29 May | 2024 A Novel Missense Variant in the NKX2-1 Homeodomain Prevents Transcriptional Rescue by TAZ. Villafuerte, B, Carrasco-López, C , Herranz, A, Garzón, L, Simón, R, Natera-de-Benito, D, Alikhani, P, Tenorio, J, García-Santiago, F, Solis, M, Del-Pozo, Á, Lapunzina, P, Ortigoza-Escobar, JD, Santisteban, P , Moreno, JC. Thyroid (PMID: 38757609) (doi:10.1089/thy.2023.0593)
3 May | 2024 Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer. Haderk, F, Chou, YT, Cech, L, Fernández-Méndez, C , Yu, J, Olivas, V, Meraz, IM, Barbosa Rabago, D, Kerr, DL, Gomez, C, Allegakoen, DV, Guan, J, Shah, KN, Herrington, KA, Gbenedio, OM, Nanjo, S, Majidi, M, Tamaki, W, Pourmoghadam, YK, Rotow, JK, McCoach, CE, Riess, JW, Gutkind, JS, Tang, TT, Post, L, Huang, B, Santisteban, P , Goodarzi, H, Bandyopadhyay, S, Kuo, CJ, Roose, JP, Wu, W, Blakely, CM, Roth, JA, Bivona, TG. Nat Commun - 15 (1) : 3741 (PMID: 38702301) (doi:10.1038/s41467-024-47423-0)
15 Feb | 2023 GLIS3 regulates transcription of thyroid hormone biosynthetic genes in coordination with other thyroid transcription factors. Kang, HS, Grimm, SA, Jothi, R, Santisteban, P , Jetten, AM. Cell Biosci - 13 (1) : 32 (PMID: 36793061) (doi:10.1186/s13578-023-00979-8)
3 Sep | 2022 Inhibiting ERK dimerization ameliorates BRAF-driven anaplastic thyroid cancer. Zaballos, MA , Acuña-Ruiz, A , Morante, M, Riesco-Eizaguirre, G , Crespo, P , Santisteban, P . Cell Mol Life Sci - 79 (9) : 504 (PMID: 36056964) (doi:10.1007/s00018-022-04530-9)
14 Jul | 2022 Basolateral sorting of the sodium iodide symporter NIS is mediated by AP-1 clathrin adaptor complexes. Koumarianou, P , Fernández-Méndez, C , Fajardo-Delgado, D, Mielu, LM, Santisteban, P , de la Vieja, A . Thyroid (PMID: 35833460) (doi:10.1089/thy.2022.0163)
11 May | 2022 Identification of an interactome network between lncRNAs and miRNAs in thyroid cancer reveals SPTY2D1-AS1 as a new tumor suppressor. Ramírez-Moya, J , Wert-Lamas, L , Acuña-Ruíz, A , Fletcher, A , Wert-Carvajal, C , McCabe, CJ, Santisteban, P , Riesco-Eizaguirre, G . Sci Rep - 12 (1) : 7706 (PMID: 35562181) (doi:10.1038/s41598-022-11725-4)
9 Apr | 2022 Genomic and epigenomic profile of thyroid cancer. Acuña-Ruiz, A , Carrasco-López, C , Santisteban, P . Best Pract Res Clin Endocrinol Metab (PMID: 35461756) (doi:10.1016/j.beem.2022.101656)
4 Mar | 2022 Transcriptome profiling of ADAR1 targets in triple-negative breast cancer cells reveals mechanisms for regulating growth and invasion. Baker, AR, Miliotis, C, Ramírez-Moya, J , Marc, T, Vlachos, IS, Santisteban, P , Slack, FJ. Mol Cancer Res (PMID: 35247916) (doi:10.1158/1541-7786.MCR-21-0604)
9 Feb | 2022 Sox9 is involved in the thyroid differentiation program and is regulated by crosstalk between TSH, TGFβ and thyroid transcription factors. López-Márquez, A , Carrasco-López, C , Martínez-Cano, A , Lemoine, P, Pierreux, CE, Santisteban, P . Sci Rep - 12 (1) : 2144 (PMID: 35140269) (doi:10.1038/s41598-022-06004-1)
11 Jan | 2022 Circulating MicroRNA Profiles as Potential Biomarkers for differentiated thyroid cancer recurrence. Jankovic Miljus, J, Guillén-Sacoto, MA, Makiadi-Alvarado, J , Wert-Lamas, L , Ramirez-Moya, J , Robledo, M, Santisteban, P , Riesco-Eizaguirre, G . J Clin Endocrinol Metab (PMID: 35022762) (doi:10.1210/clinem/dgac009)
2 Nov | 2021 A critical balance between Pax8 and the Hippo mediator TAZ determines sodium-iodide symporter NIS expression and function. Fernández-Méndez, C , Santisteban, P . Thyroid (PMID: 34726504) (doi:10.1089/thy.2021.0191)
8 Sep | 2021 An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks. Ramírez-Moya, J , Miliotis, C, Baker, AR, Gregory, RI, Slack, FJ, Santisteban, P . Mol Cancer - 20 (1) : 115 (PMID: 34496885) (doi:10.1186/s12943-021-01401-y)
1 Aug | 2021 The complex regulation of NIS expression and activity in thyroid and extrathyroidal tissues. Riesco-Eizaguirre, G , Santisteban, P , De la Vieja, A . Endocr Relat Cancer (PMID: 34387194) (doi:10.1530/ERC-21-0217)
17 Jul | 2021 BRAF V600E Status Sharply Differentiates Lymph Node Metastasis-associated Mortality Risk in Papillary Thyroid Cancer. Tao, Y, Wang, F, Shen, X, Zhu, G, Liu, R, Viola, D , Elisei, R, Puxeddu, E, Fugazzola, L, Colombo, C, Jarzab, B, Czarniecka, A, Lam, AK, Mian, C, Vianello, F, Yip, L, Riesco-Eizaguirre, G , Santisteban, P , O'Neill, CJ, Sywak, MS, Clifton-Bligh, R, Bendlova, B, Sýkorová, V, Zhao, S, Wang, Y, Xing, M. J Clin Endocrinol Metab (PMID: 34273152) (doi:10.1210/clinem/dgab286)
20 Apr | 2021 Unraveling the Complex Interplay Between Transcription Factors and Signaling Molecules in Thyroid Differentiation and Function, From Embryos to Adults. López-Márquez, A , Carrasco-López, C , Fernández-Méndez, C , Santisteban, P . Front Endocrinol (Lausanne) - 12 : 654569 (PMID: 33959098) (doi:10.3389/fendo.2021.654569)
11 Nov | 2020 A positive feedback loop between DICER1 and differentiation transcription factors is important for thyroid tumorigenesis. Ramírez-Moya, J , Santisteban, P . Thyroid (PMID: 33176626) (doi:10.1089/thy.2020.0297)
10 Sep | 2020 RAS Subcellular Localization Inversely Regulates Thyroid Tumor Growth and Dissemination. García-Ibáñez, Y, Riesco-Eizaguirre, G , Santisteban, P , Casar, B, Crespo, P . Cancers (Basel) - 12 (9) (PMID: 32927904) (doi:10.3390/cancers12092588)
