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spacerTrabajos Publicados en gpzaioyvocg por Alain Juan de Solis
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  1. De Solis, A.J.; Del Río-Martín, A.; Radermacher, J.; Chen, W.; Steuernagel, L.; Bauder, C.A.; Eggersmann, F.R.; Morgan, D.A.; Cremer, A.L.; Sué, M.; Germer, M.; Kukat, C.; Vollmar, S.; Backes, H.; Rahmouni, K.; Kloppenburg, P.; Brüning, J.C. "Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism.". Nat Metab. 6(3): 473-493. (2024). (PMID: 38378998).
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  2. Engström Ruud, L.; Pereira, M.M.A.; de Solis, A.J.; Fenselau, H.; Brüning, J.C. "NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons.". Nat Commun. 11(1): 442. (2020). (PMID: 31974377).
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  3. Wang, L.; De Solis, A.J.; Goffer, Y.; Birkenbach, K.E.; Engle, S.E.; Tanis, R.; Levenson, J.M.; Li, X.; Rausch, R.; Purohit, M.; Lee, J.Y.; Tan, J.; De Rosa, M.C.; Doege, C.A.; Aaron, H.L.; Martins, G.J.; Brüning, J.C.; Egli, D.; Costa, R.; Berbari, N.; Leibel, R.L.; Stratigopoulos, G. "Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development.". JCI Insight. 4(3): . (2019). (PMID: 30728336).
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  4. Juan De Solis, A.; Baquero, A.F.; Bennett, C.M.; Grove, K.L.; Zeltser, L.M. "Postnatal undernutrition delays a key step in the maturation of hypothalamic feeding circuits.". Mol Metab. 5(3): 198-209. (2016). (PMID: 26977392).
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    METHODS
    We used the large litter (LL) size model to study the impacts of postnatal UN followed by catch-up growth. We evaluated the maturation of presynaptic and postsynaptic inhibitory systems in NAG neurons using a combination of electrophysiological and molecular criteria, in conjunction with leptin's ability to suppress fasting-induced hyperphagia.

    RESULTS
    The onset of KATP channel subunit expression and function, the switch in leptin's effect on NAG neurons, the ingrowth of inhibitory inputs to NAG neurons, and the development of homeostatic feedback to feeding circuits were delayed in LL offspring relative to controls. The development of functional KATP channels and the establishment of leptin-mediated suppression of food intake in the peri-weaning period were tightly linked and were not initiated until growth and adiposity of LL offspring caught up to controls.

    CONCLUSIONS
    Our data support the idea that initiation of KATP channel subunit expression in NAG neurons serves as a molecular gatekeeper for the maturation of homeostatic feeding circuits.

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  5. Baquero, A.F.; de Solis, A.J.; Lindsley, S.R.; Kirigiti, M.A.; Smith, M.S.; Cowley, M.A.; Zeltser, L.M.; Grove, K.L. "Developmental switch of leptin signaling in arcuate nucleus neurons.". J Neurosci. 34(30): 9982-9994. (2014). (PMID: 25057200).
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  6. Neria, F.; Caramelo, C.; Peinado, H.; González-Pacheco, F.R.; Deudero, J.J.; de Solis, A.J.; Fernández-Sánchez, R.; Peñate, S.; Cano, A.; Castilla, M.A. "Mechanisms of endothelial cell protection by blockade of the JAK2 pathway.". Am. J. Physiol., Cell Physiol.. 292(3): C1123-31. (2007). (PMID: 17035297).
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Instituto de Investigaciones Biomédicas "Alberto Sols"
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