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spacerTrabajos Publicados por Ana Guadaño Ferraz
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  1. Montero-Pedrazuela, A.; Grijota-Martínez, C.; Guadaño-Ferraz, A.; Bárez-López, S. "A Sensitive Radioimmunoassay for T3 and T4 Determinations in Plasma and Tissues.". Methods Mol Biol. 2876(): 37-59. (2025). (PMID: 39579307).
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  2. Guillén-Yunta, M.; Guadaño-Ferraz, A.; Valcárcel-Hernández, V. "Magnetic Resonance Imaging Techniques for Investigating the MCT8-Deficient Brain in Murine Disease Models.". Methods Mol Biol. 2876(): 175-186. (2025). (PMID: 39579316).
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  3. Guillén-Yunta, M.; García-Aldea, Á.; Valcárcel-Hernández, V.; Sanz-Bógalo, A.; Muñoz-Moreno, E.; Matheus, M.G.; Grijota-Martínez, C.; Montero-Pedrazuela, A.; Guadaño-Ferraz, A.; Bárez-López, S. "Defective thyroid hormone transport to the brain leads to astroglial alterations.". Neurobiol Dis. (): 106621. (2024). (PMID: 39097035).
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  4. Valcárcel-Hernández, V.; Vancamp, P.; Butruille, L.; Remaud, S.; Guadaño-Ferraz, A. "Combined deletion of Mct8 and Dio2 impairs SVZ neurogliogenesis and olfactory function in adult mice.". Neurobiol Dis. (): 106572. (2024). (PMID: 38901782).
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  5. Valcárcel-Hernández, V.; Mayerl, S.; Guadaño-Ferraz, A.; Remaud, S. "Thyroid hormone action in adult neurogliogenic niches: the known and unknown.". Front Endocrinol (Lausanne). 15(): 1347802. (2024). (PMID: 38516412).
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  6. García-Aldea, Á.; Guillén-Yunta, M.; Valcárcel-Hernández, V.; Montero-Pedrazuela, A.; Guadaño-Ferraz, A.; Bárez-López, S. "Insights on the role of thyroid hormone transport in neurosensory organs and implication for Allan-Herndon-Dudley syndrome.". Eur Thyroid J. (): . (2024). (PMID: 38417253).
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  7. Guillén-Yunta, M.; Valcárcel-Hernández, V.; García-Aldea, Á.; Soria, G.; García-Verdugo, J.M.; Montero-Pedrazuela, A.; Guadaño-Ferraz, A. "Neurovascular unit disruption and blood-brain barrier leakage in MCT8 deficiency.". Fluids Barriers CNS. 20(1): 79. (2023). (PMID: 37924081).
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  8. Wang, T.; Wang, Y.; Montero-Pedrazuela, A.; Prensa, L.; Guadaño-Ferraz, A.; Rausell, E. "Thyroid Hormone Transporters MCT8 and OATP1C1 Are Expressed in Projection Neurons and Interneurons of Basal Ganglia and Motor Thalamus in the Adult Human and Macaque Brains.". Int J Mol Sci. 24(11): . (2023). (PMID: 37298594).
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  9. Valcárcel Hernández, V.; Guillén Yunta, M.; Scanlan, T.; Bárez-López, S.; Guadaño-Ferraz, A. "Maternal administration of the CNS-selective sobetirome prodrug Sob-AM2 exerts thyromimetic effects in murine MCT8-deficient fetuses.". Thyroid. (): . (2023). (PMID: 36792926).
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  10. Wang, Y.; Wang, T.; Montero-Pedrazuela, A.; Guadaño-Ferraz, A.; Rausell, E. "Thyroid Hormone Transporters MCT8 and OATP1C1 Are Expressed in Pyramidal Neurons and Interneurons in the Adult Motor Cortex of Human and Macaque Brain.". Int J Mol Sci. 24(4): . (2023). (PMID: 36834621).
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  11. Grijota-Martínez, C.; Montero-Pedrazuela, A.; Hidalgo-Álvarez, J.; Bárez-López, S.; Guadaño-Ferraz, A. "Intracerebroventricular High Doses of 3,3',5-Triiodothyroacetic Acid at Juvenile Stages Improve Peripheral Hyperthyroidism and Mediate Thyromimetic Effects in Limited Brain Regions in a Mouse Model of Monocarboxylate Transporter 8 Deficiency.". Thyroid. (): . (2023). (PMID: 36565029).
