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PUBLICACIONES

 

 

spacerTrabajos Publicados por Carmen Valenzuela Miranda
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  1. Socuéllamos, P.G.; Ruiz-Robles, J.M.; Cruz, F.M.; Macías, Á.; Vera-Zambrano, A.; Moreno-Manuel, A.I.; Prior, C.; Cartón, A.J.; Valenzuela, C.; Jalife, J. "MOG1L18F-mediated increase in late sodium current produces Long QT Syndrome.". medRxiv. (): . (2025). (PMID: 41445668).
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  2. Baena-Nuevo, M.; Vera-Zambrano, A.; Martinez-Laperche, C.; Buño, I.; Muñoz-Calleja, C.; Valenzuela, C.; Zapata, J.M.; Perez-Chacon, G. "Indole-3-carbinol is an inhibitor of KV1.3 potassium voltage-gated channel activity in chronic lymphocytic leukemia cells.". Eur J Pharmacol. (): 178281. (2025). (PMID: 41138834).
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  3. Cruz, A.; Ronchi, C.; Bartolucci, C.; Socuéllamos, P.G.; Benito-Bueno, A.; Severi, S.; Zaza, A.; Valenzuela, C. "RvD1 and LXA4 inhibitory effects on cardiac voltage-gated potassium channels.". Biomed Pharmacother. 187(): 118083. (2025). (PMID: 40273690).
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  4. Cruz, F.M.; Moreno-Manuel, A.I.; Pérez, P.S.; Ruiz-Robles, J.M.; Socuellamos, P.G.; Gutiérrez, L.K.; Vera-Pedrosa, M.L.; Gutierrez, A.T.; Mondéjar Parreño, G.; Macías, Á.; Martínez-Carrascoso, I.; Bermúdez-Jiménez, F.J.; Arias Santiago, S.; Martínez de Benito, F.; Braza-Boils, A.; Valenzuela, C.; Morillo, C.A.; Zorio, E.; Jiménez-Jaimez, J.; Jalife, J. "Kir2.1 mutations differentially increase the risk of flecainide proarrhythmia in Andersen Tawil Syndrome.". medRxiv. (): . (2024). (PMID: 39711719).
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  5. Sastre, D.; Colomer-Molera, M.; Roig, S.R.; de Benito-Bueno, A.; Socuellamos, P.G.; Fernandez-Ballester, G.; Valenzuela, C.; Felipe, A. "Molecular mapping of KCNE4-dependent regulation of Kv1.3.". Am J Physiol Cell Physiol. (): . (2024). (PMID: 39466181).
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  6. Sastre, D.; Colomer-Molera, M.; de Benito-Bueno, A.; Valenzuela, C.; Fernández-Ballester, G.; Felipe, A. "KCNE4-dependent modulation of Kv1.3 pharmacology.". Biochem Pharmacol. (): 116368. (2024). (PMID: 38880360).
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  7. Serrano-Novillo, C.; Estadella, I.; Navarro-Pérez, M.; Oliveras, A.; de Benito-Bueno, A.; Socuéllamos, P.G.; Bosch, M.; Coronado, M.J.; Sastre, D.; Valenzuela, C.; Soeller, C.; Felipe, A. "Routing of Kv7.1 to endoplasmic reticulum plasma membrane junctions.". Acta Physiol (Oxf). (): e14106. (2024). (PMID: 38282556).
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  8. Peraza, D.A.; Povo-Retana, A.; Mojena, M.; García-Redondo, A.B.; Avilés, P.; Boscá, L.; Valenzuela, C. "Trabectedin modulates macrophage polarization in the tumor-microenvironment. Role of KV1.3 and KV1.5 channels.". Biomed Pharmacother. 161(): 114548. (2023). (PMID: 36940615).
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  9. Paz-García, M.; Povo-Retana, A.; Jaén, R.I.; Prieto, P.; Peraza, D.A.; Zaragoza, C.; Hernandez-Jimenez, M.; Pineiro, D.; Regadera, J.; García-Bermejo, M.L.; Rodríguez-Serrano, E.M.; Sánchez-García, S.; Moro, M.A.; Lizasoaín, I.; Delgado, C.; Valenzuela, C.; Boscá, L. "Beneficial effect of TLR4 blockade by a specific aptamer antagonist after acute myocardial infarction.". Biomed Pharmacother. 158(): 114214. (2023). (PMID: 36916435).
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  10. Socuéllamos, P.G.; de Benito-Bueno, A.; Ropero, M.; Diez, S.; Elizalde, P.; Bonache, M.A.; Viedma, C.; Martín-Martínez, M.; Gutiérrez-Rodríguez, M.; Valenzuela, C. "IQM-22110, a new selective inhibitor of KChIP3 and its electrophysiological effects on Kv4.3, Kv4.3/KChIP3 and Kv4.3/KChIP2 currents.". Biophys J. 122(3S1): 255a. (2023). (PMID: 36783256).
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  11. Vera-Zambrano, A.; Baena-Nuevo, M.; Rinné, S.; Villegas-Esguevillas, M.; Barreira, B.; Telli, G.; de Benito-Bueno, A.; Blázquez, J.A.; Climent, B.; Pérez-Vizcaino, F.; Valenzuela, C.; Decher, N.; Gonzalez, T.; Cogolludo, A. "Sigma-1 receptor modulation fine-tunes KV1.5 channels and impacts pulmonary vascular function.". Pharmacol Res. (): 106684. (2023). (PMID: 36740150).
