates catalyzed by firefly luciferase and several ligases.". Pharmacol. Ther.. 87(2-3): 91-9102. (2000). (PMID: 11007993).
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  18. Atencia, E.A.; Montes, M.; Günther Sillero, M.A.; Sillero, A. "Several dinucleoside polyphosphates are acceptor substrates in the T4 RNA ligase catalyzed reaction.". Eur. J. Biochem.. 267(6): 1707-1714. (2000). (PMID: 10712602).
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  19. Atencia, E.A.; Madrid, O.; Günther Sillero, M.A.; Sillero, A. "T4 RNA ligase catalyzes the synthesis of dinucleoside polyphosphates.". Eur. J. Biochem.. 261(3): 802-811. (1999). (PMID: 10215898).
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  20. Fontes, R.; Günther Sillero, M.A.; Sillero, A. "Acyl-CoA synthetase catalyzes the synthesis of diadenosine hexaphosphate (Ap6A).". Biochimie. 81(3): 229-233. (1999). (PMID: 10385004).
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  21. Fontes, R.; Ortiz, B.; de Diego, A.; Sillero, A.; Günther Sillero, M.A. "Dehydroluciferyl-AMP is the main intermediate in the luciferin dependent synthesis of Ap4A catalyzed by firefly luciferase.". FEBS Lett.. 438(3): 190-194. (1998). (PMID: 9827543).
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  22. Marques, A.F.; Teixeira, N.A.; Gambaretto, C.; Sillero, A.; Sillero, M.A. "IMP-GMP 5'-nucleotidase from rat brain: activation by polyphosphates.". J. Neurochem.. 71(3): 1241-1250. (1998). (PMID: 9721750).
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  23. Madrid, O.; Martín, D.; Atencia, E.A.; Sillero, A.; Günther Sillero, M.A. "T4 DNA ligase synthesizes dinucleoside polyphosphates.". FEBS Lett.. 433(3): 283-286. (1998). (PMID: 9744812).
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  24. Fontes, R.; Sillero, M.A.; Sillero, A. "Acyl coenzyme A synthetase from Pseudomonas fragi catalyzes the synthesis of adenosine 5'-polyphosphates and dinucleoside polyphosphates.". J. Bacteriol.. 180(12): 3152-3158. (1998). (PMID: 9620965).
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  25. Fontes, R.; Dukhovich, A.; Sillero, A.; Sillero, M.A. "Synthesis of dehydroluciferin by firefly luciferase: effect of dehydroluciferin, coenzyme A and nucleoside triphosphates on the luminescent reaction.". Biochem. Biophys. Res. Commun.. 237(2): 445-450. (1997). (PMID: 9268731).
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  26. Sillero, M.A.; Madrid, O.; Zaera, E.; Sillero, A. "2',3'-dideoxynucleoside triphosphates (ddNTP) and di-2',3'-dideoxynucleoside tetraphosphates (ddNp4ddN) behave differently to the corresponding NTP and Np4N counterparts as substrates of firefly luciferase, dinucleoside tetraphosphatase and phosphodiesterases.". Biochim. Biophys. Acta. 1334(2-3): 191-199. (1997). (PMID: 9101713).
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  27. Dukhovich, A.; Sillero, A.; Sillero, M.A. "Time course of luciferyl adenylate synthesis in the firefly luciferase reaction.". FEBS Lett.. 395(2-3): 188-190. (1996). (PMID: 8898092).
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  28. Garrido, S.; Zaera, E.; Torrecilla, A.; Sillero, A.; Günther Sillero, M.A. "Labeled adenosine(5')tetraphospho(5')adenosine (Ap4A) and adenosine(5')tetraphospho(5')nucleoside (Ap4N). Synthesis with firefly luciferase.". J. Biochem. Biophys. Methods. 30(2-3): 191-198. (1995). (PMID: 7494096).
