1 Jul | 2025 Loss of cadherin 17 downregulates LGR5 expression, stem cell properties and drug resistance in metastatic colorectal cancer cells. Bartolomé, RA, Pintado-Berninches, L , Robles, J, Calvo-López, T, Boukich, I, Otero-Núñez, P, Gonzalez-Sancho, JM , Casal, JI. Cell Death Dis - 16 (1) : 475 (PMID: 40595509) (doi:10.1038/s41419-025-07811-w)
29 Apr | 2024 Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids. Bustamante-Madrid, P , Barbáchano, A , Albandea-Rodríguez, D , Rodríguez-Cobos, J , Rodríguez-Salas, N, Prieto, I, Burgos, A, Martínez de Villarreal, J, Real, FX, González-Sancho, JM , Larriba, MJ , Lafarga, M, Muñoz, A , Fernández-Barral, A . Cell Death Dis - 15 (4) : 301 (PMID: 38684650) (doi:10.1038/s41419-024-06680-z)
12 Sep | 2023 From molecular basis to clinical insights: a challenging future for the vitamin D endocrine system in colorectal cancer. Pereira, F , Fernández-Barral, A , Larriba, MJ , Barbáchano, A , González-Sancho, JM . FEBS J (PMID: 37699548) (doi:10.1111/febs.16955)
24 Aug | 2023 Clinico-Pathological Features, Outcomes and Impacts of COVID-19 Pandemic on Patients with Early-Onset Colorectal Cancer: A Single-Institution Experience. Martinez-Perez, D, Viñal, D, Peña-Lopez, J, Jimenez-Bou, D, Ruiz-Gutierrez, I, Martinez-Recio, S, Alameda-Guijarro, M, Rueda-Lara, A, Martin-Montalvo, G, Ghanem, I, Custodio, AB, Trilla-Fuertes, L, Gamez-Pozo, A, Barbachano, A , Rodriguez-Cobos, J , Bustamante-Madrid, P , Fernandez-Barral, A , Burgos, A, Prieto-Nieto, MI, Pastrian, LG, González-Sancho, JM , Muñoz, A , Feliu, J, Rodríguez-Salas, N. Cancers (Basel) - 15 (17) (PMID: 37686518) (doi:10.3390/cancers15174242)
19 Nov | 2020 Wnt and Vitamin D at the Crossroads in Solid Cancer. González-Sancho, JM , Larriba, MJ , Muñoz, A . Cancers (Basel) - 12 (11) (PMID: 33227961) (doi:10.3390/cancers12113434)
30 May | 2019 Vitamin D and Wnt3A have additive and partially overlapping modulatory effects on gene expression and phenotype in human colon fibroblasts. Ferrer-Mayorga, G , Niell, N , Cantero, R, González-Sancho, JM , Del Peso, L , Muñoz, A , Larriba, MJ . Sci Rep - 9 (1) : 8085 (PMID: 31147591) (doi:10.1038/s41598-019-44574-9)
29 Jun | 2018 Aryl Hydrocarbon Receptor Promotes Liver Polyploidization and Inhibits PI3K, ERK, and Wnt/β-Catenin Signaling. Moreno-Marín, N, Merino, JM, Alvarez-Barrientos, A, Patel, DP, Takahashi, S, González-Sancho, JM , Gandolfo, P, Rios, RM, Muñoz, A , Gonzalez, FJ, Fernández-Salguero, PM. iScience - 4 : 44-63 (PMID: 30240752) (doi:10.1016/j.isci.2018.05.006)
15 Feb | 2018 The human PKP2/plakophilin-2 gene is induced by Wnt/β-catenin in normal and colon cancer-associated fibroblasts. Niell, N , Larriba, MJ , Ferrer-Mayorga, G , Sánchez-Pérez, I , Cantero, R, Real, FX, Del Peso, L , Muñoz, A , González-Sancho, JM . Int. J. Cancer - 142 (4) : 792-804 (PMID: 29044515) (doi:10.1002/ijc.31104)