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  12. Díaz Del Campo, L.S.; García-Redondo, A.B.; Rodriguez, C.; Zaragoza, C.; Duro-Sánchez, S.; Palmas, F.; de Benito-Bueno, A.; Socuéllamos, P.G.; Peraza, D.A.; Rodrigues-Diez, R.; Valenzuela, C.; Dalli, J.; Salaices, M.; Briones, A.M. "Resolvin D2 Attenuates Cardiovascular Damage in Angiotensin Ii-Induced Hypertension.". Hypertension. (): . (2022). (PMID: 36337053).
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  13. Galán-Vidal, J.; Socuéllamos, P.G.; Baena-Nuevo, M.; Contreras, L.; González, T.; Pérez-Poyato, M.S.; Valenzuela, C.; González-Lamuño, D.; Gandarillas, A. "A novel loss-of-function mutation of the voltage-gated potassium channel Kv10.2 involved in epilepsy and autism.". Orphanet J Rare Dis. 17(1): 345. (2022). (PMID: 36068614).
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  14. de Benito-Bueno, A.; Socuellamos, P.G.; Merinero, Y.G.; Cercos, P.; Izquierdo, C.; Daniel-Mozo, M.; Marín-Olivero, I.; Perez-Lara, A.; Gonzalez-Vera, J.A.; Orte, A.; Albert, A.; Martin-Martinez, M.; Gutierrez-Rodriguez, M.; Valenzuela, C. "Modulation of KV4.3-KChIP2 Channels by IQM-266: Role of DPP6 and KCNE2.". Int J Mol Sci. 23(16): . (2022). (PMID: 36012438).
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  15. Socuéllamos, P.G.; Olivos-Oré, L.A.; Barahona, M.V.; Cercós, P.; Pérez Pascual, M.; Arribas-Blázquez, M.; Naranjo, J.R.; Valenzuela, C.; Gutiérrez-Rodríguez, M.; Artalejo, A.R. "IQM-PC332, a Novel DREAM Ligand with Antinociceptive Effect on Peripheral Nerve Injury-Induced Pain.". Int J Mol Sci. 23(4): . (2022). (PMID: 35216258).
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  16. Povo-Retana, A.; Mojena, M.; Boscá, A.; Pedrós, J.; Peraza, D.A.; Valenzuela, C.; Laparra, J.M.; Calle, F.; Boscá, L. "Graphene Particles Interfere with Pro-Inflammatory Polarization of Human Macrophages: Functional and Electrophysiological Evidence.". Adv Biol (Weinh). (): e2100882. (2021). (PMID: 34590442).
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  17. Kiper, A.K.; Bedoya, M.; Stalke, S.; Marzian, S.; Ramírez, D.; de la Cruz, A.; Peraza, D.A.; Vera-Zambrano, A.; Márquez Montesinos, J.C.E.; Arévalo Ramos, B.A.; Rinné, S.; Gonzalez, T.; Valenzuela, C.; Gonzalez, W.; Decher, N. "Identification of a critical binding site for local anesthetics in the side pockets of Kv1 channels.". Br J Pharmacol. (): . (2021). (PMID: 33817777).
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  18. Olivencia, M.A.; Martínez-Casales, M.; Peraza, D.A.; García-Redondo, A.B.; Mondéjar-Parreño, G.; Hernanz, R.; Salaices, M.; Cogolludo, A.; Pennington, M.W.; Valenzuela, C.; Briones, A.M. "KV 1.3 channels are novel determinants of macrophage-dependent endothelial dysfunction in a mouse model with angiotensin II-induced hypertension.". Br J Pharmacol. (): . (2021). (PMID: 33556997).
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  19. Macias, A.; de la Cruz, A.; Peraza, D.A.; Benito-Bueno, A.; Gonzalez, T.; Valenzuela, C. "KV1.5-KVβ1.3 Recycling Is PKC-Dependent.". Int J Mol Sci. 22(3): . (2021). (PMID: 33572906).
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  20. Cercós, P.; Peraza, D.A.; Benito-Bueno, A.; Socuéllamos, P.G.; Aziz-Nignan, A.; Arrechaga-Estévez, D.; Beato, E.; Peña-Acevedo, E.; Albert, A.; González-Vera, J.A.; Rodríguez, Y.; Martín-Martínez, M.; Valenzuela, C.; Gutiérrez-Rodríguez, M. "Pharmacological Approaches for the Modulation of the Potassium Channel KV4.x and KChIPs.". Int J Mol Sci. 22(3): . (2021). (PMID: 33572566).
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  21. Oliveras, A.; Serrano-Novillo, C.; Moreno, C.; de la Cruz, A.; Valenzuela, C.; Soeller, C.; Comes, N.; Felipe, A. "The unconventional biogenesis of Kv7.1-KCNE1 complexes.". Sci Adv. 6(14): eaay4472. (2020). (PMID: 32270035).
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  22. Lopez-Hurtado, A.; Peraza, D.A.; Cercos, P.; Lagartera, L.; Gonzalez, P.; Dopazo, X.M.; Herranz, R.; Gonzalez, T.; Martin-Martinez, M.; Mellström, B.; Naranjo, J.R.; Valenzuela, C.; Gutierrez-Rodriguez, M. "Targeting the neuronal calcium sensor DREAM with small-molecules for Huntington's disease treatment.". Sci Rep. 9(1): 7260. (2019). (PMID: 31086218).
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  23. Mondéjar-Parreño, G.; Moral-Sanz, J.; Barreira, B.; De la Cruz, A.; Gonzalez, T.; Callejo, M.; Esquivel-Ruiz, S.; Morales-Cano, D.; Moreno, L.; Valenzuela, C.; Perez-Vizcaino, F.; Cogolludo, A. ""Activation of Kv7 channels as a novel mechanism for NO/cGMP-induced pulmonary vasodilation".". Br. J. Pharmacol.. (): . (2019). (PMID: 30883701).
