Collado, M.; Castillo, M.; Muñoz de Mier, G.J.; de la Pinta, C.; Peña, C. "The Diet as a Modulator of Tumor Microenvironment in Colorectal Cancer Patients.". Int J Mol Sci. 24(8): . (2023). (PMID: 37108477).
Galindo-Pumariño, C.; Collado, M.; Castillo, M.E.; Barquín, J.; Romio, E.; Larriba, M.J.; Muñoz de Mier, G.J.; Carrato, A.; de la Pinta, C.; Pena, C. "SNAI1-expressing fibroblasts and derived-extracellular matrix as mediators of drug resistance in colorectal cancer patients.". Toxicol Appl Pharmacol. (): 116171. (2022). (PMID: 35878797).
de la Pinta, C.; Castillo, M.E.; Collado, M.; Galindo-Pumariño, C.; Peña, C. "Radiogenomics: Hunting Down Liver Metastasis in Colorectal Cancer Patients.". Cancers (Basel). 13(21): . (2021). (PMID: 34771709).
Llorens, C.; Soriano, B.; Trilla-Fuertes, L.; Bagan, L.; Ramos-Ruiz, R.; Gamez-Pozo, A.; Peña, C.; Bagan, J.V. "Immune expression profile identification in a group of proliferative verrucous leukoplakia patients: a pre-cancer niche for oral squamous cell carcinoma development.". Clin Oral Investig. 25(5): 2645-2657. (2021). (PMID: 32918120).
Herrera, M.; Berral-González, A.; López-Cade, I.; Galindo-Pumariño, C.; Bueno-Fortes, S.; Martín-Merino, M.; Carrato, A.; Ocaña, A.; De La Pinta, C.; López-Alfonso, A.; Peña, C.; García-Barberán, V.; De Las Rivas, J. "Cancer-associated fibroblast-derived gene signatures determine prognosis in colon cancer patients.". Mol Cancer. 20(1): 73. (2021). (PMID: 33926453).
Galindo-Pumariño, C.; Collado, M.; Herrera, M.; Peña, C. "Tumor Microenvironment in Metastatic Colorectal Cancer: The Arbitrator in Patients' Outcome.". Cancers (Basel). 13(5): . (2021). (PMID: 33800796).
Galindo-Pumariño, C.; Herrera, A.; Muñoz, A.; Carrato, A.; Herrera, M.; Peña, C. "Fibroblast-Derived 3D Matrix System Applicable to Endothelial Tube Formation Assay.". J Vis Exp. (154): . (2019). (PMID: 31929503).
Herrera, M.; Galindo-Pumariño, C.; García-Barberán, V.; Peña, C. "A Snapshot of The Tumor Microenvironment in Colorectal Cancer: The Liquid Biopsy.". Int J Mol Sci. 20(23): . (2019). (PMID: 31795332).
Landskron, G.; De la Fuente López, M.; Dubois-Camacho, K.; Díaz-Jiménez, D.; Orellana-Serradell, O.; Romero, D.; Sepúlveda, S.A.; Salazar, C.; Parada-Venegas, D.; Quera, R.; Simian, D.; González, M.J.; López-Köstner, F.; Kronberg, U.; Abedrapo, M.; Gallegos, I.; Contreras, H.R.; Peña, C.; Díaz-Araya, G.; Roa, J.C.; Hermoso, M.A. "Interleukin 33/ST2 Axis Components Are Associated to Desmoplasia, a Metastasis-Related Factor in Colorectal Cancer.". Front Immunol. 10(): 1394. (2019). (PMID: 31281317).
Herrera, A.; Herrera, M.; Guerra-Perez, N.; Galindo-Pumariño, C.; Larriba, M.J.; García-Barberán, V.; Gil, B.; Giménez-Moyano, S.; Ferreiro-Monteagudo, R.; Veguillas, P.; Candia, A.; Peña, R.; Pinto, J.; García-Bermejo, M.L.; Muñoz, A.; García de Herreros, A.; Bonilla, F.; Carrato, A.; Peña, C. "Endothelial cell activation on 3D-matrices derived from PDGF-BB-stimulated fibroblasts is mediated by Snail1.". Oncogenesis. 7(9): 76. (2018). (PMID: 30250018).