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  29. Guranowski, A.; Starzyńska, E.; Günther Sillero, M.A.; Sillero, A. "Conversion of adenosine(5') oligophospho(5') adenosines into inosine(5') oligophospho(5') inosines by non-specific adenylate deaminase from the snail Helix pomatia.". Biochim. Biophys. Acta. 1243(1): 78-84. (1995). (PMID: 7827111).
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  30. Sillero, M.A.; Del Valle, M.; Zaera, E.; Michelena, P.; García, A.G.; Sillero, A. "Diadenosine 5',5"-P1,P4-tetraphosphate (Ap4A), ATP and catecholamine content in bovine adrenal medulla, chromaffin granules and chromaffin cells.". Biochimie. 76(5): 404-409. (1994). (PMID: 7849106).
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  31. Bleisch, S.; Sillero, M.A.; Torrecilla, A.; Sillero, A. "Uric acid synthesis by rat liver supernatants from purine bases, nucleosides and nucleotides. Effect of allopurinol.". Cell Biochem. Funct.. 12(4): 237-245. (1994). (PMID: 7834812).
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  32. Guranowski, A.; Günther Sillero, M.A.; Sillero, A. "Adenosine 5'-tetraphosphate and adenosine 5'-pentaphosphate are synthesized by yeast acetyl coenzyme A synthetase.". J. Bacteriol.. 176(10): 2986-2990. (1994). (PMID: 7910605).
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  33. Sillero, A.; Sillero, M.A.; Hernandorena, A. "Effect of diets containing adenosine, guanosine, inosine or xanthosine on the nucleotide content of Artemia. Influence of mycophenolic acid.". Cell Biochem. Funct.. 11(3): 193-200. (1993). (PMID: 8403233).
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  34. Ortiz, B.; Sillero, A.; Günther Sillero, M.A. "Specific synthesis of adenosine(5')tetraphospho(5')nucleoside and adenosine(5')oligophospho(5')adenosine (n > 4) catalyzed by firefly luciferase.". Eur. J. Biochem.. 212(1): 263-270. (1993). (PMID: 8444160).
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  35. Castillo, C.J.; Moro, M.A.; Del Valle, M.; Sillero, A.; García, A.G.; Sillero, M.A. "Diadenosine tetraphosphate is co-released with ATP and catecholamines from bovine adrenal medulla.". J. Neurochem.. 59(2): 723-732. (1992). (PMID: 1629742).
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  36. Sillero, M.A.; Guranowski, A.; Sillero, A. "Synthesis of dinucleoside polyphosphates catalyzed by firefly luciferase.". Eur. J. Biochem.. 202(2): 507-513. (1991). (PMID: 1761051).
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  37. Guranowski, A.; Starzyńska, E.; Rataj-Guranowska, M.; Günther Sillero, M.A. "Purification of apyrase from yellow lupin cotyledons after extraction with perchloric acid.". Protein Expr. Purif.. 2(4): 235-239. (1991). (PMID: 1668272).
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  38. García-Agúndez, J.; Cameselle, J.C.; Costas, M.J.; Sillero, M.A.; Sillero, A. "Particulate diadenosine 5',5"'-P1,P3-triphosphate hydrolases in rat brain: two specific dinucleoside triphosphatases and two phosphodiesterase I-like hydrolases.". Biochim. Biophys. Acta. 1073(2): 402-409. (1991). (PMID: 1849011).
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  39. Wasternack, C.; Günther Sillero, M.A.; Sillero, A. "Diadenosine polyphosphates inhibit the action of ribonucleotide reductase on ADP.". Biochem. Int.. 23(1): 151-156. (1991). (PMID: 1863268).
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  40. Guranowski, A.; Sillero, M.A.; Sillero, A. "Firefly luciferase synthesizes P1,P4-bis(5'-adenosyl)tetraphosphate (Ap4A) and other dinucleoside polyphosphates.". FEBS Lett.. 271(1-2): 215-218. (1990). (PMID: 2172002).
