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PUBLICACIONES

 

 

spacerTrabajos Publicados en gpzaioyvocg por Susana Alemany de la Peña
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  1. Notario, L.; Guerrero-Espinosa, E.; Nistal, M.; Lauzurica, P.; Aranda, A.; Alemany, S. "Thyroid hormone deficiency worsens outcomes in vaccinia virus infection.". J Virol. (): e0129425. (2025). (PMID: 41263555).
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  2. Vladimir de la Rosa, J.; Tabraue, C.; Huang, Z.; Orizaola, M.C.; Martin-Rodríguez, P.; Steffensen, K.R.; Zapata, J.M.; Boscá, L.; Tontonoz, P.; Alemany, S.; Treuter, E.; Castrillo, A. "Reprogramming of the LXRα Transcriptome Sustains Macrophage Secondary Inflammatory Responses.". Adv Sci (Weinh). (): e2307201. (2024). (PMID: 38549193).
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  3. Contreras-Jurado, C.; Montero-Pedrazuela, A.; Pérez, R.F.; Alemany, S.; Fraga, M.F.; Aranda, A. "The thyroid hormone enhances mouse embryonic fibroblasts reprogramming to pluripotent stem cells: role of the nuclear receptor corepressor 1.". Front Endocrinol (Lausanne). 14(): 1235614. (2023). (PMID: 38107517).
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  4. Gutierrez, A.H.; Mazariegos, M.S.; Alemany, S.; Nevzorova, Y.A.; Cubero, F.J.; Sanz-García, C. "Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease.". Biochim Biophys Acta Mol Basis Dis. 1869(4): 166660. (2023). (PMID: 36764206).
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  5. Amich, I.; Anguita, E.; Escribano-Serrat, S.; Alvarez, C.; Rodríguez-Muñoz, D.; García, V.; Bello, R.; Peña-Pedrosa, J.A.; Martínez-Micaelo, N.; Amigó, N.; Ortiz, P.; Torrejón, M.J.; Boscá, L.; Martín-Sánchez, J.; Aranda, A.; Alemany, S. "Free triiodothyronine levels and age influences the metabolic profile and COVID-19 severity parameters in euthyroid and levothyroxine-treated patients.". Front Endocrinol (Lausanne). 13(): 1025032. (2022). (PMID: 36440226).
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  6. López-Mateo, I.; Rodríguez-Muñoz, D.; de La Rosa, J.V.; Castrillo, A.; Alemany, S.; Aranda, A. "Regulation of metabolic and transcriptional responses by the thyroid hormone in cellular models of murine macrophages.". Front Immunol. 13(): 923727. (2022). (PMID: 35935955).
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  7. Rodriguez-Muñoz, D.; Sánchez, Á.; Pérez-Benavente, S.; Contreras-Jurado, C.; Montero-Pedrazuela, A.; Toledo-Castillo, M.; Gutiérrez-Hernández, M.; Rodrigues-Díez, R.; Folgueira, C.; Briones, A.M.; Sabio, G.; Monedero-Cobeta, I.; Chávez-Coira, I.; Castejón, D.; Fernández-Valle, E.; Regadera, J.; Bautista, J.M.; Aranda, A.; Alemany, S. "Hypothyroidism confers tolerance to cerebral malaria.". Sci Adv. 8(14): eabj7110. (2022). (PMID: 35385300).
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  8. Sánchez, Á.; Orizaola, M.C.; Rodríguez-Muñoz, D.; Aranda, A.; Castrillo, A.; Alemany, S. "Stress erythropoiesis in atherogenic mice.". Sci Rep. 10(1): 18469. (2020). (PMID: 33116141).
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  9. Sánchez, Á.; Anguita, E.; Chaparro, A.; Roldán-Etcheverry, J.J.; López-García, A.; Ramos-Acosta, C.; Oancea, R.; Rodriguez-Muñoz, D.; Alemany, S. "Abnormal Dendritic Cell-poiesis in Patients With Lower-risk Myelodysplastic Syndromes.". Hemasphere. 4(1): e335. (2020). (PMID: 32072149).
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  10. Sánchez, Á.; Contreras-Jurado, C.; Rodríguez, D.; Regadera, J.; Alemany, S.; Aranda, A. "Hematopoiesis in aged female mice devoid of thyroid hormone receptors.". J. Endocrinol.. 244(1): 83-94. (2020). (PMID: 31585438).
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  11. López-Mateo, I.; Alonso-Merino, E.; Suárez-Cabrera, C.; Park, J.W.; Cheng, S.Y.; Alemany, S.; Paramio, J.M.; Aranda, A. "The thyroid hormone receptor β inhibits self-renewal capacity of breast cancer stem cells.". Thyroid. (): . (2019). (PMID: 31760908).