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  12. Valcárcel-Hernández, V.; Guillén-Yunta, M.; Bueno-Arribas, M.; Montero-Pedrazuela, A.; Grijota-Martínez, C.; Markossian, S.; García-Aldea, Á.; Flamant, F.; Bárez-López, S.; Guadaño-Ferraz, A. "A CRISPR/Cas9-engineered avatar mouse model of monocarboxylate transporter 8 deficiency displays distinct neurological alterations.". Neurobiol Dis. (): 105896. (2022). (PMID: 36243247).
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  13. Valcárcel-Hernández, V.; López-Espíndola, D.; Guillén-Yunta, M.; García-Aldea, Á.; de Toledo-Soler, I.L.; Bárez-López, S.; Guadaño-Ferraz, A. "Deficient thyroid hormone transport to the brain leads to impairments in axonal caliber and oligodendroglial development.". Neurobiol Dis. (): 105567. (2021). (PMID: 34838669).
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  14. Escalona-Garrido, C.; Vázquez, P.; Mera, P.; Zagmutt, S.; García-Casarrubios, E.; Montero-Pedrazuela, A.; Rey-Stolle, F.; Guadaño-Ferraz, A.; Rupérez, F.J.; Serra, D.; Herrero, L.; Obregon, M.J.; Valverde, Á.M. "Moderate SIRT1 overexpression protects against inflammation of brown adipose tissue.". Mol Metab. (): 101097. (2020). (PMID: 33049408).
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  15. Grijota-Martínez, C.; Bárez-López, S.; Ausó, E.; Refetoff, S.; Frey, W.H.; Guadaño-Ferraz, A. "Intranasal delivery of Thyroid hormones in MCT8 deficiency.". PLoS ONE. 15(7): e0236113. (2020). (PMID: 32687511).
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  16. Grijota-Martínez, C.; Bárez-López, S.; Gómez-Andrés, D.; Guadaño-Ferraz, A. "MCT8 Deficiency: The Road to Therapies for a Rare Disease.". Front Neurosci. 14(): 380. (2020). (PMID: 32410949).
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  17. Bárez-López, S.; Grijota-Martínez, C.; Liao, X.H.; Refetoff, S.; Guadaño-Ferraz, A. "Intracerebroventricular administration of the thyroid hormone analog TRIAC increases its brain content in the absence of MCT8.". PLoS ONE. 14(12): e0226017. (2019). (PMID: 31809508).
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  18. Bárez-López, S.; Grijota-Martínez, C.; Ausó, E.; Fernández-de Frutos, M.; Montero-Pedrazuela, A.; Guadaño-Ferraz, A. "Adult mice lacking Mct8 and Dio2 proteins present alterations in peripheral thyroid hormone levels and severe brain and motor skill impairments.". Thyroid. (): . (2019). (PMID: 31359845).
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  19. López-Espíndola, D.; García-Aldea, Á.; Gómez de la Riva, I.; Rodríguez-García, A.M.; Salvatore, D.; Visser, T.J.; Bernal, J.; Guadaño-Ferraz, A. "Thyroid hormone availability in the human fetal brain: novel entry pathways and role of radial glia.". Brain Struct Funct. 224(6): 2103-2119. (2019). (PMID: 31165302).
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  20. Ordás, P.; Hernández-Ortego, P.; Vara, H.; Fernández-Peña, C.; Reimúndez, A.; Morenilla-Palao, C.; Guadaño-Ferraz, A.; Gomis, A.; Hoon, M.; Viana, F.; Señarís, R. "Expression of the cold thermoreceptor TRPM8 in rodent brain thermoregulatory circuits.". J. Comp. Neurol.. (): . (2019). (PMID: 30942489).
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  21. Bárez-López, S.; Hartley, M.D.; Grijota-Martínez, C.; Scanlan, T.; Guadaño-Ferraz, A. "Sobetirome and its amide prodrug Sob-AM2 exert thyromimetic actions in Mct8-deficient brain.". Thyroid. (): . (2018). (PMID: 29845892).
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  22. Bárez-López, S.; Obregon, M.J.; Bernal, J.; Guadaño-Ferraz, A. "Thyroid Hormone Economy in the Perinatal Mouse Brain: Implications for Cerebral Cortex Development.". Cereb. Cortex. 28(5): 1783-1793. (2018). (PMID: 28407057).