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  41. Ribeiro, J.M.; Ruiz, A.; Sillero, M.A.; Sillero, A. "Theoretical isoelectric points and electric charges of mutated human hemoglobin subunits.". Clin. Chim. Acta. 190(3): 189-197. (1990). (PMID: 2253399).
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  42. Meireles Ribeiro, J.; Ruiz, A.; Sillero, A.; Günther Sillero, M.A. "A low Km nucleoside 3'(2'),5-bisphosphate 3'(2')-phosphohydrolase from rat liver.". Biochimie. 72(4): 227-234. (1990). (PMID: 2166593).
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  43. Ruiz, A.; Hurtado, C.; Meireles Ribeiro, J.; Sillero, A.; Günther Sillero, M.A. "Hydrolysis of bis(5'-nucleosidyl) polyphosphates by Escherichia coli 5'-nucleotidase.". J. Bacteriol.. 171(12): 6703-6709. (1989). (PMID: 2556371).
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  44. García-Díaz, M.; Canales, J.; Sillero, M.A.; Sillero, A.; Cameselle, J.C. "Phosphoglycerate kinase from yeast synthesizes guanosine 5'-tetraphosphate.". Biochem. Int.. 19(6): 1253-1264. (1989). (PMID: 2635862).
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  45. Buitrago, F.; Canales, J.; Günther Sillero, M.A.; Sillero, A. "Occurrence of a novel nucleotide, Zpp5'A2'p, in rat liver extracts.". Biochem. Int.. 16(1): 175-184. (1988). (PMID: 3355573).
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  46. Canales, J.; Buitrago, F.; Sillero, M.A.; Sillero, A. "Rat liver contains a novel nucleotide, Ypp5'A2'p, related to adenosine 2',5'-bisphosphate.". Biochem. Int.. 15(2): 419-429. (1987). (PMID: 3435533).
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  47. Pinto, R.M.; Canales, J.; Faraldo, A.; Sillero, A.; Günther Sillero, M.A. "Cytosol 5'-nucleotidase from Artemia embryos. Purification and properties.". Comp. Biochem. Physiol., B. 86(1): 49-53. (1987). (PMID: 3030628).
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  48. Hurtado, C.; Ruíz, A.; Sillero, A.; Sillero, M.A. "Specific magnesium-dependent diadenosine 5',5'''-P1,P3-triphosphate pyrophosphohydrolase in Escherichia coli.". J. Bacteriol.. 169(4): 1718-1723. (1987). (PMID: 3031018).
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  49. Pinto, R.M.; Canales, J.; Günther Sillero, M.A.; Sillero, A. "Diadenosine tetraphosphate activates cytosol 5'-nucleotidase.". Biochem. Biophys. Res. Commun.. 138(1): 261-267. (1986). (PMID: 3017317).
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  50. Buitrago, F.; Canales, J.; Günther-Sillero, M.A.; Sillero, A. "Occurrence of adenosine 2',5'-bisphosphate in rat liver.". Biochim. Biophys. Acta. 881(2): 276-280. (1986). (PMID: 3955075).
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  51. Costas, M.J.; Cameselle, J.C.; Sillero, M.A.; Sillero, A. "Occurrence of dinucleosidetriphosphatase in the cytosol and particulate fractions from rat liver.". Int. J. Biochem.. 17(8): 903-909. (1985). (PMID: 2995162).
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  52. Fernández, A.; Canales, J.; Pinto, R.M.; Faraldo, A.; Sillero, M.A.; Sillero, A. "Adenosine deaminase isozymes in Artemia.". Comp. Biochem. Physiol., B. 78(2): 481-484. (1984). (PMID: 6467911).
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  53. Costas, M.J.; Montero, J.M.; Cameselle, J.C.; Sillero, M.A.; Sillero, A. "Dinucleosidetriphosphatase from rat brain.". Int. J. Biochem.. 16(7): 757-762. (1984). (PMID: 6088316).