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  12. Ramón-Vázquez, A.; de la Rosa, J.V.; Tabraue, C.; Lopez, F.; Díaz-Chico, B.N.; Bosca, L.; Tontonoz, P.; Alemany, S.; Castrillo, A. "Common and Differential Transcriptional Actions of Nuclear Receptors LXRα and LXRβ in macrophages.". Mol. Cell. Biol.. (): . (2019). (PMID: 30602495).
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  13. Sánchez, Á.; Mengíbar, M.; Fernández, M.; Alemany, S.; Heras, A.; Acosta, N. "Influence of Preparation Methods of Chitooligosaccharides on Their Physicochemical Properties and Their Anti-Inflammatory Effects in Mice and in RAW264.7 Macrophages.". Mar Drugs. 16(11): . (2018). (PMID: 30400250).
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  14. Alsina-Beauchamp, D.; Escós, A.; Fajardo, P.; González-Romero, D.; Díaz-Mora, E.; Risco, A.; Martín-Serrano, M.A.; Del Fresno, C.; Dominguez-Andrés, J.; Aparicio, N.; Zur, R.; Shpiro, N.; Brown, G.D.; Ardavín, C.; Netea, M.G.; Alemany, S.; Sanz-Ezquerro, J.J.; Cuenda, A. "Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity.". EMBO Mol Med. 10(5): . (2018). (PMID: 29661910).
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  15. Rada, P.; Pardo, V.; Mobasher, M.; Garcia, I.; Ruiz, L.; Gonzalez Rodriguez, A.; Sánchez Ramos, C.; Muntané, J.; Alemany, S.; James, L.P.; Simpson, K.J.; Monsalve, M.; Valdecantos, M.P.; Valverde, A. "SIRT1 CONTROLS ACETAMINOPHEN HEPATOTOXICITY BY MODULATING INFLAMMATION AND OXIDATIVE STRESS.". Antioxid. Redox Signal.. (): . (2017). (PMID: 29084443).
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  16. Sánchez, Á.; Relaño, C.; Carrasco, A.; Contreras-Jurado, C.; Martín-Duce, A.; Aranda, A.; Alemany, S. "Map3k8 controls granulocyte colony-stimulating factor production and neutrophil precursor proliferation in lipopolysaccharide-induced emergency granulopoiesis.". Sci Rep. 7(1): 5010. (2017). (PMID: 28694430).
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  17. Sanz-Garcia, C.; Sánchez, Á.; Contreras-Jurado, C.; Cales, C.; Barranquero, C.; Muñoz, M.; Merino, R.; Escudero, P.; Sanz, M.J.; Osada, J.; Aranda, A.; Alemany, S. "Map3k8 Modulates Monocyte State and Atherogenesis in ApoE-/- Mice.". Arterioscler. Thromb. Vasc. Biol.. 37(2): 237-246. (2017). (PMID: 27856455).
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  18. Contreras-Jurado, C.; Alonso-Merino, E.; Saiz-Ladera, C.; Valiño, A.J.; Regadera, J.; Alemany, S.; Aranda, A. "The Thyroid Hormone Receptors Inhibit Hepatic Interleukin-6 Signaling During Endotoxemia.". Sci Rep. 6(): 30990. (2016). (PMID: 27484112).
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  19. Boscá, L.; González-Ramos, S.; Prieto, P.; Fernández-Velasco, M.; Mojena, M.; Martín-Sanz, P.; Alemany, S. "Metabolic signatures linked to macrophage polarization: from glucose metabolism to oxidative phosphorylation.". Biochem. Soc. Trans.. 43(4): 740-744. (2015). (PMID: 26551722).
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  20. Berthou, F.; Ceppo, F.; Dumas, K.; Massa, F.; Vergoni, B.; Alemany, S.; Cormont, M.; Tanti, J.F. "The Tpl2 Kinase Regulates the COX-2/Prostaglandin E2 Axis in Adipocytes in Inflammatory Conditions.". Mol. Endocrinol.. 29(7): 1025-1036. (2015). (PMID: 26020725).
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  21. Sanz-Garcia, C.; Nagy, L.E.; Lasunción, M.A.; Fernandez, M.; Alemany, S. "Cot/tpl2 participates in the activation of macrophages by adiponectin.". J. Leukoc. Biol.. 95(6): 917-930. (2014). (PMID: 24532642).