1 Apr | 2020 Gene network transitions in embryos depend upon interactions between a pioneer transcription factor and core histones. Iwafuchi, M, Cuesta, I , Donahue, G, Takenaka, N, Osipovich, AB, Magnuson, MA, Roder, H, Seeholzer, SH, Santisteban, P , Zaret, KS. Nat. Genet. - 52 (4) : 418-427 (PMID: 32203463) (doi:10.1038/s41588-020-0591-8)
26 Mar | 2020 A Novel Role for the Tumor Suppressor Gene ITF2 in Tumorigenesis and Chemotherapy Response. Pernía, O, Sastre-Perona, A , Rodriguez-Antolín, C, García-Guede, A, Palomares-Bralo, M, Rosas, R, Sanchez-Cabrero, D, Cruz, P, Rodriguez, C, Diestro, M, Martín-Arenas, R, Pulido, V, Santisteban, P , Castro, J, Vera, O, Cáceres, II. Cancers (Basel) - 12 (4) (PMID: 32224864) (doi:10.3390/cancers12040786)
10 Mar | 2020 ADAR1-mediated RNA editing is a novel oncogenic process in thyroid cancer and regulates miR-200 activity. Ramírez-Moya, J , Baker, AR, Slack, FJ, Santisteban, P . Oncogene (PMID: 32157211) (doi:10.1038/s41388-020-1248-x)
5 Dec | 2019 Impaired gene expression due to iodine excess in the development and differentiation of endoderm and thyroid is associated with epigenetic changes. Serrano-Nascimento, C , Morillo-Bernal, J , Rosa-Ribeiro, R, Nunes, MT, Santisteban, P . Thyroid (PMID: 31801416) (doi:10.1089/thy.2018.0658)
1 Dec | 2019 FOXE1 regulates migration and invasion in thyroid cancer cells and targets ZEB1. Morillo-Bernal, J , Fernández, LP , Santisteban, P . Endocr. Relat. Cancer (PMID: 31846430) (doi:10.1530/ERC-19-0156)
29 Nov | 2019 BRAF V600E status may facilitate decision-making on active surveillance of low-risk papillary thyroid microcarcinoma. Kim, KJ, Kim, SG, Tan, J, Shen, X, Viola, D , Elisei, R, Puxeddu, E, Fugazzola, L, Colombo, C, Jarzab, B, Czarniecka, A, Lam, AK, Mian, C, Vianello, F, Yip, L, Riesco-Eizaguirre, G , Santisteban, P , O'Neill, CJ, Sywak, MS, Clifton-Bligh, R, Bendlova, B, Sýkorová, V, Xing, M. Eur. J. Cancer - 124 : 161-169 (PMID: 31790974) (doi:10.1016/j.ejca.2019.10.017)
23 Aug | 2019 In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice. Ramirez-Moya, J , Wert-Lamas, L , Acuña-Ruiz, A , Zaballos, MA , Santisteban, P . J Vis Exp (PMID: 31498304) (doi:10.3791/59322)
2 Jul | 2019 miRNA-Directed Regulation of the Main Signaling Pathways in Thyroid Cancer. Ramírez-Moya, J , Santisteban, P . Front Endocrinol (Lausanne) - 10 : 430 (PMID: 31312183) (doi:10.3389/fendo.2019.00430)
1 Jul | 2019 Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness. Ramírez-Moya, J , Wert-Lamas, L , Riesco-Eizaguirre, G , Santisteban, P . Oncogene - 38 (27) : 5486-5499 (PMID: 30967628) (doi:10.1038/s41388-019-0804-8)
1 Jun | 2019 Regulators of the RAS-ERK pathway as therapeutic targets in thyroid cancer. Zaballos, MA , Acuña-Ruiz, A , Morante, M, Crespo, P , Santisteban, P . Endocr. Relat. Cancer - 26 (6) : R319-R344 (PMID: 30978703) (doi:10.1530/ERC-19-0098)
1 May | 2019 Regulation of Foxe1 by Thyrotropin and Transforming Growth Factor Beta Depends on the Interplay Between Thyroid-Specific, CREB and SMAD Transcription Factors. López-Márquez, A , Fernández-Méndez, C , Recacha, P , Santisteban, P . Thyroid - 29 (5) : 714-725 (PMID: 30652527) (doi:10.1089/thy.2018.0136)
19 Sep | 2018 mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. Choe, J, Lin, S, Zhang, W, Liu, Q, Wang, L, Ramirez-Moya, J , Du, P, Kim, W, Tang, S, Sliz, P, Santisteban, P , George, RE, Richards, WG, Wong, KK, Locker, N, Slack, FJ, Gregory, RI. Nature (PMID: 30232453) (doi:10.1038/s41586-018-0538-8)
2 Aug | 2018 BRAF V600E Confers Male Sex Disease-Specific Mortality Risk in Patients With Papillary Thyroid Cancer. Wang, F, Zhao, S, Shen, X, Zhu, G, Liu, R, Viola, D , Elisei, R, Puxeddu, E, Fugazzola, L, Colombo, C, Jarzab, B, Czarniecka, A, Lam, AK, Mian, C, Vianello, F, Yip, L, Riesco-Eizaguirre, G , Santisteban, P , O'Neill, CJ, Sywak, MS, Clifton-Bligh, R, Bendlova, B, Sýkorová, V, Wang, Y, Xing, M. J. Clin. Oncol. (PMID: 30070937) (doi:10.1200/JCO.2018.78.5097)
10 May | 2018 The NFE2-related transcription factor 2 (Nrf2) coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland. Ziros, PG, Habeos, I, Chartoumpekis, DV, Ntalampyra, E, Somm, E, Renaud, CO, Bongiovanni, M, Trougakos, IP, Yamamoto, M, Kensler, TW, Santisteban, P , Carrasco, N, Ris-Stalpers, C, Amendola, E, Liao, XH, Rossich, L, Thomasz, L, Juvenal, GJ, Refetoff, S , Sykiotis, GP. Thyroid (PMID: 29742982) (doi:10.1089/thy.2018.0018)
1 May | 2018 An oncogenic role for microRNA-146b in the thyroid. Ramírez-Moya, J , Santisteban, P . Oncoscience - 5 (5-6) : 155-156 (PMID: 30035174) (doi:10.18632/oncoscience.432)
1 May | 2018 Functional Toll-like Receptor 4 Overexpression in Papillary Thyroid Cancer by MAPK/ERK-Induced ETS1 Transcriptional Activity. Peyret, V, Nazar, M, Martín, M, Quintar, AA, Fernandez, EA, Geysels, RC, Fuziwara, CS, Montesinos, MM, Maldonado, CA, Santisteban, P , Kimura, ET, Pellizas, CG, Nicola, JP, Masini-Repiso, AM. Mol. Cancer Res. - 16 (5) : 833-845 (PMID: 29523762) (doi:10.1158/1541-7786.MCR-17-0433)