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  24. Peraza, D.A.; Cercós, P.; Miaja, P.; Merinero, Y.G.; Lagartera, L.; Socuéllamos, P.G.; Izquierdo García, C.; Sánchez, S.A.; López-Hurtado, A.; Martín-Martínez, M.; Olivos-Oré, L.A.; Naranjo, J.R.; Artalejo, A.R.; Gutiérrez-Rodríguez, M.; Valenzuela, C. "Identification of IQM-266, a Novel DREAM Ligand That Modulates KV4 Currents.". Front Mol Neurosci. 12(): 11. (2019). (PMID: 30787866).
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  25. Moreno, C.; Oliveras, A.; Bartolucci, C.; Muñoz, C.; de la Cruz, A.; Peraza, D.A.; Gimeno, J.R.; Martín-Martínez, M.; Severi, S.; Felipe, A.; Lambiase, P.D.; González, T.; Valenzuela, C. "Corrigendum to Supplemental Material: 'D242N, a KV7.1 LQTS mutation uncovers a key residue for IKs voltage dependence' [Journal of Molecular and Cellular Cardiology, Volume 110, September 2017, Pages 61-69].". J. Mol. Cell. Cardiol.. 128(): 25. (2019). (PMID: 30682566).
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  26. Khemili, D.; Valenzuela, C.; Laraba-Djebari, F.; Hammoudi-Triki, D. "Differential effect of Androctonus australis hector venom components on macrophage KV channels: electrophysiological characterization.". Eur. Biophys. J.. 48(1): 1-13. (2019). (PMID: 30006779).
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  27. Moreno, C.; Oliveras, A.; Bartolucci, C.; Muñoz, C.; de la Cruz, A.; Peraza, D.A.; Gimeno, J.R.; Martín-Martínez, M.; Severi, S.; Felipe, A.; Lambiase, P.D.; Gonzalez, T.; Valenzuela, C. "D242N, a KV7.1 LQTS mutation uncovers a key residue for IKs voltage dependence.". J. Mol. Cell. Cardiol.. 110(): 61-69. (2017). (PMID: 28739325).
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  28. de la Cruz, A.; Vera-Zambrano, A.; Peraza, D.A.; Valenzuela, C.; Zapata, J.M.; Perez-Chacon, G.; Gonzalez, T. "Fludarabine Inhibits KV1.3 Currents in Human B Lymphocytes.". Front Pharmacol. 8(): 177. (2017). (PMID: 28408885).
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  29. Moreno, C.; de la Cruz, A.; Valenzuela, C. "In-Depth Study of the Interaction, Sensitivity, and Gating Modulation by PUFAs on K(+) Channels; Interaction and New Targets.". Front Physiol. 7(): 578. (2016). (PMID: 27933000).
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  30. Valenzuela, C. "M-channels and n-3 polyunsaturated fatty acids: role in pain and epilepsy.". Acta Physiol (Oxf). 218(1): 7-9. (2016). (PMID: 27287186).
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  31. Naranjo, J.R.; Zhang, H.; Villar, D.; González, P.; Dopazo, X.M.; Morón-Oset, J.; Higueras, E.; Oliveros, J.C.; Arrabal, M.D.; Prieto, A.; Cercós, P.; González, T.; De la Cruz, A.; Casado-Vela, J.; Rábano, A.; Valenzuela, C.; Gutierrez-Rodriguez, M.; Li, J.Y.; Mellström, B. "Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease.". J. Clin. Invest.. (): . (2016). (PMID: 26752648).
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  32. Molina-Guijarro, J.M.; García, C.; Macías, Á.; García-Fernández, L.F.; Moreno, C.; Reyes, F.; Martínez-Leal, J.F.; Fernández, R.; Martínez, V.; Valenzuela, C.; Lillo, M.P.; Galmarini, C.M. "Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death.". PLoS ONE. 10(10): e0140782. (2015). (PMID: 26474061).
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  33. Moreno, C.; Oliveras, A.; de la Cruz, A.; Bartolucci, C.; Muñoz, C.; Salar, E.; Gimeno, J.R.; Severi, S.; Comes, N.; Felipe, A.; González, T.; Lambiase, P.; Valenzuela, C. "A new KCNQ1 mutation at the S5 segment that impairs its association with KCNE1 is responsible for short QT syndrome.". Cardiovasc. Res.. 107(4): 613-623. (2015). (PMID: 26168993).
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  34. Moreno, C.; de la Cruz, A.; Oliveras, A.; Kharche, S.R.; Guizy, M.; Comes, N.; Starý, T.; Ronchi, C.; Rocchetti, M.; Baró, I.; Loussouarn, G.; Zaza, A.; Severi, S.; Felipe, A.; Valenzuela, C. "Marine n-3 PUFAs modulate IKs gating, channel expression, and location in membrane microdomains.". Cardiovasc. Res.. 105(2): 223-232. (2015). (PMID: 25497550).
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  35. Macías, A.; de la Cruz, A.; Prieto, A.; Peraza, D.A.; Tamkun, M.M.; González, T.; Valenzuela, C. "PKC inhibition results in a Kv 1.5 + Kv β1.3 pharmacology closer to Kv 1.5 channels.". Br. J. Pharmacol.. 171(21): 4914-4926. (2014). (PMID: 24946104).