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  22. Sanz-Garcia, C.; Ferrer-Mayorga, G.; González-Rodríguez, Á.; Valverde, A.M.; Martín-Duce, A.; Velasco-Martín, J.P.; Regadera, J.; Fernández, M.; Alemany, S. "Sterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2.". J. Biol. Chem.. 288(21): 15342-15351. (2013). (PMID: 23572518).
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  23. López-Pelaéz, M.; Fumagalli, S.; Sanz, C.; Herrero, C.; Guerra, S.; Fernandez, M.; Alemany, S. "Cot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like receptor-activated macrophages.". Mol. Biol. Cell. 23(15): 2982-2992. (2012). (PMID: 22675026).
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  24. Fernández, M.; Manso, R.; Bernaldo de Quirós, F.; Bernáldez, F.; López, P.; Martín-Duce, A.; Alemany, S. "Involvement of Cot activity in the proliferation of ALCL lymphoma cells.". Biochem. Biophys. Res. Commun.. 411(4): 655-660. (2011). (PMID: 21741362).
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  25. López-Peláez, M.; Soria-Castro, I.; Boscá, L.; Fernández, M.; Alemany, S. "Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression.". Eur. J. Immunol.. 41(6): 1733-1741. (2011). (PMID: 21469113).
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  26. Soria-Castro, I.; Krzyzanowska, A.; Pelaéz, M.L.; Regadera, J.; Ferrer, G.; Montoliu, L.; Rodríguez-Ramos, R.; Fernández, M.; Alemany, S. "Cot/tpl2 (MAP3K8) mediates myeloperoxidase activity and hypernociception following peripheral inflammation.". J. Biol. Chem.. 285(44): 33805-33815. (2010). (PMID: 20736176).
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  27. Rodríguez, C.; López, P.; Pozo, M.; Duce, A.M.; López-Pelaéz, M.; Fernández, M.; Alemany, S. "COX2 expression and Erk1/Erk2 activity mediate Cot-induced cell migration.". Cell. Signal.. 20(9): 1625-1631. (2008). (PMID: 18572386).
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  28. Rodríguez, C.; Pozo, M.; Nieto, E.; Fernández, M.; Alemany, S. "TRAF6 and Src kinase activity regulates Cot activation by IL-1.". Cell. Signal.. 18(9): 1376-1385. (2006). (PMID: 16371247).
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  29. Pérez de Diego, R.; López-Granados, E.; Pozo, M.; Rodríguez, C.; Sabina, P.; Ferreira, A.; Fontan, G.; García-Rodríguez, M.C.; Alemany, S. "Bruton's tyrosine kinase is not essential for LPS-induced activation of human monocytes.". J. Allergy Clin. Immunol.. 117(6): 1462-1469. (2006). (PMID: 16751014).
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  30. Caivano, M.; Rodriguez, C.; Cohen, P.; Alemany, S. "15-Deoxy-Delta12,14-prostaglandin J2 regulates endogenous Cot MAPK kinase kinase 1 activity induced by lipopolysaccharide.". J. Biol. Chem.. 278(52): 52124-52130. (2003). (PMID: 14557273).
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  31. Gándara, M.L.; López, P.; Hernando, R.; Castaño, J.G.; Alemany, S. "The COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activity.". Mol. Cell. Biol.. 23(20): 7377-7390. (2003). (PMID: 14517305).
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  32. de Gregorio, R.; Iñiguez, M.A.; Fresno, M.; Alemany, S. "Cot kinase induces cyclooxygenase-2 expression in T cells through activation of the nuclear factor of activated T cells.". J. Biol. Chem.. 276(29): 27003-27009. (2001). (PMID: 11356833).
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  33. Velasco-Sampayo, A.; Alemany, S. "p27kip protein levels and E2F activity are targets of Cot kinase during G1 phase progression in T cells.". J. Immunol.. 166(10): 6084-6090. (2001). (PMID: 11342626).
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  34. Sánchez-Góngora, E.; Lisbona, C.; de Gregorio, R.; Ballester, A.; Calvo, V.; Pérez-Jurado, L.; Alemany, S. "COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activation.". J. Biol. Chem.. 275(40): 31379-31386. (2000). (PMID: 10896655).
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  35. Campos, C.; de Gregorio, R.; García-Nieto, R.; Gago, F.; Ortiz, P.; Alemany, S. "Regulation of cyclooxygenase activity by metamizol.". Eur. J. Pharmacol.. 378(3): 339-347. (1999). (PMID: 10493111).
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  36. Ballester, A.; Velasco, A.; Tobeña, R.; Alemany, S. "Cot kinase activates tumor necrosis factor-alpha gene expression in a cyclosporin A-resistant manner.". J. Biol. Chem.. 273(23): 14099-14106. (1998). (PMID: 9603908).