1 Apr | 2018 BRAF V600E Mutation-Assisted Risk Stratification of Solitary Intrathyroidal Papillary Thyroid Cancer for Precision Treatment. Huang, Y, Qu, S, Zhu, G, Wang, F, Liu, R, Shen, X, Viola, D , Elisei, R, Puxeddu, E, Fugazzola, L, Colombo, C, Jarzab, B, Czarniecka, A, Lam, AK, Mian, C, Vianello, F, Yip, L, Riesco-Eizaguirre, G , Santisteban, P , O'Neill, CJ, Sywak, MS, Clifton-Bligh, R, Bendlova, B, Sýkorová, V, Xing, M. J. Natl. Cancer Inst. - 110 (4) : 362-370 (PMID: 29165667) (doi:10.1093/jnci/djx227)
1 Apr | 2018 Role of iodide metabolism in physiology and cancer. De la Vieja, A , Santisteban, P . Endocr. Relat. Cancer - 25 (4) : R225-R245 (PMID: 29437784) (doi:10.1530/ERC-17-0515)
1 Mar | 2018 TAZ/WWTR1 Mediates the Pulmonary Effects of NKX2-1 Mutations in Brain-Lung-Thyroid Syndrome. Moya, CM , Zaballos, MA , Garzón, L, Luna, C, Simón, R, Yaffe, MB, Gallego, E, Santisteban, P , Moreno, JC. J. Clin. Endocrinol. Metab. - 103 (3) : 839-852 (PMID: 29294041) (doi:10.1210/jc.2017-01241)
10 Feb | 2018 Patient Age-Associated Mortality Risk Is Differentiated by BRAF V600E Status in Papillary Thyroid Cancer. Shen, X, Zhu, G, Liu, R, Viola, D , Elisei, R, Puxeddu, E, Fugazzola, L, Colombo, C, Jarzab, B, Czarniecka, A, Lam, AK, Mian, C, Vianello, F, Yip, L, Riesco-Eizaguirre, G , Santisteban, P , O'Neill, CJ, Sywak, MS, Clifton-Bligh, R, Bendlova, B, Sýkorová, V, Xing, M. J. Clin. Oncol. - 36 (5) : 438-445 (PMID: 29240540) (doi:10.1200/JCO.2017.74.5497)
22 Jan | 2018 MicroRNA-146b promotes PI3K/AKT pathway hyperactivation and thyroid cancer progression by targeting PTEN. Ramírez-Moya, J , Wert-Lamas, L , Santisteban, P . Oncogene (PMID: 29353884) (doi:10.1038/s41388-017-0088-9)
1 Nov | 2017 Key signaling pathways in thyroid cancer. Zaballos, MA , Santisteban, P . J. Endocrinol. - 235 (2) : R43-R61 (PMID: 28838947) (doi:10.1530/JOE-17-0266)
1 Sep | 2017 The Prognostic Value of Tumor Multifocality in Clinical Outcomes of Papillary Thyroid Cancer. Wang, F, Yu, X, Shen, X, Zhu, G, Huang, Y, Liu, R, Viola, D , Elisei, R, Puxeddu, E, Fugazzola, L, Colombo, C, Jarzab, B, Czarniecka, A, Lam, AK, Mian, C, Vianello, F, Yip, L, Riesco-Eizaguirre, G , Santisteban, P , O'Neill, CJ, Sywak, MS, Clifton-Bligh, R, Bendlova, B, Sýkorová, V, Wang, Y, Liu, S, Zhao, J, Zhao, S, Xing, M. J. Clin. Endocrinol. Metab. - 102 (9) : 3241-3250 (PMID: 28582521) (doi:10.1210/jc.2017-00277)
1 Jan | 2017 Pax8 controls thyroid follicular polarity through cadherin-16. Koumarianou, P , Goméz-López, G, Santisteban, P . J. Cell. Sci. - 130 (1) : 219-231 (PMID: 27780871) (doi:10.1242/jcs.184291)
1 Nov | 2016 ENDOCRINE TUMOURS: Advances in the molecular pathogenesis of thyroid cancer: lessons from the cancer genome. Riesco-Eizaguirre, G , Santisteban, P . Eur. J. Endocrinol. - 175 (5) : R203-17 (PMID: 27666535) (doi:10.1530/EJE-16-0202)
2 Aug | 2016 β-catenin signaling is required for RAS-driven thyroid cancer through PI3K activation. Sastre-Perona, A , Riesco-Eizaguirre, G , Zaballos, MA , Santisteban, P . Oncotarget - 7 (31) : 49435-49449 (PMID: 27384483) (doi:10.18632/oncotarget.10356)
9 Dec | 2015 Selenium increases TSH-induced sodium/iodide symporter expression through Txn/Ape1-dependent regulation of Pax8 binding activity. Leoni, SG , Sastre-Perona, A , De la Vieja, A , Santisteban, P . Antioxid. Redox Signal. (PMID: 26650895) (doi:10.1089/ars.2014.6228)
15 Oct | 2015 Thyroid cancer GWAS identifies 10q26.12 and 6q14.1 as novel susceptibility loci and reveals genetic heterogeneity among populations. Mancikova, V, Cruz, R, Inglada-Pérez, L, Fernández-Rozadilla, C, Landa, I, Cameselle-Teijeiro, J, Celeiro, C, Pastor, S, Velázquez, A, Marcos, R, Andía, V, Álvarez-Escolá, C, Meoro, A, Schiavi, F, Opocher, G, Quintela, I, Ansede-Bermejo, J, Ruiz-Ponte, C, Santisteban, P , Robledo, M, Carracedo, A. Int. J. Cancer - 137 (8) : 1870-1878 (PMID: 25855579) (doi:10.1002/ijc.29557)
1 Oct | 2015 Activation of the GLP-1 Receptor by Liraglutide Increases ACE2 Expression, Reversing Right Ventricle Hypertrophy, and Improving the Production of SP-A and SP-B in the Lungs of Type 1 Diabetes Rats. Romaní-Pérez, M, Outeiriño-Iglesias, V, Moya, CM , Santisteban, P , González-Matías, LC, Vigo, E, Mallo, F. Endocrinology - 156 (10) : 3559-3569 (PMID: 26196539) (doi:10.1210/en.2014-1685)
1 Oct | 2015 The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells during Carcinogenesis. Riesco-Eizaguirre, G , Wert-Lamas, L , Perales-Patón, J, Sastre-Perona, A , Fernández, LP , Santisteban, P . Cancer Res. - 75 (19) : 4119-4130 (PMID: 26282166) (doi:10.1158/0008-5472.CAN-14-3547)
1 Jun | 2015 MicroRNA deep-sequencing reveals master regulators of follicular and papillary thyroid tumors. Mancikova, V, Castelblanco, E, Pineiro-Yanez, E, Perales-Paton, J, de Cubas, AA, Inglada-Perez, L, Matias-Guiu, X, Capel, I, Bella, M, Lerma, E, Riesco-Eizaguirre, G , Santisteban, P , Maravall, F, Mauricio, D, Al-Shahrour, F, Robledo, M. Mod. Pathol. - 28 (6) : 748-757 (PMID: 25720323) (doi:10.1038/modpathol.2015.44)
7 Mar | 2015 DuOx2 Promoter Regulation by Hormones, Transcriptional Factors and the Coactivator TAZ. Cardoso-Weide, LC, Cardoso-Penha, RC, Costa, MW, Ferreira, AC, Carvalho, DP, Santisteban, PS . Eur Thyroid J - 4 (1) : 6-13 (PMID: 25960956) (doi:10.1159/000379749)