Herrera, M.; Llorens, C.; Rodríguez, M.; Herrera, A.; Ramos, R.; Gil, B.; Candia, A.; Larriba, M.J.; Garre, P.; Earl, J.; Rodríguez-Garrote, M.; Caldés, T.; Bonilla, F.; Carrato, A.; García-Barberán, V.; Peña, C. "Differential distribution and enrichment of non-coding RNAs in exosomes from normal and Cancer-associated fibroblasts in colorectal cancer.". Mol. Cancer. 17(1): 114. (2018). (PMID: 30075793).
Alba-Castellón, L.; Olivera-Salguero, R.; Mestre-Farrera, A.; Peña, R.; Herrera, M.; Bonilla, F.; Casal, J.I.; Baulida, J.; Peña, C.; García de Herreros, A. "Snail1-Dependent Activation of Cancer-Associated Fibroblast Controls Epithelial Tumor Cell Invasion and Metastasis.". Cancer Res. 76(21): 6205-6217. (2016). (PMID: 27503928).
García-Palmero, I.; Torres, S.; Bartolomé, R.A.; Peláez-García, A.; Larriba, M.J.; Lopez-Lucendo, M.; Peña, C.; Escudero-Paniagua, B.; Muñoz, A.; Casal, J.I. "Twist1-induced activation of human fibroblasts promotes matrix stiffness by upregulating palladin and collagen α1(VI).". Oncogene. 35(40): 5224-5236. (2016). (PMID: 26973246).
Herrera, A.; Herrera, M.; Peña, C. "The emerging role of Snail1 in the tumor stroma.". Clin Transl Oncol. 18(9): 872-877. (2016). (PMID: 26687368).
Rodríguez, M.; Silva, J.; Herrera, A.; Herrera, M.; Peña, C.; Martín, P.; Gil-Calderón, B.; Larriba, M.J.; Coronado, M.J.; Soldevilla, B.; Turrión, V.S.; Provencio, M.; Sánchez, A.; Bonilla, F.; García-Barberán, V. "Exosomes enriched in stemness/metastatic-related mRNAS promote oncogenic potential in breast cancer.". Oncotarget. 6(38): 40575-40587. (2015). (PMID: 26528758).
Torres, S.; Garcia-Palmero, I.; Herrera, M.; Bartolomé, R.A.; Peña, C.; Fernandez-Aceñero, M.J.; Padilla, G.; Peláez-García, A.; Lopez-Lucendo, M.; Rodriguez-Merlo, R.; García de Herreros, A.; Bonilla, F.; Casal, J.I. "LOXL2 Is Highly Expressed in Cancer-Associated Fibroblasts and Associates to Poor Colon Cancer Survival.". Clin Cancer Res. 21(21): 4892-4902. (2015). (PMID: 26206869).
San Millán, C.; Soldevilla, B.; Martín, P.; Gil-Calderón, B.; Compte, M.; Pérez-Sacristán, B.; Donoso, E.; Peña, C.; Romero, J.; Granado-Lorencio, F.; Bonilla, F.; Domínguez, G. "β-Cryptoxanthin Synergistically Enhances the Antitumoral Activity of Oxaliplatin through ΔNP73 Negative Regulation in Colon Cancer.". Clin. Cancer Res.. 21(19): 4398-4409. (2015). (PMID: 26023082).
Stanisavljevic, J.; Loubat-Casanovas, J.; Herrera, M.; Luque, T.; Peña, R.; Lluch, A.; Albanell, J.; Bonilla, F.; Rovira, A.; Peña, C.; Navajas, D.; Rojo, F.; García de Herreros, A.; Baulida, J. "Snail1-expressing fibroblasts in the tumor microenvironment display mechanical properties that support metastasis.". Cancer Res. 75(2): 284-295. (2015). (PMID: 25488750).