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  23. Bárez-López, S.; Montero-Pedrazuela, A.; Bosch-García, D.; Venero, C.; Guadaño-Ferraz, A. "Increased anxiety and fear memory in adult mice lacking type 2 deiodinase.". Psychoneuroendocrinology. 84(): 51-60. (2017). (PMID: 28654773).
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  24. Bárez-López, S.; Guadaño-Ferraz, A. "Thyroid Hormone Availability and Action during Brain Development in Rodents.". Front Cell Neurosci. 11(): 240. (2017). (PMID: 28855863).
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  25. España-Serrano, L.; Guerra Martín-Palanco, N.; Montero-Pedrazuela, A.; Pérez-Santamarina, E.; Vidal, R.; García-Consuegra, I.; Valdizán, E.M.; Pazos, A.; Palomo, T.; Jiménez-Arriero, M.Á.; Guadaño-Ferraz, A.; Hoenicka, J. "The Addiction-Related Protein ANKK1 is Differentially Expressed During the Cell Cycle in Neural Precursors.". Cereb. Cortex. 27(5): 2809-2819. (2017). (PMID: 27166167).
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  26. Iwayama, H.; Liao, X.H.; Braun, L.; Bárez-López, S.; Kaspar, B.; Weiss, R.; Dumitrescu, A.M.; Guadaño-Ferraz, A.; Refetoff, S. "Adeno associated virus 9-based gene therapy delivers a functional monocarboxylate transporter 8 (MCT8) which improves thyroid hormone availability to brain of Mct8 deficient mice.". Thyroid. (): . (2016). (PMID: 27432638).
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  27. Bárez-López, S.; Obregon, M.J.; Martínez-de-Mena, R.; Bernal, J.; Guadaño-Ferraz, A.; Morte, B. "Effect of Triiodothyroacetic Acid Treatment in Mct8 Deficiency: A Word of Caution.". Thyroid. 26(5): 618-626. (2016). (PMID: 26701289).
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  28. Bernal, J.; Guadaño-Ferraz, A.; Morte, B. "Thyroid hormone transporters-functions and clinical implications.". Nat Rev Endocrinol. 11(12): 690. (2015). (PMID: 26485690).
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  29. Bernal, J.; Guadaño-Ferraz, A.; Morte, B. "Thyroid hormone transporters--functions and clinical implications.". Nat Rev Endocrinol. 11(9): 506. (2015). (PMID: 26149615).
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  30. Bernal, J.; Guadaño-Ferraz, A.; Morte, B. "Thyroid hormone transporters--functions and clinical implications.". Nat Rev Endocrinol. 11(7): 406-417. (2015). (PMID: 25942657).
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  31. López-Espíndola, D.; Morales-Bastos, C.; Grijota-Martínez, C.; Liao, X.H.; Lev, D.; Sugo, E.; Verge, C.F.; Refetoff, S.; Bernal, J.; Guadaño-Ferraz, A. "Mutations of the thyroid hormone transporter MCT8 cause prenatal brain damage and persistent hypomyelination.". J. Clin. Endocrinol. Metab.. 99(12): E2799-804. (2014). (PMID: 25222753).
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  32. Bárez-López, S.; Bosch-García, D.; Gómez-Andrés, D.; Pulido-Valdeolivas, I.; Montero-Pedrazuela, A.; Obregon, M.J.; Guadaño-Ferraz, A. "Abnormal motor phenotype at adult stages in mice lacking type 2 deiodinase.". PLoS ONE. 9(8): e103857. (2014). (PMID: 25083788).
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  33. Montero-Pedrazuela, A.; Fernández-Lamo, I.; Alieva, M.; Pereda-Pérez, I.; Venero, C.; Guadaño-Ferraz, A. "Adult-onset hypothyroidism enhances fear memory and upregulates mineralocorticoid and glucocorticoid receptors in the amygdala.". PLoS ONE. 6(10): e26582. (2011). (PMID: 22039511).
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  34. Fernández-Lamo, I.; Montero-Pedrazuela, A.; Delgado-García, J.M.; Guadaño-Ferraz, A.; Gruart, A. "Effects of thyroid hormone replacement on associative learning and hippocampal synaptic plasticity in adult hypothyroid rats.". Eur. J. Neurosci.. 30(4): 679-692. (2009). (PMID: 19686470).