1 Jan | 2015 Association between BRAF V600E mutation and recurrence of papillary thyroid cancer. Xing, M, Alzahrani, AS, Carson, KA, Shong, YK, Kim, TY, Viola, D , Elisei, R, Bendlová, B, Yip, L, Mian, C, Vianello, F, Tuttle, RM, Robenshtok, E, Fagin, JA, Puxeddu, E, Fugazzola, L, Czarniecka, A, Jarzab, B, O'Neill, CJ, Sywak, MS, Lam, AK, Riesco-Eizaguirre, G , Santisteban, P , Nakayama, H, Clifton-Bligh, R, Tallini, G, Holt, EH, Sýkorová, V. J. Clin. Oncol. - 33 (1) : 42-50 (PMID: 25332244) (doi:10.1200/JCO.2014.56.8253)
1 Jan | 2015 Thyroid transcription factors in development, differentiation and disease. Fernández, LP , López-Márquez, A , Santisteban, P . Nat Rev Endocrinol - 11 (1) : 29-42 (PMID: 25350068) (doi:10.1038/nrendo.2014.186)
9 Jul | 2014 NIS mediates iodide uptake in the female reproductive tract and is a poor prognostic factor in ovarian cancer. Riesco-Eizaguirre, G , Leoni, SG, Mendiola, M , Estevez-Cebrero, MA, Gallego, MI, Redondo, A, Hardisson, D, Santisteban, P , De la Vieja, A . J. Clin. Endocrinol. Metab. - 99 (7) : E1199-208 (PMID: 24708099) (doi:10.1210/jc.2013-4249)
5 May | 2014 Wnt-independent role of β-catenin in thyroid cell proliferation and differentiation. Sastre-Perona, A , Santisteban, P . Mol. Endocrinol. - 28 (5) : 681-695 (PMID: 24645679) (doi:10.1210/me.2013-1377)
23 Sep | 2013 An epistatic interaction between the PAX8 and STK17B genes in papillary thyroid cancer susceptibility. Landa, I, Boullosa, C, Inglada-Pérez, L, Sastre-Perona, A , Pastor, S, Velázquez, A, Mancikova, V, Ruiz-Llorente, S , Schiavi, F, Marcos, R, Malats, N, Opocher, G, Diaz-Uriarte, R , Santisteban, P , Valencia, A, Robledo, M. PLoS ONE - 8 (9) : e74765 (PMID: 24086368) (doi:10.1371/journal.pone.0074765)
9 Jul | 2013 DNA methylation signatures identify biologically distinct thyroid cancer subtypes. Rodríguez-Rodero, S, Fernández, AF, Fernández-Morera, JL, Castro-Santos, P, Bayon, GF, Ferrero, C, Urdinguio, RG, Gonzalez-Marquez, R, Suarez, C, Fernández-Vega, I, Fresno Forcelledo, MF, Martínez-Camblor, P, Mancikova, V, Castelblanco, E, Perez, M, Marrón, PI, Mendiola, M , Hardisson, D, Santisteban, P , Riesco-Eizaguirre, G , Matías-Guiu, X, Carnero, A, Robledo, M, Delgado-Álvarez, E, Menéndez-Torre, E, Fraga, MF. J. Clin. Endocrinol. Metab. - 98 (7) : 2811-2821 (PMID: 23666970) (doi:10.1210/jc.2012-3566)
13 May | 2013 New insights into FoxE1 functions: identification of direct FoxE1 targets in thyroid cells. Fernández, LP , López-Márquez, A , Martínez, AM, Gómez-López, G, Santisteban, P . PLoS ONE - 8 (5) : e62849 (PMID: 23675434) (doi:10.1371/journal.pone.0062849)
10 Apr | 2013 Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer. Xing, M, Alzahrani, AS, Carson, KA, Viola, D , Elisei, R, Bendlova, B, Yip, L, Mian, C, Vianello, F, Tuttle, RM, Robenshtok, E, Fagin, JA, Puxeddu, E, Fugazzola, L, Czarniecka, A, Jarzab, B, O'Neill, CJ, Sywak, MS, Lam, AK, Riesco-Eizaguirre, G , Santisteban, P , Nakayama, H, Tufano, RP, Pai, SI, Zeiger, MA, Westra, WH, Clark, DP, Clifton-Bligh, R, Sidransky, D, Ladenson, PW, Sykorova, V. JAMA - 309 (14) : 1493-1501 (PMID: 23571588) (doi:10.1001/jama.2013.3190)
1 Jan | 2013 FOXO1 controls thyroid cell proliferation in response to TSH and IGF-I and is involved in thyroid tumorigenesis. Zaballos, MA , Santisteban, P . Mol. Endocrinol. - 27 (1) : 50-62 (PMID: 23160481) (doi:10.1210/me.2012-1032)
24 Apr | 2012 Genome-wide analysis of Pax8 binding provides new insights into thyroid functions. Ruiz-Llorente, S , Carrillo Santa de Pau, E, Sastre-Perona, A , Montero-Conde, C , Gómez-López, G, Fagin, JA, Valencia, A, Pisano, DG, Santisteban, P . BMC Genomics - 13 : 147 (PMID: 22531031) (doi:10.1186/1471-2164-13-147)
1 Mar | 2012 DARPP-32 is required for MAPK/ERK signaling in thyroid cells. Chocarro-Calvo, A , Zaballos, MA , Santisteban, P , García-Jiménez, C. Mol. Endocrinol. - 26 (3) : 471-480 (PMID: 22301787) (doi:10.1210/me.2011-1309)
29 Feb | 2012 Role of the wnt pathway in thyroid cancer. Sastre-Perona, A , Santisteban, P . Front Endocrinol (Lausanne) - 3 : 31 (PMID: 22645520) (doi:10.3389/fendo.2012.00031)
1 Nov | 2011 Regulation of thyroid oxidative state by thioredoxin reductase has a crucial role in thyroid responses to iodide excess. Leoni, SG , Kimura, ET, Santisteban, P , De la Vieja, A . Mol. Endocrinol. - 25 (11) : 1924-1935 (PMID: 21903721) (doi:10.1210/me.2011-0038)
7 Sep | 2011 Telomerase-driven expression of the sodium iodide symporter (NIS) for in vivo radioiodide treatment of cancer: a new broad-spectrum NIS-mediated antitumor approach. Riesco-Eizaguirre, G , De la Vieja, A , Rodríguez, I, Miranda, S , Martín-Duque, P , Vassaux, G, Santisteban, P . J. Clin. Endocrinol. Metab. - 96 (9) : E1435-43 (PMID: 21697253) (doi:10.1210/jc.2010-2373)
1 Mar | 2010 Dynamic expression of Groucho-related genes Grg1 and Grg3 in foregut endoderm and antagonism of differentiation. Santisteban, P , Recacha, P , Metzger, DE, Zaret, KS. Dev. Dyn. - 239 (3) : 980-986 (PMID: 20108349) (doi:10.1002/dvdy.22217)