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  37. Lisbona, C.; Alemany, S.; Fernández-Renart, M. "Regulation of ERK2 dephosphorylation in G1-stimulated rat T lymphoblasts.". J. Clin. Immunol.. 17(6): 494-501. (1997). (PMID: 9418190).
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  38. Ballester, A.; Tobeña, R.; Lisbona, C.; Calvo, V.; Alemany, S. "Cot kinase regulation of IL-2 production in Jurkat T cells.". J. Immunol.. 159(4): 1613-1618. (1997). (PMID: 9257820).
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  39. Tobeña, R.; Horikawa, S.; Calvo, V.; Alemany, S. "Interleukin-2 induces gamma-S-adenosyl-L-methionine synthetase gene expression during T-lymphocyte activation.". Biochem. J.. 319 ( Pt 3)(): 929-933. (1996). (PMID: 8921001).
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  40. Carrera, A.C.; Calvo, V.; Borlado, L.R.; Paradis, H.; Alemany, S.; Roberts, T.M.; Martinez-A, C. "The catalytic domain of pp56(lck), but not its regulatory domain, is sufficient for inducing IL-2 production.". J. Immunol.. 157(9): 3775-3782. (1996). (PMID: 8892605).
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  41. Lisbona, C.; Alemany, S.; Calvo, V.; Fernandez-Renart, M. "Raf-1 and ERK2 kinases are required for phorbol 12,13-dibutyrate-stimulated proliferation of rat lymphoblasts. ERK2 activation precedes Raf-1 hyperphosphorylation.". Eur. J. Immunol.. 24(11): 2746-2754. (1994). (PMID: 7957567).
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  42. Garcia, I.; Pipaon, C.; Alemany, S.; Perez-Castillo, A. "Induction of NGFI-B gene expression during T cell activation. Role of protein phosphatases.". J Immunol. 153(8): 3417-3425. (1994). (PMID: 7930567).
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  43. Perez-Castillo, A.; Pipaón, C.; García, I.; Alemany, S. "NGFI-A gene expression is necessary for T lymphocyte proliferation.". J. Biol. Chem.. 268(26): 19445-19450. (1993). (PMID: 8366092).
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  44. Garcia, I.; Perez-Castillo, A.; Moreno, J.; Alemany, S. "Beta-endorphin inhibits interleukin-2 release and expression of interleukin-2 receptors in concanavalin A-stimulated splenic lymphocytes.". Lymphokine Cytokine Res.. 11(6): 339-345. (1992). (PMID: 1477186).
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  45. Puerta, J.; Mato, J.M.; Alemany, S. "Phospho-oligosaccharide dependent phosphorylation of ATP citrate lyase.". Adv. Enzyme Regul.. 30(): 109-117. (1990). (PMID: 2119547).
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  46. Strålfors, P.; Alemany, S. "Phosphorylation control by insulin in adipocytes is interfered with at a post-receptor step by phosphoinositol and glucosamine.". FEBS Lett.. 268(1): 169-172. (1990). (PMID: 1696549).
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  47. Alemany, S.; Puerta, J.; Guadaño, A.; Mato, J.M. "Modulation of casein kinase II activity by the polar head group of an insulin-sensitive glycosyl-phosphatidylinositol.". J. Biol. Chem.. 265(9): 4849-4852. (1990). (PMID: 2138621).
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  48. Cabrero, C.; Duce, A.M.; Ortiz, P.; Alemany, S.; Mato, J.M. "Specific loss of the high-molecular-weight form of S-adenosyl-L-methionine synthetase in human liver cirrhosis.". Hepatology. 8(6): 1530-1534. (1988). (PMID: 3192166).
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  49. Cohen, P.; Alemany, S.; Hemmings, B.A.; Resink, T.J.; Strålfors, P.; Tung, H.Y. "Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle.". Meth. Enzymol.. 159(): 390-408. (1988). (PMID: 2842604).
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  50. Cabrero, C.; Alemany, S. "Conversion of rat liver S-adenosyl-L-methionine synthetase from high-Mr form to low-Mr form by LiBr.". Biochim. Biophys. Acta. 952(3): 277-281. (1988). (PMID: 2827780).
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  51. Alemany, S.; Mato, J.M.; Strålfors, P. "Phospho-dephospho-control by insulin is mimicked by a phospho-oligosaccharide in adipocytes.". Nature. 330(6143): 77-79. (1987). (PMID: 3313056).