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  35. Montero-Pedrazuela, A.; Venero, C.; Lavado-Autric, R.; Fernández-Lamo, I.; García-Verdugo, J.M.; Bernal, J.; Guadaño-Ferraz, A. "Modulation of adult hippocampal neurogenesis by thyroid hormones: implications in depressive-like behavior.". Mol Psychiatry. 11(4): 361-371. (2006). (PMID: 16446739).
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  36. Barrantes, I.d.e.l. .B.; Montero-Pedrazuela, A.; Guadaño-Ferraz, A.; Obregon, M.J.; Martinez de Mena, R.; Gailus-Durner, V.; Fuchs, H.; Franz, T.J.; Kalaydjiev, S.; Klempt, M.; Hölter, S.; Rathkolb, B.; Reinhard, C.; Morreale de Escobar, G.; Bernal, J.; Busch, D.H.; Wurst, W.; Wolf, E.; Schulz, H.; Shtrom, S.; Greiner, E.; Hrabé de Angelis, M.; Westphal, H.; Niehrs, C. "Generation and characterization of dickkopf3 mutant mice.". Mol. Cell. Biol.. 26(6): 2317-2326. (2006). (PMID: 16508007).
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  37. Guadaño-Ferraz, A.; Viñuela, A.; Oeding, G.; Bernal, J.; Rausell, E. "RC3/neurogranin is expressed in pyramidal neurons of motor and somatosensory cortex in normal and denervated monkeys.". J. Comp. Neurol.. 493(4): 554-570. (2005). (PMID: 16304627).
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  38. Venero, C.; Guadaño-Ferraz, A.; Herrero, A.I.; Nordström, K.; Manzano, J.; de Escobar, G.M.; Bernal, J.; Vennström, B. "Anxiety, memory impairment, and locomotor dysfunction caused by a mutant thyroid hormone receptor alpha1 can be ameliorated by T3 treatment.". Genes Dev. 19(18): 2152-2163. (2005). (PMID: 16131613).
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  39. Martin, G.; Guadaño-Ferraz, A.; Morte, B.; Ahmed, S.; Koob, G.F.; De Lecea, L.; Siggins, G.R. "Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens.". J. Pharmacol. Exp. Ther.. 311(1): 265-273. (2004). (PMID: 15263066).
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  40. Quignodon, L.; Legrand, C.; Allioli, N.; Guadaño-Ferraz, A.; Bernal, J.; Samarut, J.; Flamant, F. "Thyroid hormone signaling is highly heterogeneous during pre- and postnatal brain development.". J. Mol. Endocrinol.. 33(2): 467-476. (2004). (PMID: 15525602).
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  41. Bernal, J.; Guadaño-Ferraz, A.; Morte, B. "Perspectives in the study of thyroid hormone action on brain development and function.". Thyroid. 13(11): 1005-1012. (2003). (PMID: 14651784).
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  42. Montero-Pedrazuela, A.; Bernal, J.; Guadaño-Ferraz, A. "Divergent expression of type 2 deiodinase and the putative thyroxine-binding protein p29, in rat brain, suggests that they are functionally unrelated proteins.". Endocrinology. 144(3): 1045-1052. (2003). (PMID: 12586781).
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  43. Guadaño-Ferraz, A.; Benavides-Piccione, R.; Venero, C.; Lancha, C.; Vennström, B.; Sandi, C.; DeFelipe, J.; Bernal, J. "Lack of thyroid hormone receptor alpha1 is associated with selective alterations in behavior and hippocampal circuits.". Mol. Psychiatry. 8(1): 30-38. (2003). (PMID: 12556906).
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  44. Bernal, J.; Guadaño-Ferraz, A. "Analysis of thyroid hormone-dependent genes in the brain by in situ hybridization.". Methods Mol. Biol.. 202(): 71-90. (2002). (PMID: 12094608).
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  45. Escámez, M.J.; Guadaño-Ferraz, A.; Cuadrado, A.; Bernal, J. "Type 3 iodothyronine deiodinase is selectively expressed in areas related to sexual differentiation in the newborn rat brain.". Endocrinology. 140(11): 5443-5446. (1999). (PMID: 10537178).