1 Nov | 2009 The BRAFV600E oncogene induces transforming growth factor beta secretion leading to sodium iodide symporter repression and increased malignancy in thyroid cancer. Riesco-Eizaguirre, G , Rodríguez, I, De la Vieja, A , Costamagna, E , Carrasco, N, Nistal, M, Santisteban, P . Cancer Res. - 69 (21) : 8317-8325 (PMID: 19861538) (doi:10.1158/0008-5472.CAN-09-1248)
4 Sep | 2009 The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. Landa, I, Ruiz-Llorente, S , Montero-Conde, C , Inglada-Pérez, L, Schiavi, F, Leskelä, S, Pita, G, Milne, R, Maravall, J, Ramos, I, Andía, V, Rodríguez-Poyo, P, Jara-Albarrán, A, Meoro, A, del Peso, C, Arribas, L, Iglesias, P, Caballero, J, Serrano, J, Picó, A, Pomares, F, Giménez, G, López-Mondéjar, P, Castello, R, Merante-Boschin, I, Pelizzo, MR, Mauricio, D, Opocher, G, Rodríguez-Antona, C , González-Neira, A, Matías-Guiu, X, Santisteban, P , Robledo, M. PLoS Genet. - 5 (9) : e1000637 (PMID: 19730683) (doi:10.1371/journal.pgen.1000637)
1 Jul | 2008 Thyroid-stimulating hormone/cAMP-mediated proliferation in thyrocytes. García-Jiménez, C, Santisteban, P . Expert Rev Endocrinol Metab - 3 (4) : 473-491 (PMID: 30290436) (doi:10.1586/17446651.3.4.473)
1 May | 2008 Gbetagamma dimers released in response to thyrotropin activate phosphoinositide 3-kinase and regulate gene expression in thyroid cells. Zaballos, MA , Garcia, B, Santisteban, P . Mol. Endocrinol. - 22 (5) : 1183-1199 (PMID: 18202153) (doi:10.1210/me.2007-0093)
1 Mar | 2008 [In Process Citation]. Riesco-Eizaguirre, G , Santisteban, P . Endocrinol Nutr - 55 (3) : 107-110 (PMID: 22967875) (doi:10.1016/S1575-0922(08)70645-4)
1 Dec | 2007 New insights in thyroid follicular cell biology and its impact in thyroid cancer therapy. Riesco-Eizaguirre, G , Santisteban, P . Endocr. Relat. Cancer - 14 (4) : 957-977 (PMID: 18045949) (doi:10.1677/ERC-07-0085)
1 Nov | 2007 Molecular biology of thyroid cancer initiation. Riesco-Eizaguirre, G , Santisteban, P . Clin Transl Oncol - 9 (11) : 686-693 (PMID: 18055323)
2 Oct | 2007 The forkhead factor FoxE1 binds to the thyroperoxidase promoter during thyroid cell differentiation and modifies compacted chromatin structure. Cuesta, I , Zaret, KS, Santisteban, P . Mol. Cell. Biol. - 27 (20) : 7302-7314 (PMID: 17709379) (doi:10.1128/MCB.00758-07)
1 Oct | 2007 Association study of 69 genes in the ret pathway identifies low-penetrance loci in sporadic medullary thyroid carcinoma. Ruiz-Llorente, S , Montero-Conde, C , Milne, RL, Moya, CM , Cebrián, A , Letón, R, Cascón, A, Mercadillo, F, Landa, I, Borrego, S, Pérez de Nanclares, G, Alvarez-Escolá, C, Díaz-Pérez, JA, Carracedo, A, Urioste, M, González-Neira, A, Benítez, J, Santisteban, P , Dopazo, J, Ponder, BA, Robledo, M, , . Cancer Res. - 67 (19) : 9561-9567 (PMID: 17909067) (doi:10.1158/0008-5472.CAN-07-1638)
1 Jul | 2007 TSH signalling and cancer. García-Jiménez, C, Santisteban, P . Arq Bras Endocrinol Metabol - 51 (5) : 654-671 (PMID: 17891229)
1 Oct | 2006 A perspective view of sodium iodide symporter research and its clinical implications. Riesco-Eizaguirre, G , Santisteban, P . Eur. J. Endocrinol. - 155 (4) : 495-512 (PMID: 16990649) (doi:10.1530/eje.1.02257)
24 Jul | 2006 Bacterial lipopolysaccharide stimulates the thyrotropin-dependent thyroglobulin gene expression at the transcriptional level by involving the transcription factors thyroid transcription factor-1 and paired box domain transcription factor 8. Vélez, ML , Costamagna, E , Kimura, ET, Fozzatti, L, Pellizas, CG, Montesinos, MM, Lucero, AM, Coleoni, AH, Santisteban, P , Masini-Repiso, AM. Endocrinology - 147 (7) : 3260-3275 (PMID: 16627577) (doi:10.1210/en.2005-0789)
8 May | 2006 Functional study of a novel single deletion in the TITF1/NKX2.1 homeobox gene that produces congenital hypothyroidism and benign chorea but not pulmonary distress. Moya, CM , Perez de Nanclares, G, Castaño, L, Potau, N, Bilbao, JR, Carrascosa, A, Bargadá, M, Coya, R, Martul, P, Vicens-Calvet, E, Santisteban, P . J. Clin. Endocrinol. Metab. - 91 (5) : 1832-1841 (PMID: 16507635) (doi:10.1210/jc.2005-1497)
1 Mar | 2006 The oncogene BRAF V600E is associated with a high risk of recurrence and less differentiated papillary thyroid carcinoma due to the impairment of Na+/I- targeting to the membrane. Riesco-Eizaguirre, G , Gutiérrez-Martínez, P , García-Cabezas, MA , Nistal, M, Santisteban, P . Endocr. Relat. Cancer - 13 (1) : 257-269 (PMID: 16601293) (doi:10.1677/erc.1.01119)
1 Dec | 2005 DARPP-32 (dopamine and 3',5'-cyclic adenosine monophosphate-regulated neuronal phosphoprotein) is essential for the maintenance of thyroid differentiation. García-Jiménez, C, Zaballos, MA , Santisteban, P . Mol. Endocrinol. - 19 (12) : 3060-3072 (PMID: 16020482) (doi:10.1210/me.2005-0129)
1 Aug | 2005 Thyroid development and effect on the nervous system. Santisteban, P , Bernal, J . Rev Endocr Metab Disord - 6 (3) : 217-228 (PMID: 16151626) (doi:10.1007/s11154-005-3053-9)
6 Aug | 2004 Transcriptional repressor DREAM interacts with thyroid transcription factor-1 and regulates thyroglobulin gene expression. Rivas, M , Mellström, B, Naranjo, JR, Santisteban, P . J. Biol. Chem. - 279 (32) : 33114-33122 (PMID: 15181011) (doi:10.1074/jbc.M403526200)