Rodríguez, M.; Silva, J.; López-Alfonso, A.; López-Muñiz, M.B.; Peña, C.; Domínguez, G.; García, J.M.; López-Gónzalez, A.; Méndez, M.; Provencio, M.; García, V.; Bonilla, F. "Different exosome cargo from plasma/bronchoalveolar lavage in non-small-cell lung cancer.". Genes Chromosomes Cancer. 53(9): 713-724. (2014). (PMID: 24764226).
Herrera, A.; Herrera, M.; Alba-Castellón, L.; Silva, J.; García, V.; Loubat-Casanovas, J.; Alvarez-Cienfuegos, A.; Miguel García, J.; Rodriguez, R.; Gil, B.; Ma Jesús Citores, .; Ma Jesús Larriba, .; Ignacio Casal, J.; de Herreros, A.G.; Bonilla, F.; Peña, C. "Protumorigenic effects of Snail-expression fibroblasts on colon cancer cells.". Int. J. Cancer. 134(12): 2984-2990. (2014). (PMID: 24242829).
Herrera, M.; Islam, A.B.; Herrera, A.; Martín, P.; García, V.; Silva, J.; Garcia, J.M.; Salas, C.; Casal, I.; de Herreros, A.G.; Bonilla, F.; Peña, C. "Functional heterogeneity of cancer-associated fibroblasts from human colon tumors shows specific prognostic gene expression signature.". Clin Cancer Res. 19(21): 5914-5926. (2013). (PMID: 24052018).
CONCLUSIONS In summary, these studies show for the first time the heterogeneity of primary CAFs' effect on colon cancer cell migration. A CAF gene expression signature able to classify patients with colon cancer into high- and low-risk groups was identified.
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Torres, S.; Bartolomé, R.A.; Mendes, M.; Barderas, R.; Fernandez-Aceñero, M.J.; Peláez-García, A.; Peña, C.; Lopez-Lucendo, M.; Villar-Vázquez, R.; de Herreros, A.G.; Bonilla, F.; Casal, J.I. "Proteome profiling of cancer-associated fibroblasts identifies novel proinflammatory signatures and prognostic markers for colorectal cancer.". Clin Cancer Res. 19(21): 6006-6019. (2013). (PMID: 24025712).
Frings, O.; Augsten, M.; Tobin, N.P.; Carlson, J.; Paulsson, J.; Pena, C.; Olsson, E.; Veerla, S.; Bergh, J.; Ostman, A.; Sonnhammer, E.L. "Prognostic significance in breast cancer of a gene signature capturing stromal PDGF signaling.". Am J Pathol. 182(6): 2037-2047. (2013). (PMID: 23583284).
Herrera, M.; Herrera, A.; Domínguez, G.; Silva, J.; García, V.; García, J.M.; Gómez, I.; Soldevilla, B.; Muñoz, C.; Provencio, M.; Campos-Martin, Y.; García de Herreros, A.; Casal, I.; Bonilla, F.; Peña, C. "Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients.". Cancer Sci. 104(4): 437-444. (2013). (PMID: 23298232).
Silva, J.; Garcia, V.; Rodriguez, M.; Compte, M.; Cisneros, E.; Veguillas, P.; Garcia, J.M.; Dominguez, G.; Campos-Martin, Y.; Cuevas, J.; Peña, C.; Herrera, M.; Diaz, R.; Mohammed, N.; Bonilla, F. "Analysis of exosome release and its prognostic value in human colorectal cancer.". Genes Chromosomes Cancer. 51(4): 409-418. (2012). (PMID: 22420032).
Soldevilla, B.; Díaz, R.; Silva, J.; Campos-Martín, Y.; Muñoz, C.; García, V.; García, J.M.; Peña, C.; Herrera, M.; Rodriguez, M.; Gómez, I.; Mohamed, N.; Marques, M.M.; Bonilla, F.; Domínguez, G. "Prognostic impact of ΔTAp73 isoform levels and their target genes in colon cancer patients.". Clin Cancer Res. 17(18): 6029-6039. (2011). (PMID: 21807636).