9 Jun | 2016 SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150. Barbáchano, A , Fernández-Barral, A , Pereira, F, Segura, MF, Ordóñez-Morán, P , Carrillo-de Santa Pau, E, González-Sancho, JM , Hanniford, D, Martínez, N, Costales-Carrera, A, Real, FX, Pálmer, HG , Rojas, JM, Hernando, E, Muñoz, A . Oncogene - 35 (23) : 2991-3003 (PMID: 26455323) (doi:10.1038/onc.2015.366)
20 Mar | 2015 Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer. Aguilera, Ó, González-Sancho, JM , Zazo, S, Rincón, R, Fernández, AF, Tapia, O, Canals, F, Morte, B , Calvanese, V, Orgaz, JL , Niell, N , Aguilar, S, Freije, JM, Graña, O, Pisano, DG, Borrero, A, Martínez-Useros, J, Jiménez, B , Fraga, MF, García-Foncillas, J, López-Otín, C, Lafarga, M, Rojo, F, Muñoz, A . Oncotarget - 6 (8) : 5903-5917 (PMID: 25788273) (doi:10.18632/oncotarget.3464)
1 Mar | 2015 WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes. Rada, P , Rojo, AI , Offergeld, A, Feng, GJ, Velasco-Martín, JP, González-Sancho, JM , Valverde, ÁM , Dale, T, Regadera, J, Cuadrado, A . Antioxid. Redox Signal. - 22 (7) : 555-571 (PMID: 25336178) (doi:10.1089/ars.2014.6040)
18 Feb | 2014 Interaction of vitamin D with membrane-based signaling pathways. Larriba, MJ , González-Sancho, JM , Bonilla, F, Muñoz, A . Front Physiol - 5 : 60 (PMID: 24600406) (doi:10.3389/fphys.2014.00060)
21 Oct | 2013 Vitamin D Is a Multilevel Repressor of Wnt/b-Catenin Signaling in Cancer Cells. Larriba, MJ , González-Sancho, JM , Barbáchano, A , Niell, N , Ferrer-Mayorga, G , Muñoz, A . Cancers (Basel) - 5 (4) : 1242-1260 (PMID: 24202444) (doi:10.3390/cancers5041242)
9 Mar | 2013 The use of an active learning approach to teach metabolism to students of nutrition and dietetics. González-Sancho, JM , Sánchez-Pacheco, A , Lasa, M , Molina, S, Vara, F , del Peso, L . Biochem Mol Biol Educ - 41 (3) : 131-138 (PMID: 23483652) (doi:10.1002/bmb.20684)
1 Dec | 2010 Differential regulation of TP73 isoforms by 1α,25-dihydroxyvitamin D3 and survivin in human colon and breast carcinomas. Díaz, R, González-Sancho, JM , Soldevilla, B, Silva, J, García, JM, García, V, Peña, C , Herrera, M, Gómez, I, Bonilla, F, Domínguez, G . Genes Chromosomes Cancer - 49 (12) : 1135-1142 (PMID: 20842728) (doi:10.1002/gcc.20821)
30 Jun | 2010 Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer. Lara, E, Calvanese, V, Huidobro, C, Fernández, AF, Moncada-Pazos, A, Obaya, AJ, Aguilera, O , González-Sancho, JM , Sánchez, L, Astudillo, A, Muñoz, A , López-Otín, C, Esteller, M, Fraga, MF. Mol. Cancer - 9 : 170 (PMID: 20591152) (doi:10.1186/1476-4598-9-170)
5 Mar | 2010 The EWS/FLI1 oncogenic protein inhibits expression of the Wnt inhibitor DICKKOPF-1 gene and antagonizes beta-catenin/TCF-mediated transcription. Navarro, D , Agra, N , Pestaña, A , Alonso, J , González-Sancho, JM . Carcinogenesis - 31 (3) : 394-401 (PMID: 20019092) (doi:10.1093/carcin/bgp317)
16 Dec | 2008 Vitamin D and Wnt/beta-catenin pathway in colon cancer: role and regulation of DICKKOPF genes. Pendás-Franco, N , Aguilera, O , Pereira, F , González-Sancho, JM , Muñoz, A . Anticancer Res. - 28 (5A) : 2613-2623 (PMID: 19035286)