9 Jul | 2004 Mutation at position -132 in the islet amyloid polypeptide ( IAPP) gene promoter enhances basal transcriptional activity through a new CRE-like binding site. Novials, A, Mato, E, Lucas, M, Franco, C, Rivas, M, Santisteban, P , Gomis, R. Diabetologia - 47 (7) : 1167-1174 (PMID: 15243700) (doi:10.1007/s00125-004-1439-y)
30 Jan | 2004 The functional interaction between the paired domain transcription factor Pax8 and Smad3 is involved in transforming growth factor-beta repression of the sodium/iodide symporter gene. Costamagna, E , García, B , Santisteban, P . J. Biol. Chem. - 279 (5) : 3439-3446 (PMID: 14623893) (doi:10.1074/jbc.M307138200)
15 Jan | 2004 The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors. Vargiu, P , De Abajo, R, Garcia-Ranea, JA, Valencia, A, Santisteban, P , Crespo, P , Bernal, J . Oncogene - 23 (2) : 559-568 (PMID: 14724584) (doi:10.1038/sj.onc.1207161)
31 Dec | 2003 TSH-activated signaling pathways in thyroid tumorigenesis. Rivas, M , Santisteban, P . Mol. Cell. Endocrinol. - 213 (1) : 31-45 (PMID: 15062572) (doi:10.1016/j.mce.2003.10.029)
1 Feb | 2002 PI3K is involved in the IGF-I inhibition of TSH-induced sodium/iodide symporter gene expression. García, B , Santisteban, P . Mol. Endocrinol. - 16 (2) : 342-352 (PMID: 11818505) (doi:10.1210/mend.16.2.0774)
4 Jan | 2002 RhoA activation promotes transformation and loss of thyroid cell differentiation interfering with thyroid transcription factor-1 activity. Medina, DL, Rivas, M , Cruz, P, Barroso, I, Regadera, J, Santisteban, P . Mol. Endocrinol. - 16 (1) : 33-44 (PMID: 11773437) (doi:10.1210/mend.16.1.0749)
24 Aug | 2000 Thyrotropin-dependent proliferation of in vitro rat thyroid cell systems. Medina, DL , Santisteban, P . Eur. J. Endocrinol. - 143 (2) : 161-178 (PMID: 10913934)
15 Jun | 2000 Down-regulation of thyroid transcription factor-1 gene expression in fetal lung hypoplasia is restored by glucocorticoids. Losada, A , Tovar, JA, Xia, HM, Diez-Pardo, JA, Santisteban, P . Endocrinology - 141 (6) : 2166-2173 (PMID: 10830305) (doi:10.1210/endo.141.6.7522)
19 May | 2000 Somatostatin interferes with thyrotropin-induced G1-S transition mediated by cAMP-dependent protein kinase and phosphatidylinositol 3-kinase. Involvement of RhoA and cyclin E x cyclin-dependent kinase 2 complexes. Medina, DL , Toro, MJ, Santisteban, P . J. Biol. Chem. - 275 (20) : 15549-15556 (PMID: 10809788)
1 Apr | 2000 Role of insulin and serum on thyrotropin regulation of thyroid transcription factor-1 and pax-8 genes expression in FRTL-5 thyroid cells. Medina, DL , Suzuki, K, Pietrarelli, M, Okajima, F, Kohn, LD, Santisteban, P . Thyroid - 10 (4) : 295-303 (PMID: 10807057)
13 Jan | 2000 The MDM2 oncoprotein promotes apoptosis in p53-deficient human medullary thyroid carcinoma cells. Dilla, T , Velasco, JA , Medina, DL , González-Palacios, JF, Santisteban, P . Endocrinology - 141 (1) : 420-429 (PMID: 10614665) (doi:10.1210/endo.141.1.7265)
1 Jan | 2000 The MDM2 Oncoprotein Promotes Apoptosis in p53-Deficient Human Medullary Thyroid Carcinoma Cells1. Dilla, T, Velasco, JA, Medina, DL, Gonza Lez-Palacios, JF, Santisteban, P . Endocrinology - 141 (1) : 420-429 (PMID: 28200932) (doi:10.1210/endo.141.1.7265)
9 Sep | 1999 Hexachlorobenzene, a dioxin-type compound, increases malic enzyme gene transcription through a mechanism involving the thyroid hormone response element. Loaiza-Pérez, AI, Seisdedos, MT , Kleiman de Pisarev, DL, Sancovich, HA, Randi, AS, Ferramola de Sancovich, AM, Santisteban, P . Endocrinology - 140 (9) : 4142-4151 (PMID: 10465287) (doi:10.1210/endo.140.9.6996)
1 Sep | 1999 Hexachlorobenzene, a Dioxin-Type Compound, Increases Malic Enzyme Gene Transcription through a Mechanism Involving the Thyroid Hormone Response Element1. Loaiza-Pe Rez, AI, Seisdedos, MT, Kleiman de Pisarev, DL, Sancovich, HA, Randi, AS, Ferramola de Sancovich, AM, Santisteban, P . Endocrinology - 140 (9) : 4142-4151 (PMID: 28201019) (doi:10.1210/endo.140.9.6996)
1 Aug | 1999 Norepinephrine, tri-iodothyronine and insulin upregulate glyceraldehyde-3-phosphate dehydrogenase mRNA during Brown adipocyte differentiation. Barroso, I , Benito, B, Garcí-Jiménez, C, Hernández, A, Obregón, MJ , Santisteban, P . Eur. J. Endocrinol. - 141 (2) : 169-179 (PMID: 10427161)
15 Jul | 1999 Lung hypoplasia caused by nitrofen is mediated by down-regulation of thyroid transcription factor TTF-1. Losada, A , Xia, H, Migliazza, L, Diez-Pardo, JA, Santisteban, P , Tovar, JA. Pediatr. Surg. Int. - 15 (3-4) : 188-191 (PMID: 10370019)
18 Jun | 1999 Insulin-induced early growth response gene (Egr-1) mediates a short term repression of rat malic enzyme gene transcription. Barroso, I , Santisteban, P . J. Biol. Chem. - 274 (25) : 17997-18004 (PMID: 10364249)
21 May | 1999 The interaction between the forkhead thyroid transcription factor TTF-2 and the constitutive factor CTF/NF-1 is required for efficient hormonal regulation of the thyroperoxidase gene transcription. Ortiz, L , Aza-Blanc, P, Zannini, M, Cato, AC, Santisteban, P . J. Biol. Chem. - 274 (21) : 15213-15221 (PMID: 10329730)
1 Apr | 1999 Thyroid-specific gene expression in the multi-step process of thyroid carcinogenesis. Ros, P, Rossi, DL, Acebrón, A, Santisteban, P . Biochimie - 81 (4) : 389-396 (PMID: 10401674)