Mohammed, N.; Rodriguez, M.; Garcia, V.; Garcia, J.M.; Dominguez, G.; Peña, C.; Herrera, M.; Gomez, I.; Diaz, R.; Soldevilla, B.; Herrera, A.; Silva, J.; Bonilla, F. "EPAS1 mRNA in plasma from colorectal cancer patients is associated with poor outcome in advanced stages.". Oncol Lett. 2(4): 719-724. (2011). (PMID: 22848255).
Gomez, I.; Peña, C.; Herrera, M.; Muñoz, C.; Larriba, M.J.; Garcia, V.; Dominguez, G.; Silva, J.; Rodriguez, R.; Garcia de Herreros, A.; Bonilla, F.; Garcia, J.M. "TWIST1 is expressed in colorectal carcinomas and predicts patient survival.". PLoS ONE. 6(3): e18023. (2011). (PMID: 21464926).
Silva, J.; García, V.; Zaballos, Á.; Provencio, M.; Lombardía, L.; Almonacid, L.; García, J.M.; Domínguez, G.; Peña, C.; Diaz, R.; Herrera, M.; Varela, A.; Bonilla, F. "Vesicle-related microRNAs in plasma of nonsmall cell lung cancer patients and correlation with survival.". Eur Respir J. 37(3): 617-623. (2011). (PMID: 20595154).
Díaz, R.; González-Sancho, J.M.; Soldevilla, B.; Silva, J.; García, J.M.; García, V.; Peña, C.; Herrera, M.; Gómez, I.; Bonilla, F.; Domínguez, G. "Differential regulation of TP73 isoforms by 1α,25-dihydroxyvitamin D3 and survivin in human colon and breast carcinomas.". Genes Chromosomes Cancer. 49(12): 1135-1142. (2010). (PMID: 20842728).
Hägerstrand, D.; Lindh, M.B.; Peña, C.; Garcia-Echeverria, C.; Nistér, M.; Hofmann, F.; Ostman, A. "PI3K/PTEN/Akt pathway status affects the sensitivity of high-grade glioma cell cultures to the insulin-like growth factor-1 receptor inhibitor NVP-AEW541.". Neuro Oncol. 12(9): 967-975. (2010). (PMID: 20378689).
Saito, R.A.; Micke, P.; Paulsson, J.; Augsten, M.; Peña, C.; Jönsson, P.; Botling, J.; Edlund, K.; Johansson, L.; Carlsson, P.; Jirström, K.; Miyazono, K.; Ostman, A. "Forkhead box F1 regulates tumor-promoting properties of cancer-associated fibroblasts in lung cancer.". Cancer Res. 70(7): 2644-2654. (2010). (PMID: 20233876).
Augsten, M.; Hägglöf, C.; Peña, C.; Ostman, A. "A digest on the role of the tumor microenvironment in gastrointestinal cancers.". Cancer Microenviron. 3(1): 167-176. (2010). (PMID: 21209782).
Garcia, V.; Garcia, J.M.; Silva, J.; Martin, P.; Peña, C.; Dominguez, G.; Diaz, R.; Herrera, M.; Maximiano, C.; Sabin, P.; Rueda, A.; Cruz, M.A.; Rodriguez, J.; Canales, M.A.; Bonilla, F.; Provencio, M. "Extracellular tumor-related mRNA in plasma of lymphoma patients and survival implications.". PLoS One. 4(12): e8173. (2009). (PMID: 20016842).
Peña, C.; García, J.M.; Larriba, M.J.; Barderas, R.; Gómez, I.; Herrera, M.; García, V.; Silva, J.; Domínguez, G.; Rodríguez, R.; Cuevas, J.; de Herreros, A.G.; Casal, J.I.; Muñoz, A.; Bonilla, F. "SNAI1 expression in colon cancer related with CDH1 and VDR downregulation in normal adjacent tissue.". Oncogene. 28(49): 4375-4385. (2009). (PMID: 19802011).