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  46. Calbet, M.; Guadaño-Ferraz, A.; Spier, A.D.; Maj, M.; Sutcliffe, J.G.; Przewłocki, R.; de Lecea, L. "Cortistatin and somatostatin mRNAs are differentially regulated in response to kainate.". Brain Res. Mol. Brain Res.. 72(1): 55-64. (1999). (PMID: 10521599).
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  47. Guadaño-Ferraz, A.; Escámez, M.J.; Rausell, E.; Bernal, J. "Expression of type 2 iodothyronine deiodinase in hypothyroid rat brain indicates an important role of thyroid hormone in the development of specific primary sensory systems.". J. Neurosci.. 19(9): 3430-3439. (1999). (PMID: 10212303).
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  48. Guadaño-Ferraz, A.; Escámez, M.J.; Morte, B.; Vargiu, P.; Bernal, J. "Transcriptional induction of RC3/neurogranin by thyroid hormone: differential neuronal sensitivity is not correlated with thyroid hormone receptor distribution in the brain.". Brain Res. Mol. Brain Res.. 49(1-2): 37-44. (1997). (PMID: 9387861).
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  49. Guadaño-Ferraz, A.; Obregón, M.J.; St Germain, D.L.; Bernal, J. "The type 2 iodothyronine deiodinase is expressed primarily in glial cells in the neonatal rat brain.". Proc. Natl. Acad. Sci. U.S.A.. 94(19): 10391-10396. (1997). (PMID: 9294221).
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  50. Iniguez, M.A.; De Lecea, L.; Guadano-Ferraz, A.; Morte, B.; Gerendasy, D.; Sutcliffe, J.G.; Bernal, J. "Cell-specific effects of thyroid hormone on RC3/neurogranin expression in rat brain.". Endocrinology. 137(3): 1032-1041. (1996). (PMID: 8603571).
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  51. Velaz-Faircloth, M.; Guadaño-Ferraz, A.; Henzi, V.A.; Fremeau, R.T. "Mammalian brain-specific L-proline transporter. Neuronal localization of mRNA and enrichment of transporter protein in synaptic plasma membranes.". J. Biol. Chem.. 270(26): 15755-15761. (1995). (PMID: 7797577).
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  52. Berbel, P.; Guadaño-Ferraz, A.; Angulo, A.; Ramón Cerezo, J. "Role of thyroid hormones in the maturation of interhemispheric connections in rats.". Behav. Brain Res.. 64(1-2): 9-14. (1994). (PMID: 7840896).
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  53. Guadaño Ferraz, A.; Escobar del Rey, F.; Morreale de Escobar, G.; Innocenti, G.M.; Berbel, P. "The development of the anterior commissure in normal and hypothyroid rats.". Brain Res. Dev. Brain Res.. 81(2): 293-308. (1994). (PMID: 7813049).
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  54. Shafqat, S.; Velaz-Faircloth, M.; Guadaño-Ferraz, A.; Fremeau, R.T. "Molecular characterization of neurotransmitter transporters.". Mol. Endocrinol.. 7(12): 1517-1529. (1993). (PMID: 7908408).
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  55. Berbel, P.; Guadaño-Ferraz, A.; Martínez, M.; Quiles, J.A.; Balboa, R.; Innocenti, G.M. "Organization of auditory callosal connections in hypothyroid adult rats.". Eur. J. Neurosci.. 5(11): 1465-1478. (1993). (PMID: 7506971).
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  56. Shafqat, S.; Tamarappoo, B.K.; Kilberg, M.S.; Puranam, R.S.; McNamara, J.O.; Guadaño-Ferraz, A.; Fremeau, R.T. "Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters.". J. Biol. Chem.. 268(21): 15351-15355. (1993). (PMID: 8340364).
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  57. Guadano-Ferraz, A.; Riederer, B.M.; Innocenti, G.M. "Developmental changes in the heavy subunit of neurofilaments in the corpus callosum of the cat.". Brain Res. Dev. Brain Res.. 56(2): 244-256. (1990). (PMID: 2124524).
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  58. Riederer, B.M.; Guadano-Ferraz, A.; Innocenti, G.M. "Difference in distribution of microtubule-associated proteins 5a and 5b during the development of cerebral cortex and corpus callosum in cats: dependence on phosphorylation.". Brain Res. Dev. Brain Res.. 56(2): 235-243. (1990). (PMID: 2261685).
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