28 Jan | 1999 Somatostatin is expressed in FRTL-5 thyroid cells and prevents thyrotropin-mediated down-regulation of the cyclin-dependent kinase inhibitor p27kip1. Medina, DL , Velasco, JA , Santisteban, P . Endocrinology - 140 (1) : 87-95 (PMID: 9886811) (doi:10.1210/endo.140.1.6426)
24 Jun | 1998 Ha-ras interference with thyroid cell differentiation is associated with a down-regulation of thyroid transcription factor-1 phosphorylation. Velasco, JA , Acebrón, A, Zannini, M, Martín-Pérez, J , Di Lauro, R, Santisteban, P . Endocrinology - 139 (6) : 2796-2802 (PMID: 9607786) (doi:10.1210/endo.139.6.6076)
5 Jun | 1998 Ontogeny and cellular localization of the pyruvate recycling system in rat brain. Cruz, F , Scott, SR, Barroso, I , Santisteban, P , Cerdán, S . J. Neurochem. - 70 (6) : 2613-2619 (PMID: 9603228)
4 Nov | 1997 Introduction of p53 induces cell-cycle arrest in p53-deficient human medullary-thyroid-carcinoma cells. Velasco, JA , Medina, DL , Romero, J, Mato, ME, Santisteban, P . Int. J. Cancer - 73 (3) : 449-455 (PMID: 9359494)
1 Nov | 1997 Circannual somatostatin gene and somatostatin receptor gene expression in the early post-natal rat pineal gland. Mato, E, Santisteban, P , Chowen, JA, Fornas, O, Bouwens, M, Puig-Domingo, M, Argente, J, Webb, SM. Neuroendocrinology - 66 (5) : 368-374 (PMID: 9387856)
12 Sep | 1997 Transcriptional control of the forkhead thyroid transcription factor TTF-2 by thyrotropin, insulin, and insulin-like growth factor I. Ortiz, L , Zannini, M, Di Lauro, R, Santisteban, P . J. Biol. Chem. - 272 (37) : 23334-23339 (PMID: 9287345)
10 Jan | 1997 Identification and quantitation of iodotyrosines and iodothyronines in proteins using high-performance liquid chromatography by photodiode-array ultraviolet-visible detection. de la Vieja, A , Calero, M, Santisteban, P , Lamas, L. J. Chromatogr. B Biomed. Sci. Appl. - 688 (1) : 143-149 (PMID: 9029324)
1 Sep | 1996 Amino Acid Composition of Proteins Extracted from Endemic Goiter Glands. Baggio, MC, Medeiros-Neto, G, Osawa, Y, Nguyen, NY, Santisteban, P , Knobel, M, Groliman, EE. Endocr. Pathol. - 7 (2) : 137-143 (PMID: 12114641)
26 Jan | 1996 Mapping and functional role of phosphorylation sites in the thyroid transcription factor-1 (TTF-1). Zannini, M, Acebron, A, De Felice, M, Arnone, MI, Martin-Pérez, J , Santisteban, P , Di Lauro, R. J. Biol. Chem. - 271 (4) : 2249-2254 (PMID: 8567686)
29 Sep | 1995 Function of the homeo and paired domain proteins TTF-1 and Pax-8 in thyroid cell proliferation. Rossi, DL, Acebrón, A, Santisteban, P . J. Biol. Chem. - 270 (39) : 23139-23142 (PMID: 7559458)
1 Aug | 1995 Congenital human thyroglobulin defect due to low expression of the thyroid-specific transcription factor TTF-1. Acebrón, A, Aza-Blanc, P, Rossi, DL, Lamas, L, Santisteban, P . J. Clin. Invest. - 96 (2) : 781-785 (PMID: 7635972) (doi:10.1172/JCI118123)
1 Jul | 1995 Comparative effects of food restriction, fasting, diabetes and thyroidectomy on growth hormone and thyrotropin gene expression in the rat pituitary. Rodríguez, M , Rodríguez, F, Jolin, T, Santisteban, P . Eur. J. Endocrinol. - 133 (1) : 110-116 (PMID: 7627331)
1 Oct | 1994 Insulin regulation of malic enzyme gene expression in rat liver: evidence for nuclear proteins that bind to two putative insulin response elements. García-Jiménez, C, Benito, B, Jolin, T, Santisteban, P . Mol. Endocrinol. - 8 (10) : 1361-1369 (PMID: 7854353) (doi:10.1210/mend.8.10.7854353)
1 Oct | 1993 Identification of a cis-regulatory element and a thyroid-specific nuclear factor mediating the hormonal regulation of rat thyroid peroxidase promoter activity. Aza-Blanc, P, Di Lauro, R, Santisteban, P . Mol. Endocrinol. - 7 (10) : 1297-1306 (PMID: 8264661) (doi:10.1210/mend.7.10.8264661)
1 Aug | 1993 Expression of somatostatin in rat pineal cells in culture. Mato, E, Santisteban, P , Viader, M, Capellá, G, Fornas, O, Puig-Domingo, M, Webb, SM. J. Pineal Res. - 15 (1) : 43-45 (PMID: 7901362)
15 Jul | 1993 Regulation of malic-enzyme-gene expression by cAMP and retinoic acid in differentiating brown adipocytes. Hernandez, A, Garcia-Jimenez, C , Santisteban, P , Obregon, MJ . Eur. J. Biochem. - 215 (2) : 285-290 (PMID: 8393790)
30 Apr | 1993 Malic enzyme gene expression in differentiating brown adipocytes: regulation by insulin and triiodothyronine. García-Jimenez, C , Hernández, A, Obregón, MJ , Santisteban, P . Endocrinology - 132 (4) : 1537-1543 (PMID: 8462451) (doi:10.1210/endo.132.4.8462451)
1 Aug | 1992 Insulin and insulin-like growth factor I regulate a thyroid-specific nuclear protein that binds to the thyroglobulin promoter. Santisteban, P , Acebrón, A, Polycarpou-Schwarz, M, Di Lauro, R. Mol. Endocrinol. - 6 (8) : 1310-1317 (PMID: 1406708) (doi:10.1210/mend.6.8.1406708)
27 Jul | 1992 Expression of thyroglobulin gene in maternal and fetal thyroid in rats. Rodríguez, M , Santisteban, P , Acebrón, A, Hernandez, LC, del Valle, M, Jolin, T. Endocrinology - 131 (1) : 415-422 (PMID: 1612022) (doi:10.1210/endo.131.1.1612022)
1 Nov | 1991 Expression of the growth hormone gene and the pituitary-specific transcription factor GHF-1 in diabetic rats. Bedo, G, Santisteban, P , Jolin, T, Aranda, A . Mol. Endocrinol. - 5 (11) : 1730-1739 (PMID: 1779974) (doi:10.1210/mend-5-11-1730)
