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Cancer is one of the main caused of death in EU and other developed countries. Current techniques can only diagnose and treat the late symptoms of cancer, what it is getting this disease in a chronic process. Nowadays, there are more then 30 angiogenic inhibitors in clinical trials, nevertheless there are not appropriate procedures to visualize and monitor the effectiveness of these therapies. Magnetic Resonance Imaging (MRI), Spectroscopy (MRS) and Spectroscopic Imaging (MRSI) technologies provide a great potential to solve this situation in a near future. These methodologies make possible the in vivo study, among other parameters, of vascularization, oxygenation level, pH and tumoral metabolism in a non invasive way, allowing direct monitoring of different antitumoral therapies.
In our research group the main objective is focused in the development of new MR methodologies that afford the possibility of in vivo characterization of the tumoral microenvironment and visualization of neovascularization and tumoral metabolism. That will drive us to a better understanding of the physiological and biochemical bases of connections between these parameters.