24 Jul | 2008 DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3. Pendás-Franco, N , García, JM , Peña, C , Valle, N , Pálmer, HG , Heinäniemi, M, Carlberg, C, Jiménez, B , Bonilla, F, Muñoz, A , González-Sancho, JM . Oncogene - 27 (32) : 4467-4477 (PMID: 18408752) (doi:10.1038/onc.2008.88)
28 Sep | 2007 The Wnt antagonist DICKKOPF-1 gene is induced by 1alpha,25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells. Aguilera, O , Peña, C , García, JM, Larriba, MJ , Ordóñez-Morán, P , Navarro, D , Barbáchano, A , López de Silanes, I, Ballestar, E, Fraga, MF, Esteller, M, Gamallo, C , Bonilla, F, González-Sancho, JM , Muñoz, A . Carcinogenesis - 28 (9) : 1877-1884 (PMID: 17449905) (doi:10.1093/carcin/bgm094)
30 Mar | 2007 The inhibition of Wnt/beta-catenin signalling by 1alpha,25-dihydroxyvitamin D3 is abrogated by Snail1 in human colon cancer cells. Larriba, MJ , Valle, N , Pálmer, HG , Ordóñez-Morán, P , Alvarez-Díaz, S , Becker, KF, Gamallo, C , de Herreros, AG, González-Sancho, JM , Muñoz, A . Endocr. Relat. Cancer - 14 (1) : 141-151 (PMID: 17395983) (doi:10.1677/ERC-06-0028)
15 Mar | 2007 Vitamin D regulates the phenotype of human breast cancer cells. Pendás-Franco, N , González-Sancho, JM , Suárez, Y , Aguilera, O , Steinmeyer, A, Gamallo, C , Berciano, MT, Lafarga, M, Muñoz, A . Differentiation - 75 (3) : 193-207 (PMID: 17288543) (doi:10.1111/j.1432-0436.2006.00131.x)
22 Aug | 2006 Effects of 1alpha,25-dihydroxyvitamin D3 in human colon cancer cells. González-Sancho, JM , Larriba, MJ , Ordóñez-Morán, P , Pálmer, HG , Muñoz, A . Anticancer Res. - 26 (4A) : 2669-2681 (PMID: 16886677)
6 Jul | 2006 Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer. Aguilera, O , Fraga, MF, Ballestar, E, Paz, MF, Herranz, M, Espada, J , García, JM , Muñoz, A , Esteller, M, González-Sancho, JM . Oncogene - 25 (29) : 4116-4121 (PMID: 16491118) (doi:10.1038/sj.onc.1209439)
1 Sep | 2005 Vitamin D and cancer: an update of in vitro and in vivo data. Ordonez-Moran, P , Larriba, MJ , Pendas-Franco, N , Aguilera, O , Gonzalez-Sancho, JM , Munoz, A . Front. Biosci. - 10 : 2723-2749 (PMID: 15970529)
3 Feb | 2005 The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer. González-Sancho, JM , Aguilera, O , García, JM, Pendás-Franco, N , Peña, C , Cal, S, García de Herreros, A, Bonilla, F, Muñoz, A . Oncogene - 24 (6) : 1098-1103 (PMID: 15592505) (doi:10.1038/sj.onc.1208303)
21 Jun | 2004 Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. González-Sancho, JM , Brennan, KR, Castelo-Soccio, LA, Brown, AM. Mol. Cell. Biol. - 24 (11) : 4757-4768 (PMID: 15143170) (doi:10.1128/MCB.24.11.4757-4768.2004)
31 Mar | 2003 Thyroid hormone receptors/THR genes in human cancer. González-Sancho, JM , García, V, Bonilla, F, Muñoz, A . Cancer Lett. - 192 (2) : 121-132 (PMID: 12668276)