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  54. Fernández, A.; Costas, M.J.; Sillero, M.A.; Sillero, A. "Diadenosine tetraphosphate activates AMP deaminase from rat muscle.". Biochem. Biophys. Res. Commun.. 121(1): 155-161. (1984). (PMID: 6732798).
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  55. Cameselle, J.C.; Costas, M.J.; Günther Sillero, M.A.; Sillero, A. "Two low Km hydrolytic activities on dinucleoside 5',5"'-P1,P4-tetraphosphates in rat liver. Characterization as the specific dinucleoside tetraphosphatase and a phosphodiesterase I-like enzyme.". J. Biol. Chem.. 259(5): 2879-2885. (1984). (PMID: 6321483).
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  56. Pinto, R.M.; Faraldo, A.; Fernández, A.; Canales, J.; Sillero, A.; Sillero, M.A. "Adenylosuccinate lyase from Artemia embryos. Purification and properties.". J. Biol. Chem.. 258(20): 12513-12519. (1983). (PMID: 6630197).
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  57. Costas, M.J.; Cameselle, J.C.; Günther Sillero, M.A.; Sillero, A. "Presence of cytidine 5'-tetraphosphate in commerical samples of cytidine 5'-triphosphate.". Anal. Biochem.. 134(2): 455-458. (1983). (PMID: 6650831).
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  58. Cameselle, J.C.; Costas, M.J.; Sillero, M.A.; Sillero, A. "Dinucleosidetetraphosphatase inhibition by Zn(II).". Biochem Biophys Res Commun. 113(2): 717-722. (1983). (PMID: 6307299).
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  59. Grau, V.P.; Sillero, M.A.; Sillero, A. "Binding of P1,P4-bis(5'-guanosyl)tetraphosphate to brain.". J. Biol. Chem.. 257(20): 11848-11851. (1982). (PMID: 7118913).
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  60. Moreno, A.; Lobatón, C.D.; Sillero, M.A.; Sillero, A. "Dinucleosidetetraphosphatase from Ehrlich ascites tumour cells: inhibition by adenosine, guanosine and uridine 5'-tetraphosphates.". Int. J. Biochem.. 14(7): 629-634. (1982). (PMID: 6286385).
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  61. Cameselle, J.C.; Costas, M.J.; Sillero, M.A.; Sillero, A. "Bis-(5'-guanosyl) tetraphosphatase in rat tissues.". Biochem. J.. 201(2): 405-410. (1982). (PMID: 6282267).
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  62. Vallejo, C.G.; Sillero, M.A.; Marco, R. "Mitochondrial maturation during Artemia salina embryogenesis. General description of the process.". Cell Mol Biol Incl Cyto Enzymol. 25(2): 113-124. (1979). (PMID: 575312).
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  63. Olalla, A.; Osuna, C.; Sebastian, J.; Sillero, A.; Sillero, M.A. "Purification and properties of three proteases from the larvae of the brine shrimp Artemia salina.". Biochim. Biophys. Acta. 523(1): 181-190. (1978). (PMID: 629986).
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  64. Osuna, C.; Olalla, A.; Sillero, A.; Günther Sillero, M.A.; Sebastián, J. "Induction of multiple proteases during the early larval development of Artemia salina.". Dev. Biol.. 61(1): 94-9103. (1977). (PMID: 924026).
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  65. Sillero, M.A.; Villalba, R.; Moreno, A.; Quintanilla, M.; Lobatón, C.D.; Sillero, A. "Dinucleosidetriphosphatase from rat liver. Purification and properties.". Eur. J. Biochem.. 76(2): 331-337. (1977). (PMID: 196848).
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  66. Renart, M.F.; Renart, J.; Sillero, M.A.; Sillero, A. "Guanosine monophosphate reductase from Artemia salina: Inhibition by xanthosine monophosphate and activation by diguanosine tetraphosphate.". Biochemistry. 15(23): 4962-4966. (1976). (PMID: 990256).