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  36. Oliveras, A.; Roura-Ferrer, M.; Solé, L.; de la Cruz, A.; Prieto, A.; Etxebarria, A.; Manils, J.; Morales-Cano, D.; Condom, E.; Soler, C.; Cogolludo, A.; Valenzuela, C.; Villarroel, A.; Comes, N.; Felipe, A. "Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology.". Arterioscler. Thromb. Vasc. Biol.. 34(7): 1522-1530. (2014). (PMID: 24855057).
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  37. Moreno, C.; Prieto, P.; Macías, Á.; Pimentel-Santillana, M.; de la Cruz, A.; Través, P.G.; Boscá, L.; Valenzuela, C. "Modulation of voltage-dependent and inward rectifier potassium channels by 15-epi-lipoxin-A4 in activated murine macrophages: implications in innate immunity.". J. Immunol.. 191(12): 6136-6146. (2013). (PMID: 24249731).
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  38. Valenzuela, C.; Moreno, C.; de la Cruz, A.; Macías, Á.; Prieto, Á.; González, T. "Stereoselective interactions between local anesthetics and ion channels.". Chirality. 24(11): 944-950. (2012). (PMID: 22674834).
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  39. Moreno, C.; Macias, A.; Prieto, A.; De La Cruz, A.; Valenzuela, C. "Polyunsaturated Fatty acids modify the gating of kv channels.". Front Pharmacol. 3(): 163. (2012). (PMID: 22973228).
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  40. Valenzuela, C. "Female gender: risk factor for congenital long QT-related arrhythmias.". Cardiovasc. Res.. 95(3): 263-264. (2012). (PMID: 22721991).
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  41. Moreno, C.; Macías, A.; Prieto, A.; de la Cruz, A.; González, T.; Valenzuela, C. "Effects of n-3 Polyunsaturated Fatty Acids on Cardiac Ion Channels.". Front Physiol. 3(): 245. (2012). (PMID: 22934003).
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  42. David, M.; Macías, Á.; Moreno, C.; Prieto, Á.; Martínez-Mármol, R.; Vicente, R.; González, T.; Felipe, A.; Tamkun, M.M.; Valenzuela, C. "Protein kinase C (PKC) activity regulates functional effects of Kvβ1.3 subunit on KV1.5 channels: identification of a cardiac Kv1.5 channelosome.". J. Biol. Chem.. 287(25): 21416-21428. (2012). (PMID: 22547057).
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  43. Moral-Sanz, J.; Gonzalez, T.; Menendez, C.; David, M.; Moreno, L.; Macias, A.; Cortijo, J.; Valenzuela, C.; Perez-Vizcaino, F.; Cogolludo, A. "Ceramide inhibits Kv currents and contributes to TP-receptor-induced vasoconstriction in rat and human pulmonary arteries.". Am. J. Physiol., Cell Physiol.. 301(1): C186-94. (2011). (PMID: 21490312).
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  44. Molina-Guijarro, J.M.; Macías, Á.; García, C.; Muñoz, E.; García-Fernández, L.F.; David, M.; Núñez, L.; Martínez-Leal, J.F.; Moneo, V.; Cuevas, C.; Lillo, M.P.; Villalobos Jorge, C.; Valenzuela, C.; Galmarini, C.M. "Irvalec inserts into the plasma membrane causing rapid loss of integrity and necrotic cell death in tumor cells.". PLoS ONE. 6(4): e19042. (2011). (PMID: 21556352).
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  45. Macías, A.; Moreno, C.; Moral-Sanz, J.; Cogolludo, A.; David, M.; Alemanni, M.; Pérez-Vizcaíno, F.; Zaza, A.; Valenzuela, C.; González, T. "Celecoxib blocks cardiac Kv1.5, Kv4.3 and Kv7.1 (KCNQ1) channels: effects on cardiac action potentials.". J. Mol. Cell. Cardiol.. 49(6): 984-992. (2010). (PMID: 20858500).
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  46. Villalonga, N.; David, M.; Bielańska, J.; González, T.; Parra, D.; Soler, C.; Comes, N.; Valenzuela, C.; Felipe, A. "Immunomodulatory effects of diclofenac in leukocytes through the targeting of Kv1.3 voltage-dependent potassium channels.". Biochem. Pharmacol.. 80(6): 858-866. (2010). (PMID: 20488163).
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  47. González, T.; David, M.; Moreno, C.; Macías, A.; Valenzuela, C. "Kv1.5-Kv beta interactions: molecular determinants and pharmacological consequences.". Mini Rev Med Chem. 10(7): 635-642. (2010). (PMID: 20500153).
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  48. Villalonga, N.; David, M.; Bielanska, J.; Vicente, R.; Comes, N.; Valenzuela, C.; Felipe, A. "Immunomodulation of voltage-dependent K+ channels in macrophages: molecular and biophysical consequences.". J. Gen. Physiol.. 135(2): 135-147. (2010). (PMID: 20100893).
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  49. Dujardin, K.S.; Dumotier, B.; David, M.; Guizy, M.; Valenzuela, C.; Hondeghem, L.M. "Ultrafast sodium channel block by dietary fish oil prevents dofetilide-induced ventricular arrhythmias in rabbit hearts.". Am. J. Physiol. Heart Circ. Physiol.. 295(4): H1414-21. (2008). (PMID: 18676685).
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  50. Villalonga, N.; Martínez-Mármol, R.; Roura-Ferrer, M.; David, M.; Valenzuela, C.; Soler, C.; Felipe, A. "Cell cycle-dependent expression of Kv1.5 is involved in myoblast proliferation.". Biochim. Biophys. Acta. 1783(5): 728-736. (2008). (PMID: 18230363).