1 Oct | 2002 Glucocorticoid receptor antagonism of AP-1 activity by inhibition of MAPK family. Caelles, C , Bruna, A, Morales, M, González-Sancho, JM , González, MV , Jiménez, B , Muñoz, A . Ernst Schering Res. Found. Workshop (PMID: 12355714)
20 Jun | 2002 Expression of thyroid hormone receptor/erbA genes is altered in human breast cancer. Silva, JM, Domínguez, G , González-Sancho, JM , García, JM, Silva, J, García-Andrade, C, Navarro, A, Muñoz, A , Bonilla, F. Oncogene - 21 (27) : 4307-4316 (PMID: 12082618) (doi:10.1038/sj.onc.1205534)
1 May | 2002 Inhibition of proliferation and expression of T1 and cyclin D1 genes by thyroid hormone in mammary epithelial cells. González-Sancho, JM , Figueroa, A , López-Barahona, M, López, E, Beug, H, Muñoz, A . Mol. Carcinog. - 34 (1) : 25-34 (PMID: 12112320) (doi:10.1002/mc.10046)
23 Jul | 2001 Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. Pálmer, HG , González-Sancho, JM , Espada, J , Berciano, MT, Puig, I, Baulida, J, Quintanilla, M , Cano, A , de Herreros, AG, Lafarga, M, Muñoz, A . J Cell Biol - 154 (2) : 369-387 (PMID: 11470825) (doi:10.1083/jcb.200102028)
4 Sep | 2000 Glucocorticoids antagonize AP-1 by inhibiting the Activation/phosphorylation of JNK without affecting its subcellular distribution. González, MV , Jiménez, B , Berciano, MT, González-Sancho, JM , Caelles, C , Lafarga, M, Muñoz, A . J. Cell Biol. - 150 (5) : 1199-1208 (PMID: 10974006)
15 Oct | 1999 Retinoic acid and 1,25-dihydroxyvitamin D3 inhibit tenascin-C expression in rat glioma C6 cells. Alvarez-Dolado, M , González-Sancho, JM , Navarro-Yubero, C , García-Fernández, LF , Muñoz, A . J. Neurosci. Res. - 58 (2) : 293-300 (PMID: 10502285)
8 Oct | 1999 Hormone-activated nuclear receptors inhibit the stimulation of the JNK and ERK signalling pathways in endothelial cells. González, MV , González-Sancho, JM , Caelles, C , Munoz, A , Jiménez, B . FEBS Lett. - 459 (2) : 272-276 (PMID: 10518034)
1 Feb | 1999 Inhibition of tenascin-C expression in mammary epithelial cells by thyroid hormone. González-Sancho, JM , Alvarez-Dolado, M , Caelles, C , Muñoz, A . Mol. Carcinog. - 24 (2) : 99-9107 (PMID: 10078937)
8 May | 1998 Developmental expression of the tenascin-C is altered by hypothyroidism in the rat brain. Alvarez-Dolado, M , González-Sancho, JM , Bernal, J , Muñoz, A . Neuroscience - 84 (1) : 309-322 (PMID: 9580330)
17 Apr | 1998 1,25-Dihydroxyvitamin D3 inhibits tenascin-C expression in mammary epithelial cells. González-Sancho, JM , Alvarez-Dolado, M , Muñoz, A . FEBS Lett. - 426 (2) : 225-228 (PMID: 9599013)
15 Dec | 1997 Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway. Caelles, C , González-Sancho, JM , Muñoz, A . Genes Dev. - 11 (24) : 3351-3364 (PMID: 9407028)
15 Mar | 1995 Thyroid hormone regulates stromelysin expression, protease secretion and the morphogenetic potential of normal polarized mammary epithelial cells. López-Barahona, M, Fialka, I, González-Sancho, JM , Asunción, M , González, M, Iglesias, T , Bernal, J , Beug, H, Muñoz, A . EMBO J. - 14 (6) : 1145-1155 (PMID: 7720705)