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  67. Vallejo, C.G.; Lobaton, C.D.; Quintanilla, M.; Sillero, A.; Sillero, M.A. "Dinucleosidasetetraphosphatase in rat liver and Artemia salina.". Biochim. Biophys. Acta. 438(1): 304-309. (1976). (PMID: 181087).
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  68. Lobatón, C.D.; Sillero, M.A.; Sillero, A. "Diadenosine triphosphate splitting by rat liver extracts.". Biochem. Biophys. Res. Commun.. 67(1): 279-286. (1975). (PMID: 173305).
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  69. Moreno, A.; Vallejo, C.G.; Sillero, A.; Sillero, M.A. "Wide occurrence of guanosine 5'-tetraphosphate in commercial preparations of GTP.". Anal. Biochem.. 68(2): 648-650. (1975). (PMID: 173207).
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  70. Lobatón, C.D.; Vallejo, C.G.; Sillero, A.; Sillero, M.A. "Diguanosinetetraphosphatase from rat liver: Acitivity on diadenosine tetraphosphate and inhibition by adenosine tetraphosphate.". Eur. J. Biochem.. 50(3): 495-501. (1975). (PMID: 163189).
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  71. Vallejo, C.G.; Sillero, M.A.; Sillero, A. "Diguanosinetetraphosphate guanylohydrolase in Artemia salina.". Biochim. Biophys. Acta. 358(1): 117-125. (1974). (PMID: 4368591).
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  72. Lee-Huang, S.; Sillero, M.A.; Ochoa, S. "Isolation and properties of crystalline initiation factor F1 from Escherichia coli ribosomes.". Eur J Biochem. 18(4): 536-543. (1971). (PMID: 5545011).
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  73. Sillero, A.; Sillero, M.A.; Sols, A. "Development of the enzymes of fructose and glyceraldehyde metabolism in liver.". Enzymol Biol Clin (Basel). 11(6): 563-566. (1970). (PMID: 5312927).
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  74. Sabol, S.; Sillero, M.A.; Iwasaki, K.; Ochoa, S. "Purification and properties of initiation factor F3.". Nature. 228(5278): 1269-1273. (1970). (PMID: 4922687).
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  75. Wahba, A.J.; Chae, Y.B.; Iwasaki, K.; Mazumder, R.; Miller, M.J.; Sabol, S.; Sillero, M.A. "Initiation of protein synthesis in Escherichia coli. I. Purification and properties of the initiation factors.". Cold Spring Harb. Symp. Quant. Biol.. 34(): 285-290. (1969). (PMID: 4909505).
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  76. Wahba, A.J.; Iwasaki, K.; Miller, M.J.; Sabol, S.; Sillero, M.A.; Vasquez, C. "Initiation of protein synthesis in Escherichia coli. II. Role of the initiation factors in polypeptide synthesis.". Cold Spring Harb. Symp. Quant. Biol.. 34(): 291-299. (1969). (PMID: 4909506).
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  77. Sillero, M.A.; Sillero, A.; Sols, A. "Enzymes involved in fructose metabolism in lir and the glyceraldehyde metabolic crossroads.". Eur. J. Biochem.. 10(2): 345-350. (1969). (PMID: 5823111).
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  78. Sillero, A.; Sillero, M.A.; Sols, A. "Regulation of the level of key enzymes of glycolysis and gluconeogenesis in liver.". Eur. J. Biochem.. 10(2): 351-354. (1969). (PMID: 4309869).
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  79. Günther, M.A.; Sillero, A.; Sols, A. "Fructokinase assay with a specific spectrophotometric method using 1-phosphofructokinase.". Enzymol Biol Clin (Basel). 8(5): 341-352. (1967). (PMID: 4228981).
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  80. Günther, M.A.; López-Quijada, C.; Candela, J.L. "Efect of "Dicumarol" (bishydroxycoumarin) on insulin secretion in vitro.". Life Sci.. 5(12): 1091-1095. (1966). (PMID: 4164320).
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