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  51. David, M.; Martínez-Mármol, R.; Gonzalez, T.; Felipe, A.; Valenzuela, C. "Differential regulation of Na(v)beta subunits during myogenesis.". Biochem. Biophys. Res. Commun.. 368(3): 761-766. (2008). (PMID: 18261980).
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  52. Guizy, M.; David, M.; Arias, C.; Zhang, L.; Cofán, M.; Ruiz-Gutiérrez, V.; Ros, E.; Lillo, M.P.; Martens, J.R.; Valenzuela, C. "Modulation of the atrial specific Kv1.5 channel by the n-3 polyunsaturated fatty acid, alpha-linolenic acid.". J. Mol. Cell. Cardiol.. 44(2): 323-335. (2008). (PMID: 18155022).
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  53. Martínez-Mármol, R.; David, M.; Sanches, R.; Roura-Ferrer, M.; Villalonga, N.; Sorianello, E.; Webb, S.M.; Zorzano, A.; Gumà, A.; Valenzuela, C.; Felipe, A. "Voltage-dependent Na+ channel phenotype changes in myoblasts. Consequences for cardiac repair.". Cardiovasc. Res.. 76(3): 430-441. (2007). (PMID: 17900547).
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  54. Arias, C.; Guizy, M.; David, M.; Marzian, S.; González, T.; Decher, N.; Valenzuela, C. "Kvbeta1.3 reduces the degree of stereoselective bupivacaine block of Kv1.5 channels.". Anesthesiology. 107(4): 641-651. (2007). (PMID: 17893461).
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  55. Arias, C.; Guizy, M.; Luque-Ortega, J.R.; Guerrero, E.; de la Torre, B.G.; Andreu, D.; Rivas, L.; Valenzuela, C. "The induction of NOS2 expression by the hybrid cecropin A-melittin antibiotic peptide CA(1-8)M(1-18) in the monocytic line RAW 264.7 is triggered by a temporary and reversible plasma membrane permeation.". Biochim. Biophys. Acta. 1763(1): 110-119. (2006). (PMID: 16377003).
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  56. Guizy, M.; Arias, C.; David, M.; González, T.; Valenzuela, C. "{Omega}-3 and {omega}-6 polyunsaturated fatty acids block HERG channels.". Am. J. Physiol., Cell Physiol.. 289(5): C1251-60. (2005). (PMID: 15987770).
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  57. Caballero, R.; Gómez, R.; Moreno, I.; Nuñez, L.; González, T.; Arias, C.; Guizy, M.; Valenzuela, C.; Tamargo, J.; Delpón, E. "Interaction of angiotensin II with the angiotensin type 2 receptor inhibits the cardiac transient outward potassium current.". Cardiovasc. Res.. 62(1): 86-95. (2004). (PMID: 15023555).
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  58. Tamargo, J.; Caballero, R.; Gómez, R.; Valenzuela, C.; Delpón, E. "Pharmacology of cardiac potassium channels.". Cardiovasc. Res.. 62(1): 9-33. (2004). (PMID: 15023549).
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  59. Valenzuela, C. "Pharmacological electrical remodelling in human atria induced by chronic beta-blockade.". Cardiovasc. Res.. 58(3): 498-500. (2003). (PMID: 12798421).
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  60. Arias, C.; González, T.; Moreno, I.; Caballero, R.; Delpón, E.; Tamargo, J.; Valenzuela, C. "Effects of propafenone and its main metabolite, 5-hydroxypropafenone, on HERG channels.". Cardiovasc. Res.. 57(3): 660-669. (2003). (PMID: 12618228).
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  61. Moreno, I.; Caballero, R.; González, T.; Arias, C.; Valenzuela, C.; Iriepa, I.; Gálvez, E.; Tamargo, J.; Delpón, E. "Effects of irbesartan on cloned potassium channels involved in human cardiac repolarization.". J. Pharmacol. Exp. Ther.. 304(2): 862-873. (2003). (PMID: 12538844).
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  62. Caballero, R.; Moreno, I.; González, T.; Arias, C.; Valenzuela, C.; Delpón, E.; Tamargo, J. "Spironolactone and its main metabolite, canrenoic acid, block human ether-a-go-go-related gene channels.". Circulation. 107(6): 889-895. (2003). (PMID: 12591761).
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  63. González, T.; Navarro-Polanco, R.; Arias, C.; Caballero, R.; Moreno, I.; Delpón, E.; Tamargo, J.; Tamkun, M.M.; Valenzuela, C. "Assembly with the Kvbeta1.3 subunit modulates drug block of hKv1.5 channels.". Mol. Pharmacol.. 62(6): 1456-1463. (2002). (PMID: 12435814).
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  64. González, T.; Arias, C.; Caballero, R.; Moreno, I.; Delpón, E.; Tamargo, J.; Valenzuela, C. "Effects of levobupivacaine, ropivacaine and bupivacaine on HERG channels: stereoselective bupivacaine block.". Br. J. Pharmacol.. 137(8): 1269-1279. (2002). (PMID: 12466236).
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  65. Caballero, R.; Moreno, I.; González, T.; Valenzuela, C.; Tamargo, J.; Delpón, E. "Putative binding sites for benzocaine on a human cardiac cloned channel (Kv1.5).". Cardiovasc. Res.. 56(1): 104-117. (2002). (PMID: 12237171).
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  66. Longobardo, M.; González, T.; Caballero, R.; Delpón, E.; Tamargo, J.; Valenzuela, C. "Bupivacaine effects on hKv1.5 channels are dependent on extracellular pH.". Br. J. Pharmacol.. 134(2): 359-369. (2001). (PMID: 11564654).