Herrera, M.; Dominguez, G.; Garcia, J.M.; Peña, C.; Jimenez, C.; Silva, J.; Garcia, V.; Gomez, I.; Diaz, R.; Martin, P.; Bonilla, F. "Differences in repair of DNA cross-links between lymphocytes and epithelial tumor cells from colon cancer patients measured in vitro with the comet assay.". Clin Cancer Res. 15(17): 5466-5472. (2009). (PMID: 19690199).
Alvarez-Díaz, S.; Valle, N.; García, J.M.; Peña, C.; Freije, J.M.; Quesada, V.; Astudillo, A.; Bonilla, F.; López-Otín, C.; Muñoz, A. "Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells.". J. Clin. Invest.. 119(8): 2343-2358. (2009). (PMID: 19662683).
Lorenzo, Y.; Provencio, M.; Lombardía, L.; Díaz, R.; Silva, J.; Herrera, M.; García, J.M.; Peña, C.; García, V.; Romero, J.; Domínguez, G.; Bonilla, F. "Differential genetic and functional markers of second neoplasias in Hodgkin's disease patients.". Clin Cancer Res. 15(15): 4823-4828. (2009). (PMID: 19622580).
García, J.M.; García, V.; Peña, C.; Domínguez, G.; Silva, J.; Diaz, R.; Espinosa, P.; Citores, M.J.; Collado, M.; Bonilla, F. "Extracellular plasma RNA from colon cancer patients is confined in a vesicle-like structure and is mRNA-enriched.". RNA. 14(7): 1424-1432. (2008). (PMID: 18456845).
García, V.; García, J.M.; Peña, C.; Silva, J.; Domínguez, G.; Lorenzo, Y.; Diaz, R.; Espinosa, P.; de Sola, J.G.; Cantos, B.; Bonilla, F. "Free circulating mRNA in plasma from breast cancer patients and clinical outcome.". Cancer Lett. 263(2): 312-320. (2008). (PMID: 18280643).
Beltran, M.; Puig, I.; Peña, C.; García, J.M.; Alvarez, A.B.; Peña, R.; Bonilla, F.; de Herreros, A.G. "A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition.". Genes Dev. 22(6): 756-769. (2008). (PMID: 18347095).
Silva, J.; García, V.; García, J.M.; Peña, C.; Domínguez, G.; Díaz, R.; Lorenzo, Y.; Hurtado, A.; Sánchez, A.; Bonilla, F. "Circulating Bmi-1 mRNA as a possible prognostic factor for advanced breast cancer patients.". Breast Cancer Res. 9(4): R55. (2007). (PMID: 17711569).
García, J.M.; Peña, C.; García, V.; Domínguez, G.; Muñoz, C.; Silva, J.; Millán, I.; Diaz, R.; Lorenzo, Y.; Rodriguez, R.; Bonilla, F. "Prognostic value of LISCH7 mRNA in plasma and tumor of colon cancer patients.". Clin Cancer Res. 13(21): 6351-6358. (2007). (PMID: 17975147).
Silva, J.; García, J.M.; Peña, C.; García, V.; Domínguez, G.; Suárez, D.; Camacho, F.I.; Espinosa, R.; Provencio, M.; España, P.; Bonilla, F. "Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas.". Clin Cancer Res. 12(23): 6929-6936. (2006). (PMID: 17145810).
Domínguez, G.; Peña, C.; Silva, J.; García, J.M.; García, V.; Rodríguez, R.; Cantos, B.; Citores, M.J.; España, P.; Bonilla, F. "The presence of an intronic deletion in p73 and high levels of ZEB1 alter the TAp73/DeltaTAp73 ratio in colorectal carcinomas.". J Pathol. 210(4): 390-397. (2006). (PMID: 17029218).
Peña, C.; García, J.M.; García, V.; Silva, J.; Domínguez, G.; Rodríguez, R.; Maximiano, C.; García de Herreros, A.; Muñoz, A.; Bonilla, F. "The expression levels of the transcriptional regulators p300 and CtBP modulate the correlations between SNAIL, ZEB1, E-cadherin and vitamin D receptor in human colon carcinomas.". Int. J. Cancer. 119(9): 2098-2104. (2006). (PMID: 16804902).