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  52. Cabrero, C.; Puerta, J.; Alemany, S. "Purification and comparison of two forms of S-adenosyl-L-methionine synthetase from rat liver.". Eur. J. Biochem.. 170(1-2): 299-304. (1987). (PMID: 3121322).
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  53. da Cruz e Silva, O.B.; Alemany, S.; Campbell, D.G.; Cohen, P.T. "Isolation and sequence analysis of a cDNA clone encoding the entire catalytic subunit of a type-2A protein phosphatase.". FEBS Lett. 221(2): 415-422. (1987). (PMID: 3040474).
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  54. Alemany, S.; Pelech, S.; Brierley, C.H.; Cohen, P. "The protein phosphatases involved in cellular regulation. Evidence that dephosphorylation of glycogen phosphorylase and glycogen synthase in the glycogen and microsomal fractions of rat liver are catalysed by the same enzyme: protein phosphatase-1.". Eur. J. Biochem.. 156(1): 101-110. (1986). (PMID: 3007140).
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  55. Alemany, S.; Cohen, P. "Phosphorylase a is an allosteric inhibitor of the glycogen and microsomal forms of rat hepatic protein phosphatase-1.". FEBS Lett.. 198(2): 194-202. (1986). (PMID: 3007211).
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  56. Tung, H.Y.; Alemany, S.; Cohen, P. "The protein phosphatases involved in cellular regulation. 2. Purification, subunit structure and properties of protein phosphatases-2A0, 2A1, and 2A2 from rabbit skeletal muscle.". Eur. J. Biochem.. 148(2): 253-263. (1985). (PMID: 2985385).
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  57. Alemany, S.; Tung, H.Y.; Shenolikar, S.; Pilkis, S.J.; Cohen, P. "The protein phosphatases involved in cellular regulation. Antibody to protein phosphatase-2A as a probe of phosphatase structure and function.". Eur J Biochem. 145(1): 51-56. (1984). (PMID: 6092082).
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  58. Pajares, M.A.; Alemany, S.; Varela, I.; Marin Cao, D.; Mato, J.M. "Purification and photoaffinity labelling of lipid methyltransferase from rat liver.". Biochem. J.. 223(1): 61-66. (1984). (PMID: 6497846).
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  59. Gil, M.G.; van Lookeren Campagne, M.W.; Alemany, S.; Municio, A.M.; Mato, J.M. "Effect of fatty acid anilides on the generation of arachidonic acid by human polymorphonuclear leukocytes.". FEBS Lett. 162(1): 151-155. (1983). (PMID: 6413256).
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  60. Mato, J.M.; Alvarez Chiva, V.; Marín Cao, D.; Varela, I.; García Gil, M.; Alemany, S. "[Hormonal regulation of the synthesis of phosphatidylcholine by transmethylation].". Rev Clin Esp. 171(1): 7-10. (1983). (PMID: 6658087).
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  61. Mato, J.M.; Alemany, S. "What is the function of phospholipid N-methylation?". Biochem J. 213(1): 1-10. (1983). (PMID: 6311156).
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  62. Alemany, S.; Varela, I.; Mato, J.M. "Inhibition of phosphatidylcholine synthesis by vasopressin and angiotensin in rat hepatocytes.". Biochem J. 208(2): 453-457. (1982). (PMID: 6818955).
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  63. Alemany, S.; Varela, I.; Harper, J.F.; Mato, J.M. "Calmodulin regulation of phospholipid and fatty acid methylation by rat liver microsomes.". J Biol Chem. 257(16): 9249-9251. (1982). (PMID: 6809733).
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  64. Alemany, S.; Varela, I.; Mato, J.M. "Stimulation by vasopressin and angiotensin of phospholipid methyltransferase in isolated rat hepatocytes.". FEBS Lett. 135(1): 111-114. (1981). (PMID: 6797839).
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  65. Alemany, S.; García Gil, M.; Mato, J.M. "Regulation by guanosine 3':5'-cyclic monophosphate of phospholipid methylation during chemotaxis in Dictyostelium discoideum.". Proc Natl Acad Sci U S A. 77(12): 6996-6999. (1980). (PMID: 6261233).
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  66. Castaño, J.G.; Alemany, S.; Nieto, A.; Mato, J.M. "Activation of phospholipid methyltransferase by glucagon in rat hepatocytes.". J Biol Chem. 255(19): 9041-9043. (1980). (PMID: 6251072).
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  67. Gil, M.G.; Alemany, S.; Cao, D.M.; Castano, J.G.; Mato, J.M. "Calmodulin modulates phospholipid methylation in Dictyostelium discoideum.". Biochem Biophys Res Commun. 94(4): 1325-1330. (1980). (PMID: 6772186).
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