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  67. Caballero, R.; Delpón, E.; Valenzuela, C.; Longobardo, M.; González, T.; Tamargo, J. "Direct effects of candesartan and eprosartan on human cloned potassium channels involved in cardiac repolarization.". Mol. Pharmacol.. 59(4): 825-836. (2001). (PMID: 11259627).
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  68. González, T.; Longobardo, M.; Caballero, R.; Delpón, E.; Tamargo, J.; Valenzuela, C. "Effects of bupivacaine and a novel local anesthetic, IQB-9302, on human cardiac K+ channels.". J. Pharmacol. Exp. Ther.. 296(2): 573-583. (2001). (PMID: 11160646).
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  69. González, T.; Longobardo, M.; Caballero, R.; Delpón, E.; Sinisterra, J.V.; Tamargo, J.; Valenzuela, C. "Stereoselective effects of the enantiomers of a new local anaesthetic, IQB-9302, on a human cardiac potassium channel (Kv1.5).". Br. J. Pharmacol.. 132(2): 385-392. (2001). (PMID: 11159686).
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  70. Longobardo, M.; González, T.; Navarro-Polanco, R.; Caballero, R.; Delpón, E.; Tamargo, J.; Snyders, D.J.; Tamkun, M.M.; Valenzuela, C. "Effects of a quaternary bupivacaine derivative on delayed rectifier K(+) currents.". Br. J. Pharmacol.. 130(2): 391-401. (2000). (PMID: 10807678).
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  71. Caballero, R.; Delpón, E.; Valenzuela, C.; Longobardo, M.; Tamargo, J. "Losartan and its metabolite E3174 modify cardiac delayed rectifier K(+) currents.". Circulation. 101(10): 1199-1205. (2000). (PMID: 10715269).
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  72. Delpón, E.; Valenzuela, C.; Tamargo, J. "Blockade of cardiac potassium and other channels by antihistamines.". Drug Saf. 21 Suppl 1(): 11-8; discussion 81-7. (1999). (PMID: 10597864).
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  73. Caballero, R.; Valenzuela, C.; Longobardo, M.; Tamargo, J.; Delpón, E. "Effects of rupatadine, a new dual antagonist of histamine and platelet-activating factor receptors, on human cardiac kv1.5 channels.". Br. J. Pharmacol.. 128(5): 1071-1081. (1999). (PMID: 10556945).
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  74. Delpón, E.; Caballero, R.; Valenzuela, C.; Longobardo, M.; Snyders, D.; Tamargo, J. "Benzocaine enhances and inhibits the K+ current through a human cardiac cloned channel (Kv1.5).". Cardiovasc. Res.. 42(2): 510-520. (1999). (PMID: 10533586).
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    CONCLUSIONS
    All these results suggest that benzocaine blocks and modifies the voltage- and time-dependent properties of hKv1.5 channels, binding to an extracellular and to an intracellular site at the channel level. Moreover, both sites are related to each other and can also interact with K+.

    ')" value="Abstract">

  75. Franqueza, L.; Valenzuela, C.; Eck, J.; Tamkun, M.M.; Tamargo, J.; Snyders, D.J. "Functional expression of an inactivating potassium channel (Kv4.3) in a mammalian cell line.". Cardiovasc. Res.. 41(1): 212-219. (1999). (PMID: 10325968).
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  76. Franqueza, L.; Valenzuela, C.; Delpón, E.; Longobardo, M.; Caballero, R.; Tamargo, J. "Effects of propafenone and 5-hydroxy-propafenone on hKv1.5 channels.". Br. J. Pharmacol.. 125(5): 969-978. (1998). (PMID: 9846634).
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  77. Longobardo, M.; Delpón, E.; Caballero, R.; Tamargo, J.; Valenzuela, C. "Structural determinants of potency and stereoselective block of hKv1.5 channels induced by local anesthetics.". Mol. Pharmacol.. 54(1): 162-169. (1998). (PMID: 9658202).
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  78. Franqueza, L.; Longobardo, M.; Vicente, J.; Delpón, E.; Tamkun, M.M.; Tamargo, J.; Snyders, D.J.; Valenzuela, C. "Molecular determinants of stereoselective bupivacaine block of hKv1.5 channels.". Circ. Res.. 81(6): 1053-1064. (1997). (PMID: 9400387).
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  79. Caballero, R.; Delpón, E.; Valenzuela, C.; Longobardo, M.; Franqueza, L.; Tamargo, J. "Effect of descarboethoxyloratadine, the major metabolite of loratadine, on the human cardiac potassium channel Kv1.5.". Br. J. Pharmacol.. 122(5): 796-798. (1997). (PMID: 9384491).
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  80. Delpón, E.; Valenzuela, C.; Gay, P.; Franqueza, L.; Snyders, D.J.; Tamargo, J. "Block of human cardiac Kv1.5 channels by loratadine: voltage-, time- and use-dependent block at concentrations above therapeutic levels.". Cardiovasc. Res.. 35(2): 341-350. (1997). (PMID: 9349397).
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  81. Valenzuela, C.; Delpón, E.; Franqueza, L.; Gay, P.; Vicente, J.; Tamargo, J. "Comparative effects of nonsedating histamine H1 receptor antagonists, ebastine and terfenadine, on human Kv1.5 channels.". Eur. J. Pharmacol.. 326(2-3): 257-263. (1997). (PMID: 9196279).
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  82. Valenzuela, C.; Delpón, E.; Franqueza, L.; Gay, P.; Snyders, D.J.; Tamargo, J. "Effects of ropivacaine on a potassium channel (hKv1.5) cloned from human ventricle.". Anesthesiology. 86(3): 718-728. (1997). (PMID: 9066339).