Garcia, J.M.; Garcia, V.; Silva, J.; Peña, C.; Dominguez, G.; Sanchez, A.; Sanfrutos, L.; Provencio, M.; Millan, I.; Chaparro, D.; España, P.; Bonilla, F. "Extracellular tumor DNA in plasma and overall survival in breast cancer patients.". Genes Chromosomes Cancer. 45(7): 692-701. (2006). (PMID: 16607614).
Garcia, V.; García, J.M.; Peña, C.; Silva, J.; Domínguez, G.; Hurtado, A.; Alonso, I.; Rodriguez, R.; Provencio, M.; Bonilla, F. "Thymidylate synthase messenger RNA expression in plasma from patients with colon cancer: prognostic potential.". Clin Cancer Res. 12(7 Pt 1): 2095-2100. (2006). (PMID: 16609021).
Silva, J.; Silva, J.M.; Barradas, M.; García, J.M.; Domínguez, G.; García, V.; Peña, C.; Gallego, I.; Espinosa, R.; Serrano, M.; Bonilla, F. "Analysis of the candidate tumor suppressor Ris-1 in primary human breast carcinomas.". Mutat Res. 594(1-2): 78-85. (2006). (PMID: 16280139).
Domínguez, G.; García, J.M.; Peña, C.; Silva, J.; García, V.; Martínez, L.; Maximiano, C.; Gómez, M.E.; Rivera, J.A.; García-Andrade, C.; Bonilla, F. "DeltaTAp73 upregulation correlates with poor prognosis in human tumors: putative in vivo network involving p73 isoforms, p53, and E2F-1.". J Clin Oncol. 24(5): 805-815. (2006). (PMID: 16380414).
Peña, C.; García, J.M.; Silva, J.; García, V.; Rodríguez, R.; Alonso, I.; Millán, I.; Salas, C.; de Herreros, A.G.; Muñoz, A.; Bonilla, F. "E-cadherin and vitamin D receptor regulation by SNAIL and ZEB1 in colon cancer: clinicopathological correlations.". Hum Mol Genet. 14(22): 3361-3370. (2005). (PMID: 16203744).
Garcia, V.; García, J.M.; Peña, C.; Silva, J.; Domínguez, G.; Rodríguez, R.; Maximiano, C.; Espinosa, R.; España, P.; Bonilla, F. "The GADD45, ZBRK1 and BRCA1 pathway: quantitative analysis of mRNA expression in colon carcinomas.". J Pathol. 206(1): 92-99. (2005). (PMID: 15772983).
Garcia, V.; Silva, J.; Dominguez, G.; García, J.M.; Peña, C.; Rodriguez, R.; Provencio, M.; España, P.; Bonilla, F. "Overexpression of p16INK4a correlates with high expression of p73 in breast carcinomas.". Mutat Res. 554(1-2): 215-221. (2004). (PMID: 15450420).
García, J.M.; Silva, J.; Peña, C.; Garcia, V.; Rodríguez, R.; Cruz, M.A.; Cantos, B.; Provencio, M.; España, P.; Bonilla, F. "Promoter methylation of the PTEN gene is a common molecular change in breast cancer.". Genes Chromosomes Cancer. 41(2): 117-124. (2004). (PMID: 15287024).
Peña, C.; Garcia, J.M.; Dominguez, G.; Silva, J.; Garcia, V.; Carcereny, E.; Vargas, J.; Provencio, M.; España, P.; Bonilla, F. "Intronic deletion affecting a negative regulatory region of TP73 is related to breast and colorectal carcinomas.". Genes Chromosomes Cancer. 39(3): 257-262. (2004). (PMID: 14732927).
Garcia, V.; Domínguez, G.; García, J.M.; Silva, J.; Peña, C.; Silva, J.M.; Carcereny, E.; Menendez, J.; España, P.; Bonilla, F. "Altered expression of the ZBRK1 gene in human breast carcinomas.". J Pathol. 202(2): 224-232. (2004). (PMID: 14743505).
Instituto de Investigaciones Biomédicas "Alberto Sols"
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