30 Aug | 1990 Familial goiter in bongo antelope (Tragelaphus eurycerus). Doi, S, Shifrin, S, Santisteban, P , Montali, RJ, Schiller, C, Bush, M, Grollman, EF. Endocrinology - 127 (2) : 857-864 (PMID: 2373058) (doi:10.1210/endo-127-2-857)
1 Sep | 1989 Sequence and chromosomal assignment of a novel cDNA identified by immunoscreening of a thyroid expression library: similarity to a family of mitochondrial solute carrier proteins. Zarrilli, R, Oates, EL, McBride, OW, Lerman, MI, Chan, JY, Santisteban, P , Ursini, MV, Notkins, AL, Kohn, LD. Mol. Endocrinol. - 3 (9) : 1498-1505 (PMID: 2575220) (doi:10.1210/mend-3-9-1498)
1 Jun | 1989 Subcellular localization of iodinated thyroid tubulin. Hargreaves, AJ, Lamas, L, Santisteban, P , Avila, J. Biosci. Rep. - 9 (3) : 375-382 (PMID: 2775864)
18 May | 1989 Retinoic acid regulates growth hormone gene expression. Bedo, G, Santisteban, P , Aranda, A . Nature - 339 (6221) : 231-234 (PMID: 2716850) (doi:10.1038/339231a0)
5 Mar | 1989 Cloning and characterization of a cDNA that encodes a 70-kDa novel human thyroid autoantigen. Chan, JY, Lerman, MI, Prabhakar, BS, Isozaki, O, Santisteban, P , Kuppers, RC, Oates, EL, Notkins, AL, Kohn, LD. J. Biol. Chem. - 264 (7) : 3651-3654 (PMID: 2917966)
21 Sep | 1987 Insulin and insulin-like growth factor-I (IGF-I) regulate differentiation as well as growth in FRTL-5 cells. Isozaki, O, Santisteban, P , Chan, J, Grollman, E, Kohn, L. Acta Endocrinol Suppl (Copenh) - 281 : 288-292 (PMID: 3303791)
21 Sep | 1987 TSH and biogenic amine signals in the regulation of thyroid function: independent regulation by protein kinase C and G proteins. Grollman, EF, Bone, E, Chan, J, Corda, D, Isozaki, O, Marcocci, C, Santisteban, P , Kohn, LD. Acta Endocrinol Suppl (Copenh) - 281 : 199-202 (PMID: 3113150)
21 Sep | 1987 TSH receptor structure. Chan, J, Santisteban, P , De Luca, M, Isozaki, O, Grollman, E, Kohn, L. Acta Endocrinol Suppl (Copenh) - 281 : 166-172 (PMID: 3475898)
25 Jul | 1987 Characterization of phosphate residues on thyroglobulin. Consiglio, E, Acquaviva, AM, Formisano, S, Liguoro, D, Gallo, A, Vittorio, T, Santisteban, P , De Luca, M, Shifrin, S, Yeh, HJ. J. Biol. Chem. - 262 (21) : 10304-10314 (PMID: 2440862)
26 Mar | 1987 Norepinephrine and thyrotropin stimulation of iodide efflux in FRTL-5 thyroid cells involves metabolites of arachidonic acid and is associated with the iodination of thyroglobulin. Marcocci, C, Luini, A, Santisteban, P , Grollman, EF. Endocrinology - 120 (3) : 1127-1133 (PMID: 3100285) (doi:10.1210/endo-120-3-1127)
25 Mar | 1987 Thyroglobulin gene expression is regulated by insulin and insulin-like growth factor I, as well as thyrotropin, in FRTL-5 thyroid cells. Santisteban, P , Kohn, LD, Di Lauro, R. J. Biol. Chem. - 262 (9) : 4048-4052 (PMID: 3549723)
23 Dec | 1986 Monoclonal antibody studies defining the origin and properties of autoantibodies in Graves' disease. Kohn, LD, Alvarez, F, Marcocci, C, Kohn, AD, Corda, D, Hoffman, WE, Tombaccini, D, Valente, WA, de Luca, M, Santisteban, P . Ann. N. Y. Acad. Sci. - 475 : 157-173 (PMID: 3491561)
25 Jun | 1986 Iodine suppression of iodide uptake in FRTL-5 thyroid cells. Grollman, EF, Smolar, A, Ommaya, A, Tombaccini, D, Santisteban, P . Endocrinology - 118 (6) : 2477-2482 (PMID: 3009160) (doi:10.1210/endo-118-6-2477)
1 May | 1986 Evidence, by in vitro enzymatic iodination of thyroglobulin, that the efficiency of coupling is determined by the initial iodide concentration. Lamas, L, Santisteban, P , Turmo, C, Seguido, AM . Endocrinology - 118 (5) : 2131-2136 (PMID: 3698909) (doi:10.1210/endo-118-5-2131)
29 Aug | 1985 Effects of high doses of iodide on thyroid secretion: evidence for the presence of iodinated membrane tubulin. Santisteban, P , Hargreaves, AJ, Cano, J, Avila, J, Lamas, L. Endocrinology - 117 (2) : 607-612 (PMID: 4017949) (doi:10.1210/endo-117-2-607)
1 Aug | 1984 Cerebral hypothyroidism in rats with adult-onset iodine deficiency. Obregón, MJ , Santisteban, P , Rodríguez-Peña, A , Pascual, A , Cartagena, P, Ruiz-Marcos, A, Lamas, L, Escobar del Rey, F , Morreale de Escobar, G . Endocrinology - 115 (2) : 614-624 (PMID: 6745172) (doi:10.1210/endo-115-2-614)
1 May | 1982 Are iodine-deficient rats euthyroid? Santisteban, P , Obregon, MJ , Rodriguez-Peña, A , Lamas, L, Del Rey, FE, De Escobar, GM. Endocrinology - 110 (5) : 1780-1789 (PMID: 6804212) (doi:10.1210/endo-110-5-1780)
1 May | 1982 Involution of rat iodoprive hyperplastic goiter: effect of iodide administration on thyroid function and lysosomal properties. van den Hove-Vandenbroucke, MF, Santisteban, P , Couvreur, M, Obregon, MJ , Lamas, L. Endocrinology - 110 (5) : 1812-1818 (PMID: 6176441) (doi:10.1210/endo-110-5-1812)
1 Dec | 1981 The effect of varying iodine content on the proteolytic activity of rat thyroid lysosomes. Santisteban, P , Lamas, L. Acta Endocrinol. - 98 (4) : 556-563 (PMID: 6272517)
27 Feb | 1980 Re-evaluation of some factors affecting the stability of rat thyroglobulin. Lamas, L, Santisteban, P . Biochim. Biophys. Acta - 621 (2) : 265-272 (PMID: 7353044)