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    CONCLUSIONS
    These results indicate that: (1) ropivacaine is an open channel blocker of hKv1.5; (2) binding occurs in the internal mouth of the ion pore; and (3) unbinding is required before the channel can close. These effects explain the ropivacaine availability of induction early after depolarizations and could be clinically relevant.

    ')" value="Abstract">

  83. Pérez, O.; Valenzuela, C.; Delpón, E.; Tamargo, J. "Electrophysiological effects of CI-980, a tubulin binding agent, on guinea-pig papillary muscles.". Br. J. Pharmacol.. 120(2): 187-192. (1997). (PMID: 9117108).
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  84. Valenzuela, C.; Delpón, E.; Franqueza, L.; Gay, P.; Pérez, O.; Tamargo, J.; Snyders, D.J. "Class III antiarrhythmic effects of zatebradine. Time-, state-, use-, and voltage-dependent block of hKv1.5 channels.". Circulation. 94(3): 562-570. (1996). (PMID: 8759103).
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    CONCLUSIONS
    These results indicate that (1) zatebradine is an open-channel blocker of hKv 1.5, (2) binding occurs in the internal mouth of the ion pore, (3) unbinding is required before the channel can close, and (4) zatebradine-induced block is use dependent because of slower recovery kinetics in the presence of the drug. These effects may explain the prolongation of the cardiac action potential and could be clinically relevant.

    ')" value="Abstract">

  85. Delpón, E.; Valenzuela, C.; Pérez, O.; Franqueza, L.; Gay, P.; Snyders, D.J.; Tamargo, J. "Mechanisms of block of a human cloned potassium channel by the enantiomers of a new bradycardic agent: S-16257-2 and S-16260-2.". Br. J. Pharmacol.. 117(6): 1293-1301. (1996). (PMID: 8882628).
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  86. Valenzuela, C.; Snyders, D.J.; Bennett, P.B.; Tamargo, J.; Hondeghem, L.M. "Stereoselective block of cardiac sodium channels by bupivacaine in guinea pig ventricular myocytes.". Circulation. 92(10): 3014-3024. (1995). (PMID: 7586272).
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  87. Bennett, P.B.; Valenzuela, C.; Chen, L.Q.; Kallen, R.G. "On the molecular nature of the lidocaine receptor of cardiac Na+ channels. Modification of block by alterations in the alpha-subunit III-IV interdomain.". Circ. Res.. 77(3): 584-592. (1995). (PMID: 7641328).
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  88. Valenzuela, C.; Delpón, E.; Tamkun, M.M.; Tamargo, J.; Snyders, D.J. "Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers.". Biophys. J.. 69(2): 418-427. (1995). (PMID: 8527655).
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  89. Pérez, O.; Gay, P.; Franqueza, L.; Carrón, R.; Valenzuela, C.; Delpón, E.; Tamargo, J. "Effects of the two enantiomers, S-16257-2 and S-16260-2, of a new bradycardic agent on guinea-pig isolated cardiac preparations.". Br. J. Pharmacol.. 115(5): 787-794. (1995). (PMID: 8548178).
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  90. Pérez, O.; Gay, P.; Franqueza, L.; Carrón, R.; Valenzuela, C.; Delpón, E.; Tamargo, J. "Electromechanical effects of zatebradine on isolated guinea pig cardiac preparations.". J. Cardiovasc. Pharmacol.. 26(1): 46-54. (1995). (PMID: 7564364).
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  91. Delpón, E.; Valenzuela, C.; Pérez, O.; Casis, O.; Tamargo, J. "Propafenone preferentially blocks the rapidly activating component of delayed rectifier K+ current in guinea pig ventricular myocytes. Voltage-independent and time-dependent block of the slowly activating component.". Circ. Res.. 76(2): 223-235. (1995). (PMID: 7834833).
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  92. Valenzuela, C.; Pérez, O.; Delpón, E.; Tamargo, J. "Effects of lisinopril on cardiac contractility and ionic currents.". Gen. Pharmacol.. 25(5): 825-832. (1994). (PMID: 7835625).
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  93. Valenzuela, C.; Bennett, P.B. "Gating of cardiac Na+ channels in excised membrane patches after modification by alpha-chymotrypsin.". Biophys. J.. 67(1): 161-171. (1994). (PMID: 7918983).
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  94. Valenzuela, C.; Sánchez-Chapula, J.; Delpón, E.; Elizalde, A.; Pérez, O.; Tamargo, J. "Imipramine blocks rapidly activating and delays slowly activating K+ current activation in guinea pig ventricular myocytes.". Circ. Res.. 74(4): 687-699. (1994). (PMID: 8137505).
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  95. Pérez, O.; Valenzuela, C.; Delpón, E.; Tamargo, J. "Class I and III antiarrhythmic actions of prazosin in guinea-pig papillary muscles.". Br. J. Pharmacol.. 111(3): 717-722. (1994). (PMID: 8019750).
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  96. Tamargo, J.; Delpón, E.; Valenzuela, C. "Treatment of left ventricular hypertrophy in hypertensive patients.". Eur. Heart J.. 14 Suppl J(): 102-106. (1993). (PMID: 8281952).
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  97. Valenzuela, C.; Pérez, O.; Casis, O.; Duarte, J.; Pérez-Vizcaino, F.; Delpón, E.; Tamargo, J. "Effects of lisinopril on electromechanical properties and membrane currents in guinea-pig cardiac preparations.". Br. J. Pharmacol.. 109(3): 873-879. (1993). (PMID: 7689408).
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  98. Tamargo, J.; Delpón, E.; Valenzuela, C.; Pérez, O. "[Anti-arrhythmia agents: classification, mode of action, and therapeutic usefulness].". Rev Clin Esp. 192(4): 189-196. (1993). (PMID: 8386844).
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  99. Tamargo, J.; Valenzuela, C.; Delpón, E. "[Cardiac arrhythmias (III). The classification of anti-arrhythmia drugs in the 90s: a focus for the cardiologist].". Rev Esp Cardiol. 46(3): 183-194. (1993). (PMID: 8387683).
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  100. Delpón, E.; Valenzuela, C.; Pérez, O.; Tamargo, J. "Electrophysiological effects of the combination of imipramine and desipramine in guinea pig papillary muscles.". J. Cardiovasc. Pharmacol.. 21(1): 13-20. (1993). (PMID: 7678668).
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  101. Tamargo, J.; Valenzuela, C.; Delpón, E. "New insights into the pharmacology of sodium channel blockers.". Eur. Heart J.. 13 Suppl F(): 2-13. (1992). (PMID: 1335869).
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  102. Delpón, E.; Valenzuela, C.; Pérez, O.; Tamargo, J. "Electrophysiological effects of CRE-1087 in guinea-pig ventricular muscles.". Br. J. Pharmacol.. 107(2): 515-520. (1992). (PMID: 1422597).
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  103. Delpón, E.; Valenzuela, C.; Tamargo, J. "Electrophysiological effects of the combination of mexiletine and flecainide in guinea-pig ventricular fibres.". Br. J. Pharmacol.. 103(2): 1411-1416. (1991). (PMID: 1909200).
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  104. Delpón, E.; Valenzuela, C.; Carrón, R.; Pérez-Vizcaino, F.; Tamargo, J. "Tonic and frequency-dependent Vmax block induced by (S)-nafenodone, a new antidepressant drug, in guinea-pig papillary muscles.". Naunyn Schmiedebergs Arch. Pharmacol.. 343(6): 638-644. (1991). (PMID: 1944605).
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  105. Valenzuela, C.; Bennett, P.B. "Voltage- and use-dependent modulation of calcium channel current in guinea pig ventricular cells by amiodarone and des-oxo-amiodarone.". J. Cardiovasc. Pharmacol.. 17(6): 894-902. (1991). (PMID: 1714012).
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  106. Delpón, E.; Valenzuela, C.; Tamargo, J. "Tonic and frequency-dependent Vmax block induced by imipramine in guinea pig ventricular muscle fibers.". J. Cardiovasc. Pharmacol.. 15(3): 414-420. (1990). (PMID: 1691365).
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  107. Tamargo, J.; Valenzuela, C.; Delpón, E. "[Amiodarone: new concepts on its anti-arrhythmic effect].". An Med Interna. 7(1): 42-50. (1990). (PMID: 2103198).
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  108. Valenzuela, C.; Sanchez-Chapula, J. "Electrophysiologic interactions between mexiletine-quinidine and mexiletine-ropitoin in guinea pig papillary muscle.". J. Cardiovasc. Pharmacol.. 14(5): 783-789. (1989). (PMID: 2481194).
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  109. Valenzuela, C.; Delpón, E.; Tamargo, J. "Electrophysiologic interactions between mexiletine and propafenone in guinea pig papillary muscles.". J. Cardiovasc. Pharmacol.. 14(3): 351-357. (1989). (PMID: 2476612).
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  110. Delpón, E.; Valenzuela, C.; Tamargo, J. "Electrophysiological effects of E-3753, a new antiarrhythmic drug, in guinea-pig ventricular muscle.". Br. J. Pharmacol.. 96(4): 970-976. (1989). (PMID: 2743087).
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  111. Valenzuela, C.; Delpón, E.; Tamargo, J. "Tonic and phasic Vmax block induced by 5-hydroxypropafenone in guinea pig ventricular muscles.". J. Cardiovasc. Pharmacol.. 12(4): 423-431. (1988). (PMID: 2465442).
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  112. Manzanares, J.; Valenzuela, C.; Delgado, C.; Tamargo, J. "Comparison of six new antidepressants on isolated rat atria.". Arzneimittelforschung. 38(6): 805-809. (1988). (PMID: 3178921).
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  113. Valenzuela, C.; Delgado, C.; Tamargo, J. "Electrophysiological effects of 5-hydroxypropafenone on guinea pig ventricular muscle fibers.". J. Cardiovasc. Pharmacol.. 10(5): 523-529. (1987). (PMID: 2447400).
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  114. Tejerina, T.; Delgado, C.; Valenzuela, C.; Tamargo, J. "Comparative effects of oxodipine and nifedipine in the isolated guinea-pig heart.". Arch Int Pharmacodyn Ther. 288(2): 186-199. (1987). (PMID: 3675081).
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  115. Delgado, C.; Tamargo, J.; Tejerina, T.; Valenzuela, C. "Effects of 5-hydroxy-propafenone in guinea-pig atrial fibres.". Br. J. Pharmacol.. 90(3): 575-582. (1987). (PMID: 2882804).
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  116. Delgado, C.; Manzanares, J.; Tamargo, J.; Valenzuela, C. "Electrophysiological effects of amoxapine in untreated and in amoxapine-pretreated rat atria.". Br. J. Pharmacol.. 87(2): 317-325. (1986). (PMID: 3955303).
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  117. Diez, J.; Tamargo, J.; Valenzuela, C. "Negative inotropic effect of somatostatin in guinea-pig atrial fibres.". Br. J. Pharmacol.. 86(3): 547-555. (1985). (PMID: 2866001).
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